Singapore

Article

Singapore is a recurring place in the Astral Codex Ten archive, appearing 33 times across 33 issues between April 14, 2021 and April 01, 2026. The archive places it in contexts such as “similar stories about the success of Hong Kong and Singapore”; “list of Best Practice Peer Countries including: Singapore”; “and less than 1% the size of Singapore”. It most often appears alongside Hong Kong, China, France.

Metadata

Category: Places
Mention count: 33
Issue count: 33
First seen: April 14, 2021
Last seen: April 01, 2026

Appears In

- Hong Kong (16 shared issues)
- China (15 shared issues)
- France (15 shared issues)
- Germany (15 shared issues)
- Japan (15 shared issues)
- India (14 shared issues)
- Canada (13 shared issues)
- Spain (13 shared issues)
- United States (13 shared issues)
- Australia (12 shared issues)
- Boston (12 shared issues)
- Europe (12 shared issues)

External Links

Source Context

Recovered passages from the original issue text. When the raw archive preserved outbound links inside the source passage, they are listed directly under the quote.

Prospectus On Próspera

April 14, 2021 · Original source

You could tell similar stories about the success of Hong Kong and Singapore, two other polities with little to recommend themselves other than a different and more competent regime than the surrounding regions.

The idea behind charter cities is: Shenzhen, Dubai, Hong Kong, Singapore, and the rest of the rich world aren’t rich because their citizens are morally superior to those of their poorer neighbors. They’re rich because they have better legal systems, less corruption, stronger rule of law, and more competent administrators.

Australia, Austria, Belgium, Canada, Chile, Denmark, Dubai, Estonia, Finland, France, Germany, Iceland, Ireland, Hong Kong, Israel, Italy, Japan, South Korea, Luxembourg, Mexico, Netherlands, New Zealand, Norway, Poland, Spain, Sweden, Singapore, Switzerland, United Kingdom, and United States of America

Book Review: How Asia Works

June 28, 2021 · Original source

Not every rich country gets rich by manufacturing. Studwell divides successful countries into three groups. First, small financial hubs, like Singapore, Dubai, or Switzerland. This is good work if you can get it, but it really only works for one small country per region; you can't have all of China be "a financial hub". In the 1980s, everyone was so impressed with Singapore and Hong Kong that they became the go-to models for development, and people incorrectly recommended liberal free market policies as the solution to everything. But the Singapore/Hong Kong model doesn't necessarily work for bigger countries, and most of the good financial hub niches are already filled by now.

He doesn't have as clear an argument against geographic, biological, and cultural factors. Minus a sea or two, Japan, Taiwan, Korea, and China are basically contiguous. It seems weird that all the countries with good policies would be right next to each other. Also, is it just a coincidence that Chinese / East Asian people in Malaysia and Singapore (and now the US) are known for being especially smart, rich, and good with money? Just a coincidence that these areas have hosted some of history's greatest and richest civilizations? Don't these push more in favor of the geographical/biological/cultural theories?

South-east Asia (like India) is a region in which serious land reform is off the political agenda, even if the farce that is the Philippine reform programme continues. Given this, can the Philippines, Indonesia, Malaysia and Thailand do anything else to improve their economic performance? Most obviously they could make the Association of South-East Asian Nations (ASEAN) work as a vehicle for effective industrial policy. There is no reason why the four core economies of ASEAN (and indeed Vietnam, the important economy omitted from this book) could not run an effective manufacturing infant industry policy in what is a market of 500 million people. But there is no sign of this happening. Rather than raising barriers and promoting exports to nurture local manufacturing enterprise, ASEAN is engaged in signing free trade agreements with industrially more developed states, including China. There is very little cohesion, or substantive dialogue, between the political leaders of the Philippines, Indonesia, Malaysia, Thailand and Vietnam. And the considerable influence of the offshore financial centre of Singapore in ASEAN is developmentally deeply unhelpful. It is as if Switzerland or Monaco had been granted a seat at the table when post-war European industrial policy was being planned in the 1950s. South-east Asia remains a beacon for what not to do if you want economic transformation. Allow landlordism and scale farming despite the presence of vast numbers of underemployed peasants capable of growing more. Do not worry too much about export-oriented manufacturing, which can happily be undertaken by multinational enterprises. Leave entrepreneurs to their own devices. And proceed quickly to deregulated banking, stock markets and international capital flows, the true symbols of a modern state. That is how its politicians constructed the south-east Asian region’s relative failure.

Highlights From The Comments On "How Asia Works"

July 01, 2021 · Original source

Another thing: the importance of export markets. These countries need to have markets willing to purchase their goods. If they don't, export lead industrialization fails. Big imperial nations have options that modern nations don't. Where do these nations export their goods? To the US. Korea had special deals with the US. So did Japan, Taiwan, Hong Kong, Singapore. And even China got special deals (enough to cause Russian complaints). This may be changing, especially for big countries like China with internally developed markets. But this advocacy for ELI should mention the politics of finding places to sell their goods. Otherwise the idea of "protected at home competing abroad" fails.

Singapore, Hong Kong, Taiwan, Korea, Japan all have national IQs >=105

To be sure, this is a highly stylized, pretty speculative theory, which is even harder to prove than Studwell’s. But it kinda-sorta fits the observed pattern in Asia — first Japan and Hong Kong and Singapore grew quickly, then Taiwan and South Korea, then China, now Vietnam and Indonesia. Malaysia and Thailand got a head start on China but then slowed down after the financial crisis of ‘97, while China accelerated — perhaps because China “cut in line” in front of the Southeast Asian tigers. But now, with China slowing down, perhaps Malaysia is back at the front of the line.

Inline links: slowing down

Model City Monday

July 05, 2021 · Original source

The state capacity approach defines the rights and responsibilities of both residents and the government but offers a wider range of flexibility in dealing with unforeseen challenges. The emphasis is not on the state as a contractual service provider, but instead on the state as a positive actor in the development of the city. The Singaporean government, for example, plays an active role in Singapore’s development, building industrial parks, attracting investment, and focusing on the growth of specific industries.

Inline links: active role

I’ve been thinking about this after reading How Asia Works. If Studwell is right, financial hubs are a completely different thing from large-scale development. The great charter city success stories - Dubai, Singapore, Hong Kong - are all stories of cities that became financial hubs. These are great, but you can only have so many financial hubs in a certain region before it gets kind of saturated. If eg Prospera becomes a financial hub for Central America, that’s great and they can be really proud of themselves - but it wouldn’t necessarily be a scaleable plan to lift all of Latin America out of poverty.

Inline links: How Asia Works

Lots of charter cities want to be Lee Kuan Yew’s Singapore. But could a charter city be Park Chung-Hee’s Korea? Sounds like a harder problem, especially since it won’t be immediately profitable (and in fact will be actively less profitable than doing other things in the short-term). Still, it might turn out that that’s what you need if you want to end poverty at scale.

Meetups Everywhere 2021: Times And Places

August 23, 2021 · Original source

SINGAPORE (RSVP) Contact: DG, druidgetafix91[at]gmail[dot]com Time: 5:00 PM, Saturday, September 4 Location: BQ Bar, 39 Boat Quay. Outdoor Seating area, with a ACX Meetup sign. Coordinates: https://w3w.co/units.jelly.chain Notes: Currently in Singapore there is a group size restriction of 5 fully vaccinated (2nd dose +14 days) people. To get into the bar you must show proof of full vaccination, a negative PET result that's valid for the dine-in duration, or proof of recovery from COVID-19.

Inline links: RSVP, https://w3w.co/units.jelly.chain

There's A Time For Everyone

January 12, 2022 · Original source

Our first date, we talked about Singapore’s child tax credits, which gave me advanced notice of where her mind was at. Our second date, we talked about category formation in borderline personality disorder, which later became this post. Our third date, we talked about why Inuit suicide rates were so high, which later became this post.

Inline links: this post, this post

Highlights From The Comments On Health Care Systems

January 27, 2022 · Original source

I've lived in the US, China, Australia, Singapore and Spain. I'm really surprised that the book didn't even consider Spain, which has a pretty cheap system, the world's highest life expectancy at birth and, by far, the best health system of all those I've had a first-hand experience with. No need to tell you much about the US, and Australa's system is, in my limited experience, marginally better. Singapore is hyper-expensive and hyper-effective and anyone who includes China in such a comparison must be doing it for the laughs. Very expensive and second-rate at best in big cities, third-worldist for hundreds of millions in the countryside.

I found out that Singapore has one of the more reasonable healthcare systems out there, with only 4% of GDP spent on world-class service. Basically, it requires the citizens to pay a small part of the healthcare costs out of pocket, and the rest is financed by taxes. There's a lot of interesting intricacies that make it work well, all detailed in this 16-minute video by a good economics youtube channel:

Spring Meetups In Seventy Cities

April 10, 2022 · Original source

SINGAPORE Contact: Paul Pondi (rishifromsg@gmail.com) Date: April 16 Time: 6:30 PM Coordinates: https://plus.codes/6PH57VW2+G3 Location: Tables near the Tea Express, SMU School of Economics, 178903 Notes: After some time, everyone gets up and changes tables to get a chance to talk to more people. Then we all will go for dinner nearby.

Inline links: https://plus.codes/6PH57VW2+G3

Links For April

April 14, 2022 · Original source

32: Adrian D’Souza, on Singapore’s successful anti-child-obesity program. But see the subreddit for some skeptical comments.

Inline links: successful anti-child-obesity program, the subreddit

June 28, 2022 · Original source

Celebration, Florida. But earlier this year, Florida passed a law banning schools from teaching LGBT topics to young children, which the media dubbed “the Don’t Say Gay Law”. Disney did some corporate activism against the law, the Florida government got mad and brainstormed ways to punish Disney, and the best they could come up with was to re-establish state control of Reedy Creek, which DeSantis officially did last month. Disney has sued the state, but it looks like it’s just over some debts and the lawsuit is unlikely to prevent the dissolution. You get socialists in power, they dissolve charter cities. You get conservatives in power, they also dissolve charter cities. All I want is one government that doesn’t dissolve charter cities! Is that too much to ask? Hello, Afropolitan Last year venture capitalist and thought leader Balaji Srinivasan introduced the idea of a “network state”. With the advent of social networks and cryptocurrency, as well as increasing polarization leading people to group themselves more by ideological cohesion than geographic proximity, maybe people could group themselves into nonterritorial state-like communities. And although these would seem pretty thin compared to real states that have monopolies over use of force in real geographic areas, maybe some of them could use charter-city like systems to eventually buy land and graduate into full statehood. (is this just the Hive System from Terra Ignota? I think so, but probably with fewer major governments being controlled by weird brothels.) Anyway, Afropolitan has taken him up on this. They share a name with a landmark essay by Achille Mbembe (founding a country based on an especially good essay also sounds like something that would happen in Terra Ignota, as does history being changed by people named things like “Achille Mbembe”), arguing that Africa needs to re-invent or re-define itself or something. The founders of Afropolitan-the-company have taken this idea of a trans-national African diaspora and turned it into an "African DAO [and] digital nation...building a network state to unleash the maximum potential of Africans around the world". They write: The nation-state experiment has failed for Black people worldwide. It has yielded nothing but poverty, genocide, police brutality, ethnic strife, inflation, weak government, and the failure of our ecosystems. All people who call themselves free have a fundamental right to create the society they want by choice collectively. As the internet enables us to shrink space and form bonds across the planet, no person should live in a society by accident or force. …and go on to list a four-step plan to create the society of the future. Step One is to sell NFTs “representing the mythology of our new nation” . Step Four is “a[n] extensive system of charter cities akin to Singapore or Hong Kong”. In the unlikely chance that you care what Steps Two and Three are, you can find them here. Why should you take them seriously? I am not at all claiming that you should. I am only claiming that “sell digital tokens representing mythology, but eventually this turns into a country” is the most Terra Ignota thing ever. Also, at least the founders have good aesthetics: But also, some people are taking them seriously. VCs including Balaji Srinivasan has invested $2 million. The group claims to have 50,000 followers on Clubhouse. They’ve been featured on TechCrunch and (very briefly) Marginal Revolution. I would, however, briefly challenge their claim to be “the first ever Internet country”. People have been building Internet countries as long as there has been an Internet. I’m not sure which was actually first, but I know the Kingdom of Talossa has been online since 1995. A 2000 New York Times article on the Internet country phenomenon profiled Talossa, but was already able to give six other examples. And although these were perhaps easy to miss, Danny Wallace started the Kingdom of Lovely, a “partly Internet-based project that claims a small amount of territory”, on a widely-viewed BBC documentary in 2007. I myself got involved in an online country project back when I was a teenager in the early 2000s. Although no venture capitalists appeared to give me giant bags of money, it got a few dozen “citizens” and some fun government institutions before finally petering out around 2015. I guess what I’m saying is - I’m available as an Internet country building consultant with fifteen years experience. And no, I don’t accept payment in NFTs. Oh, You’re Still Here? Meanwhile, in Honduras, it isn’t all legal doom and gloom. Prospera has also been making real progress, as measured in pretty photos. Two Roatan resorts, Las Verandas and Pristine Bay, have joined Prospera. The ZEDE law saying that landowners can voluntarily annex their land into a willing ZEDE: Las Verandas Pristine Bay Prospera is also building a high-tech wood processing factory that will eventually produce parts for its other construction efforts: Current construction progress Planned final appearance And its first multi-story apartment buildings: Current construction progress Planned final appearance It will also be hosting gene therapy company Mini Circle, which runs clinical trials for innovative medical procedures. Granting that many of its studies (treatments for HIV, muscular dystrophy, obesity, etc) seem great and important, it perhaps seems suspicious that they would want to do this in a charter city? The company writes that “the cost of running a trial in Prospera is less than 1/1000th the cost of the United States”, which seems good in ways but does not entirely allay my concern. I was originally worried that they would be experimenting on Hondurans or something, but looking at the site it looks like they’re recruiting worldwide and would probably fly Americans (or whoever else) to Honduras for the therapy. Their site features a quote from friend-of-the-blog Alex K Chen, who says: Minicircle's bioscientists have one of the most enlightened risk taking calculi I have observed anywhere. In an environment where extreme hesitance to take any risk holds back scientific progress, they have the openness to imagine, try and measure just about any legal intervention putting them in a very strong position to both produce a significant measurable decrease in the human rate of aging, and to inspire more people to do what they never thought was possible. I think the only way this could get more mad science points is if it used the phrase “small-minded fools”. Mind you, I think mad science points are good, I just hope everyone else sees it that way and my optimism turns out justified. Also, apparently the clinical trials have NFTs, because of course they do. At least they’re not commemorative NFTs - they seem to play a load-bearing role where they help participants be incentivized to complete all the necessary tests. Also, low-cost eco-residences! Shorts 1: I previously mentioned the scam/fiasco/insane-idea of Hammer City, a planned black nationalist city in the Rocky Mountains. I knew it had failed, but I didn’t know exactly how. Now Colorado Sun has investigated. The proximal reason it failed was because the black nationalists started moving their paramilitary onto the land before they had officially bought it, the owner called the cops, and the cops removed them. The Hammer City team has not given back any of the $112,000 which they raised from extremely credulous donors (without using NFTs, even!) 2: The Charter Cities Institute continues doing the long-term ground-level work necessary to create long-term well-grounded charter cities which will be much too boring and responsible for me to write silly profiles of. Some of their most recent work has been with the Africa Next 50 Cities Coalition, which “convenes and mobilizes key stakeholders who are dedicated to harnessing Africa’s rapid urbanization for human prosperity”. 3: Also, CCI founder Mark Lutter has left the organization to start a charter city of his own, no public details yet. CCI will be looking for a new executive director. 4: Speaking of Disney, they’ve been building on their model city expertise and magical storybook branding by creating planned communities around the US - Story Living By Disney, starting with Rancho Mirage California. Realistically it just looks like a very nice planned community, but this planned community comes with the option to have people make fun of you forever for living in a Disney community as an adult. Predictions for this month: Prospera is still substantially a functioning ZEDE in 2025: 70%

