Scotland

Article

Scotland is a recurring place in the Astral Codex Ten archive, appearing 14 times across 14 issues between June 14, 2021 and October 01, 2025. The archive places it in contexts such as “Scottish people were extraordinarily over-represented in Britain”; ""economic growth, trade, and an improving intellectual climate in Scotland""; “Does … Scotland?“. It most often appears alongside China, Russia, Switzerland.

Metadata

• Category: Places
• Mention count: 14
• Issue count: 14
• First seen: June 14, 2021
• Last seen: October 01, 2025

Appears In

• Contra Smith On Jewish Selective Immigration
• Who Gets Self-Determination?
• Highlights From The Comments On Self-Determination
• Meetups Everywhere 2022: Times & Places
• The Question Of Separatism
• Meetups Everywhere 2023: Times & Places
• ACX Grants Results 2024
• Links For February 2024
• Your Book Review: The Family That Couldn’t Sleep
• Altruism And Vitalism As Fellow Travelers
• H5N1: Much More Than You Wanted To Know
• Highlights From The Comments On Missing Heritability
• Your Review: Joan of Arc
• The Fatima Sun Miracle: Much More Than You Wanted To Know

Related Pages

• • China (7 shared issues)
• • Russia (6 shared issues)
• • Switzerland (6 shared issues)
• • UK (6 shared issues)
• • Britain (5 shared issues)
• • France (5 shared issues)
• • Germany (5 shared issues)
• • India (5 shared issues)
• • Israel (5 shared issues)
• • Italy (5 shared issues)
• • Spain (5 shared issues)
• • USA (5 shared issues)

External Links

• • http://web.archive.org/web/20221104130431/https://stevekirsch.substack.com/p/1m-bet-rules
• • http://web.archive.org/web/20221129133112/https://blog.rootclaim.com/rootclaim-accepts-500000-challenge-on-covid-vaccine-safety-efficacy/
• • http://web.archive.org/web/20221224061743/https://www.skirsch.com/covid/SaarWilf.pdf
• • https://archive.ph/pY4gF#selection-663.103-683.190
• • https://en.wikipedia.org/wiki/John_von_Neumann
• • https://ericturkheimer.substack.com/p/is-tan-et-al-the-end-of-social-science/comment/106431494
• • https://newrepublic.com/post/173668/republicans-declare-banning-universal-free-school-meals-2024-priority
• • https://web.archive.org/web/20230104080248/https://www.rootclaim.com/
• • https://www.bbc.com/news/uk-scotland-highlands-islands-65694397
• • https://www.newsweek.com/javier-milei-rent-control-argentina-us-election-kamala-harris-housing-affordability-1938127
• • https://www.nytimes.com/2020/12/27/business/media/heather-cox-richardson-substack-boston-college.html

Source Context

Recovered passages from the original issue text. When the raw archive preserved outbound links inside the source passage, they are listed directly under the quote.

Contra Smith On Jewish Selective Immigration

June 14, 2021 · Original source

It would not be the first time something like this happened. The 1700s and 1800s are sometimes called the "Scottish Golden Age". Scottish people were extraordinarily over-represented in Britain and the former British colonies during that time, in science and academia, in business and industry, in politics, and even in the upper ranks of the military. Anecdotally, people in the 1800s compared Scots favorably to Jews. Today, though I suspect Scots would still stand out somewhat on average if anyone was able to track ancestries carefully, Scottish overachievement is not really a hot topic. I can easily see the same happening to Jews, especially given ultra-low Jewish fertility rates (sure to be lower among the rich and educated), and the trend toward outmarriage among non-Orthodox Jews; the Jewish upper crust will simply evaporate away from the Jewish group identity.

Inline links: "Scottish Golden Age", compared Scots favorably to Jews, trend toward outmarriage among non-Orthodox Jews

On the one hand, I agree that this question has lots of interesting context - though I would have chosen the history of other "market minorities" like the Lebanese or the Chinese in Southeast Asia. On the other, I'm not sure that the Scottish Golden Age is really appropriate. I'm not an expert in this period, but it sounds like the kind of thing that had something to do with increased economic growth, trade, and an improving intellectual climate in Scotland. Just to randomly speculate, Scotland had just joined in a Union with England, right as England was inventing industrialization - surely a good climate for a Golden Age to start in. It's much harder to explain Jewish achievement through similar means, because Jews are so intermixed with other populations. Whatever political and economic currents were affecting Albert Einstein or Noam Chomsky or whoever else, ought to also be affecting their Gentile friends and neighbors too. How come they didn't? To me that's a much bigger mystery than whatever happened in Scotland.

But I guess you could also try to rephrase this into something like: there was a Scottish Golden Age for a few centuries, then the Scots stopped being so golden. Maybe sometimes groups of people just become very interesting and successful for a while, and then that dies down again. This doesn't solve the mystery of Jewish achievement, but it contextualizes it and makes it less unique.

Who Gets Self-Determination?

March 30, 2022 · Original source

I find all of this unsatisfying. It’s like we’re debating whether a certain region has enough history and culture to “deserve” independence. But any such debate is inherently subjective. Does Texas qualify? Kurdistan? Scotland? Palestine? How should we know?

Highlights From The Comments On Self-Determination

April 06, 2022 · Original source

This is a lot like the current system except that I think if ethical people happen to be in charge of a country, they have a (weak, potentially balanced by other things) obligation to let people leave, even if they’re not especially oppressed. This seems to be the way the UK is treating Scotland, and I give them a lot of credit for it.

