nicotinamide mononucleotide
Article
nicotinamide mononucleotide is a recurring concept in the Astral Codex Ten archive, appearing 2 times across 2 issues between April 28, 2021 and April 13, 2022. The archive places it in contexts such as “The most-stuck-with nootropic was nicotinamide mononucleotide, a substance which is supposed to delay aging”; “nicotinamide mononucleotide supplementation can rewind the epigenetic clock”. It most often appears alongside South Africa, 2020 SSC nootropics survey, 852.
Metadata
- Category: Concepts
- Mention count: 2
- Issue count: 2
- First seen: April 28, 2021
- Last seen: April 13, 2022
Appears In
Related Pages
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- South Africa (2 shared issues)
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- 2020 SSC nootropics survey (1 shared issues)
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- 852 (1 shared issues)
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- acetaminophen (1 shared issues)
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- ADHD (1 shared issues)
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- Arthur Jensen (1 shared issues)
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- ASD (1 shared issues)
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- Bernier 2017 (1 shared issues)
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- Biodeterminist’s Guide To Parenting (1 shared issues)
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- Bolduc 2016 (1 shared issues)
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- BuyModa (1 shared issues)
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- Caudill 2018 (1 shared issues)
External Links
Source Context
Recovered passages from the original issue text. When the raw archive preserved outbound links inside the source passage, they are listed directly under the quote.
The most-stuck-with nootropic was nicotinamide mononucleotide, a substance which is supposed to delay aging if you take it every day indefinitely.
David Sinclair claims that nicotinamide mononucleotide supplementation can rewind the epigenetic clock. Would this reverse paternal age effects? I think no, for two reasons. First, paternal age effects are more likely to be because of genetic damage than epigenetic damage. Second, in the one mouse experiment where they tried this, NMN “reduced sperm count, vitality and increased sperm oxidative DNA damage, which was associated with increased NAD+ in testes”, though not consistently.