Organizations: Z

Groups, collectives, magazines, venues, and institutions operating inside the scene. This section collects the Z slice of the category index.

Reference Index

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Zillow

Zillow is a recurring organization in the Astral Codex Ten archive, appearing 4 times across 4 issues between March 05, 2021 and June 23, 2022. The archive places it in contexts such as "I went looking for a four-bedroom house in the America's various Springfields on Zillow"; "You can run a quick spot check by going on Zillow or Redfin in a major city"; "nothing would legally stop someone from scraping listing prices on Zillow". It most often appears alongside San Francisco, United States, Albouy.

Article page
Zillow
Mention count
4
Issue count
4
First seen
March 05, 2021
Last seen
June 23, 2022
March 05, 2021 · Original source
Just for kicks, I went looking for a four-bedroom house in the America's various Springfields on Zillow. You can get this one in Springfield, OH for $140K. Four bedrooms, two bathrooms, 2000 sqft, two-car garage, and it even looks a bit like the Simpson house. No trouble affording this for middle proles like the Simpsons.
December 09, 2021 · Original source
In 2020, all real estate in NYC was worth about $2.7 trillion, according to LendingTree (the land + the buildings). But let's go ahead and see for ourselves. You can run a quick spot check by going on Zillow or Redfin in a major city like New York or San Francisco. First, search for a vacant lot for sale in the heart of downtown, and note the asking price. Then look for a similarly-sized lot with a building on it that has sold within the last few years, situated next to the empty lot. The last selling price should be available. You can subtract one price from the other to get a rough estimate of the land share of the plot with the building on it.
December 11, 2021 · Original source
See if you can improve on the state of the art. How close to ground truth can you get? Once the first study is done, you'd want to test it in another area–maybe Australia, Denmark, Germany, or the Philippines. If Georgism is true, and the only thing standing in the way is being able to pull off accurate assessments, then let's just get better at doing that. We're the species that split the atom and travelled to the moon. Surely we can handle this. 6.2. Total Land Value of the United States It's really annoying that we don't confidently know this figure, and it has huge implications for LVT policy. Technically, this is an "assessment" problem, but in practice, when you're assessing the entire USA, you're often falling back on big black-box buckets of aggregated property values rather than building a database of direct ground-truth market transactions yourself. In Part I, we saw how big the difference was between Albouy, who used pure land sales directly from the market, and Larson, who applied the cost approach to official figures. If one of you readers has MLS access for all 50 states and/or a bunch of other records, it'd be interesting to see if we could settle this debate once and for all. 6.3. A Push for More Open Real Estate Market Transaction Data To my knowledge, there's no good, one-stop shop for solid, historical, ground truth real estate market transaction data that's uniform and detailed across, say, the entire United States. I'm well aware of how important access to solid data is for researchers. I run a site called www.gamedatacrunch.com that just quietly scrapes public metrics from the PC video game store Steam (they don't mind–I asked). I'm constantly getting requests from researchers to dump slices from my DB for them, which I'm always happy to do. If not for making this data available, those research papers might not be happening. So many questions that are answerable in principle go unanswered in practice simply for want of access to data, and then smart people make bad policy decisions because of that ignorance. In principle, I suppose nothing would legally stop someone from scraping listing prices on Zillow and Redfin all day, every day, but I have a feeling I'd probably get sued if I did that. (Just checked with my lawyer; he says it's a legal grey area but probably wouldn't end well for me.) If you're an eccentric billionaire who wants to do something for Georgism, instead of building a $400 billion super city in the desert, you could buy Redfin for about 1% of that and make their data available to researchers. In any case, whether improved access to consistent, country-wide data were to come from data mining or repeal of real estate non-disclosure laws, it would be an invaluable resource for researchers. 6.4. Empirical examination of ATCOR If ATCOR (All Taxes Come Out of Rent) holds up empirically, it would be a super big deal. Then, it wouldn't matter whose land value estimates you accept, because you'd always be able to shift taxes off of income and capital and onto land without losing revenue. Mason Gaffney cites a few cases where it's supposed to have been observed, but we could really dig into this further. A claim this tantalizing really needs to be nailed down and resolved once and for all. 6.5. Responses to Comments I've been absolutely drowning in comments since the first article posted and there's no way I'll be able to address everything. Doing full justice to some of these will require their own entire articles, but I can leave some brief notes here. Zoning Many people replied that Land Value Tax is useless until or unless you first fix zoning. First of all, Georgists are natural allies in fixing restrictive zoning policies. This is something they definitely want and will fight for. Second, one of the reasons for restrictive zoning policies is broken incentives. A city doesn't have a huge incentive to repeal restrictive zoning policies because it isn't hurting their tax base. According to Georgists, a city whose tax base is land value has well-aligned incentives. It is incentivized to maximize land value by making the city a more desirable place to live, which also raises their tax base. It is dis-incentivized to over-assess or over-tax the land, however, because that will cause people to leave, which will lower their land values and also their tax base. One of the principle things that depresses land values and the tax base in this scenario is restrictive zoning. I personally don't care whether you first pass LVT or first repeal restrictive zoning, you can and should do both. Either one helps the other along. Transitional Politics Honestly this needs its own entire article without me going out on a limb and accidentally saying something dumb. Suffice it to say, a lot of smart people have spent a lot of time thinking about this, and you'll have to wait for a future article to find out what they are. I will let the commentariat duke this one out in the meantime. Corruption Some people agreed to all of the points raised in theory, but pointed out that human beings are wicked sinners, and LVT will be bent towards the malevolent will of our overlords, just like the old policies. And they're not wrong! The problem with this argument is that it's a fully general argument against change. The overlords game every system to their benefit. Rely on standardized tests? They'll game the SAT's with phony disability accommodations and outright cheating. Abolish standardized tests? They'll make their kids take fifty extracurriculars and pay a ghost writer to pen their college entrance essay about their life-changing volunteer work in Ghana. The right question is not "can the rich game this system?" but rather, "can they game it less than the existing one?" This is why you should keep standardized tests, even though rich people can and do game them. The evidence shows that on balance standardized tests are one of the few ways a minority student from a poor background even has a chance to move upwards. So let's dig in. The chief way you can game Land Value Tax is to cozy up to your local assessor and get them to say your land is garbage and it's not valuable. However, you have to do this kind of corruption in the open. Your land value assessment is public record, and highly visible on a map, and will stick out like a sore thumb unless the entire area has been corrupted too. I grant that motivated people could plausibly pull this off to various degrees. You might be able to get the assessor to lie about your land value, but what's the status quo we're comparing against? We don't even know how much cash money value is being socked away in Switzerland and the Caymans, let alone by whom. And even if we did, good luck figuring out how to lure that back to a taxable jurisdiction. Land at the very least can't run or hide. My dream is for us to commoditize open source mass appraisal systems and push for public real estate transaction records everywhere, so that organizations and educated members of the public can do their own land value audits at scale. And again, this is something that just needs to be subjected to empirics. We can sling theory back and forth at each other all day, but the proof is in the pudding. There are places that have done Land Value Tax in the past, and there are places that do it today. A good candidate for a future article is looking at case studies of where LVT has been tried and explicitly look for this problem. Finally, defeatism is corruption's best friend. If you believe everything I'm saying here, and your only obstacle is fear of corruption, and you accept that LVT's vulnerability to corruption is not any worse than the status quo's...then why not just get out there and fight for the world you want to see? Nothing good ever came without a struggle. Finally, we come to the most important comment of all. By George Some people said I did the whole "By George" schtick too much. I'm sorry you feel that way, but... by George, the people have spoken: 6.6. Future Direction This won't be my last article on Georgism, but I haven't yet decided whether to post them on my own blog, Fortress Of Doors, or some standalone site. Nor have I decided what topic should come next. In the comments, feel free to weigh in with which direction you'd like to see me go, as well as any issues you felt were unresolved to your satisfaction. Also, please point out any places where my math looks weird, I was just plain wrong, or where I have misunderstood or misstated the research I'm citing. Thanks very much to this readership and to our host, Scott, for graciously letting me share these findings with you. Acknowledgements: I would like to thank the following people and organizations without whom this series would not have been possible: My wonderful wife Emily, for everything
