Open Philanthropy

Article

Open Philanthropy is a recurring organization in the Astral Codex Ten archive, appearing 19 times across 19 issues between May 04, 2022 and April 06, 2026. The archive places it in contexts such as “Not Open Philanthropy or Future Fund or any of those people”; “Open Philanthropy analyzes their past predictions”; “received a further $1.6 million from Open Philanthropy”. It most often appears alongside China, Twitter, US.

Metadata

• Category: Organizations
• Mention count: 19
• Issue count: 19
• First seen: May 04, 2022
• Last seen: April 06, 2026

Appears In

• Every Bay Area House Party
• Links For June
• ACX Grants: Project Updates
• Open Thread 270
• Davidson On Takeoff Speeds
• Tales Of Takeover In CCF-World
• In Continued Defense Of Effective Altruism
• Links For November 2023
• 24
• Open Thread 340
• Links For November 2024
• Open Thread 368
• Lives Of The Rationalist Saints
• ACX Grants 1-3 Year Updates
• Open Thread 402
• Open Thread 408
• Open Thread 409
• Links For December 2025
• Open Thread 428

Related Pages

• • China (7 shared issues)
• • Twitter (7 shared issues)
• • US (7 shared issues)
• • Anthropic (6 shared issues)
• • OpenAI (6 shared issues)
• • ACX (5 shared issues)
• • Metaculus (5 shared issues)
• • Substack (5 shared issues)
• • Astralcodexten Com (4 shared issues)
• • California (4 shared issues)
• • Manifold (4 shared issues)
• • Manifold Markets (4 shared issues)

External Links

• • http://openphilanthropy.org
• • http://web.archive.org/web/20221104130431/https://stevekirsch.substack.com/p/1m-bet-rules
• • http://web.archive.org/web/20221129133112/https://blog.rootclaim.com/rootclaim-accepts-500000-challenge-on-covid-vaccine-safety-efficacy/
• • http://web.archive.org/web/20221224061743/https://www.skirsch.com/covid/SaarWilf.pdf
• • https://archive.ph/pY4gF#selection-663.103-683.190
• • https://astralcodexten.substack.com/p/biological-anchors-a-trick-that-might
• • https://astralcodexten.substack.com/p/motivated-reasoning-as-mis-applied/comment/4817922
• • https://coefficientgiving.org/research/open-philanthropy-is-now-coefficient-giving/
• • https://en.wikipedia.org/wiki/Open_Philanthropy
• • https://forum.effectivealtruism.org/posts/h2N9qEbvQ6RHABcae/a-critical-review-of-open-philanthropy-s-bet-on-criminal
• • https://manifund.org/rounds/ai-worldviews?tab=about
• • https://web.archive.org/web/20230104080248/https://www.rootclaim.com/

Source Context

Recovered passages from the original issue text. When the raw archive preserved outbound links inside the source passage, they are listed directly under the quote.

Every Bay Area House Party

May 04, 2022 · Original source

“Not Open Philanthropy or Future Fund or any of those people, but I was able to get independent funding.”

Links For June

July 01, 2022 · Original source

25: Open Philanthropy analyzes their past predictions about how their grants would do. Conclusion: their calibration is great, their accuracy is better than chance but not super impressive.

Inline links: analyzes their past predictions

ACX Grants: Project Updates

November 04, 2022 · Original source

11: Develop Oxfendazole As A New Deworming Medication (10/10) The Oxfendazole Development Group has received a further $1.6 million from Open Philanthropy. They have completed several studies on metabolites and drug interactions, and are working on more. It is still early in the approval process but they are optimistic. They are looking for further funding to better characterize the physical/chemical properties of oxfendazole; contact here if you are able to help.

Inline links: here

One thing that may systematically have gone better than expected: just after my grants program, the rationalist/effective altruist community got a sudden influx of money as FTX Future Fund experimented with new ways to spend their billions of dollars. Several of the projects I gave grants to later got much bigger grants from FXTFF (plus one from Open Philanthropy) - I hope that my work signal-boosting and validating them was able to contribute to that in some way. This may have been the most important result of this grants program, since it moved more money than I did!

Open Thread 270

April 03, 2023 · Original source

4: Last month I teamed up with Manifold to run an impact market on forecasting grants. Now Manifold is using their impact market infrastructure, Manifund, to start a market in prizes on Open Philanthropy’s AI-related essay contest. The idea is - you write an essay and submit it in hopes of winning (let’s say) the $50,000 first prize. Then you sell the right to the prize on the impact market - for example if you think you’re 10% likely to win (so your essay is worth $5,000) and someone else thinks you’re 20% likely to win (so your essay is worth $10,000), then you could sell the rights to the prize money to them for $7,500 (it’s a bit more complicated than that, but you get the idea). I’m not directly involved in this one, but I trust Manifold a lot and this should help them develop their impact market work further. Yes, you still have to be an accredited investor to buy certificates (though not to sell your essay!). Go here for more information. I guess this doubles as an announcement that there’s an AI-related essay contest with a first prize of $50,000. Entries are due May 31 - no, they won’t find it funny if you use GPT.

Inline links: Open Philanthropy’s AI-related essay contest

Davidson On Takeoff Speeds

June 20, 2023 · Original source

Last year I wrote about Open Philanthropy’s Biological Anchors, a math-heavy model of when AI might arrive. It calculated how fast the amount of compute available for AI training runs was increasing, how much compute a human-level AI might take, and estimated when we might get human level AI (originally ~2050; an update says ~2040)

Inline links: I wrote about Open Philanthropy’s Biological Anchors, an update

A lot of these big complicated analyses are salvos in a long-running conflict between a school of futurists based at Open Philanthropy and another school based at the Machine Intelligence Research Institute.

Davidson works at Open Philanthropy and is trying to flesh out their side of the story. Again, even his “gradual” takeoff won’t seem very gradual to us fleshbag humans; it will go from 20% of the economy to 100% in ~3 years, and reach superintelligence within a year after that9. Still, there will at least be enough time for journalists to publish a few articles saying that fears of AI taking over 100% of the economy are overblown and alarmist, which is a sort of gradual.

Inline links: 9

Tales Of Takeover In CCF-World

July 03, 2023 · Original source

I mentioned earlier that the CCF report comes out of Open Philanthropy’s school of futurism, which differs from the Yudkowsky school where a superintelligent AI quickly takes over. Open Philanthropy is less explicitly apocalyptic than Yudkowsky, but they have concerns of their own about the future of humanity.

In Continued Defense Of Effective Altruism

November 28, 2023 · Original source

Open Philanthropy Project originally got one seat on the OpenAI board by supporting them when they were still a nonprofit; that later went to Helen Toner. I’m not sure how Tasha McCauley got her seat. Currently the provisional board is Bret Taylor, Adam D’Angelo, and Larry Summers. Summers says he “believe[s] in effective altruism” but doesn’t seem AI-risk-pilled. Adam D’Angelo has never explicitly identified with EA or the AI risk movement but seems to have sided with the EAs in the recent fight so I’m not sure how to count him.

See here, Open Philanthropy is first-listed funder. Leader Kevin Esvelt has spoken at EA Global conferences and on 80,000 Hours

Inline links: here, EA Global conferences, 80,000 Hours

Open Philanthropy’s Wikipedia page says it was “the first institutional funder for the YIMBY movement”. The Inside Philanthropy website says that “on the national level, Open Philanthropy is one of the few major grantmakers that has offered the YIMBY movement full-throated support.” Open Phil started giving money to YIMBY causes in 2015, and has donated about $5 million, a significant fraction of its total funding.

Inline links: Open Philanthropy’s Wikipedia page, says

Links For November 2023

December 01, 2023 · Original source

12: Open Philanthropy discusses its decision to donate $300 million to GiveWell’s top charities, including fascinating lines like this:

Inline links: discusses its decision

We’ve reduced the annual rate of our funding for GiveWell’s recommendations because our “bar” for funding in our Global Health and Wellbeing (GHW) portfolio has risen substantially. In July 2022, it was roughly in the range of 1100x-1200x; we recently raised it to slightly over 2000x. That means we need to be averting a DALY for ~$50 (because we value DALYs at $100K) or increasing income for 4 people by ~1% for a year for $1 (because we use a logarithmic utility function anchored at $50K).