Meetups Everywhere 2022: Times & Places

August 26, 2022 · Original source

VIENNA, AUSTRIA Contact: Manuel, manuel[dot]turonian[at]gmail[dot]com Time: Saturday, September 10, 2:00 PM Location: Wiener Stadtpark at the Strauss Monument; will have an ACX Meetup sign. Coordinates: 8FWR693H+GP2 Event link(s): LessWrong Group info: Rationality Vienna is a group of about 30 people who meet once a month in person or via Zoom. You can join our Facebook group. Notes: We may want to shift to an indoor location depending on weather and the local Covid numbers. BRUSSELS, BELGIUM Contact: Bruno D, bruno[dot]astral[dot]codex[at]gmail[dot]com Time: Sunday, September 18, 4:00 PM Location: Guingette Henri, George Henri parc Coordinates: 9F26RCWC+84 Event link(s): LessWrong SOFIA, BULGARIA Contact: Anastasia, sofia[dot]acx[dot]meetup[at]gmail[dot]com Time: Saturday, September 17, 4:00 PM Location: Shade Garden (Сенчестата градинка; part of Borisova garden) Coordinates: 8GJ5M8GW+J9 Event link(s): LessWrong Group info: Sofia ACX started with last year's Meetups Everywhere round. We have Serious Meetups once per month at which we discuss a blog post, a short story, or a book (for instance, The Scout Mindset, The Money Illusion, The Metropolitan Man); and sporadic non-serious social meetups that mostly include getting dinner, going on a walk, watching a film, or playing board games. Attendance hovers around 6-8 people out of a pool of 13. People get invited to the Discord server after they've attended at least one in-person meetup. ZAGREB, CROATIA Contact: DJStern, dorian[dot]sternvukotic[at]gmail[dot]com Time: Saturday, September 3, 6:00 PM Location: Krivi Put Coordinates: 8FQQRX38+V6W Event link(s): LessWrong Group info: Croatian LessWrong active group communicates mainly through a Telegram group, we meetup semi regularly, approx once a month. The group is mostly social, and the meetups are not structured (sometimes we all just meet at a random party) Notes: Send me an Email and I will add you to a Telegram group where everything (active) LessWrong Croatia/Zagreb happens LIMASSOL, CYPRUS Contact: Arseniy, runescape[at]list[dot]ru, @anchorheld (Telegram / Instagram) Time: Saturday, September 3, 12:00 PM Location: By the Municipal Zoo Coordinates: 8G6MM3M3+Q6 Event link(s): LessWrong Notes: Please hit me up on Mail, Telegram, or Instagram if you're actually going PRAGUE, CZECH REPUBLIC Contact: Jiri Nadvornik, jiri[dot]nadvornik[at]efektivni-altruismus[dot]cz Time: Thursday, October 6, 6:00 PM Location: Garden of Dharmasala Teahouse Coordinates: 9F2P3CRW+FP7 Event link(s): LessWrong, Facebook event COPENHAGEN, DENMARK Contact: Søren Elverlin, soeren[dot]elverlin[at]gmail[dot]com Time: Saturday, September 24, 3:00 PM Location: Rundholtsvej 10, 2300 København S Coordinates: 9F7JMH38+GFP Event link(s): LessWrong, Facebook event, Meetup.com Notes: Please RSVP on LessWrong TALLINN, ESTONIA Contact: Andrew W, andrew_n_west[at]yahoo[dot]co[dot]uk Time: Monday, September 26, 7:00 PM Location: St Vitus, Tallinn. I don't know if anyone will turn up, but I'll be wearing a suit, a beard, and a book. Coordinates: 9GF6CPRH+MQ Event link(s): LessWrong HELSINKI, FINLAND Contact: Joe Nash, joenash499[at]gmail[dot]com Time: Saturday, September 3, 4:00 PM Location: Restaurant Töölönranta, Helsinginkatu 56 Coordinates: 9GG65WMJ+2J Event link(s): LessWrong Group info: LessWrong group FONTAINEBLEAU, FRANCE Contact: Ebrahim Akbari, ea[dot]akbari[at]gmail[dot]com Time: Saturday, September 10, 6:00 PM Location: Glasgow bar, Fontainebleau Coordinates: 8FW4CP32+J8 Event link(s): LessWrong PARIS, FRANCE Contact: Olivier, w20l2qtf[at]mailer[dot]me, We have a Discord and a matrix server (both servers are bridged together) Time: Friday, September 23, 6:00 PM Location: In the jardin du carrousel, next to jardin des Tuileries Coordinates: 8FW4V86J+GH Event link(s): LessWrong Group info: Regular meetups organized via discord or the newsletter every 3 months with around 20 people. Notes: We have a mailing list if you are interested in future meetups. Please don't hesitate to send me an email to RSVP that you're coming to help gauge the interest. TOULOUSE, FRANCE Contact: Alfonso, barsom[dot]maelwys[at]gmail[dot]com Time: Saturday, October 8, 7:00 PM Location: Bar 'Le Biergarten' (60 Gd Rue Saint-Michel, 31400 Toulouse). We'll be sitting at a table with an ACX MEETUP sign on it. Coordinates: 8FM3HCQW+9H Event link(s): LessWrong Notes: Please RSVP by email TBILISI, GEORGIA Contact: Evgenia Karunus, lakesare[at]gmail[dot]com, https://twitter.com/lakesare Time: Saturday, September 17, 7:00 PM Location: Coffee Place Coordinates: 8HH6MRQ2+WH Event link(s): LessWrong AACHEN, GERMANY Contact: Jörn, acx[at]j[dot]stoehler[dot]eu Time: Tuesday, September 27, 7:00 PM Location: Chico Mendes Coordinates: 9F28Q3HJ+9Q Event link(s): LessWrong Notes: Please RSVP here so I can reserve the right number of tables. BERLIN, GERMANY Contact: Ruben Arslan, ssc[at]alphabattle[dot]xyz Time: Sunday, October 2, 2:00 PM Location: Südplateau Fritz-Schloss-Park Coordinates: 9F4MG9H4+4X Event link(s): LessWrong, Google Calendar Notes: Please RSVP on LessWrong. I'll bring some beverages. COLOGNE, GERMANY Contact: Marcel Müller, marcel_mueller[at]mail[dot]de Time: Saturday, October 8, 5:00 PM Location: Marienweg 43, 50858 Köln, private venue, just ring the bell or follow the sign. Coordinates: 9F28WRMX+96H Event link(s): LessWrong Group info: LW / ACX / Rationalist meetup group. Monthly, mostly social meetups. Other activities welcome. Unless noted otherwise we will meet at Marienweg 43 in 50858 Cologne on the 2nd Saturday of each month at 5 pm. Please email me to be added to our mailing list where deviations will be posted. Caution! September Meetup will be at a different venue! Notes: If you read this you are welcome. Our Covid rules are still in effect: You must be tested negative on the same day. Self tests will be available at the meetup. If there is any problem, like you do not find us or I did not see your mail, call me +491788862254. FREIBURG IM BREISGAU, GERMANY Contact: Omar, info[at]rationality-freiburg[dot]de Time: Friday, October 14, 6:00 PM Location: FlexRooms, Salzstr. 1, 79098 Freiburg. We will carry a cardboard sign saying “Rationality Freiburg”. Coordinates: 8FV9XVV2+V56 Event link(s): LessWrong, Meetup.com, Website Group info: The group started in May 2022 and before the summer break we had five meetups with 4-11 people attending. Every two weeks seems like a good rhythm, but nothing is set in stone. So far we always read something beforehand and then discussed it, as well as trying some practical exercises such as TAPs and Personal Calibration. Afterwards we went to have dinner and continued talking about everything and anything for hours. Everything is new and flexible, so come and help us improve! Notes: We have a Signal messenger group and ask you to attend a meetup once to be able to join. HAMBURG, GERMANY Contact: Gunnar Zarncke, g[dot]zarncke[at]gmail[dot]com Time: Saturday, September 17, 5:00 PM Location: Kleine Wallanlagen on the lawn near Memorial Holstenglacis. Look for pink blankets; I will also have an ACX sign. Here is an Open Street Map link which also shows the short-cut tunnel from the subway station. Coordinates: 9F5FHX4H+RXC Event link(s): LessWrongLessWrong Notes: Please RSVP on LessWrong KARLSRUHE, GERMANY Contact: Marcus Wilhelm, mail[at]marcuswilhelm[dot]de Time: Saturday, September 24, 3:00 PM Location: Botanischer Garten Karlsruhe Coordinates: 8FXC2C72+85X Event link(s): LessWrong Group info: We meet weekly, alternating offline and online, see our LessWrong page KASSEL, HESSEN, GERMANY Contact: Tobias, Sphinxfire[at]outlook[dot]de Time: Saturday, September 10, 2:00 PM Location: Friedrichsplatz, to the left of the DocumentaHall Coordinates: 9F3F8F6X+R6 Event link(s): LessWrong Group info: Telegram group Notes: Please join the Telegram group if you are interested in coming. It will be helpful for coordinating something beyond 'let's just see who shows up and take it from there', plus, it will also make me feel a lot better on a purely subjective level if I know beforehand that at least one other person is interested. If you prefer the surprise factor of 'knowing as little as possible about who you're going to meet', you can also just write me via E-mail, of course. LEIPZIG, GERMANY Contact: Gunther Forderung, notavailable[at]riseup[dot]net Time: Tuesday, October 4, 6:00 PM Location: In the Lene-Voigt-Park, in the secluded area opposite of the swings Coordinates: 9F3J8CM2+PF Event link(s): LessWrong TÜBINGEN, GERMANY Contact: Emma, emma[dot]tuebingen[at]gmail[dot]com Time: Sunday, October 23, 6:00 PM Location: The ACX/SSC meetup and dinner (with vegan options) will be on October 23rd at the Annette Kade dormitory (Mohlstraße 44, 8FWFG3H5+XR). If you’d like to attend, please write me an email, and I’ll send you an invitation to our WhatsApp group. Coordinates: 8FWFG3H5+XR Event link(s): LessWrong Notes: Please email me to get my phone number. If a lot of people are out of town for the holidays and can't come we could meet on, say, October 1st. I would like to know how many people to expect. ATHENS, GREECE Contact: Spyros, spyros[dot]dovas[at]gmail[dot]com Time: Monday, September 5, 7:00 PM Location: On the plaza in front of the National Library Coordinates: 8G95WMQR+WRP Event link(s): LessWrong, Meetup.com Group info: We have organized 2 events so far, fall and spring, we just sit around and discuss. We have a Whatsapp group that hasn't picked up momentum yet. Notes: Please RSVP on LessWrong or Meetup.com BUDAPEST, HUNGARY Contact: Tim Underwood, timunderwood9[at]gmail[dot]com, WhatsApp 19513120591 Time: Sunday, September 11, 2:00 PM Location: Champs Sziget bar on Margit Sziget, near the front. I'll have a big hardcover copy in Hungarian of a book by Richard Dawkins. Coordinates: 8FVXG2CW+2H Event link(s): LessWrong Group info: We've been meeting in Budapest for two years now, with our first meeting being the 2020 ACX meetups everywhere. We meet about once a month, and usually we have two articles that are suggested reading that we discuss. CORK, IRELAND Contact: Mikey, Godojhana[at]gmail[dot]com Time: Thursday, September 29, 6:00 PM Location: If sunny: The Lough. If not, then the game arcade on the parade Coordinates: 9C3HVGQ7+JQ Event link(s): LessWrong DUBLIN, IRELAND Contact: Lucius, lucius[at]bushnaq[dot]de, LessWrong profile Time: Sunday, October 2, 12:30 PM Location: Clement & Pekoe, William Street South, Dublin 2. We'll be sitting inside, and there'll be a sign with ACX written on it on the table Coordinates: 9C5M8PRP+JV Event link(s): LessWrong Group info: LessWrong FOLIGNO, ITALY Contact: Mauro, orfino[at]yandex[dot]com, LW profile, Telegram Time: Saturday, September 24, 5:00 PM Location: Parco dei Canapé, at the open air cafe, ask the barista Coordinates: 8FJJXP22+HC Event link(s): LessWrong Notes: Please RSVP on LessWrong so I know how much food to get. No kids please. MILANO, ITALY Contact: Raffaele, raffa[dot]mauro[at]gmail[dot]com Time: Friday, September 16, 6:30 PM Location: Viale Luigi Majno, 18, 20129 Milano MI - Primo Ventures / T8P, IInd floor. Coordinates: 8FQFF6C4+9C Event link(s): LessWrong Group info: We meet once per month. The group started in May 2022. Notes: Please RSVP by email by the 1st of September PADOVA, ITALY Contact: Carlo, carlo[dot]martinucci[at]gmail[dot]com Time: Saturday, October 1, 3:30 PM Location: Prato della Valle, fountain in the middle. I'll be carrying a sign with ACX MEETUP on it :) Coordinates: 8FQH9VXG+9J Event link(s): LessWrong Notes: We'll probably find a bar to have a hot chocolate or tea or something :) PISA, ITALY Contact: Raffaele, raffaelesalvia[at]alice[dot]it Time: Saturday, October 22, 5:00 PM Location: We will meet in Piazza dei Cavalieri, near the steps of Palazzo della Carovana Coordinates: 8FMGPC92+R44 Event link(s): LessWrong ROMA, ITALY Contact: Grigorio, greghero12[at]gmail[dot]com, Facebook, +393920366026 Time: Saturday, October 8, 6:00 PM Location: We'll be around Gardenie metro station, at the benches, and I will be wearing a red shirt and sitting on top of the station to be seen Coordinates: 8FHJVHP9+8F Event link(s): LessWrong Group info: We meet around 20-25 times a year but it is asymmetrical, focused in summer, Christmas and Easter. We discuss opinions, engage in circling, play games where we spot logical fallacies and biases by attacking our members ideological weakpoints and formalize some debating stances. Occasionally we find the willpower to devote meetups in steelmanning and understanding the outgroup (roughly 4-5 times a year) Notes: If you are into ACX enough to see this post, I believe we have enough common ground to be worth meeting each other. Aren't you curious who else is within this niche community in Rome? Come on, take a leap of faith. P.S. Would be nice if you sent me a message in WhatsApp with your name and probability of attendance, but I love walk-ins just fine. No space limit after all ;-) RIGA, LATVIA Contact: Andis, cerulean[dot]lemniscate[at]protonmail[dot]com Time: Saturday, September 17, 4:00 PM Location: Bastejkalns (on top of the hill) Coordinates: 9G86X426+Q5Q Event link(s): LessWrong AMSTERDAM, NETHERLANDS Contact: Pierre, pierreavdb[at]gmail[dot]com Time: Saturday, September 10, 3:00 PM Location: Kanarie Klub (Bellamyplein 51, 1053 AT Amsterdam) Coordinates: 9F469V89+W4 Event link(s): LessWrong Group info: The rationality community is growing in the Netherlands, and we're now planning on having monthly meetups! Join the Rationality NL Discord server. Notes: Please RSVP on LessWrong so I can plan a different venue if needed DELFT, NETHERLANDS Contact: Pierre Bongrand, bongrand[dot]pierre[at]gmail[dot]com, 0033620644013 (Whatsapp/Telegram/Signal) Time: Thursday, September 22, 6:30 PM Location: Delftse Hout Beach, on the grass, in the center of the beach, I will be wearing a red T-shirt and carrying a sign with ACX MEETUP on it. Coordinates: 9F4629FG+66 Event link(s): LessWrong HATTEM, NETHERLANDS Contact: Shoshannah, shos[dot]rationality[at]gmail[dot]com, Discord: Dark#0849 Time: Saturday, October 8, 2:00 PM Location: Lijsterbeslaan 6, Hattem Coordinates: 9F48F378+PR Event link(s): LessWrong, Facebook event Group info: We support and coordinate groups across the country, including everything from social meetups to structured events and applied rationality. The intention is to connect all Dutch rationalists and rationalists in the Netherlands. We also discuss rationality topics online and coordinate events on our Discord server. Notes: Feel free to bring kids. Ours will be there :) Also, please park 't Heem if you are coming by car. It's a 2 minute walk to our house. HELMOND, NETHERLANDS Contact: Rutger, silvery[dot]swift[at]protonmail[dot]com Time: Saturday, September 17, 3:00 PM Location: De Motte (On top of the hill). Nearest road is Palladio. Coordinates: 9F37FMC5+VR Event link(s): LessWrong THE HAGUE, NETHERLANDS Contact: Kristof Redei, acxmeetup[at]kristof[dot]me Time: Wednesday, September 14, 6:00 PM Location: Paleistuin, Prinsessewal, 2513 EE Den Haag, Netherlands. We'll have a picnic blanket with an ACX sign on the large central field, somewhere near the playground. Coordinates: 9F4638J3+GP Event link(s): LessWrong, Facebook event Notes: Please RSVP on Facebook if possible! All ages/species welcome. If it's not outdoor weather, we'll go to The Bookstor Cafe next door as a backup. OSLO, NORWAY Contact: Hans Andreas & Jonas, acxoslomeetup[at]gmail[dot]com Time: Saturday, September 17, 1:00 PM Location: Look for the sign of Moloch at Café Billabong - Bogstadveien 53B 0366 Oslo Coordinates: 9FFGWPH7+QP Event link(s): LessWrong, Meetup.com Group info: We're hoping to do at least a quarterly meetup, but we'll base it on the turnout and enthusiasm of this event. Notes: The cafe has historically been accepting of guests' not ordering--please don't let financial reasons keep you away! GDAŃSK, POLAND Contact: Frank, frankastralcodexten[at]gmail[dot]com, Discord: frhrpr#1663 Time: Saturday, August 27, 3:00 PM Location: Next to Park Kuźniczki, opposite the train station, on the circular benches around the water pump; I will be wearing a red armband Coordinates: 9F6W9JJ4+JW Event link(s): LessWrong KRAKÓW, POLAND Contact: Mateusz Bagiński, bagginsmatthew[at]gmail[dot]com Time: Saturday, September 17, 2:30 PM Location: Celna 6/9, the office of the Optimum Pareto Foundation Coordinates: 9F2X2WVX+V2 Event link(s): LessWrong, Facebook event Group info: We meet every month, here is our Facebook group. LUBLIN, POLAND Contact: Piotr, piotrekzlublina[at]gmail[dot]com Time: Saturday, September 17, 5:00 PM Location: Między Słowami cafe, Rybna 4, Lublin Coordinates: 9G346HX8+FX Event link(s): LessWrong POZNAŃ, POLAND Contact: Ofelia Kerr, ofel[dot]kerr[at]gmail[dot]com, Discord: ofelia#0001 Time: Saturday, October 8, 6:00 PM Location: Van Gogh Pub, Żydowska 12, 61-761. I'll most likely be on the ground floor and I'll have an ACX sign. Coordinates: 9F4RCW5P+X3F Event link(s): LessWrong WARSAW, POLAND Contact: Michał, rationalwarsaw[at]gmail[dot]com Time: Sunday, September 4, 6:00 PM Location: Południk Zero, Wilcza 25 Coordinates: 9G4362G8+2V Event link(s): LessWrong, Meetup.com Group info: The community of Warsaw LessWrong/SSC/ACX/etc. readers is active for over 8 years now. We're trying to organise regular monthly meetups. You can join our Facebook group or Meetup.com. LISBOA, PORTUGAL Contact: Luís Campos, luis[dot]filipe[dot]lcampos[at]gmail[dot]com Time: Saturday, September 10, 3:00 PM Location: Jardim Amália Rodrigues, close to Linha d'Água cafe, in the top of a hill, below a bunch of trees Coordinates: 8CCGPRJW+V8 Event link(s): LessWrong Group info: We've been meeting every month for around 1 year. Get in contact if you want to participate in the WhatsApp group. :) BUCHAREST, ROMANIA Contact: Tony, skyrimtracer[at]gmail[dot]com Time: Sunday, October 16, 3:00 PM Location: Plaza România Mall, Bd. Timișoara 26 - food court Coordinates: 8GP8C2HM+9X Event link(s): LessWrong Notes: Please RSVP by email CLUJ-NAPOCA, ROMANIA Contact: Marius Pop, pop[dot]marius[at]gmail[dot]com Time: Saturday, September 3, 11:00 AM Location: Deva Host, Strada Deva 1-7 Coordinates: 8GR5QH8F+MW Event link(s): LessWrong BELGRADE, SERBIA Contact: Ivica Bogosavljevic, ibogosavljevic[at]gmail[dot]com, Viber +381 65 3473 433 Time: Monday, September 12, 6:00 PM Location: Pool Cafe on Prve pruge Coordinates: 8GP2RCP7+G7 Event link(s): LessWrong Notes: Please RSVP on my Viber number, so I know how big the room we need. BRATISLAVA, SLOVAKIA Contact: Viliam, viliam[at]bur[dot]sk Time: Saturday, September 10, 3:00 PM Location: Medická záhrada, by the fountain Coordinates: 8FWV44X9+XW8 Event link(s): LessWrong Notes: I will post an announcement on LessWrong later. In case of rain, a new meeting place nearby will be announced there. LJUBLJANA, SLOVENIA Contact: Demjan Vester, demjan[dot]vester[at]gmail[dot]com Time: Wednesday, September 14, 6:00 PM Location: Probably Lili Novy bar, near modern gallery and park Tivoli Coordinates: 8FRP3F3X+6V Event link(s): LessWrong, Meetup.com Group info: We meet about 0.7 times a month. Notes: Please RSVP because last time we just barely got a place big enough. BARCELONA, SPAIN Contact: Alfonso, alfonso[dot]martinez[at]upf[dot]edu, WhatsApp +34693846738 Time: Sunday, October 2, 5:30 PM Location: Parc de la Ciutadella, by the Lion Catcher statue; I'll have an ACX sign Coordinates: 8FH495QP+96 Event link(s): LessWrong Notes: The idea is to sit on the grass; bring a foulard along for your comfort, or a foldable chair if preferred. Don't worry about the language: English, Spanish, Catalan, we'll find a way. MADRID, SPAIN Contact: Jaime, jaimesevillamolina[at]gmail[dot]com Time: Saturday, September 10, 5:00 PM Location: Teatro de títeres del Parque del Retiro. We'll be on the stands with an ACX sign Coordinates: 8CGRC897+F8C Event link(s): LessWrong Group info: We are an EA / rationality group, we've been active for around 5 years but have less in-person activity since the pandemic started. We have a WhatsApp group and a channel in the Spanish-speaking EA Slack. SEVILLA, SPAIN Contact: Edu, edur[dot]acx[at]gmail[dot]com Time: Saturday, September 10, 8:00 PM Location: Parque de María Luisa. I'll be on the grass behind the Museum of Popular Arts and Traditions. I'll be the guy next to an ACX sign, a white wooden chair, and a cardboard ukulele with a tiny cardboard hat on it. Coordinates: 8C9P92F6+3RG Event link(s): LessWrong GOTHENBURG, SWEDEN Contact: Joacim, joacimj[at]gmail[dot]com Time: Saturday, September 24, 3:00 PM Location: Condeco Fredsgatan. I'll have a stack of three books on my table. Coordinates: 9F9HPX4C+39G Event link(s): LessWrong, Facebook event STOCKHOLM, SWEDEN Contact: Sal, niktonick[at]gmail[dot]com, Telegram Time: Sunday, September 25, 3:00 PM Location: Humlegården, Karlavägen. We will meet near blue gazebo, I will have 'ACX meetup' sign. Coordinates: 9FFW83RF+3M5 Group info: Facebook group BERN, SWITZERLAND Contact: Daniel, dd14214+acx[at]gmail[dot]com Time: Sunday, October 2, 4:00 PM Location: Grosse Schanze, at the statue in front of the main uni building, heading to the Pittaria if it's cold or raining Coordinates: 8FR9XC2Q+4G Event link(s): LessWrong GENEVA, SWITZERLAND Contact: Eric, eric[dot]c[dot]p[dot]meier[at]gmail[dot]com Time: Sunday, September 11, 4:00 PM Location: Park de la Grange, just towards the lake below Villa de la grange Coordinates: 8FR86548+J4 Event link(s): LessWrong Group info: We have a small persistent group who has tried to meet up once a month since last years Meetup. Notes: Feel free to bring other people you think would be interested! ZURICH, SWITZERLAND Contact: MB, acxzurich[at]proton[dot]me Time: Saturday, September 24, 3:00 PM Location: TBD Event link(s): LessWrong ISTANBUL, TURKEY Contact: J, jinai[dot]jyap[at]gmail[dot]com Time: Sunday, September 25, 4:00 PM Location: The House Cafe in Ortaköy. I am a young Asian woman and imagine I'll be easy to spot, but will also try to bring a sign with ACX MEETUP on it. Coordinates: 8GHF22XG+23P Event link(s): LessWrong, Partiful Group info: I do not live here; I am just digital nomading for an indefinite amount of time and would like to meet anyone who's here! Notes: Please RSVP via the Partiful link (you can RSVP as a Maybe)! BIRMINGHAM, UK Contact: Thomas Read, thomas[dot]read[dot]acx[at]gmail[dot]com Time: Saturday, September 3, 1:00 PM Location: We'll be at The Wellington, 37 Bennetts Hill, on the roof terrace if possible. I'll wear an orange shirt and have a sign saying ACX on the table. Coordinates: 9C4WF3JX+7Q Event link(s): LessWrong Notes: It's only a few minutes walk from the stations, so hopefully people can join from all over the West Midlands! BRIGHTON, UK Contact: Alan Enright, alanenright[at]protonmail[dot]com Time: Saturday, September 10, 11:00 AM Location: We'll be at the Alcampo Lounge on London Road—we will try and get a table on the raised area in front of you and to the left as you come in but will also have a little ACX sign. Coordinates: 9C2XRVM6+3X Event link(s): LessWrong, Meetup.com BRISTOL, UK Contact: Nick Lowry, bristoleffectivealtruism[at]gmail[dot]com Time: Saturday, September 24, 2:00 PM Location: We’ll be meeting at entrance closet to Tesco Express in the Galleries, Bristol City Centre Coordinates: 9C3VFC45+RJM Event link(s): LessWrong, Facebook event, Meetup.com Group info: Meet twice monthly for socials, more regular 'productive' meetups. Been active for 3+ years, please message for WhatsApp group CAMBRIDGE, UK Contact: Hamish Todd, hamish[dot]todd1[at]gmail[dot]com Time: Saturday, September 17, 2:00 PM Location: Bath House Pub, UPSTAIRS!! I will have a copy of Peter Singer's The Most Good You Can Do Coordinates: 9F426439+J9 Event link(s): LessWrong, Facebook event Group info: We meet on the third Saturday of every month. The group has been around almost a year and is well-attended! Notes: My phone/WhatsApp number is +44 0730 *** 3550, where the *** are replaced by the serial number of the Boeing plane whose first flight was on September 2, 1998. Email me to get on the mailing list for future events if you'd like that :) CARDIFF, WALES Contact: AF, strmnova[at]gmail[dot]com Time: Friday, September 16, 5:00 PM Location: Little Man Coffee (note new location!) Coordinates: 9C3RFRHH+W2 Event link(s): LessWrong EDINBURGH, SCOTLAND, UK Contact: Sam, acxedinburgh[at]gmail[dot]com Time: Saturday, September 24, 2:00 PM Location: Pleasance Cafe. Go through the arch and the door to the cafe is on your left Coordinates: 9C7RWRW9+M8 Group info: ~Monthly meetups, often in Pleasance Cafe but have experimented with other locations. Email me to join the mailing list & WhatsApp group. LANCASTER, UK Contact: Gruffydd Gozali, gruffyddgozali[at]gmail[dot]com Time: Saturday, October 15, 3:00 PM Location: Lancaster University Library, will be on the ground floor by the tree wearing an EA shirt. Coordinates: 9C6V2657+WJR Event link(s): LessWrong LINCOLN, UK Contact: Tobias, tobias[dot]showan[at]yahoo[dot]co[dot]uk Time: Saturday, September 10, 2:00 PM Location: Nosey Parker pub, I'll bring a little paper ACX sign. Coordinates: 9C5X6C9R+XJ Event link(s): LessWrong LONDON, UK Contact: Edward Saperia, edsaperia[at]gmail[dot]com Time: Sunday, September 25, 2:00 PM Location: Newspeak House Coordinates: 9C3XGWGH+3F7 Event link(s): LessWrong, Facebook event, Meetup.com, Eventbrite Group info: You can join our mailing list or our Meetup.com group MANCHESTER, UK Contact: Matthew Gibson, melkartmtg[at]hotmail[dot]com Time: Sunday, September 18, 11:00 AM Location: Sackville Gardens, Alan Turing Memorial Coordinates: 9C5VFQG7+MH Event link(s): LessWrong NEWCASTLE UPON TYNE, UK Contact: Joshua William, iamjoshwilliam[at]icloud[dot]com, Telegram Time: Saturday, September 3, 12:30 PM Location: Trinity Square, High Street Gosforth. You can get the bus to Gosforth from the city center just outside the famous 'Tyneside Cinema' (bus number: 30, 31, or 35 at Monument Pilgrim Street bus stop), or you can take a walk if you want to get your 'steps' in (if you'd like to do the latter, send me an email and I'll send you the directions), which takes ~60-min. Coordinates: 9C7W294H+5V Event link(s): LessWrong Group info: To my knowledge, there isn't an ACX meet up in this city, or region of the UK, though if there is a demand for a reoccurrence, I'd be happy to keep facilitating such. I'd also happily formulate a WhatsApp group if theres interest, after the meet up. Notes: We have a deli, '1901 cafe', on the square, which we can grab an immediate bite to eat at [so save some hunger if you'd like to do that]. There's a safe [and lovely] park with some benches just by the way, which, if the weather is nice, we can sit at after a bite to eat, or, otherwise, we can remain in the cafe. OXFORD, UK Contact: Sam, ssc[at]sambrown[dot]eu, There's a Signal group people can join :) contact Sam for info Time: Wednesday, October 19, 6:30 PM Location: The Star, Rectory Road, Oxford. We'll be in the beer garden round the back, with a sign ?? Coordinates: 9C3WPQX6+QP9 Event link(s): LessWrong, Facebook event, Meetup.com Group info: We run socials every months, and applied rationality workshops from time to time! Notes: Please RSVP on any of the platforms (or email) for free pizza PENRYN, CORNWALL, UK Contact: mini t, tminns[at]btinternet[dot]com Time: Saturday, August 27, 3:00 PM Location: glasney playing field and valley Coordinates: 9C2P5V8V+P9 Event link(s): LessWrong Notes: I don't mind rescheduling, or organizing another event, not many people are likely to turn up this far out of the way.

