Astral Codex Ten

Concepts: P

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Concepts: P

Ideas, aesthetics, movements, and abstractions named in the archive. This section collects the P slice of the category index.

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Progress Studies9 mentions across 9 issues

Progress Studies is a recurring concept in the Astral Codex Ten archive, appearing 9 times across 9 issues between May 10, 2021 and December 29, 2025. The archive places it in contexts such as "Where is the cultural-change equivalent of Progress Studies"; "Tyler Cowen, Patrick Collison, etc’s Progress Studies movement"; "Working within ... Progress Studies movement to '[establish] a new philosophy of progress for the twenty-first century'". It most often appears alongside 4chan, Tyler Cowen, AI.

Article page
Progress Studies
Mention count
9
Issue count
9
First seen
May 10, 2021
Last seen
December 29, 2025
Outbound links
Issue trail
Related pages
Source context
The Rise And Fall Of Online Culture Wars
May 10, 2021 · Original source
How did the counterculture eventually win, and the patriotic/Christian amalgam civil religion of the 1950s - 1990s eventually collapse? I don’t have a great understanding of this (though see Part III here), and I’d love to learn more so I can develop a real game plan. Where is the cultural-change equivalent of Progress Studies, and what might we be able to do if we had it?
Inline links: here
Links For September
September 20, 2021 · Original source
14: Congratulations to Jason Crawford, whose Roots Of Progress blog is now a nonprofit organization working within Tyler Cowen, Patrick Collison, etc’s Progress Studies movement to “[establish] a new philosophy of progress for the twenty-first century”. They are fundraising and also looking for a Chief of Staff.
Inline links: Roots Of Progress, a nonprofit organization, Chief of Staff
ACX Grants ++: The Second Half
February 10, 2022 · Original source
#78: Research Questions In Progress Studies With funding from ACX Grants I will investigate a set of specific and crucial open questions for Progress Studies: What is our capacity to slow technological progress if desired? What are general properties of technology which limit or exacerbate existential risk? How robust are recommendations to different sets of moral ethics? These are crucial to understanding the importance of accelerating progress, but relatively little effort has been devoted to these questions outside of AppliedDivinityStudies’ The Moral Foundation of Progress, and my own Stubborn Attachments From Behind The Veil. In the past, I’ve interned on economic policy at the CATO Institute and The Charter Cities Institute where I published on growth and governance. ADS has also agreed to mentor me over the summer, and provides a vote of confidence. If you’re able to provide funding, please email maxwell.tabarrok@gmail.com.
#111: Long-Termism + Progress Studies Unconference Long-termism + Progress UnConference. We intend to solve the problem of unproductive conferences and the challenges of the interdisciplinary nature of long-termism, existential risk and progress studies by applying participatory techniques (OpenSpace) in an UnConference format. We need collaborators more than money, but budget is c. $15K. What: An innovative conference format bringing cross-silo thinkers and doers together to think about the long-term and progress. Typical conferences work badly. Hierarchies and old networks impede new connections and growth in social and relationship capital. The best conversations occur in the corridors of typical conferences. Why: The long-term is vital for humanity. Ideas are multidisciplinary and emergent. There is debate as to how much progress was are making and what we can do. The challenge cuts across a wide range of domains. Governments and traditional institutions are struggling to rise to the challenge. New ideas are needed. For those interested in these ideas, we believe participatory meeting events could lead to fruitful new ideas and connections. Perhaps low probabilities or very impactful outcomes/meetings. How: The Long-termism UnConference will be a one/two day event bringing together a range of thinkers from a wide range of domains and backgrounds to discuss long-term challenges and solutions in a self-selecting participatory manner. More on me: thendobetter.com/links or @benyeohben Pod: Ben Yeoh Chats
The Question Of Separatism
May 19, 2023 · Original source
… and we think, thank goodness that Germany is unified now. So much easier to think about! Can you imagine if the Our World in Data charts had to show separate lines for the Electorate of Saxony, the Prince-Bishopric of Augsburg, the Duchy of Brunswick-Lüneburg, and about 1,800 other semi-sovereign states? Can you imagine traveling around if each of them had its own currency? (Fun fact: the List of states in the Holy Roman Empire Wikipedia page doesn’t contain such a list. Instead it points to no less than 28 sub-lists.) Jacobs stops shy of asking, in either book, the question that seems to be the logical continuation of her reasoning: should everything be a city-state? Should we encourage separatism until each inhabited place in the world is either a city or a city region with its own currency? We can hazard a guess as to what her answer would be. She would probably say that there’s no need to upend everything right this moment. Just adopt an attitude of political openness and experimentation. Don’t try to hold together entities that don’t work that well. When separatist sentiment arises somewhere, you can argue it’s a bad idea, but don’t fight it out of emotion such as fear for your nation’s integrity. Eventually, things will settle — the regions that want to be city-states will be, and those that prefer to be united with others, for cultural or economic reasons, will stay that way. Unity has good PR and some genuine advantages, so there will still be plenty of it. But maybe Jane Jacobs never asks this question because she knows it’s irrelevant. We just can’t help fighting for our big countries and supranational unions (like the EU), and too bad if they enter long periods of stagflation until they violently collapse. This might be the right time to mention that her last book, published in 2004, is called Dark Age Ahead. IV. Something to Dislike For Everyone Jane Jacobs’s most famous book is The Death and Life of Great American Cities. She is recognized as perhaps the most influential thinker in urbanism. She is credited with saving Greenwich Village and SoHo in New York City, and helping cancel the Spadina Expressway in Toronto. To this day people organize “Jane’s Walks” as a living memorial to her impact on cities. But Jane Jacobs herself thought that her greatest intellectual contribution was not in city planning, but in economics. She thought that import replacement was her most important discovery, since it explained how wealth expands better than existing macroeconomic theories. She wrote multiple books that were explicitly about economics and was about to write another when she died, Uncovering the Economy. I am not an economist, so I might not be qualified to make a judgment on this matter, but: it seems to me that there’s a discrepancy here. Jacobs is widely seen as a great intellectual, but her economic ideas don’t quite seem mainstream. I’d never heard of import replacement before reading her book. Why not? The null hypothesis is that economists have examined her ideas and simply rejected them. There were some critical academic reviews of Cities and the Wealth of Nations when it came out, and more recently Tyler Cowen expressed his own mild skepticism. Some of the criticism involves the lack of quantitative data in her work, and her failure to think about issues of scale. The most obvious target, of course, is her city obsession: yes, cities are important, but they’re not the only economic phenomenon that matters, some would say. Perhaps Jacobs has overplayed her hand. But there are other possible explanations for the discrepancy. One is that she was a woman and had no credentials, which made it difficult for (mostly male) professionals to take her seriously. We know this was true at the beginning of her career at least. It seems possible that even after she managed to establish herself as an original urban thinker, economists had trouble accepting that she could, with her lack of any college degree, come up with new insights in their field. I doubt that’s really true today, though. We do take Jacobs seriously, and still read all of her books, which is more than we could say about most economists. Instead, I propose that the discrepancy comes from a darker place: in laboring to be comprehensive about cities and economics, she reached conclusions that most people don’t want to be true. No matter your politics, there’ll be something for you to dislike in Jacobs’s work. For example, it’s pretty clear that she didn’t think the European Union was a good idea, so she probably would have supported Brexit. Brexiters might rejoice, except that a lot of them are British nationalists who certainly don’t want Scotland to leave the UK, whereas Jacobs would agree with that. Which would be great news to Scottish independentists — except that if a new separatist movement arose within Scotland, she’d also support that. Jacobs’s ideas and grassroots activism in favor of small-scale, organic urban planning have come to be seen as left-wing — yet her criticism of national welfare programs wouldn’t make her out of place among hardcore right-wingers. Unless those right-wingers were military hawks, in which case they’d find no solace in reading Jacobs on military transactions of decline. Writing during the Cold War, Jacobs criticized the Soviet Union for its incredible centralization of decision-making in Moscow. She rightfully predicted its collapse, making her an ideological ally of the capitalist West, right? Not so, since the United States is also, according to her, too centralized and in the early stages of decay. “Today the Soviet Union and the United States each predicts and anticipates the economic decline of the other,” she writes. “Neither will be disappointed.” Whether she was correct about the US is left as an exercise to the reader. In any case, she did foresee, using her theory on cities, the decline of Japan. This must have been bold in the 1980s at the peak of the Japanese economic miracle, when there was a widespread trope that Japan would soon take over the world. Yet she was right: in 1991, Japan entered its “lost decade,” which soon became two lost decades, and then three. To be fair, she predicted the decline of all large-ish countries, so I wouldn’t mark her as a superforecaster or anything. Still, this puts in perspective the more recent trope that China is going to take over the world. No country, no ideology is safe from Jacobs’s prophecies. Smaller ideologies aren’t spared, either. Effective altruism would probably seem totally mistaken to her, since at its core it promotes an inorganic, top-down transfer of wealth from prosperous cities to poor areas. Progress studies people think that technological innovation will solve economic stagnation, but she would point out how labor-saving equipment so often causes damage when it is introduced to regions that don’t benefit from the other city forces, like the Scottish Highlands or many of her other examples in Colombia, India, or the American South. (This point would deserve an essay of its own, but reading Jacobs has made me a bit more worried about the “AI will take our jobs” thing. It’s clear that new jobs will appear, but when the technology city force from the San Francisco Bay Area reaches distant places with poor economies, which it will very soon thanks to the internet, the effects might not be very pleasant to see.) Overall, the political ideology that might fit Jacobs the best might be… libertarianism? She’s not a big fan of large governments who make big top-down decisions, clearly. Yet I don’t get the feeling that this association fits all that well either. Jacobs doesn’t seem to be anti-government if the government is at the city level. I doubt she would have liked the kind of hyperfragmented world depicted in Snow Crash by Neal Stephenson. I also doubt she’d be impressed by cryptocurrency-backed “cloud cities” or fantasies of charter cities, none of which she would see as real cities in the sense of concentrated pockets of people who start replacing what they import with local production. Jane Jacobs, in sum, was an archetypal accidental moderate. She took one idea very seriously — the idea that cities are fundamental — and explored its ramifications without caring in the slightest if it led to the “wrong” opinions, as her friends in 1980 Toronto must have thought when she wrote about Quebec. I don’t know if she went too far; I’m sure someone more qualified than I am can find flaws in that core idea or any of her other observations. But to me she sounds convincing, and her consistency is frankly admirable. So, to end this review on a more review-y note, go read Jane Jacobs. Her books are a delight, with their elegant arguments and masterfully told anecdotes. Her predictions often take an air of doom, but she is also an optimist who offers constructive ways forward. She sets an example for all of us who care about getting the details right, no matter the credentialed experts, the current political climate, or the great theories of the past. Image credits Cities and the Wealth of Nations book cover: from Amazon.
Inline links: List of states in the Holy Roman Empire, https://substackcdn.com/image/fetch/$s_!gyMq!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fdc388f24-009c-42ee-adca-9d5c50faaa66_932x190.png, academic, reviews, expressed, Japan would soon take over the world, fantasies, of, charter, cities, accidental moderate, https://substackcdn.com/image/fetch/$s_!r8Rb!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F60621c76-b34b-4e10-b272-394480443e1b_1600x1066.png, Amazon
What Ever Happened To Neoreaction?
December 07, 2023 · Original source
Progress Studies: Part of the appeal of neoreaction was that the past seemed better at a lot of practical and important things than the present. The 1950s gave us moon missions, the interstate highway system, cheap housing, amazing public infrastructure, and ambitious government programs to end poverty. Nowadays NASA struggles to launch anything without help from SpaceX, the government is too gridlocked for Congress to pass even small tweaks, and the tiniest amount of new infrastructure costs billions and suffers decades-long delays.
Neoreaction noticed these things and concluded that the past was better than the present in full generality, and so we needed to return to the moral sense of the 1700s. I don’t think we should do this. Still, the original observations were sound. I think of Progress Studies as doing some of the hard work of figuring out whether these fields have actually regressed, and if so how we can try to improve them.
But it also pushes a certain aesthetic/psychological package of optimism and pride in human accomplishment, which I really do associate with the past and really do think was one of its best qualities. You can see this in the Progress Studies posts on World’s Fairs and ticker tape parades. Progress Studies does a better job than neoreaction ever did of mourning the loss of this attitude and plotting to get it back. But it correctly identifies it (despite its past-ness) as fundamentally liberal and progressive.
Inline links: World’s Fairs, ticker tape parades
Matt Yglesias Considered As The Nietzschean Superman
July 30, 2024 · Original source
You believe that people should be judged not by their actions, but by the purity of their ideas. Actions are difficult and your actions might be bad, so you definitely don’t want to be judged on those. But ideas are easy, and you can always believe that your ideas are the most pure of all. Also, anyone who acts in the world or achieves something probably is less than 100% slave moralist, so if you judge people based on who has the purest slave moralist ideas, you will always be better than anyone with accomplishments. When I first read Nietzsche, my question was: why worry about the master/slave dichotomy? Sure, maybe this was the way moral codes first formed during the Bronze Age; who cares? You can love excellence and be altruistic. It doesn’t take some Superman to combine them - you can just take the good parts of each. Right? I think Nietzsche would have two answers: First, you don’t pick your moral commitments like foods at a buffet. You deploy them as psychological defense mechanisms. You deploy slave morality when life has beaten you down and you want to maintain some of dignity. You don’t choose which subparts to swallow; you get whichever bits are load-bearing in your personal dignity-maintenance project. And second, you may not be interested in slave morality, but slave morality is interested in you. Master morality isn’t interested in you - the masters are out achieving things and conquering places, they’re not going to take time out of their day to turn missionary and “convert” you to master morality too2. But slave moralists are obsessed with ideological purity and invested in cutting down anybody who’s less slave moralist than they are. Even if you find it easy to avoid yourself, you need to be prepared to live in a slave morality world. V. Jason Crawford Nietzsche’s original dichotomy was aimed at the individual level, where people with psychological drives compete with each other for status. It doesn’t naturally transfer to the idea of societies. There’s a sort of trivial transfer where you can imagine superpowers boasting of their prowess and tiny city-states claiming the geopolitical game is rigged, but that doesn’t seem interesting to me. When I think of master/slave morality at the level of societies, I think of the slave moralist herd instinct to enforce their slave morality on everyone else. This will be a feature of all societies - you could argue it’s what society/civilization is - but some will have it more than others. Jason Crawford, one of the pioneers of Progress Studies, writes about a sort of mid twentieth century vibe shift. In the 19th and early 20th century, Western civilization was busy trying to embiggen itself. Some of this was literal. In America, we had Manifest Destiny, our God-given right to stretch from sea to sea (my sometimes-hometown of Berkeley was named after the guy who coined the slogan “westward the course of empire takes its way”). Europe had colonialism, the White Man’s Burden, and eventually lebensraum. But some of the embiggening was metaphorical. We believed in the cult of progress. We would hold giant World Fairs, where we tiled whole cities with beautiful monuments called things like The Temple Of Machinery or The Altar Of Reason. They would have elaborate friezes of classical goddesses blessing railroads or holding sheaves of mechanically-reaped wheat. Inside, tens of thousands of men would come from every corner of the Earth to behold the newest inventions making our lives richer, safer, and easier. It seemed like we were heading for a Utopia of limitless plenty, and our only responsibility was to bring that great day forward as fast as possible and spread our greatness to as-yet-unenlightened corners of the world like Africa and Tibet. The San Francisco World’s Fair, built in three years (1912 - 1915). The only surviving remnant, the Palace Of Fine Arts (the dome on the lower right), remains one of SF’s most beloved monuments. A picture from the St. Louis, MO World’s Fair of 1904. We erected glorious Art Deco skyscrapers, and boasted of how quickly they went up. We built the Empire State Building in a year and the Golden Gate Bridge in four. The interiors were bursting with color, ornament, and more classical goddesses representing Industry and Ingenuity or whatever. We held ticker tape parades for the glorious aviators and astronauts bringing us to ever-further corners of the world. Art Deco architecture, typical of the early 20th century. After (?) the trauma of the World Wars (?), something flipped. Instead of embiggening ourselves, we began to ensmallen. We replaced World’s Fairs with “World Expos”, which Wikipedia describes as “less focused on technology and aimed more at cultural themes and social progress”. Of the few inventions that did feature, more and more were “green tech” - machines aimed at reducing the damage we were doing to the world. The classical goddesses got replaced by murals of ordinary workers, then abstractions, then nothing. The last ticker tape parade for an individual was 1998; since then the (relatively few, comparatively small) parades have all been for classes of people (NYC’s most recent was for “COVID-19 Essential Workers”). Our buildings became smaller and duller. Last month’s Works In Progress magazine tried to investigate why. Some economists have blamed “Baumol’s cost disease” - as industrialization makes some things (like consumer goods) cheaper, other things (like skilled labor) become relatively more expensive. So maybe the rising cost of skilled labor put buildings like the one of the left out of reach. But Works In Progress found that wasn’t true; if anything, industrialization has made fancy buildings cheaper. They concluded that it was “a story of cultural choice, not of technological destiny” - in other words, people stopped wanting impressive buildings. The vibes were wrong, or something. Intellectuals started feting ideas like degrowth. Degrowth says that it’s gross, greedy, and unsustainable to want economic progress. Instead, we should deliberately aim for economic regress, until First World GDPs are closer to those of South America or Africa. Advocates are careful to emphasize that as long as we take common-sense steps (like implementing socialism), this won’t force anyone to starve to death, just get rid of our useless luxuries - and in some sense, wouldn’t that make us better off?3 The promised future utopia was replaced by almost unbroken dystopianism. Global warming will kill us all, or maybe we’ll be stuck in a cyberpunk world of hopeless soul-crushing inequality. Technological advance is interesting only insofar as it brings our cyberpunk hell closer and (unfairly) enriches some billionaires along the way. The only bright spots are occasional acts of voluntary ensmallening - power plants cancelled, products banned, indigenous tribes winning little legal triumphs over modernity. Live-people goals like “build giant skyscrapers!” and “go to the moon!” could have been followed up with even greater live-people goals like “tile the desert with solar plants”, “create genetically-engineered superbabies”, “get one billion Americans”, or “cure all diseases”. Instead, they’ve been replaced by dead-people goals like “don’t damage the traditional character of communities” or “don’t damage the environment”. If you Google “why aren’t there world’s fairs?” you get a link to this podcast, which explains that they had “useless gizmos”, that the towers were “unattractive”, and that it involved “a dismal thread of racism”. Also because “technology won’t save us”. I agree that this doesn’t literally say the words “we hate all life” - you either see it or you don’t. Parts of this vibe shift still confuse me, but the zoomed-out version seems clear enough. The old pro-embiggening world was complicit in moral catastrophes - racism, colonialism, the Holocaust, the destruction of much of the natural world. At some point these atrocities caught up to and outpaced its very real accomplishments, and society stopped being proud of itself and shifted to a harm-reduction approach. Nobody comes out and says outright that harm reduction necessarily has to mean doing as little as possible and trying to make yourself smaller and less impressive and sadder and uglier until you curl up into a tiny point and disappear. But “slave morality” and “master morality” are attractors; if you select too hard for part of one, you end up with the whole package. VI. Andrew Tate I originally wanted to explain to Bentham’s Bulldog why slave morality wasn’t obviously “the good one” and master morality “the bad one”. Lest I come down too hard and get you thinking that master morality is obviously “the good one”, let’s talk about Andrew Tate. In case you’ve been under a rock your whole life, Andrew Tate is a masculinity influencer. He’s a former world champion kickboxer who pivoted to self-help, sold scammy courses on business and relationships, and got rich. Some of his courses apparently recommended beating up women (I’m not sure if this was supposed to help your business or your relationship), and when people confronted him on this, his response was always “I’m strong and successful and own a Bugatti, which makes me better than you, you pathetic weakling failure”. He was credibly accused of rape (by “credibly” I mean that he sent one of the victims a text message saying “I love raping you”) and when people tried to cancel him over this, his response was always “I’m strong and successful and own a Bugatti, which makes me better than you, you pathetic weakling failure.” Finally he was indicted on one billion counts of sexual assault, human trafficking, and being a general scumbag of a human being; he is currently awaiting trial. Tate has, in some sense, many good qualities. He’s strong, athletic, and motivated. He earned tens of millions of dollars through hustle and hard work. He’s charismatic and compelling and, before his arrest, was one of the Internet’s most iconic influencers. I think master morality has to approve of all these things. Still, he’s obviously a jerk. This is exactly the situation that Nietzsche believes slave morality evolved for - letting me feel contempt for someone who’s stronger and richer and more successful than I am - and yup, now that I’m in this situation, I find myself definitely interested in a moral system that lets me do this. The obvious compromise goes something like: We can genuinely appreciate that Andrew Tate has the many good qualities listed above.
Inline links: 2, writes, World Fairs, https://substackcdn.com/image/fetch/$s_!5vPJ!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F5b5023c4-be4f-427d-a4d1-c8d69ed1fd7b_725x291.png, https://substackcdn.com/image/fetch/$s_!TrEK!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F1c8f847e-4b4f-4388-864a-567849f8f97e.avif, https://substackcdn.com/image/fetch/$s_!rvQM!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fbf261702-dfd3-448e-900f-845a9ef014a4_893x377.png, since then, Last month’s, https://substackcdn.com/image/fetch/$s_!AbVF!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Ff8c33c84-0e6e-4489-8a58-f3603361d7e9_1357x501.png, degrowth, 3, https://substackcdn.com/image/fetch/$s_!7Ttz!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F7589c5dc-2f84-4f82-a6b8-c132ce4a0fc8_697x628.png, this podcast
Altruism And Vitalism As Fellow Travelers
August 06, 2024 · Original source
At this point, I think a vitalism/altruism divergence would look kind of like the progress studies/EA divergence does now - two groups working on similar projects with different emphases, who form natural coalition partners on most topics.
Notes From The Progress Studies Conference
October 24, 2024 · Original source
Tyler Cowen is an economics professor and blogger at Marginal Revolution. Patrick Collison is the billionaire founder of the online payments company Stripe. In 2019, they wrote an article calling for a discipline of Progress Studies, which would figure out what progress was and how to increase it. Later that year, tech entrepreneur Jason Crawford stepped up to spearhead the effort.
Inline links: Marginal Revolution, wrote an article
It seems like you are. Five years later, Progress Studies has grown enough to hold its first conference. I got to attend, and it was great.
The objections failed because Progress Studies is the same type of field as Gender Studies: the Studying serves as the nucleus of a network of scientists, activists, entrepreneurs and journalists working to produce radical change.
Open Thread 414
December 29, 2025 · Original source
1: Tyler Cowen and Patrick Collison are sponsoring A Call For New Aesthetics, $5K - $250K grants to “artists, architects, and designers who are consciously working to define” a new aesthetics for the 21st century. Seems crazy ambitious, but that’s what people said about Progress Studies, and that one worked, so this duo has earned my trust. But please do me a favor and only apply if your aesthetics are good. It would be a shame if they put in all this work, and we just got another hundred years of bad aesthetics.
Inline links: A Call For New Aesthetics
prediction markets8 mentions across 8 issues

prediction markets is a recurring concept in the Astral Codex Ten archive, appearing 8 times across 8 issues between November 15, 2021 and July 08, 2025. The archive places it in contexts such as "conditional prediction markets"; "prediction markets seem maybe good"; "like prediction markets, initial coin offering style funding schemes". It most often appears alongside Donald Trump, Metaculus, Polymarket.