Inline links: our “bar” for funding, portfolio, 1100x-1200x, DALY, we value DALYs at $100K, we use a logarithmic utility function anchored at $50K

24

May 13, 2024 · Original source

People changed their minds a little over time, but not in a very consistent way that mattered much in the end. What was the “client feedback”? The report says: Client feedback was provided to the Superforecasters on December 21. The client posed questions to the Superforecasters about their assessments up to that date and asked for their reactions to several studies and articles. In the days following the client engagement, the Superforecasters lowered their confidence in the natural zoonosis hypothesis from 73% to 67%, although zoonosis remained the most likely potential cause in their assessment. But following an active engagement with recent genomic studies and historical base rates of zoonotic spillovers, those numbers began to return to earlier levels. January also saw increased attention to the geopolitical context and transparency issues, particularly related to research activities in Wuhan Is this bad? I’m imagining a pro-lab-leak client saying “But what about [this list of pro-lab-leak arguments]?” and then the superforecasters read them and adjust. In one sense, it’s good that they got to see more arguments; on the other, it seems like a potential route by which clients could bias the results - probabilities never quite got back to where they were before the feedback, though they got pretty close. The last-minute spike for zoonosis might be the Rootclaim debate results, which were released on 2/18. So maybe the client feedback and the Rootclaim results both slightly affected the numbers, but mostly the superforecasters started out pro-zoonosis and stuck to their guns. Dan Schwarz and the FutureSearch team say that forecasting has a “rationale-shaped hole”. Despite the report making this sound like a pretty intense process, we don’t get much information about details: In their extensive discussions , Good Judgment’s Superforecasters assessed base rates and historical patterns, existing evidence and scientific analysis, geopolitical context and transparency concerns, trust in intelligence communities, and methodological constraints. 1. Base Rates and Historical Patterns: The Superforecasters frequently referenced base rates, i.e., the history of pandemics emerging from natural zoonosis versus the history of laboratory leaks, to anchor their probabilities. For the former, they discussed how the base rates are changing as the climate warms and as expanding human populations push farther into natural environments that previously saw little human presence. For the latter, they acknowledged that it has only been 12 years since the advent of CRISPR gene- editing tools, and the base rate of lab leaks in the short synthetic biology era is not yet well established. 2. New Evidence and Scientific Analysis: Throughout the period, the Superforecasters adapted their forecasts in light of new scientific evidence, including genomic analyses of SARS-CoV-2 and its relation to bat viruses, and the debate over potential laboratory manipulation. 3. Geopolitical Context and Transparency Concerns: The geopolitical implications of the virus’s origins, particularly in relation to China’s transparency and the involvement of international research institutions, played a significant role in the analysis. Concerns over data veracity, and over the political ramifications of determining that the pandemic’s origins were other than zoonosis, were extensively debated. 4. Trust in Intelligence: Commentary on trust in intelligence communities and discussions about the impact of geopolitical biases on the interpretation of evidence illustrated the complex interplay between science, politics, and human behavior in assessing the pandemic’s origins. 5. Methodological Critiques and the Evaluation of Evidence: The Superforecasters engaged in methodological critiques of the evidence base, including the scrutiny of laboratory practices and biocontainment levels [...] In the end, most Superforecasters were in rough agreement on issues like the base rates of zoonotic spillover. Where they most often disagreed was on the interpretation of actions by Chinese officials and whether their actions reflected how an authoritarian government would react in any crisis over which it did not have full control, or whether those actions were indicative of attempts to cover up a biomedical research-related accident that allowed the SARS-CoV-2 virus to enter circulation in China and, ultimately, the entire globe. Probably it would be too much to ask for to get a transcript of all their discussions - then they’d be nervous saying things that might make them look bad to an audience. What would be a good balance between getting more information and not imposing on their time? Forecasting is an unusually legible and easy-to-judge domain. One of the theories of change for forecasting was to use it to identify smart people with good reasoning, then turn them loose on less well-behaved problems. This is one of the first big attempts to do this at scale. How did it work? We can’t tell, because it’s inherently an illegible and hard-to-judge domain. Darn. I don’t know what I expected. Notes From A Local Optimum Austin’s concern - that forecasting has reached a local optimum - is widely shared. We have some good sites: Manifold, Metaculus, Polymarket, GJO, etc - all doing good work. We have good-ish probabilities for a few important questions. Every so often a news source cites them. Sometimes a decision-maker looks at them behind the scenes, maybe. Is this all there is? The FutureSearch team says the next step is to focus on “rationale”. We need to use forecasting not just to get a raw probability, but to explain what’s going on and why we think something. Then instead of just convincing policy-makers to trust forecasts, we can tell them why something is true, or inform their discussions even if they’re not willing to blindly trust a number. Is this a betrayal of the forecasting ethos? The original dream was that instead of a bunch of people giving arguments, we could just test who was right. Now we’re going back to the arguments? People have argued forever; what does forecasting add to that? Well, they add the knowledge that the arguments are from people who have been right a lot before and are incentivized to be right again. Still, it’s not a natural fit. Probably it’s relevant here that FutureSearch’s forecasting AI does a really good job of this by default, in a way humans can’t match. Nuno’s yearly forecasting roundup doesn’t have a single thesis, but the first part is a well-supported complaint that most forecasting sites aren’t good business. They either burn VC money, burn EA donations, or converge towards casinos to support themselves. He gives an honorable exception to Cultivate Labs, which sells prediction market software rather than the results themselves. Open Philanthropy (billionaire Dustin Moskovitz’s EA-aligned charitable foundation) has at least given forecasting a vote of confidence, recently choosing to promote it to one of their main donation areas. Still, they got a lot of pushback on the decision, for example SuperDuperForecasting here: This will be a total waste of time and money unless OpenPhil actually pushes the people it funds towards achieving real-world impact. The typical pattern in the past has been to launch yet another forecasting tournament to try to find better forecasts and forecasters. No one cares, we already know how to do this since at least 2012! The unsolved problem is translating the research into real-world impact. Does the Forecasting Research Institute have any actual commercial paying clients? What is Metaculus's revenue from actual clients rather than grants? Who are they working with and where is the evidence that they are helping high-stakes decision makers improve their thought processes? Incidentally, I note that forecasting is not actually successful even within EA at changing anything: superforecasters are generally far more relaxed about Xrisk than the median EA, but has this made any kind of difference to how EA spends its money? It seems very unlikely. And Marcus Abramovich here: I'm in the process of writing up my thoughts on forecasting in general and particularly EA's reverence for forecasting but I feel, similar to @Grayden that forecasting is a game that is nearly perfectly designed to distract EAs from useful things. It's a combination of winning, being right when others are wrong and seemingly useful, all wrapped into a fun game. I'd like to see tangible benefits to more broad funding of forecasting that seems to be done in t he millions and tens of millions of dollars. I would also be the type of person you would think would be a greater fan of forecasting. I'm the number one forecaster on Manifold and I've made tens of thousands of dollars on Polymarket. But I think we should start to think of forecasting as more of a game that EAs like to play, something like Magic the Gathering that is fun and has some relations to useful things but isn't really useful by itself. Eli Lifland has a long and hard-to-summarize comment here, response from Ozzie Gooen here, podcast between them on “Is Forecasting A Promising EA Cause Area?” here. I’m split on this. My previous hope was that the field would gradually grow, without any qualitative changes or discontinuities, until it became big enough that journalists and policy-makers were aware of it and took it seriously (compare eg the growth of the Internet as a scholarly resource). I think the strongest argument against this is Manifold’s relatively flat user numbers. Is there a new hope? I think if nothing else, forecasting might be useful as a testing ground: First, to create forecasting AIs (like FutureSearch) which can then get consulted on a variety of questions, eg by policy-makers. The biggest holdup has always been the need to gather 20 or 50 or however many hard-to-find superforecasters for whatever question you’re asking, and then trust their advice even though they’re fallible fleshbag humans. If you can use the 20 to 50 superforecasters to inspire an AI, and then test the AI and prove it’s good, people might be more interested. This is especially true if the AI can branch out beyond traditional forecasting questions. Once we have a few of these, we can start comparing the next generation of AIs to the previous generation, and skip the superforecasters.

Inline links: forecasting has a “rationale-shaped hole”, Nuno’s yearly forecasting roundup, Cultivate Labs, choosing to promote it to one of their main donation areas, here, superforecasters are generally far more relaxed about Xrisk, here, @Grayden, here, here, “Is Forecasting A Promising EA Cause Area?” here

Open Thread 340

July 29, 2024 · Original source

1: Open Philanthropy (a major AI safety funder) is accepting grant applications relating to technical alignment, policy, law, et cetera.