June 23, 2022 · Original source
I was suspicious of using a state-based analysis to talk about cities, so I repeated her work with the 50 biggest US cities, using two different sets of price data - one from Kiplinger, one from Zillow. I found the Zillow numbers a little more plausible; here they are: This was slightly lower, r^2 = 0.42, but still pretty good! I also don’t think my city homelessness data were perfect (people report homelessness data not by city but by “continuum of care area”, and it’s complicated to figure out what the overall population of each area is), so it wouldn’t surprise me if that’s responsible for most of the decay from Alyssa’s analysis to mine. Here you can see that San Francisco has a pretty high homelessness rate, but no worse than some other big cities like DC, Boston, and New York (Shellenberger, to his credit, mentions this in the book). So how come everyone talks about SF all the time? Alyssa gives two main reasons. First, SF homeless tend to concentrate in a few areas downtown; this is also where a lot of the tourists and businesspeople are, so the average tourist or businessperson in San Francisco sees a lot more homeless people than they would if they were evenly distributed throughout the city. And second, SF homeless are less likely to be sheltered than homeless people elsewhere; Shellenberger notes that “over 99% of New York’s homeless have access to shelter. In San Francisco, just 42% do” (see here for other cities). Source is here; I think “street homeless” means the same as “unsheltered” We’ll talk more in Part 4 about why this might be, but one common theory is climate: San Francisco has year-round above-freezing temperatures, so there’s less urgency to shelter everyone. Alyssa shows that the relationship between temperature and percent unsheltered is strong: That regression line looks suspicious, but I hear computers are never wrong. So one possible conclusion is that SF has around the amount of homelessness you would predict from its very high housing prices, and around the percent unsheltered you would predict from its balmy winter weather, and there’s nothing further to be explained. Shellenberger does not like this conclusion. San Francisco’s mild climate alone cannot explain why it has more homeless people than other cities. Miami, Phoenix, and Houston have year-round warm weather and far fewer homeless than San Francisco per capita. Per capita homelessness in San Francisco, Greater Miami, Greater Phoenix, and Greater Houston in 2020 was 9.3, 1.3, 1.6, and 0.8 per 1,000 residents, respectively. And Greater Miami, Greater Phoenix, and Greater Houston saw their per capita homeless population decline from 2005 to 2020 by 39, 17, and 74 percent while San Francisco saw its rise 30 percent. Nor can housing prices explain the discrepancy. Palo Alto and Beverly Hills have mild climates and expensive housing but don’t have San Francisco’s homeless problem. As for the Zillow study that was reported to find a correlation between rising rents and homelessness, a deeper look at the research reveals a more nuanced finding. Homelessness and affordability are correlated only in the context of certain “local policy efforts [and] social attitudes,” concluded researchers. This feels like kind of a shell game. San Francisco’s mild climate alone can’t explain why it has more homeless people per capita than Miami or Houston. But as the graph above shows, housing prices do explain about 75% of the difference between SF and those two cities. But because the book talks about the Miami-SF discrepancy in the paragraph about climate instead of the paragraph about prices, it makes it sound like a mystery that neither prices nor climate can explain. The Zillow article mentioned is Homelessness Rises Faster Where Rents Exceed A Third Of Incomes, which is based on this study. Shellenberger’s summary is not really the researchers’ conclusion. The article does mention “local attitudes” and “social policy” once, but only to explain that the paper includes a term representing “latent factors” that they’re not going to bother distinguishing from each other in their model, and some of those terms could be local policy or social attitudes. Later they mention there are some outliers in their model (eg Houston), and it would be reasonable to assume that the latent factors help explain the outliers, but they don’t give us any reason to think that this is more interesting than the fact that every model ever will have outliers. But also, this is one study by Zillow. Alyssa and I both tried the same analysis, and found the same thing, with a correlation that’s unusually high for this kind of work. Sure, there are outliers, but San Francisco isn’t one of them. San Francisco is only a couple of percent off where the regression line would predict. That leaves the point about Palo Alto and Beverly Hills. They “have mild climates and expensive housing but don’t have San Francisco’s homeless problem”. At first I felt like this was cheating - yeah, rich suburbs don’t have lots of homelessness, come on. But “rich” and “high property values” are pretty close to synonyms. If you’re going to say that high property values cause homelessness, isn’t it in fact pretty surprising that rich suburbs don’t have it? In fact, if you’re a homeless person, why wouldn’t you want to live in a suburb? Quieter (so probably easier to sleep at night) more places out of sight to pitch tents, less crime (important if you’re living on the street!), and potentially lower cost of living in terms of food and goods. I tried looking into this issue and found explanations like: Usually it’s poor people who become homeless. Cities have more poor people than suburbs, because they have more rental units, small apartments, public transportation, and blue-collar jobs. Suburbs, by natural consequence of their layout, enforce a certain wealth minimum before people can live there, and people above that wealth minimum rarely lose everything and become homeless. It’s strange that poor people tend to live in cities (ie places with very high land values), and you have to wonder whether there are ways that could be different, but it does seem true.
That regression line looks suspicious, but I hear computers are never wrong. So one possible conclusion is that SF has around the amount of homelessness you would predict from its very high housing prices, and around the percent unsheltered you would predict from its balmy winter weather, and there’s nothing further to be explained. Shellenberger does not like this conclusion. San Francisco’s mild climate alone cannot explain why it has more homeless people than other cities. Miami, Phoenix, and Houston have year-round warm weather and far fewer homeless than San Francisco per capita. Per capita homelessness in San Francisco, Greater Miami, Greater Phoenix, and Greater Houston in 2020 was 9.3, 1.3, 1.6, and 0.8 per 1,000 residents, respectively. And Greater Miami, Greater Phoenix, and Greater Houston saw their per capita homeless population decline from 2005 to 2020 by 39, 17, and 74 percent while San Francisco saw its rise 30 percent. Nor can housing prices explain the discrepancy. Palo Alto and Beverly Hills have mild climates and expensive housing but don’t have San Francisco’s homeless problem. As for the Zillow study that was reported to find a correlation between rising rents and homelessness, a deeper look at the research reveals a more nuanced finding. Homelessness and affordability are correlated only in the context of certain “local policy efforts [and] social attitudes,” concluded researchers. This feels like kind of a shell game. San Francisco’s mild climate alone can’t explain why it has more homeless people per capita than Miami or Houston. But as the graph above shows, housing prices do explain about 75% of the difference between SF and those two cities. But because the book talks about the Miami-SF discrepancy in the paragraph about climate instead of the paragraph about prices, it makes it sound like a mystery that neither prices nor climate can explain. The Zillow article mentioned is Homelessness Rises Faster Where Rents Exceed A Third Of Incomes, which is based on this study. Shellenberger’s summary is not really the researchers’ conclusion. The article does mention “local attitudes” and “social policy” once, but only to explain that the paper includes a term representing “latent factors” that they’re not going to bother distinguishing from each other in their model, and some of those terms could be local policy or social attitudes. Later they mention there are some outliers in their model (eg Houston), and it would be reasonable to assume that the latent factors help explain the outliers, but they don’t give us any reason to think that this is more interesting than the fact that every model ever will have outliers. But also, this is one study by Zillow. Alyssa and I both tried the same analysis, and found the same thing, with a correlation that’s unusually high for this kind of work. Sure, there are outliers, but San Francisco isn’t one of them. San Francisco is only a couple of percent off where the regression line would predict. That leaves the point about Palo Alto and Beverly Hills. They “have mild climates and expensive housing but don’t have San Francisco’s homeless problem”. At first I felt like this was cheating - yeah, rich suburbs don’t have lots of homelessness, come on. But “rich” and “high property values” are pretty close to synonyms. If you’re going to say that high property values cause homelessness, isn’t it in fact pretty surprising that rich suburbs don’t have it? In fact, if you’re a homeless person, why wouldn’t you want to live in a suburb? Quieter (so probably easier to sleep at night) more places out of sight to pitch tents, less crime (important if you’re living on the street!), and potentially lower cost of living in terms of food and goods. I tried looking into this issue and found explanations like: Usually it’s poor people who become homeless. Cities have more poor people than suburbs, because they have more rental units, small apartments, public transportation, and blue-collar jobs. Suburbs, by natural consequence of their layout, enforce a certain wealth minimum before people can live there, and people above that wealth minimum rarely lose everything and become homeless. It’s strange that poor people tend to live in cities (ie places with very high land values), and you have to wonder whether there are ways that could be different, but it does seem true.
Zoom