Your Book Review: The Internationalists

July 01, 2022 · Original source

The Axis powers stood for the Old World Order. Germany, Japan, and Italy had each rejected the principles of the Peace Pact—Japan by invading Manchuria and continuing into China, French Indochina, British Malaya, Indonesia, and Singapore; Italy by invading Ethiopia, Greece, Yugoslavia, and North Africa; and Germany by seeking to gain control of nearly all of Europe. Each had a reason to resent the Allies and their efforts to outlaw war. The Axis powers had largely missed out on the colonial land grab. Japan only began to participate in international affairs in the 1860s, and it was more than a generation before it was prepared to project military force outside its own borders, too late to successfully participate in the empire-building scramble. Both Germany and Italy finally achieved unification in the same year—1871. They joined the land grab soon after, but were never as successful as France, Spain, Portugal, Britain, and the Netherlands, which built extensive empires. Without the authority to wage war and conquer new territory, the Axis powers saw little possibility of ever achieving equality. (Chapter 8)

An account by a member of the British 23rd Indian Division—known as “The Fighting Cock” for the insignia on the uniforms of the men within it—shows how the colonized turned the colonizers’ ideals against them. During the war, the Japanese had seized control of Indonesia from the Dutch. When the Japanese surrendered in early September 1945, the Fighting Cock went to Java to accept a transfer of authority to Allied forces. In Singapore, en route to Java, an advance party met a “cheerful Dutchman who assumed that he and his countrymen were coming back to the peaceful reoccupation of their Empire.” But the Indonesians had a different idea. To greet the returning imperialists, they covered carriages and vehicles with graffiti declaring: “Atlantic Charter means freedom from Dutch Imperialism.” “Indonesia for Indonesians.” And, simply, “Merdeka”—Freedom. The armed resistance did not abate until the United Nations recognized the country’s independence in 1949.

Your Book Review: Viral

July 30, 2022 · Original source

Although the first SARS virus originated in nature, it was studied in labs after the initial epidemic, and escaped several times, infecting people. This occurred in Singapore, Taiwan, and China, from 2003-2004.

Meetups Everywhere 2022: Times & Places

August 26, 2022 · Original source

BRISBANE, AUSTRALIA Contact: Jarred Filmer, jarred[dot]filmer[at]gmail[dot]com Time: Saturday, September 10, 7:00 PM Location: 52 McCaul Street Taringa (house) Coordinates: 5R4JFXXQ+P8 Event link(s): LessWrong, Facebook event Group info: We used to meet once a month years ago, but now just meet whenever there's a Meetups Everywhere :) Notes: Snacks will be provided but dinner will not be, would recommend eating before you come CANBERRA, AUSTRALIA Contact: Andy Bachler, Andy[dot]Bachler[at]gmail[dot]com Time: Wednesday, August 31, 5:30 PM Location: Badger & Co pub at ANU. Central location, parking free after 5pm, might be loud, sorry! Coordinates: 4RPFP4FC+34 Event link(s): LessWrong, Eventbrite Notes: Parking area just to the north of the pub, over the river, is free after 5pm! GOLD COAST (SOUTH), AUSTRALIA Contact: Lerancan, lerancan[at]gmail[dot]com Time: Sunday, September 11, 2:00 PM Location: A picnic table, Wyberba Street Reserve, Tugun Coordinates: 5R3MVF5W+555 Event link(s): LessWrong Notes: Email me in case of bad weather/you can't find me/you can't make that time etc. MELBOURNE, AUSTRALIA Contact: Ryan, xgravityx[at]hotmail[dot]com Time: Friday, September 2, 6:00 PM Location: Beer Deluxe Federation Square Coordinates: 4RJ65XM9+3Q Event link(s): LessWrong, Facebook event Group info: We're officially the Less Wrong Melbourne social meetup group, though our members include the broader rationalist community. We meet once a month for casual discussion (and beers for those so inclined). Please join our Facebook group to see the meeting invite; there you will see a WhatsApp group link - please join that group too to ensure timely updates in case of changes (Facebook notifications don't work reliably for this). Notes: Please RSVP to the meeting invite on the Facebook group so that I can make an appropriate booking. PERTH, AUSTRALIA Contact: Madge, madgech[at]gmail[dot]com Time: Sunday, September 25, 2:00 PM Location: Russell Square, Northbridge, corner of Shenton and Aberdeen St. There will be some sort of ACX meetup sign. Coordinates: 4PWQ3V34+W6 Event link(s): LessWrong, Facebook event Group info: I run one meetup per year, if someone else wants to take over please do Notes: Please RSVP on LessWrong or Facebook SYDNEY, AUSTRALIA Contact: Eliot, Redeliot[at]gmail[dot]com Time: Thursday, September 15, 6:00 PM Location: City of Sydney rsl, lvl 2 in the fishbowl Coordinates: 4RRH46F4+983 Event link(s): LessWrong, Meetup.com Group info: We meet monthly WOLLONGONG, AUSTRALIA Contact: Jason, jason[dot]bowkettblogs[at]gmail[dot]com Time: Saturday, September 3, 12:00 PM Location: UOW Library Coordinates: 4RQGHVVH+69 Event link(s): LessWrong CHENGDU, CHINA Contact: Alex, acx[dot]chengdu[at]gmail[dot]com Time: Thursday, September 15, 7:00 PM Location: Chef Wenwu Hot & Spicy Jianghu Food (Yulin store)/文武大厨·热辣江湖菜(玉林店). I (a foreigner) will be wearing a green shirt. Coordinates: 8P26J3C5+462 Event link(s): LessWrong Notes: Please RSVP at the above email address, I will give you my Wechat contact if you're interested in attending. Open to time/date/location changes, so let me know if the proposed event doesn't work for you! Can be a bilingual event; all welcome. 有双语交流的可能性。如果想来的话，请提前发给我个电子邮件。 HONG KONG Contact: Nathan, nathan[at]xevarion[dot]org Time: Saturday, September 10, 1:00 PM Location: The Catalyst, 2 Po Yan Street, Sheung Wan. Big wooden door. Coordinates: 862M74PW+6XP Event link(s): LessWrong BANGALORE, INDIA Contact: Nihal, propwash[at]duck[dot]com, Discord: propwash#4648 Time: Sunday, September 18, 4:00 PM Location: Matteo Coffea, Church Street Coordinates: 7J4VXJF4+PR Event link(s): LessWrong Group info: We're the longest active group in Asia — we've been meeting monthly for the last 4 years, discussing ACX posts, LW content with a diverse and friendly group of people. Check our website for more info. Notes: Please RSVP on LessWrong to help me be better prepared. HYDERABAD, INDIA Contact: Vatsal, vmehra[at]pm[dot]me, Whatsapp: +919944430856 (username: Vim) Time: Sunday, September 11, 5:00 PM Location: The Weekend Cafe, Plot No D, 3, Vikrampuri Colony, beside vac's bakery, Vikrampuri Colony, Lane, Secunderabad, Telangana, 500015, India Coordinates: 7J9WFF4X+5P Event link(s): LessWrong Group info: Our rationality meetup group has been around for about 3 months and we discuss articles and exercises (eg. CFAR handbook) that can help us improve epistemic and instrumental rationality. MUMBAI, INDIA Contact: PB, e2y94n1nv[at]relay[dot]firefox[dot]com Time: Sunday, October 9, 4:00 PM Location: Jamjar Diner, Versova Coordinates: 7JFJ4RM6+5W Event link(s): LessWrong Notes: Please RSVP on LessWrong or via email so I can plan activities accordingly. NEW DELHI, INDIA Contact: Suryansh Tyagi, suryanshtyagiphone[at]gmail[dot]com, WhatsApp/phone +919997299972 Time: Sunday, September 11, 5:00 PM Location: Select CityWalk Mall, Saket. Where inside the mall depends on the number of people interested. Coordinates: 7JWVG6H9+8H Event link(s): LessWrong Notes: Please either send me an email or message me on WhatsApp if you want to attend. Any suggestions/changes are welcome. UDAIPUR, RAJASTHAN, INDIA Contact: Shailendra Paliwal, acx-meetup-2022[at]shailendra[dot]me Time: Saturday, September 10, 7:00 PM Location: We'll be at Doodh Talai near Pichola Lake and I'll be wearing a gray t-shirt carrying a sign ACX Meetup Coordinates: 7JPMHM9M+HG Event link(s): LessWrong Notes: Please RSVP on LessWrong so that I can plan ahead UBUD, BALI, INDONESIA Contact: William Ubud, Napaproject[at]gmail[dot]com Time: Tuesday, August 30, 6:00 PM Location: PARQ Ubud Coordinates: 6P3QG789+F7 Event link(s): LessWrong TOKYO, JAPAN Contact: Harold Godsoe, hgodsoe[at]gmail[dot]com Time: Saturday, October 8, 10:00 AM Location: Near Nakameguro station - RSVP for details Coordinates: 8Q7XJPV2+QFP Event link(s): LessWrong, Meetup.com Notes: ACX Tokyo meets monthly since Sept 2021. Our meetups are in English, so far. To join in, feel free to get in touch in any of the many ways to do so (email, Meetup.com). It's useful to be in contact before coming to an event, to help with that first leap of faith. KUALA LUMPUR, MALAYSIA Contact: Yi-Yang, yi[dot]yang[dot]chua[at]gmail[dot]com, LessWrong profile Time: Saturday, September 17, 2:00 PM Location: I'll be in Lisette's Bangsar, which is a 5-minute walk from Bangsar LRT. I'll be wearing a pale green t-shirt and carrying an ACX sign. Coordinates: 6PM34MHH+VW Event link(s): LessWrong AUCKLAND, NEW ZEALAND Contact: Jonathan De Wet, jonpdw[at]gmail[dot]com Time: Saturday, September 3, 6:30 PM Location: 32 Stanley Ave Milford, Auckland Coordinates: 4VMP6QH4+86 Event link(s): LessWrong, Facebook event Notes: It’s a dinner party! Please RSVP on FB so I know how much food to make DUNEDIN, NEW ZEALAND Contact: Gavin, bisga673[at]student[dot]otago[dot]ac[dot]nz Time: Saturday, September 3, 3:00 PM Location: Picnic tables outside of St. David's lecture theatre on Otago University campus. I'll make a sign with ACX meetup. Coordinates: 4V6G4GP7+GM5 Event link(s): LessWrong Notes: There is no Dunedin group as far as I'm aware of, but I'd be keen to meet other likeminded people and organise group hangouts occasionally. WELLINGTON, NEW ZEALAND Contact: Ben W, benwve[at]gmail[dot]com Time: Tuesday, September 27, 5:30 PM Location: Rutherford House, Bunny Street, Wellington. Room MZ05, which is on the mezzanine floor Coordinates: 4VCPPQCH+FGC Event link(s): LessWrong Notes: We're running the event this time in partnership with Effective Altruism Wellington LAPU LAPU, CEBU, PHILIPPINES Contact: Dave, tokkolizard[at]tutanota[dot]com Time: Sunday, September 4, 2:00 PM Location: Starbucks in Mactan Newtown, there will be a sign with ACX MEETUP on it. Coordinates: 7Q268257+4F Event link(s): LessWrong Notes: Please RSVP by mail so I know if I need to set up a bigger meeting place SINGAPORE Contact: Jonathan Ng, jonathan[dot]ng1[at]gmail[dot]com, Telegram @derpy Time: Tuesday, September 6, 6:30 PM Location: Tanjong Pagar MRT gantry, I'll be wearing the dark blue EA Global 2022 jumper Coordinates: 6PH57RGW+J8 Event link(s): LessWrong

Open Thread 240

September 05, 2022 · Original source

2: Worldwide ACX meetup season continues. This week there will be meetups in Singapore on Tuesday, Portland on Friday, Boston and Vienna on Saturday, NYC and Baltimore and Miami on Sunday - plus many more. See the meetups list for details.