Inline links: accepting grant applications

Links For November 2024

November 01, 2024 · Original source

This was before they invented what we would call antidepressants today; Dexedrine is an amphetamine related to Adderall. 24: Congratulations to Open Philanthropy, the biggest effective altruist foundation… …whose grantee David Baker recently won a Nobel Prize for his research on synthetic proteins. Potential applications include new drugs, vaccines, and materials. 25: Rich Kid Memes And The Online Culture Of The One Percent. Rich people who want to signal group membership to other rich people online can’t boast about how rich they are; that would be gauche. Instead, they’ve settled on the solution of making fun of rich people in hyperspecific language that proves familiarity with the culture. 26: Tap Water Sommelier: Vladimir Putin has two sons, ages 5 and 9. They are kept in luxurious but total isolation from the outside world and raised by flunkies who are too scared to punish/restrain them in any way. Also some discussion of an unexpected historical analogue. 27: Experiment from Colombia: replacing experienced teachers with less-experience but higher-scoring-on-tests teachers significantly decreased student performance. Got to admit I was expecting the opposite of this, I’d seen US data saying that experience didn’t matter and teacher intelligence did. Looking over this more, I find lots of studies on both sides and will go back to agnosticism on this question until someone I trust investigates further. 28: Large scale-formal Intellectual Turing Test finds that people can imitate partisans effectively; ie nobody on either side can tell the difference between a Democrat arguing for Democrat values vs. a Republican-pretending-to-be-a-Democrat arguing for Democrat values (and vice versa). This study used a 100 word essay on why you supported your party (you can see if you can do better here), but past attempts with different structures (religion, vegetarianism, polyamory) have shown broadly the same results. The researchers try to put this in the context of various studies showing that people do misunderstand their opponents (eg think they’re more extreme, underestimate the level of common ground), but it seems like intellectual Turing Tests aren’t a good way to measure or tease out this misunderstanding. 29: Congratulations to Substacker WoolyAI for doing the impossible and providing a genuinely novel and interesting (to me) take on pickup artistry: 30: Did you know: if you Google “cool websites”, our subreddit (r/slatestarcodex) is the first result. 31: Moshe Koppel, who works at the intersection of computer science and Talmud, is writing a series of posts (presumably) based off of my Every Bay Area House Party, titled Jerusalem Area House Party (it’s multiple part, you have to go to the main Substack page to find the others). I won’t necessarily link everyone who riffs off one of my posts - but honestly I probably will if you also have a Wikipedia page that describes you as working on computational Talmudology. 32: David Roman says it’s a myth that Arabic scholars rescued and preserved the works of the great classical authors. 33: Medications often decrease “secondary endpoints” (eg stroke, heart attack), but the holy grail of pharma studies is proving that a certain drug decreases all-cause mortality. This is much harder (not all heart attacks kill people, and people die from lots of other things), but is the strongest possible endorsement for the drug (without it, you might worry that it only prevented non-fatal heart attacks, or that it killed as many people through side effects as it saves through heart attack prevention). Even great medications that we’re confident in can’t always clear this bar. But a new JAMA article adds another member to this select club: Adderall decreases all-cause mortality in ADHD, probably because it prevents drug addiction, car accidents, and impulsive actions. 34: Before the Gulf War got in the way, Saddam Hussein was building some crazy mosques: 35: Italy bans surrogacy - quite strictly, too, Italians aren’t even allowed to go abroad and do it. I am so sorry for all the Italians who will never get to be mothers and fathers because their government hates progress. You might hope that, whatever the other disadvantages of anti-immigrant parties, at least they’re incentivized to let natives have children, but looks like they can’t even get that one right. Starting to wonder whether the trains even run on time. 36: Elsewhere in “Italy sucks” news - did you know Italy’s tax code effectively bans startups? Companies are taxed before making any money, based on how many assets they have. If they have lots of assets but aren’t making money (eg because they’re still doing research / in stealth) then tax officials get confused and hostile and run increasingly punitive audits. Related: size of the European tech sector. It’s the red line on this chart; if you can’t see a red line at your screen resolution, then you’ve learned something important about the the EU tech sector. 37: Seen on @cremieuxrecuel’s twitter (preliminary, needs replication): Jews may have gone from 65-29 Democrat/Republican in 2020 to 58-40 this election. 38: Extelligence has a post responding to my critique of the cultural Christianity argument (among, uh, many other things), but I don’t really think it connects. I’m not telling atheists they can’t go to church/synagogue if it makes them feel happy and fulfilled - I’ve done this myself sometimes. My post was meant to argue against the claim that, for pragmatic reasons, atheists should support the Christianization of society as a defense against Islam or postmodernism or some other philosophical enemy. 39: Related: Extelligence is finally going for their Trust Assembly project/idea/startup for online consensus-based truth-seeking (I think something like a cross between Community Notes and Wikipedia, but as a browser extension, and for everything). He’s looking for potential developers/testers/users. 40: Jiankui He is the Chinese geneticist who made history with the first germline gene editing in humans (resulting in three babies supposedly immune to AIDS, although nobody has tested this). China sentenced him to three years in prison for unauthorized experimentation, but now he’s out of jail, has an English-language Twitter account, has a new lab, wants to work on Alzheimers, and seems pretty based (although not infinitely based): 41: Anthropic has a new version of their AI Claude which can use your computer. You give it permission, put it on a virtual desktop, and ask it to do things for you (eg “please find and download a picture of a cat” or “please research these ten things and put them in a text file”.) It moves your cursor, browses the Internet, and creates and saves files. People keep saying they’ll care about AI “when it operates autonomously” or “when it becomes an agent”. But this is a trivial barrier, and one which Computer Use Claude has arguably already passed. So far this feature is limited to developers (though anyone with computer knowledge can sign up for it) but I expect it to be the near future of consumer AI, to get better quickly, and to shade gradually into the “autonomous” “agentic” AI that you all think will require a paradigm shift. 42: Claim (from the IDF): Hamas faked polls showing that most Palestinians supported the October 7 attack; the real numbers are 31% in favor, 64% against. 43: Otto von Bismarck wanted to trick France into declaring war on Germany. In order to provoke the French, he sent the Ems Dispatch, a statement describing recent diplomatic events in a way that sounded maximally offensive. The French were so offended that “crowds” in Paris demanded war, and the Franco-Prussian War was declared soon afterwards. The part of this that I find most interesting is the text of the dispatch itself, which read: After the news of the renunciation of the Prince von Hohenzollern had been communicated to the Imperial French government by the Royal Spanish government, the French Ambassador in Ems made a further demand on His Majesty the King that he should authorize him to telegraph to Paris that His Majesty the King undertook for all time never again to give his assent should the Hohenzollerns once more take up their candidature. His Majesty the King thereupon refused to receive the Ambassador again and had the latter informed by the Adjutant of the day that His Majesty had no further communication to make to the Ambassador. I’m fascinated by the idea that only 150 years ago, it was obvious that if someone sent you this statement, you had to declare war or abandon all honor. If I read it carefully, I can sort of parse out that it sounds like the Prussians are unhappy, but that’s the most emotion I gather from it. Anyway, the Franco-Prussian War led to World War I which led to World War II - so if you don’t like 50 million people dying and the total devastation of Europe, blame this statement about ambassadors. 44: The first use of artificial insemination in humans: The first recorded case of artificial insemination by donor didn’t occur until 1884, when Dr. William Pancoast decided to treat a couple’s infertility by secretly inseminating the woman with sperm obtained from a medical student. The insemination happened while the patient was under anesthesia and Dr. Pancoast did not tell her what had occurred. She gave birth to a baby boy nine months later, but it was several years before the doctor finally confessed to her husband what he had done. Neither man ever informed the mother. It was 25 years later the result of this case was published. Dr. Pancoast was roundly condemned for his actions, but it did open the door for consensual sperm donor insemination. 45: ClearerThinking administers several personality tests to the same people to learn more about their comparative accuracy. I am most interested in their finding that tests with “factors” (eg the Big Five, where you rate people on a numeric scale) are inherently more accurate than those with “types” (eg Myers-Briggs, where you assign someone a specific category) and that, adjusting for this, Big Five is no more predictive than the Enneagram: 46: In 2022, I wrote Whither Tartaria, where I asked why ornate classical styles switched to more austere modernist styles around 1900 - 1950 in a variety of different arts (painting, architecture, literature, poetry, etc). I proposed seven theories, but was unsure which if any were true. Since then, Samuel Hughes of Works In Progress has been investigating. In May, he wrote a well-researched article showing that it wasn’t just increasing cost, because ornate classical architecture now costs less than ever. Now in a new article he demolishes a different theory - it’s not just decreasing cost (and subsequent lack of ability to signal wealth) - because costs didn’t decrease in several other arts, and the change was led by artists with rich people as reluctant followers. He concludes: Modernism may well be a status game of some kind; it may well signal taste more than it signals wealth; and this latter feature may be one of the things that distinguishes it from older artistic styles. But the mechanism by which this change came about must be different to the one Alexander describes. 47: Sort of kind of related - When Hamilton Lost Its Snob Appeal. The musical Hamilton was briefly an artistic/cultural phenomenon, but tastemakers eventually switched to making fun of it. Why? Rob Henderson says it happened after ticket prices came down and the common people could enjoy it. I disagree: everyone I knew who was into Hamilton got into it from the free online soundtrack long before they’d seen the show; I think this is more likely the usual fad cycle where anybody who’s too into yesterday’s fad is behind the curve and therefore uncool. 48: Related: Why are people such jerks to public intellectuals? And more. I agree this is a great mystery. 49: Some prominent Substack psychiatrists doing a video Q&A, submit your questions here. 50: Naomi Kanakia: The Literacy Delusion had a number of explanations for why reading books seemed to be so much worse for human beings (in terms of emotional wellness and productivity) than other forms of narrative entertainment, but its main theory was the integration hypothesis. That the stream of words in a book trained the human brain into a habit of self-consciousness, that reading books forced human beings to think of themselves as a stream of text, processed through time, making a coherent argument of some sort. And that this overall flattening effect forced readers to ignore aspects of their personality or their situation that were not otherwise in line with the overarching story they'd created about themselves. Basically, reading books causes repression and neurosis. The Literacy Delusion argued that, yes, human beings are storytelling machines, but that a stream of written text is a particular kind of story—a story that is particularly flat, particularly devoid of conflicting or harmonizing information—and that this flatness creates a peculiar effect on the human brain. 51: Last month, I linked Sasha Gusev’s No, Intelligence Is Not Like Height and asked people who disagreed to share their arguments; they sure did. First, several people pointed me to a new preprint, Family-GWAS Reveals Effects Of Environment And Mating On Genetic Associations, which finds that one of the main papers Gusev cited to make his case, Howe 2022, made a mistake - imputing sibling genotypes using a process designed for non-sibling genotypes - and that once that mistake is corrected, the finding disappears and intelligence and height appear similar. Second, Joseph Bronski has a more specific post where he responds to Gusev’s points one by one. He accuses Gusev of “[making] up his own chart to remove the error bars [from the originals], to obscure the fact that the study found no evidence for this in IQ”, and says that the cases where he didn’t do that are just “population stratification and range restriction”. Third, Noah Carl at Aporia, instead of writing a direct response like Bronski, argues that the usual method of attacking twin studies is obsolete; not only have the most-debated assumptions behind twin studies been thoroughly validated, but there are now other lines of evidence besides twin studies which confirm high IQ heritability. Fourth, Leonardo Parro (not framed as a response to Gusev) goes into more depth about one of those ways, a “pedigree-based analysis” demonstrating heritability of 54 - 69%, ie no “missing heritability” compared to twin studies. He summarizes this as the effect of “rare variants” compared to the usual SNPs - ie if you only look at the most common genes that are easiest to find, you get “missing heritability” compared to twin studies, but if you widen your search to rare genes that are hard to find, you don’t. 52: Extremely related: Heliospect is a startup promising polygenic selection for IQ and other traits; they were trying to stay in stealth mode but The Guardian spied on them and nonconsensually revealed their existence. The discussion on the r/ssc subreddit centered on their claim that (given enough embryos to choose from) they could increase a baby’s expected IQ by 6 points (I’ve also heard 7.5). Sasha Gusev had previously argued that current technology maxed out at 3.5 and future technology would max out at 6, so a claim of 6 - 7.5 is pretty extreme; Gwern, who wrote the pioneering analysis of this technology, was also skeptical. But Heliospect says they’ve got better predictors than academia that use the rare variants everyone else misses; after talking to the company, Gwern retracted his objections and says he finds their claim “pretty plausible”. Local ACX commenter geneticist Gene Smith also redid some calculations, changed his mind, and says “probably pretty realistic”. I find this interesting not just because of the polygenic selection angle, but because if Heliospect is right then their predictor is able to predict more genetic IQ than the “missing heritability” people believe exists, and it should be able to put this argument to bed once and for all. 53: This month in censorship: X/Twitter banned journalist Ken Klippenstein for sharing the Trump campaign’s dossier on JD Vance. Twitter’s side of the story is that the dossier was probably originally stolen by Iranian agents and they don’t want to support that kind of thing by letting people signal-boost the illicitly obtained goods; you can read Klippenstein’s side here. He appears to be unbanned now.