Inline links: 8FWR693H+GP2, LessWrong, Facebook group, 9F26RCWC+84, LessWrong, 8GJ5M8GW+J9, LessWrong, 8FQQRX38+V6W, LessWrong, 8G6MM3M3+Q6, LessWrong, 9F2P3CRW+FP7, LessWrong, Facebook event, 9F7JMH38+GFP, LessWrong, Facebook event, Meetup.com, 9GF6CPRH+MQ, LessWrong, 9GG65WMJ+2J, LessWrong, LessWrong group, 8FW4CP32+J8, LessWrong, Discord, matrix server, 8FW4V86J+GH, LessWrong, 8FM3HCQW+9H, LessWrong, https://twitter.com/lakesare, 8HH6MRQ2+WH, LessWrong, 9F28Q3HJ+9Q, LessWrong, here, 9F4MG9H4+4X, LessWrong, Google Calendar, 9F28WRMX+96H, LessWrong, 8FV9XVV2+V56, LessWrong, Meetup.com, Website, an Open Street Map link, 9F5FHX4H+RXC, LessWrong, LessWrong, 8FXC2C72+85X, LessWrong, our LessWrong page, 9F3F8F6X+R6, LessWrong, Telegram group, 9F3J8CM2+PF, LessWrong, 8FWFG3H5+XR, 8FWFG3H5+XR, LessWrong, 8G95WMQR+WRP, LessWrong, Meetup.com, 8FVXG2CW+2H, LessWrong, 9C3HVGQ7+JQ, LessWrong, LessWrong profile, 9C5M8PRP+JV, LessWrong, LessWrong, LW profile, Telegram, 8FJJXP22+HC, LessWrong, 8FQFF6C4+9C, LessWrong, 8FQH9VXG+9J, LessWrong, 8FMGPC92+R44, LessWrong, Facebook, 8FHJVHP9+8F, LessWrong, 9G86X426+Q5Q, LessWrong, 9F469V89+W4, LessWrong, Rationality NL Discord server, 9F4629FG+66, LessWrong, 9F48F378+PR, LessWrong, Facebook event, 9F37FMC5+VR, LessWrong, 9F4638J3+GP, LessWrong, Facebook event, 9FFGWPH7+QP, LessWrong, Meetup.com, 9F6W9JJ4+JW, LessWrong, 9F2X2WVX+V2, LessWrong, Facebook event, our Facebook group, 9G346HX8+FX, LessWrong, 9F4RCW5P+X3F, LessWrong, 9G4362G8+2V, LessWrong, Meetup.com, Facebook group, Meetup.com, 8CCGPRJW+V8, LessWrong, 8GP8C2HM+9X, LessWrong, 8GR5QH8F+MW, LessWrong, 8GP2RCP7+G7, LessWrong, 8FWV44X9+XW8, LessWrong, 8FRP3F3X+6V, LessWrong, Meetup.com, 8FH495QP+96, LessWrong, 8CGRC897+F8C, LessWrong, 8C9P92F6+3RG, LessWrong, 9F9HPX4C+39G, LessWrong, Facebook event, Telegram, 9FFW83RF+3M5, Facebook group, 8FR9XC2Q+4G, LessWrong, 8FR86548+J4, LessWrong, LessWrong, 8GHF22XG+23P, LessWrong, Partiful, 9C4WF3JX+7Q, LessWrong, 9C2XRVM6+3X, LessWrong, Meetup.com, 9C3VFC45+RJM, LessWrong, Facebook event, Meetup.com, 9F426439+J9, LessWrong, Facebook event, 9C3RFRHH+W2, LessWrong, 9C7RWRW9+M8, 9C6V2657+WJR, LessWrong, 9C5X6C9R+XJ, LessWrong, 9C3XGWGH+3F7, LessWrong, Facebook event, Meetup.com, Eventbrite, our mailing list, Meetup.com group, 9C5VFQG7+MH, LessWrong, Telegram, Monument Pilgrim Street bus stop, 9C7W294H+5V, LessWrong, 9C3WPQX6+QP9, LessWrong, Facebook event, Meetup.com, 9C2P5V8V+P9, LessWrong

The Question Of Separatism

May 19, 2023 · Original source

An oversized technology force creates a clearance region. The example here is the Scottish Highlands, where a technological innovation was introduced in the late 18th century: a new breed of sheep. (Technically this was a rural invention, but the introduction to Scotland was devised by businessmen in London.) The new sheep greatly improved the yields from the land, but at the cost of violently displacing a large number of poor tenant farmers to make room for pastures. So it goes for other technologies, like farm machinery: when they are introduced to a poor rural region that isn’t integrated into an import-replacing economy, they just replace workers and leave them idle, poorer than before, or forced to emigrate.

