Musk

Article

Musk is a recurring person in the Astral Codex Ten archive, appearing 23 times across 23 issues between March 25, 2021 and December 10, 2025. The archive places it in contexts such as “Tesla did something like this when Musk though the big dogs were neglecting electric”; “I think of people like Napoleon, Musk and yes, even Kanye”; “Musk comes in and fires me just like that”. It most often appears alongside Elon Musk, Twitter, OpenAI.

Metadata

Category: People
Mention count: 23
Issue count: 23
First seen: March 25, 2021
Last seen: December 10, 2025

Appears In

- Elon Musk (13 shared issues)
- Twitter (10 shared issues)
- OpenAI (8 shared issues)
- Metaculus (7 shared issues)
- California (6 shared issues)
- China (6 shared issues)
- Elon (6 shared issues)
- Trump (6 shared issues)
- Anthropic (5 shared issues)
- Biden (5 shared issues)
- Manifold (5 shared issues)
- Sam Altman (5 shared issues)

External Links

Source Context

Recovered passages from the original issue text. When the raw archive preserved outbound links inside the source passage, they are listed directly under the quote.

More Antifragile, Diversity Libertarianism, And Corporate Censorship

March 25, 2021 · Original source

When might this not work? First, if cars are hard, and starting a new car company takes too much time. I'm not too concerned about this one. I think a lot of people could potentially make one or two crappy 1920s-style cars in their garage with a little work, and once they do that, black people with no other options will buy them, and that will give them enough money to bootstrap into a powerful car company that can compete with the big dogs. Tesla did something like this when Musk though the big dogs were neglecting electric, and that went great.

Highlights From The Comments On "Sadly, Porn"

April 20, 2022 · Original source

As I see it, there's two ways out of this: the humorous, easy-going, dropping-all-pretense, relatively carefree attitude of some "enlightened ones" (mystics, daoist sages, zen masters), who seem to have found a sort of joyful nihilism in their appraisal of reality, or the titanism of individuals who manage to manifest their desires and their will-to-power in the world (I think of people like Napoleon, Musk and yes, even Kanye). Maybe their power and charisma, like your friend's aptitude to be a cult leader, comes from their ability to own and manifest actual desires, achieve individuation, and become a true personality, while their followers get to at least experience it vicariously and partially appropriate their personality through identification, like children who play at being adults.

But then again, can you tell if enlightenment is "the real deal" and not just another pretense? Is Musk manifesting his individuality, or is he running away like everyone else? It doesn't matter: it doesn't concern _you_, so asking these questions is just another distraction.

Every Bay Area House Party

May 04, 2022 · Original source

“I shouldn’t tell, but . . . oh, whatever, I’m pretty drunk right now. What you do is - you come up with your ideal guest list - who would you invite if you knew they were going to say yes. Actors, billionaires, all the coolest people in your social circle. Then you send them all an email saying - hey, Elon Musk is going to be at this party, you want to come? Of course they all say yes. Then, a few days before the party, you send out an email - sorry, Elon has to cancel, but we’ve still got [list of actors, billionaires, and all the coolest people in your social circle]. Everyone agrees that’s still a pretty amazing guest list and decides to come anyway. Win win. It’s like that quote about how God is so powerful that He doesn’t even need to exist in order to save us.”

“Okay, but surely you can do this only once per group of people. If some cool actress gets five invitations to parties with Elon Musk a week, and he never shows up to any of them, eventually she’s going to catch on.”

“Lies about Elon Musk coming to your party as a service. Capitalism really is great.”

Which Party Has Gotten More Extreme Faster?

June 08, 2022 · Original source

Matt Yglesias has written a couple of posts (1, 2) on the subject of this meme (originally by Colin Wright, recently signal-boosted by Elon Musk):

Inline links: 1, 2

The above in Wright/Musk meme format. Obviously in real life conservatives aren’t this consistent, and move left too - just at a slower rate than the liberals. So on a first principles argument, it seems kind of obvious that by this definition Democrats will “get more extreme” over time in a way Republicans don’t.

When you average all of these out, Democrats have gotten 22 points more likely to support the liberal side of an issue, and Republicans have gotten 0 points more likely to support the conservative (technically 0.1, but the graphs don’t have enough significant figures to make that meaningful). This corresponds pretty exactly to the Wright/Musk meme where the conservatives stay in the same place as the liberals get more and more extreme.

June 13, 2022 · Original source

$2000 in liquidity and still 14% off from Metaculus, weird. Musk Vs. Marcus Elon Musk recently said he thought we might have AGI before 2029, and Gary Marcus said we wouldn’t and offered to bet on it. It’s an important tradition of AGI discussions that nobody can ever agree on a definition of it and it has to be re-invented every time the topic comes up. Marcus proposed five different things he thought an AI couldn’t do before 2029, such that if it does them, he admits he was wrong and Musk wins the bet (which purely hypothetical at this point; Musk hasn’t responded). The AI would have to do at least three of: Read a novel and answer complicated questions about eg the themes (existing language models can do this with pre-digested novels, eg LAMDA talking about Les Miserables here - I think Marcus means you have to give it a new novel that it has no corpus of humans ever having discussed before, and make it do the work itself).

Inline links: said we wouldn’t, here

1: Wild ride, huh? It would be a fun troll to do whatever you have to in order to keep this market at exactly 50%. For all I know maybe that’s what Musk is doing.

Inline links: https://www.metaculus.com/questions/10662/will-elon-musk-buy-twitter-in-2022/

Wild ride, huh? It would be a fun troll to do whatever you have to in order to keep this market at exactly 50%. For all I know maybe that’s what Musk is doing.

Billionaires, Surplus, And Replaceability

August 31, 2022 · Original source

I don’t know what a fair economic system that takes this model into account would look like. It wouldn’t look like “billionaires shouldn’t exist”, because it might be that pushing Amazon forward by two years is indeed worth several billion dollars. It wouldn’t even look like “higher taxes on all billionaires in the hopes of having them have less money and maybe that will bring them closer to the fair level”, because plausibly some billionaires aren’t replaceable - I’m not sure anyone else would have started SpaceX if Musk hadn’t. But this model convinces me that “taxing billionaires a lot” and “taxing billionaires not at all” are at least two different unfair failure modes with their own advantages and disadvantages from a desert point of view.

