Astral Codex Ten

Michael Sklar

4 min read

Michael Sklar

Article

Michael Sklar is a recurring person in the Astral Codex Ten archive, appearing 3 times across 3 issues between December 28, 2021 and November 04, 2022. The archive places it in contexts such as “Michael Sklar, $100,000, to automate part of the FDA approval process”; “emails to Michael Sklar … bounced”; “Michael Sklar and Confirm Solutions have gotten further funding from FTX”. It most often appears alongside 1DaySooner, ACX Grants, African Swine Fever.

Metadata

  • Category: People
  • Mention count: 3
  • Issue count: 3
  • First seen: December 28, 2021
  • Last seen: November 04, 2022

Appears In

Source Context

Recovered passages from the original issue text. When the raw archive preserved outbound links inside the source passage, they are listed directly under the quote.

ACX Grants Results
December 28, 2021 · Original source
Michael Sklar, $100,000, to automate part of the FDA approval process. Statisticians spend a lot of time designing faster and more efficient studies, but drug companies who want to use one of these creative study designs need the FDA's permission. Right now that's hard because FDA statisticians need to analyze it manually which takes a long time. Sklar is a statistics postdoc at Stanford working on mathematical techniques to model study design. He would like to create programs that FDA statisticians can use to quickly understand how a study works and have an opinion on it. He's given talks to the FDA and they seem interested. If he can make the program and the FDA can adopt it, that might make drug companies feel more secure proposing novel trial designs and make the approval process faster and easier. Sklar is also seeking a programmer with experience in cloud computing; if interested, please email sklarm@stanford.edu to receive further details on the project and compensation. He also has room for more funding.
Inline links: sklarm@stanford.edu
Open Thread 244
October 02, 2022 · Original source
1: I’m trying to collect information on how last year’s ACX Grants winners are doing. I should have emailed everyone involved a form, but I know that the emails to Michael Sklar and 1DaySooner bounced, and based on how few responses I’ve gotten I worry some others have as well. If this is you, please fill in this form by October 15. If you didn’t get an ACX Grant last year, no need to worry about this.
Inline links: this form
ACX Grants: Project Updates
November 04, 2022 · Original source
3: Software To Validate New FDA Drug Trial Designs (10/10) Michael Sklar and Confirm Solutions have gotten further funding from FTX and now have 2-3 people working full-time on the project. They are building new statistical techniques and software to help regulators quickly assess designs for clinical trials. Here is a recent conference poster on the methods. They have written proof-of-concept code and are writing a white paper to show regulators and pharma companies. They also claim to have developed software that has "sped up their simulations for some standard Bayesian trial designs by a factor of about 1 million." They are looking for more employees and collaborators; if you’re interested, contact research@confirmsol.org
Inline links: conference poster, proof-of-concept code, white paper
Michael Sklar’s project to speed up drug trial design is looking for more employees interested in drug trial design and statistics - contact research@confirmsol.org for more information.