Article page
prediction markets
Mention count
8
Issue count
8
First seen
November 15, 2021
Last seen
July 08, 2025
Outbound links
Issue trail
Related pages
Source context
15
November 15, 2021 · Original source
They focus not just on long-run outcomes but on conditionals and counterfactuals. The paper starts with an argument against conditional prediction markets that I’d somehow missed before. Suppose you want to know whether a mask mandate will save lives during a pandemic. Current state of the art is to start two prediction markets: “conditional on there being a mask mandate, how many people will die?” and “conditional on there not being a mask mandate, how many people will die?” In this situation, this doesn’t work! Governments are more likely to resort to mask mandates in worlds where the pandemic is very bad. So you should probably predict a higher number of deaths for the mandate condition. But then confused policy-makers will interpret your prediction market as evidence that a mask mandate will cost lives.
Overall, I’m really excited by this. My only concern is that it doesn’t have the same sort of hits-you-between-the-eyes obviously-there’s-no-way-to-bias-this quality that prediction markets do. If these people had predicted the effects of COVID restrictions before COVID, people would have doubted them for the same reason they doubted the ordinary experts.
Prediction markets reached near-certainty about the winner while traditional media was still talking about how un-call-ably close it was. Apparently having hundreds of people all incentivized to give precise probability estimates very slightly earlier than the next guy, works better than having a few journalists who are scared people will make fun of them if they jump the gun.
Movie Review: Don't Look Up
January 04, 2022 · Original source
What do you do? I guess you do the principled philosophy thing. You collide the two narratives, integrate them, and try to build something useful out of the debris, while constantly being tripped up by fuzzy boundaries and edge cases. The rationalist community has been trying this for fifteen years, and so far what we’ve got is some combination of “these math lectures describe what to do perfectly in theory, shame we disagree on how to apply them to the real world” and “prediction markets seem maybe good” and “turns out the people who obsess over this are often trustworthy on object-level questions” . Other people have been chipping away at the same question for longer and developed Arts of their own, but no one seems fully satisfied.
The Passage Of Polymarket
February 07, 2022 · Original source
Polymarket is probably the biggest prediction market currently available. US law considers unlicensed prediction markets to be somewhere between illegal gambling and illegal futures trading, ie definitely illegal. Polymarket and a few peers had survived anyway, through the “crypto is the Wild West and nobody has time to deal with all the illegal things happening there” exemption. Apparently they found time.
The rumor on the prediction market grapevine (which I absolutely cannot substantiate; please don’t sue me for libel) is that this might have something to do with competing prediction market Kalshi. Kalshi spent two years and probably a lot of money getting the CFTC to agree they were legal, and has a former CFTC Commissioner as a Director. Their legal status forces them to do an annoying and expensive regulatory dance all the time; illegal prediction markets were able to move more nimbly, provide better user experience, and eat their lunch. This was a big problem for them - but they’d just finished making lots of friends in the agency that decides which illegal things to crack down on, so, as Tyler Cowen likes to say, “solve for the equilibrium”.
Inline links: rumor, two years, has a former CFTC Commissioner as a Director
Throughout these bad decisions, intelligence analysts and national security advisors were begging the government to come up with some kind of good forecasting infrastructure. By the early 2000s, many of them had settled on prediction markets as the most promising opportunity. In 2008, twenty-two prominent economists including five Nobel Prize winners wrote an editorial begging the CFTC to legalize prediction markets; the CFTC refused. In 2010, Philip Tetlock (one of the signatories on the pro-prediction market letter) did some pretty basic forecasting work, not even prediction market level, and proved that he could significantly outperform top analysts at the CIA with access to classified information. The government refused to hire him or use any of his methods, and continued shutting down new prediction markets as they arose.
My California Ballot 2022
November 04, 2022 · Original source
The argument in favor is that in a world where you can already buy stocks and crypto, I’m not sure sports gambling makes things any worse. And I’m hopeful that this would set a precedent that could one day lead to legalization of prediction markets.
Prediction Market FAQ
December 20, 2022 · Original source
This is a FAQ about prediction markets. I am a big proponent of them but have tried my hardest to keep it fair. For more information and other perspectives, see Wikipedia, the scholarly literature (eg here), and Zvi.
Inline links: Wikipedia, here, Zvi
1. What are prediction markets? 2. Why believe prediction markets are accurate? 3. Why believe prediction markets are canonical? 4. What are the most common objections to prediction markets? 5. What are some clever uses for prediction markets? 6. What’s the current status of prediction markets? 7. What can I do to help promote prediction markets?
Inline links: What are prediction markets?, Why believe prediction markets are accurate?, Why believe prediction markets are canonical?, What are the most common objections to prediction markets?, What are some clever uses for prediction markets?, What’s the current status of prediction markets?, What can I do to help promote prediction markets?
1. What are prediction markets? 2. Why believe prediction markets are accurate? 3. Why believe prediction markets are canonical? 4. What are the most common objections to prediction markets? 5. What are some clever uses for prediction markets? 6. What’s the current status of prediction markets? 7. What can I do to help promote prediction markets? 1. What are prediction markets? Prediction markets are like stock markets, but for beliefs about future events. For example, you can buy or sell shares in events like “The Democrats will win the next election” or “A Category 5 hurricane will hit Florida this year”.
Inline links: What are prediction markets?, Why believe prediction markets are accurate?, Why believe prediction markets are canonical?, What are the most common objections to prediction markets?, What are some clever uses for prediction markets?, What’s the current status of prediction markets?, What can I do to help promote prediction markets?
Open Thread 258
January 08, 2023 · Original source
6: Also, many, many of you commented that Bob and Ramchandra were just “reinventing the wheel” and antistocks were the same as some existing financial product, although none of you could agree on which existing product it was. See the cases for bucket shops, call options, equity swaps / total return swaps, dividend derivatives, and (inevitably) prediction markets. Also, several people chimed in to say they were working on something similar on the blockchain, including Tracer and Synthetix. I hope I don’t need to add the disclaimer that if you invest in a blockchain product based on a Bay Area House Party post, then you will lose all your money faster than anyone has ever lost all of their money before in all of history.
Inline links: bucket shops, call options, equity swaps / total return swaps, dividend derivatives, prediction markets, Tracer, Synthetix
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August 28, 2023 · Original source
Sorry guys, LK-99 doesn’t work. The prediction markets have dropped from highs in the 40s down to 5 - 10. It’s over.
Inline links: LK-99 doesn’t work
What does this tell us about prediction markets? Were they dumb to ever believe at all? Or were they aggregating the evidence effectively, only to update after new evidence came in?
NinthCause and SG are Manifold co-founders. Jack, Marcus Abramovich, and Michael Wheatly are Manifold leaderboard record holders. Peter Wildeford is a superforecaster who came near the top in the ACX forecasting contest. Matthew Barnett works in AI forecasting. You all know Eliezer and Zvi. As far as I can tell nobody high up on the YES side is similarly illustrious. But prediction markets are supposed to ensure you don’t have to resort to name-dropping, so how did this go wrong? I was tempted to blame Manifold-specific factors, like the ability to get starting mana instead of putting skin in the game. But real-money markets Polymarket and Kalshi got approximately the same results: Polymarket: https://polymarket.com/event/is-the-room-temp-superconductor-real Kalshi: https://kalshi.com/markets/supercon/roomtemp-superconductor-reported Both reached the 40s to 50s! I think there just wasn’t enough smart money to drown out the people who wanted to bet on an exciting thing being true, or who were unduly influenced by a social media environment optimized to keep their attention by convincing them that an exciting thing was true. I have never claimed prediction markets are always good. All I wrote in the Prediction Market FAQ was that either a prediction market will be good, or you could make lots of free money. In this case, it was the second one. I regret I only made $30. I do hope this situation will improve over time, as over-eager forecasters get burned and dollars flow from dumb money to smarter. [EDIT: I should have included something about Metaculus here, but it’s confusing. I think the most popular Metaculus market was lower because it had stricter resolution criteria (the first replication had to be positive, instead of any replication) but that otherwise Metaculus raw probabilities mirrored everyone else’s. We don’t know how their algorithmically processed probabilities did yet and I’ll report on that information when I get it.] Salem/CSPI Tournament Winners The Salem Center and the Center For The Study Of Partisanship And Ideology, two think tanks associated with right-wing intellectual Richard Hanania, sponsored a prediction market tournament last year. Participants got $1000 in play money to bet on selected markets about current events; winners would be interviewed for a well-paying academic sinecure at one of the think tanks. Now the tournament is over. Winners have yet to be announced, but unofficially, everyone knows who they are: First place out of 999 participants is zubbybadger. Zubby is a prediction market veteran who was featured in a Washington Monthly article last year for his great track record in political betting (he’s made > $150,000 on PredictIt). Now he works as a “community manager” for Kalshi (I don’t know what this entails). Second place was Robert from Considerations On Codecrafting. He’s written a detailed reflection on his experience (part one, part two) which is my main source for this section and highly recommended. He describes himself as “having absolutely no experience with prediction markets”. Third place was Johnny Ten-Numbers, about whom I can find no further information. You can see the rest of the top 20 at the very bottom of this post. Reading Robert’s story of his experience, I’m struck by how little of the competition at the top was about predictive accuracy. Everyone in the top 20 was a very accurate predictor (Exactly equally accurate? Hard to tell.) What separated 1st place from 20th, aside from luck, was things like: Ability to move fast - both in responding to news, and in taking the other side of bad bets. Several top performers programmed bots to give them an edge here.
Inline links: https://polymarket.com/event/is-the-room-temp-superconductor-real, https://substackcdn.com/image/fetch/$s_!PMh_!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F1143f4c9-a7f7-4aee-a006-12b1a28bd923_654x389.png, Prediction Market FAQ, selected markets about current events, zubbybadger, featured in a Washington Monthly article last year, Robert, part one, part two, Johnny Ten-Numbers
Now I Really Won That AI Bet
July 08, 2025 · Original source
On prediction markets, where users had given 62% probability that Edwin would grant me the win that year, reactions were outraged. “Are you kidding me?” asked one commenter. “Is Edwin Chen an asshole? Clearly he is,” said another.
Inline links: reactions were outraged
I tried to contact Edwin for confirmation, without success. I wondered what had happened to him, and a quick search found that his AI data-labeling company did very well and he’s now probably a billionaire. I hope he’s relaxing on a yacht somewhere, far away from angry prediction market commenters.
Inline links: his AI data-labeling company did very well and he’s now probably a billionaire
Protestantism7 mentions across 7 issues

Protestantism is a recurring concept in the Astral Codex Ten archive, appearing 7 times across 7 issues between April 21, 2021 and August 01, 2025. The archive places it in contexts such as "almost a fifth of Latin Americans have converted to Protestantism"; "Protestantism heavy on the plainness"; "Catholicism/Orthodoxy and most Protestantism". It most often appears alongside Catholicism, Africa, China.

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Protestantism
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No, Really, Why Are So Many Christians In Colombia Converting To Orthodox Judaism?
April 21, 2021 · Original source
And if we’re going to include Judaism and Eastern Orthodoxy, we might as well talk about the five million Mormons in Latin America, or the thing where almost a fifth of Latin Americans have converted to Protestantism in the past fifty years.
Inline links: the five million Mormons in Latin America, almost a fifth of Latin Americans have converted to Protestantism in the past fifty years
Still, Orthodox Judaism? The articles linked above talk about why Mormonism and Pentecostalism are winning converts in Latin America. Both put lots of effort into missionary work (Judaism actively discourages conversion). Pentecostalism in particular is hip and willing to adapt itself to Latin American culture in a way that Catholicism isn’t - “The music that you hear in Pentecostal churches has the same rhythms that people enjoy outside of church” (Orthodox Judaism is about the least-hip and least Latin-American-culture-compatible religion imaginable). The number one reason cited by new Latin American converts to Protestantism is that they are “seeking a personal connection with God” (Orthodox Judaism almost aggressively avoids providing this). And converting to Orthodoxy is not a small step:
Inline links: actively discourages conversion, willing to adapt, number one reason
Whither Tartaria?
September 23, 2021 · Original source
Catholicism traditionally goes heavy on the ornateness, Protestantism heavy on the plainness. Something to do with a Protestant rejection of wealth as too linked to the powers of this world, and trying to get back to the poverty and humility of the original Church. If Protestant aesthetics "won" in a way that affected even people who weren't thinking in religious terms, that could explain some of the shift.
Highlights From The Comments On Columbus Day
October 10, 2022 · Original source
The implications of Arianism for Mariology, which provides a sharp distinction between Catholicism/Orthodoxy and most Protestantism, are huge. If you're debating Mary's role in salvation, which we Catholics/Orthodox think is major and most Protestants don't (and which we fight about on the internet the way you fight about buying mosquito nets) you eventually run into the Christological answer given by Arius. If Jesus isn't fully God, then Mary can't be the mother of God, which we think is an important title, with a corresponding entitlement to special reverence.
Links For May 2023
June 01, 2023 · Original source
I would instead put this in the context of the centuries-long advance of Protestantism. Martin Luther said that instead of asking priests what they thought a holy book said, you should study it yourself. But this still left a potential weak point - institutions can convince you to interpret the book in the way they prefer. Now we’ve finally brought the Lutherian project to its ultimate conclusion, where you can cut out the personal interpretation and just ask the sacred text directly. Of course no one likes how it answers!
Your Book Review: The Weirdest People in the World
August 11, 2023 · Original source
Y is correlated with X today Indeed this does seem to skip all the interesting, contingent bits: On the other hand, if you want to explain an all-important outcome like the take-off into modern economic growth, then you can't just mumble “one damn thing after another” or “irony and contingency”. That a hundred things randomly conspired to make the West Educated, Industrialized, Rich and Democratic is not a satisfying story. Why would the die rolls keep favouring this one place? (And you can't invoke the law of large numbers. There are only five continents in the world, and modern economic growth did not have to happen anywhere at all.) To get from Europe 1 AD to modernity, while paying reasonable attention to the many accidents along the way, there are really only two possible narrative genres. The first is the rock falling down a mountain. It starts with one big, random event. This then triggers other events, and they trigger others, and now you have an unstoppable landslide. But the chance is at the start. The second is the cyclist pushing his bike up a mountain. It takes an actor who deliberately over time overcomes one obstacle and dodges another, until eventually they get to the top, and from there it's a downhill ride. WEIRD belongs firmly in the landslide genre. The big event is the Marriage and Family Program of the Western Church. This sets off a landslide, which the later chapters detail: the decline of kin institutions, the rise of Italian communes and city-states in the middle ages, the idea of individual rights in the European law merchant, the development of Protestantism, and finally the trifecta of science, commerce and democracy. WEIRD psychology is there, as an unobserved helper, for each stage of this journey, but each stage also builds on the previous ones. It's not by chance that WEIRD tells the West's story as a landslide. First, this is part of cultural evolution's baggage of intellectual commitments. Homo culturalis doesn't figure out solutions to his problems by abstract thought; he's not a natural optimizer. Instead he feels his way towards solutions. In a now famous example from The Secret Of Our Success, nobody just sat down and worked out how to detoxify manioc. Cultures which did this job better just had an evolutionary advantage. Second, the “bicycle push uphill” story would threaten the clean causality of the natural experiment. Suppose the Western Church promulgated the MFP with the deliberate plan of creating WEIRD psychology and causing the take-off into modern economic growth. Okay, that's unlikely, but suppose it promulgated the MFP with a plan that was somewhat related to increasing human welfare (in this world, not the next). Then we might suspect two things: Maybe in doing so the Church was reacting to existing conditions: reading the human situation and responding “hey, what we need here is less intensive kinship”.
Inline links: detoxify manioc
There’s the research programme of the psychology of religion, most famously exemplified in Ara Norenzayan’s Big Gods, with its human-like agents, divine monitoring, and Credibility Enhancing Displays. There’s the WEIRD kinship complex of bilateral descent, little to no cousin marriage, monogamy and nuclear families. There’s the history of the medieval church and its Marriage and Family Program, including the historical linguistics of words for relatives. There’s a big set of cross-country or cross-region regressions on “kinship intensity” – how clannish a society is – WEIRD pychology, the genetics of inbreeding and diplomats’ unpaid parking tickets. There’s the story of monogamy, how it affects testosterone, and how that might affect trust and conflict. There’s historical economic studies, usually with some clever natural experiment, on the medieval growth of institutions like fraternities, monasteries, universities, charter towns and the Law Merchant; and the plausible role of WEIRD psychology in each of these. Then the history of clocks, work hours, Cistercians, interest rates and apprenticeships. Last of all the development of law, science and Protestantism, again always with WEIRD psychology as a possible contributor, especially in building the networks – the collective brain – underpinning innovation. Across all of these areas, Henrich is always ready to jump sideways, to use a modern psychology experiment or a tribal ethnography to cast light on European history.
Against The Cultural Christianity Argument
October 04, 2024 · Original source
But the Christian cultural package also fell apart and became the current post-Christian world. This wasn't just a one-time coincidence either. Protestantism gave way to modernism in Scandinavia, Germany, and the US. Catholicism gave way to modernism in Spain, Italy, and Latin America. Orthodoxy gave way to modernism in Greece, Eastern Europe, and Russia (with a slight Putinist resurrection-in-name-only which hardly seems to have produced a flourishing liberal society). Meanwhile in China, the local mix of Buddhism/Confucianism/Taoism gave way to modernism. In South East Asia, Buddhism gave way to modernism. Only 10% of Israeli Jews are ultra-Orthodox, and it would be lower if they didn't breed so fast. India is moderately Hindu but still noticeably modern. Even the Middle East is gradually becoming less Muslim.
Your Review: Joan of Arc
August 01, 2025 · Original source
Obviously, if you're a Catholic, you can be content with the first model, and indeed can be very smug that is exactly what your religion would predict. Non-Catholic Christians might want to consider switching sects, or just might want to say that Joan is before Protestantism and we don't know what she would have thought of it.92
Inline links: 92
postmodernism5 mentions across 5 issues

postmodernism is a recurring concept in the Astral Codex Ten archive, appearing 5 times across 5 issues between January 29, 2021 and December 04, 2024. The archive places it in contexts such as "isn't that usually code for stuff like queer theory, postcolonial theory, and postmodernism?"; "Postmodernism is closer to the correct timeframe, but it started in Europe"; "the book ... tussles with postmodernism". It most often appears alongside America, Harvard, US.

