Astral Codex Ten

Deplin

3 min read

Deplin

Article

Deplin is a recurring brand in the Astral Codex Ten archive, appearing 2 times across 2 issues between May 12, 2021 and May 25, 2021. The archive places it in contexts such as “Nor is there much difference between regular methylfolate and prescription Deplin”; “The FDA-approved version is called Deplin , and is prescription-only and more expensive”. It most often appears alongside FDA, US, 2002 meta-analysis by Cochrane Collaboration.

Metadata

  • Category: Brands
  • Mention count: 2
  • Issue count: 2
  • First seen: May 12, 2021
  • Last seen: May 25, 2021

Appears In

Source Context

Recovered passages from the original issue text. When the raw archive preserved outbound links inside the source passage, they are listed directly under the quote.

Welcome To The Terrible World Of Prescription-Only Apps
May 12, 2021 · Original source
Maybe you’ve read my old post on Lovaza? Lovaza is prescription fish oil. You can get non-prescription fish oil from any supermarket or supplement store for $10 per Giant Jar. Or, if you prefer, you can go to a doctor and get prescribed Lovaza for $300 a month. Is there a difference between Lovaza and regular fish oil? Other than the 30x markup and prescription-gating, no. Nor is there much difference between regular methylfolate and prescription Deplin. You can get some effective treatment for very cheap as a supplement. Or you can get the same treatment for much more money as a prescription medication.
Inline links: my old post on Lovaza
Peer Review Request: Depression
May 25, 2021 · Original source
L-methylfolate is a form of folic acid, aka Vitamin B9, common in various vegetables. It’s part of various important chemical processes in the body, including the synthesis of serotonin, and various studies support its use in depression. Some people will try to claim that a gene called MTHFR is very relevant here, but I disagree with this and will have a page up about it eventually – the summary is that you should consider using l-methylfolate regardless of what allele of MTHFR you have. I’ve listed this supplement first because it’s the only one which has been officially approved by the FDA as safe and effective for depression. The FDA-approved version is called Deplin, and is prescription-only and more expensive, but it’s chemically identical to regular l-methylfolate which you can buy without a prescription in stores. Be careful as many stores will sell 1 mg tablets, but the recommended dose is 7.5 – 15 mg daily. You can get l-methylfolate 15 mg here.
Inline links: various studies, Deplin, here