The Forbidden Solution All empires eventually collapse. This is not what we would expect if empires were a good economic arrangement. If they only ever got wealthier and wealthier, they wouldn’t disintegrate into various separatist factions or end in foreign conquest. The first empire to form would have slowly absorbed everything else, and we would all be living good lives under the enlightened rule of the Sumerians or whatever. But that doesn’t happen, because empires always milk their own cities until they become poor. Modern nation-states do the same. They accumulate stress by trying to hold themselves together, and then, one day, the stress is released all at once. Wars and revolutions galore. Most countries are born that way, like new stars formed in the aftermath of a supernova. Peaceful separatism offers an alternative, Jacobs says — but only a theoretical one. Jacobs shows us a glimpse of a world in which secessions would be “a normal, untraumatic accompaniment of economic development itself.” Regions would separate when they feel the need to, before decline has set in. “In this utopian fantasy,” she writes, “young sovereignties splitting off from the parent nation would be told, in effect, ‘Good luck on your independence! Now do try your very best to generate [or maintain, as the case may be] a creative city and its region and we’ll all be better off.’” Can you imagine Canada saying this to Quebec? Or England to Scotland? Or China to Tibet and Taiwan? Yeah, me neither. That’s why it’s only theoretical and utopian. Jacobs knows very well that nations will never accept separatism as an option. And though the term “nationalist” has fallen out of fashion, almost all of us still think very much in terms of nations. Even when separatism does seem grudgingly acceptable, I’d say that’s usually either because it’s an instance of decolonization (colonial empires are decidedly out of fashion) or for cultural, nationalistic reasons. Quebecois, Scottish, or Catalan separatists say that they belong to nations that are culturally distinct from Canada, the United Kingdom, or Spain. And they love their smaller nation just as much as others love the larger one. If any of these separatists got their way, we can be sure that the new nation of Quebec, Scotland, or Catalonia would then oppose further separatism in the strongest terms. When the American South seceded from the Union in 1861, the reaction wasn’t “good luck!” even though the Union was itself the result of a secession from Great Britain. To separate for economic reasons seems forbidden. Unthinkable. For one thing, it would be selfish. If Catalonia left, the poor regions of Spain, which benefit from welfare financed in part by Barcelona, would suffer, which is obviously unacceptable to Spain. For another, it’s not guaranteed to work. Small countries and city-states can still adopt dumb economic policies. It can seem intolerably risky to go your own way, unless your region is already rich, in which case see the selfishness point above. Widespread separatism also seems worse for solving large-scale coordination problems, like environmental issues, nuclear proliferation (and, perhaps, AI), or war. I suspect that Jacobs would agree with Nassim Taleb’s antifragility framing: it’s better to be in a constant state of mild disorder than to have apparent stability that hides stressors and ends in violent conflict. But that idea is not intuitive. Most of us would pick apparent stability over mild disorder. I also suspect — and this is my personal take — that we dread the additional complexity of having numerous small countries. We look at a map of medieval Germany, like this one… … and we think, thank goodness that Germany is unified now. So much easier to think about! Can you imagine if the Our World in Data charts had to show separate lines for the Electorate of Saxony, the Prince-Bishopric of Augsburg, the Duchy of Brunswick-Lüneburg, and about 1,800 other semi-sovereign states? Can you imagine traveling around if each of them had its own currency? (Fun fact: the List of states in the Holy Roman Empire Wikipedia page doesn’t contain such a list. Instead it points to no less than 28 sub-lists.) Jacobs stops shy of asking, in either book, the question that seems to be the logical continuation of her reasoning: should everything be a city-state? Should we encourage separatism until each inhabited place in the world is either a city or a city region with its own currency? We can hazard a guess as to what her answer would be. She would probably say that there’s no need to upend everything right this moment. Just adopt an attitude of political openness and experimentation. Don’t try to hold together entities that don’t work that well. When separatist sentiment arises somewhere, you can argue it’s a bad idea, but don’t fight it out of emotion such as fear for your nation’s integrity. Eventually, things will settle — the regions that want to be city-states will be, and those that prefer to be united with others, for cultural or economic reasons, will stay that way. Unity has good PR and some genuine advantages, so there will still be plenty of it. But maybe Jane Jacobs never asks this question because she knows it’s irrelevant. We just can’t help fighting for our big countries and supranational unions (like the EU), and too bad if they enter long periods of stagflation until they violently collapse. This might be the right time to mention that her last book, published in 2004, is called Dark Age Ahead. IV. Something to Dislike For Everyone Jane Jacobs’s most famous book is The Death and Life of Great American Cities. She is recognized as perhaps the most influential thinker in urbanism. She is credited with saving Greenwich Village and SoHo in New York City, and helping cancel the Spadina Expressway in Toronto. To this day people organize “Jane’s Walks” as a living memorial to her impact on cities. But Jane Jacobs herself thought that her greatest intellectual contribution was not in city planning, but in economics. She thought that import replacement was her most important discovery, since it explained how wealth expands better than existing macroeconomic theories. She wrote multiple books that were explicitly about economics and was about to write another when she died, Uncovering the Economy. I am not an economist, so I might not be qualified to make a judgment on this matter, but: it seems to me that there’s a discrepancy here. Jacobs is widely seen as a great intellectual, but her economic ideas don’t quite seem mainstream. I’d never heard of import replacement before reading her book. Why not? The null hypothesis is that economists have examined her ideas and simply rejected them. There were some critical academic reviews of Cities and the Wealth of Nations when it came out, and more recently Tyler Cowen expressed his own mild skepticism. Some of the criticism involves the lack of quantitative data in her work, and her failure to think about issues of scale. The most obvious target, of course, is her city obsession: yes, cities are important, but they’re not the only economic phenomenon that matters, some would say. Perhaps Jacobs has overplayed her hand. But there are other possible explanations for the discrepancy. One is that she was a woman and had no credentials, which made it difficult for (mostly male) professionals to take her seriously. We know this was true at the beginning of her career at least. It seems possible that even after she managed to establish herself as an original urban thinker, economists had trouble accepting that she could, with her lack of any college degree, come up with new insights in their field. I doubt that’s really true today, though. We do take Jacobs seriously, and still read all of her books, which is more than we could say about most economists. Instead, I propose that the discrepancy comes from a darker place: in laboring to be comprehensive about cities and economics, she reached conclusions that most people don’t want to be true. No matter your politics, there’ll be something for you to dislike in Jacobs’s work. For example, it’s pretty clear that she didn’t think the European Union was a good idea, so she probably would have supported Brexit. Brexiters might rejoice, except that a lot of them are British nationalists who certainly don’t want Scotland to leave the UK, whereas Jacobs would agree with that. Which would be great news to Scottish independentists — except that if a new separatist movement arose within Scotland, she’d also support that. Jacobs’s ideas and grassroots activism in favor of small-scale, organic urban planning have come to be seen as left-wing — yet her criticism of national welfare programs wouldn’t make her out of place among hardcore right-wingers. Unless those right-wingers were military hawks, in which case they’d find no solace in reading Jacobs on military transactions of decline. Writing during the Cold War, Jacobs criticized the Soviet Union for its incredible centralization of decision-making in Moscow. She rightfully predicted its collapse, making her an ideological ally of the capitalist West, right? Not so, since the United States is also, according to her, too centralized and in the early stages of decay. “Today the Soviet Union and the United States each predicts and anticipates the economic decline of the other,” she writes. “Neither will be disappointed.” Whether she was correct about the US is left as an exercise to the reader. In any case, she did foresee, using her theory on cities, the decline of Japan. This must have been bold in the 1980s at the peak of the Japanese economic miracle, when there was a widespread trope that Japan would soon take over the world. Yet she was right: in 1991, Japan entered its “lost decade,” which soon became two lost decades, and then three. To be fair, she predicted the decline of all large-ish countries, so I wouldn’t mark her as a superforecaster or anything. Still, this puts in perspective the more recent trope that China is going to take over the world. No country, no ideology is safe from Jacobs’s prophecies. Smaller ideologies aren’t spared, either. Effective altruism would probably seem totally mistaken to her, since at its core it promotes an inorganic, top-down transfer of wealth from prosperous cities to poor areas. Progress studies people think that technological innovation will solve economic stagnation, but she would point out how labor-saving equipment so often causes damage when it is introduced to regions that don’t benefit from the other city forces, like the Scottish Highlands or many of her other examples in Colombia, India, or the American South. (This point would deserve an essay of its own, but reading Jacobs has made me a bit more worried about the “AI will take our jobs” thing. It’s clear that new jobs will appear, but when the technology city force from the San Francisco Bay Area reaches distant places with poor economies, which it will very soon thanks to the internet, the effects might not be very pleasant to see.) Overall, the political ideology that might fit Jacobs the best might be… libertarianism? She’s not a big fan of large governments who make big top-down decisions, clearly. Yet I don’t get the feeling that this association fits all that well either. Jacobs doesn’t seem to be anti-government if the government is at the city level. I doubt she would have liked the kind of hyperfragmented world depicted in Snow Crash by Neal Stephenson. I also doubt she’d be impressed by cryptocurrency-backed “cloud cities” or fantasies of charter cities, none of which she would see as real cities in the sense of concentrated pockets of people who start replacing what they import with local production. Jane Jacobs, in sum, was an archetypal accidental moderate. She took one idea very seriously — the idea that cities are fundamental — and explored its ramifications without caring in the slightest if it led to the “wrong” opinions, as her friends in 1980 Toronto must have thought when she wrote about Quebec. I don’t know if she went too far; I’m sure someone more qualified than I am can find flaws in that core idea or any of her other observations. But to me she sounds convincing, and her consistency is frankly admirable. So, to end this review on a more review-y note, go read Jane Jacobs. Her books are a delight, with their elegant arguments and masterfully told anecdotes. Her predictions often take an air of doom, but she is also an optimist who offers constructive ways forward. She sets an example for all of us who care about getting the details right, no matter the credentialed experts, the current political climate, or the great theories of the past. Image credits Cities and the Wealth of Nations book cover: from Amazon.

Inline links: https://substackcdn.com/image/fetch/$s_!sPn6!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fd25ceff6-f68e-4163-becf-613204a9be35_1600x1297.png, List of states in the Holy Roman Empire, https://substackcdn.com/image/fetch/$s_!gyMq!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fdc388f24-009c-42ee-adca-9d5c50faaa66_932x190.png, academic, reviews, expressed, Japan would soon take over the world, fantasies, of, charter, cities, accidental moderate, https://substackcdn.com/image/fetch/$s_!r8Rb!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F60621c76-b34b-4e10-b272-394480443e1b_1600x1066.png, Amazon

… and we think, thank goodness that Germany is unified now. So much easier to think about! Can you imagine if the Our World in Data charts had to show separate lines for the Electorate of Saxony, the Prince-Bishopric of Augsburg, the Duchy of Brunswick-Lüneburg, and about 1,800 other semi-sovereign states? Can you imagine traveling around if each of them had its own currency? (Fun fact: the List of states in the Holy Roman Empire Wikipedia page doesn’t contain such a list. Instead it points to no less than 28 sub-lists.) Jacobs stops shy of asking, in either book, the question that seems to be the logical continuation of her reasoning: should everything be a city-state? Should we encourage separatism until each inhabited place in the world is either a city or a city region with its own currency? We can hazard a guess as to what her answer would be. She would probably say that there’s no need to upend everything right this moment. Just adopt an attitude of political openness and experimentation. Don’t try to hold together entities that don’t work that well. When separatist sentiment arises somewhere, you can argue it’s a bad idea, but don’t fight it out of emotion such as fear for your nation’s integrity. Eventually, things will settle — the regions that want to be city-states will be, and those that prefer to be united with others, for cultural or economic reasons, will stay that way. Unity has good PR and some genuine advantages, so there will still be plenty of it. But maybe Jane Jacobs never asks this question because she knows it’s irrelevant. We just can’t help fighting for our big countries and supranational unions (like the EU), and too bad if they enter long periods of stagflation until they violently collapse. This might be the right time to mention that her last book, published in 2004, is called Dark Age Ahead. IV. Something to Dislike For Everyone Jane Jacobs’s most famous book is The Death and Life of Great American Cities. She is recognized as perhaps the most influential thinker in urbanism. She is credited with saving Greenwich Village and SoHo in New York City, and helping cancel the Spadina Expressway in Toronto. To this day people organize “Jane’s Walks” as a living memorial to her impact on cities. But Jane Jacobs herself thought that her greatest intellectual contribution was not in city planning, but in economics. She thought that import replacement was her most important discovery, since it explained how wealth expands better than existing macroeconomic theories. She wrote multiple books that were explicitly about economics and was about to write another when she died, Uncovering the Economy. I am not an economist, so I might not be qualified to make a judgment on this matter, but: it seems to me that there’s a discrepancy here. Jacobs is widely seen as a great intellectual, but her economic ideas don’t quite seem mainstream. I’d never heard of import replacement before reading her book. Why not? The null hypothesis is that economists have examined her ideas and simply rejected them. There were some critical academic reviews of Cities and the Wealth of Nations when it came out, and more recently Tyler Cowen expressed his own mild skepticism. Some of the criticism involves the lack of quantitative data in her work, and her failure to think about issues of scale. The most obvious target, of course, is her city obsession: yes, cities are important, but they’re not the only economic phenomenon that matters, some would say. Perhaps Jacobs has overplayed her hand. But there are other possible explanations for the discrepancy. One is that she was a woman and had no credentials, which made it difficult for (mostly male) professionals to take her seriously. We know this was true at the beginning of her career at least. It seems possible that even after she managed to establish herself as an original urban thinker, economists had trouble accepting that she could, with her lack of any college degree, come up with new insights in their field. I doubt that’s really true today, though. We do take Jacobs seriously, and still read all of her books, which is more than we could say about most economists. Instead, I propose that the discrepancy comes from a darker place: in laboring to be comprehensive about cities and economics, she reached conclusions that most people don’t want to be true. No matter your politics, there’ll be something for you to dislike in Jacobs’s work. For example, it’s pretty clear that she didn’t think the European Union was a good idea, so she probably would have supported Brexit. Brexiters might rejoice, except that a lot of them are British nationalists who certainly don’t want Scotland to leave the UK, whereas Jacobs would agree with that. Which would be great news to Scottish independentists — except that if a new separatist movement arose within Scotland, she’d also support that. Jacobs’s ideas and grassroots activism in favor of small-scale, organic urban planning have come to be seen as left-wing — yet her criticism of national welfare programs wouldn’t make her out of place among hardcore right-wingers. Unless those right-wingers were military hawks, in which case they’d find no solace in reading Jacobs on military transactions of decline. Writing during the Cold War, Jacobs criticized the Soviet Union for its incredible centralization of decision-making in Moscow. She rightfully predicted its collapse, making her an ideological ally of the capitalist West, right? Not so, since the United States is also, according to her, too centralized and in the early stages of decay. “Today the Soviet Union and the United States each predicts and anticipates the economic decline of the other,” she writes. “Neither will be disappointed.” Whether she was correct about the US is left as an exercise to the reader. In any case, she did foresee, using her theory on cities, the decline of Japan. This must have been bold in the 1980s at the peak of the Japanese economic miracle, when there was a widespread trope that Japan would soon take over the world. Yet she was right: in 1991, Japan entered its “lost decade,” which soon became two lost decades, and then three. To be fair, she predicted the decline of all large-ish countries, so I wouldn’t mark her as a superforecaster or anything. Still, this puts in perspective the more recent trope that China is going to take over the world. No country, no ideology is safe from Jacobs’s prophecies. Smaller ideologies aren’t spared, either. Effective altruism would probably seem totally mistaken to her, since at its core it promotes an inorganic, top-down transfer of wealth from prosperous cities to poor areas. Progress studies people think that technological innovation will solve economic stagnation, but she would point out how labor-saving equipment so often causes damage when it is introduced to regions that don’t benefit from the other city forces, like the Scottish Highlands or many of her other examples in Colombia, India, or the American South. (This point would deserve an essay of its own, but reading Jacobs has made me a bit more worried about the “AI will take our jobs” thing. It’s clear that new jobs will appear, but when the technology city force from the San Francisco Bay Area reaches distant places with poor economies, which it will very soon thanks to the internet, the effects might not be very pleasant to see.) Overall, the political ideology that might fit Jacobs the best might be… libertarianism? She’s not a big fan of large governments who make big top-down decisions, clearly. Yet I don’t get the feeling that this association fits all that well either. Jacobs doesn’t seem to be anti-government if the government is at the city level. I doubt she would have liked the kind of hyperfragmented world depicted in Snow Crash by Neal Stephenson. I also doubt she’d be impressed by cryptocurrency-backed “cloud cities” or fantasies of charter cities, none of which she would see as real cities in the sense of concentrated pockets of people who start replacing what they import with local production. Jane Jacobs, in sum, was an archetypal accidental moderate. She took one idea very seriously — the idea that cities are fundamental — and explored its ramifications without caring in the slightest if it led to the “wrong” opinions, as her friends in 1980 Toronto must have thought when she wrote about Quebec. I don’t know if she went too far; I’m sure someone more qualified than I am can find flaws in that core idea or any of her other observations. But to me she sounds convincing, and her consistency is frankly admirable. So, to end this review on a more review-y note, go read Jane Jacobs. Her books are a delight, with their elegant arguments and masterfully told anecdotes. Her predictions often take an air of doom, but she is also an optimist who offers constructive ways forward. She sets an example for all of us who care about getting the details right, no matter the credentialed experts, the current political climate, or the great theories of the past. Image credits Cities and the Wealth of Nations book cover: from Amazon.