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postmodernism
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Contra Weyl On Technocracy
January 29, 2021 · Original source
And would Weyl's suggestions really help prevent populist backlashes? He wishes we abandoned our overly-rational ways in favor of "humanities, Continental philosophy, and the humanistic social sciences" - isn't that usually code for stuff like queer theory, postcolonial theory, and postmodernism? Are working-class Trump supporters really banging on their keyboards when they read about effective altruism, shouting "YOU NEED TO STOP TRYING TO BE OBJECTIVE AND FACT-BASED, AND BE MORE OPEN TO INSIGHTS FROM QUEER THEORY AND POSTMODERNISM"?
Highlights From The Comments On Bobos In Paradise
December 09, 2022 · Original source
* Postmodernism is closer to the correct timeframe, but it started in Europe. Furthermore, the concept of a meritocracy determined by standardized testing is *much* closer to High Modernism than premodern elites, and some serious explanation would be needed for this meritocratic elite to be the ones that turned against meritocracy.
Your Book Review: The Pale King
September 06, 2024 · Original source
For the longest time, I avoided reading The Pale King. It wasn’t the style—in places thick with the author’s characteristic footnotes,1 sentences that run for pages, and spasms of dense technical language. Nor was it the subject matter—the book is set at an IRS Center and tussles with postmodernism. Nor the themes, one of which concerns the existential importance of boredom, which the book, at times, takes pains to exemplify.
Inline links: 1
1) How to transcend postmodernism
Postmodernism can be understood as the idea that we’re so trapped within language that reality remains remote. At its most extreme, postmodernism seems to suggest that language is all that exists. In politics, this manifests as movements that focus on how people speak, much more than movements of the past; and in literature, as writing that aims not to immerse the reader in a plausible world, but to keep the reader hyper-focused on the fact that they’re reading a work of fiction. Wallace began his literary career as a postmodernist,4 before swerving away mid-career, most dramatically with Infinite Jest.
Inline links: 4
Against The Cultural Christianity Argument
October 04, 2024 · Original source
Only two things block me from becoming a Cultural Theist. The first is boring: I hate asserting false things, even if they're "practical". I don't ask anyone else to share that particular quirk. So I find the second more interesting: the Cultural Christianity argument hinges on the proposition that all liberal societies without Christianity will eventually collapse into wokeness and postmodernism. But Christianity also eventually collapsed into wokeness and postmodernism. So if they're both equally doomed, why not at least be truthful by advocating for the virtuous liberal society I wanted in the first place?
That is, suppose I were to advocate a return to 1890s norms of (let's say) liberalism and beautiful art. The Cultural Christian would tell me this is doomed, because the 1890s cultural package eventually fell apart and became the 20th century cultural package of wokeness and postmodernism (and fascism, socialism, New Dealism, etc). Therefore, I should support Christianity.
I am no fan of medieval theocracy. But I do have a weakness for the 1880 - 1930 period of fin de siecle culture, Art Nouveau, economic liberty, and progressophilia. This period wasn't very religious - Nietzsche had already declared God dead in 1882. But the Cultural Christians would argue that such a flowering of culture and optimism could only happen within a generation or two of a Christian society. It (they would argue) contained the seeds of its own destruction, doomed to degenerate into our current postmodernist brutalist whatever. If I want the 1890s back, I shouldn't advocate the (mostly classically liberal) positions of the 1890s. I should advocate for Christianity, the only ideology under which something like those positions can be stable.
Book Review: From Bauhaus To Our House
December 04, 2024 · Original source
Wolfe ties this to the contemporaneous rise of pop art. Modern art and architecture were founded in the rejection of bourgeois notions of beauty, in favor of a faux-proletarian idea of simplicity and scientificness. But, Venturi pointed out, proletarians were kind hard to find in c. 1970 America. Grounding your class analysis in a non-existent proletariat seemed kind of out-of-touch, and so - perhaps - bourgeois. Who actually existed? The middle class. And what did the middle class like? Mass market consumer slop. Therefore, the true foundation of Art should be mass market consumer slop. Of course, since artists are superior to the middle class, it should be some sort of extremely complicated reference to mass market consumer slop which makes it clear that the artist themselves is infinitely above such things (but also, what if they weren’t above it, because they were so in-touch with normal people (but also, obviously they’re infinitely above it (but also, what if they weren’t))) . . . and so on. This tendency eventually became postmodernism with all its layers of irony and self-reference.
In architecture, postmodernism relaxed the constraint that every building had to be a box, in favor of buildings that were “playful” and tried to “undermine” traditional notions of form and shape:
Postmodern buildings were allowed to include some traditional elements and ornamentation, but only to refer to them ironically, confuse people about them, or mock them.
predictive coding5 mentions across 5 issues

predictive coding is a recurring concept in the Astral Codex Ten archive, appearing 5 times across 5 issues between March 26, 2021 and February 26, 2026. The archive places it in contexts such as "the predictive coding community uses a different one"; "Predictive coding is the most plausible current theory of how the brain works"; "First of all - predictive coding identifies suffering with prediction error". It most often appears alongside 5-HT1A, 5-HT2A, active inference.

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predictive coding
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5
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5
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March 26, 2021
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February 26, 2026
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Toward A Bayesian Theory Of Willpower
March 26, 2021 · Original source
The economic metaphor here is cute, but the predictive coding community uses a different one: they describe it as representing the "confidence" or "level of evidence" for a specific calculation. So an alternate way to think about lampreys is that the flee-predator region is saying "I have VERY VERY strong evidence that fleeing a predator would be the best thing to do right now." Other regions submit their own evidence for their preferred tasks, and the basal ganglia weighs the evidence using Bayes and flees the predator.
Inline links: predictive coding
[LINK] Unifying Predictive Coding With Backpropagation
April 14, 2021 · Original source
[epistemic status: I know a little about the predictive coding side of this, but almost nothing about backpropagation or the math behind the unification. I am posting this mostly as a link to people who know more.]
This is a link to / ad for a great recent Less Wrong post by lsusr, Predictive Coding Has Been Unified With Backpropagation, itself about a recent paper Predictive Coding Approximates Backprop Along Arbitrary Computation Graphs.
Inline links: Predictive Coding Has Been Unified With Backpropagation, Predictive Coding Approximates Backprop Along Arbitrary Computation Graphs
Predictive coding is the most plausible current theory of how the brain works. I’ve written about it elsewhere, especially here.
Inline links: here
Carhart-Harris On Serotonin
June 15, 2021 · Original source
First of all - predictive coding identifies suffering with prediction error. This conflicts with common sense. Suppose I tell you I'm going to stab you in the arm, you agree that I'm going to stab you in the arm, and then I stab you in the arm, and it hurts a lot. You predicted what would happen correctly, but you still suffered. The theory resolves this with a distinction between common-sense-level and neurological predictions: your brain is "set" to expect normal neurological feedback from your arm, and when it gets pain signals instead, that's a violated prediction, and this is the level on which prediction error = suffering. But there are other cases where the common-sense and neurological sense of predictions are more congruent. When you first step into a cold shower, you feel suffering, but after you've been in it a while you adjust your "predictions" and it's no longer as unpleasant. If you unexpectedly lost $25,000 it would come as an extremely unpleasant shock, but when you predictably have to pay the taxman $25,000 each year you grumblingly put up with it.
Singing The Blues
January 03, 2024 · Original source
I’ve previously endorsed predictive coding theories of depression and other illnesses. How does that interact with this perspective? This is even more speculative than the rest, and I don’t feel like I entirely get it, but here’s the completion my internal pattern-generator has spit out:
Many of the claims of predictive coding can be rephrased as claims about control theory, and vice versa. You have to slightly fudge things to make this work on homeostatic bodily processes, but this is the kind of fudging that Karl Friston has already worked into his free energy concept.
Inline links: Many of the claims of predictive coding can be rephrased as claims about control theory, free energy
In predictive coding, the equivalent of control theory’s “set point” is the “prior”. This suggests an elegant equivalence: an incorrectly fixed set point, like those in anorexia and depression, are the same thing as a trapped prior.
Inline links: a trapped prior
Next-Token Predictor Is An AI's Job, Not Its Species
February 26, 2026 · Original source
In neuroscience, predictive coding (also known as predictive processing) is a theory of brain function which postulates that the brain is constantly generating and updating a “mental model” of the environment. According to the theory, such a mental model is used to predict input signals from the senses that are then compared with the actual input signals from those senses.
These algorithms are a second optimization loop, “evolving” neuron patterns into forms that better promote fitness, reproduction, etc. The most powerful such algorithm is called predictive coding, which neuroscience increasingly considers a key organizing principle of the brain. Wikipedia describes it as:
Inline links: predictive coding, Wikipedia describes it as
psilocybin5 mentions across 5 issues

psilocybin is a recurring concept in the Astral Codex Ten archive, appearing 5 times across 5 issues between December 17, 2024 and November 24, 2025. The archive places it in contexts such as "Some psychedelics, especially psilocybin and DMT"; "Any adult can replicate it with five milligrams of psilocybin"; "This effect is basically identical to what a small dose of psychedelics can do, specifically a tryptamine like psilocybin". It most often appears alongside DMT, FDA, AI.

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psilocybin
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5
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5
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December 17, 2024
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November 24, 2025
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  • DMT 3 shared issues
  • FDA 3 shared issues
  • AI 2 shared issues
  • anime 2 shared issues
  • Bluesky 2 shared issues
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Links For December 2024
December 17, 2024 · Original source
13: Alfredo Parra of Qualia Research Institute on cluster headaches. Cluster headaches are plausibly the most painful medical condition. If you ask a cluster patient to rate their pain, they’ll almost always say 10/10. Does that mean the headaches are twice as painful as a 5/10 condition? There are some philosophical reasons to expect pain to be logarithmic, so plausibly cluster headaches could be orders of magnitude more painful than the average condition. Once you internalize that possibility, it throws a wrench into normal QALY ratings and suggests that, even though cluster headaches are pretty rare, they might cause a substantial portion of the global burden of disease (or even a substantial portion of the suffering in the world). Some psychedelics, especially psilocybin and DMT, seem to treat cluster headaches very effectively, so the more you believe this reanalysis, the more interested you should be in figuring out how to turn these into an accessible therapy (see clusterbusters for more information on this aspect).
Inline links: Alfredo Parra of Qualia Research Institute on cluster headaches, pain to be logarithmic, clusterbusters
The Colors Of Her Coat
April 01, 2025 · Original source
And the ease with which Chesterton navigates this interpretation - the way he makes it the most natural thing in the world - made me wonder - what if Chesterton is also just describing his experience completely accurately? The thousandth sunset thing is so prominent in his works, and he never expresses any embarrassment about it, never says anything like “a saint would be able to do this, although of course I cannot”. If anything, the mood is one of mild exasperation that nobody listens to him. This sort of thing would make complete neurological sense - it’s just an increase in the precision of sensory evidence relative to top-down priors. Young children do it naturally - as any parent can tell you after having to read their one-year-old the same book for the thousandth time. Any adult can replicate it with five milligrams of psilocybin or a few dozen hours of samatha meditation. Who’s to say you can’t get it through genetics? Or through being very holy?
Inline links: the precision of sensory evidence, five milligrams of psilocybin, a few dozen hours of samatha meditation
Links For July 2025
July 01, 2025 · Original source
7: Related: Cube_Flipper on his (?) experience taking estrogen. “What did change was my sense of space. This one’s quite subtle – it was the kind of thing that was more noticeable when I experimented with deliberately spiking my hormones. I’ll do my best to explain. It’s as if I took the entire volumetric representation of the space around me and increased the degree to which every point within that could influence the location of every other point, recursively. This allows everything to elastically settle into a more harmonious equilibrium. This effect is basically identical to what a small dose of psychedelics can do, specifically a tryptamine like psilocybin or DMT.”
Inline links: Cube_Flipper on his (?) experience taking estrogen
ACX Grants Results 2025
October 13, 2025 · Original source
Eli Elster, $13K, to research traditional psilocybin use in Africa. Psilocybin, aka magic mushrooms, is in the process of being integrated into mainstream psychiatric practice; it is already approved for treatment-resistant depression in Australia, and undergoing (currently promising) FDA trials in the United States. Much of what we know about the preparation and administration of psilocybin - including widespread ideas about “set and setting” and “integration” - comes from traditional use by the Mazaetec Indians. In 2023, anthropologists discovered that traditional healers in Lesotho, Africa also use psilocybin mushrooms - the first time such a practice has been found in the Old World - and that they seem to prepare and administer it differently from the Native Americans. Eli and his collaborator Betsy Sethathi conducted the first in-depth fieldwork on the topic earlier this year; our grant funds a return trip to Lesotho to further investigate their ethnobotanical practices and see if we can learn anything from them.
Inline links: Eli
Open Thread 409
November 24, 2025 · Original source
2: Qualia Research Institute announces their spinoff effort ClusterFree. Cluster headaches (aka “suicide headaches”) are probably the most painful medical condition known to science, which makes them a natural priority for some utilitarians. They seem to be extremely treatable by psychedelics like psilocybin and DMT (including sub-hallucinogenic doses), so ClusterFree is working on getting governments to research this further and maybe get these drugs into the medical pipeline (cf. ketamine for depression). There’s an open letter here, and you can contact them here. The information for patients is at the bottom of this page.
Inline links: ClusterFree, some, open letter here, here, this page
Pascal’s Wager4 mentions across 4 issues

Pascal’s Wager is a recurring concept in the Astral Codex Ten archive, appearing 4 times across 4 issues between November 24, 2021 and June 28, 2024. The archive places it in contexts such as "we’ll wish we’d stopped Pascal’s Wager-ing drug decisions at some earlier point"; "His daughter attributed her father’s “change of heart” to Pascal’s Wager"; "by reference to Pascal’s Wager". It most often appears alongside Alexandros Marinos, America, COVID.

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Pascal’s Wager
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4
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4
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November 24, 2021
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June 28, 2024
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Pascalian Medicine
November 24, 2021 · Original source
Another way of looking at this is that I must think there’s a 25% chance Vitamin D works, and a 10% chance ivermectin does. Both substances are generally safe with few side effects. So (as many commenters brought up) there’s a Pascal’s Wager like argument that someone with COVID should take both. The downside is some mild inconvenience and cost (both drugs together probably cost $20 for a week-long course). The upside is a well-below-50% but still pretty substantial probability that they could save my life.
Inline links: Pascal’s Wager
So if you’re an onion farmer, and you have a bunch of extra onions you can’t sell one year, all you have to do is ask some scientist friends to study whether onions cure cancer. There will be a bunch of studies, lots of them will be sloppy and say yes, people like me will see a bunch of positive studies and say “Can I really be more than 99% sure this is false? and if there’s even a 1% chance onions cure cancer, then - given how safe they are - isn’t it worth trying?” And then doctors will make every cancer patient take concentrated onion extract every day. Then eggplant farmers will want in on the money-printing-license, and then pumpkin farmers, and soon we’re up to 100 pills a day instead of just twenty. And then we’ll wish we’d stopped Pascal’s Wager-ing drug decisions at some earlier point. And maybe the right point to stop is now.
Book Review: The Man From The Future
July 13, 2022 · Original source
Still, he had the presence of mind to make a last request: after a lifetime of culturally-Jewish atheism, he wished to be baptized. His daughter attributed her father’s “change of heart” to Pascal’s Wager: the idea that even a very small probability of gaining a better afterlife is worth the relatively trivial cost of a deathbed conversion. Even as his powers deserted him, John von Neumann remained a game theorist to the end.
Response To Alexandros Contra Me On Ivermectin
February 01, 2023 · Original source
Alexandros has previously stressed that he doesn’t mean to express certainty that ivermectin works. He calls his style of reasoning Omura’s Wager, by reference to Pascal’s Wager. If you use ivermectin, and it doesn’t work, then you’ve wasted your time and maybe gotten a few minor side effects. If you don’t use ivermectin, and it does work, then you’ve missed out on a potentially life-saving medication. Therefore (he concludes) given even a little remaining uncertainty about whether ivermectin works, you should use it.
Your Book Review: Dominion
June 28, 2024 · Original source
As to whether God actually wants us to be kind to animals, we can never really know. But in a Pascal’s wager sort of way, it seems like a good bet to extend love to our furry, feathery, scaly, and even chitin-y friends just in case.
psychology4 mentions across 4 issues

psychology is a recurring concept in the Astral Codex Ten archive, appearing 4 times across 4 issues between April 22, 2021 and February 27, 2025. The archive places it in contexts such as "borrows much from psychology, neuroscience, and evolutionary biology"; "I feel like psychology is the same way"; "before the Federal money started streaming to my field, psychology". It most often appears alongside Scott Aaronson, /r/NootropicsDepot, @fae_dreams.

Article page
psychology
Mention count
4
Issue count
4
First seen
April 22, 2021
Last seen
February 27, 2025
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Source context
Your Book Review: Are We Smart Enough To Know How Smart Animals Are?
April 22, 2021 · Original source
Are We Smart Enough gives an overview of the study of animal cognition, its history, past and current controversies, and where the field might go next (as of 2016). "Animal Cognition" is a relatively new subfield that borrows much from psychology, neuroscience, and evolutionary biology, but it is firmly rooted in its parent field of ethology. So, just what is ethology? It is the study animal behavior. Ethologists these days are certainly knowledgeable about evolutionary lineages, cladistics, and animal anatomy, but the heart of the field has always been observing animals interacting with their environments (whether a wild or experimental environment). As we'll see, it's a field with a history at least as tumultuous as psychology, with an early amateurish "wild west", a strict over-correction, and these days a hopefully more productive synthesis.
De Waal closes by acknowledging that the field has come around and these days, with animal cognition a respected field and the assumption of evolutionary continuity it rests on widely accepted. Even human psychology is coming around to seeing the benefits of animal studies that don't treat the animals purely as stimulus-response robots, especially those animals closest to us. Predictably, the fields that have longest held onto the very old human/animal dichotomy, with the accompanying belief that "evolution stops at the neck", are those concerned with humans and the furthest away from biology: the humanities (which pains me, as a former Classics major). Even folks you would not expect show occasional flashes of emotionally-motivated human exceptionalism, like the primate research team that learned a chimpanzee in Japan performed significantly better than humans on a specific memory-related task and responded by training to beat the chimp as hard as they could. Despite this, the field marches on. Many former bastions of evidence for human exceptionalism have not fared well: animals have been shown to remember things from the past, take action in the present to prepare for anticipated conditions, hold off on strong biological urges like hunger and lust until the time is right, and even perhaps metacognition, with clever experiments showing animals opting out of problems they recognize as harder to solve than the easier ones.
· My favorite in this category is the "Reverse Clever Hans" effect. You have probably heard of Clever Hans, the horse that could "count", who it turned out was just very good at spotting unconscious cues from his owner. It's a classic in psychology on the importance of careful experimental design. Well, a lot of human child/chimp comparison studies have run into the opposite problem. Human children, usually around the ages of 2-4, and chimps of various ages are asked to complete a variety of tasks and graded on how they do compared to each other. Chimps do pretty well on tool use comparisons, but human children blow away the chimps on tests of social skills. What's going on? With the tools, the experimenter basically just shows the tools to the humans/chimps and lets them mess around. But the social skills being tested are how well the subjects follow the experimenter's cues or learn from others. Is this because humans are so much better at social skills than apes? Or might it be because they are following the cues of someone from the same damn species and that the researchers are usually neutral, not well known, and do not engage in any friendly behavior with the chimps, but likely smile and encourage the human children? Where Clever Hans was given an unfair advantage by reading too much from a human, in a "Reverse Clever Hans" situation, humans compared with animals get all the benefits from reading the human and the animals do worse because they are relying on a human.
Book Review: A Clinical Introduction To Lacanian Psychoanalysis
April 26, 2022 · Original source
The idea of an ego at risk of collapse sort of reminds me of Buddhism - “desire is the root of all suffering” and “the self is an illusion” both seem like pretty Lacanian ideas. It’s interesting how far this has spread beyond either source: I think most pop psychology now just accepts that the “self” is some kind of projection or illusion, and that this probably has something to do with consumerism and whatever other modern maladies we’re supposed to be against. I guess I always just accepted this idea without really thinking about it. When I do think about it, I get kind of confused: if my entire life has been a series of desperate attempts to maintain the facade of my ego, how come I don’t feel able to stop having that facade even if I want to? How come if I sit in a dark room and think “okay, gonna stop propping up my ego right now!” nothing bad happens? If everything were to go wrong - if I were to become completely humiliated, if all my friends were to abandon me, if I lost all my material goods, if every defense mechanism were mercilessly stripped from me one after another - would something eventually happen corresponding to “my ego collapses”?
Physics is stuck in an annoying equilibrium where the Standard Model works for almost everything, and then occasionally we come across some exotic domain where it totally falls apart and we know that reality must be something deeper and weirder. I feel like psychology is the same way: you can explain almost everything with your standard scientific toolkit. Then you look at sex, and you realize you’ll need something much more complicated and worse. And since sex is maybe the strongest and most primal form of desire, if the Standard Model Of The Mind doesn’t explain sex, it probably doesn’t really explain anything else. There are probably all those weird curled-up shadow dimensions in everything, just out of sight.
Highlights From The Comments On The Academic Job Market
June 06, 2023 · Original source
I'm an odd duck in this case. I wanted to be an UG teacher back in 1974 (my mentor said, "I suspected that of you."), before the Federal money started streaming to my field, psychology. But there were no good jobs available then, so I took one at a comprehensive university that then got ambitious and shot up to R1 status remarkably quickly. So I had to get with the program and do research, and did get tenure, though I could not today, as I never got grants.
Links For February 2025
February 27, 2025 · Original source
32: Related: Psychology is doubling down on wokeness (X). And Steven Pinker resigned from (X) the American Psychological Association, accusing them of anti-Semitism.
Inline links: Psychology is doubling down on wokeness (X), resigned from (X), of anti-Semitism
Puritans4 mentions across 4 issues

Puritans is a recurring concept in the Astral Codex Ten archive, appearing 4 times across 4 issues between August 26, 2021 and August 08, 2024. The archive places it in contexts such as ""It sure is lucky that this institution, created by long-dead Puritans to teach reading and arithmetic...""; "institution, created by long-dead Puritans to teach reading and arithmetic"; "Then the later Puritans and Pietists, copying back from Counter-Reformation spirituality". It most often appears alongside Achilles, US, 4chan.