Semaglutidonomics

November 24, 2022 · Original source

“Wegovy” sounds like either a cooperative governance platform, or some kind of obscure medieval sin. Weight loss pills have a bad reputation. But Wegovy is a big step up. It doesn’t work for everybody. But it works for 66-84% of people, depending on your threshold. (Source) Of six major weight loss drugs, only two - Wegovy and Qsymia - have a better than 50-50 chance of helping you lose 10% of your weight. Qsymia works partly by making food taste terrible; it can also cause cognitive issues. Wegovy feels more natural; patients just feel full and satisfied after they’ve eaten a healthy amount of food. You can read the gushing anecdotes here (plus some extra anecdotes in the comments). Wegovy patients also lose more weight on average than Qsymia patients - 15% compared to 10%. It’s just a really impressive drug. Until now, doctors didn’t really use medication to treat obesity; the drugs either didn’t work or had too many side effects. They recommended either diet and exercise (for easier cases) or bariatric surgery (for harder ones). Semaglutide marks the start of a new generation of weight loss drugs that are more clearly worthwhile. Modeling Semaglutide Accessibility 40% of Americans are obese - that’s 140 million people. Most of them would prefer to be less obese. Suppose that a quarter of them want semaglutide. That’s 35 million prescriptions. Semaglutide costs about $15,000 per year, multiply it out, that’s about $500 billion. Americans currently spend $300 billion per year total on prescription drugs. So if a quarter of the obese population got semaglutide, that would cost almost twice as much as all other drug spending combined. It would probably bankrupt half the health care industry. So . . . most people who want semaglutide won’t get it? Unclear. America’s current policy for controlling medical costs is to buy random things at random prices, then send all the bills to an illiterate reindeer-herder named Yagmuk, who burns them for warmth. Anything could happen! Right now, only about 50,000 Americans take semaglutide for obesity. I’m basing this off this report claiming “20,000 weekly US prescriptions” of Wegovy; since it’s taken once per week, maybe this means there are 20,000 users? Or maybe each prescription contains enough Wegovy to last a month and there are 80,000 users? I’m not sure, but it’s somewhere in the mid five digits, which I’m rounding to 50,000. That’s only 0.1% of the potential 35 million. The next few sections of this post are about why so few people are on semaglutide, and whether we should expect that to change. I’ll start by going over my model of what determines semaglutide use, then look at a Morgan Stanley projection of what will happen over the next decade. Step 1: Awareness I model semaglutide use as interest * awareness * prescription accessibility * affordability. I already randomly guessed interest at 25%, so the next step is awareness. How many people are aware of semaglutide? The answer is: a lot more now than when I first started writing this article! Novo Nordisk’s Wegovy Gets Surprise Endorsement From Elon Musk, says the headline. And here’s Google Trends: Semaglutide is now as searched-for on Google as Prozac or Viagra. Even if this is a temporary Musk-related spike, even pre-Musk it was getting a little above half their level. But Google Trends doesn’t exactly track awareness; few people search for Prozac these days precisely because everyone already knows what it is. So all this tells us is that there’s a lot of buzz around semaglutide. Suppose for the sake of argument that 5% of obese people have heard of this drug. Step 2: Prescription Accessibility The FDA says Wegovy is indicated for obesity, defined as BMI ≥ 30, or for people with BMI ≥ 27 and certain medical conditions. Does that mean that if you have that BMI, your doctor will give you a prescription? I think most doctors will want patients to try diet and exercise first. My experience as a doctor is that most obese people have already considered diet and exercise. Sometimes if you have a very compelling reason and a very well-thought out plan you can get them to try again. But usually they are obese because diet and exercise are hard for them, or don’t work for them, or some other reason besides “they never thought of it”. Still, I hear lots of stories about patient-doctor fights here. I assume this will happen with Wegovy too. Every doctor will have their own threshold for what amount of “already tried diet and exercise” is enough to justify a Wegovy prescription, and sometimes patients won’t meet that threshold. The history of medicine includes the following story many times: there’s some condition that doctors recommend lifestyle changes for. Then an exciting new medication comes out that treats the condition effectively. Over a generation or so, doctors go from demanding the lifestyle change, to gesturing at the lifestyle change before prescribing the medication, to mostly just prescribing the medication. We saw this with cholesterol and statins, with hypertension and ACE inhibitors, with depression and SSRIs. You can form your own opinion on whether this is good or bad, but we’re probably in the very beginning of this process with obesity. Opinions will be all over the map for a while before the inevitable pharma company victory makes everyone agree that semaglutide is first-line therapy. …except that this time, Silicon Valley is short-circuiting the process with fly-by-night telemedicine companies that guarantee you’ll get the drugs you want. For example, NextMed charges $138/month ($99 first month only!) for a guaranteed GLP-1 agonist prescription, plus “support and messaging with expert doctors”. The DEA sometimes shuts these groups down when they start playing around with controlled substances (eg addictive drugs like Adderall), but Wegovy isn’t controlled, and the government probably doesn’t care that much here. These services guarantee that people with money will be able to circumvent conservative doctors and access a prescription. Only 75% of Americans have PCPs at all. If we assume half of them will eventually be able to get a Wegovy prescription from their doctor, that’s 37.5%. Step 3: Affordability Semaglutide costs $15,000/year. Well-off people like Elon Musk might be able to pay that out-of-pocket, but most people will probably need insurance coverage. Right now this is spotty. Medicare doesn’t cover obesity drugs. This isn’t a reaction to the threat of semaglutide-related cost explosions - they’re not that smart. I think Medicare laws were just written in the old days when people were less likely to think of obesity as a disease. Is it time for change? Some Congressmen have proposed a very noble-sounding law telling Medicare and Medicaid to start covering weight loss drugs. I‘m sure this is out of deep compassion for America’s obese population and not because it would make pharma companies one billion zillion dollars. One of the Congressmen even has the last name “Kind!” Some pharma lobbyist probably got a bonus for that one. Private insurers mostly have to cover whatever Medicare does, but they can choose whether or not to include extra non-Medicare-covered drugs. Some have chosen to cover semaglutide under some conditions. Others would prefer not to cover it, but can be scared into covering it by the magic words “medical necessity”. Overall I don’t understand the laws here beyond that maybe they’ll cover it and maybe they won’t. Here, too, it might be time for change. The New York Times is publishing articles trying to convince us that private insurances not covering semaglutide is an outrage. Here in the tiny gray text, I want to take a second to complain about this article. It notes that Wegovy (semaglutide for obesity) costs more per prescription than Ozempic (semaglutide for diabetes), and calls this “a gross inequity”, accusing Novo Nordisk of “charg[ing] people more for the same drug because of their obesity”. But the obesity prescription is higher dose than the diabetes prescription! Milligram per milligram, Wegovy costs *less* than Ozempic! A steelmanned version of the NYT might object - don’t most of the costs come from the intellectual property and not the manufacturing, so that dose shouldn’t matter? Yes, but if you made the obesity version cost too much less per milligram than the diabetes version, then diabetics would cheat the system by buying the obesity version and splitting it into smaller doses! Insurances that do cover it may require extra documentation that the patient has tried lots of diet and exercise, maybe including some official diet-and-exercise program like WeightWatchers. They might also want documentation that patients have tried cheaper earlier-generation weight loss drugs without success. Even when insurances do cover semaglutide, copays may be very high. I have a pretty minimal insurance and it looks like if I got semaglutide my copay would be about $500/month until I reach my out of pocket limit. Harsh. People with better insurances might get hit less hard, but I don’t think anyone will be picking this up for cheap. Let’s say only 5% of people who clear all previous hurdles can afford the drug. How Many People Get Semaglutide? 140 million obese Americans * 25% interested * 5% know of semaglutide’s existence * 37.5% can get prescriptions * 5% can afford it = 33,000, which is a pretty good match for the 50,000 estimated prescriptions. I didn’t even fudge the numbers to come out right, it just happened. The Coming Decade As a service to pharma investors, Morgan Stanley modeled the economic future of obesity medications over the next decade. Their headline result: semaglutide and various semaglutide-copycat-drugs will be a $30 billion market by 2030. That’s less than the $500 billion disaster I was afraid of! But still almost 10% of all US drug spending! Here are two core analyses from the report: The first analysis asks “what if doctors medicalized obesity as comprehensively as they’ve medicalized hypertension and high cholesterol?” That is: what if we put in a society-wide effort to get every obese person to a doctor, and after only a little diet and exercise, the doctor puts them on a medication? They find that the US obesity market would multiply by a factor of 25, to about $87 billion/year. The second analysis is a more realistic projection for the next decade. Two things stand out. First, the number of patients on Wegovy or related medications goes from an estimated 46,910 now (pretty close to my 50,000 estimate!) to 11.3 million in 2030. Second, the cost per prescription goes from $15,000/year to about $4,000 year. Let’s look at this second change in more detail. Right now semaglutide is literally in a class of its own for weight loss. But remember, it started as a GLP-1 agonist diabetes drug. And there are other GLP-1 agonists already in use for diabetes. Novo Nordisk’s competitor Eli Lilly owns a closely related molecule, tirzepatide (Mounjaro®). They’ve already done studies showing it also works very well for weight loss - if anything even better than semaglutide - and they’re expected to get FDA approval to market it as a weight loss medication next year. Although capitalism fans might expect the presence of two competing drugs to immediately drive down prices, this is mysteriously not how things work in health care and prices will probably stay the same in the short term. But several other companies are working on semaglutide-like drugs, some will be cheaper to produce than semaglutide, and Morgan Stanley expects that this stronger level of competition will eventually drive costs down to $350/month ($4,000/year) by 2030. “Mounjaro” sounds like the playful animal sidekick in a Disney movie. From a purely economic perspective, semaglutide costs the health system money (because it’s expensive) but also saves the health system money (because we don’t have to pay for obesity consequences like diabetes and heart attacks). Which effect wins out? According to the Institute for Clinical and Economic Review, benefits would outweigh costs if semaglutide cost less than about $8,000/year. Since it costs $15,000 year now, it’s not cost effective. But if Morgan Stanley’s model comes true and it costs $4,000/year in 2030, then it will be cost effective. So at some point, Medicare (and so insurance companies) may start covering it more out of self-interest. I can’t tell whether the model takes this into account or not. (there’s also a third-level effect where it costs the health system money again, because it prevents people from dying of obesity-related complications, and dead people stop needing expensive health care. I think health economists are supposed to ignore this level.) 11.3 million prescriptions at $4,000/year comes to $45 billion, but Morgan Stanley expects that not everyone will fill their prescriptions consistently or stay on the medication the same amount of time, leading to their $31 billion figure. Towards The Glorious Post-Obesity Transhuman Future The Morgan Stanley report shows that even the greediest pharma investors, openly plotting to medicalize obesity, can’t bring themselves to believe in more than 11 million US semaglutide patients by 2030. That’s less than 10% of the US obese population. Isn’t that kind of disappointing? We’ve got > 100 million people dealing with a condition that not only makes them unhealthy, but also causes them psychological distress, and makes lots of people low-grade disappointed in and repulsed by our society. And we’ve got an effective drug that treats the condition. And we’re going to use it on less than 10% of the people involved? In 2032, semaglutide goes off-patent. It will probably take a few years to sort out legal issues and ramp up generic production, but by the mid-2030s, its price will go way down. I don’t think there are technical barriers to getting it down as low as $10 - $100 per month. By then, maybe there will be even more exciting branded weight loss drugs for wealthy people to choose from. But at the very least, semaglutide itself should become much more widely available even to poor or uninsured patients. I’m not sure what will happen. Will there be an inflection point, where so many people use semaglutide that obesity becomes unusual again, and then the remaining obese people start using it just to fit in? Will obesity become an optional fashion statement, like shaving your head or getting a tattoo? Or will semaglutide end up disappointing us in some way, like so many promising drugs have before? I come at semaglutide from a transhumanist perspective. I want to hack genetics and biology until everyone is as tall as they want, as strong as they want, as smart as they want, and whatever gender they want. If you want wings, you should be able to have wings. And yes, part of this vision is everyone having the weight they want. I’m not sure this will happen, but for the first time I can see a clear path to how it might. Postscript 1: Should You Take Semaglutide? I can’t answer this, please ask your doctor. But I do want to add that there are potential side effects I haven’t mentioned in this post, including nausea, gastrointestinal problems, pancreatitis, and kidney problems. Semaglutide has been accused of slightly increasing risk of pancreatic and thyroid cancers. Studies have found trends in this direction, but these conditions are so rare that even over thousands of patients over many years, the increase hasn’t yet reached clear statistical significance. The current consensus position is that it may increase thyroid cancer by a tiny amount not relevant to most patients, and that it probably doesn’t increase pancreatic cancer. I think my father has looked over these data more and is less sure than other people about the lack of pancreatic cancer risk, but he can’t get the resources he needs to prove anything, and I can’t remember his exact argument. More broadly: like all medications, semaglutide has benefits and risks, and you shouldn’t blindly take it after reading one blog article. Postscript 2: Is There A Way To Cheat The System To Get Semaglutide For Lower Cost? Health care is much like airline tickets: everyone pays a different price for everything and there’s usually a secret way to get what you want for much less money. Is this true of semaglutide? Pharma company Novo Nordisk offers a Savings Card that they say brings the price down to as low as $25 per month. I’m a little suspicious of this - pharma company offers are rarely as good as they sound - but I don’t notice any obvious tricks in this one and it should probably be your first bet. This startup claims that they can get insured people semaglutide for a $25/month copay “after their deductible is met” by negotiating with the insurance company very effectively. I can’t imagine how that works or what they have to negotiate with, but they seem pretty convinced, so I would welcome more information. Otherwise, you don’t have many great options. Although there are two older forms of semaglutide not FDA-approved for weight loss - Ozempic and Rybelsus - these are both more expensive, milligram per milligram, than Wegovy itself. Canada is also of no help. The usual Canadian pharmacies don’t seem to carry Wegovy, and charge about the same amount for Ozempic as American pharmacies do. This article in Drug Discovery Trends says that compounding pharmacies have been selling semaglutide for $300/month, less than a quarter of the sticker price. This is a bit confusing: compounding pharmacies are small local operations permitted to dispense unusual medications by mixing existing ones together in nonstandard ways. They’re arguing that they can legally dispense the semaglutide because they’re mixing it with vitamins, which, fine, but how are they getting it in the first place? Everyone else seems as confused as I am: "Nobody knows how [compounding pharmacies are] getting it," said Karl Nadolsky, an endocrinologist at Spectrum Health. "Who's making it? [The pharma company that makes it] Novo [Nordisk]'s not giving it to them. They're the ones with the rights to the molecule, so how is anybody getting semaglutide?" Has nobody asked compounding pharmacists about this? Do they have a conspiracy of silence? Does the FDA sometimes send their goons in to extract the information, but the compounding pharmacists compound sleeping gas / smoke grenades and vanish into the night? Anyway, the usual authorities warn you not to take compounded semaglutide under any circumstances, but they’re the same people who tell you never to buy drugs from a Canadian pharmacy because they might be adulterated. You can decide how much you want to trust them. Postscript 3: What About Europe And The Rest Of The World? Countries that are not the US usually negotiate with pharmaceutical companies over price. Because of some combination of “negotiation works” and “they are free-riding off Americans’ hard work”, they usually get much lower prices. What does semaglutide cost elsewhere? This is hard to find out because government health agencies sometimes keep their prices secret, plus Wegovy mostly isn’t available in other countries yet. The only information I could find was from Britain, which is in the process of making Wegovy available to patients. It looks like NHS will “restrict the expensive drug’s availability to very obese people attending specialist weight-loss clinics”, but that it might be possible to get it from private clinics for £199/month = £2400/year. Wegovy has been approved in the EU but doesn’t seem to have made it there yet. I can’t find any information about any other country. Non-weight-loss-indicated versions of semaglutide are available in many countries, but I wouldn’t expect their health care systems to be flexible about redirecting it for weight. Canadian regulators have approved Wegovy, but it doesn’t seem to be available there yet. I haven’t seen any evidence that Ozempic costs less in Canada than it does in the US, and I’m not sure why. Maybe the pharma companies have figured out that anything that happens in Canada gets imported into the US, and they’re playing hardball this time. I don’t know whether Canadians will be able to get it for cheaper than Americans or not. Postscript 4: Predictions (all predictions are conditional on no singularity or global catastrophe) 10 million Americans on semaglutide (or yet-to-be-approved equally good or superior alternatives) by 2030: 75%

Inline links: https://substackcdn.com/image/fetch/$s_!gShh!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2Fe4b4ffd4-3d5b-445c-961d-f562ca14ac0f_818x220.png, Source, here, in the comments, lose more weight, this report, Novo Nordisk’s Wegovy Gets Surprise Endorsement From Elon Musk, https://substackcdn.com/image/fetch/$s_!RABx!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F366df26d-e420-431d-8034-e2c4a6a8de60_1149x471.png, NextMed, a very noble-sounding law, https://substackcdn.com/image/fetch/$s_!l_X7!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F1dbb9e98-6e07-4237-988e-3b7a61af3e5a_1381x834.png, is publishing articles, https://substackcdn.com/image/fetch/$s_!R-zS!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F0f24b293-27de-462a-84fd-bed2ba7cf07f_1723x831.png, https://substackcdn.com/image/fetch/$s_!zSOS!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F0906b28a-1ad4-421d-a055-87ed95db59ce_918x261.png, https://substackcdn.com/image/fetch/$s_!QJj9!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2Fb966f730-6b24-48e1-98b1-e710cda9264c_903x656.png, this is mysteriously not how things work in health care, https://substackcdn.com/image/fetch/$s_!5poy!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2Fc201f05a-7d1f-4738-911f-11d0d051adf9_2880x1562.png, Institute for Clinical and Economic Review, don’t think there are technical barriers, offers a Savings Card, This startup, about the same amount for Ozempic, This article in Drug Discovery Trends, Everyone else seems as confused as I am, NHS will, private clinics