Zoom is a recurring organization in the Astral Codex Ten archive, appearing 3 times across 3 issues between February 03, 2022 and August 25, 2025. The archive places it in contexts such as "Happy to chat over Zoom"; "I would also love to hold a Zoom call with anyone who finds this project interesting"; "gave a virtual Zoom-lecture to her department". It most often appears alongside ACX, ACX Grant, ACX Grants.

Article page
Zoom
Mention count
3
Issue count
3
First seen
February 03, 2022
Last seen
August 25, 2025
February 03, 2022 · Original source
#25: Scientific Research On Life History Models Of Mental Illness I'm J.D. Haltigan and I'm looking for funding to continue independent scientific research with my academic colleague investigating life-history models of psychopathology as they relate to the neurodevelopmental disorders of ASD, ADHD, and OCD. In order to optimally continue this work amidst the pandemic, funding that would allow us the potential of release from other academic duties (e.g., teaching, grant writing) would help advance this work which is pre-registered and described here: https://aspredicted.org/blind.php?x=2ea9vn. Currently I am seeking 5k USD and am happy to hold a Zoom call with anyone who who can provide funding or advice to provide further details on the project as well as my academic background and credentials. [You can reach me at jhaltiga@gmail.com]
#30: Retrofit Coronary Stents With Soft Edge Caps Coronary stent insertion is a common procedure (~600k/year in the U.S.) to treat coronary artery disease, but despite dramatic improvements in stent design, an estimated 3-20% of patients experience a major adverse cardiac event within 5 years of insertion. These post-implantation complications, such as in-stent restenosis and late stent thrombosis, are typically linked to inflammatory processes which arise from damage to the vascular wall during insertion. For example, recent studies show a 2x increased rate of major adverse cardiac events when stent edge dissection (a partial tissue lesion at the end of a stent) is detected. Alarmingly, new imaging techniques suggest that stent edge dissection may be present in ~40% of stent insertions. My name is Carl Thrasher and I am graduate student at MIT. I’m asking for $50k to prototype a method to retrofit existing stents with soft edge caps. I aim to 3D print these caps directly onto the stents using a bioresorbable polymer. This should help protect the vessel wall at the stent edge (the region of highest stress) without affecting long-term operation. I have experience in 3D printing and resin formulation. Future work would include testing in artificial vessels using optical coherence tomography. Even slight improvements here could be high impact saving millions of dollars and thousands of lives over a short time horizon. Happy to chat over Zoom or provide more detailed proposal information. Email: cthrash@mit.edu
#37: Study Antibiotic Resistance In Nigeria I am Nnaemeka Emmanuel Nnadi, a Medical Microbiologist in the Department of Microbiology, Plateau State University, Bokkos Nigeria. I am seeking for funding to help in understanding how the environment, poultry and humans interact in the spread of antimicrobial resistance in Plateau State. This study by extension will lead to the establishment of a laboratory that can be used to train undergraduates and postgraduate students in Molecular genomics. With a PhD in medical microbiology and a collaboration with Dr Luis Coelho an expert in computational biology our expertise matches this project. To actualize the goals of this project, we seek the sum of 50,000 USD. I would also love to hold a Zoom call with anyone who finds this project interesting. If you can provide funding or advice, please email eennadi@plasu.edu.ng or eennadi@gmail.com
June 18, 2025 · Original source
Codebuff, an AI coding startup I probably can’t take full credit for all of this just from giving them $20K in seed funding, but I continue to appreciate everything they do for this community and the world. 35: Further S’s Political Career This person didn’t win their election, but has since pivoted to AI safety and works in a well-regarded AI policy think tank. 36: Seeds Of Science, A Journal Of Non-Traditional Research No update received, but this was a public journal and it is easy to follow their work, see their website and Substack. They published two dozen articles of widely varying quality through 2023 and 2024, then closed in 2025. A remnant of the original vision survives as a science blogging aggregator. This was about my median expectation for this grant, but it was very inexpensive and I decided to take a chance on it anyway. 37: Good Science Project, Working To Improve Federal Science Funding No update received, but they have a public Substack discussing their progress. Their proposals for NIH reform have influenced Congress and made government agencies pay more attention to scientific integrity. 38: Advising Developing Countries On How To Grow Their Economies With our initial ACX grant, we piloted the Growth Teams model in Rwanda, helping the government jumpstart the export-oriented call center (BPO) industry. Since 2022, that effort has contributed to the creation of 2,000 formal jobs and the emergence of some of the country’s largest private employers. We’ve since expanded to Tanzania, Malawi, and the Indian states of Goa and Meghalaya. To refocus the global development discourse on broad-based economic growth, we co-organized the Growth Summit with the Center for Global Development and the Charter Cities Institute, and have published articles in leading outlets including Stanford Social Innovation Review, ProMarket, and the Global Prosperity Institute. Our work has attracted support from Open Philanthropy, Schmidt Futures, and Mulago Foundation, and our advisors now include economists Lant Pritchett, Stefan Dercon, and Kunal Sen. 39: Help Luca De Leo Get Started In AI Safety Research No update received, but Luca now runs the AI safety group at the University of Buenos Aires, Argentina. 40: Typist For Saharon Shelah This was another ACXG+ Grant, funded by an anonymous outside funder and not listed in the original announcement. Saharon is a prolific and influential Israeli mathematician, but many of his discoveries are hand-written in an unpublishable format. This grant funded a typist to help make his results suitable for publication. According to this page, they have made over fifty new papers and preprints available. Second Cohort: One Year Updates 41: Lead-Acid Battery Recycling In Nigeria The Nigeria field research was a major success. We spent most of September doing field research in multiple major cities in Nigeria, and got a good sense of the used lead-acid battery supply chain. This field research served as the foundation for expanding our project, and has been very impactful in shaping our ongoing research. We published our findings from Nigeria, which were shared with Nigerian government regulators and global NGOs working on lead poisoning. The grant also gave us the on-the-ground experience we needed to both fully understand and credibly engage with groups, both in Nigeria and globally, on the ULAB issue. In the meantime, beyond continued research, we’ve also launched a dashboard (trade.leadbatteries.org) for analyzing global lead trade data. Right now, we’re: Launching two studies (one RCT, one environmental analysis) in Nigeria in collaboration with local universities to develop a more rigorous understanding of lead pollution due to low-standard ULAB recycling in Nigeria Collaborating with a non-profit incubator to launch an NGO focused on demand-side solutions Beginning a partnership with a West African environmental regulator to scale cheap air monitoring technology to quickly identify and reduce lead pollution from low-standard smelting If any of this sounds interesting to you, please sign up for our Substack (leadbatteries.substack.com) or send us an email at hugosmith@uchicago.edu! 42: Compensation For Kidney Donors The End Kidney Deaths Act (H.R. 2687 / EKDA) is a groundbreaking ten-year pilot program designed to save lives and reduce healthcare costs. It provides a refundable tax credit of $10,000 per year for five years, a total of $50,000, to living kidney donors who donate to a stranger, helping those who’ve waited the longest on the transplant list. Between 2010 and 2021, 100,000 Americans died while qualified and waiting for a kidney. The EKDA aims to change that trajectory. Within ten years of its passage, up to 100,000 Americans could receive a life-saving living donor kidney which typically lasts twice as long as a deceased donor kidney. This would not only save lives but also save taxpayers up to $37 billion. The legislation has been reintroduced in the House, and we have a committed Republican Senate lead. Now, we need a Democratic Senator to co-lead and help move this bipartisan effort forward. Time is short, and we are racing to pass the bill this Congressional session. 