Inline links: https://x.com/albrgr/status/1844527064956928009, won a Nobel Prize, Rich Kid Memes And The Online Culture Of The One Percent, Tap Water Sommelier, Experiment from Colombia, experience didn’t matter, teacher intelligence did, Large scale-formal Intellectual Turing Test, you can see if you can do better here, religion, vegetarianism, polyamory, WoolyAI, https://substackcdn.com/image/fetch/$s_!4FRI!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F558ad67a-bfca-469e-abd8-2edc7c8b888a_590x916.png, if you Google “cool websites”, r/slatestarcodex, who works at the intersection of computer science and Talmud, Jerusalem Area House Party, says it’s a myth, Adderall decreases all-cause mortality in ADHD, some crazy mosques, https://substackcdn.com/image/fetch/$s_!2W0c!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fc2be0549-aa2b-411d-b6a6-da50c34f7f86_1000x572.jpeg, Italy bans surrogacy, Italy’s tax code effectively bans startups?, Related, https://substackcdn.com/image/fetch/$s_!T3h-!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F08b011b3-ef20-42e5-91b2-33946b8ca7b6_1761x1355.jpeg, @cremieuxrecuel, responding to my critique of the cultural Christianity argument, My post, is finally going for, Trust Assembly, has an English-language Twitter account, has a new lab, wants to work on Alzheimers, and seems pretty based, not infinitely based, https://substackcdn.com/image/fetch/$s_!fY_K!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F6b3b61c8-6c48-4eb7-9608-426b738ab9c8_592x111.png, which can use your computer, Claim, Ems Dispatch, The first use of artificial insemination in humans, administers several personality tests to the same people, https://substackcdn.com/image/fetch/$s_!epEc!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F47c474c6-d68a-41e4-954e-d24cd00ec040_740x388.webp, Whither Tartaria, a well-researched article showing, in a new article he demolishes a different theory, When Hamilton Lost Its Snob Appeal, Why are people such jerks to public intellectuals?, more, Some prominent Substack psychiatrists doing a video Q&A, submit your questions here, Naomi Kanakia, No, Intelligence Is Not Like Height, Family-GWAS Reveals Effects Of Environment And Mating On Genetic Associations, Howe 2022, a more specific post where he responds to Gusev’s points one by one, argues that the usual method of attacking twin studies is obsolete, goes into more depth about one of those ways, The Guardian spied on them and nonconsensually revealed their existence, discussion, previously argued, the pioneering analysis of this technology, Gwern retracted his objections, says, polygenic selection, banned journalist Ken Klippenstein, you can read Klippenstein’s side here., appears to be unbanned now

Open Thread 368

February 10, 2025 · Original source

2: Open Philanthropy asks me to let you know that they hope to distribute $40 million in new technical AI safety grants over the next five months. Example fields include interpretability, control, backdoors, unlearning, “LLM psychology”, and generalization, but they are also interested in potential new paradigms. If you have a relevant project, see their request for proposals here.

Inline links: request for proposals here

Lives Of The Rationalist Saints

February 20, 2025 · Original source

St. Avi the Greater fasted in the desert for thirty days, where he was tempted by Moloch. “Found a new AI lab,” said Moloch, “and I will make you powerful among men.” But Avi refused, saying “What use is power, if it only accelerates race dynamics?” Then Moloch continued: “Found a new AI lab, and I will make you a billionaire.” But Avi refused, saying “What use is money, when Open Philanthropy already has $20 billion and can’t find enough high-impact charities with room for more funding?” Then Moloch continued: “Found a new a AI lab, and I will give you all the kingdoms of the world.” But Avi refused, saying “I don’t even like the term ‘AI lab’ - that paints a picture of disinterested basic research that they don’t live up to. You can just say ‘AI company’.” Then Moloch howled, defeated, and Avi went on to found many highly-effective orgs.