Semaglutide is now as searched-for on Google as Prozac or Viagra. Even if this is a temporary Musk-related spike, even pre-Musk it was getting a little above half their level. But Google Trends doesn’t exactly track awareness; few people search for Prozac these days precisely because everyone already knows what it is. So all this tells us is that there’s a lot of buzz around semaglutide. Suppose for the sake of argument that 5% of obese people have heard of this drug. Step 2: Prescription Accessibility The FDA says Wegovy is indicated for obesity, defined as BMI ≥ 30, or for people with BMI ≥ 27 and certain medical conditions. Does that mean that if you have that BMI, your doctor will give you a prescription? I think most doctors will want patients to try diet and exercise first. My experience as a doctor is that most obese people have already considered diet and exercise. Sometimes if you have a very compelling reason and a very well-thought out plan you can get them to try again. But usually they are obese because diet and exercise are hard for them, or don’t work for them, or some other reason besides “they never thought of it”. Still, I hear lots of stories about patient-doctor fights here. I assume this will happen with Wegovy too. Every doctor will have their own threshold for what amount of “already tried diet and exercise” is enough to justify a Wegovy prescription, and sometimes patients won’t meet that threshold. The history of medicine includes the following story many times: there’s some condition that doctors recommend lifestyle changes for. Then an exciting new medication comes out that treats the condition effectively. Over a generation or so, doctors go from demanding the lifestyle change, to gesturing at the lifestyle change before prescribing the medication, to mostly just prescribing the medication. We saw this with cholesterol and statins, with hypertension and ACE inhibitors, with depression and SSRIs. You can form your own opinion on whether this is good or bad, but we’re probably in the very beginning of this process with obesity. Opinions will be all over the map for a while before the inevitable pharma company victory makes everyone agree that semaglutide is first-line therapy. …except that this time, Silicon Valley is short-circuiting the process with fly-by-night telemedicine companies that guarantee you’ll get the drugs you want. For example, NextMed charges $138/month ($99 first month only!) for a guaranteed GLP-1 agonist prescription, plus “support and messaging with expert doctors”. The DEA sometimes shuts these groups down when they start playing around with controlled substances (eg addictive drugs like Adderall), but Wegovy isn’t controlled, and the government probably doesn’t care that much here. These services guarantee that people with money will be able to circumvent conservative doctors and access a prescription. Only 75% of Americans have PCPs at all. If we assume half of them will eventually be able to get a Wegovy prescription from their doctor, that’s 37.5%. Step 3: Affordability Semaglutide costs $15,000/year. Well-off people like Elon Musk might be able to pay that out-of-pocket, but most people will probably need insurance coverage. Right now this is spotty. Medicare doesn’t cover obesity drugs. This isn’t a reaction to the threat of semaglutide-related cost explosions - they’re not that smart. I think Medicare laws were just written in the old days when people were less likely to think of obesity as a disease. Is it time for change? Some Congressmen have proposed a very noble-sounding law telling Medicare and Medicaid to start covering weight loss drugs. I‘m sure this is out of deep compassion for America’s obese population and not because it would make pharma companies one billion zillion dollars. One of the Congressmen even has the last name “Kind!” Some pharma lobbyist probably got a bonus for that one. Private insurers mostly have to cover whatever Medicare does, but they can choose whether or not to include extra non-Medicare-covered drugs. Some have chosen to cover semaglutide under some conditions. Others would prefer not to cover it, but can be scared into covering it by the magic words “medical necessity”. Overall I don’t understand the laws here beyond that maybe they’ll cover it and maybe they won’t. Here, too, it might be time for change. The New York Times is publishing articles trying to convince us that private insurances not covering semaglutide is an outrage. Here in the tiny gray text, I want to take a second to complain about this article. It notes that Wegovy (semaglutide for obesity) costs more per prescription than Ozempic (semaglutide for diabetes), and calls this “a gross inequity”, accusing Novo Nordisk of “charg[ing] people more for the same drug because of their obesity”. But the obesity prescription is higher dose than the diabetes prescription! Milligram per milligram, Wegovy costs *less* than Ozempic! A steelmanned version of the NYT might object - don’t most of the costs come from the intellectual property and not the manufacturing, so that dose shouldn’t matter? Yes, but if you made the obesity version cost too much less per milligram than the diabetes version, then diabetics would cheat the system by buying the obesity version and splitting it into smaller doses! Insurances that do cover it may require extra documentation that the patient has tried lots of diet and exercise, maybe including some official diet-and-exercise program like WeightWatchers. They might also want documentation that patients have tried cheaper earlier-generation weight loss drugs without success. Even when insurances do cover semaglutide, copays may be very high. I have a pretty minimal insurance and it looks like if I got semaglutide my copay would be about $500/month until I reach my out of pocket limit. Harsh. People with better insurances might get hit less hard, but I don’t think anyone will be picking this up for cheap. Let’s say only 5% of people who clear all previous hurdles can afford the drug. How Many People Get Semaglutide? 140 million obese Americans * 25% interested * 5% know of semaglutide’s existence * 37.5% can get prescriptions * 5% can afford it = 33,000, which is a pretty good match for the 50,000 estimated prescriptions. I didn’t even fudge the numbers to come out right, it just happened. The Coming Decade As a service to pharma investors, Morgan Stanley modeled the economic future of obesity medications over the next decade. Their headline result: semaglutide and various semaglutide-copycat-drugs will be a $30 billion market by 2030. That’s less than the $500 billion disaster I was afraid of! But still almost 10% of all US drug spending! Here are two core analyses from the report: The first analysis asks “what if doctors medicalized obesity as comprehensively as they’ve medicalized hypertension and high cholesterol?” That is: what if we put in a society-wide effort to get every obese person to a doctor, and after only a little diet and exercise, the doctor puts them on a medication? They find that the US obesity market would multiply by a factor of 25, to about $87 billion/year. The second analysis is a more realistic projection for the next decade. Two things stand out. First, the number of patients on Wegovy or related medications goes from an estimated 46,910 now (pretty close to my 50,000 estimate!) to 11.3 million in 2030. Second, the cost per prescription goes from $15,000/year to about $4,000 year. Let’s look at this second change in more detail. Right now semaglutide is literally in a class of its own for weight loss. But remember, it started as a GLP-1 agonist diabetes drug. And there are other GLP-1 agonists already in use for diabetes. Novo Nordisk’s competitor Eli Lilly owns a closely related molecule, tirzepatide (Mounjaro®). They’ve already done studies showing it also works very well for weight loss - if anything even better than semaglutide - and they’re expected to get FDA approval to market it as a weight loss medication next year. Although capitalism fans might expect the presence of two competing drugs to immediately drive down prices, this is mysteriously not how things work in health care and prices will probably stay the same in the short term. But several other companies are working on semaglutide-like drugs, some will be cheaper to produce than semaglutide, and Morgan Stanley expects that this stronger level of competition will eventually drive costs down to $350/month ($4,000/year) by 2030. “Mounjaro” sounds like the playful animal sidekick in a Disney movie. From a purely economic perspective, semaglutide costs the health system money (because it’s expensive) but also saves the health system money (because we don’t have to pay for obesity consequences like diabetes and heart attacks). Which effect wins out? According to the Institute for Clinical and Economic Review, benefits would outweigh costs if semaglutide cost less than about $8,000/year. Since it costs $15,000 year now, it’s not cost effective. But if Morgan Stanley’s model comes true and it costs $4,000/year in 2030, then it will be cost effective. So at some point, Medicare (and so insurance companies) may start covering it more out of self-interest. I can’t tell whether the model takes this into account or not. (there’s also a third-level effect where it costs the health system money again, because it prevents people from dying of obesity-related complications, and dead people stop needing expensive health care. I think health economists are supposed to ignore this level.) 11.3 million prescriptions at $4,000/year comes to $45 billion, but Morgan Stanley expects that not everyone will fill their prescriptions consistently or stay on the medication the same amount of time, leading to their $31 billion figure. Towards The Glorious Post-Obesity Transhuman Future The Morgan Stanley report shows that even the greediest pharma investors, openly plotting to medicalize obesity, can’t bring themselves to believe in more than 11 million US semaglutide patients by 2030. That’s less than 10% of the US obese population. Isn’t that kind of disappointing? We’ve got > 100 million people dealing with a condition that not only makes them unhealthy, but also causes them psychological distress, and makes lots of people low-grade disappointed in and repulsed by our society. And we’ve got an effective drug that treats the condition. And we’re going to use it on less than 10% of the people involved? In 2032, semaglutide goes off-patent. It will probably take a few years to sort out legal issues and ramp up generic production, but by the mid-2030s, its price will go way down. I don’t think there are technical barriers to getting it down as low as $10 - $100 per month. By then, maybe there will be even more exciting branded weight loss drugs for wealthy people to choose from. But at the very least, semaglutide itself should become much more widely available even to poor or uninsured patients. I’m not sure what will happen. Will there be an inflection point, where so many people use semaglutide that obesity becomes unusual again, and then the remaining obese people start using it just to fit in? Will obesity become an optional fashion statement, like shaving your head or getting a tattoo? Or will semaglutide end up disappointing us in some way, like so many promising drugs have before? I come at semaglutide from a transhumanist perspective. I want to hack genetics and biology until everyone is as tall as they want, as strong as they want, as smart as they want, and whatever gender they want. If you want wings, you should be able to have wings. And yes, part of this vision is everyone having the weight they want. I’m not sure this will happen, but for the first time I can see a clear path to how it might. Postscript 1: Should You Take Semaglutide? I can’t answer this, please ask your doctor. But I do want to add that there are potential side effects I haven’t mentioned in this post, including nausea, gastrointestinal problems, pancreatitis, and kidney problems. Semaglutide has been accused of slightly increasing risk of pancreatic and thyroid cancers. Studies have found trends in this direction, but these conditions are so rare that even over thousands of patients over many years, the increase hasn’t yet reached clear statistical significance. The current consensus position is that it may increase thyroid cancer by a tiny amount not relevant to most patients, and that it probably doesn’t increase pancreatic cancer. I think my father has looked over these data more and is less sure than other people about the lack of pancreatic cancer risk, but he can’t get the resources he needs to prove anything, and I can’t remember his exact argument. More broadly: like all medications, semaglutide has benefits and risks, and you shouldn’t blindly take it after reading one blog article. Postscript 2: Is There A Way To Cheat The System To Get Semaglutide For Lower Cost? Health care is much like airline tickets: everyone pays a different price for everything and there’s usually a secret way to get what you want for much less money. Is this true of semaglutide? Pharma company Novo Nordisk offers a Savings Card that they say brings the price down to as low as $25 per month. I’m a little suspicious of this - pharma company offers are rarely as good as they sound - but I don’t notice any obvious tricks in this one and it should probably be your first bet. This startup claims that they can get insured people semaglutide for a $25/month copay “after their deductible is met” by negotiating with the insurance company very effectively. I can’t imagine how that works or what they have to negotiate with, but they seem pretty convinced, so I would welcome more information. Otherwise, you don’t have many great options. Although there are two older forms of semaglutide not FDA-approved for weight loss - Ozempic and Rybelsus - these are both more expensive, milligram per milligram, than Wegovy itself. Canada is also of no help. The usual Canadian pharmacies don’t seem to carry Wegovy, and charge about the same amount for Ozempic as American pharmacies do. This article in Drug Discovery Trends says that compounding pharmacies have been selling semaglutide for $300/month, less than a quarter of the sticker price. This is a bit confusing: compounding pharmacies are small local operations permitted to dispense unusual medications by mixing existing ones together in nonstandard ways. They’re arguing that they can legally dispense the semaglutide because they’re mixing it with vitamins, which, fine, but how are they getting it in the first place? Everyone else seems as confused as I am: "Nobody knows how [compounding pharmacies are] getting it," said Karl Nadolsky, an endocrinologist at Spectrum Health. "Who's making it? [The pharma company that makes it] Novo [Nordisk]'s not giving it to them. They're the ones with the rights to the molecule, so how is anybody getting semaglutide?" Has nobody asked compounding pharmacists about this? Do they have a conspiracy of silence? Does the FDA sometimes send their goons in to extract the information, but the compounding pharmacists compound sleeping gas / smoke grenades and vanish into the night? Anyway, the usual authorities warn you not to take compounded semaglutide under any circumstances, but they’re the same people who tell you never to buy drugs from a Canadian pharmacy because they might be adulterated. You can decide how much you want to trust them. Postscript 3: What About Europe And The Rest Of The World? Countries that are not the US usually negotiate with pharmaceutical companies over price. Because of some combination of “negotiation works” and “they are free-riding off Americans’ hard work”, they usually get much lower prices. What does semaglutide cost elsewhere? This is hard to find out because government health agencies sometimes keep their prices secret, plus Wegovy mostly isn’t available in other countries yet. The only information I could find was from Britain, which is in the process of making Wegovy available to patients. It looks like NHS will “restrict the expensive drug’s availability to very obese people attending specialist weight-loss clinics”, but that it might be possible to get it from private clinics for £199/month = £2400/year. Wegovy has been approved in the EU but doesn’t seem to have made it there yet. I can’t find any information about any other country. Non-weight-loss-indicated versions of semaglutide are available in many countries, but I wouldn’t expect their health care systems to be flexible about redirecting it for weight. Canadian regulators have approved Wegovy, but it doesn’t seem to be available there yet. I haven’t seen any evidence that Ozempic costs less in Canada than it does in the US, and I’m not sure why. Maybe the pharma companies have figured out that anything that happens in Canada gets imported into the US, and they’re playing hardball this time. I don’t know whether Canadians will be able to get it for cheaper than Americans or not. Postscript 4: Predictions (all predictions are conditional on no singularity or global catastrophe) 10 million Americans on semaglutide (or yet-to-be-approved equally good or superior alternatives) by 2030: 75%