36 organizations already support the EKDA. Join the movement and help end preventable kidney deaths. Visit EndKidneyDeaths.org to help us get to the finish line. Elaine and her org have been working extremely hard on this; you can read a Vox article on their campaign here. If you want to sign up for her email list and get updates any time there is a representative you can contact or meeting you can join in, go here. 43: Genetic Hack To Prevent Suffering In the estimate of multiple team members, the ACX grant was “worth it” - it likely had a counterfactual net positive impact, even though we had to pivot from our initial fast-track plans for developing the precision anti-suffering therapy. We identify three primary streams of value: a) reducing uncertainty in the emerging field through early exploratory research, helping with the identification of dead ends and promising R&D trajectories; b) a wide range of downstream effects (beyond the “raising awareness” cliché), including talent mobilization and rekindled interest in suffering abolitionism as a distinct cause area; and c) certain developments that cannot yet be publicly disclosed. In December 2024, Marcin Kowrygo (Acting CEO & volunteering contributor), David Pearce (Director of Bioethics), Aatu Koskensilta (President), and a few other team members decided to leave The Far Out Initiative. They look forward to collaborating and applying their experience to advance the suffering abolitionist lineage in the spirit of open science, public good, and thoughtfully decentralized governance. Feel free to reach out to us at suffab at protonmail dot com to discuss collaboration opportunities! I wrote a post profiling the Far Out Initiative here. Unfortunately there were some internal disagreements, and the people ACX Grants was closest to left the organization. I plan to continue to monitor whatever they do next. 44: Advocate For Pandemic Response Team At FDA This team prefers has asked me not to discuss their progress publicly, but you can probably guess what their lives are like right now, and your guess would be correct. 45: Anti-Mosquito Drones We developed a cheap sonar that is able to detect, track and classify the ultrasonic echoes of mosquito wings at more than three meters. I believe it’s a world first! We also have control algorithms that take the sonar data and output control commands that both ram into mosquitoes and avoid the walls of a simulated environment. Our current work is on integrating both components on a real drone, and we expect to be able to kill mosquitoes by June. We’ve also made an internal impact study (napkin-sized) that shows we’ll be more cost-effective than ITNs in urban to periurban environments. So, we’re super excited with what comes next and can’t wait to share the videos of our first interceptions! More information [in the video below] and on our website, https://tornyol.com 46: Tarbell Fellowship For AI Journalism No update received, but they have a public website. I can’t find the Voices program in particular, but the overall fellowship completed their first class of seven fellows and is working on their second. 47: Germicidal UV Lamp Study The research has successfully demonstrated the ability of off the shelf ozone scrubbers to mitigate the ozone production of far-UVC lamps, is now available as a preprint (https://chemrxiv.org/engage/chemrxiv/article-details/67e4cde76dde43c9084d88b7). The paper has been submitted for publication and is currently undergoing peer review. Any ideas you have for potential funders we can approach to help execute our six-year plan to accelerate far-UVC would be appreciated https://blueprintbiosecurity.org/introducing-project-air/ 48: Technological Solutions To Animal Welfare Challenges Directly because of Innovate Animal Ag's work, the first U.S. egg producer publicly announced in the New York Times their adoption of in-ovo sexing technology, eliminating the need to cull day-old male chicks. The initial in-ovo sexing machine began operating in the U.S. at the end of 2024, with the first eggs from these hens expected on shelves in mid-2025. External evaluations estimate our work accelerated U.S. adoption of this technology by over seven years, meaning that once fully implemented, more than 2 billion chicks will have been spared. In addition to continuing to support the rollout of in-ovo sexing in the US and globally, we're now exploring other technologies and paths to impact. Current promising projects include developing humane slaughter methods for fish and advocating for USDA approval of a poultry vaccine against bird flu. They add: If you ever meet folks that are interested animal welfare and are partial to more technocratic and practical solutions, please continue to pass them our way, or connect them directly to me. 49: Assurance Contract Website www.Spartacus.app is an ACX grantee that created a platform to help solve coordination and collective action problems. It enables the creation of campaigns that build critical mass through conditional commitments, which only activate when a sufficient number of people join, converting risk and uncertainty into a higher probability of successful outcomes. They are currently facilitating several projects that leverage conditional commitments, including a dominant assurance contract interface for fashion pop-ups, accelerating a community business association's membership drive, and helping an AI safety organization organize petitions and events, among others. They have pivoted from an emphasis on high-stakes coordination problems requiring anonymity (because they occur too infrequently) to a broader range of more common use cases and have successfully run small-scale campaigns, but are still working toward product-market fit. Despite resource constraints and split time commitments that have impeded faster progress, they remain dedicated to the project's growth and success. You can follow its progress on X or Substack, or email Jordan directly here. 50: Cause Prioritization @ Center For Exploratory Altruism Research Moderately good progress on a salt reduction policy advocacy project we funded; informal commitments have been made by the Ministry of Health, and we're awaiting the publication of a formal administrative order. The official description sounds maximally generic, but this is an EA charity with a broad mandate whose current thesis is that dietary guidelines in developing countries can have outsized effects in saving lives. They’re making some progress on a salt reduction campaign in a developing country they prefer not to name publicly. 51: Mark Webb Studying Land Reform The purpose of this project was to identify specific farmland that could be acquired and transferred to the farmers already working the land. This has been difficult to achieve. I have been able to connect with other charities and landless farmers, and was able to interview a number of people about what their situation looks like, as well as what it would look like to them personally if they owned, rather than rented, their farmland. All this was immensely helpful in pushing this long-term project forward, even if I was unable to identify a specific plot of land that could be used to try the experiment. I intend to continue this project. If you have any insights or connections, I am interested. 52: More AI Advocacy In Australia Good Ancestors is focused on AI safety policy in Australia. Middle powers might be a useful path to influence as the US and China focus on racing, rather than safety. The ACX grant helped us give testimony about AI safety to the Australian Senate alongside Google, Microsoft and Facebook (We were the only nonprofit to give oral evidence to the inquiry. We also engaged government on other AI-related issues, including cybersecurity, biosecurity, consumer law and automated decision making (https://www.goodancestors.org.au/ai-safety). We’re currently working to inform voters about where parties stand on AI safety for the election, ahead of engaging on a likely Australian AI Act in 2025 (https://www.australiansforaisafety.com.au/). This is the same Australian lobbying organization we founded in Year 1, after a change in name and leadership. I continue to be excited about AI safety in middle-tier countries for a few reasons. First, these countries have some power in international organizations to set international standards. Second, companies will usually comply with any not-excessively-burdensome regulation set by any country with a significant market. Third, AI safety is underfunded by the standard of government programs, so Australia setting up a national AI Safety Institute would significantly expand the field. It’s kind of crazy that ACX Grants tier levels of money can have significant effects at this scale, but GA continues to do a great job and we continue to be proud to support them. 53: Campus For African School Of Economics At Zanzibar Charter City The ACX grant helped launch the first research center at the African School of Economics-Zanzibar, which is a main anchor of the