Inline links: the meetups list

Book Review: The Geography Of Madness

February 22, 2023 · Original source

This image (source) of a witch stealing a man’s penis, with a box of previously-stolen penises to her right accompanies the 1411 poem “Flowers Of Virtue” in its 1486 edition. Malleus Maleficarum was published in 1486, so if the original text of Flowers Of Virtue contained the incident this picture refers to, it would predate Malleus. But the original text is written in poetic medieval German and I can’t find a good translation. When I wrote my review of the Malleus, people were surprised at the penis-stealing witch chapters. Yet nothing could possibly be less surprising; the penis-stealing witches are timeless and omnipresent. When commenters continued to doubt, I promised them this review of Frank Bures’ Geography Of Madness. II. Frank Bures is a journalist. In 2001, he came across an unusual BBC article: a mob had killed twelve people in Nigeria, believing them to be penis-stealing witches. A few months later, a similar article: five people, Benin. He tried to pitch a story about the phenomenon to his editor, who “said he couldn’t pay me to fly to Nigeria and find essentially . . . nothing”. For some reason - and this is the point at which I start to worry about narrator reliability - Bures became obsessed with this. He couldn’t get it out of his mind. He started scraping together money to visit Africa on his own, story be damned: Nigeria gnawed at me. I knew that it was a terrible time to leave. I knew that [my wife] Bridgit, newly pregnant, wouldn’t want me to go. But I also knew that I had to, and that if I didn’t it would be a lifelong regret. . . three months later, I was the lone tourist on a plane full of Nigerians descending to Lagos. Africa is a relative newcomer to penis-stealing witches: The first recorded incident of penis theft in Africa I could find took place in Sudan in the 1960s. But in the mid- to late seventies in Nigeria, there were waves of well-documented cases. One of these happened in the northern city of Kaduna, where a psychiatrist named Dr. Sunday Ilechukwu was working in his office when a policeman arrived, escorting two men. One of them said he needed a medical assessment: He had accused the other of making his penis disappear. As with [a previously discussed incident], this had caused a disturbance in the street. During Ilechukwu’s examination, he later recounted, the victim stared straight ahead while the doctor examined his penis and pronounced him normal. “Exclaiming,” Ilechukwu wrote in the Transcultural Psychiatric Review, “the patient looked down at his groin for the first time, suggesting that the genitals had just reappeared.” According to Ilechukwu, this was part of an epidemic of magical penis theft that swept through Nigeria between 1975 and 1977. “Men could be seen in the streets of Lagos holding on to their genitalia either openly or discreetly with their hand in their pockets,” Ilechukwu wrote. “Women were also seen holding on to their breasts directly or discreetly, by crossing the hands across the chest . . . Vigilance and anticipatory aggression were thought to be good prophylaxes. This led to further breakdown of law and order.” During an incident, the victim would yell: “Thief! My genitals are gone!” Immediately, a culprit would be identified, apprehended by a crowd, and often killed. …but it’s been making up for lost time. Bures was able to find and interview one previous penis theft victim, plus the friend of another. Both described similar stories: someone had bumped up against them under weird circumstances, they immediately noticed their penis was much smaller than usual, they called out the culprit, and - apparently because the witch involved didn’t want to get in trouble - their penis was restored. Whatever weird itch this topic had given Bures, this didn’t satisfy him. He writes, very lucidly, about a desire to get closer to “the story”. He started bumping up against random Nigerians in suspicious ways, hoping one of them would accuse him of stealing their penis. Bures was an obvious foreigner, and a these panics often resulted in the suspected penis-stealer getting lynched, so this was a crazy thing to do. He could easily have died. Instead, everyone politely ignored him, nothing happened, and a slightly-disappointed Bures flew back to his poor family and abandoned his weird obsession. III. …for four years. After that the bug bit him again and he flew to Asia, long a center of penis-stealing witch activity. There are nature documentaries on lions, dolphins, even dinosaurs. They all share a common pattern: you talk about your subject’s habitat, their diet, their behaviors. The Asian half of The Geography Of Madness has the feel of a nature documentary on penis-stealing witches. And the last beat of every nature documentary has to be: this majestic creature, which once roamed from one end of the region to the other, is now endangered, threatened by increasing globalization and industrial activity. This is true for the witches also. Bures’ time in Hong Kong was a bust. There was a penis theft panic there forty years earlier, and he was able to interview some of the doctors who treated it. But they all said that was long ago. Now everybody is Westernized and has Western fears like vaccine injury or structural racism. They get Western mental disorders like depression and anorexia. The idea of witches stealing their penises seems as risible to them as it probably does to you. Singapore was also a bust. Bures had hoped it wouldn’t be, because it’s full of Malaysians, and Malaysia holds a special place in history as the spot where penis-stealing witches first made contact with Western science. The Malaysian word for the condition is koro (it means “head of a turtle”, based on an analogy to the penis retracting into the body the same way a turtle’s head retracts into its shell), and it is by this name that the condition gets listed in the DSM and the rest of the medical literature. Neither I nor Bures was able to find many ethnic Malays worrying about koro; most of the activity seems to be from Malaysian-Chinese. The Chinese definitely worry about it, attributing it to a wide variety of causes including poisoning, yin-yang imbalance, and - yes - witches. But Bures found nothing among any ethnicity. Once again, all the doctors said it used to be common, but disappeared as the city industrialized and adopted Western ways. Guangzhou was also a bust. The doctors said the same thing - in the old days, there would be huge epidemics of koro, social contagions that would impact hundreds of people at once. Now only a few superstitious rural people still believed. One traditional healer said he saw “three or four” cases a year. All the educated people had moved on. I once saw a nature documentary on Tasmanian tigers. Most people believe these have been extinct since 1930. Still, there are occasional unconfirmed sightings, especially in a remote area called Cape York, and every so often some scientists trudge off to Cape York with traps and cameras in the hopes of getting lucky. Bures decides end his own nature documentary with an expedition to the Cape York of the penis-stealing witches. This is a remote island village in China called Lin’gao, where in 1984: . . . rumors spread of a fox ghost - sometimes disguised an old woman roaming the land—collecting penises in covered baskets she carried on a shoulder pole. When two young men approached her and told her to uncover the baskets, they looked inside, saw that the baskets were filled with penises and died instantly of fright. Panic about koro would hit a village and last three to four days. When residents heard about a case in a neighboring village, the panic would subside, since that meant the ghost had moved on. The attacks slowly made their way around the island. The ghost struck at night, when villagers were sleeping. A chill would creep into the room, and suddenly the victim would feel his penis shrinking inward. He would grab it and run outside for help. A twenty-eight-year-old office worker was at home one night when: > “ . . . he heard a gong being beaten and the terrifying noises made by people who were panicking in a nearby neighborhood. He suddenly became anxious and experienced the sensation that his penis was shrinking. He was seized with panic and shouted loudly for help. Several men in the neighborhood rushed in and tried to rescue him by forcefully pulling his penis and making loud sounds to chase away the evil ghost that was thought to be affecting him.” Neighbors and family members were enlisted in rescue operations. Victims were beaten with sandals and slippers while the middle finger of their left had was squeezed, so that the ghost could exit the body there. The epidemic engulfed the island, with the exception of the Li and Miao minorities, who seemed to be immune to such fears. Researchers estimated that between 2,000 and 5,000 people were affected, but that “no one died from genital retraction.” One baby, however, did die when his mother tried to feed him pepper juice, and a girl was beaten to death during a two-hour exorcism. “Numerous men suffered injuries to their penises as a result of ‘rescuing’ actions.” Iron pins were sometimes inserted through the nipples of women to prevent retraction, which caused infections as well. This was, as far as anyone knows, the last great koro epidemic in Asia. Bures had a terrible time getting to Lin’gao. He had equal trouble getting an interpreter; the natives spoke a language called Be, very distantly related to Thai but not at all to regular Chinese. Finally he found someone who was able to contact a local shaman. Like any good doctor, the shaman referred him to a specialist - in this case, the designated anti-ghost shaman, who lived in a different village. He spent most of his time off on various ghost-fighting missions, but eventually Bures and his team were able to track him down. I want you to picture the scene. An American journalist has been traveling the world in search of a dying variety of witchcraft. Now he’s reached the end of the line, the wildest and most primitive region of China. With great difficulty, he has procured an interpreter. Together, they consult a shaman, who sends them on a quest to find a second, wiser shaman who specializes in ghosts. After many trials and tribulations, he reaches the second, wiser, ghost-specialist shaman, who invites him into his home, filled with strange charms and magical images. “Tell me your question,” says the shaman. And Bures asks: “What do you know about penis-stealing witches?” . . . and the shaman answers: “Haha, no one believes in that stuff anymore.” IV. So as a nature documentary, The Geography of Madness is kind of a bust. Still, Bures rescues it with some great analysis of culture-bound mental illness. A culture-bound mental illness is one that only affects people who know about it, and especially people who believe in it. Often it doesn’t make sense from a scientific point of view (there’s no such thing as witches, and the penis can’t retract into the body). It sometimes spreads contagiously: someone gets a first case, the rest of the village panics, and now everyone knows about it / believes in it / is thinking about it, and so many other people get it too. Different cultures have their own set of culture-bound illnesses. Sometimes there are commonalities - many cultures have something something penis something witches - but the details vary, and a victim almost always gets a case that matches the way their own culture understands it. THESE PEOPLE ARE NOT MAKING IT UP. I cannot stress this enough. There are plenty of examples of people driving metal objects through their penis in order to pull it out of their body or prevent the witches from getting it or something like that. There is no amount of commitment to the bit which will make people drive metal objects through their penis. People have died from these conditions - not the illness itself, which is fake, but from wasting away worrying about it, or taking dangerous sham treatments, or getting into fights with people they think caused it. If you think of it as “their unconscious mind must be doing something like making it up, but their conscious mind believes it 100%”, you will be closer to the truth, though there are various reasons I don’t like that framing. In Rajasthan, India, people come to the hospital with gilahari (lizard) syndrome. Patients say a lizard-like mass, sometimes visible as a skin swelling, is crawling around the body. They express terror that it will reach their airway and suffocate them. Japanese people may contract jikoshu-kyofu, a debilitating fear that they have terrible body odor. No amount of reassurances by friends and psychiatrists can convince these people that they smell normal, nor will any number of deodorants or perfumes make them comfortable. The French suffer from bouffée délirante, where a perfectly healthy person suddenly becomes completely psychotic, with well-formed hallucinations and delusions - then recovers just as suddenly, sometimes over hours or days. This is not how psychosis works anywhere except France and a few former French colonies. Traditional Chinese medicine monitors the balance between yin and yang. The male orgasm can deplete yang, and sure enough in China (but nowhere else) some men suffer traditional symptoms of yang depletion after they orgasm. “The symptoms can last weeks to months after a single orgasm, [and include] chills, dizziness, [and] backache”. The phrase “run amok” comes from Malaysia, where it referred to a specific phenomenon: some person who had been unhappy for a long time would suddenly snap, kill a bunch of people, then say they had no memory of doing it. Malaysian culture totally rolls with this and doesn’t hold it against them; the unhappiness is a risk factor for possession by a tiger spirit, which commits the killings. Although Malays have been doing this since at least the 1700s, there are some fascinating parallels with modern US mass shootings that suggest the damn tiger spirits have finally made it to the US common psychological origins. I have seen exactly one demonic possession case in my ten years as a psychiatrist. The man fell to the ground, mouth foaming, chanting strange syllables and the names of Biblical demons. My attending doctor at the time - one of those people who somehow manages to be an expert in everything - was an expert in demonic possession, and told us that he was in no way psychotic, antipsychotics wouldn’t help him (except insofar as they help everyone by decreasing all behaviors), and he needed to “work through his issues”. The patient was uncooperative - he was only visiting MDs because the local bishop wouldn’t call in an exorcist until he got a psych exam - and eventually left against medical advice. After going down the list, Bures asks the correct next question: how do we know whether or not our own mental illnesses are just as culture-bound as the Japanese or Malaysians’? Cultures that believe in witches have witch-related culture-bound illnesses; cultures that believe in demons have demon-related ones. We believe in science, so we should expect sciencey-sounding culture-bound illnesses, and these might be hard to tell apart from other, more physical conditions. So how suspicious should we be, and of what? Certainly we have some culture-bound mental illnesses. Electromagnetic hypersensitivity is a condition where some people supposedly become very sick when exposed to electromagnetic fields (like from cell phones). This sounds very scientific and makes perfect sense according to our culture, but researchers have found that placebo electrical devices make them exactly as sick as real ones, and that devices they don’t know about don’t make them sick at all. These people’s pain is real, and their lives are very difficult (although a few have found refuge in the National Radio Quiet Zone, an area in Virginia where the government enforces a ban on electromagnetic transmissions for secret military reasons). But their condition only afflicts them because they believe in it, much like with koro. Fine, everyone knows that one’s not real. What about DSM-style mental disorders, the stuff everyone’s supposed to believe in? Are those culture-bound? Unfortunately, I think Bures kind of flubs this section. He decides to focus on PMS (premenstrual syndrome), which is officially included in the DSM as PMDD (premenstrual dysphoric disorder). After discussing the history of hysteria, he writes that: Today, hysteria is never diagnosed, except by unwise husbands. In 1931, however, an American gynecologist named Robert Frank revived the idea in a new guise. He published an article titled, “The hormonal causes of premenstrual tension.” Frank described symptoms that occurred in the week before menstruation: irritability, bloating, fatigue, depression, attacks of pain, nervousness, restlessness, and the impulse for “foolish and ill considered actions,” due to ovarian activity. Again, the cause was the uterus. Then in 1953, British physician Katharina Dalton elaborated on this, arguing the condition came from fluctuation of estrogen and progesterone. She called it Premenstrual Syndrome, and soon symptoms grew to include: anxiety, sadness, moodiness, constipation or diarrhea, feeling out of control, insomnia, food cravings, increased sex drive, anger, arguments with family or friends, poor judgment, lack of physical coordination, decreased efficiency, increased personal strength or power, feelings of connection to nature or to other women, seizures, convulsions, asthma attacks, not to mention flare ups in asthma, allergies, sinusitis, anxiety disorders, irritable bowel syndrome, migraines, and multiple sclerosis. If any of these symptoms occurred in the second half of the menstrual cycle, one had PMS. Estimates of the number of women afflicted ranged from 5 percent to 95 percent. In the 1980s, three women in the UK were tried for arson, assault and manslaughter. The three all claimed they had diminished responsibility due to PMS, and got reduced sentences on the condition that they underwent hormone treatment. After that, according to one study, American women flooded doctors with requests for help with their PMS. “Popular groups like PMS Action were founded to promote recognition and treatment of PMS by medical professionals. Private PMS clinics began to appear in the USA, modeled after those in the UK, and progesterone therapy was enthusiastically adopted, much to the chagrin of many gynaecologists who viewed its use as ‘unscientific’ and ‘commercial’, not to mention unlicensed." Based on all this, the 1987 version of the DSM-III included a new category: Late Luteal Phase Disorder (luteal refers to progesterone). It was proposed as a topic for further research, but despite the absence of such research, it was included in the 1994 edition of the DSM-IV under the name Premenstrual Dysmorphic Disorder, or PMDD.96 In 2013, in the DSM-5, it was given its own category as a full-fledged mental illness. Yet neither PMS nor PMDD occur in most cultures. There are no biomarkers to measure them by. No conclusive correlation has ever been found between estrogen or progesterone levels and PMS. As one study noted, “the more time that women of ethnic minorities spend living in the United States, the more likely they are to report PMDD. Thus, if we are to accept PMDD as a reified medical disorder, then we must also accept exposure to U.S. culture as a risk factor for contracting PMDD.” If it is a syndrome at all, it’s a cultural one. I asked my wife what she thought of this, and she told me: The day before her first-ever period, as a teenager, when she had never really thought about PMS, she felt exceptionally weird, emotional, and generally off, to the point where it seemed to demand an explanation. Then she had her first-ever period, and retroactively explains it as PMS.