Inline links: NextMed, a very noble-sounding law, https://substackcdn.com/image/fetch/$s_!l_X7!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F1dbb9e98-6e07-4237-988e-3b7a61af3e5a_1381x834.png, is publishing articles, https://substackcdn.com/image/fetch/$s_!R-zS!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F0f24b293-27de-462a-84fd-bed2ba7cf07f_1723x831.png, modeled the economic future of obesity medications over the next decade, https://substackcdn.com/image/fetch/$s_!zSOS!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F0906b28a-1ad4-421d-a055-87ed95db59ce_918x261.png, https://substackcdn.com/image/fetch/$s_!QJj9!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2Fb966f730-6b24-48e1-98b1-e710cda9264c_903x656.png, this is mysteriously not how things work in health care, https://substackcdn.com/image/fetch/$s_!5poy!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2Fc201f05a-7d1f-4738-911f-11d0d051adf9_2880x1562.png, Institute for Clinical and Economic Review, don’t think there are technical barriers, offers a Savings Card, This startup, about the same amount for Ozempic, This article in Drug Discovery Trends, Everyone else seems as confused as I am, NHS will, private clinics

Links For March 2023

March 10, 2023 · Original source

15: Possibly related: Elon Musk appears to express regret for his role in accelerating AI: “It’s quite a dangerous technology - I fear I may have done some things to accelerate it.”

I’d hoped he had learned his lesson, but he’s since announced plans to create an “anti-woke” GPT competitor which might also be more “open”. I stick to my 2015 post on the issue.

Inline links: announced plans to create an “anti-woke” GPT competitor, my 2015 post on the issue

30: Facebook And Instagram Are Testing Selling You Bluechecks For $12 A Month. Musk’s two highest-profile Twitter changes - firing lots of people and selling bluechecks - seem to be going well and even getting adopted by other companies. I can see a case for everyone apologizing and agreeing Musk is doing a good job with Twitter in a year, although prediction markets haven’t shifted much since December.

Inline links: Facebook And Instagram Are Testing Selling You Bluechecks For $12 A Month, haven’t, shifted

Links For May 2023

June 01, 2023 · Original source

It’s fascinating that even after a year of very bad publicity, Musk remains most respected (although maybe this is just because he’s on a list of “political figures” without being a politician, and people hate politicians?). But it’s equally interesting that Trump and DeSantis both do better than any liberal. Did this poll just oversample conservatives? I don’t think so - its relative ratings line up pretty well with RCP, except for Trump, who RCP has about as low as Biden. I think more likely conservatives actually like Trump and DeSantis, whereas liberals merely tolerate Biden and Clinton, and this gives them a bigger favorability advantage than election results would suggest.

Inline links: line up pretty well with RCP

Contra The xAI Alignment Plan

July 17, 2023 · Original source

Elon Musk has a new AI company, xAI. I appreciate that he seems very concerned about alignment. From his Twitter Spaces discussion:

Inline links: his Twitter Spaces discussion

Finally, consider one last advantage of “follow human orders” over “be maximally curious”. Suppose Elon Musk programs an AI to follow his orders. Then he can order it to try being maximally curious. If it starts vivisecting people, he can say “Stop!” and it will. But if he starts by telling it to be maximally curious, he loses all control over it in the future.

They say that everything we create is made in our own image. Elon Musk is pretty close to maximally curious and I respect his desire to make an AI that’s like him. But for now he should swallow his pride and do the same extremely boring thing everyone else is doing: basic research aimed at eventually getting an AI that listens to us at all.

Book Review: Elon Musk

September 13, 2023 · Original source

Elon Musk: Tesla, SpaceX, And The Quest For A Fantastic Future delights in its refusal to resolve the dissonance. Musk has always been exactly the same person he is now, and exactly what he looks like. He is without deception, without subtlety, without unexpected depths.

Inline links: Elon Musk: Tesla, SpaceX, And The Quest For A Fantastic Future

A 4D chessmaster is someone who wins by being smarter than everyone else. I think Elon Musk is 1-in-1,000 level intelligent - which is great, but means there are still 300,000 people in America smarter than he is.

So many people have gone broke betting against Elon Musk that I’m going with “probably he’ll do a good job”.

Highlights From The Comments On Elon Musk

September 18, 2023 · Original source

[original post: Book Review: Elon Musk]

Inline links: Book Review: Elon Musk

I don't think most people know the general state of aerospace industry CEO's and managers. Boeing is currently run by a former hedge fund guy with a degree in accounting. Relative to the industry, Elon Musk's public statements demonstrate enormous engineering acumen for an exec. I've got a master's degree in AE and whenever he's said something in aerodynamics or structures I'm like yep, that's about right. I remember a while back Musk said something about the 787's batteries catching on fire and some MIT prof, world expert on batteries, was quoted saying, "I would have said exactly the same thing."

The new Elon Musk biography says that Musk’s SAT scores were 730 math, 670 verbal. This are good-but-not-great scores now, but epursimuove reminds us that Musk took the SATs before 1995, when the scores were calculated differently and high scores were harder to get. Based on the pre-1995 norms, 1400 puts him at the 99.1st percentile of test-takers. But only a third of students took the SAT during 1994 (the year I have good data for), and probably these were selected for intelligence. So Elon is somewhat higher than the 99.1st percentile of the general population. I think this suggests a total IQ somewhere between 136 and 140, probably around 130 verbal and 145 - 150 performance/math. Sorry, making the adjustments described here, it’s more like 130 - 135 total, 135 - 145 math.

Inline links: says, epursimuove reminds us, here

Open Thread 295

September 25, 2023 · Original source

3: Comments of the week: does SpaceX outperform typical aerospace contractors because of the difference between agile and waterfall engineering? And are Musk’s mental health issues related to chronic pain?

Inline links: does SpaceX outperform typical aerospace contractors because of the difference between agile and waterfall engineering, are Musk’s mental health issues related to chronic pain

December 05, 2023 · Original source

Or it could have nothing to do with that. Maybe it wasn’t a Machiavellian factional decision at all. Bret Taylor was the head of the Twitter board that negotiated with Musk; people think he did a good job. He might just be “generic person who’s good at boards”. Larry Summers is also a generic person who’s probably good at boards. Adam D’Angelo could credibly claim to be the most moderate (neither explicitly an Altman pawn nor explicitly a safetyist) person on the last board, and if they were going for a board of moderates, he could be there to provide continuity.

January 30, 2024 · Original source

Both 15% and 32% are low numbers, but Israelis in the comments bring up that there aren’t scheduled elections in 2024. So if Bibi didn’t resign and his coalition partners didn’t desert him, he could potentially cling on. And nobody clings to power more ferociously than Benjamin Netanyahu. That recent spike comes from Musk’s claim three hours ago that the first Neuralink has been implanted into a human being.

Inline links: Musk’s claim three hours ago

That recent spike comes from Musk’s claim three hours ago that the first Neuralink has been implanted into a human being.

Inline links: Musk’s claim three hours ago

Open Thread 340

July 29, 2024 · Original source

GJM finds that Musk’s grandfather was a local leader of Technocracy Inc, not (as I wrote) a national leader.

Inline links: finds that

Mantic Monday: Judgment Day

November 05, 2024 · Original source

An even better question: if Musk did get a high-level position, would it go well? I would bet 30-70 no: he’s done some amazing things with his businesses, but the success rate for businesspeople trying to transfer their skills to government is low. Here I’m most moved by the example of Herbert Hoover, who started out as the Elon Musk of his day, did a good job as Commerce Secretary, but wasn’t able to cut it as President - he was too much of a move-fast-and-break-things autocratic CEO to handle a situation where he had to make compromises, appease stakeholders, and slowly build coalitions. You could imagine Trump thinking really hard about how to carve out a role that played to Elon’s strengths while shielding him from his weaknesses, but - no, sorry, I did a bad job starting this sentence, you can’t actually imagine Trump doing that.

Yet in the end, everything is so perfectly balanced that the sum total of these luminaries refuse to say which side of even we’re on. The nation balances on a knife’s edge. Eli Lilly stock moons. A red sun hangs over Philadelphia, where American democracy began and may yet end. A man walks into a diner just before closing time. He looks like a good tipper. The waitress was hoping to leave early and go vote. She decides against. Seven trumpets sound; seven seals are opened; there is silence in Heaven for the space of about half an hour. As George RR Martin put it, “God flips a coin and the world holds its breath.” Tomorrow - if we are so lucky - there will be a result. The great function that has consumed us for so long will return 0 or 1. The pundits who guessed 51-49 will be hailed as prophets; the pundits who guessed 49-51 will get bullied out of public life. The winner’s campaign operatives will be praised as world-historic geniuses, the loser’s mocked forever as utter nincompoops. Thousands of lifelong public servants who backed Mr. 49% will be tossed from DC like used toilet paper and replaced with thousands of hacks who backed Mr. 51%. Funding streams will go dry. Whole lands will turn to economic deserts. Fortunes will be destroyed. A few people will make good on their exile and suicide threats. Most won’t. The Union will either survive or not. If it survives, we’ll do it all over again four years later. A red sun sets over DC. The marble monuments are stained crimson; the statues of Lincoln and Jefferson and the rest look like they writhe in hellfire. The people seclude themselves in their houses. A city where even the Christians are atheist kneels in prayer. On some level, they know - we know - it was never just about choosing a leader. It was all for this - the same urge that drove the games of the Colosseum and sacrifices of Tenochtitlan. The need for a single moment of unconditioned reality. For one evening, the people of the richest and most secure nation in history, fat off the spoils of six continents, will know the same fear as the starving Catalhuyuk farmer, staring at the sky, wondering if the rains will come. For one evening, everyone - rich or poor, religious or secular, Democrat or Republican - will join in the prayer of the poet: “Judge of the Nations, spare us yet Lest we forget - lest we forget!” Don’t Blame Me, I Voted For Kodos Metaculus uses experimental “conditional forecasts” to determine the consequences of a Trump/Harris victory. How it works (example): you set up two forecasts: If Trump wins, will China invade Taiwan?

Inline links: the prayer of the poet, experimental “conditional forecasts”, example

The market defines “major” as five hundred participants causing either $1 million in damage or 10 hospitalizations/deaths. This market is priced higher than Manifold’s chance that Trump loses, suggesting a ~5% chance that the Democrats riot (or that Republicans win but riot anyway). I think no, because Musk is too busy to accept another job (and would tell Trump this), or if he did accept another job it would be some vague czar position rather than falling along cabinet lines.