Fumba Town charter city project in Zanzibar. This research center is called the Africa Urban Lab (AUL), focused on rapid urbanization across Africa. The AUL launched its first Diploma program in Urban Development with 38 students in our first cohort (now graduated!), including mayors, and deputy mayor, a director of a national Ministry of urban development, and many others. We published our research framing papers for the AUL's research agenda. We raised funding to launch an Urban Expansion Program that's now selecting 15 African cities to support in implementing urban expansion planning on the urban periphery. We held two Public Talks by renowned cities scholars and practitioners. We received additional funding from Emergent Ventures and from the Templeton Foundation. And we've partnered with 8 universities across the region, and with one of these universities (Ardhi) we'll be working with them to update their urban planning and urban economics curriculum (amplifying AUL's impact beyond our own organization). A longer update from end of 2024 is here: https://www.aul.city/blog/reflecting-on-africa-urban-lab-s-inaugural-year-2024-highlights) 54: Online Training Program For Health Workers In Developing Countries To date, over 11,000 health workers in Nigeria have completed our course on basic, life-saving newborn care. ACX funding was catalytic for helping us secure government approvals and complete an evaluation of the impact of our training on health workers' clinical practices. The evaluation shows that birth attendants provide better birth care after taking the course. We fed the evaluation results into an updated model, which suggests the program is 24 times more cost-effective than direct cash transfers (a widely recognized benchmark for cost-effectiveness). The program is likely to become even more cost-effective as we scale up. https://healthlearn.org/blog/updated-impact-model 55: Smartphone Pupillometry To Diagnose Neurological Conditions We have continued to expand our work in the smartphone pupillometry space and the development of our application, PupilScreen (https://www.apertur.ai/). We have expanded our pilot/research program to include new sites across the United States (Missouri, New Jersey, Kentucky, USAC racing, PitFit driver performance training in Indiana) and the world (Nepal, Taiwan, South Africa). We continue to publish at the leading edge of the pupillometry literature as well looking at concussion (https://neuro.jmir.org/2024/1/e58398 and https://pubmed.ncbi.nlm.nih.gov/39682632/), cerebral vasospasm (https://pubmed.ncbi.nlm.nih.gov/39128501/), and stroke (https://pubmed.ncbi.nlm.nih.gov/39674431/ and https://pubmed.ncbi.nlm.nih.gov/39561861/). Currently, we are raising a $3 million seed round via a SAFE to fund the expansion of our work into the hands of healthcare workers and the general public. We will first focus on traumatic brain injury for clinical use and develop a neuro-monitoring wellness application utilizing our technology for the general public. They add: “We would welcome connections to anyone that you think might be interested in supporting our work further by investing in our $3M seed round of funding.” 56: Mike Saint-Antoine’s Biology Tutorial Videos Since getting the grant, I've continued to make Youtube tutorials as planned. One series that I'm especially proud of is about how to make a neural network in the Julia programming language completely from scratch, with no imports, up to the point of being able to solve MNIST (https://www.youtube.com/playlist?list=PLWVKUEZ25V97tNULapu07DhWv6_W4NfpE). Also, a college student in Pakistan came across my videos and invited me to give a virtual Zoom-lecture to her department, so I ended up teaching a 6-hour "Python-for-Biologists" workshop to more than a hundred college students in Pakistan over Zoom. So that was pretty awesome. Also, lately I've been teaching some in-person classes too, mostly at Fractal University in NYC, and I also recently organized a day-long, in-person Beginner Python class for people in my local area (Philly suburbs) who wanted to learn some basic programming. I'm having a lot of fun with this project, and am grateful to Scott and the grant funders for their generosity! 57: Conceptual Boundaries Workshop On AI Safety The workshop was completed successfully; you can read a writeup here. 58: Apart Research To Incubate AI Safety Scientists No update received, but they have a public website, and you can see their impact metrics here. They seem to be in urgent need of more funding. 59: Primer On How To Achieve Political Change No update received and I can’t find anything about this. 60: Research IVF Clinic Success Rates We've built a predictive model that estimates the odds of having a child at different IVF clinics across the country while controlling for factors like patient age and infertility differences that can falsely make some clinics look better than others. We found that an average patient can increase their odds of having a kid by 43% just by going to a top 10% clinic. Patients unlucky enough to go to a bottom 10% clinic will reduce their odds of having a kid by 40%. Next month, we're adding several more clinics, 2023 data, additional procedural controls, and donor/gestational carrier models, which should push our accuracy beyond state-of-the-art models in this space and better isolate clinic impact on patient outcomes. We've launched ivf.clinic, a website where patients can access personalized IVF reports and browse our clinic rankings (though we're still squashing some bugs). Currently, we're expanding our research to include comprehensive insurance coverage and pricing data across clinics nationwide. If anyone has insights on automating the collection of IVF clinic pricing information, I'd love to hear from you at scelarek@gmail.com. 61: Replicate Study On Brain Wave Synchronization For Speeding Learning We have acquired and configured the OpenBCI UltraCortex Mark IV 8-channel EEG headset and a clinical-grade Biosemi 32-channel EEG system. We’ve implemented the required components for the experimental pipeline (computing alpha from EEG, flashing bright white light, presenting stimulus images). We are currently putting them together into a single system that we’ll use to collect the data from several participants. We are aiming to gather data on several participants in late June / early July and complete the pilot of the replication in July 2025. If you’d like to be a participant in the study, [they might announce a link once they have it]. 62: Advocate Repeal Of Interstate Runaway Compact No update received and I can’t find anything about this. 63: Animal Welfare (Especially Fish) In Turkiye Future For Fish asks companies to sign up to FFF's fish welfare commitment, which requires producers to certify their facilities and enforce specific standards for stocking density and harvest. Luckyfish, İlknak, Divan (35 restaurants, 17 hotels) and NG Hotels (5 hotels) have signed and published FFF's fish welfare commitment with İlknak publishing the commitment on their website. Kılıç published its first sustainability report detailing fish welfare policies, including enforcing a maximum stocking density of 10 kg/m³ and confirmation of electrical stunning practices. Longer version with some caveats: https://manifund.org/projects/improving-fish-w From the longer document, these commitments involve things like reducing overcrowding, or stunning fish before killing them. Over 30 million fish were affected just from their single largest commitment, and they say 100 fish are helped per dollar spent. 64: More Georgism Advocacy Lars and Will used the 2021 grant to co-found ValueBase. Will remained with the company, and Lars left to do advocacy work at the Center For Land Economics. Here’s their summary of how things are going: [Our] organization transitioned leadership with Greg Miller, a former Program Analyst at the US Department of Housing and Urban Development, and Lars Doucet, author of Land is A Big Deal and Co-Founder of Valuebase, working full time and Joe Caissie stepping aside. This transition happened naturally as the next career transition for each respective person. Since then, progress has been made on pushing forward legislation. Maryland had two bills introduced to give Baltimore and counties the ability to enact split-rate taxes. One of the bills passed the state senate and would allow Baltimore to enact land value taxes within one mile of rail corridors–this contains 50% of Baltimore’s land value. However, the legislative session ended. We expect the bill to revive next session. The Center for Land Economics has been actively working to help efforts to get this bill passed the line. At the same time, we have uncovered systematic undervaluing of vacant land in assessments. We are writing a report on the assessment issues in Maryland with actionable steps to resolve them.
August 25, 2025 · Original source
There will be a Zoom Q&A with the authors, available to book pre-orderers only, on September 4.
Zip2