Inline links: List of states in the Holy Roman Empire, https://substackcdn.com/image/fetch/$s_!gyMq!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fdc388f24-009c-42ee-adca-9d5c50faaa66_932x190.png, academic, reviews, expressed, Japan would soon take over the world, fantasies, of, charter, cities, accidental moderate, https://substackcdn.com/image/fetch/$s_!r8Rb!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F60621c76-b34b-4e10-b272-394480443e1b_1600x1066.png, Amazon

Meetups Everywhere 2023: Times & Places

August 25, 2023 · Original source

EDINBURGH, SCOTLAND, UK Contact: Sam Contact Info: acxedinburgh[at]gmail[dot]com Time: Saturday, September 16th, 2:00 PM Location: The basement of Black Medicine Coffee Company on Nicolson Street Coordinates: https://plus.codes/9C7RWRW7+VJ Group Link: Please email acxedinburgh@gmail.com to join the mailing list. Each month, we run a meetup where we discuss ~three essays, sent out in advance. Please email acxedinburgh@gmail.com to join the mailing list and/or WhatsApp group, and see the September readings.

Inline links: https://plus.codes/9C7RWRW7+VJ, acxedinburgh@gmail.com

ACX Grants Results 2024

February 10, 2024 · Original source

Marcin Kowrygo, $50,000, for the Far Out Initiative. Recently a woman in Scotland was found to be incapable of experiencing any physical or psychological suffering2. Scientists sequenced her genome and found a rare mutation affecting the FAAH-OUT pseudogene, which regulates levels of pain-related neurotransmitters. Marcin and his team are working on pharmacologic and genetic interventions that can imitate her condition. If they succeed, they hope to promote them as painkillers, splice them into farm animals to produce cruelty-free meat, or just give them to everyone all the time and end all suffering in the world forever. They are extremely serious about this.

Inline links: the Far Out Initiative, a woman in Scotland was found, 2

Links For February 2024

February 29, 2024 · Original source

19: Claim: nine people in a family in Scotland have a mutation in the RIMS1 gene, which makes them go blind in their twenties and also apparently adds 20 IQ points. Large single-gene effects on IQ are not supposed to exist, but it’s theoretically possible that a rare mutation with a big downside could do it. I’m still a little skeptical, because this seems trivial enough that evolution should have found a way to do it without the blindness by now. But at least on a superficial reading the paper looks good.