Inline links: source, my review of the, Geography Of Madness, Be, gilahari (lizard) syndrome, jikoshu-kyofu, bouffée délirante, suffer traditional symptoms of yang depletion, run amok, Electromagnetic hypersensitivity, National Radio Quiet Zone

The Question Of Separatism

May 19, 2023 · Original source

Of course, nations are an economically important concept because of that one property: they are sovereign, and therefore they write laws and implement policies that affect the economy. These policies can be productively compared. But that’s about it — for everything else, nations aren’t the right way to think about wealth. One reason is simply that they’re very different from one another: “it affronts common sense,” Jacobs writes, “to think of units as disparate as, say, Singapore and the United States, or Ecuador and the Soviet Union, or the Netherlands and Canada, as economic common denominators.” I would add that countries are arbitrary and changing: when the Soviet Union was replaced by 15 sovereign countries, the economic reality didn’t suddenly reshape itself to match the new borders. Lastly, nations contain, under the hood, many sub-economies that are also highly different from one another. None of that is secret or forbidden knowledge. Everyone has always been aware that New York City, or Milan, are economically very different from rural Mississippi or Sicily. But I find that it’s far easier to think in terms of “the United States” or “Italy,” especially when you’re not from there. Nations are an abstraction of real-life complexity, and are accordingly very tempting to use. Also, they’re often the entities that collect statistics, which is another difficult-to-resist temptation for anyone who likes quantitative data. Cities as Radiators of Economic Forces If nations aren’t the best unit to analyze the economy, what is? This is a Jane Jacobs book, so the answer is obviously going to be cities. Jacobs doesn’t actually give a clear argument why. Maybe that was in her previous book, The Economy of Cities. So far as I can see, her reasoning is, ironically, a bit tautological: “all developing economic life depends on city economies; it depends on them by definition because, wherever economic life is developing, the very process itself creates cities and has probably always done so.” But so far as I can see, this reasoning is correct. Cities concentrate people, and therefore economic life, and therefore economic power. The driving force for all this is a phenomenon that, from what I gather, was discovered by Jacobs when she wrote The Economy of Cities: import replacement. Consider, say, Boston back when it was a tiny settlement, not yet a city, in colonial times. At first, Boston didn’t produce much, especially not much that would be of interest to its main trading partner, London. It exported some natural resources: timber, fish. Whatever else the Bostonians needed, they needed to import it from other cities, again mostly London. (Remember to think of imports and exports in terms of cities, not nations.) For instance, at first, all metal tools in Boston came from European cities, and were paid for by the revenue from selling the timber and fish. Then, one day, some Bostonians decided to build an ironworks and make metal tools themselves. (Pictured: a reconstruction of the Saugus Iron Works, established 1646.) This wasn’t of any interest to London or other European cities. The Bostonians weren’t nearly as good or efficient at making metal tools as Londonians were. So Boston couldn’t export the metal tools back to Europe — but it could use them internally, and also export them to other American cities that were about as poor as Boston was, or poorer. Internally, this meant the spark of a manufacturing economy in Boston, as easily obtained metal parts made it easier for other Bostonians to replace other imports from European cities, and eventually develop a symbiotic network of industries. It also meant that the revenue from fish and timber could be used to import new things, including new innovations from European cities (which would later become opportunities for more import replacement). And because there were customers for Boston-made metal goods in New York and Philadelphia, and eventually Cincinnati and Chicago and Pittsburgh as these cities came into existence, it meant additional revenue for Boston that it could reinvest into developing its production further. For Jacobs, virtually all city development can be seen through the lens of import replacement (which, to be clear, has approximately nothing to do with policies of import substitution industrialization; import replacement is not a policy, but a naturally arising free market phenomenon). Her book contains many other examples than Boston, such as Venice, which started off in the early Middle Ages as a small town that sold salt to Constantinople, but then diversified its production to become one of the wealthiest cities of its time; or Taipei and Kaohsiung, two cities in Taiwan that kickstarted their development not long before the 1980s, by forcing expropriated landlords to invest into local import-replacing businesses. One is reminded of Scott’s review of How Asia Works. Import replacement, then, is what makes cities economically powerful. And this power is so great that it causes ripples in distant places. In fact it is the main reason that anything happens at all in non-city areas. Jacobs gives the example of Bardou, a small village in southern France. Bardou looks like this: To the extent that Bardou ever had an economic life, that life was almost entirely driven by distant cities. In ancient times, the area was populated because of iron mines nearby. The mines were exploited to serve the needs of people in the distant cities of Lugdunum (Lyon), Nemausus (Nîmes), or even Rome. As Jacobs notes, we could say that the mines served “the Roman Empire,” but that would be another example of using the abstraction of sovereign countries when we should instead be specific. It was Lugdunum, Nemausus and Rome that wanted the iron — not some random rural area of the empire, and certainly not the part of the empire in which Bardou was located. Eventually the mines and the region were abandoned. More than 1,000 years later, peasants moved into the area and built the modern village. For centuries they lived a wretchedly poor life of subsistence farming. No cities exerted any influence on it, and indeed nothing happened. Then, in the 19th century, the people of Bardou learned that they could improve their situation by moving to distant cities such as Paris, and most of them did. Again, the force wasn’t being exerted by “France”; Bardou was already part of France. The force was specifically being exerted by Paris and other cities with jobs for poor peasants. By the 1960s, only one old man was left. That’s when two foreign visitors, a German and an American, happened upon the village, decided to buy most of it, revitalized it, and turned it into a tourist spot (and even, for a brief time, into a set for a movie company). Today Bardou is a popular place for travelers — who are mostly city people, and spend money that was mostly earned in cities. The Bardou story contains examples of several of the forces that import-replacing cities radiate, according to Jacobs. These forces are central to her thinking. There are five of them: Markets. Cities house a lot of people who need a lot of goods and services, and are therefore strong markets to sell goods and services to. This was the force that acted on the Bardou area when it was a Roman mining region, and again today when it functions as a tourist spot for city vacationers.

Inline links: import replacement, https://substackcdn.com/image/fetch/$s_!5j2T!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F7f2675d9-ce56-4ac5-9b78-a16720269dea_1600x1159.png, import substitution industrialization, Scott’s review of, Bardou, https://substackcdn.com/image/fetch/$s_!RfMs!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fc119b085-f7b3-4e09-a586-9f4fc4c2ea21_1200x1600.png

When people argue against separatism, they often tout the benefits of being large. A Canada that would be split in two would mean smaller markets, and a weaker political counterweight to the United States. (Not to be mean to Canadian readers, but this argument seems delusional to me — I don’t think Americans currently see Canada as a political counterweight of any significance.) It would certainly be less prestigious. Large size, Jacobs says, is associated with power, and we admire power. We love slogans like “unity makes strength.” But after the medium-sized country of Sweden-Norway became the two smaller countries of Sweden and Norway, they both did well. Small size is less powerful, but it has its own advantages, such as nimbleness and ability to fail non-catastrophically. Small size also allows more diversity in cultural and economic matters, and here Jacobs waxes philosophical, pointing out that favoring diversity over uniformity is a recent, post-Enlightenment idea that has not yet been fully embraced in politics. We can see analogs everywhere. Europe, split into numerous small countries from the Middle Ages onward, became far more advanced than China, which has been unified more often than not. The city-states of ancient Greece and Renaissance Italy are seen as golden ages of Western civilization, even if they weren’t part of larger political units and therefore constantly went to war with one another. In business, large companies are impressive and powerful, but people always complain that Google or Microsoft have become stagnant and that the best place to work is tiny startups of about 2 cofounders and 4 employees. In biology, humans are more successful than numerous larger animals, and in terms of raw numbers, small animals like rats or insects are the most successful of all. Jacobs’s point isn’t that smaller is always better. Her point is that the converse statement, “bigger is always better,” is false — despite how intuitive it feels for political entities. Just like we don’t view a small nation like Switzerland or Singapore as a failure of unity, we (and in particular, Canadians) shouldn’t see the secession of a place like Quebec, if it’s done peacefully and democratically, as a failure either. Still, some people in online reviews of the book complain that this argument is a bit thin, especially considering that it serves as the foundation for the later chapters (which are more directly about late 1970s Quebec politics). Sure, small is beautiful, but large states are great for stability, peace, markets, whatever. If the potential benefits of small national size are Jacobs’s strongest argument, then we can breathe a sigh of relief and go back to agreeing that separatism is bad. Pointing out the widespread bias in favor of unified political entities does seem valuable to me, but okay, fair enough. Does Jacobs have deeper reasons why separatism might be a good idea in general? Yes, and for this we go back to the second half of Cities and the Wealth of Nations. Why Nations and Empires Fail Our breathing rate is regulated through a feedback mechanism. Too much carbon dioxide in the blood, or too little oxygen, and the brain stem commands the diaphragm to accelerate breathing. Once the levels are back to normal, the brain stem receives this feedback and slows breathing down again. Now, Jacobs asks, imagine an impossible creature: ten people, all doing their own thing, but whose breathing is somehow regulated by a single brain stem. The feedback the brain stem receives is a consolidated average of everyone’s carbon dioxide and oxygen levels, and the breathing rate the stem decides on is applied to all ten people, regardless of whether they’re sleeping or playing tennis. This, to put it mildly, wouldn’t work. This creature is an analogy, representing a nation. The ten people are its individual cities, and the breathing rate is the cities’ economies. If it sounds like a stupid analogy, that’s because it is: “I have had to propose a preposterous situation,” writes Jacobs, “because systems as structurally flawed as this don’t exist in nature; they wouldn’t last.” Nor do they exist in machines we design; they wouldn’t work. But “nations, from this point of view, don’t work either, yet do exist.” The feedback mechanism that fails to work properly in a nation is currency. A currency always fluctuates according to the exports and imports of the area where it circulates. Let me use the Republic of Venice and its ducat as a toy example, because the coins look nice: Whenever Venice produces something (like salt) and sells it abroad, foreigners need ducats to buy the exports, so the demand for ducats increases. When Venice buys something from abroad, it needs to use foreign currencies, so the demand for ducats decreases. Add up everything that Venice exports and imports, and you get either a trade surplus (more exports than imports) or a trade deficit (more imports than exports), which determines the value of the ducat relative to other currencies. In both cases, a negative feedback loop restores balance over time, just like our brain stem does with carbon dioxide levels. A trade surplus, and therefore a strong ducat, means that when foreigners want Venetian salt, it’s expensive. So Venice’s exports decrease, while imports increase, since Venetians can use their valuable ducats to buy stuff cheaply from abroad. Conversely, a trade deficit makes exports a bargain for foreigners and imports expensive for Venetians. This feedback loop is great. It’s exactly what a city needs to trigger the crucial import replacement process. When exports decrease and a trade deficit begins (maybe because Constantinople found a cheaper source of salt somewhere else), the weak ducat means that Venice is less able to afford the resources and manufactured goods it used to import. The people of Venice don’t want to have less of those goods, though, so they figure out ways to produce some themselves — that is, they do import replacement. Later they will be able to export the output of the newly expanding industries too, strengthening the ducat and continuing the cycle. Currencies, Jacobs explains, function as automatic tariffs (to protect local industry from foreign imports) and automatic export subsidies (to encourage local industry to export). They are “automatic” because of the feedback mechanism. Just like an accelerated breathing rate, they take effect exactly when they are needed — and no longer. … Or so they should, except that import replacement, as we discussed, is a city process. Whereas most currencies are national or supranational. National currencies work well for city-states, like the Republic of Venice or today’s Singapore. But in large nations, which, remember, are not the fundamental unit of economic life, they mess everything up. Take a city like Detroit. When Detroit’s exports (primarily cars) decrease, Detroit gets no feedback about this, because its currency is the United States dollar, and the United States dollar’s value depends on much more than Detroit. It depends on other cities whose foreign exports might be increasing at the moment. And on rural regions that are selling resources like oil abroad. Also, trade between Detroit and other cities that use the United States dollar — i.e., American cities — is structurally unable to provide any feedback whatsoever. So Detroit doesn’t get the signal that it should buy less stuff from other cities and replace the missing imports with local production. Instead, it just declines. Jacobs hypothesizes that this issue of national currencies is at the root of every large country’s economic troubles. It is why nations and empires always centralize everything into one large city, whether that’s Paris, London, Tokyo, or Toronto, or ancient Rome: that city, being the largest, is simply the only one for which national-level currency feedback works fine. The rest of the nation or empire, then, declines. But of course, nations and empires don’t accept this. They care about the economic well-being of their peripheral regions, sometimes out of genuine concern for the people there, sometimes out of fear that they rebel or hold independence referendums. So nations and empires will embark on every possible solution to reverse the decline. All of their solutions will look like good ideas at first, and yet fail at helping the peripheral regions. Worse, these solutions will weaken the cities, thereby destroying the only real wealth of the country and bringing untold hardship for everyone. Eventually the nation or empire will disintegrate, as nations and empires always do, and always will. Jacobs calls these false solutions transactions of decline. She identifies three types, and, content warning, you might not like some of them depending on your political sensibilities. Sustained military production is a transaction of decline. Permanent military bases and garrison towns are a special kind of settlement: they import a lot and export nothing. Superficially, producing weapons and supplies for the military seems like a good deal for some cities — Jacobs gives the example of Seattle, which, before Microsoft and Amazon were a thing, depended mostly on making military aircraft. But because nobody in a military base ever tries to replace those weapons and supplies with their own production, the trade is sterile in terms of economic development. In a sense, the wealth is slowly “drained” from cities. Large empires are especially prone to this: eventually all of their wealth is destined to the military just to keep the empire together.

Inline links: https://substackcdn.com/image/fetch/$s_!YeXj!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F6fe681e6-b571-4f4c-aa90-313f77fc1dbb_750x359.png

Whenever Venice produces something (like salt) and sells it abroad, foreigners need ducats to buy the exports, so the demand for ducats increases. When Venice buys something from abroad, it needs to use foreign currencies, so the demand for ducats decreases. Add up everything that Venice exports and imports, and you get either a trade surplus (more exports than imports) or a trade deficit (more imports than exports), which determines the value of the ducat relative to other currencies. In both cases, a negative feedback loop restores balance over time, just like our brain stem does with carbon dioxide levels. A trade surplus, and therefore a strong ducat, means that when foreigners want Venetian salt, it’s expensive. So Venice’s exports decrease, while imports increase, since Venetians can use their valuable ducats to buy stuff cheaply from abroad. Conversely, a trade deficit makes exports a bargain for foreigners and imports expensive for Venetians. This feedback loop is great. It’s exactly what a city needs to trigger the crucial import replacement process. When exports decrease and a trade deficit begins (maybe because Constantinople found a cheaper source of salt somewhere else), the weak ducat means that Venice is less able to afford the resources and manufactured goods it used to import. The people of Venice don’t want to have less of those goods, though, so they figure out ways to produce some themselves — that is, they do import replacement. Later they will be able to export the output of the newly expanding industries too, strengthening the ducat and continuing the cycle. Currencies, Jacobs explains, function as automatic tariffs (to protect local industry from foreign imports) and automatic export subsidies (to encourage local industry to export). They are “automatic” because of the feedback mechanism. Just like an accelerated breathing rate, they take effect exactly when they are needed — and no longer. … Or so they should, except that import replacement, as we discussed, is a city process. Whereas most currencies are national or supranational. National currencies work well for city-states, like the Republic of Venice or today’s Singapore. But in large nations, which, remember, are not the fundamental unit of economic life, they mess everything up. Take a city like Detroit. When Detroit’s exports (primarily cars) decrease, Detroit gets no feedback about this, because its currency is the United States dollar, and the United States dollar’s value depends on much more than Detroit. It depends on other cities whose foreign exports might be increasing at the moment. And on rural regions that are selling resources like oil abroad. Also, trade between Detroit and other cities that use the United States dollar — i.e., American cities — is structurally unable to provide any feedback whatsoever. So Detroit doesn’t get the signal that it should buy less stuff from other cities and replace the missing imports with local production. Instead, it just declines. Jacobs hypothesizes that this issue of national currencies is at the root of every large country’s economic troubles. It is why nations and empires always centralize everything into one large city, whether that’s Paris, London, Tokyo, or Toronto, or ancient Rome: that city, being the largest, is simply the only one for which national-level currency feedback works fine. The rest of the nation or empire, then, declines. But of course, nations and empires don’t accept this. They care about the economic well-being of their peripheral regions, sometimes out of genuine concern for the people there, sometimes out of fear that they rebel or hold independence referendums. So nations and empires will embark on every possible solution to reverse the decline. All of their solutions will look like good ideas at first, and yet fail at helping the peripheral regions. Worse, these solutions will weaken the cities, thereby destroying the only real wealth of the country and bringing untold hardship for everyone. Eventually the nation or empire will disintegrate, as nations and empires always do, and always will. Jacobs calls these false solutions transactions of decline. She identifies three types, and, content warning, you might not like some of them depending on your political sensibilities. Sustained military production is a transaction of decline. Permanent military bases and garrison towns are a special kind of settlement: they import a lot and export nothing. Superficially, producing weapons and supplies for the military seems like a good deal for some cities — Jacobs gives the example of Seattle, which, before Microsoft and Amazon were a thing, depended mostly on making military aircraft. But because nobody in a military base ever tries to replace those weapons and supplies with their own production, the trade is sterile in terms of economic development. In a sense, the wealth is slowly “drained” from cities. Large empires are especially prone to this: eventually all of their wealth is destined to the military just to keep the empire together.