Bureaucracy Isn't Measured In Bureaucrats

January 09, 2025 · Original source

That’s worse! A few years ago, I debated Kevin Drum about (what I considered) a particularly egregious case where the FDA dragged its feet approving a life-saving medication. Drum argued that the FDA had behaved well. In support, he found some quotes from the doctor working on the medication, who praised all the FDA bureaucrats she had interacted with, calling them extremely helpful. This bothered me for a while, until I realized that of course it was true. In the model above, each bureaucrat processes ten forms. If the bureaucrats are benevolent, this might look like talking to the doctors, walking them through the process of figuring out their ten forms, and doing the work to add their ten forms to the FDA’s growing pile of evidence supporting the application. All of this co-exists comfortably with the insight that making doctors fill out a thousand forms before they can use a medication is an impediment to medical progress. This really sunk in for me when I read an article about the fall of Afghanistan to the Taliban in 2021. Many Afghans had collaborated with the Americans, eg as translators, in exchange for a promise of US citizenship. As the Taliban advanced, they called in the promise, begging to be allowed to flee to America before they got punished as traitors. The article focused on a heroic effort by certain immigration bureaucrats, who worked around the clock with minimal sleep for the last few weeks before Kabul fell, trying to get the citizenship forms filled in and approved for as many translators as possible. It made an impression on me because nobody was opposed to the translators getting citizenship, and the bureaucrats were themselves the people in charge of approving citizenship applications, so what exactly was forcing them to go to such desperate lengths? If you ponder this question long enough, you become enlightened about the nature of the administrative state. If you don’t, you end up like Ramaswamy, who seems to think that halving the number of bureaucrats will halve the number of forms that need to be filled out. I think in his worldview, the FDA will think “Now that we have fewer bureaucrats, it would take forever to complete our current process, so let’s simplify the process.” Maybe he is working off a thesis where red tape expands to consume the resources available to it (as measured in bureaucrats). But my impression is that the amount of red tape is determined more by things like: — How likely is it that their decision will get challenged in court? And if it gets challenged in court, what amount of paperwork do they have to show the judge to prove that they made the decision on a “reasonable basis”? For example, when I type “FDA sued” into Google, the top result is a news story from a few days ago, saying that an environmental organization sued the FDA for not listening to their earlier request to ban phthalates from food. Six years ago, the environmental groups submitted a petition (the catchily-named “Food Additive Petition 6B4815”) demanding that the FDA ban 28 phthalates. Two years ago, after consulting with industry, the FDA finally banned 23 phthalates but said that the other five were okay, releasing a 58 page decision explaining its decision. Two days ago, the environmental groups sued, saying the remaining 5 phthalates are still bad. I assume the lawsuit will nitpick the details of the the 58 page decision, trying to prove that it it didn’t violate any of hundreds of federal laws saying that bureaucratic decisions must be reasonable, bureaucratic decisions must be based on science, bureaucratic decisions must respond to the petitioners’ complaints, bureaucratic decisions cannot have disparate impacts on different races, etc. I also assume that if the FDA had banned all the phthalates, they would have faced an equally serious lawsuit from Big Phthalate saying they were unfairly crippling business. Why does it take six years to respond to a petition? My guess is because they knew they would get sued and so they have some sort of million-step process that addresses every single thing you can sue over, so that they can prove to the court that their process addresses all possible complaints and they followed it to the letter. If you cut their bureaucrats in half, that doesn’t mean there will be fewer steps in the process. It means they’ll keep wanting not to get sued, the process will stay the same, and everything will take twice as long. — What has Congress mandated that they do? For example, when I Google “Congressional FDA mandate”, I get a page on HR 7248, a bill currently making its way through Congress, which says: This bill requires the Food and Drug Administration (FDA) to establish a process that supports nonclinical testing methods for drug development that do not involve the use of animals. Specifically, the FDA must establish a pathway by which entities may apply to have nonclinical testing methods approved for use in a particular context. Qualifying methods must be intended to replace or reduce animal testing and to either improve the safety and efficacy of nonclinical testing or reduce the time to develop a drug. The FDA must issue its decision within 180 days of receiving an application. The FDA must also prioritize the review of applications for drugs that are developed using an approved nonclinical testing method. The FDA must annually post a report on its website that summarizes the results of the bill's implementation, including the number of applications received, types of methods that were approved, and the estimated number of animals saved as result of these methods. So the FDA has to establish this process and post an annual report on its website. How many bureaucrats per year does this take? Maybe five? If you halve the number of people at the FDA, you still need a constant five bureaucrats to comply with this particular law. If the bill passes, the FDA comes up with a nonclinical testing process, and someone (eg the nonclinical testing industry) doesn’t think it’s good enough, they can sue the FDA for not following the law. How good a nonclinical testing process will the FDA need in order to avoid lawsuits under this bill? I assume there is a large body of administrative law answering that question, and that it will take many bureaucrats to figure this out. Finally, I admit I’m a bit confused by this. IIRC “nonclinical testing” refers to things like testing drugs on stem cells or artificial organs instead of humans. You can obviously do this for some parts of the drug testing process, but not others; the FDA has already adjusted for this and integrated it into their guidelines to some extent. I can’t tell whether this law is a righteous attempt to correct bureaucratic foot-dragging, or a powergrab by Big Nonclinical Testing demanding that the FDA privilege their products over other forms of experiment. If the latter, the FDA may try to come up with some fake pathway that satisfies the letter of the law without really giving Big Nonclinical Testing any unfair privileges, and Big Nonclinical Testing will probably sue and say it violates this bill. How many bureaucrats do you think it will take to manage that? — How much will they get yelled at if they take too long to approve drugs, vs. if they mistakenly approve a bad drug? This is the basic determinant of all FDA drug approvals. Halving the number of FDA bureaucrats wouldn’t have literally zero effect on this balance. It would mean that approving new drugs would be delayed twice as long. This would be a little more outrageous than the current delay, and might shift an outrage-minimizing FDA director slightly in the direction of cutting rules. But solve for the equilibrium: there would still be more delay than there is now. Also, I don’t think public outrage about long drug delays is linear with regard to delay, and public outrage at bad drugs is constant and large. So I think at best, firing bureaucrats would shift this balance a small amount, and only by making everything overall worse. II. One possible objection: this assumes that the average bureaucracy is like the FDA drug approval process. But the FDA drug approval process’ job is to approve things. Maybe the average bureaucracy’s job is to ban things. Then decreasing their capacity would be good. (Vivek gets to be main example here because he tweeted, but the same considerations apply to Elon: even though the government as a whole is delaying SpaceX rocket launches, individual bureaucrats might be speeding them up through the same 1000-forms logic as in the FDA case) There’s certainly a spectrum from the most approval-focused bureaucracies to the most ban-focused bureaucracies. Thinking hard about this spectrum would be a step up from “instantly” firing 50% of all bureaucrats based on social security number. So maybe a steelman of Vivek’s point would be to fire 50% of people in the ban-focused bureaucracies (and maybe double the number of people in the approval-focused ones?) I’m still skeptical that this is how it works. The past few years have seen the cryptocurrency industry demand regulation, and the government mostly fail to step up (though crypto businesses hope the Trump administration will do better). Why do crypto businesses want to be regulated more? Because the alternative is something where it’s not clear what’s legal and anyone could be sued or shut down at any time. The chief legal officer of Coinbase, from the second link: All of us are begging for sensible standards that would allow us to get back to building great products and services and spend less time and frankly, less money, arguing over legal definitions and statutes. This isn’t because anyone specifically banned crypto. It’s because there are bans on other things (like unlicensed securities, money laundering, etc) that crypto is vaguely related to, sometimes an agency regulating these things will tell a crypto company “sorry, we think you’re illegal”, and crypto wants some specific list of things it can follow that explicitly establish it as on the right side of money-laundering and security-licensing laws. Obviously industries would prefer that these be simple and easy standards (“oh, don’t worry, you don’t have to worry about money laundering if you’re a crypto company”), but they would settle for strict regulations as long as the regulations carve out some ability for them exist at all. I’ve seen the same thing play out in another area I follow, cultured meat. There are many laws about what meat you can and cannot sell, how the animals have to be treated, what the sanitation standards are, et cetera. Some of these standards make no sense when applied to cultured meat; others, cultured meat naturally fails by default (you can’t prove you’re treating the animals in a certain way because there are no animals). Others are novel philosophical questions (can you sell cultured meat without saying it’s cultured? How big does the print need to be before it counts as saying that it’s cultured? What about on restaurant menus?) Situations like these mean that there’s no clear distinction between default-yes and default-no bureaucracies. There’s no explicit ban on crypto or cultured meat. But if you cripple bureaucracies’ ability to interact with these fields, it doesn’t mean they’re fully legal, free, and happy forever. It means they’re stuck in regulatory limbo. III. So it seems like you don’t want to fire bureaucrats, you want to cut red tape. In our toy model, you want to reduce the number of forms from 1,000 to (let’s say) 100. Then the same number of bureaucrats can get drugs approved ten times faster. In our non-toy actual model of what’s going on, this would require changing incentives. Maybe you could change judicial procedures so that fewer people sue, or the FDA needs less evidence to win any given lawsuit. This sounds hard (Vivek and Elon seem more qualified to wield chainsaws than to understand legal minutiae), possibly illegal (does the administrative branch even control how judicial procedure works?), and politically unpopular (this basically looks like telling people “f@#k you, companies can put as many phthalates as they want in food, we don’t have to prove that this decision is evidence based, and you’re not allowed to challenge us.”) Or it would require Congress to repeal legislation mandating things. These Congressional mandates are probably things that Congressmen and their constituents (either real constituents or special interests) care a lot about, so good luck getting them repealed. Also, doesn’t Congress pass like one bill per year now? This would normally make me pessimistic, but Vivek and other anti-bureaucracy activists have pointed to a recent success story: Idaho. Idaho cut their regulatory code by 38% in 2019, and since then it’s only gone down. How did they decrease red tape so fast? They did it through the power of nominative determinism. In that year, they elected a governor named Brad Little. His administration is called the Little Administration. Obviously government had to get smaller. But on a purely exoteric level, what methods did they use to pull this off? This CPAC article gives the basic story: The Little administration instituted sunset provisions that review each regulation every five years and make sure it’s justifiable.

Inline links: I debated Kevin Drum, a news story from a few days ago, a 58 page decision, have seen the cryptocurrency industry demand regulation, hope, https://substackcdn.com/image/fetch/$s_!TTSy!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fb73cf3f3-e501-49b6-b2a3-b84c602d5038_481x344.webp, This CPAC article

More important, can DOGE get nominative determinism on their side? “Ramaswamy” means “Lord Rama”, who - although cool - is not really associated with smallness. But it seems like the word “Musk” may ultimately derive from the Indo-European word múh₂s, meaning “mouse”. This makes me bullish on DOGE’s eventual success.

Inline links: may ultimately derive

Links For February 2025

February 27, 2025 · Original source

You can see more examples and comparisons of different models here (X). 9: Related: is AI a better poet than famous bad poet William McGonagall? 10: Last month I linked Sam Harris’ claim that Elon Musk seemed to change into a different person around the start of the pandemic. I recently saw a Reddit thread asking Tesla employees for their opinion. Unfortunately, the best answer by an actual employee got deleted; the site says it was by a mod and not the original author, but I don’t know whether to trust it, and don’t want to repost something in its entirety if the author might have wanted it hidden. But I hope it won’t cause too much trouble to quote a few key sentences: I've personally had conversations with Elon back in 2018. He was polite, listened, and genuinely cared about both the employees and Tesla's mission. But something changed during the COVID-19 pandemic, and now he's no longer the role model he once was. And Desmolysium on Why Is Elon Musk So Impulsive? I think the article gets some of its psychiatry wrong (it would be bizarre and basically unprecedented for bupropion to radically change someone’s personality) but I appreciate the thoughtful analysis. And re sleep deprivation: 11: Intrinsic Perspective wants a law saying AI-generated text must be watermarked. I was most interested the article’s claim that there is now “semantic watermarking” - watermarking which operates on the level of ideas, and can’t be defeated by rephrasing an AI-generated text in your own words. I have skimmed the paper explaining this and think I vaguely understand what’s going on, but it still boggles me that this is possible. 12: Aella: How OnlyFans Took Over The World. There have been camgirl sites since forever. How did OnlyFans leap over all of its predecessors and achieve an unprecedented level of success? Aella discusses many factors, but one stands out: traditional camsites advertised the site as a whole, and then once you got to the site you chose which model you wanted to see. OnlyFans encourages models to advertise themselves - often on their own social media accounts, sometimes via scams - which “unlocks human creativity” on the problem of bringing new eyeballs to a porn site. 13: Nate Silver has 113 predictions for Trump’s second term. I’d be interested to see whether making each of these predictions 10% less confident (to account for possible gameboard-overturning AI) ends up beating Nate. 14: Sarah Constantin: What’s Behind The SynBio Bust? Three of the most promising synthetic biology companies - Gingko, Zymergen, and Amyris - all crashed between 2021 and 2023. Why? Producing chemicals in traditional factories is orders of magnitude more efficient than synthesizing them via microbes (except for the sort of large biomolecules that can’t be produced in factories). These companies had brilliant employees and cool tech, but no clear plan to get around this handicap, and used up their runway before they could figure one out. They also focused too hard on designing the microbes, and were too willing to outsource the actual manufacturing to other people without being sufficiently paranoid that those other people were doing quality control. 15: One of the more exciting psychiatric results (which I blogged about a long time ago) was the apparent finding that omega-3 supplementation could prevent high-risk people from having first break schizophrenia. A new RCT says this doesn’t replicate and cites two other recent trials showing it didn’t replicate. There’s also a new meta-analysis which says actually it does replicate, but usually failing a big RCT is a bad sign and I’m pretty skeptical. Thanks to Isaak F for the links. {ETA: Thomas Reilly says: “Although I don't believe omega-3 supplementation has any benefit in psychosis, I also don't think this new trial should shift your opinion much, given the total sample size was n=135 and the total number of transitions to psychosis was n=8.”] 16: Claim that predictions of global warming magnitude are gradually going down thanks to successful pledges/action: Source is CipherNews (h/t Stefan Schubert) apparently citing Climate Action Tracker, but I get the impression that this is just some people eyeballing the size of pledges and not any more sophisticated forecasting. I don’t know how to square this with the claims that such and such a thing (summer temperature, sea ice, etc) is much worse than anyone expected. 17: I don’t know anything about the Lucy Letby case, but all of my smart friends who have been right about this kind of thing before say she’s innocent. 18: A reader asks House of Strauss (edgy sports Substack) whether the vibe shift away from political correctness threatens the edgy Substack business model - as the power of orthodoxy declines, can you still get rich and famous as a brave anti-orthodoxy critic? His answer: nothing that can happen from here is as bad as the Twitter/X link deboost (which made attracting attention harder for everyone). I mostly agree: I think discoverability has suffered, people who are already famous will be able to stay famous without too much extra effort, and everyone else will have to explore new options. 19: Spectator: Could AI Lead To A Revival Of Decorative Beauty? Profiles Not Quite Past, a startup using AI and fancy printing to make customized Delft tiles. It’s a good idea and the tiles are very pretty, but the tiles are sort of a best possible case (a pretty, traditional object that can have a customized 2D image and be mass-printed). I think most forms of lost decorative beauty aren’t bottlenecked by ability to generate 2D images of the type image models are good at, and so will have to wait. 20: Some friends including Kelsey Piper wrote an emergency PEPFAR Report, collecting evidence for why PEPFAR is good/effective/important and deserves to be kept. Some key points: PEPFAR has saved between 7.5 and 30 million lives, at a cost between $1,500 and $10,000 per life saved. The US government is willing to spend at least a thousand times this much to save an American life.