ACX Grants 1-3 Year Updates

June 18, 2025 · Original source

Codebuff, an AI coding startup I probably can’t take full credit for all of this just from giving them $20K in seed funding, but I continue to appreciate everything they do for this community and the world. 35: Further S’s Political Career This person didn’t win their election, but has since pivoted to AI safety and works in a well-regarded AI policy think tank. 36: Seeds Of Science, A Journal Of Non-Traditional Research No update received, but this was a public journal and it is easy to follow their work, see their website and Substack. They published two dozen articles of widely varying quality through 2023 and 2024, then closed in 2025. A remnant of the original vision survives as a science blogging aggregator. This was about my median expectation for this grant, but it was very inexpensive and I decided to take a chance on it anyway. 37: Good Science Project, Working To Improve Federal Science Funding No update received, but they have a public Substack discussing their progress. Their proposals for NIH reform have influenced Congress and made government agencies pay more attention to scientific integrity. 38: Advising Developing Countries On How To Grow Their Economies With our initial ACX grant, we piloted the Growth Teams model in Rwanda, helping the government jumpstart the export-oriented call center (BPO) industry. Since 2022, that effort has contributed to the creation of 2,000 formal jobs and the emergence of some of the country’s largest private employers. We’ve since expanded to Tanzania, Malawi, and the Indian states of Goa and Meghalaya. To refocus the global development discourse on broad-based economic growth, we co-organized the Growth Summit with the Center for Global Development and the Charter Cities Institute, and have published articles in leading outlets including Stanford Social Innovation Review, ProMarket, and the Global Prosperity Institute. Our work has attracted support from Open Philanthropy, Schmidt Futures, and Mulago Foundation, and our advisors now include economists Lant Pritchett, Stefan Dercon, and Kunal Sen. 39: Help Luca De Leo Get Started In AI Safety Research No update received, but Luca now runs the AI safety group at the University of Buenos Aires, Argentina. 40: Typist For Saharon Shelah This was another ACXG+ Grant, funded by an anonymous outside funder and not listed in the original announcement. Saharon is a prolific and influential Israeli mathematician, but many of his discoveries are hand-written in an unpublishable format. This grant funded a typist to help make his results suitable for publication. According to this page, they have made over fifty new papers and preprints available. Second Cohort: One Year Updates 41: Lead-Acid Battery Recycling In Nigeria The Nigeria field research was a major success. We spent most of September doing field research in multiple major cities in Nigeria, and got a good sense of the used lead-acid battery supply chain. This field research served as the foundation for expanding our project, and has been very impactful in shaping our ongoing research. We published our findings from Nigeria, which were shared with Nigerian government regulators and global NGOs working on lead poisoning. The grant also gave us the on-the-ground experience we needed to both fully understand and credibly engage with groups, both in Nigeria and globally, on the ULAB issue. In the meantime, beyond continued research, we’ve also launched a dashboard (trade.leadbatteries.org) for analyzing global lead trade data. Right now, we’re: Launching two studies (one RCT, one environmental analysis) in Nigeria in collaboration with local universities to develop a more rigorous understanding of lead pollution due to low-standard ULAB recycling in Nigeria Collaborating with a non-profit incubator to launch an NGO focused on demand-side solutions Beginning a partnership with a West African environmental regulator to scale cheap air monitoring technology to quickly identify and reduce lead pollution from low-standard smelting If any of this sounds interesting to you, please sign up for our Substack (leadbatteries.substack.com) or send us an email at hugosmith@uchicago.edu! 42: Compensation For Kidney Donors The End Kidney Deaths Act (H.R. 2687 / EKDA) is a groundbreaking ten-year pilot program designed to save lives and reduce healthcare costs. It provides a refundable tax credit of $10,000 per year for five years, a total of $50,000, to living kidney donors who donate to a stranger, helping those who’ve waited the longest on the transplant list. Between 2010 and 2021, 100,000 Americans died while qualified and waiting for a kidney. The EKDA aims to change that trajectory. Within ten years of its passage, up to 100,000 Americans could receive a life-saving living donor kidney which typically lasts twice as long as a deceased donor kidney. This would not only save lives but also save taxpayers up to $37 billion. The legislation has been reintroduced in the House, and we have a committed Republican Senate lead. Now, we need a Democratic Senator to co-lead and help move this bipartisan effort forward. Time is short, and we are racing to pass the bill this Congressional session. 36 organizations already support the EKDA. Join the movement and help end preventable kidney deaths. Visit EndKidneyDeaths.org to help us get to the finish line. Elaine and her org have been working extremely hard on this; you can read a Vox article on their campaign here. If you want to sign up for her email list and get updates any time there is a representative you can contact or meeting you can join in, go here. 43: Genetic Hack To Prevent Suffering In the estimate of multiple team members, the ACX grant was “worth it” - it likely had a counterfactual net positive impact, even though we had to pivot from our initial fast-track plans for developing the precision anti-suffering therapy. We identify three primary streams of value: a) reducing uncertainty in the emerging field through early exploratory research, helping with the identification of dead ends and promising R&D trajectories; b) a wide range of downstream effects (beyond the “raising awareness” cliché), including talent mobilization and rekindled interest in suffering abolitionism as a distinct cause area; and c) certain developments that cannot yet be publicly disclosed. In December 2024, Marcin Kowrygo (Acting CEO & volunteering contributor), David Pearce (Director of Bioethics), Aatu Koskensilta (President), and a few other team members decided to leave The Far Out Initiative. They look forward to collaborating and applying their experience to advance the suffering abolitionist lineage in the spirit of open science, public good, and thoughtfully decentralized governance. Feel free to reach out to us at suffab at protonmail dot com to discuss collaboration opportunities! I wrote a post profiling the Far Out Initiative here. Unfortunately there were some internal disagreements, and the people ACX Grants was closest to left the organization. I plan to continue to monitor whatever they do next. 44: Advocate For Pandemic Response Team At FDA This team prefers has asked me not to discuss their progress publicly, but you can probably guess what their lives are like right now, and your guess would be correct. 45: Anti-Mosquito Drones We developed a cheap sonar that is able to detect, track and classify the ultrasonic echoes of mosquito wings at more than three meters. I believe it’s a world first! We also have control algorithms that take the sonar data and output control commands that both ram into mosquitoes and avoid the walls of a simulated environment. Our current work is on integrating both components on a real drone, and we expect to be able to kill mosquitoes by June. We’ve also made an internal impact study (napkin-sized) that shows we’ll be more cost-effective than ITNs in urban to periurban environments. So, we’re super excited with what comes next and can’t wait to share the videos of our first interceptions! More information [in the video below] and on our website, https://tornyol.com 46: Tarbell Fellowship For AI Journalism No update received, but they have a public website. I can’t find the Voices program in particular, but the overall fellowship completed their first class of seven fellows and is working on their second. 47: Germicidal UV Lamp Study The research has successfully demonstrated the ability of off the shelf ozone scrubbers to mitigate the ozone production of far-UVC lamps, is now available as a preprint (https://chemrxiv.org/engage/chemrxiv/article-details/67e4cde76dde43c9084d88b7). The paper has been submitted for publication and is currently undergoing peer review. Any ideas you have for potential funders we can approach to help execute our six-year plan to accelerate far-UVC would be appreciated https://blueprintbiosecurity.org/introducing-project-air/ 48: Technological Solutions To Animal Welfare Challenges Directly because of Innovate Animal Ag's work, the first U.S. egg producer publicly announced in the New York Times their adoption of in-ovo sexing technology, eliminating the need to cull day-old male chicks. The initial in-ovo sexing machine began operating in the U.S. at the end of 2024, with the first eggs from these hens expected on shelves in mid-2025. External evaluations estimate our work accelerated U.S. adoption of this technology by over seven years, meaning that once fully implemented, more than 2 billion chicks will have been spared. In addition to continuing to support the rollout of in-ovo sexing in the US and globally, we're now exploring other technologies and paths to impact. Current promising projects include developing humane slaughter methods for fish and advocating for USDA approval of a poultry vaccine against bird flu. They add: If you ever meet folks that are interested animal welfare and are partial to more technocratic and practical solutions, please continue to pass them our way, or connect them directly to me. 49: Assurance Contract Website www.Spartacus.app is an ACX grantee that created a platform to help solve coordination and collective action problems. It enables the creation of campaigns that build critical mass through conditional commitments, which only activate when a sufficient number of people join, converting risk and uncertainty into a higher probability of successful outcomes. They are currently facilitating several projects that leverage conditional commitments, including a dominant assurance contract interface for fashion pop-ups, accelerating a community business association's membership drive, and helping an AI safety organization organize petitions and events, among others. They have pivoted from an emphasis on high-stakes coordination problems requiring anonymity (because they occur too infrequently) to a broader range of more common use cases and have successfully run small-scale campaigns, but are still working toward product-market fit. Despite resource constraints and split time commitments that have impeded faster progress, they remain dedicated to the project's growth and success. You can follow its progress on X or Substack, or email Jordan directly here. 50: Cause Prioritization @ Center For Exploratory Altruism Research Moderately good progress on a salt reduction policy advocacy project we funded; informal commitments have been made by the Ministry of Health, and we're awaiting the publication of a formal administrative order. The official description sounds maximally generic, but this is an EA charity with a broad mandate whose current thesis is that dietary guidelines in developing countries can have outsized effects in saving lives. They’re making some progress on a salt reduction campaign in a developing country they prefer not to name publicly. 