Zip2 is a recurring organization in the Astral Codex Ten archive, appearing 2 times across 2 issues between September 13, 2023 and September 18, 2023. The archive places it in contexts such as "employees [of Zip2, his first startup]"; "Musk asked those first employees of Zip2 to give him a kick when they arrived"; "Elon started his first startup, Zip2, together with his brother Kimball". It most often appears alongside Ashlee Vance, Boeing, Elon.

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Zip2
Mention count
2
Issue count
2
First seen
September 13, 2023
Last seen
September 18, 2023
September 13, 2023 · Original source
As a bonding exercise one weekend, Musk, Ambras, a few other employees [of Zip2, his first startup] and friends took off for a bike ride through the Saratoga Gap trail in the Santa Cruz Mountains. Most of the riders had been training and were accustomed to strenuous sessions and the summer’s heat. They set up the mountains at a furious pace. After an hour, Russ Rive, Musk’s cousin, reached the top and proceeded to vomit. Right behind him were the rest of the cyclists. Then, fifteen minutes later, Musk became visible to the group. His face had turned purple, and sweat poured out of him, and he made it to the top. “I always think back to that ride. He wasn’t close to being in the condition needed for it,” Ambras said. “Anyone else would have quit or walked up their bike. As I watched him climb that final hundred feet with suffering all over his face, I thought, That’s Elon. Do or die but don’t give up.”
Musk never seemed to leave the office. He slept, not unlike a dog, on a beanbag next to his desk. “Almost every day, I’d come in at seven thirty or eight a.m., and he’d be asleep right there on that bag,” Heilman said. “Maybe he showered on the weekends. I don’t know.” Musk asked those first employees of Zip2 to give him a kick when they arrived, and he’d wake up and get back to work.
September 18, 2023 · Original source
Elon started his first startup, Zip2, together with his brother Kimball. But I don’t get the impression Kimball was much of a moderating influence on Musk; if anything, they were too similar. Here’s what Vance had to say about their relationship:
Zacky Farms

Zacky Farms is a recurring organization in the Astral Codex Ten archive, appearing 1 times across 1 issues between May 24, 2022 and May 24, 2022. The archive places it in contexts such as "At Zacky Farms, the workers were viewed like family". It most often appears alongside #Abolitionist, #AntiNazi, #antiwar.