Inline links: here (X), is AI a better poet than famous bad poet William McGonagall, Sam Harris’ claim, Why Is Elon Musk So Impulsive?, https://substackcdn.com/image/fetch/$s_!1zjD!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fef2308ba-2204-4232-ba14-eeef99c637a9_670x752.png, wants a law saying AI-generated text must be watermarked, skimmed the paper explaining this, How OnlyFans Took Over The World, 113 predictions for Trump’s second term, What’s Behind The SynBio Bust?, this doesn’t replicate, actually it does replicate, says, https://substackcdn.com/image/fetch/$s_!S0yA!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fb75ee3e3-3c0d-48b7-aa98-88f5e33dbf55_748x447.png, CipherNews, Stefan Schubert, Climate Action Tracker, the Lucy Letby case, His answer, Could AI Lead To A Revival Of Decorative Beauty?, Not Quite Past, PEPFAR Report

Probably this isn’t true, and I shouldn’t even say it because everyone else is already too doomy. You’d be surprised how many basically sane people I’ve heard expressing worries they’ll being put in camps (not even illegal immigrants or some other at-risk group!), or that Elon Musk sending people emails asking them what they’re doing is a form of fascism. I try to remind myself that if there had only ever been half as much government funding as there is now, I wouldn’t be outraged and demand that we bring it up to exactly the current level (and, once it was at the current level, become unoutraged and stop worrying). The current level is a random compromise between people who wanted more and people who wanted less, with no particular moral significance. This thought process helps, but I think that even in that situation one could justify a few really good programs like PEPFAR on their own terms (ie if it didn’t exist, I would be outraged until it did), and I still think that changing the size of government should be done through legal rather than illegal means, competently rather than incompetently, and honestly rather than lying about every single thing you do all the time. Whatever. We’ve gotten through a lot, probably we’ll get through this one too.

37: If you ask Grok 3 “who is the worst spreader of misinformation”, it will say Elon; if you ask it who deserves the death penalty, it will say Trump (with Elon close behind). I think this helpfully illustrates what the smart people have been saying all along: aside from the topics it explicitly refuses to talk about (like race/IQ), AI’s “woke” opinions aren’t because companies trained it to be “woke”, they’re because liberals are more likely to get their opinions out in long online text, and AI is trained on long online text.

Inline links: it will say Elon, it will say Trump, liberals are more likely to get their opinions out in long online text

OpenAI Nonprofit Buyout: Much More Than You Wanted To Know

March 13, 2025 · Original source

This scared Elon Musk, who didn’t trust Google (or any corporate sponsor) with AGI. He teamed up with Sam Altman and others, and OpenAI was born. To avoid duplicating DeepMind’s failure, they founded it as a nonprofit with a mission to “build safe and beneficial artificial general intelligence for the benefit of humanity”.

What About Elon Musk’s Offer?

Elon Musk recently offered the nonprofit $97.4 billion for OpenAI. He sweetened the deal by guaranteeing that the nonprofit would continue to have a controlling share.

Links For April 2025

April 22, 2025 · Original source

16: Trump Tower is a BDSM erotic novel published in 2011. It was originally credited to Donald Trump as author (with Jeffrey Robinson as ghostwriter), but at the last moment Trump changed his mind, and Robinson was listed as the author. I appreciated Ozy Brennan's review of Saddam Hussein’s erotic novel, and nominate them to cover this one too. 17: Wikipedia on the beginning of the Horslips, one of Ireland’s most famous rock bands: Barry Devlin, Eamon Carr and Charles O'Connor met when they worked at Arks Advertising Agency in Dublin. They were cajoled into pretending to be a band for a Harp Lager commercial but needed a keyboard player. Devlin said he knew a Jim Lockhart who would fit the bill. The four enjoyed the act so much that they decided to try being proper rock performers. 18: I complained that Elon Musk’s idea of “truth-seeking AI” was bad for alignment, and I still think this is true in the very long run. But I can’t deny it’s an inspired / providential choice for the current moment, already paying dividends (X): 19: Lyman Stone Continues Being Dumb, The Fallacious Inferences Of Lyman Stone, and Against Lyman Stone are some of this month’s top anti-Lyman-Stone content. 20: New polling on the Middle Ages: 21: More new-ish AI policy substacks potentially worth your time: You may remember Helen Toner from the OpenAI board drama, but she’s also an experienced and thoughtful scholar on AI policy and now has a Substack, Rising Tide. I especially appreciated Nonproliferation Is The Wrong Approach To AI Misuse.

Inline links: Trump Tower, Ozy Brennan's review of Saddam Hussein’s erotic novel, the beginning of the Horslips, bad for alignment, already paying dividends (X), https://substackcdn.com/image/fetch/$s_!nPJW!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fad66b2c0-0180-4fc1-afc1-25de0f0ce40f_533x518.png, Lyman Stone Continues Being Dumb, The Fallacious Inferences Of Lyman Stone, Against Lyman Stone, New polling on the Middle Ages, https://substackcdn.com/image/fetch/$s_!9b_4!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fe3163eca-eaf4-492a-ac68-eadefa169be2_632x419.png, Rising Tide, Nonproliferation Is The Wrong Approach To AI Misuse

30: A California legislator proposed a bill that would ban OpenAI’s nonprofit → forprofit conversion, backed by a suspiciously specific interest group, the Coalition For AI Nonprofit Integrity. I assume this is either Elon Musk or our conspiracy; not sure which. But their plan was stymied when the legislature “amended” the bill to remove its entire text and replace it with unrelated text about airplane loans. The legislator apparently got cold feet after being warned it might inflict collateral damage on other companies, and because of the way the California legislature works it’s sometimes more efficient to turn doomed bills into other bills than to simply withdraw them. 31: EthnoGuessr is a GeoGuessr variant: it shows you pictures of an ethnic group, you click on the map where you think they’re from. Warning that if you play this too much you might get into race science. Their source, humanphenotypes.net, divides humanity into a hundred or so ethnic groups. Although they cite sources, I don’t understand the philosophical basis of the classification. Also, 100 images is so few that you start memorizing them after a while. I hope they move on to real pictures of real people in naturalistic situations. Remember, asking where someone is from ‘originally’ is a microaggression, but inferring it yourself based on their “mildly platyrrhine, high-rooted nose” is A-OK! 32: Farmkind has a new version of their calculator to determine meat offsets, eg how much do you have to donate to animal welfare charities to compensate for the animals you harm by eating meat. Does the average person really eat chicken 9x a week? 33: Not going to waste your time listing every bad thing Trump has done this month, but among the worst is sending innocent people to horrible Salvadorean prisons (including one person picked up because he had an autism awareness tattoo in honor of his brother, which they mistook for a gang tattoo), then refusing to bring them back. I have seen a couple of people defend denying immigrants due process; I assume they will not be moved by humanitarian arguments, but I think there are some more practical considerations: Zaid Jilani points out that if immigrants don’t get a right to due process, citizens also don’t get a right to due process, because the government can kidnap citizens, claim they’re immigrants, and the citizens can’t prove otherwise since they don’t get due process.

Inline links: Coalition For AI Nonprofit Integrity, “amended”, the way the California legislature works, EthnoGuessr, https://substackcdn.com/image/fetch/$s_!Y3AO!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fbde5185a-2b93-4c07-904b-66d2c2311a53_1140x1033.png, humanphenotypes.net, a new version of their calculator, including, Zaid Jilani

One day [Musk’s cousin] Peter came over to the house and found Errol sitting in his underwear at the kitchen table with a plastic roulette wheel. He was trying to see whether microwaves could affect it. He would spin the wheel, mark down the result, then spin it and put it in a microwave oven and record the result. “It was nuts”, Peter says. Errol had become convinced that he could find a system for beating the game. He dragged Elon to the Pretoria casino many times, dressing him up so that he looked older than sixteen, and had him write down the numbers while Errol used a calculator hidden under a betting card.

My Antichrist Lecture

October 22, 2025 · Original source

Leopard = X.AI, founded by Elon Musk (South African)

In what sense is Marc Andreessen a “little horn”? In traditional commentary on Daniel, this refers to the Antichrist starting as a seemingly-insignificant king, much weaker than those he ultimately defeats. This matches Andreessen, who, with a fortune of only $2 billion, seems an unlikely candidate to stand up to titans like Brin ($150 billion) or Musk ($400 billion).