Meetups Everywhere 2023: Times & Places

August 25, 2023 · Original source

WELLINGTON, NEW ZEALAND Contact: Ben W Contact Info: benwve[at]gmail[dot]com Time: Tuesday, October 3rd, 5:30 PM Location: Room MZ02 (on the mezannine floor), Rutherford House, 33 Bunny Street, Wellington 6011 Coordinates: https://plus.codes/4VCPPQCH+CMR Group Link: facebook.com/EffectiveAltruismWellington Notes: This meetup will be run in collaboration with Effective Altruism Wellington. The external door closes at 6pm, but if you call me I can let you in. reach me on 0+2+7+3+4+4+1+0+8+2 Singapore SINGAPORE Contact: Kon Contact Info: konquek[at]gmail[dot]com Time: Sunday, October 8th, 4:00 PM Location: Large Park (https://www.beesknees.sg/bees-knees-petite) Coordinates: https://plus.codes/6PH58R75+MX

Inline links: https://plus.codes/4VCPPQCH+CMR, facebook.com/EffectiveAltruismWellington, https://www.beesknees.sg/bees-knees-petite, https://plus.codes/6PH58R75+MX

SINGAPORE Contact: Kon Contact Info: konquek[at]gmail[dot]com Time: Sunday, October 8th, 4:00 PM Location: Large Park (https://www.beesknees.sg/bees-knees-petite) Coordinates: https://plus.codes/6PH58R75+MX

Inline links: https://www.beesknees.sg/bees-knees-petite, https://plus.codes/6PH58R75+MX

Highlights From The Comments On Kidney Donation

November 07, 2023 · Original source

Although historically some countries have observed impressive increases after introduction of presumed consent, such as Belgium, others have fared badly with either no difference or an actual drop in organ donation rates, including Singapore, Brazil, Chile, Sweden, and more recently Wales.