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Puritans
Mention count
4
Issue count
4
First seen
August 26, 2021
Last seen
August 08, 2024
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Highlights From The Comments On Missing School
August 26, 2021 · Original source
It sure is lucky that this institution, created by long-dead Puritans to teach reading and arithmetic, coincidentally ended up having all of these totally different benefits, any one of which would be sufficient justification for keeping it around!
Your Book Review: The Weirdest People in the World
August 11, 2023 · Original source
Here’s one thing that looks to me like a historically extended push: from the earliest Reformers onwards, the constant drive towards character education. It starts with Lutherans trying and failing to reform the country peasants by teaching them their catechism5. Then the later Puritans and Pietists, copying back from Counter-Reformation spirituality, going deeper into themselves before they try to change the world; the first children’s books, the great spiritual classics like Pilgrim’s Progress. Then the secular 18th century experimenters like Rousseau; and the first state education systems – all universally agreed that the point of education is character, not technical skills; and mostly within a broadly Christian framework.
Inline links: 5
Matt Yglesias Considered As The Nietzschean Superman
July 30, 2024 · Original source
Therefore, we can feel contempt for him. I don’t have anything better than this obvious compromise, but I’m not satisfied by it. I would like to end up with an overall negative view of Tate. And if I do a simple calculation, (virtues - vices), then it seems like if his nonmoral virtues were strong enough, they could overcome the moral vices. If Tate was a really really good kickboxer, he might still end up in the black. It seems much more intuitive to say that no amount of nonmoral virtues can make up for his moral vices. But now we’re back at the full slave moralist package again! Some “compromise”! Also, suppose Tate wasn’t a rapist, he was just some kickboxing champion who was a jerk to people online and constantly posted about he was better than them because of his Bugatti. I still want to feel contempt for him! Now we have to rate the vice of “boastfulness” so negatively that it overwhelms all possible positive virtues, which sounds like some kind of ridiculous straw man of slave morality. All these problems would go away if we gave up on unified assessments of people. Then we could classify Tate as a very good kickboxer who also happens to rape a lot of people. But if we give up on unified assessments, aren’t we giving up on the very possibility of heroes? Isn’t this just the slave moralist denial of judgment? Also, I think Nietzsche would say something something vitalism. He seemed to think there was a coherent conceptual unity between being strong, being skilled, and being some sort of unconstrained wild person who didn’t care what lesser people thought. Is there some sense in which Andrew Tate loses some genuinely valuable virtue, however small, if he becomes a normal civilized person who says please and thank you and is really respectful to everyone? Does he become less powerful, in some sense where powerfulness is good? Is he less able to achieve his destiny of being glorious? I’m genuinely unsure what Nietzsche would have thought of Tate, but it probably isn’t something as simple as “he should be nicer”.4 I’m worried this still isn’t coming off strongly enough. You can argue “master morality is about being strong and good; slave morality is just about preserving your pathetic little feelings”. But most of life is people’s pathetic little feelings. People have proven over and over again that their decisions - about what to do, what to buy, who to vote for, even what to die for - depend more on what lets them feel dignity and self-respect than on any purely material considerations. Every so often, usually on 4chan, you see an actual bully really going at it, unrestrained. Some kind of shock jock, saying “Note to unattached liberal women above 40: you are ugly hags who have lost your chance with men and all your eggs have dried up and nobody will ever value you anymore, you should either beg for some fat alcoholic guy to take you in since that’s the only man you can get, or resign yourself to being a cat lady growing old with nothing to do but dwell on your regrets and what could have been.” Outside of 4chan, there’s a sort of universal alliance against these people, which the rest of us join immediately and unconsciously. Is this the dreaded “herd” of “slave morality”? If so, long live the herd. VII. Cotton Mather Fine. Maybe we do need a Superman to sort this out. What are our options? Preliminary question: where do the Puritans fall on this dichotomy? On the one hand, they’re Christian, so they have a strong slave morality heritage. They talked a lot about humility, altruism, frugality, and self-discipline. On the other, they sure did talk about them a lot. The Puritans were convinced that virtues were real and good. They were convinced that some people had more of them than others, and that made those people better. The Puritans would have burnt you at the stake if you accused them of believing in the Promethean human spirit conquering the natural world. But they did sort of believe in it - at least enough to believe it was their moral mission to colonize a virgin continent. My goal here isn’t to explore the weird Puritan theology around who was a good person (nobody, we are all incredibly sinful, but God chooses to redeem some people through no virtue of their own, and then those people are genuinely better off and do fewer sins). Rather, I want to examine two different forms (levels?) of slave morality. In the first form, you replace the masters’ virtues with different virtues. But those virtues are still real. You can still embody them more or less well. This sort of creates a new hierarchy. The Puritans wouldn’t have respected a Bronze Age barbarian warlord. But they did respect the local minister. And the local minister was probably a smart, competent, disciplined, hard-working guy. From your respect for the local minister, you can rebuild civilization. Instead of obeying a warlord, you obey the minister, out of respect for the God and the values that he represents. In the second form, you notice that the first form is just another hierarchy of masters. You (the wretched of the earth) used to be contemptible because you were weaker and poorer than the warlord. Now you’re contemptible because you’re less virtuous and disciplined than the minister. Even if there’s no local minister, everyone’s still keeping track of how you said the word “darn” once and are therefore unsuitable for God’s kingdom. So you decide to reject not just the masterly virtues (strength, wealth, etc), but also the slavish virtues (continence, dignity, altruism) in favor of . . . no virtues? The virtue of hating other virtues, which shows that you’re enlightened to the true nature of the world where all virtues are fake? I used to have this map on my wall: It’s Progressive-era propaganda about the superiority of the American North over the South, but I find it most interesting for its list of virtues. It starts with Liberty, then moves on to Free Speech, Intelligence, Obedience To Law, Knowledge, Equal Rights, Free Schools, Contentment, Love Of Country, Philanthropy, Benevolence, Happiness, Patience, Charity, Faith, Hope, Joy, Industry, Sobriety, Morality, Justice, Virtue, Truth, Honor, Peace, Light, and Immortality. I appreciate the Progressive virtues because of how skew they are to most of the ethical systems I encounter. They’re not leftist (Love Of Country? Industry? Morality?) or rightist (Equal Rights? Free Schools?). They’re not Nietzschean master moralist (Philanthropy? Contentment? Benevolence?) or slave moralist (Industry? Knowledge? Honor?). They’re Christian-ish, but not hair-shirts-and-self-flagellation Christian or God-n-guns-megachurch Christian. They’re the kind of Christians who you can kind of tell are going to end up supporting eugenics in a few years. I think I would classify them as a first-form-slave-morality liberalism, whereas most of the liberalism you encounter these days drifted at least a little into the second form. I’m not 100% on Team Early 20th Century Progressive, but they give me hope that there are weird-yet-coherent groupings of virtues we haven’t even imagined. I feel the same way about some old Soviet posters: These are obviously left-wing, in the sense that they’re literal Communist propaganda. But to the modern eye there’s something off about them, something that makes you want to call them right-wing or even fascist. They’re bold and optimistic. Even though the commissars who commissioned them probably rejected some traditional or capitalist conception of virtue, they still firmly insist that there’s something sort of like virtue or power which is attainable and good. I think these are first-form posters, and that most modern leftism is second-form. I think if you had to group barbarian warlords, Puritans, Soviet communists, and modern leftists on a Nietzschean/geneaological/aesthetic axis, it would go: (Barbarian warlords) | (Puritans, Soviet communists) | (modern leftists) So one very weak compromise - hardly even a compromise, since it predates Nietzsche - is to try to stick with first-form slave morality, in the hopes that most of the problems come from the second. VIII. Ayn Rand “Is Ayn Rand a Nietzschean?”- the greatest thread in the history of forums, locked by a moderator after 12239 pages of heated debate. There’s a real answer here. Rand started out respecting, maybe even loving Nietzsche. She once said that: [Nietzsche’s] Thus Spake Zarathustra is my Bible. I can never commit suicide while I have it. …which maybe reveals more about her psychological situation than I expected from the answer to a “who’s your favorite philosopher” questionnaire. But later on she broke from him. It’s hard to figure out her exact position - she has a bad habit of treating anyone who disagrees with her in any tiny detail as the Antichrist, such that it’s hard to figure out whether she thinks of someone as a 99% fellow traveler or an arch-enemy. Still, there are substantial differences. Nietzsche is more chaotic - he expects the superior man to defy all external rules in favor of his own glorious destiny. But Rand is attached to rules - most of all the epistemic rules of Reason, but also the usual moral tenets like “don’t kill” and “don’t steal”. Nietzsche’s masters take the Ron Swanson approach to justifying their actions: …whereas Rand’s masters are prone to giving twenty-page-long arguments for why whatever they’re doing is the right choice according to Objectively Correct Moral Law. Rand’s approach has lots of advantages. The Nietzschean master, like Andrew Tate, is an awful guy to have around. It’s hard to fit him into a functioning civilization, except maybe an autocracy with him as autocrat. Nietzsche’s pitch is “hey excellent people, you should try to become this guy”, never “hey normal people, you should support my project of creating these guys, out of your own self-interest.” The latter wouldn’t pass the laugh test. Rand’s masters, while still probably very stressful to be around, have been tamed. They follow civilized rules of honesty and nonviolence - not, of course, because they’re too weak to defy them, but because following civilized rules is objectively the coolest thing of all. Instead of competing in battle and leaving a trail of bloody corpses, they compete in Capitalism and leave a trail of high-paying jobs and excellent consumer goods. They’re not doing to serve you - “I should serve the little guy” is slave moralist bulls**t. But, by coincidence, their excellent actions are doing you a service. They might only invent rocket ships to enact their Promethean conquest of nature and prove their own greatness. But you still get to ride in one. Rand also spares more of a thought (or at least an afterthought) for the little guy. Capitalism needs all types - even the company janitor genuinely contributes to whatever glorious accomplishments are going on, and deserves to feel good about themselves. She wants everyone to be the best, most ambitious, and most fighting-for-their-own-aesthetic/moral-vision they can be. But if that means being the company janitor, that’s fine. And if you love rockets and you consummate that love by becoming the janitor for a rocket company, the Objectively Correct Moral Law is 100% on board. I am not a Nietzsche scholar, but I think this is a more productive answer than Nietzsche has for this question. The disadvantage of Rand’s approach compared to Nietzsche’s is that it only works if you believe her proofs about why the Objectively Correct Moral Law is definitely objective and correct - most of which seem to me to be either hand-wavy or balderdash. Otherwise the whole thing breaks down - why is the most masterful thing to be a positive-sum capitalist instead of a negative-sum warlord? Rand really really wants to justify a peaceful, glorious, positive-sum society, to the exact people most capable of benefiting from defecting against it, without bringing in altruism or the common good at any point. It’s an extremely sympathetic goal. But I don’t think she makes it. Still, this is why I’m fond of her. If you really read her books - as opposed to skimming them while subvocalizing “this is that evil woman who loves selfishness” under your breath the whole time - it’s obvious that she believes, with a deep and burning belief, that good things are good. She really really wants to think that you can objectively convince people to support a peaceful, glorious, positive-sum society, without any hint of the psychologically-toxic slave morality that typified the USSR she grew up in. When people react to her books with loathing - without even a hint of fondness - I get suspicious that they’ve gotten so deep into slave morality that thy can’t recognize goodness when it hits them over the head with a sledgehammer. Elsewhere, I wrote: Edward Teach (Sadly, Porn) is famous for making up fake novels to criticize, and it is a little known fact that the "Ayn Rand" character along with all her novels are 100% his work. They operate as a diagnostic test based on his psychodynamic theory of envy. The instrument presents a picture of some exceptional people achieving great things who don't apologize for their greatness, and doesn’t explicitly ask the patient - I mean, reader - for their opinion. If the reader has no strong opinion, or says something like "Good for them, I guess," she passes the test. "I like these people and will use them as a role model" also passes. Some specific criticisms (see below) may also pass. If the reader says "Ah, people who are better than the pathetic sheep around them, just like I'm better than all the pathetic sheep around me!", she . . . still passes the test. That's not what it's testing for! You fail the test if you absolutely freak out about some combination of the Rand characters themselves and the potential existence of arrogant people who identify with the Rand characters. The secret is that it's not a screening test for the kind of people who would get featured on /r/iamverysmart. It's a screening test for the kind of people who would comment on /r/iamverysmart, ie the self-designated Tall Poppy Police, ie the people who build their ego off being the enforcers of the rule that you're not allowed to look better than anyone else. These people's basic mental stance is to hate people who seem too excellent. They don't think of it in these terms. They think of it as calling out arrogance, although if you look too closely you'll find their definition of arrogance covers anyone who seems excellent and but doesn't spend all their time apologizing and abasing themselves and denying it. The brilliance of Teach-Rand is how he-she draws this tendency to the foreground For example, why the whole "Objectivism" thing? Not because value is necessarily completely objective, but because the idea that any value might ever be even partially objective freaks out the Tall Poppy Syndrome people. Mention value at all, and they say you must be trying to secretly smuggle in the assumption that you are more valuable than other people (and therefore you are less valuable than other people, and therefore they are better than you). The same is true of Reason. Mention that Reason exists, and they'll interpret it as a claim that you, the only rational person, are claiming to always be right and infallible. But (they retort) actually nobody knows anything, and the only wise people are the people like them who humbly admit this. (how do you decide what's true without Reason? By bias-based-reasoning - "You say X, but I can imagine a way that would come from a place of believing you're better than other people, therefore, Not-X is true. You say that's a logical fallacy? That must come from a place of believing you're smarter than everyone else and the only person who can use Facts and Logic.") The Teach-Rand test is designed to catch the sort of person who, if someone says that on a right triangle a^2 + b^2 = c^2, responds with "Oh, so you're claiming to be some kind of right triangle expert who's better than the rest of us? You really need to work on that arrogance problem! Super cringe!" Any criticism of the book that doesn't come from this particular place is irrelevant to the test and doesn't count against your grade. (which is good, because the books are bad in a lot of ways. But that's fine - Rorschach blots don't also have to be great art!) Still, I don’t think she’s the superman (superwoman?) who successfully transcends the dichotomy Her philosophy is only as strong as its proofs of Objective Correctness, which I consider weak. Without those, you need some subjective motivation to glue things together - of which altruism is the most popular. But also, don’t we like altruism? When we’re bestriding the Earth like colossi, working on our glorious rocket ships to colonize the universe, isn’t part of what we’re thinking “this is going to revolutionize humankind and make everybody better off?” If you force yourself to reject that motivation, to just repeat “no no no, I’m only doing this because rockets are really big and make cool explosions”, aren’t you cutting out a part of yourself, in exactly the way Nietzschean masters are supposed to try to avoid doing? I find something very compelling about Rand. I think she goes some of the way to answering the Andrew Tate objection to master morality. But she’s a means and not an end. A real superman would have to figure out some way to reintroduce basic human kindness. IX. Matt Yglesias Yglesias’s mantra - “good things are good” - is too perfect and profound to come from anyone other than an esoteric master of Nietzschean philosophy. Good Straussians ignore the title and focus on the subtitle. Nietzsche wrote in the 1890s. There were still real nobles and emperors walking around; communists had not yet started calling capitalism “late capitalism”. Sure, his world was probably some sort of weak compromise between master and slave morality, but it was different from our weak compromise. Our weak compromise was forged through dialogue and warfare with fascism’s novel take on master morality and socialism’s novel take on slave morality. I think of Yglesias - who combines an insistence that good things are good and a proclivity for embiggenment with commitments to democracy, the welfare state, and the poorest among us - as one of its most self-conscious proponents. When I first titled this post, I didn’t know that Richard Hanania had come to the same conclusion and created this face-mash-up of Matt Yglesias and Nietzsche. The compromise goes something like: Everyone is equal before the law, before the metaphorical throne of metaphorical God, and in some poorly defined philosophical sense. This is very important. It’s our headline result. Everything else should be interpreted in light of this central fact.
Inline links: 4, https://substackcdn.com/image/fetch/$s_!qsg1!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fd81d5434-5610-41dd-878e-9de6446d91b1_913x832.png, https://substackcdn.com/image/fetch/$s_!O9yN!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Ffc156151-6861-4a76-8e2a-ba3882952e08_4096x2717.jpeg, https://substackcdn.com/image/fetch/$s_!6V8D!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F7f1f70cc-b468-4b04-b894-a8b75b3330e5_1024x683.jpeg, https://substackcdn.com/image/fetch/$s_!FF8B!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F0a1ac7aa-d19e-43e8-8462-210325b902be_810x545.png, a real answer here, https://substackcdn.com/image/fetch/$s_!OtNv!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F6ae1aaf2-6cc3-488c-b0a7-5df62eee457b_225x225.jpeg, Elsewhere, Sadly, Porn, /r/iamverysmart, https://substackcdn.com/image/fetch/$s_!MzIr!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Ff03d1a9d-5ffc-45ff-84bc-db3388915bbc_259x390.jpeg, https://substackcdn.com/image/fetch/$s_!hYvV!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fd0f9b152-da12-4525-b062-b4c14d8b8005_383x373.png
These are obviously left-wing, in the sense that they’re literal Communist propaganda. But to the modern eye there’s something off about them, something that makes you want to call them right-wing or even fascist. They’re bold and optimistic. Even though the commissars who commissioned them probably rejected some traditional or capitalist conception of virtue, they still firmly insist that there’s something sort of like virtue or power which is attainable and good. I think these are first-form posters, and that most modern leftism is second-form. I think if you had to group barbarian warlords, Puritans, Soviet communists, and modern leftists on a Nietzschean/geneaological/aesthetic axis, it would go: (Barbarian warlords) | (Puritans, Soviet communists) | (modern leftists) So one very weak compromise - hardly even a compromise, since it predates Nietzsche - is to try to stick with first-form slave morality, in the hopes that most of the problems come from the second. VIII. Ayn Rand “Is Ayn Rand a Nietzschean?”- the greatest thread in the history of forums, locked by a moderator after 12239 pages of heated debate. There’s a real answer here. Rand started out respecting, maybe even loving Nietzsche. She once said that: [Nietzsche’s] Thus Spake Zarathustra is my Bible. I can never commit suicide while I have it. …which maybe reveals more about her psychological situation than I expected from the answer to a “who’s your favorite philosopher” questionnaire. But later on she broke from him. It’s hard to figure out her exact position - she has a bad habit of treating anyone who disagrees with her in any tiny detail as the Antichrist, such that it’s hard to figure out whether she thinks of someone as a 99% fellow traveler or an arch-enemy. Still, there are substantial differences. Nietzsche is more chaotic - he expects the superior man to defy all external rules in favor of his own glorious destiny. But Rand is attached to rules - most of all the epistemic rules of Reason, but also the usual moral tenets like “don’t kill” and “don’t steal”. Nietzsche’s masters take the Ron Swanson approach to justifying their actions: …whereas Rand’s masters are prone to giving twenty-page-long arguments for why whatever they’re doing is the right choice according to Objectively Correct Moral Law. Rand’s approach has lots of advantages. The Nietzschean master, like Andrew Tate, is an awful guy to have around. It’s hard to fit him into a functioning civilization, except maybe an autocracy with him as autocrat. Nietzsche’s pitch is “hey excellent people, you should try to become this guy”, never “hey normal people, you should support my project of creating these guys, out of your own self-interest.” The latter wouldn’t pass the laugh test. Rand’s masters, while still probably very stressful to be around, have been tamed. They follow civilized rules of honesty and nonviolence - not, of course, because they’re too weak to defy them, but because following civilized rules is objectively the coolest thing of all. Instead of competing in battle and leaving a trail of bloody corpses, they compete in Capitalism and leave a trail of high-paying jobs and excellent consumer goods. They’re not doing to serve you - “I should serve the little guy” is slave moralist bulls**t. But, by coincidence, their excellent actions are doing you a service. They might only invent rocket ships to enact their Promethean conquest of nature and prove their own greatness. But you still get to ride in one. Rand also spares more of a thought (or at least an afterthought) for the little guy. Capitalism needs all types - even the company janitor genuinely contributes to whatever glorious accomplishments are going on, and deserves to feel good about themselves. She wants everyone to be the best, most ambitious, and most fighting-for-their-own-aesthetic/moral-vision they can be. But if that means being the company janitor, that’s fine. And if you love rockets and you consummate that love by becoming the janitor for a rocket company, the Objectively Correct Moral Law is 100% on board. I am not a Nietzsche scholar, but I think this is a more productive answer than Nietzsche has for this question. The disadvantage of Rand’s approach compared to Nietzsche’s is that it only works if you believe her proofs about why the Objectively Correct Moral Law is definitely objective and correct - most of which seem to me to be either hand-wavy or balderdash. Otherwise the whole thing breaks down - why is the most masterful thing to be a positive-sum capitalist instead of a negative-sum warlord? Rand really really wants to justify a peaceful, glorious, positive-sum society, to the exact people most capable of benefiting from defecting against it, without bringing in altruism or the common good at any point. It’s an extremely sympathetic goal. But I don’t think she makes it. Still, this is why I’m fond of her. If you really read her books - as opposed to skimming them while subvocalizing “this is that evil woman who loves selfishness” under your breath the whole time - it’s obvious that she believes, with a deep and burning belief, that good things are good. She really really wants to think that you can objectively convince people to support a peaceful, glorious, positive-sum society, without any hint of the psychologically-toxic slave morality that typified the USSR she grew up in. When people react to her books with loathing - without even a hint of fondness - I get suspicious that they’ve gotten so deep into slave morality that thy can’t recognize goodness when it hits them over the head with a sledgehammer. Elsewhere, I wrote: Edward Teach (Sadly, Porn) is famous for making up fake novels to criticize, and it is a little known fact that the "Ayn Rand" character along with all her novels are 100% his work. They operate as a diagnostic test based on his psychodynamic theory of envy. The instrument presents a picture of some exceptional people achieving great things who don't apologize for their greatness, and doesn’t explicitly ask the patient - I mean, reader - for their opinion. If the reader has no strong opinion, or says something like "Good for them, I guess," she passes the test. "I like these people and will use them as a role model" also passes. Some specific criticisms (see below) may also pass. If the reader says "Ah, people who are better than the pathetic sheep around them, just like I'm better than all the pathetic sheep around me!", she . . . still passes the test. That's not what it's testing for! You fail the test if you absolutely freak out about some combination of the Rand characters themselves and the potential existence of arrogant people who identify with the Rand characters. The secret is that it's not a screening test for the kind of people who would get featured on /r/iamverysmart. It's a screening test for the kind of people who would comment on /r/iamverysmart, ie the self-designated Tall Poppy Police, ie the people who build their ego off being the enforcers of the rule that you're not allowed to look better than anyone else. These people's basic mental stance is to hate people who seem too excellent. They don't think of it in these terms. They think of it as calling out arrogance, although if you look too closely you'll find their definition of arrogance covers anyone who seems excellent and but doesn't spend all their time apologizing and abasing themselves and denying it. The brilliance of Teach-Rand is how he-she draws this tendency to the foreground For example, why the whole "Objectivism" thing? Not because value is necessarily completely objective, but because the idea that any value might ever be even partially objective freaks out the Tall Poppy Syndrome people. Mention value at all, and they say you must be trying to secretly smuggle in the assumption that you are more valuable than other people (and therefore you are less valuable than other people, and therefore they are better than you). The same is true of Reason. Mention that Reason exists, and they'll interpret it as a claim that you, the only rational person, are claiming to always be right and infallible. But (they retort) actually nobody knows anything, and the only wise people are the people like them who humbly admit this. (how do you decide what's true without Reason? By bias-based-reasoning - "You say X, but I can imagine a way that would come from a place of believing you're better than other people, therefore, Not-X is true. You say that's a logical fallacy? That must come from a place of believing you're smarter than everyone else and the only person who can use Facts and Logic.") The Teach-Rand test is designed to catch the sort of person who, if someone says that on a right triangle a^2 + b^2 = c^2, responds with "Oh, so you're claiming to be some kind of right triangle expert who's better than the rest of us? You really need to work on that arrogance problem! Super cringe!" Any criticism of the book that doesn't come from this particular place is irrelevant to the test and doesn't count against your grade. (which is good, because the books are bad in a lot of ways. But that's fine - Rorschach blots don't also have to be great art!) Still, I don’t think she’s the superman (superwoman?) who successfully transcends the dichotomy Her philosophy is only as strong as its proofs of Objective Correctness, which I consider weak. Without those, you need some subjective motivation to glue things together - of which altruism is the most popular. But also, don’t we like altruism? When we’re bestriding the Earth like colossi, working on our glorious rocket ships to colonize the universe, isn’t part of what we’re thinking “this is going to revolutionize humankind and make everybody better off?” If you force yourself to reject that motivation, to just repeat “no no no, I’m only doing this because rockets are really big and make cool explosions”, aren’t you cutting out a part of yourself, in exactly the way Nietzschean masters are supposed to try to avoid doing? I find something very compelling about Rand. I think she goes some of the way to answering the Andrew Tate objection to master morality. But she’s a means and not an end. A real superman would have to figure out some way to reintroduce basic human kindness. IX. Matt Yglesias Yglesias’s mantra - “good things are good” - is too perfect and profound to come from anyone other than an esoteric master of Nietzschean philosophy. Good Straussians ignore the title and focus on the subtitle. Nietzsche wrote in the 1890s. There were still real nobles and emperors walking around; communists had not yet started calling capitalism “late capitalism”. Sure, his world was probably some sort of weak compromise between master and slave morality, but it was different from our weak compromise. Our weak compromise was forged through dialogue and warfare with fascism’s novel take on master morality and socialism’s novel take on slave morality. I think of Yglesias - who combines an insistence that good things are good and a proclivity for embiggenment with commitments to democracy, the welfare state, and the poorest among us - as one of its most self-conscious proponents. When I first titled this post, I didn’t know that Richard Hanania had come to the same conclusion and created this face-mash-up of Matt Yglesias and Nietzsche. The compromise goes something like: Everyone is equal before the law, before the metaphorical throne of metaphorical God, and in some poorly defined philosophical sense. This is very important. It’s our headline result. Everything else should be interpreted in light of this central fact.
Inline links: a real answer here, https://substackcdn.com/image/fetch/$s_!OtNv!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F6ae1aaf2-6cc3-488c-b0a7-5df62eee457b_225x225.jpeg, Elsewhere, Sadly, Porn, /r/iamverysmart, https://substackcdn.com/image/fetch/$s_!MzIr!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Ff03d1a9d-5ffc-45ff-84bc-db3388915bbc_259x390.jpeg, https://substackcdn.com/image/fetch/$s_!hYvV!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fd0f9b152-da12-4525-b062-b4c14d8b8005_383x373.png
Highlights From The Comments On Nietzsche
August 08, 2024 · Original source
Nietzsche has good psychological insight, but I think that he offers a distorted perspective for analyzing social morality. What you see as "hybrid" moral systems from a Nietzschean POV (Puritans, early Soviets, post civil war progressives, Yglesias ... ) are pretty typical in their merger of embiggening and ensmalling virtues. My guess is that only sick, disordered societies are dominated by either slave or master moralities (obviously, most societies have have had both b/c it's hard to be a slave w/o a master or vice versa).
Palestinians3 mentions across 3 issues