Inline links: a mutation in the RIMS1 gene, not supposed to exist

Your Book Review: The Family That Couldn’t Sleep

July 12, 2024 · Original source

(This report was, as it happens, published in the exact same month as The Family That Couldn’t Sleep.) DTM came to know the family well. He befriended them by way of two members of their younger generation, Lisi – a woman terrified by the shadow of the disease, and Ignazio – the doctor she had married, who was more terrified by the shadow of the disease. Ignazio put together the pieces of the family puzzle, consolidating all the disparate diagnoses into a single disorder and filling out a lot of blank spots on family trees. When DTM came along, he was able to help Ignazio make the case that the family would benefit from the spotlight – that greater awareness of FFI could lead to a cure both for them and for a slew of other prion diseases. As it so happens, he is one of those nonfiction authors who serve as a character in their own story. DTM has some form of progressive muscular palsy. He is, or at least was in 2006, not entirely sure what it is. The relatively unimpressive state of genetics at the time had not identified his causative mutation, though it looked a lot like one of the rarer forms of Charcot-Marie-Tooth disease2. DTM is pragmatic about this, the way everyone chronically ill is either pragmatic or doomed. Whatever he has, it is a defect in protein structure; his peripheral nerves decay not because of a problem with the nerves themselves but an inability of their scaffolding to hold them together, as he puts it. The last chapter of the book dwells on this, on the web of connections popping up between a thousand disorders. DTM’s disease is something vaguely similar, if you squint, to an exceptionally slow-progressing motor neurone disease; if you jump another level out, you see amyloid plaque diseases like Huntington’s and Alzheimer’s, and if you jump yet another level out, you see something like prions. His interest in the Venetian family was driven by this. Some of its members thought this a beautiful act of sympathy; others thought him a grotesque parody of themselves, an onlooker, a gawker, peddling their tragedy to salve his relatively insignificant problems. They are, he thinks, both right. That’s the beginning, and that’s the end. What happens in the middle? --------------------------------------------------------- The Venetian family lends the book its title, but they’re really more of a framing device. The Family That Couldn’t Sleep is separated into four parts, of which the first and fourth – the shortest by far – deal with the family. Part 2 is kuru, the king of fucked up diseases you read about in clickbait Weird Medicine listicles. Let’s talk about kuru! Kuru, is, famously, the prion disease you get if you eat another person’s brain. Well, not quite. It’s a prion disease that became endemic amongst women in the Fore society, who ritually ate brains, one of which had an inherited or spontaneous prion disease. This is an important note – there’s a tendency (which the book’s later chapters engage in) to assume cannibalism just has a Prion Disease Generator attached. If you eat people who don’t have prion diseases, you won’t suddenly get one. Uh, don’t eat people. Anyway, part 2 is DTM’s historiography of Fore-Westerner first contact. It’s hilarious. Papua New Guinea is a frankly ridiculous place; one of the all-time best Lyttle Lytton winners (worst first sentence from a hypothetical or, in this case, real work) was “Papua New Guinea is so violent that more than 820 languages are spoken there”. The native residents were so hostile to outsiders that all the colonial empires had cut their losses – and when you think about the places they colonized, that says something. After the First World War, PNG was ripped from its nominal German ‘owners’, but no one else wanted the place. So, of course, they gave it to the Australians. It was thirty years and another war before we actually made contact. 1940s Australia was as ‘settled’ as it’d ever be; the cities were bustling and the interior was mapped. The kind of explorer who two centuries before would be heading to new continents had to console himself with Pacific islands. Console he did. The native peoples of the PNG coasts were hostile enough to the wannabe-colonialists that the Australians, flying planes overhead, were the first people to discover that the island’s inland was populated too. No one had broken through on land. In all this deep and angry rainforest, the Fore were the furthest out. They lived far into the island’s mountainous interior; DTM describes their territory as “nearly vertical”. Calling people primitives is a bit passe these days for understandable reasons, but no other term comes to mind. The Fore had no name for themselves; we call them by an exonym, “the people to the south”. They weren’t, to be clear, hunter-gatherers – they were slash-and-burn agriculturalists, but very well-fed ones. Despite the tendency in grain-focused cultures for poor agriculturalists to be stunted/malnourished, the Fore were a remarkably healthy people. Well, except for the famous bit. The first remarkable thing about the Fore was just how quickly they wanted to assimilate. Most PNG tribes weren’t particularly enthused by Western offers of injections/tractors/radios/Christianity. Yet as soon as the Australians arrived, the Fore made ceasefires in their wars with other tribes, volunteered to help large-scale Australian projects on the coast, started planting and trading coffee, and enthusiastically participated in censuses. It’s the only first-contact narrative I’ve seen where the colonizers were concerned about how badly the other guys wanted to be colonized. The next was the one that got their names in the history books. Australian officials started to notice a remarkable lack of women in Fore camps. Some tribes sequestered their women, particularly when Westerners were around, so at first they thought nothing of it. The high rate of unpartnered young men, though, was way out of PNG norms. DTM tells this part fantastically. The Fore chapters drip with the dread of dramatic irony. When the first breakthrough comes, you have to catch your breath: “Tiny” Carey noted something in the middle of August 1950 that deepened this mystery. He noticed that near the village of Henganofi there had been an unusual number of deaths. “It appears,” he wrote his superiors, “natives suffer from stomach trouble, get violent shivering, as with the ague, and die fairly rapidly.” [...] McArthur investigated a little more [...] One day in August 1953 he ran into more of the shivering people Tiny Carey had seen several years before: “Nearing one of the dwellings, I observed a small girl sitting down beside a fire. She was shivering violently and her head was jerking spasmodically from side to side.” It would be quite some time before anyone figured out what caused it – but the problem, as DTM notes, was that its cause wasn’t possible. Everyone priored that the weird undescribed disease in the Fore lands was some nocebo sorcery-sickness. Vincent Zigas, the first actual doctor sent to work with the Fore, tried to placebo-effect them and failed miserably: On the way, Apekono stopped at a hut and showed Zigas his first kuru victim. “On the ground in the far corner sat a woman of about thirty,” the doctor wrote. “She looked odd, not ill, rather emaciated, looking up with blank eyes with a mask-like expression. There was an occasional fine tremor of her head and trunk, as if she were shivering from cold, though the day was very warm.” It was almost exactly the tableau McArthur had witnessed in 1953. Zigas, though, was a doctor. He could do more than look—or so he thought: “I decided I might as well try my own variety of magic,” he remembered. He rubbed Sloan’s Liniment, a balm for sore muscles, on her and declared to her family and his guide: “The sorcerer has put a bad spirit inside the woman. I am going to burn this spirit so that it comes out of her and leaves her. You will not see the fire, but she will feel it. The bad spirit will leave her and she will not die.” The lotion penetrated the woman’s skin and she writhed in pain. “Get up! Walk!” Zigas commanded theatrically. “The woman struggled feebly as if to rise, then, exhausted, started to tremble more violently, making a sound of foolish laughter, akin to a titter.” That evening Apekono asked Zigas not to try to cure any more kuru victims; “Don’t use your magic medicine anymore. It will not win our strong sorcery.” This was a disaster. The Fore were so cooperative precisely because they hoped “Western magic” could conquer theirs. As it became clear it couldn’t, they turned hostile. The Australians had hoped to “modernize a Stone Age people”; now all their subjects were dropping dead before their eyes, from what they could only assume was a “hysterical reaction” to colonization itself. So, to solve this, they needed a batshit insane American. Carleton Gajdusek is one of the characters who dominates The Family That Couldn’t Sleep. He couldn’t not. You could put him in a car commercial and he’d dominate it. Gajdusek was a physician with a rare, intense combination of science and practice. He was a romanticist, a field worker, and a lover of everything strange. He’d been an army doctor, a government conspiracy-cover-upper, and a postdoc under Linus Pauling who described his intent as “to straighten out Pauling’s ideas about proteins”. He hated civilization, in a slightly-to-Ted’s-centre sense, and was passionate about “primitives and isolates”. He jumped at the chance to work in Papua New Guinea; he planned to conduct a multi-site study on child development in such cultures, and relished the opportunity to live in a “primitive” environment himself. He did all this so he could rape kids. Oh, he did it for the scientific curiosity and love of medicine, but he also did it so he could rape kids. Gajdusek was a pedophile in the actual-lifelong-exclusive-paraphilia sense, as opposed to the “metonym for child molester” sense. Some people who roll snake-eyes on the Sexuality Dice repress it, but some are perfectly happy to act on it; Gajdusek was #2 in its fullest form, the kind of guy who believes that a well-lived life includes raping some kids. DTM doesn’t shy from this, not for a moment. It’s the first thing he tells you about Gajdusek. It couldn’t not be; you couldn’t talk about why he went to PNG otherwise. When Gajdusek landed in PNG, he first found the place too civilized. He’d been promised a land of “cannibal savages” – where were they? After some traipsing, he found them, right where he was promised. The Fore were perfect for Gajdusek. They had some kind of medical mystery that’d been lost on everyone else. They ate each other, in exactly the way he loved detailing in his diaries (“”Women and children, particularly, partake of the human flesh,” he noted with pleasure”). As kuru cases popped up, he aggressively recorded them. He wrote lovingly detailed notes that he sent back to his Australian advisor. He wrote with intensity, with exclamation marks, with the joie de vivre of a man just where he wanted to be. Gajdusek smothered the Fore with ‘cures’ that never worked, but they didn’t get angry at him. As DTM dryly puts it: “Their children trusted him, and that was enough for them.” At some point, someone suggested sending an anthropologist...or an epidemiologist...or literally anyone with more credentials than Gajdusek and Zigas3. Gajdusek threw a shitfit, convinced this one-and-a-half-man team was enough to Solve The Problem Forever. But he got bored eventually – running off with another tribe with, as his diary notes at length, an apparent custom of youths ritually fellating older men – and Zigas, I dunno, the book neglects him a bit here. So they managed to sneak in some anthropologists. The husband-and-wife team of Robert Glasse and Shirley Lindenbaum4 were the first involved parties to give a shit about the Fore as people, rather than as colonial subjects/medical mysteries/walking sex toys. What they uncovered was fascinating. The Fore were cannibals, yes, but they were recent cannibals. They didn’t have an ancient tradition of eating their dead, like the other visitors assumed. They happened to be in contact with some cannibal groups, and after a Fore man died of “sorcery”, they thought: well, what would happen if we ate him? “People tasting it expressed their approval. ‘”This is sweet,” they said, “What is the matter with us, are we mad? Here is good food and we have neglected to eat it.”” If not for the wild coincidence that the first Fore cannibalism victim had a prion disease, kuru would never have existed. Glasse and Lindenbaum started to put together the pieces. They’d been sent down to rule out a genetic explanation – to track the kinship ties of the Fore and see how the disease ran through families. It didn’t run through families in any coherent sense, but it sure did run through cannibalism. The clincher was the age distribution. The Fore, ever enthused by colonialism, quit eating each other as soon as the Australians arrived. Children stopped dying of kuru shortly after; they simply weren’t exposed to the infectious agent. The couple sent the news to Gajdusek, who was off raping kids somewhere else. In the next part of the book, DTM runs through Gajdusek’s many conjectures of kuru’s cause – more like sketches or abstract paintings than like true hypotheses. Gajdusek was annoyed that someone else was doing something he “totally could’ve done”, and even more annoyed that another lab was running similar experiments – an attempt at a vaccine for a particular sheep disease had accidentally created a prion generator. But he was happy to swoop in and claim the credit for what he was starting to think of as “slow viruses”, an infection that somehow lays dormant for years. DTM portrays Gajdusek perfectly, in that “real life has no need for verisimilitude” way. Gajdusek was at once a brilliant man, an all-consuming narcissist, an entertaining character, and a monster beyond redemption. A lesser book might pick one or two. The Family That Couldn’t Sleep portrays him as all four, and on a personality level (as opposed to a scientific one), the Gajdusek-focused parts are some of the most gripping. --------------------------------------------------------- Outside of the jumps between the Venetian family and everything else, The Family That Couldn’t Sleep is not siloed. The narratives of all prion diseases are deeply intertwined. This is what makes it a great book. It’s 300 pages of dramatic irony. You read the whole thing, waiting for the eureka moment – the point everyone realizes they’re looking at the same cause. It does, however, make it a tad difficult to review or synopsize. The book’s story is so weird – and, often, so at odds with conventional wisdom that trickles down about the Fore et al – that you have to recap quite a bit, and the book steadfastly resists recapping. The next couple chapters after we depart from Gajdusek’s credit-claiming are mostly about experiments with various prion diseases. They’re scientifically fascinating. Unlike some medical-books-for-general-audiences (cough, How Not to Study a Disease), DTM never talks down to the reader. He assumes someone reading a 300-page book about prions is smart and wants to learn about prions. He also has – you can feel it in his words – the agonizing experience of spending his life on the other side of the doctor’s desk, trying to beat into whoever he’s talking to that no, seriously, you don’t need to lie to him or try explain a complex disease at a fourth-grade level. The first prion disease studied was scrapie. Scrapie was a big deal – it starved and killed large shares of British sheep flocks, making it a serious economic problem. Veterinary researchers had tried to prevent or cure it for centuries. It was a veritable graveyard of ambitions: Quintessential was D. R. Wilson at the Moredun Institute in Scotland, who worked in the middle of the last century for more than a decade trying, with mounting frustration, to kill the scrapie agent. He found that it survived desiccation; dosing with chloroform, phenol, and formalin; ultraviolet light; and cooking at 100 degrees centigrade for thirty minutes. The scrapie researcher Alan Dickinson told me he remembered Wilson at the end of his career as “very, very, very quiet. Of course, that was after his breakdown.” “Now it is our turn to study prions. Perhaps we should approach the subject cautiously.” The problem, as DTM explains, is that prion diseases were impossible. They violated 20th-century understandings of biology. Proteins “were no more alive, and no more infectious, than bone”. Prion diseases seemed to have too many causes – genetic, infectious, and sporadic. They looked infection-like in some ways, but patients didn’t produce virus antibodies. Sheep exposed to scrapie, or chimps infected with kuru, took years to develop symptoms. Their facts did not fit together. In the 1960s, people started wondering. The unifying trait of prion agents was that they had to be denatured to be destroyed. Was this a particularly small virus defined by its protein coating? Or – even more outre – was it pure protein, no DNA at all? No one could figure out quite how the latter worked, but it was tempting. Gajdusek, by now a major figure in this field, kept a foot in both worlds. He didn’t want to stake his reputation on a no-DNA hypothesis, but he certainly sympathized. Enter Prusiner. Stanley Prusiner was Gajdusek’s counterpart. Where Gajdusek seemed permanently manic, Prusiner was deliberate and exacting. He entered Gajdusek’s “slow viruses” field in the early 1970s after a chance encounter with a CJD patient. He relished the laboratory in a way Gajdusek didn’t at all, and set out to optimize the hell out of his projects. Prusiner set out to isolate the smallest infectious particle in the scrapie agent. He injected tons of hamsters (hamsters got sick faster than mice) with increasingly tiny scrapie proteins, hoping to determine whether the Minimum Viable Scrapie was DNA. By the mid-1980s, he’d produced something so small it couldn’t possibly be a virus. Denaturing it destroyed it; exposing it to nucleic acid dissolvers actually made it stronger. Emboldened by this discovery, Prusiner set out to anoint himself the King of Prions. Here emerges something of a Voldemort-Umbridge distinction – the difference between cartoonish villainy and banal evil. Gajdusek is a bad guy because he rapes kids. Prusiner is a bad guy because he is the most grotesque stereotype of the Advisor/Peer Reviewer from Hell made flesh. Everything Prusiner did was to build his reputation atop a pile of skulls. When recruited as a peer reviewer for other prion papers, he wrote negative reviews to undermine their authors. He worked his grad students to the bone and intentionally destroyed their careers, telling them he’d “ruin them” if they entered prion research as competitors. He lied about the origin of the protein-only hypothesis, claiming he originated it a decade after it was actually conjectured. But hey, he was good at getting grants. I was surprised reading a lot of this, because for all the time I’ve been aware of it, the cause of prion disease has seemed settled. “Oh yeah, it’s a protein that gets all fucked up.” But DTM goes through just how unsettled it was right up through to The Family That Couldn’t Sleep’s publication. Serious confirmation only arrived a couple years later. Many people were deeply critical of the prion hypothesis – often, it seemed, because they loathed Prusiner too much to go along. Throughout the book, he cuts an uncharismatic figure. Gajdusek and Prusiner both won the Nobel for discovering prions, decades apart. This tells you something – the “discovery” of prions can be construed quite a few ways. Gajdusek formulated the hypothesis; Prusiner proved it. Gajdusek was grievously offended by Prusiner’s Nobel, perceiving his rival – not inaccurately – as a follower who never originated any ideas of his own. But Gajdusek was offended from a federal prison cell, so how’d that work out for him? Fascinating as all this is, no one published a book about prions in the mid-2000s because it was about kuru or FFI. They published books about prions because teenagers were dying, and people wanted to know why. DTM lays the seeds for part 3 – the mad cow section – in part 1. This is a discussion of scrapie, the longstanding prion disease of sheep. Scrapie was a medical mystery for centuries (remember poor D. R. Wilson), precisely because of the intuitive implausibility of prions. The scrapie chapter is a great history-of-science piece, covering the agricultural productivity revolutions of the 18th century, the surfeit of bizarre origins veterinarians concocted, and the treatments that never worked. Scrapie is not transmissible to humans – well, we hope. It’s concerningly transmissible to primates. But it’s been around for a long, long time, and it doesn’t epidemiologically look like humans get it...we hope. Anyway, you ever tried to generalize from one example? The British government did! In the mid-1980s, strange reports started coming out of the UK’s farms. Farmers were describing a new disease where dairy cows – incredibly docile creatures, under normal circumstances – turned hostile, kicking them as they went into the milking stalls. The symptoms looked to all the world like scrapie. Epidemiologists tracing the outbreaks found a unifying link with “cake” – animal protein feed sweetened with molasses. The scrapie-like symptoms must have traced to an infected sheep. But scrapie doesn’t transmit to humans, so it must be okay to keep slaughtering them, right? We all know how this ended. The best term for the British response to the mad cow outbreak is “cacklingly evil conspiracy”. The agricultural industry really, really didn’t need a huge zoonotic outbreak – so it decided it didn’t have one. They first suppressed all mentions that the disease looked like scrapie, then – when this became impossible – hyped up that scrapie doesn’t transmit to humans, so there’s nothing to worry about. The formal name of the disease, “bovine spongiform encephalopathy”, was supposedly chosen to optimize for unfamiliarity – it wouldn’t fit well in a headline. They emphasized, extensively, that there was nothing to worry about. Ever. At some point, people started asking questions. If there was nothing to worry about, why was the agricultural industry panicking so hard? As things became ever more worry-inducing, this turned down ludicrously twisting paths: Meanwhile, the Southwood Working Party and the experts who advised it were learning on the job. They learned, for instance, that the BSE agent entered the animal through the mouth and then followed the digestive tract into the organs that try to filter out infections—the tonsils, the guts, and the spleen—and from there traveled into the peripheral and central nervous system, and finally arrived at the brain. They also learned that pasties, meat pies, and even some baby foods contained tissues from a lot of those organs. So the Southwood Working Party recommended banning these organs, but only from baby food. This started a chain reaction of consumer doubt: if infected cow organs were unsafe for babies, how could they be good for adults? The government then banned offal, as the organs were collectively called, in all human food but gave the industry a grace period to get it out of the feed supply. Then pet food manufacturers began to wonder if what drove cows mad might not also drive dogs, cats, and parrots mad. The feed they sold came from concentrate made of the same sick animals that had previously made up the meat and bone meal farmers used. Their trade group decided to put a similar ban in place—immediately. So for five months it was safer to be a dog than a human in Britain. DTM spends pretty much this whole section of the book making fun of the British government. To be fair, they deserved it. They killed hundreds of kids in agonizing and preventable ways – they could take some ribbing. This is all throughout the mid-1980s to early-mid 1990s. Through this period, it wasn’t yet clear that mad cow could spread to humans. The panic was clear, and deserved, but it didn’t yet have a match for its powder keg. It would alight. The first suspected case of vCJD – human mad cow – was in 1994. Fifteen-year-old Vicky Rimmer developed a sudden, strange disease. Doctors gave her months to live...until she died in 1998. A couple other suspected cases trickled down through the mid-90s, including a young man who made meat pies for a living, whose grieving mother received a letter from the Prime Minister that “humans do NOT get mad cow disease”. (That must’ve been fun.) Soon, they couldn’t deny it any longer. On March 20, 1996, Stephen Dorrell, the health secretary, stood up in Parliament to announce the news that had already appeared as a tentative conclusion in scientific journals and as rumor in newspapers for the previous two years: British beef was killing British teenagers. The first confirmed death was that of Stephen Churchill, a nineteen-year-old student from Wiltshire, who died in May 1995. Back in 1989, at the Southwood Working Party’s suggestion, the government had set up a surveillance unit in Edinburgh to watch for any evidence that BSE had crossed to humans. One worry had been that if BSE passed to humans, how would anyone know it? How would you recognize something you had never seen? It turned out to be easy: Churchill and the nine other teenagers who had gotten sick had spectacular amyloid plaques in their brains, chunks of dead protein almost visible to the naked eye. If sporadic CJD was a whisper, BSE-caused prion disease was a shout. The investigators sat open-mouthed looking at slides whose damage, they feared, portended the most severe epidemic in modern British history. This part of the book is not fun. It lacks the insane personalities and duelling careers of the other entries. It is an honest chronology of the vCJD epidemic – a gruesome failure of the agricultural industry, the one system that everyone is vulnerable to. The government and industry had completely violated their duty of care to citizens and consumers. They were paying the price. No one would buy British beef anymore – not while they watched their children die. Now here’s the thing: this is ethnography, not historiography. The Family That Couldn’t Sleep is a book from the mid-2000s. The epidemic was not at all in the rear view mirror. There were piles of unanswered questions that DTM constantly alludes to. We have eighteen years more hindsight than he did then. What do we know now? --------------------------------------------------------- In 2006, the vCJD epidemic looked like it was going to be a lot better than the worst fears. BSE itself was a huge problem for the cattle industry, but honestly, no one is too sympathetic to the cattle industry. People were not going to die in anywhere near the numbers believed. We had all sorts of reassuring data coming out about this, which DTM chronicles. We were learning that only some genotypes seemed susceptible to vCJD. We didn’t see any older people die of the disease. We were seeing numbers drop, such that vCJD must have a pretty short incubation period. Anyway, all of this is wrong! The Family That Couldn’t Sleep was written in the candidate gene era. Back then, the nascent field of human genetics was sure it was about to Solve Polygenism. Yes, the simple Mendelian monogenic patterns popular a few decades back clearly didn’t apply to common diseases, but how many variants could there be? We were about to discover the five genes influencing 20% of Alzheimer’s risk each, the five genes influencing 20% of heart disease risk each, etc., and once we were done we’d just do gene therapy and cure Alzheimer’s. A paper on autism genetics from 1999 was so outre as to speculate there might be as many as fifteen genes involved. The fact we are now using the term “omnigenic model” should tell you roughly how well this worked out. Do you remember SNPedia? If you were a 2014 Slate Star Codex reader, you might. 2014 was still pretty candidate gene. People were out there publishing papers saying a single variant could increase your life expectancy by 15 years. SNPedia was a site that beautifully categorized all of these, so you could do 23andme or whatever, look up your results on SNPedia, and make horrible life choices.5 It was eventually bought out by one of the consumer DNA companies, so no one ever edited it again, making it a great time capsule of early-mid 2010s behavioural/medical genetics takes. SNPedia will excitedly explain to you that common genetic variants make you immune to vCJD. They cite a 2009 post from the now-archived 23andme blog titled “No Good Evidence That Potential Pool of Mad Cow Disease Victims Is Expanding”, explaining how fears of late-onset vCJD are clearly debunked by new Scientific Knowledge. Everyone who developed vCJD in the 1990s and 2000s had an M/M genotype in a particular part of the PRNP prion gene, so the roughly half the population with M/V or V/V genotypes were immune. The Family That Couldn’t Sleep buys this, too. In fact, it buys it in an even more agonizingly 2000s way. The first sign that transmissible prion diseases weren’t genotype-restricted should’ve been the growth hormone kids. You might have heard this story – from the late 1950s through mid-1980s, human growth hormone produced from brain tissue was used as a treatment for pituitary dwarfism, until it turned out to spread CJD if the originating brain was infected. DTM discusses this, to set the scene for the genetics thing. He mentions what was the state of the art at the time – that a disproportionate share of both the growth hormone kids and sporadic CJD cases were V/V homozygotes. This, uh – so the book was written in the mid-2000s, yeah? Yeah. The conclusion DTM drew – and this was a common conclusion at the time – was that homozygosity somehow made you more vulnerable to CJD, and M/M homozygosity made you vulnerable to BSE-borne CJD in particular. We cannot criticise the author for not predicting the future, but we live in the future, and can say how this worked out. Turns out, nope, M/V heterozygotes totally get vCJD. After a British man in his 30s died of CJD in 2016, he was found to have vCJD and an M/V genotype. He was tested for vCJD only because he was exceptionally young for someone with a sporadic prion disease – meaning people developing it later in life would be missed6. Did you know up to 1 in 2000 people in the UK have latent vCJD? There is one line in The Family That Couldn’t Sleep that stopped me dead in my tracks when I read it: What happens to the Italian family in the end depends less on their own actions than on the world’s interest in prion diseases, which they cannot control. If lots of people are afraid of getting variant CJD, the family benefits. If fear of prion disease goes the way of the fear of swine flu or Ebola, then they will be orphaned again. THIS BOOK IS FROM 2006! Three years before the swine flu pandemic! Eight years before the Ebola pandemic! “If you’re looking for a sign, this is it.” --------------------------------------------------------- The last section of The Family That Couldn’t Sleep addresses BSE fears in America and a nascent internet subculture DTM calls “Creutzfeldt Jakobins” – people who track American CJD cases, trying to spot vCJD patterns. When reading his description of the Creutzfeldt Jakobins, my mind constantly, uncontrollably turned to covid. Here it was – an online community of people deeply skeptical about a disease’s official story, tracking every contradiction, every implausibility, every statistic that failed to apply to the individual. Self-described “redneck hippies” and “soccer mom Republicans” teaming up to find the truth hidden behind an impossible world. You know what they’re doing now. I’ve always combined a deep interest in medicine with a healthy distrust for it. People who are constitutionally inquisitive, anti-authoritarian, and suspicious about official narratives tend to end up skeptical of at least some mainstream claims in the field. This is not to say I think you should take bleach enemas or something, just that I understand the impulse behind concluding the US government was covering up a local vCJD wave. Traditionally, sporadic prion diseases are said to have a prevalence of one in a million. (Hold on to that for a second.) The last section of the book is a chronology of Americans finding bizarrely more than one in a million of their friends dying of sporadic CJD, often at inexplicably young ages, sometimes in geographical clusters. This is understandably suspicious. Then DTM goes on to reassure us by saying none of these cases were confirmed to have an M/M genotype, which OH GOD OH FUCK A number of high-profile people in the prion world, including Gajdusek, are clarified as not believing sporadic prion diseases exist. You get the impression DTM doesn’t, either. Now, how common are prion diseases? Eric Vallabh Minikel has an answer for you! Eric and his wife Sonia are prion researchers from a rather unique background – after Sonia was diagnosed as having a single-gene mutation with ~100% penetrance for prion disease, they left their previous jobs to dedicate their lives to curing it. It turns out, when you run the numbers, you get not one in a million but 1 in 5000 people dying of prion diseases. This is best described as “nightmarishly high”. I’m normed on genetic disorders. A genetic disorder that affects one in five thousand people is pretty common! I have known, in person, completely unselected, just from “random people I’ve met in my life in a non-medical context”, someone with a ~1/250k syndrome and someone with a ~1/50k-100k syndrome. I don’t think anyone in my extended family knows someone who died of a prion disease. I feel like it would’ve come up if they did! Prion diseases have distinctive phenotypes. Not distinctive enough, apparently, to avoid a lot of CJD being misdiagnosed as Alzheimer’s – but diagnosis is consistently insane. Something DTM reiterates throughout The Family That Couldn’t Sleep is just what prion dementia looks like. The characteristic dementia in prion diseases spares something – “self” or “recognition” or “reflection” – that is not spared by Alzheimer’s, or by most common dementias. Shouldn’t this be, uh, noticeable?7 They kill rapidly, often over the course of months, and often onset in midlife. ALS shares this pattern and is way, way more common than prion diseases; you hear about ALS far more in the “disorder people actually have” sense. What am I missing here? Anyway: 1 in 2000 prevalence of latent vCJD in the UK + extreme lack of clarity over whether scrapie is human-transmissible + blood donations spread vCJD + sporadic CJD prevalence keeps going up = ??? (Yes, I am annoyed that most countries have lifted their ban on UK blood donors, thank you for asking!) --------------------------------------------------------- But back to the book. The “American chapter” is one-third about the country’s response to vCJD, one-third about the Creutzfeldt Jakobins, and one-third about chronic wasting disease. The last part is the most interesting. Chronic wasting disease is a prion disease of deer. Like scrapie, it “probably, we hope” isn’t human-transmissible (eat venison at your own risk). Under natural circumstances, deer shouldn’t get prion diseases: A prion plague should not be possible among ruminants in the wild. Deer are not cannibals, as the cows that spread BSE were forced to be; and, because deer and elk are not domesticated, they do not have enough contact with one another to spread a prion infection the way sheep are thought to spread scrapie. But deer do not live as they used to live, humans having once again brought their ambitions to bear on the natural course of things. The Family That Couldn’t Sleep is a book of medical anthropology. Anthropology of the Veneto, anthropology of Papua New Guinea, anthropology of 1990s Britain. Here, it is an anthropology of America. Americans, having won the world, still fight to win their own backyard. The North American continent is geographically diverse, cutting through rain-snow-shine, mountains jutting over plains, cities sprawling into wilderness, habitations criss-cross dotted with surprisingly few empty zones. Go somewhere like Denver, the Mile High City, three million people fighting against nature. Few other countries have anything like this; geographically vast polities usually have uninhabitable blocks. Australians are twenty-five million people clustered against the shore. It still surprises me, after all this time, how every US state has a meaningful city8. Midcentury Denver, growing and sprawling out across its mountains, started to run into their natural inhabitants – deer. Starvation is one way nature adjusts the deer population to the available food supply. People did not usually see this process, but in the 1950s and 1960s Colorado became more densely settled, reducing forested areas and forcing deer to look longer and harder for food. At the same time, the state enacted conservation laws, limiting when and where hunters could shoot. Soon emaciated deer began wandering onto the lawns and through suburban streets looking for a meal. People began to feed them, only to find that they died anyway. They would drop dead by haystacks, along highways, and in flower beds. In the late 1960s, a young biologist named Gene Schoonveld tried to figure out why the deer starved even when they were fed.9 He deprived some deer of food for a while, “[h]e cut windows in their stomachs to see what went on inside, and then he began to feed them”. While this was going on, he had a control group of healthy, well-fed deer as backups in case anything went wrong. It did...but not to the experimental group. The pen in which the deer were kept also housed sheep, which, it turned out, were scrapie carriers. The deer somehow acquired scrapie – there’s a huge unanswered question here, which DTM doesn’t address. How did they get scrapie? They didn’t eat the sheep, presumably. Did it somehow transmit from casual contact? This is not supposed to happen. And yet: the deer in the sheep pen started dying of a mysterious scrapie-like disease, one never reported before, that would go on to infect thousands. These deer were released into the wild. Ten years later, the first reports of chronic wasting disease came out. The disease spread across deer and elk in the western half of the country. By the turn of the millennium, cases were exploding – and lost all geographical restriction. DTM can report up to 2005, at which point it was floating around Upstate New York. This kind of spread doesn’t track natural deer migration. That’s irrelevant, because nothing about CWD’s spread is natural. We shift gears into an anthropology of the American hunter. The hunter wants to shoot the most impressive buck, to bag himself one with as many “points” as possible – one whose antlers branch out most. A “ten-point buck” has five branches on each horn: Original by Ric McArthur Nature doesn’t make enough bucks with perfectly symmetrical ten-point horns. To fill the demand, the market had to step in. Thus was born the deer farm industry, which raises captive deer in better genetic and nutritional conditions than Nature permits, then ships them across the country so hunters who couldn’t get legit ten-point bucks get the taxidermy piece for their wall. These are controversial amongst hunters and illegal in numerous states – but the industry is big enough to spread CWD. (The kind of hunter who needs a deer shipped to his house is the kind of hunter who will fumble killing it.) Another problem is supplemental feeding – leaving out protein-enriched food for deer to eat. This produces “trophy class animals at an earlier age”, but again, what’s in that protein? (“It is much like feeding your cows 41 percent protein cottonseed cake during the winter to raise the protein level in the cow’s diet to a level that will maintain acceptable production”, says that article from 1991.)10 The book segues into a vignette. CWD was new in Wisconsin in the early 2000s, and the state’s Department of Natural Resources was optimistic it could eradicate it. In a state with a love of hunting, you could, in theory, recruit people to kill every single deer in a 400-square-mile radius: In many states, the state would have had to call out the National Guard for such an onslaught, but hunting is a passion in Wisconsin. Hunters shoot 450,000 deer every year, more than in any other state. “I’m looking for ardent hunters to help us, unless fear or their wives keep them away,” one DNR official told a Milwaukee magazine. The state extended the normal hunting season and waived the usual limit of one buck per hunter, and the hunters came out in force. The whole affair was gruesome – one official called it “hunting for slob hunters”. If you’re trying to eradicate a prion disease, you can’t very well let people take the carcasses home to eat. Bodies piled up in control stations, decomposition mingling with bleach. The 2002 hunt established a base rate of 2% for chronic wasting disease in Wisconsin deer, with the most affected areas getting up to 10%. Further hunts in 2003, 2004, and 2005 spread to wider and wider areas – and didn’t move the needle one bit. This is to say that CWD is quite a bit more common in the American deer population than BSE ever was in British cattle. Since publication, it’s popped up in Norway and South Korea. Notably, Norway doesn’t allow for the import of cervids, raising numerous questions about how it got there. There are no unambiguous cases of CWD transmission to humans, and in vivo/in vitro primate studies have mixed results. There sure are some unusually young hunters with sporadic CJD, though. But don’t worry, most of them aren’t M/M homozygotes! There is an absolute ton going on in this book. I’ve had to skim over whole sections. Parts that couldn’t be easily slotted into a narrative review include: When Gajdusek was invited to a party at Prusiner’s house, he was horrified to find his rival had purchased hundreds of New Guinean statues – all with the genitals removed.