Practically-A-Book Review: Rootclaim $100,000 Lab Leak Debate

March 28, 2024 · Original source

Lineage A (left) was used by the Minoan Cretans, but has never been deciphered. Lineage B (right) was used by the Mycaeneans for lists of palace goods. This matches Saar’s story above. The lab leaked to somewhere else in Wuhan, not the wet market. The virus spread undetected in the population for a while. During this time, it mutated to Lineage B. Then one of the people with Lineage B went to the wet market and started a superspreader event. The authorities sampled the patients, found Lineage B, then started looking elsewhere. Later they detected some of the earlier Lineage A cases. The market is unlikely to be the origin of the pandemic, because the original Lineage A strain wasn’t found there. Peter: Although Lineage A is evolutionarily older, Lineage B started spreading in humans first. We know this because Lineage B is more common. Throughout the early pandemic, until the D614G variant drove all other strains extinct, a consistent 2/3 of the cases were B, compared to 1/3 A. Both strains spread at the same rate, so the best explanation is that B started earlier than A. Since COVID doubles every 3-4 days, probably Lineage B started 3-4 days earlier than Lineage A, which explains why it’s always been twice as many cases. But also, Lineage B also has more internal genetic diversity than Lineage A. In general, older viruses have more genetic diversity (the “molecular clock”). This is further evidence that B started spreading first. Pekar 2022 and Pipes 2021 do analyses with known parameters for spread rate and diversity, and find 90%+ odds that Lineage B was the first one in humans. Why did the older strain start spreading later? Probably the virus crossed from bats into raccoon-dogs on some raccoon-dog farm out in the country. It spread in the raccoon-dogs for a while, racking up mutations, including the (less mutated) Lineage A strain and the (slightly more mutated) Lineage B strain. Then several raccoon-dogs were taken to Wuhan for sale, including one with Lineage A and another with Lineage B. The one with Lineage B passed its virus to humans earlier. Then 3-4 days later, the Lineage A one passed its virus to humans. Lineage A was first found in a Wuhan neighborhood right next to the wet market (closer to the wet market than 97% of Wuhan’s population). Again, it would be a bizarre coincidence if a lab leak pandemic was first detected at a wet market. But it would be an even more bizarre coincidence if a lab leak pandemic separated into two strains, and both were first detected at a wet market! Although no known wet market cases were Lineage A, a positive Lineage A environmental sample was found at the wet market, and everyone agrees most cases went undetected. So maybe the Lineage B raccoon-dog spread its virus to a vendor, and that sub-strain mostly stayed in the market. But the Lineage A raccoon-dog spread its virus to a customer, who went back to his house nearby, and that strain spread in the neighborhoods next to the market. This is the only story that explains the evolutionary precedence of A, the greater spread and older molecular clock of B, and the fact that both strains were first found very close to the wet market. Yuri/Saar: Lineage B could be more common and diverse because it got the advantage of a super-spreader event in the wet market. There are a few scattered cases of intermediates between A and B, and a few other scattered cases of lineages that seem even more ancestral (ie closer to the bat virus) than either. This doesn’t make sense in a double spillover hypothesis. But it does make sense if the lineages separated in human transmission somewhere between the lab and the first super-spreader event at the wet market. Peter: Again, the wet market wasn’t a super-spreader event. COVID spread in the wet market at exactly its normal spread rate, doubling about once every 3.5 days. Stop calling the wet market a super-spreader event. The scattered cases of “intermediates” are sequencing errors. They were all found by the same computer software, which “autofills” unsequenced bases in a genome to the most plausible guess. Because Lineage B was already in the software, depending on which part of a Lineage A virus you sequenced, you might get one half or the other autofilled as Lineage B, which looked like an “intermediate”. We know this because all the supposed “intermediates” were partial cases sequenced by this particular software. We can confirm this by noting that there are too many intermediates! That is, where Lineage A is (T/C) and Lineage B is (C/T), the software found both (T/T) “intermediates” and (C/C) “intermediates”. But obviously there can only be one real intermediate form, and we have to dismiss one or the other. But in fact we can dismiss both, because they were both caused by the same software bug. The scattered “progenitor” cases - those closer to the ancestral bat virus than either A or B - are reversions, ie cases where a new mutation in the virus happened to hit an already-mutated base and shift it back towards the ancestral virus. We know this because all of these “progenitors” were scattered cases found months after the pandemic started, often in entirely different countries from Wuhan. If these were real progenitor viruses, they would have either fizzled out or exploded into a substantial portion of all cases, not be found one time in one guy in Malaysia. Given the number of mutations the virus developed over the course of the pandemic, it’s inevitable that some of them would be mutations that bring it closer to the original bat virus, and in fact we find the number of “progenitors” found very nicely matches the number of progenitor-appearing viruses we would expect by chance. And in many cases, we know the “progenitors” are newer than the original lineages, because they also have some of the later mutations that Lineage A or B picked up along the way, alongside their apparent ancestral-bat-virus-like mutations. Session 2: Viral Genetics Yuri: Two years before COVID, scientists at the Wuhan Institute of Virology, together with colleagues at the University of North Carolina, sent in a grant proposal for the DEFUSE program. This program, intended to locate and better understand potential future pandemic viruses, involved going into bat caves and collecting new coronaviruses. Once they had them, they would do gain-of-function: specifically, they would add a furin cleavage site to make them more infectious and see what happened. (quick interlude: COVID’s spike protein has two sections: one binds to human cells through the ACE2 receptor, the other helps fuse with the cell after binding. In order to avoid the immune system, it hides both of these into one spike. But when it reaches a cell, it needs to separate them again. It takes advantage of a human respiratory enzyme, furin, to do the separation - this also ensures that it only infects its primary target, human respiratory cells. The part of COVID that lets it get separated by furin is called the “furin cleavage site”. COVID’s bat-virus ancestors were gastrointestinal viruses; the addition of a furin cleavage site was what made them respiratory viruses.) We’ve found two close relatives of COVID: bat viruses called RATG-13 and BANAL-52. In particular, COVID looks more or less like BANAL-52 plus a furin cleavage site. There are 1500 sarbecoviruses, members of the family of viruses that includes SARS and SARS2/COVID. None of them except COVID have furin cleavage sites. BANAL-52, COVID’s closest ancestor, doesn’t even have anything resembling one that could mutate into a functional furin cleavage site like COVID’s. Instead, COVID - which mostly just resembles BANAL-52 with a few scattered single-point mutations - has twelve completely new nucleotides in a row - a fully formed furin cleavage site that came out of nowhere. There is nowhere else in the genome that COVID differs from BANAL-52 in such a profound way. It’s just BANAL-52 plus a little bit of random mutation plus a fully-formed furin cleavage site that came out of nowhere. Further, the furin cleavage site is weird. It uses the protein arginine twice. But instead of the nucleotides coding for arginine in the usual viral way, both times it uses the codons CGG - the way that higher animals code for arginine. This works fine - it’s just not how viruses do it. So the obvious conclusion is that WIV, which said in 2018 that it was going to find viruses and add furin cleavage sites to them, found a close relative of BANAL-52 and added a furin cleavage site. Since they were humans, and most familiar with the human way of encoding arginine, they added it as CGG both times. COVID seemed surprisingly optimized for infecting humans. Of fifty animals it was tested in, including the usual coronavirus intermediate hosts (pangolins, raccoon-dogs, etc), it was best at infecting human cells. Further, a virus that enters a new species will usually show a burst of mutations as it “figures out” the best way to adapt to that species’ unique biology. But COVID has had a pretty constant mutation rate in humans, from the beginning of the pandemic to the end. That suggests it was already adapted to humans. This could be because the lab screened for viruses with existing adaptations, because they passed it through humanized mice in the lab, or because it adapted in the hundreds of undetected cases that happened between the lab and detection in the wet market. Usually, research with potentially dangerous coronaviruses is done in BSL-3 or 4, ie high to very-high security. But WIV was irresponsibly doing it in BSL-2, ie medium security. The researchers weren’t even required to wear masks. In general, about 1/500 labs will leak any given pathogen they’re working on (?!). But because WIV was researching such an infectious virus in such an irresponsible way, the odds of a leak were much higher. The most likely explanation for all these facts is that WIV went ahead and did the gain-of-function research they said they were going to do (the particular DEFUSE grant proposal we know about got rejected, but it proves that Wuhan wanted to do this, and they could easily have gotten funding somewhere else, or done it out of their regular budget). They found a close relative of BANAL-52 and added a furin cleavage site as a simple twelve-nucleotide insertion, using the human method of encoding arginine that their genetic engineers were familiar with. Then it leaked, spread for a while in the general Wuhan population, and eventually made it to the wet market where it got detected. Peter: As mentioned earlier, the DEFUSE grant was rejected. Further, the grant said that the Wuhan Institute of Virology was responsible for finding the viruses, and the University of North Carolina would do all the gain-of-function research. This was a reasonable division of labor, since UNC was actually good at gain-of-function research, and WIV mostly wasn’t. They had done a few very simple gain-of-function projects before, but weren’t really set up for this particular proposal and were happy to leave it for their American colleagues. Even if WIV did try to create COVID, they couldn’t have. As Yuri said, COVID looks like BANAL-52 plus a furin cleavage site. But WIV didn’t have BANAL-52. It wasn’t discovered until after the COVID pandemic started, when scientists scoured the area for potential COVID relatives. WIV had a more distant COVID relative, RATG-13. But you can’t create COVID from RATG-13; they’re too different. You would need BANAL-52, or some as-yet-undiscovered extremely close relative. WIV had neither. Are we sure they had neither? Yes. Remember, WIV’s whole job was looking for new coronaviruses. They published lists of which ones they had found pretty regularly. They published their last list in mid-2019, just a few months before the pandemic. Although lab leak proponents claimed these lists showed weird discrepancies, this was just their inability to keep names consistent, and all the lists showed basically the same viruses (plus a few extra on the later ones, as they kept discovering more). The lists didn’t include BANAL-52 or any other suitable COVID relatives - only RATG-13, which isn’t close enough to work. Could they have been keeping their discovery of BANAL-52 secret? No. Pre-pandemic, there was nothing interesting about it; our understanding of virology wasn’t good enough to point this out as a potential pandemic candidate. WIV did its gain-of-function research openly and proudly (before the pandemic, gain-of-function wasn’t as unpopular as it is now) so it’s not like they wanted to keep it secret because they might gain-of-function it later. Their lists very clearly showed they had no virus they could create COVID from, and they had no reason to hide it if they did. COVID’s furin cleavage site is admittedly unusual. But it’s unusual in a way that looks natural rather than man-made. Labs don’t usually add furin cleavage sites through nucleotide insertions (they usually mutate what’s already there). On the other hand, viruses get weird insertions of 12+ nucleotides in nature. For example, HKU1 is another emergent Chinese coronavirus that caused a small outbreak of pneumonia in 2004. It had a 15 nucleotide insertion right next to its furin cleavage site. Later strains of COVID got further 12 - 15 nucleotide insertions. Plenty of flus have 12 to 15 nucleotide insertions compared to other earlier flu strains. Sometimes insertions happen because of a mistake in viral replication. Other times the virus gets confused between its own RNA and its host’s, and splices a bit of the host RNA into the virus. This would neatly explain why the insertion used the unusual coding CGG for arginine, which is common in animals but rare in viruses. On the other hand, it’s not that rare in viruses - COVID uses CGG for arginine about 3% of the time. And human engineers don’t necessarily use it any more than that - Peter was able to find one example of humans adding arginine to a virus, and 0 out of the 5 arginines added were CGG. COVID’s furin cleavage site is a mess. When humans are inserting furin cleavage sites into viruses for gain-of-function, the standard practice is RRKR, a very nice and simple furin cleavage site which works well. COVID uses PRRAR, a bizarre furin cleavage site which no human has ever used before, and which virologists expected to work poorly. They later found that an adjacent part of COVID’s genome twisted the protein in an unusual way that allowed PRRAR to be a viable furin cleavage site, but this discovery took a lot of computer power, and was only made after COVID became important. The Wuhan virologists supposedly doing gain-of-function research on COVID shouldn’t have known this would work. Why didn’t they just use the standard RRKR site, which would have worked better? Everyone thinks it works better! Even the virus eventually decided it worked better - sometime during the course of the pandemic, it mutated away from its weird PRRAR furin cleavage site towards a more normal form. Further, COVID’s furin cleavage site was inserted via what seems to be a frameshift mutation - it wasn’t a clean insertion of the amino acids that formed the site, it was an insertion of a sequence which changed the context of the surrounding nucleotides into the amino acids that formed the site. This is a pointless too-clever-by-half “flourish” that there would be no reason for a human engineer to do. But it’s exactly the kind of weird thing that happens in the random chance of evolution. COVID is hard to culture. If you culture it in most standard media or animals, it will quickly develop characteristic mutations. But the original Wuhan strains didn’t have these mutations. The only ways to culture it without mutations are in human airway cells, or (apparently) in live raccoon-dogs. Getting human airway cells requires a donor (ie someone who donates their body to science), and Wuhan had never done this before (it was one of the technologies only used at the superior North Carolina site). As for raccoon-dogs, it sure does seems suspicious that the virus is already suited to them. The claim that COVID is uniquely adapted to humans is false. The paper that claimed that defined how well COVID was adapted to different animals by those animals’ difference (on the relevant cell receptors) from humans. So in its methodology, humans came out #1 by default. If you don’t do that, COVID is better-adapted to many other animals. It’s not necessarily true that viruses see a burst of mutations when they enter a new host. COVID spread to deer and mink, and in neither case was there a burst of mutations. COVID has a pretty simple job of infecting respiratory cells and is already very good at it, regardless of species. In Yuri’s model, Wuhan Institute of Virology picked up a discarded grant and decided to do the gain-of-function half allotted to a different university, despite their relative inexperience. They skipped over all the SARS-like viruses they were supposed to work on, and all the standard gain-of-function model backbones, in favor of BANAL-52, a virus which would not be discovered for another two years, but which they somehow had samples of, which they had for some reason decided to keep secret despite its total lack of interestingness. Then they would have had to eschew all usual gain-of-function practices in favor of inserting a weird furin cleavage site that shouldn’t have worked according to the theory they had at the time, via a frameshift mutation. Then they would have had to culture it, a technique beyond their limited capabilities. Then it would have had to leak, and magically show up again in front of the raccoon-dog stall at a wet market. Yuri: WIV wouldn’t have needed to keep BANAL-52 “secret” in some kind of sinister way. Plenty of researchers have backlogs of work they haven’t published yet. Probably they a found BANAL relative in one of their normal sampling trips, did some preliminary studies on it, and planned to publish it later once they cleaned up their data. Everyone works like this. The part of DEFUSE saying that they would only work on viruses that were 95% similar to SARS is unclear and might mean something else. It looks more like they say they’ll start with those viruses, but also do some work on novel viruses. BANAL-52 could have been one of the novel viruses. The furin cleavage site is weird, but the researchers might have done that on purpose, to make the virus easier to keep track of, or to test different furin cleavage sites. Depending on the exact BANAL-52 relative they used, it might not even be a frameshift; there’s a particular way to spell serine that would make the insertion more natural. The claims that COVID can’t be cultured in normal media are based on speculative original research by Peter and might not hold up. Peter: WIV did most of its virus-gathering in a trip to a Yunnan cave between 2010 and 2015. All those viruses have long since been processed and added to the database. There’s no sign that they made more trips to Yunnan caves, and no reason for them to keep that secret. So the idea that they might just have some new viruses they didn’t publish doesn’t hold up. But suppose they did make more trips. Given the amount of time between the DEFUSE proposal and COVID, if they kept to their normal virus-collection rate, they would have gotten about thirty new viruses. What’s the chance that one of those was BANAL-52? There are thousands of bat viruses, and BANAL-52 is so rare that it wasn’t found until well after the pandemic started and people were looking for it very hard. So the chance that one of their 30 would be BANAL-52 is low. Also, they said in DEFUSE that they planned to go back to the same Yunnan cave. But BANAL-52 was found far away from that cave, so unless it ranged over a wide area, they probably couldn’t have found it even if they got very lucky. Session 3: Closing Arguments This third debate was supposed to be about “inference”, ie how much Bayesian evidence was provided by each of the facts given so far, and how to fit them into the Rootclaim probabilistic model. I’m going to relegate my summary of the more probabilistic half to the next section of this post, and just include the closing arguments here. Saar: Peter’s case hinges on the idea that it’s very improbable that a lab leak pandemic would first show up at a wet market. But this isn’t necessarily improbable. The Huanan Seafood Market had several factors that made it a likely location for a superspreader event. It was busy, with over 10,000 visitors a day. Many of the people there (eg the 1,000 vendors) came back daily, letting them reinfect each other. It had poor ventilation, especially in the high-positivity area near the raccoon-dog stall. It had cold wet surfaces on which the virus could survive for long periods. It was indoors, which prevented UV light from killing the virus. Given a small amount of sporadic COVID going around Wuhan, it’s not surprising for the first place it started spreading en masse to be a wet market. In fact, we have several examples of this. When China was COVID Zero, there would occasionally be small outbreaks that the authorities would have to contain. Most of these were at wet markets. For example, the big COVID outbreak in Beijing started at Xinfadi Market, their local seafood market. This couldn’t be an animal spillover, because there were no raccoon-dogs or other weird wildlife there. So it must be that wet markets are natural places for superspreader events. There are several other examples, which make up about half of the total outbreaks in Zero COVID era China, plus others in Singapore and Thailand. Since COVID clusters concentrate in wet markets even when there is no animal spillover, we should accept this as a property of the virus, and not attribute any significance to the fact that this happened in Wuhan too. Peter: About 1/10,000 citizens of Wuhan was a wet market vendor. So there’s a 1/10,000 chance that the first known COVID case should be a wet market vendor by chance alone. Weibo lists the most popular places for people to check in to their network on their phones, and the wet market was the 1600th most popular place in Wuhan, meaning that if you weight locations by busy-ness, there’s a less than 1/1600 chance that the first cases would be in the wet market. Yes, the wet market is indoors, has mediocre ventilation, has repeat visitors, etc. So do thousands of other places in Wuhan, like schools, hospitals, workplaces, places of worship. The wet market isn’t special in any way. And again, it wasn’t a superspreader event! COVID spread at the same rate in the wet market as it does everywhere else: doubling once per 3.5 days. It doesn’t matter what kinds of arguments you can come up with for why the wet market should have been the perfect superspreader event location, we can look at it and see that it wasn’t. It’s an environment that spreads COVID at exactly the normal rate. Zero COVID era Chinese outbreaks were concentrated in wet markets because they received infected animal products. We know why there was an outbreak in the Xinfadi Market in Beijing: it was because the seafood stall got frozen fish from some non-Zero-COVID country, the fish had COVID particles on it, and the vendor got infected and spread it to everyone else. Something like this is true for the other Chinese wet market based outbreaks we know about it. So this makes the opposite point you think it does: wet markets start outbreaks because there are infected goods being sold there. Then the virus spreads through the wet market at a completely normal rate. Saar: The Weibo list of 1600 places bigger than the wet market is likely inaccurate, because it's based on check-in data and people don't check in to seafood markets. Most of those 1600 places aren't amenable to superspread. The 70 markets supposedly bigger than Huanan are irrelevant, because they're supermarkets, open air markets, etc. Huanan is the largest seafood market in central China, and a more likely place for the first cluster of cases to be noticed. Markets weren't a common spillover location in SARS1, so the zoonosis hypothesis hasn't "called" this event in a way that should give them a high Bayes factor. And there’s still plenty of evidence for isolated (though not super-spreading) pre-market cases. A British expatriate in Wuhan, Connor Reed, says he got sick in November, three weeks before the first wet market case. Later the hospital tested his samples and said it was COVID. Another paper reports 90 cases before the first wet market one. Peter: Connor Reed was lying. The case wasn’t reported in any peer-reviewed paper. It was reported in the tabloid The Daily Mail, months after it supposedly happened. He also told the Mail that his cat died of coronavirus too, which is rare-to-impossible. Also, to get a positive hospital test, he would have had to go to the hospital, but he was 25 years old and almost no 25-year-olds go to the hospital for coronavirus. His only evidence that it was COVID was that two months later, the hospital supposedly “notified” him that it was. The hospital never informed anyone else of this extremely surprising fact which would be the biggest scientific story of the year if true. So probably he was lying. Incidentally, he died of a drug overdose shortly after giving the Mail that story; while not all drug addicts are liars, given all the other implausibilities in his story, this certainly doesn’t make him seem more credible. And in any case, he claimed he got his case at a market “like in the media” The other 90 cases are also fake. A lab leak guy found a paper that mentioned 90 more cases than other papers, and made up a conspiracy theory where the author was trying to secretly communicate that there had been 90 secret cases before any of the confirmed cases, even though there was nothing about this in the text of the paper. But actually that paper just counted cases differently than other papers, and they were referring to normal cases after the pandemic officially started. Again, I’ll come back to the discussion about inference later, but for now, here’s a table of both sides’ reasoning. This exact presentation comparing both analyses is mine3, but you can see Saar’s version here, and Peter’s starting at 45:33 of this video. Slightly made up; the two sides didn’t express their probabilities in the same way and I had to make editorial decisions to match them. Note that these aren't entirely comparable because Peter is being laxer about out-of-model probability than Saar. Although Saar's final odds here are 533-to-1, this just the central estimate. Rootclaim’s real final probability is 94% lab leak. You can see their analysis here. And The Winner Is . . . … … … … … Peter and the zoonosis hypothesis. This was a decisive victory. There were two judges, who each gave separate verdicts (or were allowed to declare a draw). Both judges decided in favor of Peter. You can see the judges’ own summary of their reasoning here (Will, Eric) Manifold agreed with the judges. There was a prediction market on who would win. It started out 70-30 in favor of lab leak. As the videos came out, zoonosis started doing better and better. I don’t want to take the exact final numbers too seriously, since I think some of the later price increases involved hints from the participants’ behavior. But it’s clear which way viewers thought the wind was blowing4. Around the same time, the Good Judgment Project - Philip Tetlock’s group studying superforecasters - put out a report on the lab leak hypothesis. After studying it in depth, his forecasters ended up 75-25 in favor of zoonosis. The Rootclaim debate was one of ten sources they said they found especially interesting. And also around the same time, and unrelated to any of this, the Global Catastrophic Risks Institute surveyed experts (“168 virologists, infectious disease epidemiologists, and other scientists from 47 countries”) and found the same thing (though see here for some potential problems with the survey): For what it’s worth, I was close to 50-50 before the debate, and now I’m 90-10 in favor of zoonosis. III. The Math And The Aftermath The third debate session was about “inference”, how to put evidence together. I put this part off until after disclosing the winner, because I wanted to talk about some of these issues at more length. The Math: Judges Both judges included a probabilistic analysis in their written decision. Here’s the same table as above, expanded to add the judges: I shoehorned the judges’ factors into the categories I already had; some of them were actually subtly different from Peter’s, Saar’s, and each other’s. The “priors” category is especially a mess here. We’ll go over these later, but I get the impression that they both thought of probabilistic analyses as an afterthought. For example, Judge Eric wrote 30,000 words about which considerations moved him, and only then includes the analysis, saying: I am not convinced that this Bayesian calculation is even an appropriate way to estimate the relative posterior probability of Z and LL; it just seemed fair that after criticizing Rootclaim’s calculations at length I should make an attempt at it myself. Judge Will’s decision ran to 10,000 words. He said he independently tried both reasoning it out intuitively, and running the Bayesian analysis, and was relieved when these two methods returned the same result. He said: I am skeptical that the Bayesian decision making/evaluation methods are any more "objective" than [intuitive reasoning]. I think they maximize legibility, not objectivity, and tend to hide the intuitive/heuristic portion in the data inclusion step and values, where it’s harder to see . . . I am not skilled in the Bayesian method, and I am sure I made significant mistakes. More time and practice would improve and refine my estimates. At the fundamental rules of the universe level, Bayesian analysis must be the best way to evaluate evidence. However, I am unsure that it’s a good strategy for a human given our cognitive limitations, and doubly unsure it’s truly being used (in the dispassionate sense) where the outcome is social desirability/fame/Twitter likes. I’m focusing on this because Saar’s opinion is that the debate went wrong (for his side) because he didn’t realize the judges were going to use Bayesian math, they did the math wrong (because Saar hadn’t done enough work explaining how to do it right), and so they got the wrong answer. I want to discuss the math errors he thinks the judges made, but this discussion would be incomplete without mentioning that the judges themselves say the numbers were only a supplement for their intuitive reasoning. That having been said, let’s look deeper into some of Saar’s concerns. The Math: Extreme Odds Saar complained that Peter’s odds were too extreme. For example, Peter said there was only a 1/10,000 chance that a lab leak pandemic would first show up at a wet market. Peter’s argument went something like: obviously a zoonotic pandemic would start at a site selling weird animals. But a lab leak pandemic - if it didn’t start at the lab - could show up anywhere. 1/10,000 Wuhan citizens work at the wet market. So if a lab leak was going to show up somewhere random, the wet market was a 1/10,000 chance. Saar had specific arguments against this, but he also had a more general argument: you should rarely see odds like 1/10,000 outside of well-understood domains. In his blog post, he gave this example: A prosecutor shows the court a statistical analysis of which DNA markers matched the defendant and their prevalence, arriving at a 1E-9 probability they would all match a random person, implying a Bayes factor near 1E9 for guilty. But if we try to estimate p(DNA|~guilty) by truly assuming innocence, it is immediately evident how ridiculous it is to claim only 1 out of a billion innocent suspects will have a DNA match to the crime scene. There are obviously far better explanations like a lab mistake, framing, an object of the suspect being brought by someone to the scene, etc. So the real p(wet market|lab leak) isn’t the 1/10,000 chance a pandemic arising in a random place hits the wet market, but the (higher?) probability that there’s something wrong with Peter’s argument. Then Saar tried to show specific things that might be wrong with Peter’s argument. I didn’t find his specific examples convincing. But maybe the question shouldn’t be whether I agreed with him. It should be whether I’m so confident he’s wrong that I would give it 10,000-to-1 odds. This makes total sense, it’s absolutely true, and I want to be really, really careful with it. If you take this kind of reasoning too far, you can convince yourself that the sun won’t rise tomorrow morning. All you have to do is propose 100 different reasons the sunrise might not happen. For example: The sun might go nova.