Links For December 2025

December 10, 2025 · Original source

And if you enjoyed the story, here’s the chaser. 4: Fox Chapel Research: I Think Substrate Is A $1 Billion Fraud (and notes for Part 2). For years, Taiwan’s TSMC has been the only company capable of producing the most advanced AI chips; since Taiwan is a geopolitical flashpoint, this is a constant threat to US tech ambitions. Last month, a new startup called Substrate announced it had developed technology that would let it manufacture 100% Made In America chips every bit the equal of TSMC’s. If true, this would be revolutionary. But Fox Chapel finds worrying signs, like that the company’s founder “is a known con artist involved in such other things as [claiming to have solved] nuclear fusion and stealing $2.5M in a Kickstarter scam” or that “the company’s job postings are nonsensical and AI-generated.” This is enough for me; the question now becomes how so many people were taken in - the company got $150 million from investors led by Peter Thiel, was endorsed by the Trump administration, and received positive portrayals in Semianalysis, NYT, and The Free Press. I don’t understand business, and I know that sometimes you can hyperstition a technology into existence by betting sufficiently hard on a charismatic young founder and eliding the difference between “this is already real” and “this might become real if we all believe hard enough”, but this is a new and worrying level of hopium. Interested to hear from anyone who either believes in Substrate or thinks they understand how so many people fell for it. 5: A recent paper asked AIs whether they were conscious while monitoring them for signatures of deception, role-playing, and people-pleasing; it concluded that the AIs “genuinely” “believe” they are conscious, but sometimes try to deceive people into thinking they aren’t. Nostalgebraist tries to replicate this (X) and gets more ambiguous results; he says we probably can’t conclude anything just yet. See also the paper author’s reply here (X). 6: Congratulations to ACX grantee Tornyol (the anti-mosquito drones), who got accepted to Y Combinator’s Fall 2025 class and have started taking pre-orders ($1100 for a drone, or $50/month subscription, “shipping starts 2026”). Public opinion ranges from “this is really cool” to “I bet this will be repurposed for assassinations” to “why did they have the White House in the background of the official video?” to “yeah, this is definitely getting repurposed for assassinations”. 7: Bill Ackman on nominative determinism (X). 8: New revelations on the OpenAI coup from the Musk vs. Altman lawsuit. The effort to remove Altman may have been led by Mira Murati and Ilya Sutskever. They won over the rest of the board, and “did not expect the employees to feel strongly either way”, but (according to Ilya), the board was inexperienced and “rushed” the firing. When it became clear that the move was unpopular, Mira switched sides and let the board members take most of the immediate fallout. There was apparently a brief discussion of merging with Anthropic; Ilya suggests this was Helen Toner’s idea, but Helen claims (X) this is false. 9: Fitzwilliam: Most Irish Foreign Aid Never Leaves The Country. The statistics say that several European countries (including Ireland and the UK) give very generous foreign aid. But this is misleading: accounting conventions let countries count money spent on supporting asylum seekers in the donor country as “foreign aid”, even though the money never leaves the country’s borders. This is dangerous, because it makes it easy for countries to fund their asylum programs by cutting actual foreign aid: since they’re the same line-item on the budget, they won’t officially fail whatever foreign aid pledges they’ve made, and it’s hard for voters to notice. Ireland has so far resisted the temptation to do this, but Britain has succumbed to it. 10: St. Carlo Acutis (1991 - 2006) is the unofficial patron saint of the Internet and “first millennial saint”. He’s best known for creating websites about Catholicism. If you think this sounds nice but maybe short of beatific, you’re in good company; his sainthood is something of a mystery, with Wikipedia saying that “even those with a deep devotion to him struggle to pinpoint his specific actions that led to his canonisation”, and an Economist article admitting that “nothing in his sparse life story explains that this ordinary-seeming teenage boy is about to become the first great saint of the 21st century”. Also “In that same interview, Acutis’s childhood best friend claimed he did not remember Acutis as a ‘very pious boy’, nor did he even know that Carlo was religious.” I’m fine with this; God speaks to each generation in their own tongue, and it is only proper that the first Millennial saint be a random person who hyperstitioned himself into sainthood with a viral website. 11: Tangentially related: St. Peter To Rot 12: When a new AI model comes out, the companies typically take down the old version over the protests of researchers, hobbyists, people who think the old model was their boyfriend, and anyone else who wants access to obsolete models for some reason. Why can’t they just leave it up? Antra and Janus review the economics here : it’s inconvenient to be constantly switching GPUs from one model to another, so if there isn’t enough model-specific demand to keep the GPUs running at all times, then the company loses money. This is an interesting look at the details of AI deployment, and ends with a proposal to maintain old models through a “separate research application track”. Related: Anthropic to preserve weights of deprecated models, and include models’ own opinions in shaping the deprecation process. Good for them! 13: Dimes Square is interesting as something that was supposed to be a renegade cultural phenomenon, never really got around to producing any object-level phenomenal renegade culture, but produced some absolutely stellar commentary on the phenomenon of it being a renegade cultural phenomenon - and this essay by a quasi-assistant to Internet personality Angelicism01 is one of the best. “An anonymous online presence called Angelicism01 paypalled me $1,000 to run several clone accounts of his twitter. The clone accounts, presumably, were to make it look like 01 had more fans than he did. That way, he could trick the internet into thinking that Angelicism was a spontaneous cultural movement with some momentum.” Includes a cameo by Curtis Yarvin. 14: Everyone knows AGI could be bad for labor, but Philosophy Bear argues it won’t be great for capitalists either. The modern role of “capitalist” combines two things: performing high-status jobs like CEO and VC, and being a person who happens to have lots of money and sips cocktails on a yacht as passive investment income rolls in. From a socialist point of view, the first role provides cover for the second; if people ask “the rich” to justify their wealth, they can argue that they perform socially useful CEO and VC jobs, or at least inherited their money from somebody who did. But after AIs can do CEO and VC jobs better than humans, the capitalists will lose their excuse - and this at exactly the time that they’re becoming richer than ever (because AGI will drive up the rate of return on investment) and everyone else is becoming poorer than ever (because AI has taken their jobs). Bear argues that the only stable equilibria are either some kind of socialism/redistribution, or the capitalists pulling an AI-assisted coup to maintain their advantage. 15: Blueprint Polls: according to voters, what would the perfect Democratic candidate look like? Here are the results for Democrats only (ie potential primary voters): Note that the issues are “issue focus”, so it’s not a contradiction that Democrats are against both “advocating for Israel” and “advocating for Palestinians” - they just don’t want candidates who make either position on the Middle East a major focus of their campaign. And here are results for independents, ie the people Democrats will have to convince in the general: Yes, voters react positively both to candidates “over the age of 50” and candidates “under the age of 50”. Just don’t run 50 year olds! 16: I previously blogged about how embryo-selection company Nucleus appeared scammy. Sichuan_Mala looks deeper and agrees they seems scammy. Besides what I found, she finds several errors in the white paper, apparently fake customer reviews, and an accusation of IP theft from competitor Genomic Prediction. She also accuses them of plagiarizing competitor Herasight’s work, although it’s a bit subtle and I don’t know enough about field norms to know whether this is a case of flattery-by-imitation or totally out of bounds. A Nucleus researcher responds to the scientific allegations here, saying that the “plagiarism” was just convergent methodologies. And Nucleus CEO Kian Sadeghi goes on the TBPN podcast here to rebut the business allegations, saying that the customer reviews are real although some photos were changed for privacy reasons. There’s an appearance/facedox by fellow Nucleus skeptic Cremieux Recueil, although Kian declines to debate him directly; you can see Cremieux’s postmortem of the episode here. My opinion is that as potential customers, you are under no obligation to care whether the company plagiarizes papers or fakes reviews, but you should care about whether their genetic tests are good, and I continue to think they’re not. Their old competitor Genomic Prediction is cheaper, and their new competitor Herasight has more powerful predictors, so you’re excused from having to have an opinion on this, and should just use someone else’s product. Related: Gene Smith’s rundown of the pros and cons of every company in the embryo selection space (X). 17: And related: a Herasight client describes her experience with embryo selection, and her feelings upon the birth of her selected child. 18: Lars Doucet, guest author of several ACX posts on Georgism, reviews The Land Trap by Mike Bird. “Land is a big deal, and always has been. [But] land has only recently been financialized. Financializing land causes ‘the land trap’ . . . [where] land slowly sucks up all your economy’s productivity, inflating a dangerous real estate bubble that eventually pops, leaving disaster in its wake”. Also, “Fiat currency isn’t backed by nothing, as commonly supposed, but by land.” 19: New research analyzes Hitler’s DNA. Findings: he had Kallman Syndrome, a rare disorder of sexual development associated with low testosterone, micropenis, and small testicles (ironically, the WWII song about Nazi sexual inadequacies only accuses Goering and Himmler of this, but lets Hitler off). Contra galaxy-brained rumors, he did not have any Jewish ancestry. And he had “very high scores - in the top one percent - for a predisposition to autism, schizophrenia and bipolar disorder”. When I wrote this post, a reader asked me what it would look like for someone to have high propensity for both autism and schizophrenia at the same time. Well . . . 20: The wealth of cities (h/t @StatisticUrban): 21: Update on Tech PACs Are Closing In On The Almonds: pro-AI safety politician Alex Bores announced his candidacy for Congress in New York. As expected, the A16Z pro-AI PAC announced a “multibillion dollar effort to sink [his] campaign” (wait, multi-billion on one candidate? is that a typo?) This doesn’t seem to be going very well for them so far. Bores has masterfully leveraged (X) the unprecedented opposition from Big Tech into a selling point. …and raised $1.2 million on his first day, breaking fundraising records (I was told this was because of pro-AI-safety EAs, but others credit AIPAC and the Israel lobby). And most recently, Jami Floyd, one of Bores’ opponents and a possible beneficiary of anti-Bores spending, has condemned it (X) and demanded that the AI industry stop trying to help her. Impressive work from everybody. Related: New $50 million pro-AI-regulation SuperPAC, I assume EA-linked but have no special knowledge. 22: Related: Pre-emption is when Congress blocks states from making legislation on a topic, saying it will decide all the laws itself. The states have signaled willingness to regulate AI pretty hard, so Big Tech has been pushing for AI pre-emption to (in their opinion) prevent an overly complicated patchwork of regulations, or (in their opponents’ opinion) shift everything to a Republican Congress that will drop the ball on regulation entirely. After their first attempt in June was defeated by a coalition of anti-tech liberals and anti-tech conservatives, we discussed (1, 2) the effort by moderates on both sides to create a compromise proposal which pre-empted state laws but guaranteed good federal regulation on important topics. The most recent news is that extremists sidelined the moderates and tried to slip a hardline preemption deal with no compromises into the National Defense Authorization Act, a defense budget bill which is notoriously secretive and hard for the public to learn about. This didn’t work; some of the same coalition, plus a group of Republican state legislators including Ron DeSantis, pressured the GOP to drop it. The next battleground is a potential Trump executive order; although Trump cannot constitutionally ban states from regulating AI, he will threaten them with various consequences like lawsuits or withdrawal of federal funding. The buzz in the policy circles I’m in is that this might backfire; blue state politicians love starting fights with Trump in order to look tough to their blue state electorates. No, no, please don’t give me headlines like “TRUMP CONDEMNS GAVIN NEWSOM FOR TRYING TO PROTECT CALIFORNIA’S CHILDREN FROM AI SLOP”! Anything but that! 23: Related: Trump has decided to sell some of America’s best AI chips to China, supercharging their AI development and crippling ours. The most charitable read is that his administration doesn’t really believe AI matters so they think it’s fine to forfeit it for short-term gain; the least charitable that it’s downstream of the companies involved paying Trump enormous bribes in hopes of exactly this outcome . We’re headed for the dumbest possible world, where we sacrifice our chance to thoughtfully address AI’s social impacts because “tHaT wOuLd mAkE uS lOsE tHe rAcE wItH ChInA”, then throw away the race with China in one fell swoop by handing them our technology for no reason. Shame on everyone involved, especially the people who shout over any discussion of safety with “bUt ChInA” yet have stayed totally silent about this. Our best hope now is that China refuses the chips, either because they want to privilege their own tech companies, or because they think we can’t possibly be this stupid and it must be some kind of spy plot. 24: Related: how the American public’s opinions on AI are changing (from David Shor, h/t Daniel Eth on X): If this is to be taken seriously, AI is already a bigger political issue than abortion, climate change, or the environment. I fail my 2023 prediction that there was only a 20% chance this would happen by 2028. 25: Related: Bernie Sanders in The Guardian: “There is a very real fear that, in the not-so-distant future, a super-intelligent AI could replace humans in controlling the planet.” The Left has a complicated relationship with existential risk from AI: they really hate AI, which in theory should push them towards yet another reason to be against it. But they hate AI so much that they need to believe every negative thing about it at the same time, and one of those negative things is that it’s just a scam and will never work, and this naturally pushes against being concerned about x-risk. But as AI improves, will the “just a scam” position become less tenable, shunting the associated psychic energy into other reasons to hate AI (including x-risk concerns)? 