Shi Zhengli
Article
Shi Zhengli is a recurring person in the Astral Codex Ten archive, appearing 2 times across 2 issues between July 30, 2022 and April 09, 2024. The archive places it in contexts such as “published by Dr. Shi Zhengli’s team at the WIV”; “Everyone agrees with this, including Shi Zhengli”. It most often appears alongside BANAL-52, Canada, China.
Metadata
- Category: People
- Mention count: 2
- Issue count: 2
- First seen: July 30, 2022
- Last seen: April 09, 2024
Appears In
Related Pages
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- BANAL-52 (2 shared issues)
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- Canada (2 shared issues)
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- China (2 shared issues)
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- Chinese government (2 shared issues)
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- COVID-19 (2 shared issues)
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- furin cleavage site (2 shared issues)
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- Huanan seafood market (2 shared issues)
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- Jesse Bloom (2 shared issues)
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- Laos (2 shared issues)
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- MERS (2 shared issues)
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- NIH (2 shared issues)
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- Rootclaim (2 shared issues)
External Links
Source Context
Recovered passages from the original issue text. When the raw archive preserved outbound links inside the source passage, they are listed directly under the quote.
Image source: https://www.bloomberg.com/news/features/2020-12-30/china-is-making-it-harder-to-solve-the-mystery-of-how-covid-began If SARS-CoV-2 originated in an animal somewhere around the Yunnan / Laos area, how did it make it all the way to Wuhan without leaving a trail along the way? 4. The story of RaTG13 Although I enjoyed the book, I do have one pretty major criticism. The authors repeatedly make the claim that a virus called RaTG13, which was being studied at the WIV before the pandemic, is the closest known genetic match to SARS-CoV-2. But this claim is outdated and no longer correct. In September 2021 researchers identified a virus called BANAL-52 in Laos that’s a 96.8% match to SARS-CoV-2, closer than RaTG13’s 96.2% match. (Important note: a 96.8% match is still a long way off in genomic space, and does not imply that this is the same virus as SARS-CoV-2, or even necessarily a progenitor.) At first I thought maybe the authors didn’t mention BANAL-52 because it was discovered after the book was published, but this isn’t the case – Viral was published November 16, 2021, nearly two months after the discovery of BANAL-52 was published. Although I’m writing an overall-positive review here, I don’t want to go easy on the book where serious criticism is warranted. It’s completely unacceptable that BANAL-52 wasn’t mentioned. Even if it would have been inconvenient from a publishing standpoint, the authors should have rewritten the RaTG13 chapter, or at least included an addendum about the discovery of BANAL-52. With that being said, I think the story of RaTG13 is still interesting and important, so I’ll give a quick summary here. At the start of the pandemic in 2020, SARS-CoV-2 was quickly sequenced, and the full genome sequence was published by Dr. Shi Zhengli’s team at the WIV. In this paper, they also briefly mentioned that the genome was a 96.2% match with another bat coronavirus called RaTG13 – the closest known match at the time. Oddly, the mention of RaTG13 did not include any reference, footnote, or link to any previously published sequence. Although the WIV didn’t provide details on this mysterious RaTG13 virus, a group of internet volunteers, including both amateurs as well as professional scientists working in their free time, began to investigate. This loose collection of open-source researchers, called DRASTIC, uncovered a medical thesis describing an outbreak of a mysterious disease in 2012. Six men who had been working in a bat-infested mine in Mojiang County, China, fell ill and were admitted to a hospital with symptoms including dry coughs, shortness of breath, fevers, muscle aches, headaches, and fatigue. Three of the men eventually died of this mysterious illness. In the years following this incident, teams of researchers (including a team led by Dr. Shi Zhengli of the WIV) were sent to investigate the cause of this illness and collect samples from the Mojiang mine. This sampling led to the discovery of a novel SARS-like coronavirus in 2013, and a part of its genomic sequence was published under the name BtCoV/4991 in 2016. The DRASTIC researchers discovered that RaTG13 was genetically identical to the BtCoV/4991 sequence from the Mojiang mine – it was the same virus, and had just been renamed for some reason, without any public record of the change. They also discovered that at least eight other closely related coronaviruses were also sampled from this mine and brought to the WIV. Although unhelpful throughout the investigation, the WIV eventually verified these facts when pressed on them, and an addendum was added to the original paper confirming DRASTIC’s account of the origin of RaTG13. So what should we make of this? Well, as I mentioned before, RaTG13 is no longer the closest known genetic match to SARS-CoV-2, so maybe the whole story is less important as it pertains to the origin of the pandemic. But the discovery of BANAL-52 doesn’t really resolve things either [2]. Laos is very far away from Wuhan (actually even further than Yunnan), so we’re left with the same question as before – how did SARS-CoV-2 make it all the way to Wuhan from such a distant natural reservoir without leaving a trail along the way? 5. Lack of institutional transparency and competence A lot of the book is devoted to criticizing the Chinese government’s lack of transparency during the pandemic. Some brief examples: In the early days of the initial outbreak in Wuhan, hundreds of people were investigated and punished for the crime of “spreading rumors”. This included whistleblowing doctors who attempted to warn others [3] about the spread of the disease and its human-to-human transmission, which was being denied by the Chinese government at the time.
1. Xiao et al (2021) - https://www.nature.com/articles/s41598-021-91470-2%E2%80%8B%E2%80%8B%E2%80%8B , which includes a co-author of Worobey et al (2022), a leading zoonosis paper states in table 1 that the raccoon dogs were wild caught in Hubei, not farmed as you assert in the piece. This alone rules out raccoon dogs as plausible hosts for two independently sufficient reasons. Firstly, there is unanimity in the literature that the bat ancestral virus to SARS-CoV-2 is in southern Yunnan or South East Asia. Everyone agrees with this, including Shi Zhengli. If a species was wild caught in Hubei, then there would be no explanation of how it acquired the ancestral bat virus, given that Hubei is 1000 miles from southern Yunnan.