Astral Codex Ten

clinicaltrials.gov

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clinicaltrials.gov

Article

clinicaltrials.gov is a recurring publication in the Astral Codex Ten archive, appearing 3 times across 3 issues between November 23, 2021 and August 14, 2025. The archive places it in contexts such as “A quick look at clinicaltrials.gov shows 11 studies”; “https://clinicaltrials.gov/ct2/show/NCT04809129”; “ClinicalTrials.gov, “A Donanemab (LY3002813) Study”. It most often appears alongside Scott, Dan Elton, Google.

Metadata

  • Category: Publications
  • Mention count: 3
  • Issue count: 3
  • First seen: November 23, 2021
  • Last seen: August 14, 2025

Appears In

Source Context

Recovered passages from the original issue text. When the raw archive preserved outbound links inside the source passage, they are listed directly under the quote.

Highlights From The Comments On The FDA And Paxlovid
November 23, 2021 · Original source
A quick look at clinicaltrials.gov shows 11 studies, 7 still in progress, concerning PF-07321332/ritonavir [ie Paxlovid]. Some are designed to look specifically at plausible bad interactions with common drugs. It's nice if the efficacy trial with ~1000 patients doesn't show any random safety problems, but it would be malpractice to not complete the safety tests on plausible bad drug interactions before unleashing it into a population that's going to be using it together with 100's of other drugs. Would you approve a drug without even a small test on people with hepatic impairment?
Inline links: clinicaltrials.gov
ACX Grants ++: The Second Half
February 10, 2022 · Original source
#67: Investigate Weighted Belts As An Appetite Suppressant I’m a data scientist with experience in healthcare and human subject research. I’m interested in the efficacy of weighted belts as an appetite suppressant. Over the last several years there's been interesting research on the gravitostat, a body weight homeostat independent of leptin that is controlled by the amount of weight loaded on the large bones. Two years ago, results from a “proof of concept” RCT were published showing that wearing weighted vests seems to reduce body weight and fat in humans. More research is needed, and more is being done (https://clinicaltrials.gov/ct2/show/NCT04809129), but none has focused on long term compliance or long term weight loss in humans wearing weighted clothes. I’m planning on sending subjects weighted clothing (various belts and vests), a randomized amount of weight, and instructions and guidance covering the theory etc. Compliance and body weight will be tracked and reported for two years along with surveys of what subjects' experiences have been. Resulting data and findings will be published. Improving compliance and intervention effectiveness through improved weighted clothing is something that academic researchers may be slow to focus on but could be of incredible value. Costs of the weighted clothing are estimated to be at least $5000. To provide funding or suggestions, contact me at justintgardiner@gmail.com.
In Defense Of The Amyloid Hypothesis
August 14, 2025 · Original source
[73] ClinicalTrials.gov, “A Donanemab (LY3002813) Study in Participants With Preclinical Alzheimer’s Disease (TRAILBLAZER‑ALZ 3).” ClinicalTrials.gov, NCT05026866, May 23, 2025. Accessed: Jul. 24, 2025. [Online]. Available: https://clinicaltrials.gov/study/NCT05026866
Inline links: https://clinicaltrials.gov/study/NCT05026866
[114] ClinicalTrials.gov, “DIAN‑TU Amyloid Removal Trial (ART): A Phase IIIb/IV Open‑Label Study of Lecanemab in Dominantly Inherited Alzheimer’s Disease.” ClinicalTrials.gov, NCT06384573, Jun. 10, 2024. Accessed: Jul. 24, 2025. [Online]. Available: https://clinicaltrials.gov/study/NCT06384573
Inline links: https://clinicaltrials.gov/study/NCT06384573
[115] ClinicalTrials.gov, “AHEAD 3–45 Study: A Phase 3 Placebo‑Controlled, Double‑Blind, Parallel‑Arm, 216‑Week Trial (with Extension) Evaluating BAN2401 (Lecanemab) in Preclinical/Early Preclinical Alzheimer’s Disease (A45 & A3 Trials).” ClinicalTrials.gov, NCT04468659, Jul. 14, 2020. Accessed: Jul. 24, 2025. [Online]. Available: https://clinicaltrials.gov/study/NCT04468659
Inline links: https://clinicaltrials.gov/study/NCT04468659