Astral Codex Ten

1DaySooner

11 min read

1DaySooner

Article

1DaySooner is a recurring organization in the Astral Codex Ten archive, appearing 10 times across 10 issues between September 02, 2021 and June 18, 2025. The archive places it in contexts such as ""1DaySooner: FAQ: Long-Term Effects of COVID-19""; “1DaySooner and Rethink Priorities , $17,500, to research public attitudes around human challenge trials”; “emails to … 1DaySooner bounced”. It most often appears alongside ACX, ACX Grants, Australia.

Metadata

  • Category: Organizations
  • Mention count: 10
  • Issue count: 10
  • First seen: September 02, 2021
  • Last seen: June 18, 2025

Appears In

Source Context

Recovered passages from the original issue text. When the raw archive preserved outbound links inside the source passage, they are listed directly under the quote.

Long COVID: Much More Than You Wanted To Know
September 02, 2021 · Original source
1DaySooner: FAQ: Long-Term Effects of COVID-19
Inline links: FAQ: Long-Term Effects of COVID-19
ACX Grants Results
December 28, 2021 · Original source
1DaySooner and Rethink Priorities, $17,500, to research public attitudes around human challenge trials. Human challenge trials are studies where scientists deliberately try to infect volunteers with a disease to see if a treatment can prevent or cure it. They're much faster than waiting for people to get the disease naturally, and could have significantly shortened the wait for coronavirus vaccines. But they're controversial and nobody was able to get approval to do a challenge trial for COVID until 2021, which is why we had to wait so long for good treatment. Preliminary research suggests lots of people support these trials; I think building common knowledge of this is a first step towards making them available during future pandemics. Rethink Priorities is a respected effective altruist research organization. 1Day Sooner is a group lobbying for challenge trials. They’re currently seeking $10 million to use challenge studies to develop a universal coronavirus vaccine. Email josh@1daysooner.org if you can help
Inline links: 1DaySooner, Rethink Priorities, josh@1daysooner.org
Open Thread 244
October 02, 2022 · Original source
1: I’m trying to collect information on how last year’s ACX Grants winners are doing. I should have emailed everyone involved a form, but I know that the emails to Michael Sklar and 1DaySooner bounced, and based on how few responses I’ve gotten I worry some others have as well. If this is you, please fill in this form by October 15. If you didn’t get an ACX Grant last year, no need to worry about this.
Inline links: this form
ACX Grants: Project Updates
November 04, 2022 · Original source
14: Survey To Understand Public Attitudes Around Human Challenge Trials (5/10) 1DaySooner has developed their battery of questions and analysis pipeline. They just received IRB approval to conduct the full survey.
Open Thread 277
May 22, 2023 · Original source
1: ACX Grants update: 1DaySooner is surveying people who have been involved in conducting phase III clinical trials (eg doctor, nurse, statistician, recruitment coordinator) to get their opinion on human challenge trials. If you're in this category and willing to help, go to hctexpertopinion.com
Inline links: hctexpertopinion.com
My Left Kidney
October 27, 2023 · Original source
Josh Morrison of WaitlistZero (now of 1DaySooner), who encouraged me and gave me good advice.
Inline links: WaitlistZero
ACX Grants Results 2024
February 10, 2024 · Original source
1DaySooner, $100,000, to advocate for a specialized pandemic response team at the FDA. Although I complain about how long it took the FDA to approve the COVID vaccine, everything is relative, and they were able to approve it much faster than their usual process. This exhausted employees and created a backlog of other non-COVID tasks, and might not be possible even for another pandemic, let alone normal operations. 1DaySooner wants the government to fund an effort to make the FDA capable of Operation Warp Speed-style efforts in more situations, and maybe apply its lessons to everyday decisions. You can read more about their work here and here, and donate here.
Inline links: here, here, here
Open Thread 333
June 10, 2024 · Original source
1: A message from ACX Grantee 1DaySooner: California is considering a law to ban things that emit ozone. As unintentional collateral damage, this bill would ban far-UV light, a new disinfection technology that can potentially eliminate all indoor respiratory diseases, but which also creates trivial amounts of ozone. Far UV is almost ready for deployment, and could potentially save tens of thousands of lives yearly. 1DaySooner, a health-related charity, is trying to convince the California government to exempt it from this law, or at least to remember that it exists when writing the exact text of the bill. They are asking Californians to write to their representative about this. Representative Buffy Wicks is on a relevant committee, and support from her constituents (Berkeley, Richmond, and north Oakland) would be especially helpful. I’ve posted more information - including what you can say to your representative - as a comment below.
Inline links: 1DaySooner:, far-UV light, trying, Buffy Wicks, as a
1DaySooner's Trump II Health Policy Proposals
February 07, 2025 · Original source
1DaySooner is an ACX grantee organization that advocates for innovative health policies. They’ve helped me write a list of who some of these people are, and some of the policies they could consider.
Inline links: 1DaySooner
Compensating Organ Donors / End Kidney Deaths Act: Both of us co-writing this piece (Scott Alexander of ACX, Josh Morrison of 1DaySooner) have donated kidneys. We’re proud of our decision, but it’s not enough - waiting for people like us has resulted in a kidney shortage that kills a thousand Americans per month. Everyone knows the solution - compensating organ donors - but there hasn’t been enough political will to overcome the “ick” factor and make it happen. O’Neill could change that. He’s been speaking out in favor of compensation since 2009. And the time is right: Representative Nicole Malliotakis has introduced a bipartisan bill to provide $50,000 in refundable tax credits for people who donate kidneys to strangers. This paper found that a similar policy could eventually net 11,500 extra donors per year - which, aside from saving 11,500 people from end-stage kidney disease, could save the government $1 billion. O’Neill could boost this bill by getting it into the Executive Budget released with the State of the Union.
Inline links: donated, kidney shortage, been speaking out in favor of compensation since 2009, Representative Nicole Malliotakis, This paper, save, $1 billion
Regulatory Reciprocity: I will keep this one in here until somebody does something about it. It’s the idea that Americans should be allowed to buy medical products if they’ve been approved by some trusted ally, like the European Union, possibly in exchange for the EU giving FDA-approved products the same deal in Europe. This has been amply championed by Alex Tabarrok and the Mercatus crowd for years, and is starting to make inroads in other countries. If full reciprocity is a step too far, 1DaySooner proposes Makary build off innovative pilot programs like Project Orbis, which enables concurrent submissions and reviews of oncology drugs by multiple regulatory agencies, and the CoGenT pilot, which does the same for cell and gene therapies.
Inline links: Alex Tabarrok, Mercatus, starting to make inroads
ACX Grants 1-3 Year Updates
June 18, 2025 · Original source
This is great and the paper is great, but is also a microcosm of what I find frustrating about grantmaking. Will this paper change anyone’s mind? Will it lead to human challenge trials being more likely to happen? I assume yes, because 1DaySooner have proven to be generally smart people who know what they’re doing, but it’s hard to measure effects even now when we know exactly what the end product was.