Palestinians is a recurring concept in the Astral Codex Ten archive, appearing 3 times across 3 issues between March 30, 2022 and December 10, 2024. The archive places it in contexts such as "But since Palestinians don’t have all the normal rights in Israel, they are"; "And end with Palestinians Struck dead by falling aid"; "It contains two million Palestinians, separated from Israel". It most often appears alongside Belgium, Israel, US.

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Palestinians
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3
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March 30, 2022
Last seen
December 10, 2024
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  • Belgium 2 shared issues
  • Israel 2 shared issues
  • US 2 shared issues
  • ACT 1 shared issues
  • AI 1 shared issues
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Who Gets Self-Determination?
March 30, 2022 · Original source
As best I can tell, international law on this question centers around a UN-backed covenant which says that “all peoples have the right to self-determination”. So are Texans/Kurds/Scots/Palestinians a “people”? International law makes no effort to answer this question. Presumably Volodymyr Zelenskyy thinks Ukrainians count as a people, and Vladmir Putin isn’t so sure.
Inline links: covenant
Other sources have defined “a people” based on exclusion from existing political structures. So since Texans have all the normal rights in the US, they’re not a separate people. But since Palestinians don’t have all the normal rights in Israel, they are. But this suggests that if Putin invaded eg Finland, and then granted the Finns whatever the normal rights are in Russia, Finns would stop being a people.
Verses On Five People Being Killed By A Falling Package Of Foreign Aid
March 14, 2024 · Original source
The best laid plans of mice and men Are oft unwisely laid And end with Palestinians Struck dead by falling aid
And so we sighed, and multiplied And after that, we prayed For souls of Palestinians Struck dead by falling aid.
Highlights From The Comments On Prison
December 10, 2024 · Original source
People call Gaza an “open-air prison”, and the comparison makes sense. It contains two million Palestinians, separated from Israel by a wall, barbed wire, and military guards. Security isn’t infallible (see 10/7), but the breach required a near-state level of resources (including funding/arms/supplies from Israel’s enemies) plus a rare catastrophic blunder on Israel’s part - and all it did was get a few thousand Gazans over the wall for a few hours.
Pax Americana3 mentions across 3 issues

Pax Americana is a recurring concept in the Astral Codex Ten archive, appearing 3 times across 3 issues between March 08, 2022 and May 19, 2023. The archive places it in contexts such as "If the Pax Americana is dead, we need to try something different"; "Nuclear risk is neglected by the public because of Pax Americana since the collapse of the USSR"; "ed by the public because of Pax Americana since the collapse of the USSR". It most often appears alongside EU, Iran, New York.

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Pax Americana
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Ukraine Thoughts And Links
March 08, 2022 · Original source
I don’t think Ukraine proves that “history has restarted” or “the Pax Americana was a paper tiger” or anything of the sort. These kinds of local conflicts were always allowed. Just ask an Iraqi. Or a Chechen, or an Afghan, or a Syrian, or a Bosnian, or a Crimean, or a Tigrayan or go back and ask the Iraqi a second time.
2: If the Pax Americana is dead, we need to try something different; but if it’s still alive, we should stick with what works.
The Pax Americana playbook for international norm violations is: the US slaps sanctions on the offender. The EU expresses “concern”. The UN proposes a resolution condemning it, which gets vetoed by whichever Security Council member is most complicit. And the CIA secretly gives Stinger missiles to everyone involved.
Your Book Review: Public Choice Theory And The Illusion Of Grand Strategy
June 24, 2022 · Original source
Nuclear risk is neglected by the public because of Pax Americana since the collapse of the USSR, and is not discussed as often in EA as it’s thought to be relatively well-funded and mainstream, but in fact major donors like the MacArthur Foundation have been withdrawing funding. As Joan Rohling details in an 80,000 Hours podcast there is much to be done, especially when Ukraine gave up their nuclear arsenal in 1994 in exchange for Russia’s promise to never threaten or use military force against them. A worthwhile adjacent cause area might be de-escalation of public outcry to reduce x-risk from nuclear war beyond just regular anti-proliferation efforts — even a Russian specialist from the RAND Corporation is surprised by how much public outrage is driving policy: Even just the pace of the sanctions: we went to 11 out of 10 in like two days — farther than many expected we’d ever get in short order. And I think the same is true about these military assistance initiatives. We’re just trying to do something because there’s a public demand for action. So that’s what worries me, that the sort of public outrage that’s being channeled in Western democracies through political systems could result in decisions that prove ultimately unwise. Despite how odd it is that some wars are “legal” while others aren’t, we should be glad UNSC exists as much as everyone laughs at how useless the rest of the UN is. All is fair in love and war, but international norms is all that stands between us and nuclear annihilation. It is hard to emphasise just how delusional it is for the public to fixate on no-fly zones — I, like Scott, am surprised we’re still capable of jingoism. 80,000 Hours has updated their top career recommendations to include China specialist to improve China-Western coordination on global catastrophic risk, which seems more important after reading how irrational and captured the American foreign policy apparatus is. As Hanania writes, “great power competition” is an anachronism. If Ukraine is the first war warped by hyperreality, it won’t be the last. Now that US foreign policy elites have driven Putin into the arms of China, let’s hope IR specialists can imbibe the public choice model instead of antagonising yet another nuclear rival. Public Choice Theory and the Illusion of Grand Strategy is an important work because it raises the sanity waterline, which at the least should make us stop killing millions for no reason, and at the most should make the human race more knowledgeable of how to prevent total extinction from nuclear armageddon. Pax Americana is dead, but a multipolar world will be more humane. Endnotes In the fiscal year 2018, the top five government contractors were all weapons manufacturers, with Lockheed Martin in first place at $40.6 billion. The Department of Defence spent $358 billion on contracting, ten times higher than second place Department of Energy. Collective action problems that stop a bunch of smaller companies from effectively influencing policy are no hindrance for companies like Lockheed Martin.
Inline links: Pax Americana, MacArthur Foundation, details, gave up, surprised, Scott, jingoism, China specialist, captured, writes, the sanity waterline, a multipolar world will be more humane
Pax Americana had been so strong that even American ice-cream companies have foriegn policy priorities — Ben & Jerry's thinks NATO should chill a little over Ukraine.
Inline links: Ben & Jerry's thinks NATO should chill a little over Ukraine
The Question Of Separatism
May 19, 2023 · Original source
The third transaction of decline is heavy trade between advanced and backward cities, especially on credit. Selling a helicopter factory to the Shah of Iran is fine if the Shah pays for it with oil, but if Iran buys the factory on a loan and fails to pay it back (as poor regions often do, and as Iran did due to the revolution), then that’s also wealth that is drained away from cities. Nor does this kind of trade help backward economies develop. You can’t replace imports from an economy that’s much more advanced than you are: the gulf is too great. Let’s take a moment here to appreciate how Jacobs casually destroys ideas so many of us hold dear. Trade between rich and poor countries seems obviously good. Military production isn’t exactly popular, but most people agree we need it for peace. The world would be far less safe without the military-backed Pax Americana. And welfare programs! Who wouldn’t want to send help to the poor, the unproductive, the retired? It seems inhumane to say that rich countries shouldn’t redistribute their wealth to alleviate poverty. Unfortunately, that’s exactly why these things are transactions of decline. They seem like obviously good ideas at first. But then they spiral out of control. The more military production you invest in, the poorer you become, and the more you need military production to hold the empire together. The more welfare you provide, the poorer you become, and the more you need welfare to alleviate that poverty. Jacobs’s book, published in 1984, includes this sentence: “As this is written, French students are rioting because of curtailments of subsidies.” Well. As this review is written, in March 2023, French people are rioting because the government is pushing the age of retirement from 62 to 64. Once you start relying on transactions of decline, you can’t ever stop. The Forbidden Solution All empires eventually collapse. This is not what we would expect if empires were a good economic arrangement. If they only ever got wealthier and wealthier, they wouldn’t disintegrate into various separatist factions or end in foreign conquest. The first empire to form would have slowly absorbed everything else, and we would all be living good lives under the enlightened rule of the Sumerians or whatever. But that doesn’t happen, because empires always milk their own cities until they become poor. Modern nation-states do the same. They accumulate stress by trying to hold themselves together, and then, one day, the stress is released all at once. Wars and revolutions galore. Most countries are born that way, like new stars formed in the aftermath of a supernova. Peaceful separatism offers an alternative, Jacobs says — but only a theoretical one. Jacobs shows us a glimpse of a world in which secessions would be “a normal, untraumatic accompaniment of economic development itself.” Regions would separate when they feel the need to, before decline has set in. “In this utopian fantasy,” she writes, “young sovereignties splitting off from the parent nation would be told, in effect, ‘Good luck on your independence! Now do try your very best to generate [or maintain, as the case may be] a creative city and its region and we’ll all be better off.’” Can you imagine Canada saying this to Quebec? Or England to Scotland? Or China to Tibet and Taiwan? Yeah, me neither. That’s why it’s only theoretical and utopian. Jacobs knows very well that nations will never accept separatism as an option. And though the term “nationalist” has fallen out of fashion, almost all of us still think very much in terms of nations. Even when separatism does seem grudgingly acceptable, I’d say that’s usually either because it’s an instance of decolonization (colonial empires are decidedly out of fashion) or for cultural, nationalistic reasons. Quebecois, Scottish, or Catalan separatists say that they belong to nations that are culturally distinct from Canada, the United Kingdom, or Spain. And they love their smaller nation just as much as others love the larger one. If any of these separatists got their way, we can be sure that the new nation of Quebec, Scotland, or Catalonia would then oppose further separatism in the strongest terms. When the American South seceded from the Union in 1861, the reaction wasn’t “good luck!” even though the Union was itself the result of a secession from Great Britain. To separate for economic reasons seems forbidden. Unthinkable. For one thing, it would be selfish. If Catalonia left, the poor regions of Spain, which benefit from welfare financed in part by Barcelona, would suffer, which is obviously unacceptable to Spain. For another, it’s not guaranteed to work. Small countries and city-states can still adopt dumb economic policies. It can seem intolerably risky to go your own way, unless your region is already rich, in which case see the selfishness point above. Widespread separatism also seems worse for solving large-scale coordination problems, like environmental issues, nuclear proliferation (and, perhaps, AI), or war. I suspect that Jacobs would agree with Nassim Taleb’s antifragility framing: it’s better to be in a constant state of mild disorder than to have apparent stability that hides stressors and ends in violent conflict. But that idea is not intuitive. Most of us would pick apparent stability over mild disorder. I also suspect — and this is my personal take — that we dread the additional complexity of having numerous small countries. We look at a map of medieval Germany, like this one… … and we think, thank goodness that Germany is unified now. So much easier to think about! Can you imagine if the Our World in Data charts had to show separate lines for the Electorate of Saxony, the Prince-Bishopric of Augsburg, the Duchy of Brunswick-Lüneburg, and about 1,800 other semi-sovereign states? Can you imagine traveling around if each of them had its own currency? (Fun fact: the List of states in the Holy Roman Empire Wikipedia page doesn’t contain such a list. Instead it points to no less than 28 sub-lists.) Jacobs stops shy of asking, in either book, the question that seems to be the logical continuation of her reasoning: should everything be a city-state? Should we encourage separatism until each inhabited place in the world is either a city or a city region with its own currency? We can hazard a guess as to what her answer would be. She would probably say that there’s no need to upend everything right this moment. Just adopt an attitude of political openness and experimentation. Don’t try to hold together entities that don’t work that well. When separatist sentiment arises somewhere, you can argue it’s a bad idea, but don’t fight it out of emotion such as fear for your nation’s integrity. Eventually, things will settle — the regions that want to be city-states will be, and those that prefer to be united with others, for cultural or economic reasons, will stay that way. Unity has good PR and some genuine advantages, so there will still be plenty of it. But maybe Jane Jacobs never asks this question because she knows it’s irrelevant. We just can’t help fighting for our big countries and supranational unions (like the EU), and too bad if they enter long periods of stagflation until they violently collapse. This might be the right time to mention that her last book, published in 2004, is called Dark Age Ahead. IV. Something to Dislike For Everyone Jane Jacobs’s most famous book is The Death and Life of Great American Cities. She is recognized as perhaps the most influential thinker in urbanism. She is credited with saving Greenwich Village and SoHo in New York City, and helping cancel the Spadina Expressway in Toronto. To this day people organize “Jane’s Walks” as a living memorial to her impact on cities. But Jane Jacobs herself thought that her greatest intellectual contribution was not in city planning, but in economics. She thought that import replacement was her most important discovery, since it explained how wealth expands better than existing macroeconomic theories. She wrote multiple books that were explicitly about economics and was about to write another when she died, Uncovering the Economy. I am not an economist, so I might not be qualified to make a judgment on this matter, but: it seems to me that there’s a discrepancy here. Jacobs is widely seen as a great intellectual, but her economic ideas don’t quite seem mainstream. I’d never heard of import replacement before reading her book. Why not? The null hypothesis is that economists have examined her ideas and simply rejected them. There were some critical academic reviews of Cities and the Wealth of Nations when it came out, and more recently Tyler Cowen expressed his own mild skepticism. Some of the criticism involves the lack of quantitative data in her work, and her failure to think about issues of scale. The most obvious target, of course, is her city obsession: yes, cities are important, but they’re not the only economic phenomenon that matters, some would say. Perhaps Jacobs has overplayed her hand. But there are other possible explanations for the discrepancy. One is that she was a woman and had no credentials, which made it difficult for (mostly male) professionals to take her seriously. We know this was true at the beginning of her career at least. It seems possible that even after she managed to establish herself as an original urban thinker, economists had trouble accepting that she could, with her lack of any college degree, come up with new insights in their field. I doubt that’s really true today, though. We do take Jacobs seriously, and still read all of her books, which is more than we could say about most economists. Instead, I propose that the discrepancy comes from a darker place: in laboring to be comprehensive about cities and economics, she reached conclusions that most people don’t want to be true. No matter your politics, there’ll be something for you to dislike in Jacobs’s work. For example, it’s pretty clear that she didn’t think the European Union was a good idea, so she probably would have supported Brexit. Brexiters might rejoice, except that a lot of them are British nationalists who certainly don’t want Scotland to leave the UK, whereas Jacobs would agree with that. Which would be great news to Scottish independentists — except that if a new separatist movement arose within Scotland, she’d also support that. Jacobs’s ideas and grassroots activism in favor of small-scale, organic urban planning have come to be seen as left-wing — yet her criticism of national welfare programs wouldn’t make her out of place among hardcore right-wingers. Unless those right-wingers were military hawks, in which case they’d find no solace in reading Jacobs on military transactions of decline. Writing during the Cold War, Jacobs criticized the Soviet Union for its incredible centralization of decision-making in Moscow. She rightfully predicted its collapse, making her an ideological ally of the capitalist West, right? Not so, since the United States is also, according to her, too centralized and in the early stages of decay. “Today the Soviet Union and the United States each predicts and anticipates the economic decline of the other,” she writes. “Neither will be disappointed.” Whether she was correct about the US is left as an exercise to the reader. In any case, she did foresee, using her theory on cities, the decline of Japan. This must have been bold in the 1980s at the peak of the Japanese economic miracle, when there was a widespread trope that Japan would soon take over the world. Yet she was right: in 1991, Japan entered its “lost decade,” which soon became two lost decades, and then three. To be fair, she predicted the decline of all large-ish countries, so I wouldn’t mark her as a superforecaster or anything. Still, this puts in perspective the more recent trope that China is going to take over the world. No country, no ideology is safe from Jacobs’s prophecies. Smaller ideologies aren’t spared, either. Effective altruism would probably seem totally mistaken to her, since at its core it promotes an inorganic, top-down transfer of wealth from prosperous cities to poor areas. Progress studies people think that technological innovation will solve economic stagnation, but she would point out how labor-saving equipment so often causes damage when it is introduced to regions that don’t benefit from the other city forces, like the Scottish Highlands or many of her other examples in Colombia, India, or the American South. (This point would deserve an essay of its own, but reading Jacobs has made me a bit more worried about the “AI will take our jobs” thing. It’s clear that new jobs will appear, but when the technology city force from the San Francisco Bay Area reaches distant places with poor economies, which it will very soon thanks to the internet, the effects might not be very pleasant to see.) Overall, the political ideology that might fit Jacobs the best might be… libertarianism? She’s not a big fan of large governments who make big top-down decisions, clearly. Yet I don’t get the feeling that this association fits all that well either. Jacobs doesn’t seem to be anti-government if the government is at the city level. I doubt she would have liked the kind of hyperfragmented world depicted in Snow Crash by Neal Stephenson. I also doubt she’d be impressed by cryptocurrency-backed “cloud cities” or fantasies of charter cities, none of which she would see as real cities in the sense of concentrated pockets of people who start replacing what they import with local production. Jane Jacobs, in sum, was an archetypal accidental moderate. She took one idea very seriously — the idea that cities are fundamental — and explored its ramifications without caring in the slightest if it led to the “wrong” opinions, as her friends in 1980 Toronto must have thought when she wrote about Quebec. I don’t know if she went too far; I’m sure someone more qualified than I am can find flaws in that core idea or any of her other observations. But to me she sounds convincing, and her consistency is frankly admirable. So, to end this review on a more review-y note, go read Jane Jacobs. Her books are a delight, with their elegant arguments and masterfully told anecdotes. Her predictions often take an air of doom, but she is also an optimist who offers constructive ways forward. She sets an example for all of us who care about getting the details right, no matter the credentialed experts, the current political climate, or the great theories of the past. Image credits Cities and the Wealth of Nations book cover: from Amazon.
Inline links: https://substackcdn.com/image/fetch/$s_!Fh6a!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F3e3f5028-3af5-457d-8038-db2c3a65eb3a_1599x1022.png, https://substackcdn.com/image/fetch/$s_!sPn6!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fd25ceff6-f68e-4163-becf-613204a9be35_1600x1297.png, List of states in the Holy Roman Empire, https://substackcdn.com/image/fetch/$s_!gyMq!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fdc388f24-009c-42ee-adca-9d5c50faaa66_932x190.png, academic, reviews, expressed, Japan would soon take over the world, fantasies, of, charter, cities, accidental moderate, https://substackcdn.com/image/fetch/$s_!r8Rb!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F60621c76-b34b-4e10-b272-394480443e1b_1600x1066.png, Amazon
Pharisees3 mentions across 3 issues

Pharisees is a recurring concept in the Astral Codex Ten archive, appearing 3 times across 3 issues between October 10, 2022 and August 08, 2024. The archive places it in contexts such as "grey deity of the Pharisees"; "The Bible says that the Pharisees asked Jesus if the Jews should pay taxes to Rome"; "Pharisees and Sadducees hold themselves as superior because they're better at following the social rules of the time". It most often appears alongside Jesus, Bible, Christianity.

