Astral Codex Ten

ASD

4 min read

ASD

Article

ASD is a recurring concept in the Astral Codex Ten archive, appearing 2 times across 2 issues between February 03, 2022 and April 13, 2022. The archive places it in contexts such as “neurodevelopmental disorders of ASD, ADHD, and OCD”; “cord biomarkers of fetal exposure to acetaminophen were associated with significantly increased risk of childhood ADHD and ASD”. It most often appears alongside ADHD, Elon Musk, Ivy League.

Metadata

  • Category: Concepts
  • Mention count: 2
  • Issue count: 2
  • First seen: February 03, 2022
  • Last seen: April 13, 2022

Appears In

Source Context

Recovered passages from the original issue text. When the raw archive preserved outbound links inside the source passage, they are listed directly under the quote.

ACX Grants ++: The First Half
February 03, 2022 · Original source
#25: Scientific Research On Life History Models Of Mental Illness I'm J.D. Haltigan and I'm looking for funding to continue independent scientific research with my academic colleague investigating life-history models of psychopathology as they relate to the neurodevelopmental disorders of ASD, ADHD, and OCD. In order to optimally continue this work amidst the pandemic, funding that would allow us the potential of release from other academic duties (e.g., teaching, grant writing) would help advance this work which is pre-registered and described here: https://aspredicted.org/blind.php?x=2ea9vn. Currently I am seeking 5k USD and am happy to hold a Zoom call with anyone who who can provide funding or advice to provide further details on the project as well as my academic background and credentials. [You can reach me at jhaltiga@gmail.com]
Obscure Pregnancy Interventions: Much More Than You Wanted To Know
April 13, 2022 · Original source
A small but statistically significant association between advancing paternal age and risk of autism spectrum disorder (ASD) has also been observed [101-106]. As an example, a dose-response meta-analysis of 27 observational studies reported that a 10-year increase in paternal age resulted in a 21 percent increased risk of autism in the child [107]. A study of over 14,000 Dutch patients reported that, compared with fathers under age 20, males over age 40 who father children were 3.3 times as likely to have a child affected with ASD [108]. Another study in Israel, which drew data from over 130,000 couples, reported that, compared with fathers under age 30, males over the age of 40 were 5.75 times as likely to have an offspring with ASD [101]. This may be related to de novo spontaneous mutations and/or alterations in genetic imprinting.
Inline links: 101-106, 107, 108, 101
Other studies ask women how much Tylenol they took when they were pregnant, then try to correlate it with offspring outcomes. The Consensus Statement lists 29 of these studies, and says 26 / 29 found evidence of harm. A typical study is Chen 2018, where researchers identify 950 kids with ADHD and 3800 kids without, and compare (using health system records) how likely their mothers were to have used Tylenol (finding that the ADHD moms were about 25% more likely). Even more sophisticated is Ji 2020, which found that “[umbilical] cord biomarkers of fetal exposure to acetaminophen were associated with significantly increased risk of childhood ADHD and ASD in a dose-response fashion.”
Inline links: Chen 2018, Ji 2020