51: Mark Webb Studying Land Reform The purpose of this project was to identify specific farmland that could be acquired and transferred to the farmers already working the land. This has been difficult to achieve. I have been able to connect with other charities and landless farmers, and was able to interview a number of people about what their situation looks like, as well as what it would look like to them personally if they owned, rather than rented, their farmland. All this was immensely helpful in pushing this long-term project forward, even if I was unable to identify a specific plot of land that could be used to try the experiment. I intend to continue this project. If you have any insights or connections, I am interested. 52: More AI Advocacy In Australia Good Ancestors is focused on AI safety policy in Australia. Middle powers might be a useful path to influence as the US and China focus on racing, rather than safety. The ACX grant helped us give testimony about AI safety to the Australian Senate alongside Google, Microsoft and Facebook (We were the only nonprofit to give oral evidence to the inquiry. We also engaged government on other AI-related issues, including cybersecurity, biosecurity, consumer law and automated decision making (https://www.goodancestors.org.au/ai-safety). We’re currently working to inform voters about where parties stand on AI safety for the election, ahead of engaging on a likely Australian AI Act in 2025 (https://www.australiansforaisafety.com.au/). This is the same Australian lobbying organization we founded in Year 1, after a change in name and leadership. I continue to be excited about AI safety in middle-tier countries for a few reasons. First, these countries have some power in international organizations to set international standards. Second, companies will usually comply with any not-excessively-burdensome regulation set by any country with a significant market. Third, AI safety is underfunded by the standard of government programs, so Australia setting up a national AI Safety Institute would significantly expand the field. It’s kind of crazy that ACX Grants tier levels of money can have significant effects at this scale, but GA continues to do a great job and we continue to be proud to support them. 53: Campus For African School Of Economics At Zanzibar Charter City The ACX grant helped launch the first research center at the African School of Economics-Zanzibar, which is a main anchor of the Fumba Town charter city project in Zanzibar. This research center is called the Africa Urban Lab (AUL), focused on rapid urbanization across Africa. The AUL launched its first Diploma program in Urban Development with 38 students in our first cohort (now graduated!), including mayors, and deputy mayor, a director of a national Ministry of urban development, and many others. We published our research framing papers for the AUL's research agenda. We raised funding to launch an Urban Expansion Program that's now selecting 15 African cities to support in implementing urban expansion planning on the urban periphery. We held two Public Talks by renowned cities scholars and practitioners. We received additional funding from Emergent Ventures and from the Templeton Foundation. And we've partnered with 8 universities across the region, and with one of these universities (Ardhi) we'll be working with them to update their urban planning and urban economics curriculum (amplifying AUL's impact beyond our own organization). A longer update from end of 2024 is here: https://www.aul.city/blog/reflecting-on-africa-urban-lab-s-inaugural-year-2024-highlights) 54: Online Training Program For Health Workers In Developing Countries To date, over 11,000 health workers in Nigeria have completed our course on basic, life-saving newborn care. ACX funding was catalytic for helping us secure government approvals and complete an evaluation of the impact of our training on health workers' clinical practices. The evaluation shows that birth attendants provide better birth care after taking the course. We fed the evaluation results into an updated model, which suggests the program is 24 times more cost-effective than direct cash transfers (a widely recognized benchmark for cost-effectiveness). The program is likely to become even more cost-effective as we scale up. https://healthlearn.org/blog/updated-impact-model 55: Smartphone Pupillometry To Diagnose Neurological Conditions We have continued to expand our work in the smartphone pupillometry space and the development of our application, PupilScreen (https://www.apertur.ai/). We have expanded our pilot/research program to include new sites across the United States (Missouri, New Jersey, Kentucky, USAC racing, PitFit driver performance training in Indiana) and the world (Nepal, Taiwan, South Africa). We continue to publish at the leading edge of the pupillometry literature as well looking at concussion (https://neuro.jmir.org/2024/1/e58398 and https://pubmed.ncbi.nlm.nih.gov/39682632/), cerebral vasospasm (https://pubmed.ncbi.nlm.nih.gov/39128501/), and stroke (https://pubmed.ncbi.nlm.nih.gov/39674431/ and https://pubmed.ncbi.nlm.nih.gov/39561861/). Currently, we are raising a $3 million seed round via a SAFE to fund the expansion of our work into the hands of healthcare workers and the general public. We will first focus on traumatic brain injury for clinical use and develop a neuro-monitoring wellness application utilizing our technology for the general public. They add: “We would welcome connections to anyone that you think might be interested in supporting our work further by investing in our $3M seed round of funding.” 56: Mike Saint-Antoine’s Biology Tutorial Videos Since getting the grant, I've continued to make Youtube tutorials as planned. One series that I'm especially proud of is about how to make a neural network in the Julia programming language completely from scratch, with no imports, up to the point of being able to solve MNIST (https://www.youtube.com/playlist?list=PLWVKUEZ25V97tNULapu07DhWv6_W4NfpE). Also, a college student in Pakistan came across my videos and invited me to give a virtual Zoom-lecture to her department, so I ended up teaching a 6-hour "Python-for-Biologists" workshop to more than a hundred college students in Pakistan over Zoom. So that was pretty awesome. Also, lately I've been teaching some in-person classes too, mostly at Fractal University in NYC, and I also recently organized a day-long, in-person Beginner Python class for people in my local area (Philly suburbs) who wanted to learn some basic programming. I'm having a lot of fun with this project, and am grateful to Scott and the grant funders for their generosity! 57: Conceptual Boundaries Workshop On AI Safety The workshop was completed successfully; you can read a writeup here. 58: Apart Research To Incubate AI Safety Scientists No update received, but they have a public website, and you can see their impact metrics here. They seem to be in urgent need of more funding. 59: Primer On How To Achieve Political Change No update received and I can’t find anything about this. 60: Research IVF Clinic Success Rates We've built a predictive model that estimates the odds of having a child at different IVF clinics across the country while controlling for factors like patient age and infertility differences that can falsely make some clinics look better than others. We found that an average patient can increase their odds of having a kid by 43% just by going to a top 10% clinic. Patients unlucky enough to go to a bottom 10% clinic will reduce their odds of having a kid by 40%. Next month, we're adding several more clinics, 2023 data, additional procedural controls, and donor/gestational carrier models, which should push our accuracy beyond state-of-the-art models in this space and better isolate clinic impact on patient outcomes. We've launched ivf.clinic, a website where patients can access personalized IVF reports and browse our clinic rankings (though we're still squashing some bugs). Currently, we're expanding our research to include comprehensive insurance coverage and pricing data across clinics nationwide. If anyone has insights on automating the collection of IVF clinic pricing information, I'd love to hear from you at scelarek@gmail.com. 61: Replicate Study On Brain Wave Synchronization For Speeding Learning We have acquired and configured the OpenBCI UltraCortex Mark IV 8-channel EEG headset and a clinical-grade Biosemi 32-channel EEG system. We’ve implemented the required components for the experimental pipeline (computing alpha from EEG, flashing bright white light, presenting stimulus images). We are currently putting them together into a single system that we’ll use to collect the data from several participants. We are aiming to gather data on several participants in late June / early July and complete the pilot of the replication in July 2025. If you’d like to be a participant in the study, [they might announce a link once they have it]. 62: Advocate Repeal Of Interstate Runaway Compact No update received and I can’t find anything about this. 63: Animal Welfare (Especially Fish) In Turkiye Future For Fish asks companies to sign up to FFF's fish welfare commitment, which requires producers to certify their facilities and enforce specific standards for stocking density and harvest. Luckyfish, İlknak, Divan (35 restaurants, 17 hotels) and NG Hotels (5 hotels) have signed and published FFF's fish welfare commitment with İlknak publishing the commitment on their website. Kılıç published its first sustainability report detailing fish welfare policies, including enforcing a maximum stocking density of 10 kg/m³ and confirmation of electrical stunning practices. Longer version with some caveats: https://manifund.org/projects/improving-fish-w From the longer document, these commitments involve things like reducing overcrowding, or stunning fish before killing them. Over 30 million fish were affected just from their single largest commitment, and they say 100 fish are helped per dollar spent. 64: More Georgism Advocacy Lars and Will used the 2021 grant to co-found ValueBase. Will remained with the company, and Lars left to do advocacy work at the Center For Land Economics. Here’s their summary of how things are going: [Our] organization transitioned leadership with Greg Miller, a former Program Analyst at the US Department of Housing and Urban Development, and Lars Doucet, author of Land is A Big Deal and Co-Founder of Valuebase, working full time and Joe Caissie stepping aside. This transition happened naturally as the next career transition for each respective person. Since then, progress has been made on pushing forward legislation. Maryland had two bills introduced to give Baltimore and counties the ability to enact split-rate taxes. One of the bills passed the state senate and would allow Baltimore to enact land value taxes within one mile of rail corridors–this contains 50% of Baltimore’s land value. However, the legislative session ended. We expect the bill to revive next session. The Center for Land Economics has been actively working to help efforts to get this bill passed the line. At the same time, we have uncovered systematic undervaluing of vacant land in assessments. We are writing a report on the assessment issues in Maryland with actionable steps to resolve them.

