Astral Codex Ten

Lantern

6 min read

Lantern

Article

Lantern is a recurring organization in the Astral Codex Ten archive, appearing 2 times across 2 issues between December 07, 2023 and April 16, 2024. The archive places it in contexts such as “Lantern says the levels of mutacin-1140 dilute to irrelevance”; “Lantern offers a $100 bounty to anyone who can come up with one they haven’t thought of yet”; “Lantern spent $400,000 acquiring rights and synthesizing the organism”. It most often appears alongside Aaron, BCS3-L1, Dr. Hillman.

Metadata

  • Category: Organizations
  • Mention count: 2
  • Issue count: 2
  • First seen: December 07, 2023
  • Last seen: April 16, 2024

Appears In

Source Context

Recovered passages from the original issue text. When the raw archive preserved outbound links inside the source passage, they are listed directly under the quote.

Defying Cavity: Lantern Bioworks FAQ
December 07, 2023 · Original source
Lantern Bioworks says they have a cure for tooth decay. Their product is a genetically modified bacterium which infects your mouth, outcompetes all the tooth-decay-causing bacteria, and doesn’t cause tooth decay itself. If it works, it could make cavities a thing of the past (you should still brush for backup and cosmetic reasons).
Inline links: Lantern Bioworks, a cure for tooth decay
I talked to Lantern founder Aaron Silverbook to get an idea of how this works, both in a biological and an economic sense. Aaron was very knowledgeable and forthcoming, although he uses the phrase “YOLO” somewhat more often than most biotech founders. This post isn’t a verbatim interview transcript, just a writeup of what I learned based on his answers.
[Conflict of interest notice: Lantern is mostly rationalists and includes some friends. My wife consulted for them early on. They offered my wife and me free samples (based on her work, not as compensation for writing this post); she accepted, and I’m still debating. Consider this an attempt to spotlight interesting work that people I like are doing, not a hard-hitting investigation.]
Updates on Lumina Probiotic
April 16, 2024 · Original source
Lumina, the genetically modified anti-tooth-decay bacterium that I wrote about in December, is back in the news after lowering its price from $20,000 to $250 and getting endorsements from Yishan Wong, Cremieux, and Richard Hanania (as well as anti-endorsements from Saloni and Stuart Ritchie). A few points that have come up:
Inline links: I wrote about in December, $250, Yishan Wong, Cremieux, Richard Hanania, Saloni, Stuart Ritchie
Commenters (and Kevin Drum) searched publicly-available archives and found a slightly different story, with three trials:
Inline links: Commenters, and Kevin Drum
The rats with the new strain (BCS3-L1) got only 1/3 the normal rats’ “caries score”. But they didn’t get a score of zero. So maybe claims like “BCS3 represents a complete cure for cavities” are overblown. Why didn’t rats with the new strain get zero dental caries? Bacteria other than S. mutans can also cause cavities, so maybe it’s one of those. Rat trials are famous for results that don’t replicate in human trials, so take these with a grain of salt. 3: What did the latest colonization studies show? Aaron was able to retest six people who got free samples in December. Four of those people still have the bacterium. The other two don’t. Of the two failures, one had an active cavity at the time the strain was applied (which interferes with the oral microbiome), and the other had his wisdom teeth removed (which involves rinsing the mouth with strong antiseptics). Aaron hopes this shows the strain will stick around in most normal situations (though the failure in the presence of active cavities is disappointing). 4: Any new concerns about side effects? In my original post, I mentioned the possibility that this would set off Breathalyzers. Lantern was able to test this, and proved that it wasn’t a problem. Yesterday, Lao Mein suggested on Less Wrong that it might raise oral cancer risk - their post focused on people with ALDH deficiency (most common in Asians) but the calculations are too vague to be sure exactly which groups should and shouldn’t worry. This is less than 24 hours old, the company hasn’t replied yet, and is still developing. I’ll try to update people if anyone gets more clarity on this. Someone on the post mentioned that they’ve gotten worse hangovers since using the product, maybe because the constant trickle of alcohol changed the way gut flora metabolize it. 5: Any other meaningful results since the samples? Cremieux says his breath smells better. Some people have objected to this claim on the grounds that it takes ~12 months before the bacterium has colonized your mouth. One of the figures in my earlier post suggested that the bacterium might start strong, retreat for a while, and then take 12 months to fully colonize, so that might potentially explain his findings. But also, is it biologically plausible that this prevents bad breath? My impression was that bad breath came from other bacterial byproducts besides lactic acid. It might be possible in theory that the same metabolic changes that switch lactic acid to alcohol disrupt these other byproducts, but it seems kind of unlikely. An alternate explanation is that, in order to apply this product at all, you need to do a dentist-style teeth cleaning that kills your previous mouth bacteria. Maybe that improves the bad breath regardless of whether you add the Lumina afterwards? Some other people have said their mouth feels fresher or something, but realistically all of this is overwhelmingly likely to be placebo. 6: Do I “endorse” Lumina? Richard Hanania has a post about how he trusts Lumina because I’ve endorsed them. It’s extremely kind and I appreciate his respect. But also, the most I said in the original post was that I was still debating whether or not to get the treatment. My real opinion, as precisely as I can express it, is: Advance of approximately the same magnitude as fluoride: 5%
Inline links: Bacteria other than, Lao Mein suggested on Less Wrong that it might raise oral cancer risk, says his breath smells better, has a post about how he trusts Lumina because I’ve endorsed them