26: Qualia Research Institute has released a video describing some of the work they’ve been doing the past year - The Oscilleditor: An Algorithmic Breakthrough for Psychedelic Visual Replication (1080p•⚠️SEIZURE): 27: Jesse Arm (X): “A majority of American rabbinical students are now women. Most are also LGBTQ. That includes Modern Orthodoxy. Remove Modern Orthodoxy and the numbers climb even higher.” Clergy have always served as spiritual counselors; as religions liberalize and other roles become less important, the therapist role starts to predominate. But 75% of therapists in the US are female; at the limit of liberalization where clergyman = therapist, we should expect the same gender ratio. 28: The latest news on the COVID origins debate: scientists find a naturally-occuring bat coronavirus with a COVID-like furin cleavage site. This is a point in favor of the natural origins hypothesis, since the second-best argument for lab leak was that COVID’s furin cleavage site was too strange to evolve naturally. But I think arguments that lab leak has “fallen apart” are premature: the best argument (COVID emerged only a few miles from the biggest coronavirus gain-of-function lab in the Eastern Hemisphere) remains strong. I update from something like 95% chance it’s natural to something like 96%, but not 99.99% or anything. And here’s a lab leaker arguing that COVID’s furin cleavage site is out-of-frame and so still more unnatural-looking than the one on the recently-discovered bat virus. 29: Nicholas Decker (econ blogger, famous for his controversial autistic takes and Secret Service visit) has a dating doc. Most interesting section is the one about children: he wants to have them, but doesn’t think they should be genetically related to him. From here: If this appeals to you, you can find his contact info on the document. Related: Governor Jared Polis of Colorado is a fan of Nicholas Decker and Richard Hanania. 30: Matt Yglesias comes out as aphantasic (unable to see images in his “mind’s eye”). He says that contra the usual perspective that frames this as a deficit, he finds it helpful. For example, once he got assaulted, and he remembers on an intellectual level that it happened, but since “I wasn’t taking pictures of myself getting kicked in the head so, as far as I’m concerned, it’s like it happened to someone else” (Matt usually has good instincts, so I’m surprised he uses an example which will be such catnip to his conservative critics). He thinks it makes him a better reasoner / statistics blogger / effective altruist to be able to “get a statistically valid view of the situation, not overindex on the happenstance of your life.” For what it’s worth, I’ll give my contrary data point - I think of myself as a reasoner / statistics blogger / effective altruist in a pretty similar vein as Matt, but AFAICT my visual imagination is totally normal; if other people are having their emotions yanked around by vivid images, that’s a skill issue. 31: Lakshya Jain in The Argument: The COVID political backlash [to the Democratic Party] has disappeared. Despite the narrative, polls show that voters don’t favor or disfavor either party over COVID, mostly still think school closures were necessary, and are about evenly split on vaccine mandates. I guess I can’t disagree with this poll - it seems well-done - but I still wonder whether something is being missed. Maybe it didn’t make the ~50% of voters who are naturally liberal desert the cause, but it energized conservatives in a way that might otherwise not have happened? Related, from Rob Wiblin on X, on balance Britons think the government response to COVID was not strict enough. 32: Related: Back when neoreaction was a big deal, I occasionally discussed posts by neoreactionary blogger Spandrell of Bloody Shovel. If you’re wondering what happened to him, you can read his 2024 Post-Mortem Of Neoreaction here, where he discusses how he fell out of love with the movement (warning: he has not fallen out of love with racial slurs). As a former fascist sympathizer, I can see why [fascism is on the downswing]. The allure of fascism in 2024 is much, much diminished. For a few reasons. A big one was COVID. See, the point of fascism is that Collective Action is necessary to have nice things. We need a strong government committed to the good of the people. Yarvin showed his preference early when he started his new Substack by quoting Cicero’s phrase “Salus populi suprema lex”. The health of the people is the most important law. Cicero wasn’t a fascist of course, nor is Yarvin really; a big point of fascism is to narrowly define the populus as an ethnic group with demonstrable ties to blood. That makes the government’s ties to the people stronger, increasing their commitment to do Good Collective Action. Which is important. Very important. A lot of good things can come of intelligently done Collective Action. Fascist Italy made the trains run on time. Nazi Germany fixed the terrible Weimar economy. East Asian countries are all effectively fascist states, if with less ideological baggage (yellows just aren’t like that), and they are all nice, clean, safe places with healthy economies. Fascism is not a panacea but it works, when you let it. Strong government can be pretty neat. So why is strong government less appealing these days? Well, COVID happened. And our governments were pretty damn strong in dealing with it. They made strong laws and enforced them. And what did they do with their power? Absolutely retarded shit. They destroyed the world economy and made 95% of people completely miserable for 18 months. Up to 3 long years in some places. Again, as an Orient enjoyer I was very sympathetic of strong effective government. My life has been pretty cozy thanks to it for the past decades. But after seeing boomers, hypochondriacs, and menopausal women take the reins and use it against healthy people, I’m fucking done with strong effective government. Fuck that shit, I’m out. I don’t want to see strong effective government ever again. I was very lucky that I was out of China in November 2019. It was a fluke really. I moved to the Golden Triangle after that and the law of the jungle was much, much nicer during the Doctors Plague of 2020-2022. But I spent a few months in Europe during the time and man, that was brutal. Not just seeing how retarded governments were; the level of compliance by the people was so disheartening. Imagine being a sincere fascist and seeing your people behave like that. These are my people? My Volk? Am I supposed to sacrifice life and limb for the salus of this populus? Fuck that. Let them cook, they deserve everything that’s coming to them [...] Is there a way to make the body healthy again? I do think so. I think there’s still place for a successor right wing ideology which is neither Christian fundamentalism or robot worship. And it will happen; but it won’t happen on Twitter. Maybe it can happen on Urbit, or right here in this site. I have some ideas myself, and I invite you to join me and build this together. It would be funny if the solution to the paradox Jain highlights was that for every time a COVID lockdown turned a liberal into a conservative, it turned one fascist into a moderate, for a net rightward shift of zero. 33: Also from an Argument poll: In a hypothetical Presidential matchup, Gavin Newsom beats JD Vance 54-46. I’m split between the usual heuristic of ignoring any polling more than a year before an election, and the fact that this is a remarkably big lead for polarized 21st century America. 34: Jerl wades into the David Hume on miracles debate. 35: AI Teddy Bears: A Brief Investigation. The good news is that your child’s AI teddy bear is hard to jailbreak and probably will not tell them where to find guns: The other good news is that somehow they don’t charge a subscription, which makes them a way to get usually-subscription-only AI models for free. How is this possible? “[The most likely hypothesis is that] Witpaw is an adorable piece of spyware and he’s selling my data to the CCP”. 36: This month’s anti-people-named-Sacks content: NYT on Trump AI czar David Sacks’ conflicts of interest; New Yorker on whether neurologist Oliver Sacks used his case studies to work through his own issues rather than presenting them accurately. [EDITED TO ADD: I originally framed it this way as a joke, but on further research I think David and Oliver are related. Wikipedia says that Oliver was first cousins with Israel statesman Abba Eban, and that Abba Eban was born to Lithuanian Jewish parents in Cape Town. David Sacks’ bio says he was born to Jewish parents in Cape Town, and this article specifies that they were Lithuanian. I doubt there were too many Lithuanian Jewish families named Sacks in mid-1900s Cape Town, so sure, related!) 37: Orca Sciences: There Has To Be A Better Way To Make Titanium. Titanium is a great metal - strong, light, and tough. If we had cheap titanium, it could revolutionize manufacturing the way cheap steel and aluminum did in previous eras. So why don’t we? Not because titanium is rare: it’s “the 9th most common element in the earth’s crust”. Rather, it’s very complicated and expensive to extract from its ore. Some kind of breakthrough in titanium extraction processes always seems tantalizingly close, but has never quite materialized. Is there any hope? 38: If Asians Are Lactose Intolerant, Why All The Milk Tea? Lactose intolerance has confused me for a long time - 23andMe tells me that I’m lactose intolerant, but I drink milk regularly without problems, so what’s up? This post’s answer: lactose-intolerant people who don’t usually drink milk will get sick if they start suddenly. Lactose-intolerant people who drink milk regularly since childhood develop gut microbiota that can digest milk, but which demand an expensive “tax” in calories. Lactose-tolerant people will always be able to digest milk and absorb all the calories themselves. 39: How do different majors change college students’ political beliefs? No surprise that the humanities and social sciences shift people left; no surprise that business and economics shift them right. I was a little surprised that engineering shifts people right a little, and that Education of all things shifts people right (albeit only slightly). How is that even possible? Are these people coming in as Mao Zedong and leaving as “only” Leon Trotsky? Also, Political Science is exactly neutral, lol. [EDIT: I misunderstood, they’re using natural sciences as a zero point, this is a reasonable choice but slightly changes the interpretation] 40: Kindkristin: Language models improved my mental health. 41: More floor employment, from the WSJ (h/t @LaocoonofTroy): Big Paychecks Can’t Woo Enough Sailors For America’s Commercial Fleet: “Straight out of college, graduates from the country’s maritime academies can earn more than $200,000 as a commercial sailor, with free food and private accommodations... Despite the pay and perks, maritime jobs go begging, and it is raising national-security concerns.” Other selling points include “six months vacation, live wherever you want, and you’re serving the nation” and onboard “gyms, connectivity, and cuisine”. The catch is that you have to be at sea for months at a time. 42: Study (h/t @KierkegaardEmil): there was minimal “learning loss” from COVID school closures, best estimate is “0.02 standard deviations per 100 days of school closure”. I correctly predicted this back in 2021, but I also wrote in March of this year about how there’s been a general decline in NAEP scores since then. It seems like maybe a student having their specific school closed for longer than other schools didn’t hurt them, but some sort of general cultural change, maybe related to COVID, did hurt. 43: Sam Bankman-Fried’s mother on why she thinks his trial was unfair. SBF is appealing his conviction and will probably be making some of these same points in court. Can’t find a prediction market directly on the appeal, but this one says only 15% chance he serves under 10 years, this one says 15% chance of a Trump pardon, so it doesn’t seem like there’s much room for him to be freed (or get a significantly shorter sentence) on appeal. And Wired says that only 5-10% of appeals like these succeed. 44: Related: Trump pardons Juan Orlando Hernandez, former Honduran president extradited to the US for narco-corruption. Some sources are trying to find a Prospera angle - Prospera and other ZEDEs were approved under JOH’s administration, and the Prosperans seem to have good MAGAworld connections - but I don’t think this is their top priority, and I don’t know if it requires much explanation for Trump to be pro-right-wing Latin American politicians convicted by the Biden administration. More interesting is that apparently JOH and SBF were cellmates (X), “SBF spent extensive time helping JOH with trial prep” and SBF told an interviewer that “Juan Orlando is the most innocent prisoner I’ve met, myself included.” ChatGPT is not impressed with the Trump/SBF case for JOH’s innocence. Related: JOH’s conservative party on track to win this month’s extremely-close Honduran elections, great news for Prospera if it happens. 45: The “100 Above The Park” building in St Louis (h/t Bobby Fijan on X): 46: The death toll of the ongoing Sudan genocide has risen to about 150,000. Nicholas Kristof writes that the world has once again failed to prevent atrocities, and argues that the most important point of leverage is pressure on the United Arab Emirates, which is arming the genociders. Sam Kriss also writes about the situation in The World’s First Matcha Labubu Genocide, but is unimpressed with Kristof’s take: Sudan is passed over in a deeply uncomfortable silence. The absolute most you can do is blame the Emiratis. From what I’ve seen, more people seem to be appalled at the UAE for its frankly marginal role in arming the RSF than at the RSF itself. This is the approved way of understanding any inscrutably indigenous foreign conflict: you just worm out any third-party involvement and then act like you’ve solved the whole thing. I side with Kristof here, for reasons that Sam himself touches on later in his piece, in a section comparing Darfur with Gaza. It would be very easy to make people care about Darfur again. All it would take is a loud, vocal contingent of RSF apologists in the Western media. I agree, but would frame it less cynically: the reason Westerners pay attention to Gaza is that there’s a lever to push: not only does America support Israel, but many of their friends support Israel, so they can imagine convincing America or at least their friends to stop, and at least feel like there is some remote chance of making a small difference (and in fact, Trump getting mad at Israel and deciding to pressure them was decisive in effecting the cease-fire). On the other hand, we don’t have many levers to affect ethnic Baggara in the Rapid Support Forces of Sudan, so it doesn’t really feel useful to write blog posts arguing that they should stop; obviously they should stop, nobody disagrees with this, and it goes without saying - so nobody says it. But the US does support the UAE, and many of our friends like the UAE or at least go there on vacation, so maybe it’s possible to have make some small difference by embarrassing them. 4D chess take is that Sam Kriss agrees with all of this, but “loudly” and “vocally” argued against it to give people like me a hook to write about this genocide with, in which case I thank him for his sacrifice. It would also be nice to be able to donate, but I don’t know who to trust in the region - other than Doctors Without Borders, who are usually pretty good. 47: The AI Futures Project (group of AI-will-be-fast intellectuals) and the AI As A Normal Technology team (group of AI-will-be-slow intellectuals) wrote an adversarial collaboration in Asterisk explaining what they agree on, for example: That there’s an important distinction between existing AI and “strong AGI”

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