Inline links: Codebuff, website, Substack, survives, a public Substack, in Rwanda, Growth Summit, Stanford Social Innovation Review, ProMarket, Global Prosperity Institute, Saharon, this page, eadbatteries.substack.com, here, here, a post profiling the Far Out Initiative here, https://tornyol.com, a public website, https://chemrxiv.org/engage/chemrxiv/article-details/67e4cde76dde43c9084d88b7, https://blueprintbiosecurity.org/introducing-project-air/, our way, connect them directly to me, www.Spartacus.app, X, Substack, here, https://www.goodancestors.org.au/ai-safety, https://www.australiansforaisafety.com.au/, https://www.aul.city/blog/reflecting-on-africa-urban-lab-s-inaugural-year-2024-highlights, https://healthlearn.org/blog/updated-impact-model, https://www.youtube.com/playlist?list=PLWVKUEZ25V97tNULapu07DhWv6_W4NfpE, here, public website, here, in urgent need, https://manifund.org/projects/improving-fish-w

Minnesota and Virginia also have legislation to enable cities to implement land value taxes. We are monitoring these efforts. There are a few other cities we are operating in. We have helped another organization prepare for a meeting in Tennessee by doing impact analysis of land value taxes in the city. We have presented to city officials in the City of South Bend who have expressed support for land value taxes. Finally, we are in conversation with a State Senator in Colorado who is a champion of land value taxes. Meanwhile, we have soft launched and developed the OpenAVMKit, which uses a unified schema to do assessment accuracy reports and automated valuation methods for any property tax data given. Valuation of land is the key binding constraint to successful implementation of land value taxes. We plan to be the leaders in this space with strong benchmarking capabilities and a repo that can enable the open-source community to make the best automated valuation methods. Along with these efforts, we have expanded the movement. We have posted to the Progress and Poverty Substack growing the subscriber base to around 5,000 subscribers. We have spoken to over 25 local advocates interested in working on land value taxes in their local communities. Yet, there is a long way to go. We need to start earning income through technical assistance contracts as our grant funding expires. We need to continue pushing for a state to implement, and we need to be prepared to tell the success story for when they do. 65: EN’s Work On Bacteriophage Therapy Our project is aimed at pioneering phage therapy in Nigeria, where limited resources/infrastructure have historically held back research in this field. Starting from the ground up, we are establishing the foundational systems needed to support a robust phage research ecosystem. So far, we’ve isolated 34 bacteriophages targeting Pseudomonas aeruginosa, an essential step toward building a comprehensive phage bank. This began with collecting a wide range of clinical Pseudomonas isolates, which we are now characterizing alongside the phages through genome sequencing and phenotypic assays including studies on phage stability across pH, temperature, and salinity ranges. Our long-term goal is to develop a phage-based hydrogel for treating diabetic wounds. On the regulatory front, we have secured approval from the Attorney General to register our nonprofit organization, the Centre for Phage Biology and Therapeutics. Additionally, we’re expanding into vaccine development; following a research stay in Prof. Roderick's lab at the University of Waterloo, we have initiated the design of a phage-based universal Salmonella vaccine aimed at covering all major serotypes—an urgent need underscored by Africa’s reliance on external vaccine sources during the COVID-19 pandemic. I have signed an MTA agreement with Roderick to use his phage-based vaccine platform patents to enable us to design vaccines against any common disease affecting us. This is only the beginning, but we are proud to be laying the scientific and institutional groundwork for homegrown phage innovation in Africa. Emergent Ventures funded EN before we did and deserves a lot of credit here also. 66: Create An Artificial Kidney For an implantable artificial kidney, the first essential component is a hemofilter designed to emulate the glomerulus. Critical requirements for this hemofilter include high permeability (to maximize flow for a given area), selectivity (specifically, the retention of albumin), and robust blood compatibility (ensuring sustained function over time). Our initial strategy focused on using negative surface charge to reduce fouling. I began by testing polyelectrolyte (PE) coatings on 24nm pore membranes featuring a negative terminal charge, similar to the glomerular barrier. These initial static tests, assessing platelet adsorption in whole blood, yielded positive outcomes for some polyelectrolytes, indicating potentially desirable blood compatibility. However, static test setups are not truly representative of dynamic in-vitro conditions and don't provide data on key parameters like permeability, fouling progression, or changes in membrane selectivity. To address these limitations, I designed and built a blood filtration setup. This system sustains human whole blood in circulation for 20 minutes, allowing us to analyze all the aforementioned parameters, as well as platelet activation markers. This has resulted in a fairly high-throughput system for evaluating any surface coating. I'm pleased to report this setup has been accepted for presentation at this year's European Society for Artificial Organs (ESAIO) conference. I am also currently working on a full manuscript, as I believe this system offers a viable way to partially replace animal experiments in our early-stage research, requiring only 1.2ml of human blood per run. Working with a PhD student (hired to support both this research and work on membrane substrates), we have continued testing these PE coatings, alongside PEG coatings, on our membranes. Here, we're finding that optimization of the coating layer is crucial. With the current PE coatings, we observe a permeability drop of about an order of magnitude compared to the base membrane, making them unsuitable for an implantable device in their present form. This is likely due to the specific nature of the initial PE layer, which we can modify. We also suspect there may be ingress of PE into the pores, meaning we're not achieving just a surface coating (our goal), but rather a very thick coating, which would explain the flux loss. Optimizing the coating process to control penetration depth is now a primary focus of my ongoing work. I am currently aiming for a flux of 20ul/min (as this is cap introduced by the protein gel layer anyway) but for it to be at this 'steady state' permeability without drop in permeability. I am also imaging the membranes after contact with SEM to see if there is indeed any platelet adsorption etc. Tugrul has the dubious honor of maybe being "the only person to climb a 4000m peak with severe kidney failure". To raise money and awareness for his artificial kidney project, he is running Climb Against Time, where he will climb 41 mountains over 4000m (13000 ft) this summer. He is looking for donors and climbing partners. 67: Add Tardigrade Genes To Human Cells The goal of this one was to make hybrid cells that are more resilient for research and certain medical applications. They report: The grant was to synthesize vectors for the expression of humanized tardigrade proteins that can be targeted to different areas of the cell. All the vectors were designed, generated, and transposed into human cells. The proteins all localize successfully (e.g. they match the designed target), with one exception (we are still working on validating it). We've done some stress testing with the trangenic cells, but haven't reached firm conclusions yet. We've further generated some multigene designs but have not yet transposed them into cells, but should shortly. We're hoping to submit a manuscript on the first round later this year. 68: Teach Forecasting To EU Policy-Makers The original project didn't work out, but our grantee (who still prefers to remain anonymous) is now working with an EU think tank pursuing the same agenda, and has been teaching forecasting workshops to policy-makers for the past two months. 69: Platform For Single-Cell Imaging They ended up unable to accept this grant and returned the money. 70: Open Source Polygenic Predictor For EA/IQ They have an update here. They think they have a predictor that can explain 12% of variance in intelligence, and they’re working on validating it and creating an easy-to-use website. 71: Improve Flu Vaccines The grant mainly funded agent based modelling to demonstrate the benefit of pre-existing immunity to pandemic influenza if and when a future pandemic occurs (academic publication will result). The original proposal was to attempt to influence the WHO influenza strain selection process. After attending WHO meetings and a global influenza conference, I believe this is not feasible. Stakeholder feedback was the potential short term negative effect on vaccine hesitancy is believed to outweigh the less tangible future benefit. Given the conservative nature of decision makers, pandemic vaccines are likely to remain research only. There are still green shoots of research into pandemic preparedness/prevention that I am continuing to work on. I'm working under the "Australians for Pandemic Prevention" brand of Good Ancestors, another group that ACX funded in 2024. 72: Scenario Analysis For Developing World Agricultural Programs In addition to the research and analysis funded by the grant, I’ve learned to code with LLMs and have built an MVP of the project. The app is being considered for further development by staff at a large international organization. 73: Further C’s Political Career C’s political career is going well, but he continues to think it wouldn’t be strategic to give more information publicly at this time. Lessons Learned I'm most impressed with our lobbying/advocacy organizations. In particular, Good Ancestors has gotten the Australian government to sign onto an international AI safety declaration, partner with various x-risk-related organizations, and (possibly) extend charity tax deductions to some EA causes that previously didn't have it - I think this on its own goes a substantial way to paying back the cost of all ACX Grants. Coalition to Modify NOTA has a kidney donation bill in front of Congress that the (very illiquid) prediction markets give a 45% chance of passing; if it works, it could save thousands of lives. The Georgists are partly responsible for bills making land value taxes slightly easier to implement in a handful of states. Good Science Project seems to have significantly improved science. Are lobbying organizations a better bet than other types of nonprofit (within the constraints of ACX Grants)? I'm not sure. It could just be that lobbyists are (naturally) better at playing themselves up and sounding successful than (for example) scientists, or that politicians are good at people-pleasing and make people feel heard and encouraged in a way that might not change overall policy later. Also, I recently talked to some grantmakers who funded a lobbying organization that superficially seems excellent, but they expressed concern it was net negative (!) by taking away oxygen and spotlight from potentially more effective orgs. So I am encouraged but wary. Animal welfare organizations were another standout success. Again, I don't know how to think about this - while I think our grantees were exceptional, there's also an issue where the scale of animal welfare challenges is so great, and work on them so neglected, that lots of organizations can save a million chickens here, or a million fish there, without particularly making a splash. On the one hand, this is exactly what effective altruism should be doing - exploring grants that are very high in linear utility even if they don't feel satisfying. On the other, they're unsatisfying - and also hard to assess retroactively. How many chickens should a good animal welfare grant save? Any realistic number will both be overwhelmingly large in absolute terms and far too small in relative terms. I'm most ambivalent about our science grants. Many of them say they are successful and can point to published papers which explain the science they did. But it's hard to judge whether anything useful has changed based on the science getting done. I know it's important to fund basic research and not just last-mile technology startups, but it's hard for a mini-grants program like this one to evaluate these kinds of abstract interventions. One disappointing result was that grants to legibly-credentialled people operating in high-status ways usually did better than betting on small scrappy startups (whether companies or nonprofits). For example, Innovate Animal Ag was in many ways overdetermined as a grantee - former Yale grad and Google engineer founder, profiled in NYT, already funded by Open Philanthropy - and they in fact did amazing work. On the other hand, there were a lot of promising ACX community members with interesting ideas who were going to turn them into startups any day now, but who ended up kind of floundering (although this also describes Manifold, one of our standout successes). One thing I still don't understand is that Innovate Animal Ag seemed to genuinely need more funding despite being legibly great and high status - does this screen off a theoretical objection that they don't provide ACX Grants with as much counterfactual impact? Am I really just mad that it would be boring to give too many grants to obviously-good things that even moron could spot as promising? Someone (I think it might be Paul Graham) once said that they were always surprised how quickly destined-to-be-successful startup founders responded to emails - sometimes within a single-digit number of minutes regardless of time of day. I used to think of this as mysterious - some sort of psychological trait? Working with these grants has made me think of it as just a straightforward fact of life: some people operate an order of magnitude faster than others. The Manifold team created something like five different novel institutions in the amount of time it's taken some other grantees to figure out a business plan; I particularly remember one time when I needed something, sent out a request to talk about it with two or three different teams, and the Manifold team had fully created the thing and were pestering me to launch a trial version before some of the other people had even gotten back to me. I take no pleasure in reporting this - I sometimes take a week or two to answer emails, and all of the predictions about my personality that this implies would be correct - but it's increasingly something that I look for and respect. A lot of the most successful grants succeeded quickly, or at least were quick to get on a promising track. Since everything takes ten times longer than people expect, only someone who moves ten times faster than people expect can get things done in a reasonable amount of time. In almost every case where I thought to myself “this is a cool idea, but I don’t know how it’s going to really pay off, as opposed to reaching a cool intermediate accomplishment and then stagnating”, this was a correct criticism, and I should have taken it more seriously. But I can’t rule out that these were good in vague and hard-to-measure ways that I should take more seriously. This one is really self-serving, but in general when people were good communicators (or even bloggers) and wowed me with the writing-composition of their application, they turned out to be a good bet. And when people were hard to understand and annoying to communicate with, even if their ideas seemed good, they were less likely to pan out. Overall Thoughts The total cost of ACX Grants, both rounds, was about $3 million. Do these outcomes represent a successful use of that amount of money? Very naively, startups originating from ACX Grants have about $50 million in value1. If ACX Grants is equivalent to a pre-seed funder, and pre-seed funders usually get ~5%, then if we were VCs we would have a portfolio worth $2.5 million. About 1/5 of ACX Grants were attempting to be market-valued startups, so if we assume the charitable portion did about as well as the startup portion, then the charity portion is “worth” $10 million. There’s some reason to expect this is too high, since much of the startup value came from one successful outlier. But there’s another reason to expect this is too low, since we were aiming at charity rather than market cap, and any actual market cap that our grantees got was an unexpected side effect. I’m treating this as a sanity check rather than as a real number. It’s harder to produce Inside View estimates, because so many of the projects either produce vague deliverables (eg a white paper that might guide future action) or intermediate results only (eg getting a government to pass AI safety regulations is good, but can’t be considered an end result unless those regulations prevent the AI apocalypse). Because we tend towards incubating charities and funding research (rather than last-mile causes like buying bednets), achieved measurable deliverables are thin on the ground. But here are things that ACX grantees have already accomplished: Improved the living/slaughter conditions of 30 million fish.

