Astral Codex Ten

Trevor Klee

11 min read

Trevor Klee

Article

Trevor Klee is a recurring person in the Astral Codex Ten archive, appearing 12 times across 12 issues between March 04, 2021 and October 13, 2025. The archive places it in contexts such as “On the Kossin paper showing worsening hurricanes, Trevor Klee writes”; “Trevor Klee writes: I did a college research paper on the changes in hurricanes”; “Trevor Klee writes a blog post of his own”. It most often appears alongside FDA, Scott, Substack.

Metadata

  • Category: People
  • Mention count: 12
  • Issue count: 12
  • First seen: March 04, 2021
  • Last seen: October 13, 2025

Appears In

Source Context

Recovered passages from the original issue text. When the raw archive preserved outbound links inside the source passage, they are listed directly under the quote.

Highlights From The Comments On March Links
March 04, 2021 · Original source
On the Kossin paper showing worsening hurricanes, Trevor Klee writes:
Inline links: Kossin paper, Trevor Klee
Highlights From The Comments On Aducanumab
August 20, 2021 · Original source
Trevor Klee writes a blog post of his own: From A Small Biotech Startup’s Perspective, the FDA Is Terrifying.
Inline links: From A Small Biotech Startup’s Perspective, the FDA Is Terrifying
Links For November
November 25, 2021 · Original source
Boris Johnson (left) is 5’9, so the guy in the middle must be gigantic. Who is he? Looks like it’s Milo Djukanovic, President of Montenegro, who’s 6’6 (198 cm). Is he the tallest world leader? It seems like he’s tied with his colleague across the border, Serbian president Aleksandar Vucic. Why are Balkan leaders so tall? As usual, the answer is “genetics”. This article says: It has been noted that men from Herzegovina are taller on average than men in other places—the average male height is just over six feet...Putting all the data together, researchers concluded that the most likely cause of larger-than-average height of Herzegovinian men is lifestyle during the Paleolithic—men hunted large animals such as mammoth for survival—such a diet, heavy in protein, combined with small population densities, would have provided ideal conditions for height selection, resulting in increasingly taller men who passed the trait down through their I-M170 chromosome to future generations. Some sources note that they manage to beat the Dutch despite the latter country’s much higher human development index. The Dutch are probably tall through a combination of nature and nurture; Balkan people are tall through nature alone. 7: Eliezer Yudkowsky doesn’t need more ego boosts, but an idea he had a couple of years ago - using strings of bright lights to provide a better and brighter experience for Seasonal Affective Disorder sufferers than regular light boxes - spread from him to the rationalist community to the wider world, and has finally gotten tested in a formal study (see Acknowledgments section). Results seem vaguely positive: "SAD symptoms of both groups improved similarly and considerably...exploratory analyses indicate that a higher illuminance is associated with a larger symptom improvement in the BROAD light therapy group" 8: Percent of people who choose woke options on polls very tentatively and preliminarily seems to be going down post-Trump (h/t Richard Hanania). 9: Twitter conspiracy theories 10: Did you know: all those reconstructions of “how classical art would have looked with the original paint” are probably inaccurate. There is no reason to think the Greeks and Romans used garish technicolor hues on their statues; what evidence we have suggest they were good at shading, and the statues were probably colored very tastefully. 11: Complaints about how Karl Friston uses the term “Markov blanket” 12: Trevor Klee on the claim that cyclosporine patients don’t get dementia. Apparently there was a big study where basically nobody on the immunosuppressant cyclosporine ever got dementia, and there are some theoretical reasons why cyclosporine might prevent neurodegeneration. But another study found people on cyclosporine got dementia at the usual rate. I think in a situation like this you should have a really high prior on “the people who got the crazy result bungled their study somehow”, but I’m interested in hearing what other people think. 13: Also from Trevor: a history of fluvoxamine treatment for COVID. 14: To tide you over until the next book review contest, here is awanderingmind’s review of The Conquest Of Bread. 15: Claims: cnbc.com/2021/11/05/sam…\nft.com/content/dcb75a… (better article, but paywalled)","username":"moskov","name":"Dustin Moskovitz","profile_image_url":"","date":"Fri Nov 05 15:49:46 +0000 2021","photos":[],"quoted_tweet":{},"reply_count":0,"retweet_count":184,"like_count":1188,"impression_count":0,"expanded_url":{"url":"https://www.ft.com/content/dcb75a56-ca23-439c-96db-56483979bf34","image":"https://bucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com/public/images/80a58c96-c72f-4301-b571-aa9384f132bd_2400x1350.jpeg","title":"Subscribe to read | Financial Times","description":"News, analysis and comment from the Financial Times, the worldʼs leading global business publication","domain":"ft.com"},"video_url":null,"belowTheFold":true}" data-component-name="Twitter2ToDOM"> 16: Big trial on Vitamin D for depression finds null result. Peter Attia tries to tear it apart here, but I am unconvinced, especially in the context of Vitamin D never working for any of the things people say it does besides the most boring aspects of bone health. 17: “California is actively considering the adoption of flawed and inequitable guidance on math curricula based on misleading data and inaccurate success metrics reported by San Francisco Unified School District (SFUSD)...Based on our review of the data, we found misleading, unsupported, and cherry-picked assertions of success for the new math program. We noted that overall test scores are down and enrollments in UC-approved advanced math classes have dropped as well.” It looks like San Francisco is trying the good old “lower standards, then when more kids meet the standards, claim your school reform plan worked” trick again. 18: A new study claims that self-reported “Long COVID” symptoms are more associated with believing you’ve had COVID than with actually having it (as measured by serologic testing), which sounds like pretty strong evidence that it’s psychsomatic. Expert reactions are mixed-to-negative, although the only one of these that doesn’t sound like excuse-making is Dr. Rossman’s about the unreliability of the tests. I haven’t confirmed test reliability stats but Philippe Lemoine also thinks this is a plausible confounder. 