Inline links: Pekar 2022, Pipes 2021, says, 3, here, this video, https://substackcdn.com/image/fetch/$s_!8aU2!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F815fe32d-d7ea-401b-b3a2-d8cd25b52ee8_490x780.png, https://substackcdn.com/image/fetch/$s_!0Tm_!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fd0492f69-7b7e-4611-9d76-64ef8d7f59d5_511x511.png, Will, Eric, agreed, 4, put out a report on the lab leak hypothesis, https://substackcdn.com/image/fetch/$s_!g7k2!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F37f1b493-b556-41ec-925e-03f9d8bc26cb_1456x849.webp, surveyed experts, see here, https://substackcdn.com/image/fetch/$s_!Zejl!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fe9c88e87-b6ca-4c6d-840e-24da726f50b7_975x365.png, https://substackcdn.com/image/fetch/$s_!T5rV!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F4983e2cd-4151-42de-9685-08037ef7a8e8_635x788.png

Spring Meetups Everywhere 2024

March 30, 2024 · Original source

KUALA LUMPUR, MALAYSIA Contact: Yi-Yang Contact Info: yi[dot]yang[dot]chua[at]gmail[dot]com Time: Sunday, April 21st, 2:00 PM Location: We'll be in Kings Hall Cafe @ Sec 13 (https://maps.app.goo.gl/HXKPbcMKhvRsb4ue8). Look for an "ACX meetup" sign. Coordinates: https://plus.codes/6PM34J7R+R4 Singapore SINGAPORE Contact: Andrew Contact Info: mindupgrade[at]protonmail[dot]com Time: Sunday, May 12th, 4:00 PM Location: Maxwell (will send more details in email) Coordinates: https://plus.codes/6PH57RJV+5W Group Link: https://rentry.co/AC6PH57RJV5W Notes: We have at least one ACX Meetup every month. The Jun/Jul/Aug/Sep/Oct dates will be on https://rentry.co/AC6PH57RJV5W (our Group Link). Please send your RSVP email early because it would be immensely helpful. Feel free to send an email about topic sentences that you are interested in or want to have a conversation with others about. Topic sentences will be collated and shared with the other attendees.

Inline links: https://maps.app.goo.gl/HXKPbcMKhvRsb4ue8, https://plus.codes/6PM34J7R+R4, https://plus.codes/6PH57RJV+5W, https://rentry.co/AC6PH57RJV5W

SINGAPORE Contact: Andrew Contact Info: mindupgrade[at]protonmail[dot]com Time: Sunday, May 12th, 4:00 PM Location: Maxwell (will send more details in email) Coordinates: https://plus.codes/6PH57RJV+5W Group Link: https://rentry.co/AC6PH57RJV5W Notes: We have at least one ACX Meetup every month. The Jun/Jul/Aug/Sep/Oct dates will be on https://rentry.co/AC6PH57RJV5W (our Group Link). Please send your RSVP email early because it would be immensely helpful. Feel free to send an email about topic sentences that you are interested in or want to have a conversation with others about. Topic sentences will be collated and shared with the other attendees.

Inline links: https://plus.codes/6PH57RJV+5W, https://rentry.co/AC6PH57RJV5W

Open Thread 324

April 08, 2024 · Original source

2: ACX meetups this coming week in Haifa, St. Petersburg, LA, Toronto, Vancouver, Mexico City, San Jose, Milwaukee, Hong Kong, Tallinn, Cambridge MA, Mumbai, Singapore, and many more. See the Meetups List for details.

Inline links: See the Meetups List for details

Open Thread 328

May 06, 2024 · Original source

1: More meetups this week in Helsinki, Waterloo, Sao Paulo, Raleigh-Durham, Tokyo, Copenhagen, Munich, Oslo, Barcelona, Montreal, Ottawa, Singapore, San Antonio, Denver, Warsaw. See the meetups post for more info. And note addition of Kaduna, Nigeria.

Inline links: the meetups post

Highlights From The Comments On Mentally Ill Homeless People

July 18, 2024 · Original source

See my review of Revolt Of The Public. As I tried to say in the first part of the post, this is reasonable and sympathetic. But if people keep not listening to your demands, then learning more about the specifics might help you understand why. There’s a dynamic in gun control debates, where the anti-gun side says “YOU NEED TO BAN THE BAD ASSAULT GUNS, YOU KNOW, THE ONES THAT COMMIT ALL THE SCHOOL SHOOTINGS”. Then Congress wants to look tough, so they ban some poorly-defined set of guns. Then the Supreme Court strikes it down, which Congress could easily have predicted but they were so fixated on looking tough that they didn’t bother double-checking it was constitutional. Then they pass some much weaker bill, and a hobbyist discovers that if you add such-and-such a 3D printed part to a legal gun, it becomes exactly like whatever category of guns they banned. Then someone commits another school shooting, and the anti-gun people come back with “WHY DIDN’T YOU BAN THE BAD ASSAULT GUNS? I THOUGHT WE TOLD YOU TO BE TOUGH! WHY CAN’T ANYONE EVER BE TOUGH ON GUNS?” I don’t know if the anti-gun people are doing anything wrong here exactly, I just know they’re going to be constantly confused and disappointed, and that anyone else who tries the same strategy will get the same results. Realistically, my excuse for writing the post was that I read this and this article by Freddie deBoer which assume that there is some clearly-defined thing called “involuntary treatment” and that the kindest option for the mentally ill and everyone else is to lift some kind of law preventing us from delivering it. Even if it’s permissible for the average person to just say “less homeless crime, please”, I feel like at the point where you’re a public intellectual leading the public discussion, you have some responsibility to start talking specifics. 2. Specific Comments And Responses Shako (blog) writes: I agree with your point in the post. I’ll add though that a policy that is adjacent to this is be “cruel and draconian” to the subset of homeless who commit anti-social crimes. If we removed the subset of criminals from west coast homelessness the problem would be still visible but far far less concerning to those of us who live among it. This is where I land too, but I think it’s very hard. If a homeless person stabs someone, then I think most places (I don’t know if this includes SF), they get prosecuted under general anti-stabbing laws, which the police mostly have enough resources to investigate. If someone just gets in people’s face a lot and screams and litters, then what? Most of the time, police won’t be around to see this. Most of the time, the victim won’t go through the trouble of pressing charges. If they did, it would be he said, she said. Even if the government puts in the effort to actually try the case, screaming at people and littering is probably a couple-month sentence at most. Eledex tells a related story in Part 3 here. A group of homeless people took up residence in an empty lot next to his house, harassed him, set things on fire, etc. This is much worse than the average homeless person just bothering tourists, but when he called the police, they never followed up. I assume if they had tried, the homeless people’s public defender could have said something like “are you sure these homeless people are the same ones who set fire to your stuff?”, Eledex would have said “they’re the homeless people camping on the lot where it happened, but I don’t, like, recognize them or anything”, the public defender would have said “well how do you know those people didn’t leave and some new homeless people came on to the lot?” and everyone would admit they couldn’t prove that. So the normal criminal system might not be set up to deal with these kinds of issues, which I think is why there’s so much demand for some extreme law that criminalizes the entire concept of being this sort of person. But I do worry that if police don’t have the resources to deal with normal crimes, then whoever is charged with enforcing the new extreme law won’t have enough resources to do it well either - and that any society capable of enforcing the new extreme law would also be capable of solving this through normal policing. Humphrey Appleby writes: Can we look at what other places do? What is eg Salt Lake City’s solution? (Possibly, export the homeless to SF). What about Zurich? Singapore? Edinburgh? The US in general and SF in particular seems to have this problem unusually bad, so one could reasonably look elsewhere for ideas. I talk a little more about this at https://www.astralcodexten.com/p/book-review-san-fransicko, but I think most places' solutions are a combination of: 1. Cheaper housing so that more people can afford homes 2. Cheaper housing so that the government has an easier time giving free homes to people who can't afford their own 3. Homeless shelters 4. Frequent bad weather, forcing the homeless to use the homeless shelters at least sometime, which gets their foot in the door 5. Laws requiring the homeless to use the homeless shelters, which I am much less against when the homeless shelters exist. Doktor Zum writes: At one point, there were something like 600,000 Americans in long-term psychiatric institutions, and that was in a less populous America. Start by locking up 600K and then lock up more. Ah, but where do you put them? The 50 states are dotted with the creepy and picturesque ruins of all the old mental asylums--you can't put them there! It's true that the current government (states, local and federal) are totally incapable of building and running a vast network of psychiatric hospitals, but don't we want government to do things like build nuclear power plants and also lots of housing? If I'm making an argument for cheaper housing and you say "government can't/won't ever allow more building," am I supposed to say that you have won the argument? Unless we want to embrace full anarcho-capitalism, we have to believe that it is possible to have a government that can do things that it did in the 1950s like (a) apprehend and detain the severely mentally ill, (b) back and create lots of nuclear power plants, and (c) build abundant housing and infrastructure. People say “we had giant institutions once, so we can do it again”. This is basically true, but with some missed subtlety. The 600,000 people in the old institutions included: Demented old people (eg Alzheimers)

Inline links: my review of Revolt Of The Public, this, this, blog, here, https://www.astralcodexten.com/p/book-review-san-fransicko

Meetups Everywhere 2024: Times & Places

August 29, 2024 · Original source

Contact: Mark Contact Info: markgilmour[at]gmail[dot]com Time: Saturday, September 21st, 10:00 AM Location: Cornwall Park Band Rotunda Coordinates: https://plus.codes/4VMP4Q3Q+RR Notes: Bring kids if relevant, feel free to bring some nibbles. Singapore SINGAPORE, SINGAPORE Contact: Andrew Contact Info: mindupgrade[at]protonmail[dot]com Time: Sunday, September 29th, 04:30 PM Location: Maxwell (will send more details in email) Coordinates: https://plus.codes/6PH57RJV+5W Group Link: https://rentry.co/AC6PH57RJV5W. Please send your RSVP email as early as you can because it would be immensely helpful. Notes: Feel free to send an email about topic sentences that you are interested in or want to have a conversation with others about. Topic sentences will be collated and privately shared with the other attendees. We have at least one ACX Meetup every month. The Aug/Sep/Oct/Nov/Dec dates will be on https://rentry.co/AC6PH57RJV5W.

Inline links: https://plus.codes/4VMP4Q3Q+RR, https://plus.codes/6PH57RJV+5W, https://rentry.co/AC6PH57RJV5W, https://rentry.co/AC6PH57RJV5W.

How To Stop Worrying And Learn To Love Lynn's National IQ Estimates

January 15, 2025 · Original source

Richard Lynn was a scientist who infamously tried to estimate the average IQ of every country. Typical of his results is this paper, which ranged from 60 (Malawi) to 108 (Singapore).

Inline links: this paper

Meetups Everywhere Spring 2025: Times & Places

March 25, 2025 · Original source

Contact: Mark Contact Info: markgilmour[a t]gmail[period]com Time: Sunday, April 6th, 3:00 PM Location: Cakes & Ladders, 173 Symonds St, Auckland. I'll have a small sign. Coordinates: https://plus.codes/4VMP4QP6+WC Group Link: Email me for an invite to the WhatsApp group Notes: We have a small existing meetup group, if you are reading this then you should absolutely come along and check it out. You should RSVP so you feel obligated to follow through :p Singapore SINGAPORE Contact: Ewan Contact Info: ewantsun0[a t]gmail[period]com Time: Saturday, April 5th, 2:30 PM Location: Address: 8 Marina View, #02-08/10 Asia Square Tower 1, Singapore 018960 (Asia Square Food Garden) I'll be at the centre of the Food Garden, wearing a green shirt. (There won't be any 'ACX Meetup' sign, but there shouldn't be anyone else at the venue so there's little risk of getting confused with another group.) Coordinates: https://plus.codes/6PH57VH2+CJ Group Link: https://t.me/+I3z [remove this part] ep9OOJU83NjFl. A LessWrong group is here: https://t.me/Less [remove this part] Wrong_Singapore Andrew, a different organizer, has monthly meetups here: https://rentry.co/AC6PH57RJV5W Notes: Vis-a-vis navigation: (1) Asia Square is just a short walk from Shenton Way MRT Station. (2) Please go to the right tower (Tower 1)! Also note that the Food Garden will be closed, but I'll be bringing some (vegan-friendly) food and drinks.

Inline links: https://plus.codes/4VMP4QP6+WC, https://plus.codes/6PH57VH2+CJ, https://rentry.co/AC6PH57RJV5W

Contact: Ewan Contact Info: ewantsun0[a t]gmail[period]com Time: Saturday, April 5th, 2:30 PM Location: Address: 8 Marina View, #02-08/10 Asia Square Tower 1, Singapore 018960 (Asia Square Food Garden) I'll be at the centre of the Food Garden, wearing a green shirt. (There won't be any 'ACX Meetup' sign, but there shouldn't be anyone else at the venue so there's little risk of getting confused with another group.) Coordinates: https://plus.codes/6PH57VH2+CJ Group Link: https://t.me/+I3z [remove this part] ep9OOJU83NjFl. A LessWrong group is here: https://t.me/Less [remove this part] Wrong_Singapore Andrew, a different organizer, has monthly meetups here: https://rentry.co/AC6PH57RJV5W Notes: Vis-a-vis navigation: (1) Asia Square is just a short walk from Shenton Way MRT Station. (2) Please go to the right tower (Tower 1)! Also note that the Food Garden will be closed, but I'll be bringing some (vegan-friendly) food and drinks.

Inline links: https://plus.codes/6PH57VH2+CJ, https://rentry.co/AC6PH57RJV5W

Open Thread 375

March 31, 2025 · Original source

1: Meetups this week include SF, San Jose, Melbourne, Bonn, Singapore, and Florence. And some late additions to the schedule, including Hanover, Bonn, and Ahmedabad. See here for details.

Inline links: here

Meetups Everywhere 2025: Times and Places

August 29, 2025 · Original source

Contact: Benji Cresswell Contact Info: notevil101[a t]gmail[period]com Time: Saturday, September 27th, 3:00 PM Location: 29 Brandon St, Wellington Central, Wellington 6011, New Zealand. In the Tūī room Coordinates: https://plus.codes/4VCPPQ8G+GF Notes: Please RSVP on Lesswrong, as the meeting room is quite small. Singapore SINGAPORE Contact: Jonathan Ng Contact Info: jonathan[period]ng1[a t]gmail[period]com Time: Saturday, September 13th, 7:00 PM Location: Coordinates: https://plus.codes/6PH58W8W+HJ Group Link: https://t.me/LessWrong_ [remove this bit] Singapore, https://rentry.co/AC6PH57RJV5W, https://t.me/+I3z [remove this part] ep9OOJU83NjFl Notes: partiful.com/e/6ghe2pwx2e2j4q9y2nyj

Inline links: https://plus.codes/4VCPPQ8G+GF, https://plus.codes/6PH58W8W+HJ

Contact: Jonathan Ng Contact Info: jonathan[period]ng1[a t]gmail[period]com Time: Saturday, September 13th, 7:00 PM Location: Coordinates: https://plus.codes/6PH58W8W+HJ Group Link: https://t.me/LessWrong_ [remove this bit] Singapore, https://rentry.co/AC6PH57RJV5W, https://t.me/+I3z [remove this part] ep9OOJU83NjFl Notes: partiful.com/e/6ghe2pwx2e2j4q9y2nyj

Inline links: https://plus.codes/6PH58W8W+HJ

Open Thread 398

September 08, 2025 · Original source

1: Meetups this week include Abuja, Dublin, Ho Chi Minh City, London, Manchester, Montevideo, Montreal, Moscow, Munich, Nairobi, Ottawa, Rio, Santiago, Singapore, Stockholm, Tokyo, Baltimore, Berkeley, Madison, Phoenix, Pittsburgh, Seattle, and many others. And late additions to the meetup list include Vilnius, Haifa, Vegas, and Durham. See the list for more.