Article page
Pharisees
Mention count
3
Issue count
3
First seen
October 10, 2022
Last seen
August 08, 2024
Outbound links
Issue trail
Related pages
Source context
Highlights From The Comments On Columbus Day
October 10, 2022 · Original source
But there was something that did not end. There had arisen in that hour of history, defiant above the democratic tumult of the Councils of the Church, Athanasius against the world. We may pause upon the point at issue; because it is relevant to the whole of this religious history, and the modern world seems to miss the whole point of it. We might put it this way. If there is one question which the enlightened and liberal have the habit of deriding and holding up as a dreadful example of barren dogma and senseless sectarian strife, it is this Athanasian question of the Co-Eternity of the Divine Son. On the other hand, if there is one thing that the same liberals always offer us as a piece of pure and simple Christianity, untroubled by doctrinal disputes, it is the single sentence, 'God is Love.' Yet the two statements are almost identical; at least one is very nearly nonsense without the other. The barren dogma is only the logical way of stating the beautiful sentiment. For if there be a being without beginning, existing before all things, was He loving when there was nothing to be loved? If through that unthinkable eternity He is lonely, what is the meaning of saying He is love? The only justification of such a mystery is the mystical conception that in His own nature there was something analogous to self-expression; something of what begets and beholds what it has begotten. Without some such idea, it is really illogical to complicate the ultimate essence of deity with an idea like love. If the moderns really want a simple religion of love, they must look for it in the Athanasian Creed. The truth is that the trumpet of true Christianity, the challenge of the charities and simplicities of Bethlehem or Christmas Day never rang out more arrestingly and unmistakably than in the defiance of Athanasius to the cold compromise of the Arians. It was emphatically he who really was fighting for a God of Love against a God of colourless and remote cosmic control; the God of the stoics and the agnostics. It was emphatically he who was fighting for the Holy Child against the grey deity of the Pharisees and the Sadducees. He was fighting for that very balance of beautiful interdependence and intimacy, in the very Trinity of the Divine Nature, that draws our hearts to the Trinity of the Holy Family. His dogma, if the phrase be not misunderstood, turns even God into a Holy Family.
Even More Bay Area House Party
January 04, 2023 · Original source
“You’re missing the point of the parable,” says the crypto bro. “The Bible says that the Pharisees asked Jesus if the Jews should pay taxes to Rome. Jesus held up a coin with Caesar’s picture on it, and said to render unto Caesar what is Caesar’s. He was saying that if you have government-controlled fiat money, then you’ll never be able to control how you use it. But just as the denarius depicted Caesar, Bitcoin is a depiction of God - an immaterial, formless, omnipresent entity. What you do with your Bitcoin is between you and God and nobody else.”
Highlights From The Comments On Nietzsche
August 08, 2024 · Original source
The Gospels do feature some stories that could be seen as pro-slave morality, where Pharisees and Sadducees hold themselves as superior because they're better at following the social rules of the time. But Jesus' criticism of them isn't that trying to find rules on how to be good and follow them better is bad - it's that they've become so fixated on the literal rules that they've lost sight of the actual purpose of the rules: loving and caring for the people around them.
PhD3 mentions across 3 issues

PhD is a recurring concept in the Astral Codex Ten archive, appearing 3 times across 3 issues between June 28, 2024 and September 02, 2025. The archive places it in contexts such as "it’s monitored by PhD’s"; "first LGBT person to get a PhD in the study of ancient Assyria"; "some of them already have 'PhD level intelligence'". It most often appears alongside 2023 special, Aashish Reddy, ACX grant winners.

Article page
PhD
Mention count
3
Issue count
3
First seen
June 28, 2024
Last seen
September 02, 2025
Outbound links
Issue trail
Related pages
Source context
Your Book Review: Dominion
June 28, 2024 · Original source
Scully asks him to comment on the frankly disturbing living conditions, only to have Godwin reject the premise. He thinks that the pigs like where they live. He says it’s good for them. They eat all they want, there are no predators, it’s warm, it’s monitored by PhD’s, and there’s nothing he would do differently. He also gives a curious concession to the fact that the pigs are not actually unfeeling robots:
Open Thread 378
April 21, 2025 · Original source
Five, maybe ten percent of applicants are some kind of special snowflake whose father was murdered when they were five years old. As he lay there bleeding out, he said “Daughter, my whole life, I dreamed of being the first LGBT person to get a PhD in the study of ancient Assyria. Now that dream has been taken from me. With my dying breath, I give you my trowel and hand-painted figurine of Tiglath-Pileser III, in the hopes that one day you will succeed where I failed”. […]
What Is Man, That Thou Art Mindful Of Him?
September 02, 2025 · Original source
No direct inline source block was recovered for this mention.
polyamory3 mentions across 3 issues

polyamory is a recurring concept in the Astral Codex Ten archive, appearing 3 times across 3 issues between February 07, 2024 and November 01, 2024. The archive places it in contexts such as "The Atlantic ’s recent invective against polyamory"; "polyamory was mostly female-driven"; "nobody in this story was assigned to the polyamory group". It most often appears alongside Europe, /r/BadMTGCombos, 2017 SSC survey.

Article page
polyamory
Mention count
3
Issue count
3
First seen
February 07, 2024
Last seen
November 01, 2024
Outbound links
Issue trail
Related pages
Source context
You Don't Hate Polyamory, You Hate People Who Write Books
February 07, 2024 · Original source
Yesterday I criticized The Atlantic’s recent invective against polyamory (subscriber-only post, sorry). Today I want to zoom away from the specific bad arguments and examine the overall form of the article.
Inline links: I criticized
The overall form was: “I read a memoir about polyamory, everyone involved seemed awful and unhappy, and now I hate polyamorous people.” This is a common pattern. Sometimes, if someone’s very careful, they read three or four books about polyamory. Everyone in all the books is awful and unhappy. Then they conclude they hate polyamorous people.
The actual best-known polyamory advice book is More Than Two, by Franklin Veaux and Eve Rickert. A few years after it was written, Eve and three of Franklin’s other partners accused him of abuse, which he vehemently denied and turned back on her. Every so often I check to see how things are going, and one of them has come up with some new volley against the other.
Highlights From The Comments On Polyamory
February 21, 2024 · Original source
[Original posts: Contra The Atlantic On Polyamory (subscriber only), You Don’t Hate Polyamory, You Hate People Who Write Books]
Inline links: Contra The Atlantic On Polyamory (subscriber only), You Don’t Hate Polyamory, You Hate People Who Write Books
Micah Zolu writes:
Inline links: writes
Aella’s survey includes data from 430,000 people! The average social class is somewhere between lower-middle and middle, so this isn’t just capturing elites, and should be able to address concerns that polyamory only works as a “luxury belief”.
Inline links: includes data from
Links For November 2024
November 01, 2024 · Original source
…whose grantee David Baker recently won a Nobel Prize for his research on synthetic proteins. Potential applications include new drugs, vaccines, and materials. 25: Rich Kid Memes And The Online Culture Of The One Percent. Rich people who want to signal group membership to other rich people online can’t boast about how rich they are; that would be gauche. Instead, they’ve settled on the solution of making fun of rich people in hyperspecific language that proves familiarity with the culture. 26: Tap Water Sommelier: Vladimir Putin has two sons, ages 5 and 9. They are kept in luxurious but total isolation from the outside world and raised by flunkies who are too scared to punish/restrain them in any way. Also some discussion of an unexpected historical analogue. 27: Experiment from Colombia: replacing experienced teachers with less-experience but higher-scoring-on-tests teachers significantly decreased student performance. Got to admit I was expecting the opposite of this, I’d seen US data saying that experience didn’t matter and teacher intelligence did. Looking over this more, I find lots of studies on both sides and will go back to agnosticism on this question until someone I trust investigates further. 28: Large scale-formal Intellectual Turing Test finds that people can imitate partisans effectively; ie nobody on either side can tell the difference between a Democrat arguing for Democrat values vs. a Republican-pretending-to-be-a-Democrat arguing for Democrat values (and vice versa). This study used a 100 word essay on why you supported your party (you can see if you can do better here), but past attempts with different structures (religion, vegetarianism, polyamory) have shown broadly the same results. The researchers try to put this in the context of various studies showing that people do misunderstand their opponents (eg think they’re more extreme, underestimate the level of common ground), but it seems like intellectual Turing Tests aren’t a good way to measure or tease out this misunderstanding. 29: Congratulations to Substacker WoolyAI for doing the impossible and providing a genuinely novel and interesting (to me) take on pickup artistry: 30: Did you know: if you Google “cool websites”, our subreddit (r/slatestarcodex) is the first result. 31: Moshe Koppel, who works at the intersection of computer science and Talmud, is writing a series of posts (presumably) based off of my Every Bay Area House Party, titled Jerusalem Area House Party (it’s multiple part, you have to go to the main Substack page to find the others). I won’t necessarily link everyone who riffs off one of my posts - but honestly I probably will if you also have a Wikipedia page that describes you as working on computational Talmudology. 32: David Roman says it’s a myth that Arabic scholars rescued and preserved the works of the great classical authors. 33: Medications often decrease “secondary endpoints” (eg stroke, heart attack), but the holy grail of pharma studies is proving that a certain drug decreases all-cause mortality. This is much harder (not all heart attacks kill people, and people die from lots of other things), but is the strongest possible endorsement for the drug (without it, you might worry that it only prevented non-fatal heart attacks, or that it killed as many people through side effects as it saves through heart attack prevention). Even great medications that we’re confident in can’t always clear this bar. But a new JAMA article adds another member to this select club: Adderall decreases all-cause mortality in ADHD, probably because it prevents drug addiction, car accidents, and impulsive actions. 34: Before the Gulf War got in the way, Saddam Hussein was building some crazy mosques: 35: Italy bans surrogacy - quite strictly, too, Italians aren’t even allowed to go abroad and do it. I am so sorry for all the Italians who will never get to be mothers and fathers because their government hates progress. You might hope that, whatever the other disadvantages of anti-immigrant parties, at least they’re incentivized to let natives have children, but looks like they can’t even get that one right. Starting to wonder whether the trains even run on time. 36: Elsewhere in “Italy sucks” news - did you know Italy’s tax code effectively bans startups? Companies are taxed before making any money, based on how many assets they have. If they have lots of assets but aren’t making money (eg because they’re still doing research / in stealth) then tax officials get confused and hostile and run increasingly punitive audits. Related: size of the European tech sector. It’s the red line on this chart; if you can’t see a red line at your screen resolution, then you’ve learned something important about the the EU tech sector. 37: Seen on @cremieuxrecuel’s twitter (preliminary, needs replication): Jews may have gone from 65-29 Democrat/Republican in 2020 to 58-40 this election. 38: Extelligence has a post responding to my critique of the cultural Christianity argument (among, uh, many other things), but I don’t really think it connects. I’m not telling atheists they can’t go to church/synagogue if it makes them feel happy and fulfilled - I’ve done this myself sometimes. My post was meant to argue against the claim that, for pragmatic reasons, atheists should support the Christianization of society as a defense against Islam or postmodernism or some other philosophical enemy. 39: Related: Extelligence is finally going for their Trust Assembly project/idea/startup for online consensus-based truth-seeking (I think something like a cross between Community Notes and Wikipedia, but as a browser extension, and for everything). He’s looking for potential developers/testers/users. 40: Jiankui He is the Chinese geneticist who made history with the first germline gene editing in humans (resulting in three babies supposedly immune to AIDS, although nobody has tested this). China sentenced him to three years in prison for unauthorized experimentation, but now he’s out of jail, has an English-language Twitter account, has a new lab, wants to work on Alzheimers, and seems pretty based (although not infinitely based): 41: Anthropic has a new version of their AI Claude which can use your computer. You give it permission, put it on a virtual desktop, and ask it to do things for you (eg “please find and download a picture of a cat” or “please research these ten things and put them in a text file”.) It moves your cursor, browses the Internet, and creates and saves files. People keep saying they’ll care about AI “when it operates autonomously” or “when it becomes an agent”. But this is a trivial barrier, and one which Computer Use Claude has arguably already passed. So far this feature is limited to developers (though anyone with computer knowledge can sign up for it) but I expect it to be the near future of consumer AI, to get better quickly, and to shade gradually into the “autonomous” “agentic” AI that you all think will require a paradigm shift. 42: Claim (from the IDF): Hamas faked polls showing that most Palestinians supported the October 7 attack; the real numbers are 31% in favor, 64% against. 43: Otto von Bismarck wanted to trick France into declaring war on Germany. In order to provoke the French, he sent the Ems Dispatch, a statement describing recent diplomatic events in a way that sounded maximally offensive. The French were so offended that “crowds” in Paris demanded war, and the Franco-Prussian War was declared soon afterwards. The part of this that I find most interesting is the text of the dispatch itself, which read: After the news of the renunciation of the Prince von Hohenzollern had been communicated to the Imperial French government by the Royal Spanish government, the French Ambassador in Ems made a further demand on His Majesty the King that he should authorize him to telegraph to Paris that His Majesty the King undertook for all time never again to give his assent should the Hohenzollerns once more take up their candidature. His Majesty the King thereupon refused to receive the Ambassador again and had the latter informed by the Adjutant of the day that His Majesty had no further communication to make to the Ambassador. I’m fascinated by the idea that only 150 years ago, it was obvious that if someone sent you this statement, you had to declare war or abandon all honor. If I read it carefully, I can sort of parse out that it sounds like the Prussians are unhappy, but that’s the most emotion I gather from it. Anyway, the Franco-Prussian War led to World War I which led to World War II - so if you don’t like 50 million people dying and the total devastation of Europe, blame this statement about ambassadors. 44: The first use of artificial insemination in humans: The first recorded case of artificial insemination by donor didn’t occur until 1884, when Dr. William Pancoast decided to treat a couple’s infertility by secretly inseminating the woman with sperm obtained from a medical student. The insemination happened while the patient was under anesthesia and Dr. Pancoast did not tell her what had occurred. She gave birth to a baby boy nine months later, but it was several years before the doctor finally confessed to her husband what he had done. Neither man ever informed the mother. It was 25 years later the result of this case was published. Dr. Pancoast was roundly condemned for his actions, but it did open the door for consensual sperm donor insemination. 45: ClearerThinking administers several personality tests to the same people to learn more about their comparative accuracy. I am most interested in their finding that tests with “factors” (eg the Big Five, where you rate people on a numeric scale) are inherently more accurate than those with “types” (eg Myers-Briggs, where you assign someone a specific category) and that, adjusting for this, Big Five is no more predictive than the Enneagram: 46: In 2022, I wrote Whither Tartaria, where I asked why ornate classical styles switched to more austere modernist styles around 1900 - 1950 in a variety of different arts (painting, architecture, literature, poetry, etc). I proposed seven theories, but was unsure which if any were true. Since then, Samuel Hughes of Works In Progress has been investigating. In May, he wrote a well-researched article showing that it wasn’t just increasing cost, because ornate classical architecture now costs less than ever. Now in a new article he demolishes a different theory - it’s not just decreasing cost (and subsequent lack of ability to signal wealth) - because costs didn’t decrease in several other arts, and the change was led by artists with rich people as reluctant followers. He concludes: Modernism may well be a status game of some kind; it may well signal taste more than it signals wealth; and this latter feature may be one of the things that distinguishes it from older artistic styles. But the mechanism by which this change came about must be different to the one Alexander describes. 47: Sort of kind of related - When Hamilton Lost Its Snob Appeal. The musical Hamilton was briefly an artistic/cultural phenomenon, but tastemakers eventually switched to making fun of it. Why? Rob Henderson says it happened after ticket prices came down and the common people could enjoy it. I disagree: everyone I knew who was into Hamilton got into it from the free online soundtrack long before they’d seen the show; I think this is more likely the usual fad cycle where anybody who’s too into yesterday’s fad is behind the curve and therefore uncool. 48: Related: Why are people such jerks to public intellectuals? And more. I agree this is a great mystery. 49: Some prominent Substack psychiatrists doing a video Q&A, submit your questions here. 50: Naomi Kanakia: The Literacy Delusion had a number of explanations for why reading books seemed to be so much worse for human beings (in terms of emotional wellness and productivity) than other forms of narrative entertainment, but its main theory was the integration hypothesis. That the stream of words in a book trained the human brain into a habit of self-consciousness, that reading books forced human beings to think of themselves as a stream of text, processed through time, making a coherent argument of some sort. And that this overall flattening effect forced readers to ignore aspects of their personality or their situation that were not otherwise in line with the overarching story they'd created about themselves. Basically, reading books causes repression and neurosis. The Literacy Delusion argued that, yes, human beings are storytelling machines, but that a stream of written text is a particular kind of story—a story that is particularly flat, particularly devoid of conflicting or harmonizing information—and that this flatness creates a peculiar effect on the human brain. 51: Last month, I linked Sasha Gusev’s No, Intelligence Is Not Like Height and asked people who disagreed to share their arguments; they sure did. First, several people pointed me to a new preprint, Family-GWAS Reveals Effects Of Environment And Mating On Genetic Associations, which finds that one of the main papers Gusev cited to make his case, Howe 2022, made a mistake - imputing sibling genotypes using a process designed for non-sibling genotypes - and that once that mistake is corrected, the finding disappears and intelligence and height appear similar. Second, Joseph Bronski has a more specific post where he responds to Gusev’s points one by one. He accuses Gusev of “[making] up his own chart to remove the error bars [from the originals], to obscure the fact that the study found no evidence for this in IQ”, and says that the cases where he didn’t do that are just “population stratification and range restriction”. Third, Noah Carl at Aporia, instead of writing a direct response like Bronski, argues that the usual method of attacking twin studies is obsolete; not only have the most-debated assumptions behind twin studies been thoroughly validated, but there are now other lines of evidence besides twin studies which confirm high IQ heritability. Fourth, Leonardo Parro (not framed as a response to Gusev) goes into more depth about one of those ways, a “pedigree-based analysis” demonstrating heritability of 54 - 69%, ie no “missing heritability” compared to twin studies. He summarizes this as the effect of “rare variants” compared to the usual SNPs - ie if you only look at the most common genes that are easiest to find, you get “missing heritability” compared to twin studies, but if you widen your search to rare genes that are hard to find, you don’t. 52: Extremely related: Heliospect is a startup promising polygenic selection for IQ and other traits; they were trying to stay in stealth mode but The Guardian spied on them and nonconsensually revealed their existence. The discussion on the r/ssc subreddit centered on their claim that (given enough embryos to choose from) they could increase a baby’s expected IQ by 6 points (I’ve also heard 7.5). Sasha Gusev had previously argued that current technology maxed out at 3.5 and future technology would max out at 6, so a claim of 6 - 7.5 is pretty extreme; Gwern, who wrote the pioneering analysis of this technology, was also skeptical. But Heliospect says they’ve got better predictors than academia that use the rare variants everyone else misses; after talking to the company, Gwern retracted his objections and says he finds their claim “pretty plausible”. Local ACX commenter geneticist Gene Smith also redid some calculations, changed his mind, and says “probably pretty realistic”. I find this interesting not just because of the polygenic selection angle, but because if Heliospect is right then their predictor is able to predict more genetic IQ than the “missing heritability” people believe exists, and it should be able to put this argument to bed once and for all. 53: This month in censorship: X/Twitter banned journalist Ken Klippenstein for sharing the Trump campaign’s dossier on JD Vance. Twitter’s side of the story is that the dossier was probably originally stolen by Iranian agents and they don’t want to support that kind of thing by letting people signal-boost the illicitly obtained goods; you can read Klippenstein’s side here. He appears to be unbanned now.
Inline links: won a Nobel Prize, Rich Kid Memes And The Online Culture Of The One Percent, Tap Water Sommelier, Experiment from Colombia, experience didn’t matter, teacher intelligence did, Large scale-formal Intellectual Turing Test, you can see if you can do better here, religion, vegetarianism, polyamory, WoolyAI, https://substackcdn.com/image/fetch/$s_!4FRI!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F558ad67a-bfca-469e-abd8-2edc7c8b888a_590x916.png, if you Google “cool websites”, r/slatestarcodex, who works at the intersection of computer science and Talmud, Jerusalem Area House Party, says it’s a myth, Adderall decreases all-cause mortality in ADHD, some crazy mosques, https://substackcdn.com/image/fetch/$s_!2W0c!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fc2be0549-aa2b-411d-b6a6-da50c34f7f86_1000x572.jpeg, Italy bans surrogacy, Italy’s tax code effectively bans startups?, Related, https://substackcdn.com/image/fetch/$s_!T3h-!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F08b011b3-ef20-42e5-91b2-33946b8ca7b6_1761x1355.jpeg, @cremieuxrecuel, responding to my critique of the cultural Christianity argument, My post, is finally going for, Trust Assembly, has an English-language Twitter account, has a new lab, wants to work on Alzheimers, and seems pretty based, not infinitely based, https://substackcdn.com/image/fetch/$s_!fY_K!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F6b3b61c8-6c48-4eb7-9608-426b738ab9c8_592x111.png, which can use your computer, Claim, Ems Dispatch, The first use of artificial insemination in humans, administers several personality tests to the same people, https://substackcdn.com/image/fetch/$s_!epEc!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F47c474c6-d68a-41e4-954e-d24cd00ec040_740x388.webp, Whither Tartaria, a well-researched article showing, in a new article he demolishes a different theory, When Hamilton Lost Its Snob Appeal, Why are people such jerks to public intellectuals?, more, Some prominent Substack psychiatrists doing a video Q&A, submit your questions here, Naomi Kanakia, No, Intelligence Is Not Like Height, Family-GWAS Reveals Effects Of Environment And Mating On Genetic Associations, Howe 2022, a more specific post where he responds to Gusev’s points one by one, argues that the usual method of attacking twin studies is obsolete, goes into more depth about one of those ways, The Guardian spied on them and nonconsensually revealed their existence, discussion, previously argued, the pioneering analysis of this technology, Gwern retracted his objections, says, polygenic selection, banned journalist Ken Klippenstein, you can read Klippenstein’s side here., appears to be unbanned now
Portuguese3 mentions across 3 issues