19: Noahpinion: What If Xi Jinping Just Isn’t That Competent? I appreciated this for making me think, and for underlining the extent of the difference between the Deng/Jiang/Hu era and what Xi’s doing. I especially appreciated this line, which I’d never thought about before: Xi presided over the end of China’s hypergrowth. To some extent this is not his fault. No country can grow at 10% forever, and there were many structural forces pushing downward on China’s numbers — the end of the demographic dividend, the exhaustion of rural surplus labor (the Lewis Turning Point), the saturation of export markets, and so on. But China is also slowing down earlier than South Korea, Taiwan, or Japan did in their day. China’s per capita GDP (at PPP) is still only about 1/3 that of a developed country, so if they stop catching up at about half of developed-country levels, that will not be a great showing. A big lesson of the past twenty years has been “actually liberal democracy isn’t necessary to reach developed-country status”, so it would be quite the twist if it turned out you needed liberal democracy to reach developed-country status. This gets pretty close to the great mystery of why some less-developed countries “catch up” and others don’t; whatever happens in China is going to be a really useful data point. 20: Variations on the fable of The Frog And The Scorpion. 21: You’ve probably heard about the University of Austin, the new project by a bunch of wokeness-critical academics to start a new university that won’t cancel people or force conformity (New York Post article, Politico article - these were the two least “you need to be super-outraged about this right now” articles I could find). Tyler Cowen and Larry Summers are involved; Steven Pinker was supposed to be but left for unclear reasons. My thoughts, in no particular order: Even forgetting the political aspect, attempts to start new universities are always welcome.
Inline links: Milo Djukanovic, Aleksandar Vucic, This article, in a formal study, Richard Hanania, Twitter conspiracy theories, There is no reason to think, Complaints about, cyclosporine patients don’t get dementia, a history of fluvoxamine treatment for COVID, The Conquest Of Bread, Vitamin D for depression, here, is trying, A new study, Expert reactions, Philippe Lemoine also thinks, What If Xi Jinping Just Isn’t That Competent?, Lewis Turning Point, slowing down earlier, per capita GDP (at PPP), the great mystery, Variations on the fable of The Frog And The Scorpion, New York Post article, Politico article
ACX Grants Results
December 28, 2021 · Original source
Trevor Klee, $20,000, to help with pharmacokinetic modeling of a possible treatment for neurodegenerative and autoimmune diseases in advance of phase 1 trials. You may have already read some of Trevor's excellent essays on pharmacology, and I look forward to reading more about his successes and failures leading his new pharmaceutical startup. He's looking for a technical cofounder/CSO who's interested in drug repurposing, neurodegeneration, or autoimmune diseases. If that sounds like you or someone you know, please reach out through https://highwaypharm.com/
Inline links: Trevor Klee, essays on pharmacology, https://highwaypharm.com/
Open Thread 212
February 21, 2022 · Original source
2: ACX Grants recipient Trevor Klee writes:
Open Thread 242
September 18, 2022 · Original source
3: ACX Grants winner Trevor Klee asks me to broadcast the following message:
ACX Grants: Project Updates
November 04, 2022 · Original source
5: Develop Safer Immunosuppressants (7/10) Trevor Klee planned to continue his work to develop a safer slow-release form of cyclosporine. He realized this would be too expensive to do in humans in the current funding environment, and has pivoted to getting his medication approved for a feline autoimmune disease as both a proof-of-concept and as a cheaper, faster way to start making revenue. He recently raised $100,000 in crowdfunding (in addition to getting $200,000 from angel investors to run a feline trial, which will finish in January. He still anticipates eventually moving back to humans. Trevor wants to talk to bloggers or writers who might be interested in covering his work.
Inline links: $100,000 in crowdfunding
Trevor Klee wants to talk to bloggers or reporters interested in covering his work to develop better immunosuppressants; contact him at trevor@highwaypharm.com.
Links For April 2023
April 20, 2023 · Original source
28: Trevor Klee’s “Birthright” trip to Tulsa, Oklahoma. Tulsa has some oil billionaires fighting to keep it a good place to live while the rest of the Midwest hollows out, apparently successfully. In particular, two of the billionaires are Jewish and want to preserve Tulsa’s Jewish community. They’re offering very lucrative packages of benefits (including guaranteed cushy jobs at their nonprofits, or extraordinary levels of financial support for creative/business projects) to Jews who move to Tulsa.
Inline links: Trevor Klee’s “Birthright” trip to Tulsa, Oklahoma
Links for May 2024
May 29, 2024 · Original source
17: Only reporting this one out of duty: pharma researcher/blogger Trevor Klee posted a list of concerns about Lumina’s anti-cavity probiotic. Many of them seemed to misunderstand the science involved, and a few were outright false. I was particularly annoyed about the claim that I had gotten a free sample “in exchange for good publicity” - I specified on my public, easy-to-find blog post that I got it because my wife consulted for the company.
Inline links: a list of concerns
Links For September 2024
September 12, 2024 · Original source
27: Related: Trevor Klee’s impressions after visiting California.
Inline links: Trevor Klee’s impressions after visiting California.
Links For April 2025
April 22, 2025 · Original source
13: Local pharma startup founder Trevor Klee is working on a supplement that prevents your body from absorbing plasticizers in food. These aren’t exactly the same as microplastics, but are probably also bad. You would have to take the supplement with every meal - but surely no price is too high if it keeps you safe from . . . whatever it is that plasticizers do.
Inline links: a supplement that prevents your body from absorbing plasticizers in food
ACX Grants Results 2025
October 13, 2025 · Original source
Health: Simon Grimm, Trevor Klee, Eryney Marrogi