Astral Codex Ten

paroxetine

4 min read

paroxetine

Article

paroxetine is a recurring brand in the Astral Codex Ten archive, appearing 3 times across 3 issues between March 31, 2021 and February 29, 2024. The archive places it in contexts such as “16.7 mg Lexapro equals 20 mg of paroxetine (Paxil)”; “It did significantly better than paroxetine”; “SSRI called paroxetine (Paxil)“. It most often appears alongside SSRIs, FDA, @BoyanSlat.

Metadata

  • Category: Brands
  • Mention count: 3
  • Issue count: 3
  • First seen: March 31, 2021
  • Last seen: February 29, 2024

Appears In

Source Context

Recovered passages from the original issue text. When the raw archive preserved outbound links inside the source passage, they are listed directly under the quote.

Oh, The Places You'll Go When Trying To Figure Out The Right Dose Of Escitalopram
March 31, 2021 · Original source
16.7 mg Lexapro equals 20 mg of paroxetine (Paxil) or fluoxetine (Prozac). But the maximum approved doses of those medications are 60 mg and 80 mg, respectively. If we convert these to mg imipramine equivalents like the study above uses, Prozac maxes out at 400, Paxil at 300, and Lexapro at 120. So Lexapro has a very low maximum dose compared to other similar antidepressants. Why?
Prozac: 30 mg Paxil: 30 mg Zoloft: 75 mg Celexa: 30 mg Lexapro: 15 mg
Lavender's Game: Silexan For Anxiety
May 18, 2022 · Original source
So fine, let’s look at the studies. A typical example is Kaspar (2014), Lavender oil preparation Silexan is effective in generalized anxiety disorder. It has 539 people, which is really quite impressive - usually these kinds of supplement trials would have more like 10% of that. The study is double-blind (patients don’t know if they’re getting silexan or placebo, and doctors don’t know which one they’re giving) and they made sure the placebo capsules smelled like lavender (a nice touch!) The groups were randomized carefully, but there were some statistically significant random differences between them; none of them seemed too worrying to me but your opinion might differ. There was a clear, obvious, and dose-dependent effect of silexan vs. placebo (p < 0.001) on seven of eight outcomes measured; the eighth was “physical health” and it’s fine if an anxiety drug doesn’t help with this (although you could always hope it would relieve some ailments by making people less stressed). It did significantly better than paroxetine, which only reached statistically significant effect size on about half of the outcomes (par for the course in these kinds of studies, SSRIs are kind of weak). Effect size was 0.37 for the 80 mg dose, and 0.5 for the 160 mg dose.
Inline links: Lavender oil preparation Silexan is effective in generalized anxiety disorder
Links For February 2024
February 29, 2024 · Original source
SSRIs usually are an option during pregnancy . . . risks include high blood pressure for the pregnant person and premature birth. These risks are small. Your health care team watches for them during your prenatal care. Most studies show that SSRIs aren't linked with birth defects. But an SSRI called paroxetine (Paxil) might slightly raise the risk of heart defects in babies when used during the first trimester.