Reference entry
Zacky Farms
Mention count
1
Issue count
1
First seen
May 24, 2022
Last seen
May 24, 2022
May 24, 2022 · Original source
He tells the inspiring (?) story of how he grew up toiling in the chicken mines, “work[ing] alongside the workers, doing the dirty jobs, asking them questions on how to improve production and what the company could provide to motivate them. At Zacky Farms, the workers were viewed like family.”
Zaha Hadid

Zaha Hadid is a recurring organization in the Astral Codex Ten archive, appearing 1 times across 1 issues between April 14, 2021 and April 14, 2021. The archive places it in contexts such as "Principal Architect of Zaha Hadid, a world-famous architectural firm". It most often appears alongside Alaska, America, Amisulpride.

Reference entry
Zaha Hadid
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1
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1
First seen
April 14, 2021
Last seen
April 14, 2021
April 14, 2021 · Original source
Patrick Schumacher is the Principal Architect of Zaha Hadid, a world-famous architectural firm that designed eg Beijing International Airport and the London Olympics’ Aquatics Center. He’s won some of architecture’s most prestigious prizes, but also faced controversy over views his Wikipedia page describes as “aligned with anarcho-capitalism in favour of complete decentralisation and radical privatisation of all aspects of architecture, planning and development”. He recently lost a court case over ownership of his architecture company, and…wait, haven’t I read this Ayn Rand book before?
Trey: “Building codes and rules around aesthetics and setbacks and whatnot prohibited them from designing low cost, beautiful Zaha Hadid style structures prior to now. And without modular construction, it was impossible to get construction costs down to a reasonable number. But they’ve finally managed to pull it off, in coordination with [local startup] Circular Factory.” Drones sold separately. I think. Actually, scratch that, who even knows anymore? Próspera also promises an unprecedented level of customization. The houses are modular enough that you can design yours however you want. I haven’t been able to get access to the real program (called “the Configurator”) yet, but here are some apparent screenshots:
Zapatistas

Zapatistas is a recurring organization in the Astral Codex Ten archive, appearing 1 times across 1 issues between May 04, 2021 and May 04, 2021. The archive places it in contexts such as "more amorphous movements like the Zapatistas in Mexico". It most often appears alongside 2008, 9/11 attacks, A Brief History Of Neoliberalism.

Reference entry
Zapatistas
Mention count
1
Issue count
1
First seen
May 04, 2021
Last seen
May 04, 2021
May 04, 2021 · Original source
Wrong about China - but right about the US! Harvey goes on to predict that these may not happen within traditional political parties, but instead be more amorphous movements like the Zapatistas in Mexico. I’m not sure how to judge this - my guess is there’s a Revolt Of The Public argument that he’s right, and I’m too stuck in modernity to notice.
ZEDE

ZEDE is a recurring organization in the Astral Codex Ten archive, appearing 1 times across 1 issues between November 08, 2021 and November 08, 2021. The archive places it in contexts such as "the ZEDE’s version". It most often appears alongside America, Apolo Group, Ashkenazi.

Reference entry
ZEDE
Mention count
1
Issue count
1
First seen
November 08, 2021
Last seen
November 08, 2021
  • 21 November 08, 2021
November 08, 2021 · Original source
In May 2020, just after Próspera broke ground, its relationship with Crawfish Rock started to unravel. There were protests over the fact that few construction jobs went to villagers and an outcry after Próspera’s armed security guards, responding to a spate of robberies, began asking people coming and going from Crawfish Rock to identify themselves and state their business. On Próspera’s website, Cárdenas found sketches of its future footprint. Although hard to tell, it looked worryingly like the ZEDE planned to absorb Crawfish Rock, and some villagers worried that Próspera officials would ask the Honduran government to expropriate their land on the ZEDE’s behalf. At best, as Próspera grew, it would cut off Crawfish Rock from the rest of the island, pinning it against the sea.
The following month, Brimen flew to Roatán. Several civil society groups had issued a statement criticizing Próspera’s treatment of Crawfish Rock, and he wanted the patronato to disavow it on the village’s behalf. But before that could happen, villagers opposed to the ZEDE called for a new vote, one not orchestrated by Próspera. Though only in her 30s, Cárdenas, now a leader of Crawfish Rock’s opposition to Próspera, was elected vice-president, and her friend Luisa Connor became president.
In late October, Cárdenas and Connor received an unsigned letter from the Próspera Foundation, a new name for the charitable organization Monterroso oversees. The foundation had heard that the pair were looking at ways of restoring Crawfish Rock’s old water supply. The letter said that the foundation assumed that meant they no longer wanted to access water from the ZEDE’s well, and was going to cut them off in 30 days’ time.
Zeitgeist

Zeitgeist is a recurring organization in the Astral Codex Ten archive, appearing 1 times across 1 issues between October 18, 2022 and October 18, 2022. The archive places it in contexts such as "new ones I've heard about recently: Zeitgeist". It most often appears alongside 2024 elections, 5 U.S.C. §§ 558, 706, 538.

Reference entry
Zeitgeist
Mention count
1
Issue count
1
First seen
October 18, 2022
Last seen
October 18, 2022
  • 22 October 18, 2022
October 18, 2022 · Original source
6: Most new prediction markets are scams, doomed, or weird crypto cruft, and I promote them out of this category only after a long history of success - but for the record, here are the new ones I've heard about recently: Mojito, Zeitgeist, Seer
Zhou

Zhou is a recurring organization in the Astral Codex Ten archive, appearing 1 times across 1 issues between September 01, 2023 and September 01, 2023. The archive places it in contexts such as "The Zhou royal house lost control of its lords". It most often appears alongside 536 BC, ACX, Ai Jiang.