Inline links: 2, Lyttle Lytton, 3, 4, a couple years later, concerningly transmissible to primates, omnigenic model, you might, 5, SNPedia, a 2009 post, https://substackcdn.com/image/fetch/$s_!N93S!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fced2eca3-ec58-40b8-8c13-debdb559ab8f_651x601.png, Yeah., nope, M/V heterozygotes totally get vCJD, 6, up to 1 in 2000 people in the UK have latent vCJD, bleach enemas, has an answer for you, 7, blood donations spread vCJD, going, up, 8, 9, not supposed to happen, https://substackcdn.com/image/fetch/$s_!0J8B!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F2a64b287-a7c6-4d82-bbe1-da949fc93118_1024x683.png, Ric McArthur, controversial, amongst, hunters, illegal in numerous states, trophy class animals at an earlier age, 10, Norway, South Korea, mixed results, sure are

Altruism And Vitalism As Fellow Travelers

August 06, 2024 · Original source

Here I’ll also refer back to my old post on Jo Cameron, a Scottish woman with a rare genetic mutation that makes it impossible for her to suffer. She cannot feel pain, anxiety, fear, or any other negative emotion. As far as anyone can tell, she is completely normal. She is a successful wife, mother, and teacher, generally considered well-liked and excellent at her job. She may not have achieved greatness, but I once talked to someone impressive who you’ve probably heard of (I don’t have permission to share their name) who seems to have a lesser version of the same condition.