Portuguese is a recurring concept in the Astral Codex Ten archive, appearing 3 times across 3 issues between June 29, 2022 and July 19, 2024. The archive places it in contexts such as "It looks into all hospitalizations that occurred in Portuguese public hospitals"; "that’s what “Portuguese” is"; "No Pirahã spoke Portuguese". It most often appears alongside Chicago, Spanish, Wikipedia.

Article page
Portuguese
Mention count
3
Issue count
3
First seen
June 29, 2022
Last seen
July 19, 2024
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Highlights From The Comments On San Fransicko
June 29, 2022 · Original source
As somebody somewhat familiar with the Portuguese situation, and who was born next door to Portugal and has lived in the neighborhood for a long time, let me clarify that Portugal is NOT a very conservative country, not even when it comes to drug use. In fact, it's so not conservative that the usual party switcheroo between conservatives and progressives there literally involves the "social-democratic party" running against the "socialist party" since the early 1970s. In fact, the only actual conservative who was ever president of Portugal in living memory was murdered by state security; they didn't even bother to cover the crime very much, and then the whole country has sort of ignored the matter for decades, as one of those things that sometimes happen https://en.wikipedia.org/wiki/Francisco_de_S%C3%A1_Carneiro. Regarding the specific issue of drug use in Portugal: we should mention this study https://pubmed.ncbi.nlm.nih.gov/31808250/, and put it in whatever context. It looks into all hospitalizations that occurred in Portuguese public hospitals from 2000 to 2015, and finds that the number of hospitalizations with a primary diagnosis of psychotic disorders and schizophrenia associated with cannabis use rose 29.4 times during the study period, from 20 to 588 hospitalizations yearly (2000 and 2015, respectively) with a total of 3,233 hospitalizations.
Inline links: https://en.wikipedia.org/wiki/Francisco_de_S%C3%A1_Carneiro, https://pubmed.ncbi.nlm.nih.gov/31808250/
Skills Plateau Because Of Decay And Interference
August 18, 2022 · Original source
Is there some way to exploit the interference hypothesis to remember things better? Suppose you were teaching a friend Spanish, and she was struggling to learn more than 20 words per day. Could you ask her to learn a second language, but secretly it’s just more Spanish words, and at the end you tell her she was learning extra Spanish all along? Has the conspiracy already gotten there before me, and that’s what “Portuguese” is?
Your Book Review: How Language Began
July 19, 2024 · Original source
Everett interviewing some Pirahã people. (source) Everett did eventually learn their language, and it’s worth taking a step back to appreciate just how hard that task was. No Pirahã spoke Portuguese, apart from some isolated phrases they used for bartering. They didn’t speak any other language at all—just Pirahã. How do you learn another group’s language when you have no languages in common? The technical term is monolingual fieldwork. But this is just a fancy label for some combination of pointing at things, listening, crude imitation, and obsessively transcribing whatever you hear. For years. It doesn’t help that the Pirahã language seems genuinely hard to learn in a few different senses. First, it is probably conventionally difficult for Westerners to learn since it is a tonal language (two tones: high and low) with a small number of phonemes (building block sounds) and a few unusual sounds3. Second, there is no written language. Third, the language has a variety of ‘channels of discourse’, or ways of talking specialized for one or another cultural context. One of these is ‘whistle speech’; Pirahãs can communicate purely in whistles. This feature appears to be extremely useful during hunting trips: (Don’t Sleep, There Are Snakes, Ch. 11, pg. 187-188) My first intense contact with whistle speech came one day when the Pirahãs had given me permission to go hunting with them. After we’d been walking for about an hour, they decided that they weren’t seeing any game because I, with my clunking canteens and machete and congenital clumsiness, was making too much noise. “You stay here and we will be back for you later.” Xaikáibaí said gently but firmly. … As I tried to make the best of my solitary confinement, I heard the men whistling to one another. They were saying, “I’ll go over there; you go that way,” and other such hunting talk. But clearly they were communicating. It was fascinating because it sounded so different from anything I had heard before. The whistle carried long and clear in the jungle. I could immediately see the importance and usefulness of this channel, which I guessed would also be much less likely to scare away game than the lower frequencies of the men’s normal voices. Fourth, important aspects of the language reflect core tenets of Pirahã culture in ways that one might not a priori expect. Everett writes extensively about the ‘immediacy of experience principle’ of Pirahã culture, which he summarizes as the idea that: (Don’t Sleep, There Are Snakes, Ch. 7, pg. 132) Declarative Pirahã utterances contain only assertions related directly to the moment of speech, either experienced by the speaker or witnessed by someone alive during the lifetime of the speaker. One way the language reflects this is that the speaker must specify how they know something by affixing an appropriate suffix to verbs: (Don’t Sleep, There Are Snakes, Ch. 12, pg. 196) Perhaps the most interesting suffixes, however (though these are not unique to Pirahã), are what linguists call evidentials, elements that represent the speaker’s evaluation of his or her knowledge of what he or she is saying. There are three of these in Pirahã: hearsay, observation, and deduction. To see what these do, let’s use an English example. If I ask you, “Did Joe go fishing?” you could answer, “Yes, at least I heard that he did,” or “Yes, I know because I saw him leave,” or “Yes, at least I suppose he did because his boat is gone.” The difference between English and Pirahã is that what English does with a sentence, Pirahã does with a verbal suffix. Everett also convincingly links this cultural principle to the lack of Pirahã number words and creation myths. On the latter topic, Everett recalls the following exchange: (Don’t Sleep, There Are Snakes, Ch. 7, pg. 134) I sat with Kóhoi once and he asked me, after hearing about my god, “What else does your god do?” And I answered, “Well, he made the stars, and he made the earth.” Then I asked, “What do the Pirahãs say?” He answered, “Well, the Pirahãs say that these things were not made.” And all of this is to say nothing of the manifold perils of the jungle: malaria, typhoid fever, dysentery, dangerous snakes, insects, morally gray river traders, and periodic downpours. If Indiana Jones braved these conditions for years, we would consider his stories rousing adventures. Everett did this while also learning one of the most unusual languages in the world. People on the bank of the Maici river. (source) By the way, he did eventually sort of achieve his goal of translating the Bible. Armed with a solid knowledge of Pirahã, he was able to translate the New Testament’s Gospel of Mark. Since the Pirahã have no written language, he provided them with a recorded version, but did not get the reaction he expected: (Don’t Sleep, There Are Snakes, Ch. 17, pg. 267-268) When we returned to the village, I recorded Mark’s gospel in my own voice for the Pirahãs to listen to. I then brought in a wind-up tape recorder to play the recording, and I taught the Pirahãs how to use it, which, surprisingly enough, some of the children did. Keren and I left the village and returned a few weeks later. The people were still listening to the gospel, with children cranking the recorder. I was initially quite excited about this, until it became clear that the only part of the book that they paid attention to was the beheading of John the Baptist. “Wow, they cut off his head. Play that again!” One reaction to hearing the gospel caught Everett even more off-guard: (Don’t Sleep, There Are Snakes, Ch. 17, pg. 269) "The women are afraid of Jesus. We do not want him." "Why not?" I asked, wondering what had triggered this declaration. "Because last night he came to our village and tried to have sex with our women. He chased them around the village, trying to stick his large penis into them." Kaaxaóoi proceeded to show me with his two hands held far apart how long Jesus's penis was—a good three feet. But the Pirahã had an even more serious objection to Jesus: (Don’t Sleep, There Are Snakes, Ch. 17, pg. 265-266) Part of the difficulty of my task began to become clear to me. I communicated more or less correctly to the Pirahãs about my Christian beliefs. The men listening to me understood that there was a man named Hisó, Jesus, and that he wanted others to do what he told them. "The Pirahã men then asked, "Hey Dan, what does Jesus look like? Is he dark like us or light like you?" I said, "Well, I have never actually seen him. He lived a long time ago. But I do have his words." "Well, Dan, how do you have his words if you have never heard him or seen him?" They then made it clear that if I had not actually seen this guy (and not in any metaphorical sense, but literally), they weren't interested in any stories I had to tell about him. Period. This is because, as I now knew, the Pirahãs believe only what they see. Sometimes they also believe in things that someone else has told them, so long as that person has personally witnessed what he or she is reporting. In the end, Everett never converted a single Pirahã. But he did even worse than converting zero people—he lost his own faith after coming to believe that the Pirahã had a good point. After keeping this to himself for many years, he revealed his loss of faith to his family, which led to a divorce and his children breaking contact with him for a number of years afterward. But Everett losing his faith in the God of Abraham was only the beginning. Most importantly for us, he also lost his faith in the God of Linguistics—Noam Chomsky. III. THE WAR In 2005, Everett’s paper “Cultural constraints on grammar and cognition in Pirahã: Another look at the design features of human language” was published in the journal Cultural Anthropology. An outsider might expect an article like this, which made a technical observation about the apparent lack of a property called ‘recursion’ in the Pirahã language, to receive an ‘oh, neat’ sort of response. Languages can be pretty different from one another, after all. Mandarin lacks plurals. Spanish sentences can omit an explicit subject. This is one of those kinds of things. But the article ignited a firestorm of controversy that follows Everett to this day. Praise for Everett and his work on recursion in Pirahã: He became a pure charlatan, although he used to be a good descriptive linguist. That is why, as far as I know, all the serious linguists who work on Brazilian languages ignore him. Noam Chomsky, MIT professor and linguist
Inline links: source, monolingual fieldwork, 3, number words, https://substackcdn.com/image/fetch/$s_!yx-R!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F77975f2c-ef0f-47d7-9ed9-f22bbe04f78b_1024x768.jpeg, source, Cultural constraints on grammar and cognition in Pirahã: Another look at the design features of human language
what one means by the statement “All natural human languages have recursion.” Everett generally takes recursion to refer to the following property of many natural languages: one can construct sentences or phrases from other sentences and phrases. For example: “The cat died.” -> “Alice said that [the cat died].” -> “Bob said that [Alice said that [the cat died.]]” In the above example, we can in principle generate infinitely many new sentences by writing “Z said X,” where X is the previous sentence and Z is some name. For clarity’s sake, one should probably distinguish between different ways to generate new sentences or phrases from old ones; Pullum mentions a few in the context of assessing Everett’s Pirahã recursion claims: Everett reports that there are no signs of no multiple coordination (It takes [skill, nerve, initiative, and courage]), complex determiners ([[[my] son’s] wife’s] family), stacked modifiers (a [nice, [cosy, [inexpensive [little cottage]]]]), or—most significant of all—reiterable clause embedding (I thought [ you already knew [that she was here ] ]). These are the primary constructions that in English permit sentences of any arbitrary finite length to be constructed, yielding the familiar argument that the set of all definable grammatical sentences in English is infinite. Regardless of the details, a generic prediction should be that there is no longest sentence in a language whose grammar is recursive. This doesn’t mean that one can say an arbitrarily long sentence in real life4. Rather, one can say that, given a member of some large set of sentences, one can always extend it. Everett takes the claim “All natural human languages have recursion.” to mean that, if there exists a natural human language without recursion, the claim is false. Or, slightly more subtly, if there exists a language which uses recursion so minimally that linguists have a hard time determining whether a corpus of linguistic data falsifies it or not, sentence-level recursion is probably not a bedrock principle of human languages. I found the following anecdote from a 2012 paper of Everett’s enlightening: Pirahã speakers reject constructed examples with recursion, as I discovered in my translation of the gospel of Mark into the language (during my days as a missionary). The Bible is full of recursive examples, such as the following, from Mark 1:3: ‘(John the Baptist) was a voice of one calling in the desert…’ I initially translated this as: ‘John, the man that put people in the water in order to clean them for God, that lived in a place like a beach with no trees and that yelled for people to obey God’. The Pirahãs rejected every attempt until I translated this as: ‘John cleaned people in the river. He lived in another jungle. The jungle was like a beach. It had no trees. He yelled to people. You want God!’ The non-recursive structure was accepted readily and elicited all sorts of questions. I subsequently realized looking through Pirahã texts that there were no clear examples involving either recursion or even embedding. Attempts to construct recursive sentences or phrases, such as ‘several big round barrels', were ultimately rejected by the Pirahãs (although initially they accepted them to be polite to me, a standard fieldwork problem that Jeanette Sakel and I discuss). He does explicitly claim (in the aforementioned paper and elsewhere) that Pirahã probably has no longest sentence, which is about the most generic anti-recursion statement one can make. Chomsky and linguists working in his tradition sometimes write in a way consistent with Everett’s conception of recursion, but sometimes don’t. For example, consider this random 2016 blogpost I found by a linguist in training: For generative linguistics the recursive function is Merge, which combines two words or phrases to form a larger structure which can then be the input for further iterations of Merge. Any expression larger than two words, then, requires recursion, regardless of whether there is embedding in that expression. For instance the noun phrase “My favourite book” requires two iterations of Merge, (Merge(favourite, book)= [Favourite book], Merge(my, [favourite book])= [my [favourite book]]) and therefore is an instance of recursion without embedding. To be clear, this usage of ‘recursion’ seems consistent with how many other Chomskyan linguists have used the term. And with all due respect to these researchers, I find this notion of recursion completely insane, because it would imply (i) any language with more than one word in its sentences has recursion, and that (ii) all sentences are necessarily constructed recursively. The first implication means that “All natural human languages have recursion.” reduces to the vacuously true claim that “All languages allow more than one word in their sentences.”5 The second idea is more interesting, because it relates to how the brain constructs sentences, but as far as I can tell this claim cannot be tested using purely observational linguistic data. One would have to do some kind of experiment to check the order in which subjects mentally construct sentences, and ideally make brain activity measurements of some sort. Aside from sometimes involving a strange notion of recursion, another feature of the Chomskyan response to Everett relates to the distinction we discussed earlier between so-called E-languages and I-languages. Consider the following exchange from a 2012 interview with Chomsky: NS: But there are critics such as Daniel Everett, who says the language of the Amazonian people he worked with seems to challenge important aspects of universal grammar. Chomsky: It can't be true. These people are genetically identical to all other humans with regard to language. They can learn Portuguese perfectly easily, just as Portuguese children do. So they have the same universal grammar the rest of us have. What Everett claims is that the resources of the language do not permit the use of the principles of universal grammar. That's conceivable. You could imagine a language exactly like English except it doesn't have connectives like "and" that allow you to make longer expressions. An infant learning truncated English would have no idea about this: they would just pick it up as they would standard English. At some point, the child would discover the resources are so limited you can't say very much, but that doesn't say anything about universal grammar, or about language acquisition. Chomsky makes claims like this elsewhere too. The argument is that, even if there were a language without a recursive grammar, this is not inconsistent with his theory, since his theory is not about E-languages like English or Spanish or Pirahã. His theory only makes claims about I-languages, or equivalently about our innate language capabilities. But this is kind of a dumb rhetorical move. Either the theory makes predictions about real languages or it doesn’t. The statement that some languages in the world are arguably recursive is not a prediction; it’s an observation, and we didn’t need the theory to make it. What does it mean for the grammar of thought languages to be recursive? How do we test this? Can we test it by doing experiments involving real linguistic data, or not? If not, are we even still talking about language? To this day, as one might expect, not everyone agrees with Everett that (i) Pirahã lacks a recursive hierarchical grammar, and that (ii) such a discovery would have any bearing at all on the truth or falsity of Chomskyan universal grammar. Given that languages can be pretty weird, among other reasons, I am inclined to side with Everett here. But where does that leave us? We do not just want to throw bombs and tell everyone their theories are wrong. Does Everett have an alternative to the Chomskyan account of what language is and where it came from? Yes, and it turns out he’s been thinking about this for a long time. How Language Began is his 2017 offering in this direction. IV. THE BOOK So what is language, anyway? Everett writes: (How Language Began, Ch. 1, pg. 15) Language is the interaction of meaning (semantics), conditions on usage (pragmatics), the physical properties of its inventory of sounds (phonetics), a grammar (syntax, or sentence structure), phonology (sound structure), morphology (word structure), discourse conversational organizational principles, information, and gestures. Language is a gestalt—the whole is greater than the sum of its parts. That is to say, the whole is not understood merely by examining individual components. Okay, so far, so good. To the uninitiated, it looks like Everett is just listing all of the different things that are involved in language; so what? The point is that language is more than just grammar. He goes on to say this explicitly: (How Language Began, Ch. 1, pg. 16) Grammar is a tremendous aid to language and also helps in thinking. But it really is at best only a small part of any language, and its importance varies from one language to another. There are tongues that have very little grammar and others in which it is extremely complex. His paradigmatic examples here are Pirahã and Riau Indonesian, which appears to lack a hierarchical grammar, and which moreover apparently lacks a clear noun/verb distinction. You might ask: what does that even mean? I’m not 100% sure, since the linked Gil chapter appears formidable, but Wikipedia gives a pretty good example in the right direction: For example, the phrase Ayam makan (lit. 'chicken eat') can mean, in context, anything from 'the chicken is eating', to 'I ate some chicken', 'the chicken that is eating' and 'when we were eating chicken' Is “chicken” the subject of the sentence, the object of the sentence, or something else? Well, it depends on the context. What’s the purpose of language? Communication: (How Language Began, Introduction, pg. 5) Indeed, language changes lives. It builds society, expresses our highest aspirations, our basest thoughts, our emotions and our philosophies of life. But all language is ultimately at the service of human interaction. Other components of language—things like grammar and stories—are secondary to conversation. Did language emerge suddenly, as it does in Chomsky’s proposal, or gradually? Very gradually: (How Language Began, Introduction, pg. 7-8) There is a wide and deep linguistic chasm between humans and all other species. … More likely, the gap was formed by baby steps, by homeopathic changes spurred by culture. Yes, human languages are dramatically different from the communication systems of other animals, but the cognitive and cultural steps to get beyond the ‘language threshold’ were smaller than many seem to think. The evidence shows that there was no ‘sudden leap’ to the uniquely human features of language, but that our predecessor species in the genus Homo and earlier, perhaps among the australopithecines, slowly but surely progressed until humans achieved language. This slow march taken by early hominins resulted eventually in a yawning evolutionary chasm between human language and other animal communication. So far, we have a bit of a nothingburger. Language is for communication, and probably—like everything else!—emerged gradually over a long period of time. While these points are interesting as a contrast to Chomsky, they are not that surprising in and of themselves. But Everett’s work goes beyond taking the time to bolster common sense ideas on language origins. Two points he discusses at length are worth briefly exploring here. First, he offers a much more specific account of the emergence of language than Chomsky does, and draws on a mix of evidence from paleoanthropology, evolutionary biology, linguistics, and more. Second, he pretty firmly takes the Anti-Chomsky view on whether language is innate: (Preface, pg. xv) … I deny here that language is an instinct of any kind, as I also deny that it is innate, or inborn. These two points are not unrelated. Everett’s core idea is that language should properly be thought of as an invention rather than an innate human capability. You might ask: who invented it? Who shaped it? Lots of people, collaboratively, over a long time. In a word, culture. As Everett notes in the preface, “Language is the handmaiden of culture.” In any case, let’s discuss these points one at a time. First: the origins of language. There are a number of questions one might want to answer about how language began: In what order did different language-related concepts and components emerge?
Inline links: Pullum, 4, 2012 paper, blogpost, 5, 2012 interview, Riau Indonesian, lack a hierarchical grammar, lacks a clear noun/verb distinction
predictive processing3 mentions across 3 issues

predictive processing is a recurring concept in the Astral Codex Ten archive, appearing 3 times across 3 issues between January 21, 2021 and July 16, 2024. The archive places it in contexts such as "the predictive processing community is starting to really chip away at the question of why psychotherapies work"; "Link to Predictive Processing"; "my introspection about my information processing makes more sense since I learned about predictive processing". It most often appears alongside Eliezer Yudkowsky, fMRI, Neuralink.