Inline links: Berkeley, the list

Your Review: Project Xanadu - The Internet That Might Have Been

September 19, 2025 · Original source

Eric Hill, a 15-year-old hacker and indicted felon, who “had been dismissed by the judge with admiration.” In Swarthmore, Nelson hoped his decades-old dream of Xanadu would finally materialize. 5. Developing Xanadu Ted Nelson had built Project Xanadu into, for lack of better terminology, a cult.8 He writes: We all were deeply concerned about the Bad Guys, who we saw as a combination of IBM and the government. (The others were all Libertarians, I still called myself a Cynical Socialist.) The Bad Guys would spy on people, withhold and block information, and give us inferior hypertext. We had to Do It Right, to help prevent this. This meant using the standard business defenses—especially non-disclosure agreements (I made all of them sign) and secret proprietary algorithms. The Xanadians had a messiah—Ted Nelson—a gospel—Computer Lib—a persecution complex, a fearful dystopia—“inferior hypertext”—a hopeful utopia—Xanadu—and utter secrecy. Just six dudes in a rented house near Philly, building the internet, hiding from the Feds, signing NDAs, and saving the world. Nelson spent a summer explaining the project to his team in its entirety. By the end, Gregory, Miller, and Greene were the only ones left. They told Nelson, “We’ll do it,” and moved to another suburb, where they finally began to work on an implementation of Xanadu. The three quickly figured out a new system that would allow users to reference and link to specific parts of a file—they called these links tumblers, and made them work with transfinite numbers. Suddenly, transclusions were really possible. But after only a few early successes, the team’s progress stalled completely. Greene and Miller were young and left for jobs elsewhere, and so Gregory was left working on Xanadu alone. Nelson, meanwhile, ran a magazine called Creative Computing for a while, then tried again to build his JOT word processor—this time for the Apple II—then spent a year in San Antonio pitching a watered-down version of Xanadu (rebranded as “Vortext”) to a tech company called Datapoint. Datapoint wasn’t buying, but kept Nelson on in some sort of fake, primitive email job anyway. Gregory kept working on Xanadu in Philadelphia, slowly running out of money. Ted Nelson held an “Ecstasy party” in San Antonio: “A number of us floated down the river on inner tubes. It was quite lovely.” In 1987, like he did every year, Roger Gregory went to The Hackers Conference in Saratoga to show off the latest unimpressive version of Xanadu. There, he met a man named John Walker—founder of the wildly successful Autodesk—and pitched the project to him. Incredibly, Walker was interested, and after tense negotiations with Nelson, agreed to fund Xanadu in earnest. Beginning in 1988, Autodesk poured millions of dollars into the project, and a programming team led by Gregory finally started to make real progress. Walker said of Xanadu: “In 1980, it was the shared goal of a small group of brilliant technologists. By 1989, it will be a product. And by 1995, it will begin to change the world.” Sweeping rhetoric—clear deadlines. The team came nowhere close to meeting them. Infighting broke out between two factions—while Gregory simply wanted to patch together his old C code, insisting his product “was within six months of shipping,” the whiz-kid Mark Miller came back from his new job at Xerox PARC, alongside a half-dozen of his closest friends, and insisted on a perfectionistic rewrite in a more flexible language, Smalltalk. The PARC faction began to drive Gregory up the wall. According to Nelson, it got to the point that he “was throwing things and acting crazy.” So Nelson called John Walker, the two “summoned Roger to meet [them] at John’s house at Muir Beach, and Walker told Roger he was no longer in charge.” Miller took over and began the rewrite in Smalltalk. Walker’s deadline came and went, and the team delivered nothing. Xanadu’s offices descended into chaos—Miller anointed two PARC programmers to be “co-architects,” and the three of them increasingly left the rest of the team out of the loop. For four years, Miller dawdled about, adding features, giving them clever names (files were “berts,” after Bertrand Russell, and so, for symmetry’s sake, royalty-generating transclusions became “ernies”), and never building them.9 Meanwhile, Ted Nelson was living on a houseboat, attending sex retreats and Keristan orgies, and giving talks in Singapore. He recorded a new soundtrack for his student film, the one from 1959. In 1992, Autodesk’s stock cratered, and they divested entirely from Xanadu. Miller lamented that his program was just six months from completion. Ted Nelson started a film studio to make a movie with Doug Engelbart, then left for Japan to get a PhD. Xanadu’s code was open-sourced in the late 90s. 6. The World Wide Web In March 1989, a British computer scientist named Tim Berners-Lee, working at CERN, wrote a proposal for a system unifying hypertext and the internet. It was ignored. In 1990, Berners-Lee resubmitted his proposal, it was accepted, and he began to work on the World Wide Web. The WWW had a number of advantages over Xanadu: It was much simpler—Ted Nelson wrote of it disparagingly: “Where were annotation and marginal notes? Where was version management? Where was rights management? Where were multi-ended links? Where were third-party links? Where were transclusions? This ‘World Wide Web’ was just a lame text format and a lot of connected directories.” As it turns out, it’s much easier to build a lame text format and a lot of connected directories!

Inline links: 8, 9, Keristan

October 28, 2025 · Original source

…with Rixi Moncada (socialist), Salvador Nasralla (liberal), and Nasry Zablah (right-wing) all making strong showings. My impression is Moncada would be worst for Prospera, Zablah best, and Nasralla somewhere in the middle. Meanwhile, my contact in Prospera reports that life in the city continues as normal, with most residents relatively insulated from the lawfare happening around them. They are up to 300 registered companies, a nearly-full office tower, a few residential developments under construction, and frequent conferences on relevant topics like crypto and biotech. From Techbro To Sherbro Sherbro, Sierra Leone. A place synonymous in the popular imagination with the phrase “Sherbro, Sierra Leone”. Population 30,000. Size 230 square miles (or “just a little bit smaller than Singapore”, according to its boosters). There are too many places named “Freetown”. And not enough named “Kissidougou”. Siaka Stevens is the grandson of Sierra Leone’s first president, also named Siaka Stevens. He grew up in Britain, worked in business and finance, then went back to his family homeland as an adult. Moved by the poverty he saw around him, he decided to start a charter city. He recruited the help of Idris Elba, a famous British actor of Sierra Leonean descent, and together they started a company to build Sherbro Island City. The usual Dubai and Singapore comparisons were made. Maybe due to Stevens’ government connections, they got an impressively broad concession from the government - the Charter Cities Institute has compared it to Honduras’ ZEDEs, among the most autonomous charter city legislation in the world. From the podcast: Okay, so there are seven governing board members and the agreement specifically states that they are strictly from the private sector. SAP, our company, will choose four of the board members and the chairperson and the government of Sierra Leone will choose three. That’s the seven member board. And underneath that is a similar structure to municipal corporation. We have fiscal and legislative autonomy. English common law, very robust investor protections. The best way to kind of describe it, a similar situation, mean, Hong Kong now actually, and it’s a similar setup to Hong Kong and China’s relationship in the early eighties, where you have a special administrative region that is very autonomous, but sovereignty is held by the main Sierra Leone country. So it’s an innovative kind of new system of governance. Stevens calls the island a “greenfield” site, but it includes a town (Bonthe, population ~10,000) and an ethnic group (the Sherbro people). Yup, that’s definitely an ethnic group. I have honestly never seen a group this ethnic before. A+ at being ethnic (source). It’s slightly unclear whether Bonthe and other inhabited areas are within the SEZ, but it looks like maybe they are, and Stevens means he will mostly be building the new Singapore-style smart city on uninhabited parts of the island, with Bonthe as an early base for transit and development that he hopes will benefit but otherwise remain unaffected. Various local chiefs seem to be mostly in favor, as far as we know. The big problem for these island charter city attempts is infrastructure. You eventually want heavy industry and high-value-add manufacturing, but how do you build up enough civilization - transit, power, labor, amenities - to support these expensive enterprises? Every charter city has its own solution - gambling in Grand Bahama, regulatory arbitrage in Prospera, political alignment in Praxis. Sherbro’s plans include: A hub to lure the Sierra Leone diaspora back to the country (Google says the Sierra Leone diaspora is 336,000 people, most of whom are probably not digital nomads or jet-setters)

Inline links: https://substackcdn.com/image/fetch/$s_!UMhi!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fd5972e52-4f45-41ea-a520-a17cd78b7d8d_762x721.png, Sherbro Island City, the podcast, https://substackcdn.com/image/fetch/$s_!w7Zj!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fb01bfbd8-7896-4274-946e-fe0659c9cd5a_920x613.jpeg, source

There are too many places named “Freetown”. And not enough named “Kissidougou”. Siaka Stevens is the grandson of Sierra Leone’s first president, also named Siaka Stevens. He grew up in Britain, worked in business and finance, then went back to his family homeland as an adult. Moved by the poverty he saw around him, he decided to start a charter city. He recruited the help of Idris Elba, a famous British actor of Sierra Leonean descent, and together they started a company to build Sherbro Island City. The usual Dubai and Singapore comparisons were made. Maybe due to Stevens’ government connections, they got an impressively broad concession from the government - the Charter Cities Institute has compared it to Honduras’ ZEDEs, among the most autonomous charter city legislation in the world. From the podcast: Okay, so there are seven governing board members and the agreement specifically states that they are strictly from the private sector. SAP, our company, will choose four of the board members and the chairperson and the government of Sierra Leone will choose three. That’s the seven member board. And underneath that is a similar structure to municipal corporation. We have fiscal and legislative autonomy. English common law, very robust investor protections. The best way to kind of describe it, a similar situation, mean, Hong Kong now actually, and it’s a similar setup to Hong Kong and China’s relationship in the early eighties, where you have a special administrative region that is very autonomous, but sovereignty is held by the main Sierra Leone country. So it’s an innovative kind of new system of governance. Stevens calls the island a “greenfield” site, but it includes a town (Bonthe, population ~10,000) and an ethnic group (the Sherbro people). Yup, that’s definitely an ethnic group. I have honestly never seen a group this ethnic before. A+ at being ethnic (source). It’s slightly unclear whether Bonthe and other inhabited areas are within the SEZ, but it looks like maybe they are, and Stevens means he will mostly be building the new Singapore-style smart city on uninhabited parts of the island, with Bonthe as an early base for transit and development that he hopes will benefit but otherwise remain unaffected. Various local chiefs seem to be mostly in favor, as far as we know. The big problem for these island charter city attempts is infrastructure. You eventually want heavy industry and high-value-add manufacturing, but how do you build up enough civilization - transit, power, labor, amenities - to support these expensive enterprises? Every charter city has its own solution - gambling in Grand Bahama, regulatory arbitrage in Prospera, political alignment in Praxis. Sherbro’s plans include: A hub to lure the Sierra Leone diaspora back to the country (Google says the Sierra Leone diaspora is 336,000 people, most of whom are probably not digital nomads or jet-setters)

Inline links: Sherbro Island City, the podcast, https://substackcdn.com/image/fetch/$s_!w7Zj!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fb01bfbd8-7896-4274-946e-fe0659c9cd5a_920x613.jpeg, source

Yup, that’s definitely an ethnic group. I have honestly never seen a group this ethnic before. A+ at being ethnic (source). It’s slightly unclear whether Bonthe and other inhabited areas are within the SEZ, but it looks like maybe they are, and Stevens means he will mostly be building the new Singapore-style smart city on uninhabited parts of the island, with Bonthe as an early base for transit and development that he hopes will benefit but otherwise remain unaffected. Various local chiefs seem to be mostly in favor, as far as we know. The big problem for these island charter city attempts is infrastructure. You eventually want heavy industry and high-value-add manufacturing, but how do you build up enough civilization - transit, power, labor, amenities - to support these expensive enterprises? Every charter city has its own solution - gambling in Grand Bahama, regulatory arbitrage in Prospera, political alignment in Praxis. Sherbro’s plans include: A hub to lure the Sierra Leone diaspora back to the country (Google says the Sierra Leone diaspora is 336,000 people, most of whom are probably not digital nomads or jet-setters)

Inline links: source

Why AI Safety Won't Make America Lose The Race With China

November 26, 2025 · Original source

In 2023, the US realized it was in an AI race with China and slashed chip exports. Chinese access to compute dropped dramatically. They began accelerating onshore chip development, but this will take a decade or more to pay off. For now, the Chinese AIs you’ve heard of - DeepSeek, Kimi, etc - are primarily trained on a combination of stockpiled American chips from before the export controls, and American chips smuggled in through third parties, especially Singapore and Malaysia.

If the US knows about Chinese chip smuggling strategies, why can’t it crack down? The main barriers are a combination of corporate lobbying and poor funding. That is, chip companies want to continue to sell to Singapore and Malaysia without too many awkward questions about where the chips end up. And the Bureau of Industry and Security, the government department charged with countering smuggling, gets about $50 million/year to spend on chips, which experts say is not enough to plug all the holes. To put that number in context, Mark Zuckerberg recently made job offers as high as $1 billion per AI researcher. If America cared about winning the race against China even a tenth as much as Mark Zuckerberg cares about winning the race against OpenAI, we would be in a much better position!

Meetups Everywhere Spring 2026: Times & Places

April 01, 2026 · Original source

Contact: Steve Kuhn Contact Info: steve[@]sportspredict[.]com Time: Thursday, April 23rd, 1:00 PM Location: Thie High Street Lounge, Shangri La Hotel, BGC, Manila Coordinates: https://plus.codes/7Q63H22W+XP Singapore SINGAPORE Contact: Srijita Contact Info: srijitak[.]cmi[@]gmail[.]com Time: Sunday, May 10th, 3:15 PM Location: Myx at Holland Village Coordinates: https://plus.codes/6PH58Q6W+QQ Group Link: Two groups, one at https://www.lesswrong.com/groups/N42bMYFJBBRpkzKqX and one at https://t.me/LessWrong_Singapore Notes: Preferrably RSVP on LessWrong if you’re coming. The reservation at MyX is till 5:30 pm, and I will cover snacks till then. If you’re planning to stay for dinner as well (I am), please email me so I can extend the reservation. Dinner will be at your own expense.

Inline links: https://plus.codes/7Q63H22W+XP, https://plus.codes/6PH58Q6W+QQ, https://www.lesswrong.com/groups/N42bMYFJBBRpkzKqX, https://t.me/LessWrong_Singapore

Contact: Srijita Contact Info: srijitak[.]cmi[@]gmail[.]com Time: Sunday, May 10th, 3:15 PM Location: Myx at Holland Village Coordinates: https://plus.codes/6PH58Q6W+QQ Group Link: Two groups, one at https://www.lesswrong.com/groups/N42bMYFJBBRpkzKqX and one at https://t.me/LessWrong_Singapore Notes: Preferrably RSVP on LessWrong if you’re coming. The reservation at MyX is till 5:30 pm, and I will cover snacks till then. If you’re planning to stay for dinner as well (I am), please email me so I can extend the reservation. Dinner will be at your own expense.

Inline links: https://plus.codes/6PH58Q6W+QQ, https://www.lesswrong.com/groups/N42bMYFJBBRpkzKqX, https://t.me/LessWrong_Singapore

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Astral Codex Ten

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