Inline links: Jo Cameron

H5N1: Much More Than You Wanted To Know

January 01, 2025 · Original source

From “Genesis and pathogenesis of the 1918 pandemic H1N1 influenza A virus”, linked above. You may recognize the lead author - Michael Worobey has also been a leading voice on the zoonotic side of the COVID origins debate. The recent history of the flu, as far as I can tell, is: 1918: An H1N1 flu (“Spanish flu”) jumped from birds to humans in America and killed 50 million people worldwide. This replaced all older strains, so most seasonal flus during this era were H1N1. 1957: An H2N2 flu (“Asian flu”) crossed from birds to humans in China, and killed about 2 million people worldwide. It replaced the H1N1 strain, so most seasonal flus during this era were H2N2. 1968: An H3N2 flu (“Hong Kong flu”) crossed from pigs (?) to humans in Hong Kong, and killed another 2 million people worldwide. It replaced the H2N2 strain, so most seasonal flus during this era were H3N2. 1977: An H1N1 flu (“Russian flu”) leaked from a biology lab (?) in Russia (it might have been a strain from the 1940s, which the Russians were trying to make a vaccine for). It didn’t kill that many people, but it stuck around, and from then on, seasonal flus could be either H3N2 or H1N1. 2009: An H1N1 flu (“Mexican flu” until the PC police stepped in; afterwards “swine flu”) took some horrible circuitous route between birds and pigs and back again, crossed over into humans in Mexico, and killed 200,000 people. It outcompeted older strains of H1N1, but couldn’t crowd out H3N2, so seasonal flus are still either H3N2 or H1N1. …which brings us to the present, hopefully illuminating why “new flu strain crosses over from animals into humans” is such an “uh oh” moment. The Bird Flu Technically, all pandemic flus start as bird flus. Influenza A evolved in birds. Sometimes it spreads to other animals, including pigs, cattle, and humans. The most common way for a bird flu to spread to humans is to “reassort” (not exactly virus sex, but close enough, and the real version is less memorable) with a human flu virus (ie one that has already crossed over to humans). The resulting virus has all of the human flu virus’ human adaptations, but borrows enough new antigens from the bird virus to evade the immune system. Pigs can be infected by both human and bird viruses, so they are a common place for this reassortment to take place. If reassortment is sort of like viral sex, pigs are sort of like Tinder. When a bird flu and human flu reassort in pigs, the resulting disease is called a swine flu. At least the 2009 flu pandemic was a swine flu, and a minority opinion thinks the 1918 pandemic was too. There aren’t major epidemiological differences between direct-from-bird flus and swine flus. H5N1 was first noticed in birds - specifically, a flock of chickens in Scotland in 1959 - after which it disappeared for forty years. In 1996, it showed up in geese in China, then gradually increased its market share among birds worldwide. In 2022, it was found in minks; apparently it had learned to infect mammals. By early 2024, it was seen in cows. Now it’s in cow herds in 16 states, and one of them (California) has declared a state of emergency. And in October, H5N1 was found in pigs for the first time. It’s not uncommon for humans to catch an animal disease. This doesn’t mean the disease has “crossed over” to humans. If the virus isn’t suited to human-to-human transmission, it simply dies off (either before or after killing its human host). Thus, chicken farmers have been reporting scattered H5N1 cases since 1997; now that the virus has spread to cattle, cow farmers have started reporting the same. A Metaculus comment on this topic introduced me to the phrase “biocomputational surface”. Every viral replication that takes place in a human gives the virus one more chance to develop the set of mutations that makes it human-transmissible and start the next pandemic. Or, more likely, every viral replication that takes place in a human who has both the H5N1 bird flu and a normal human flu - or in a pig which has both viruses - gives the virus one extra chance to reassort in a way that produces a bird-antigen-fortified human-adapted flu virus. This doesn’t mean H5N1 will definitely become human-transmissible soon. Many viruses hang out on the borders of transmissibility for decades. Some, for unclear reasons, never cross over at all. But all of this is compatible with the virus becoming transmissible soon. So: What Is The Chance Of A Pandemic? The prediction markets on this topic ask a question about “10,000 cases in the United States”. Does this necessarily mean “pandemic”? Might it be possible to get to 10,000 cases just from the scattered chicken and cow farmers, with no human-to-human transmission? Despite many chicken and cow infections this year, there have only been 60 - 70 recorded human cases. Unless there is a phase change in screening methods, it seems hard for this number to increase to 10,000 off farmers alone. I think it’s fair to treat this question as operationalizing “what is the chance of a pandemic”? By this definition, Manifold estimates a 40% chance of an H5N1 pandemic in 2025. Metaculus estimates a 5% chance. You can see below whether that’s changed since I wrote this essay: 5% versus 40% is a big difference! Who do we trust? I trust Metaculus. Metaculus has beaten Manifold in both of the two head-to-head comparisons that I know of (Jeremiah Johnson’s and mine). Manifold’s number swings by a factor of two from week to week; Metaculus has been steady. But also, Metaculus hosts a CDC-sponsored respiratory disease forecasting tournament which has enriched them in epidemiological expertise. And if you look at the quality of comments on both sites, it’s pretty obvious where the people with more intellectual chops are hanging out. The Manifold comments are mostly single sentences, or occasionally just links to an article about new cases. The Metaculus comments look more like this one by dimaklenchin: Despite the panic propaganda, H5N1 is unlikely to be "just a single mutation away from switching host preference": 1) It normally takes a lot more than a single mutation to switch hosts. E.g., there are at least five different reasons why SIV (monkey equivalent of HIV) is not infectious to humans. Heck, a variant of SIV that bears HIV's receptor-recognizing surface protein (SHIV) is still not infectious to humans. HIV most certainly evolved from SIV but, almost as certainly, it took a very long time to get there. Not that all viruses are the same and things can't turn out differently with flu, but I don't subscribe to the idea that a mere change of receptor specificity (something that can take 1-2 mutations) will be sufficient. 2) We have data. Lots of human infections with other varieties of bird flu in the past - all those viruses ultimately went nowhere. Why would H5N1 be radically different? E.g., the "Canadian teen", despite what sounds like a prolonged exposure, failed to infect anyone around him. Since I am at 18% for the h-2-h H5N1 detection in 2025, I am arbitrarily going ~ an order of magnitude lower than that for something as unprecedented as 10K human infections. Maybe should be much lower but hedging for the time being and will allow another couple months of observations. And Sergio: I'm currently at 20% on the question of reported human-to-human transmission of highly pathogenic avian influenza H5N1 globally before 2026. However, this question is only about the US, and is more general about all subtypes of H5. But H5N1 very strongly appears to be the most important subtype to consider in this time period. And, given the current situation in the US with H5N1 human cases derived from exposure to poultry or cattle (with cattle(mammals) being more worrisome), h2h transmission seems quite more likely to arise in North America than elsewhere before 2026. Conditioning on h2h transmission in the US (and also trying to consider, with lower probability, a start in Canada), I want to estimate the chances that it becomes sustained and out of control (in which case, if it starts in Canada, I largely expect it to spread to the US). The (6) past events of probable h2h transmission of avian H5(N1), none of which were sustained, could serve as a base rate, although I'm a bit wary of giving much weight to this precedent, since the last event was quite a while ago (2007), and also because reporting and testing standards may have improved considerably since then (so perhaps they might not have been classified as h2h transmission events if they had occurred more recently). The current situation in the US, and events such as the Canadian teen who got sick with H5N1, do suggest a higher background level of risk than normal (which would be reduced if a vaccine for cattle is licensed soon), but I'm wary of overupdating. Conditioned on sustained h2h transmission, reaching over 10k cases in a few months seems likely, although perhaps very strong monitoring and surveillance could contain the situation in time (at the very least to moderate the growth rate). Trying to combine all these factors somewhat haphazardly, I'm currently at 3.5% for this question. That’s before 2026. What about longer-term? Manifold gives a ~50% chance before 2030; Metaculus uses a more complicated method but it says about 25% chance before 2030. H5N1 may cross to humans, but it could take a while. Superforecaster Juan Cambeiro at The Institute For Progress estimated a 4% chance of a “worse than COVID” H5N1 pandemic in “the next year”, but their estimate was made in 2023, without the benefit of the Metaculus estimates or most of our current knowledge. This feels high now - Metaculus says 5% total for H5N1 pandemic, and most pandemic flus are not worse than COVID. IFP also seem to be expecting a case fatality rate greater than 10%, which I find unlikely for the reasons mentioned above. I trust their estimate less than Metaculus’ current ones. I conclude that the most plausible estimate for the chance of an H5N1 pandemic in the next year is 5%. Interestingly, 5% is about the base rate for pandemic flus per year: five in the past century = one per twenty years = 5% chance per year. Isn’t it surprising that we’re still at the base rate when we can see a dangerous-looking flu virus spreading through the types of animals that have caused pandemic flus in the past? Part of the answer is that we’re not - in addition to the 5% chance of H5N1, we have to add the chance of some other pandemic flu. This probably isn’t 5% on its own; scientists monitor flu strains closely, and they haven’t found any others which are giving off as many red flags as H5N1. Still, something could always come out of left field. Maybe we should add a 2.5% chance of some other strain, for a total of 7.5% chance of a flu pandemic (ie beyond normal seasonal flu) next year. But still, isn’t it surprising that we’re so close to the base rate? One way to think about this: the base rate represents how concerned we should be if there was no epidemiological monitoring at all. In that case, we would estimate a probability distribution across different epidemiological landscapes, most of which contain some concerning-looking flu strains. Since we are doing the epidemiological monitoring, we can collapse that distribution into a single picture: one flu strain, H5N1, is in fact pretty concerning, and other strains mostly aren’t. This is enough to move our prior from 5% to 7.5%, but no more. The forecasters I talked to raised one other point of uncertainty: does the flu work more like a dice roll, or like a bus? Dice rolls are uncorrelated with their predecessors; even if it’s been a hundred rolls since you last rolled a 6, your chance this time is still 1/6. But buses come at fixed intervals; if the buses are hourly, and you haven’t seen a bus in the past 59 minutes, then your chance of seeing a bus in the next minute is very high. It’s been 16 years since the last flu pandemic; these pandemics come (on average) every 20 years. I don’t think anyone has a good sense of how to think about this. But it was 40 years between the Spanish and Hong Kong flus, so the twenty year number is at best a rule of thumb. The 5% number feels very low to me (and, apparently, to the average Manifold forecaster). Isn’t H5N1 spreading to cows and pigs and all sorts of other mammals? Isn’t it in the news all the time? I trust Metaculus a lot, but I agree that this is a surprising update, and I’m taking it on faith rather than feeling it in my bones. What Would The Fatality Rate Be For An H5N1 Pandemic? There are four basic stories you could tell about likely H5N1 mortality. First, maybe mortality would be 50%. The argument here is that official statistics report this mortality rate in the chicken farmers who have been infected with H5N1 so far. Several news sources and even some scientists have raised the specter of a pandemic version of H5N1 pandemic with this same death rate, which could kill a quarter to a third of the world population. THIS IS EXTREMELY FAKE. The official statistics only report fatality rate in the infections we know about. Bird flu is rare, there’s no mass testing, and we only learn that somebody had it if they’re in a hospital and the doctors are worried enough to test for rare conditions. Of Americans who got bird flu in the past year, 0 out of 61 have died. Probably this is mostly because America upped its detection game and is now finding milder cases; we also can’t rule out the virus mutating to become less virulent. Metaculus estimates the current true mortality rate as 1.25%. …but leaves a wide 90% confidence interval, from 0.5% to 7%. Second, maybe mortality would be somewhere around 1.25%. The argument here is that Metaculus uses this as its central estimate of US mortality. But Sentinel discusses some reasons to be skeptical of broad inferences from the US numbers: Scientists have been puzzled by the apparently low H5N1 case fatality rate in humans in the US. They offer a number of hypotheses: “The way in which the virus is being transmitted — along with the amount of virus exposure — is limiting the severity of disease.”

Inline links: was found in pigs, Jeremiah Johnson’s, mine, a CDC-sponsored respiratory disease forecasting tournament, dimaklenchin, Sergio, reported human-to-human transmission of highly pathogenic avian influenza H5N1 globally before 2026, human cases, past events, vaccine for cattle is licensed soon, https://substackcdn.com/image/fetch/$s_!fL7J!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fd6a70fa6-b356-422d-ba9a-5db431e5a056_751x471.png, The Institute For Progress estimated, news, sources, scientists, Sentinel discusses

Highlights From The Comments On Missing Heritability

July 03, 2025 · Original source

Second, the Scotland pedigree estimates he cites are likely biased due to pop strat. In the RDR paper, @alextisyoung tests a method called “Kinship FE”. At a high-level, Kinship FE estimates heritability using a pedigree model which accounts for shared nuclear family environment. Importantly, this method is quite similar to the methods employed in the two Scotland papers cited by Alexander: Hill et al and Marioni et al (both estimate heritability using pedigrees while modeling the effects of the shared nuclear family environment). Using simulations, Dr. Young shows that Kinship FE is biased in the presence of genetic nurture or pop strat. This is because these processes induce correlations between genes and env beyond the nuclear family. Unfortunately, pop strat bias is not mitigated by PC adjustments. So the key question is: are these at play for cognitive phenotypes? The answer is maybe for genetic nurture & yes for pop strat. Tan et al Figure 1 shows that pop strat biases estimation of genetic effects for IQ & edu. Thus, pedigree estimates should be interpreted w/caution.

Your Review: Joan of Arc

August 01, 2025 · Original source

This produced a succession crisis. The two available candidates to succeed him were the Duke of Guyenne, son of Philip the Fair's daughter Isabella,9 and the Count of Orleans, son of Philip the Fair's brother Charles of Valois. Since the Duke of Guyenne was Edward III, King of England, and the Count of Orleans wasn't, the choice was obvious and France declared that the law had always been that the throne could never pass through a woman. Edward III was sixteen, in England, and busy, so he raised no meaningful objection, and Philip of Valois, called "The Fortunate" because he got to be king, inherited. Twelve years later, Philip eyed Guyenne, the last bit of France left in English hands from Eleanor of Aquitaine’s inheritance, and, observing the English busy in Scotland, he made his move.

Inline links: 9

This was unwise. It had been a reasonable decision to attack Edward II, inept, oppressive, and so devoted to his favorites his lords had plotted his murder; Edward III took after his grandfathers on both sides, conquerors both, and what he had been busy with during his French grandfather’s death was plotting a coup against his regents. At age seventeen he imprisoned his mother, murdered her lover10 and invaded Scotland. After a decade or so the Scots wars pulled the French in - the Auld Alliance was not so Auld back then but it existed - and since the French wanted to get Guyenne back, why not?

Inline links: 10

At that point the dominoes fell fast. The Armagnacs, under the (exceedingly poor) leadership of the Dauphin Charles and his (exceedingly inept) advisors, now the rump state of France, tried to fight multiple times; they called on Scotland for aid and got it and called on Castille and didn't.26 Every time they tried to fight they were beaten and Henry (now "The Conqueror") rolled down France, taking castles one by one and installing loyal members of the Burgundian party - now the collaborators' party - as governors. It looked as though the Hundred Years' War would soon be over.

Inline links: 26

The Fatima Sun Miracle: Much More Than You Wanted To Know

October 01, 2025 · Original source

There’s a joke about three mathematicians who spot a black cow on a train ride through Scotland. One of them says “I see the cows in Scotland are black”.

The second objects “Technically, we only know that there is one black cow in Scotland.”

The third objects “Technically, we only know that there is one cow in Scotland, at least one side of which is black.”

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