Inline links: Progress and Poverty Substack, Climb Against Time, here, 1

Open Thread 402

October 06, 2025 · Original source

3: Speaking of grants: Open Philanthropy’s program to reduce catastrophic risks from biology asks me to advertise that they are both hiring grantmakers, and looking for potential grantees with ambitious project ideas. They’re especially interested in work on physical transmission suppression, metagenomic sequencing, PPE, medical countermeasures, biosecurity capacity-building, and projects at the intersection of AI and catastrophic biological risk. No prior bio experience needed. For would-be grantmakers, see their job description, applications due Oct 19. For would-be grantees, see their expression of interest form.

Inline links: Open Philanthropy, job description, expression of interest form

Open Thread 408

November 17, 2025 · Original source

2: Big EA funder Open Philanthropy is looking for more AI safety grantmakers to help direct $100 million to the best alignment research. Ideal candidates will have familiarity with the field, high technical literacy, and good judgment. Compensation is $125K - $285K++ depending on role/level/experience, remote work possible but SF Bay location preferred, US visa sponsorship possible, application deadline is November 24th. See here for more.

Inline links: See here for more

Open Thread 409

November 24, 2025 · Original source

3: Big EA funder Coefficient Giving (formerly Open Philanthropy) wants to distribute ~$10 million to projects related to “AI for forecasting” or “AI for sound reasoning”. If you have an idea in this area and want a grant, see here for more information, deadline January 30 although submissions before December 1 are encouraged.

Inline links: see here for more information

Links For December 2025

December 10, 2025 · Original source

48: Open Philanthropy has changed its name to Coefficient Giving. Maimonides says that it is especially praiseworthy to donate to charity anonymously; surely it also qualifies if you spend $5 billion building up a great reputation, then change your name so that nobody knows who you are anymore. They say their new name marks a new chapter where they transition from being associated with one billionaire couple (Facebook co-founder Dustin Moskovitz and Cari Tuna) to a broader effort to connect donors and opportunities, but rumor is they’re also tired of being confused with the OpenAI nonprofit.

Inline links: Open Philanthropy has changed its name to Coefficient Giving

Open Thread 428

April 06, 2026 · Original source

4: A message from Coefficient Giving (formerly Open Philanthropy):

Backlinks

• ACX Grants 1-3 Year Updates
• ACX Grants: Project Updates
• AI Safety
• Australian government
• Brands
• Coefficient Giving
• DALL-E
• Davidson On Takeoff Speeds
• Demis Hassabis
• Dylan Matthews
• Every Bay Area House Party
• In Continued Defense Of Effective Altruism
• Jaan Tallinn
• Links For December 2025
• Links For June
• Links For November 2023
• Links For November 2024
• Lives Of The Rationalist Saints
• Malawi
• 24
• Open Thread 270
• Open Thread 340
• Open Thread 368
• Open Thread 402
• Open Thread 408
• Open Thread 409
• Open Thread 428
• Organizations: A
• Organizations: C
• Organizations: O
• Paul Christiano
• People: D
• People: P
• Publications: E
• Tales Of Takeover In CCF-World