Reference entry
Zhou
Mention count
1
Issue count
1
First seen
September 01, 2023
Last seen
September 01, 2023
September 01, 2023 · Original source
But the Shang faced growing threat from the Zhou, a once-subordinate people from west beyond the mountains. Inspired by a rare conjunction of the planets in 1059 BC, the Zhou declared that there was such a thing as the Mandate of Heaven, a divine right to rule—and while the Shang had once held it, their misrule and immorality had forced the Mandate to pass to the Zhou. Thirteen years later, the Zhou and their allies defeated the Shang in battle, seized their capital, drove their king to suicide, and supplanted them as overlords of the Central Plains.
If the Shang were goth jocks, the Zhou were prep nerds. In grave goods, food-serving vessels replaced wine vessels. Mass human sacrifice disappeared, while bureaucracy expanded. The Shang lacked the state power to administer their surrounding subject peoples so much as intimidate them into line; the Zhou, galvanized by a rebellion not long after the conquest, put serious thought into consolidating their control. While the king remained in the west to rule over the original Zhou lands, he sent relatives and allies east into the conquered territories to establish colonies at strategically important locations, anchoring Zhou rule in a sprawling network of hereditary regional lords bound together by blood, marriage, custom, and ancestor worship of the Heaven-blessed founding Zhou kings.
For generations, the system worked, ensuring military successes at the borders and stability in the interior. The first reigns of the dynasty became a golden age in the cultural imagination for thousands of years. But by the dynasty’s second century, barbarian incursions were putting the state on the defensive, and surviving records hint at waning control over the regional lords and power struggles at court. 771 BC marked a breaking point, when barbarians allied with disgruntled nobles to overrun the royal domain and kill King You of Zhou.
Zizians

Zizians is a recurring organization in the Astral Codex Ten archive, appearing 1 times across 1 issues between February 27, 2025 and February 27, 2025. The archive places it in contexts such as "Police have finally arrested most of the Zizians, a murder cult with links to the rationalist social scene". It most often appears alongside /r/NootropicsDepot, @fae_dreams, @ObhishekSaha.

Reference entry
Zizians
Mention count
1
Issue count
1
First seen
February 27, 2025
Last seen
February 27, 2025
February 27, 2025 · Original source
39: Police have finally arrested most of the Zizians, a murder cult with links to the rationalist social scene (though they broke connections and turned against us before the murders started). Congrats to Evan Ratliff of WIRED, whose article (paywalled, but you can CTRL+A, CTRL+C, and paste to Notepad if you’re fast!) somehow gets the entire convoluted story entirely correct. Hall of shame goes to Vox, which mangles things in a way that tars innocent people - in particular, they confuse the Zizians with the postrationalists, a different group that started out part of the rationalist movement and later turned against us, but whose crimes are mostly limited to annoying Twitter posts.
Zymergen

Zymergen is a recurring organization in the Astral Codex Ten archive, appearing 1 times across 1 issues between February 27, 2025 and February 27, 2025. The archive places it in contexts such as "Three of the most promising synthetic biology companies - Gingko, Zymergen, and Amyris". It most often appears alongside /r/NootropicsDepot, @fae_dreams, @ObhishekSaha.

Reference entry
Zymergen
Mention count
1
Issue count
1
First seen
February 27, 2025
Last seen
February 27, 2025
February 27, 2025 · Original source
11: Intrinsic Perspective wants a law saying AI-generated text must be watermarked. I was most interested the article’s claim that there is now “semantic watermarking” - watermarking which operates on the level of ideas, and can’t be defeated by rephrasing an AI-generated text in your own words. I have skimmed the paper explaining this and think I vaguely understand what’s going on, but it still boggles me that this is possible. 12: Aella: How OnlyFans Took Over The World. There have been camgirl sites since forever. How did OnlyFans leap over all of its predecessors and achieve an unprecedented level of success? Aella discusses many factors, but one stands out: traditional camsites advertised the site as a whole, and then once you got to the site you chose which model you wanted to see. OnlyFans encourages models to advertise themselves - often on their own social media accounts, sometimes via scams - which “unlocks human creativity” on the problem of bringing new eyeballs to a porn site. 13: Nate Silver has 113 predictions for Trump’s second term. I’d be interested to see whether making each of these predictions 10% less confident (to account for possible gameboard-overturning AI) ends up beating Nate. 14: Sarah Constantin: What’s Behind The SynBio Bust? Three of the most promising synthetic biology companies - Gingko, Zymergen, and Amyris - all crashed between 2021 and 2023. Why? Producing chemicals in traditional factories is orders of magnitude more efficient than synthesizing them via microbes (except for the sort of large biomolecules that can’t be produced in factories). These companies had brilliant employees and cool tech, but no clear plan to get around this handicap, and used up their runway before they could figure one out. They also focused too hard on designing the microbes, and were too willing to outsource the actual manufacturing to other people without being sufficiently paranoid that those other people were doing quality control. 15: One of the more exciting psychiatric results (which I blogged about a long time ago) was the apparent finding that omega-3 supplementation could prevent high-risk people from having first break schizophrenia. A new RCT says this doesn’t replicate and cites two other recent trials showing it didn’t replicate. There’s also a new meta-analysis which says actually it does replicate, but usually failing a big RCT is a bad sign and I’m pretty skeptical. Thanks to Isaak F for the links. {ETA: Thomas Reilly says: “Although I don't believe omega-3 supplementation has any benefit in psychosis, I also don't think this new trial should shift your opinion much, given the total sample size was n=135 and the total number of transitions to psychosis was n=8.”] 16: Claim that predictions of global warming magnitude are gradually going down thanks to successful pledges/action: Source is CipherNews (h/t Stefan Schubert) apparently citing Climate Action Tracker, but I get the impression that this is just some people eyeballing the size of pledges and not any more sophisticated forecasting. I don’t know how to square this with the claims that such and such a thing (summer temperature, sea ice, etc) is much worse than anyone expected. 17: I don’t know anything about the Lucy Letby case, but all of my smart friends who have been right about this kind of thing before say she’s innocent. 18: A reader asks House of Strauss (edgy sports Substack) whether the vibe shift away from political correctness threatens the edgy Substack business model - as the power of orthodoxy declines, can you still get rich and famous as a brave anti-orthodoxy critic? His answer: nothing that can happen from here is as bad as the Twitter/X link deboost (which made attracting attention harder for everyone). I mostly agree: I think discoverability has suffered, people who are already famous will be able to stay famous without too much extra effort, and everyone else will have to explore new options. 19: Spectator: Could AI Lead To A Revival Of Decorative Beauty? Profiles Not Quite Past, a startup using AI and fancy printing to make customized Delft tiles. It’s a good idea and the tiles are very pretty, but the tiles are sort of a best possible case (a pretty, traditional object that can have a customized 2D image and be mass-printed). I think most forms of lost decorative beauty aren’t bottlenecked by ability to generate 2D images of the type image models are good at, and so will have to wait. 20: Some friends including Kelsey Piper wrote an emergency PEPFAR Report, collecting evidence for why PEPFAR is good/effective/important and deserves to be kept. Some key points: PEPFAR has saved between 7.5 and 30 million lives, at a cost between $1,500 and $10,000 per life saved. The US government is willing to spend at least a thousand times this much to save an American life.