Mention count
3
Issue count
3
First seen
January 21, 2021
Last seen
July 16, 2024
Outbound links
Issue trail
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Source context
Still Alive
January 21, 2021 · Original source
That's taken up most of my time over the past six months. Going back to blog posts like this is a strange feeling. I wondered if I'd enjoy the break. I didn't particularly; it felt at least as much like trying to resist an addiction as it did resting from a difficult task. There's so much left to say! I never got the chance to tell you whether the SSC Survey found birth order effects to be biologically or socially mediated! And the predictive processing community is starting to really chip away at the question of why psychotherapies work - I need to explain this to someone else before I can be sure I understand it! I only discovered taxometrics a few months ago and I haven't talked your ears off about it yet - that will change! I made predictions about Trump - now that he's come and gone I need to grade them publicly so you can raise or lower your opinion of me as appropriate! And there's the book review contest! We are absolutely going to do the book review contest!
Your Book Review: Are We Smart Enough To Know How Smart Animals Are?
April 22, 2021 · Original source
Besides the core insight about the evolved nature of cognition and lots of examples of what that looks like, I also had a few other takeaways about how to do science, the difficulties of sharing discoveries across disciplines, the continuity of neural anatomy, what we can learn from less closely-related brains, and what implications it might have for predictive processing theory.
Besides the delightful stories about animals surprising researchers with how clever they can be (they really are a lot of fun), I found the biggest takeaway to be that cognition is not in a special class, and it shows the same evidence of conservation and continuity that you find everywhere else in evolved beings. Just as all vertebrate skeletons show a clear family resemblance, so too do vertebrate brains and nervous systems. The same underlying efficiency of evolution explains both the continuity and the variation of cognition across vertebrates: if something works, it will be kept around, twisted, changed, and put to new uses (to paraphrase Gibson, "the [environment] finds its own uses for things"). On the other hand, anything that is not helping a species' fitness will find itself on the wrong side of Darwin's balance sheet. This means that you can expect to see great variation in what kinds of cognitive abilities between species, but when you find species with common capacities and common ancestry, they're likely using the same neural lego blocks to do it (and if they're far enough apart, they probably convergently evolved based on similar selective pressures). III. Other Takeaways: How to Do Science, Continuity, Comparison, and Predictive Processing Besides the core insight about the evolved nature of cognition and lots of examples of what that looks like, I also had a few other takeaways about how to do science, the difficulties of sharing discoveries across disciplines, the continuity of neural anatomy, what we can learn from less closely-related brains, and what implications it might have for predictive processing theory.
Birds and cephalopods are especially interesting for understanding cognition and intelligence precisely because they are smart with different hardware. Bird brains still make use of the familiar vertebrate architecture, but the optimization pressures of flight have caused them to have much lighter brains with more neurons per volume. So crows and parrots can be spooky smart despite having brain to body mass ratios that don't look so hot on first blush. Cephalopods are even weirder and harder to understand. They have a lot of their nervous system spread throughout their body, including a separate ganglion for each sucker, so they might have a very different method of cognition. This difference is what makes them simultaneously potentially very valuable for exploring the full scope of cognition in the natural world, but also makes it hard to even come up with good experiments to figure out what's going on inside their rubbery, color-changing non-skulls. Link to Predictive Processing Okay, so the book doesn't actually talk about predictive processing as such, but since it was about cognition, I couldn't help but think about it. Full disclosure, almosteverything I know about Predictive Processing I learned on Slate Star Codex, so take this with a grain of salt. Given that predictive processing purports to describe what is happening at a really low level, if correct, it almost certainly is how other vertebrate cognition works. This might open up new avenues for experiment and observation that aren't open with humans (no, this isn't a call for vivisection or anything, just building on what has been described above about animals having widely varying cognition that can be tested in different ways). Perhaps even more interesting would be to try to figure out if predictive processing explains the cognition of non-vertebrates like octopodes. I don't really have much further insight on this, but this sounds like yet another place where the fields of (human) psychology/neuroscience and animal cognition could usefully inform each other.
Inline links: almost, everything, know
Consciousness As Recursive Reflections
July 16, 2024 · Original source
It should be impossible for a shared oscillation to have qualia according to one subject, but none according to the other. But honestly, what makes this explanation of qualia persuasive to myself is as subjective as they are. Like my introspection about my information processing makes more sense since I learned about predictive processing, so my introspection about my conscious experiences makes more sense since I understand them this way. For example, while I learn to perform a task it is quite conscious, but once it becomes routine, I can be unsure whether I have just done it. This makes perfect sense now: in accordance with Hebbian learning, the learning process requires repeated synchronous firing, i.e. oscillations, i.e. capacity for conscious phenomena. But the synaptic shortcuts this creates necessarily reduce the bandwidth required for the task, obviating large oscillations with their conscious phenomena.
Inline links: predictive processing, Hebbian learning
progesterone3 mentions across 3 issues

progesterone is a recurring concept in the Astral Codex Ten archive, appearing 3 times across 3 issues between March 08, 2022 and March 16, 2022. The archive places it in contexts such as "Allopregnanolone is a naturally-occuring metabolite of the female hormone progesterone"; "a natural metabolite of the female hormone progesterone"; "We've been giving progesterone for like 4 decades at the compounding pharmacy". It most often appears alongside allopregnanolone, Zulresso, FDA.

Article page
progesterone
Mention count
3
Issue count
3
First seen
March 08, 2022
Last seen
March 16, 2022
Outbound links
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Zounds! It's Zulresso and Zuranolone!
March 08, 2022 · Original source
Allopregnanolone is a naturally-occuring metabolite of the female hormone progesterone. In 1981, scientists found it was present in unusually high concentrations in the brain (including male brains), suggesting that maybe the brain was making it separately and using it for something.
Inline links: scientists found
(source) GABA is the main inhibitory neurotransmitter; it’s usually associated with relaxation and sedation. A positive allosteric modulator is a chemical that makes receptors respond more strongly to their targets. So “a positive allosteric modulator of GABA” means a chemical that makes the brain respond stronger to relaxation/sedation signals. Sounds pretty useful! You may do some positive allosteric modulation of GABA yourself sometimes; this is one of the major actions of alcohol. Also of the benzodiazepines, a popular class of psychiatric medication including Ativan (lorazepam), Valium (diazepam), and Klonopin (clonazepam). The “-pam” at the end stands for positive allosteric modulator! (or maybe that’s just an urban legend, I’ve never found proof either way) The discovery of endorphins (ie endogenous opiates) helped shed light on the brain’s reward system. So the discovery of a sort of endogenous benzodiazepine was pretty exciting. Maybe it’s some kind of master control switch for anxiety or something? Psychiatrists only know two ways to respond to an exciting new thing: publishing breathless studies claiming that it’s the true mechanism of action for SSRIs, and publishing breathless studies claiming that it’s the true biological basis of depression. This time, they did both: see eg Fluoxetine elevates allopregnanolone levels in female rat brain and The role of allopregnanolone in depressive-like behaviors. The basic theory was that stress / social isolation / etc → decreased allopregnanolone → something something BDNF and synaptogenesis → depression. And SSRIs → increased allopregnanolone → something something BDNF and synpatogenesis → recovery! Change the word “allopregnanolone”, and that’s every theory in psychiatry. But this particular theory had two extra pieces of evidence: premenstrual dysphoric disorder and postpartum depression. Remember, allopregananolone is a natural metabolite of the female hormone progesterone. Progesterone levels go up during pregnancy and the ~18th day of the menstrual cycle, then crash back down after delivery and the ~24th day of the menstrual cycle. Meanwhile, some women get depressed after delivering a baby, or on the ~24th day of their menstrual cycle. Suspicious! Maybe it’s because their progesterone was getting converted into allopregnanolone, an antidepressant hormone that affects mood! (why doesn’t every woman get PPD and PMDD? This study suggests that women with PMDD have altered sensitivity to allopregnanolone; plausibly people with PPD have some other form of altered sensitivity. In case you have the same question I do: the correlation between PMDD and PPD is not 100% but still pretty significant) History of allopregnanolone research (source) The next step was to see if making patients take allopregnanolone can treat these conditions. This is kind of hard, because allopregnanolone is a tough chemical to get into people’s bodies; the traditional method involves sticking an IV into someone and infusing it slowly over several days, and it has to be done in a hospital. Still, Kanes et al tried this in 2017. The study was open-label (ie no placebo) and very small (only four women) but appeared to work extraordinarily well. Four post-partum women who qualified as “severely depressed” when they started the infusion progressed to “completely recovered” within twelve hours. Nothing else except maybe ketamine had produced results like this before. 3: What studies were done on Zulresso? This followup study by Kanes was the first real RCT, although it only had 21 patients. In accordance with the venerable First Study Ever tradition, it found really large positive effects on post-partum depression. That encouraged Sage Therapeutics to fund a bigger Phase 3 trial, Meltzer-Brody (2018). In accordance with venerable Bigger Phase 3 Trial tradition, its results weren’t quite as good as the First Study Ever. But they were still pretty good: Notice that lower doses worked better than higher doses. This is sometimes a red flag on a study. But this time it seems legit; see “Biphasic Actions At The GABA-A Receptor” here for an explanation. Both studies also evaluated side effects. These were generally mild, but two people (about 2% of the study population) lost consciousness. Nothing seemed wrong with them, and researchers mostly attributed this to allopregnanolone being a sedating drug. If you sedate people too hard, they pass out. Faced with these results, the FDA approved allopregnanolone for post-partum depression, but subjected it to a REMS (Risk Evaluation And Mitigation Strategy) - basically, doctors who want to prescribe it will need to take special courses and do extra paperwork. This kind of surprised me - there are plenty of sedating drugs that make you pass out in overdose. Also, since patients will be getting it IV, there will probably be a nurse around to check if they passed out and take appropriate actions if so. But the FDA really likes putting restrictions on things, and I guess this was a free chance for them to do that. 4: Is Zulresso freely available at a doctor’s office near me? It’s possible to get Zulresso, but really hard. Because Zulresso is an IV infusion lasting four days, you need to spend four days somewhere that people can put an IV into you and monitor it. Realistically that means a hospital or some other big medical institution. So this is only available for inpatients. Because of the REMS (extra certification and paperwork), most hospitals aren’t interested. You can find a list of ones that are here - it looks like there are about 89 locations in the US with the right certification. Last but not least, a four-day course of Zulresso costs $35,000 for the medication itself, plus much more for the four-day hospitalization it takes to receive it. As usual, insurances will cover it iff you can document you’ve tried lots of other stuff first. 5: Hold on, does it really cost $35,000? Oho, I see you’ve played the “pharma price analysis” game before. But this time I think the price might actually be defensible. Chemical supply companies (1, 2, 3) generally sell allopregnanolone for $10,000 to $20,000 a gram. (I found one company with a much lower price, but I’m suspicious and am going to dismiss them as an outlier). The usual dose of allopregnanolone is 60 ug/kg/hour x 60 hours, which for a 60 kg person comes out to a total of 0.25g total. Getting that amount from the chemistry supply store would cost about $2,500 - 5,000. I assume pharma-grade allopregnanolone is more expensive than chemistry-store-grade, so it wouldn’t surprise me if a price in the low five-figures was justified by manufacturing alone. Isn’t it still a pretty good deal to find an endogenous neurosteroid, do one or two studies confirming it’s great, produce it for the low five figures, then sell it for the mid five figures? I think maybe not. This drug has a terrible value proposition. Post-partum depression is one of the rarer psych conditions. Most people with PPD won’t check into a hospital and pay $35,000 for a drug infusion. And the people who do will get the drug infusion, feel better, and never need it again (at least until they have another kid) - unlike SSRIs where you can keep charging for monthly prescriptions forever. Sage Therapeutics, the pharma company that owns the patent on Zulresso (and nothing else - this is their only drug!) has done terribly. Their stock is in the doldrums, they almost went bankrupt, and they survived only with the help of a cash infusion by a bigger pharma company. I think this confirms a general trend where at least some expensive medications are pricey because of fundamentals (including regulatory fundamentals) and not just pharma companies making obscene profits. 6: Hold on, how is allopregnanolone different from benzodiazepines? Remember, allopregnanolone is a positive allosteric modulator of GABA, much like benzodiazepines such as Xanax. But Xanax is cheap ($10 for 30 pills). And you can get it at any local pharmacy (plus sometimes on street corners). What’s so special about allopregnanolone that you should pay $35,000 and go into the hospital to get it? The official answer is “allopregnanolone modulates GABA differently from benzodiazepines”. For example, this paper says that: Allopregnanolone allosteric modulation of the action of GABA at GABA-A receptors is much less selective than that of benzodiazepines, which are relatively inactive at α4- or α6-containing GABA-A receptors. If you really like details about receptor subunits, this paper presents the full case. The skeptic’s answer is “who knows?” Psych drugs often work for reasons totally different than we thought. People thought tianeptine was an SSRE for years, until it turned out to be a mild opioid. People thought ketamine was NMDA-ergic for years, until it turned out to be [fill this part in 10 years from now]. Last year a bunch of very smart people tried to claim that SSRI effects had nothing to do with serotonin (I think they were wrong). Just because some guy found that Zulresso acts as a GABA-PAM in some test tube doesn’t mean that’s what’s having any of the relevant antidepressant effects. The troll’s answer is “who says it’s different?” Do benzodiazepines treat depression? Depends who you ask. If you ask benzodiazepine users, their answer is “yes, definitely”. If you ask drug warriors, their answer is “Addictive Substances May Make You Temporarily Feel Good, But They Are Not A Responsible Treatment Option”. If you ask the research literature, it gives vague indeterminate answers, as always. But nobody has ever said benzodiazepines instantly and miraculously cure depression, so how come allopregnanolone seems to do that? A true troll would point out that we probably give allopregnanolone at much higher doses - 2% of allopregnanolone patients were sedated so hard they lost consciousness, whereas this is exactly the sort of side effect I try to avoid when calculating benzodiazepine doses. Maybe if you gave postpartum women an infusion of 300 mg Valium, and maximized your placebo effect by calling it the hot new thing, they’d do pretty well too (several days later, after recovering consciousness). I think the troll answer would be hilarious but I don’t really want to defend it as correct; if I had to bet I’d say the official explanation is the right one. 7: Hold on, why can’t we just give people progesterone and let them metabolize it into allopregnanolone? This turned out to be an interesting enough rabbit hole that I’m going to spin it off into another post later this week. 8: Hold on, people have lots of allopregnanolone when they’re pregnant, right? And then post-partum depression happens when they give birth, and their allopregnanolone level drops. So if you give someone an infusion of allopregnanolone, and then take them off it, that’s a hormonal simulation of giving birth, ie the same thing that caused the problem in the first place? How is that good? Oh, you think you’re clever, do you? What you failed to consider is . . . I didn’t end that sentence because I can’t find anything in the literature addressing this question. But the difference might be that the infusion schedule ramps up gradually, peaks, and then ramps down gradually, which is more of a soft taper than the sudden crash of birth. If anyone knows more about this, please let me know. [EDIT: see this comment] 9: Is allopregnanolone addictive? No, because good luck getting addicted to a $35,000-per-dose chemical. We should probably expect allopregnanolone to be addictive, by analogy to other GABA-PAMs like benzodiazepines and alcohol. But nobody has ever received more than a single dose. You don’t get addicted to benzos after a single pill, or alcohol after a single beer, so in practice AFAIK nobody has ever gotten addicted to this. Or who knows, maybe it’s not addictive. Remember, allopregnanolone is naturally elevated during pregnancy; pregnancy isn’t addictive. And some scientists claim the brain endogenously uses allopregnanolone as a master regulator of depression and anxiety. In theory, if you could give yourself the same amount a non-anxious person’s brain gives them all the time, shouldn’t you be no worse off than that non-anxious person? I don’t know, and remember that your brain also has a lot of endogenous opioids; doesn’t make the exogenous kind any safer. The Drug Enforcement Administration has made Zulresso a Schedule IV controlled substance, which means they’re putting a few very weak restrictions on it but not worrying too much. 10: Does allopregnanolone work for depression that isn’t post-partum? If all psychiatric disorders are secretly allopregnanolone imbalances, then you might expect it to work on all depressions, not just post-partum. I’m sure pharmaceutical executives with dollar signs instead of pupils in their eyes have had this same thought, but I can’t find studies about it. Some of the same people behind the postpartum studies did a very small, very weak study on ganaloxone (a close allopregnanolone relative) for persistent depression; it seemed to work, but also caused a lot of sedation (more than in the postpartum trials? Hard to tell). Nobody’s looked into this further since then, maybe because that was around when the pharma companies realized that the 4-day hospital stay and $35,000 price tag made allopregnanolone a financial loser. The evidence from zuranolone (see below) suggests that allopregnanolone might not work very well against regular depression. 11: What is zuranolone? Wikipedia describes zuranolone as “a swirling, black vortex revered by the Mutsune Native Americans as a dire death god . . . also worshiped by mysterious servitors known as the Hidden Ones.” No! Sorry again! That’s Zushakon, another Great Old One. Zuranolone is Sage Therapeutics’ attempt to turn allopregnanolone into an accessible medication that might actually make them real money. Zuranolone is mostly just allopregnanolone with some extra stuff attached that changes the absorption. Zuranolone can be taken orally, so you don’t have to go to a hospital for four days to receive it IV. It’s potentially less likely to cause loss of consciousness and other undesirable side effects. And it’s under investigation as a potential treatment for postpartum depression, bipolar depression, regular depression, insomnia, and various movement disorders. (that might seem excessive, but benzodiazepines treat a lot of stuff, and if these neurosteroids are kind of like super-benzodiazepines, then this level of optimism might be warranted.) 12: Does zuranolone work? Sage Therapeutics answered this question the same way pharma companies answer every question: with a bunch of studies whose names form overly-cute acronyms. We’ll talk here about ROBIN, WATERFALL, MOUNTAIN, and CORAL - though I assure you there are others. ROBIN tested efficacy in postpartum depression. Results were positive and relatively impressive, about the same as the weaker allopregnanolone studies. WATERFALL, MOUNTAIN, and CORAL tested results in regular depression. WATERFALL was positive but weak. MOUNTAIN was negative. That scared the pharma company and they hacked CORAL to be more likely to give positive results. It did give positive results, but the FDA reads the same biotech magazines I do and knows perfectly well what they did, so I don’t know what Sage expects to gain from this. Overall these trials were disappointing. I think the most likely story is that allopregnanolone = zuranolone, both are moderately effective in postpartum depression, and both have much less efficacy in regular depression, probably not literally zero but also not enough to be worthwhile antidepressants (especially considering cost). Might zuranolone be an excellent anti-anxiety medication? You’d think so - it should be at least as good as benzodiazepines, which are excellent anti-anxiety medications. And researchers seem excited about allopregnanolone as a master regulator of brain anxiety. But the studies aren’t promising. ROBIN and WATERFALL incidentally assessed anxiety; ROBIN found good results in its postpartum population, but WATERFALL found poor-to-mediocre results in its regular population. Studies are hard, and sometimes even really effective drugs can have trouble showing strong results. But these aren’t encouraging. 13: So where do we go from here? Getting FDA approval for zuranolone for postpartum depression seems reasonable; it’ll probably be cheaper and easier than making people go to the hospital to get allopregnanolone. I’m uncertain about the financials of this for Sage, but since they did the study they hopefully think it’s worth it. Otherwise, I’m not sure. It would have been great if zuranolone had shown robust efficacy against regular depression and anxiety, but this is exactly the kind of great thing that never happens in psychopharmacology (motto: “Disappointing Doctors And Patients Since 1982”). It might be worth throwing it against anxiety disorders and PTSD to see if anything sticks, but I wouldn’t bet on it. The research into allopregnanolone as master regulator of brain anxiety states is fascinating, but as far as I know it hasn’t reckoned with the failure of zuranolone to really treat much anxiety. The cynical part of me predicts that once pharma’s done making money off neurosteroids then all of this will die down, and something else that pharma can make more money from will become the master regulator of everything. I expect that the main thing we get out of all this is somewhat better post-partum depression treatment, which might or might not ever become accessible for ordinary people. 14: Predictions In the next five years… Zuranolone gets FDA approval for major depression: 15%
Inline links: source, Fluoxetine elevates allopregnanolone levels in female rat brain, The role of allopregnanolone in depressive-like behaviors, This study, is not 100% but still pretty significant, https://substackcdn.com/image/fetch/$s_!WAyF!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F3c4db9d4-d5f8-45cf-8cde-17e2bbd216b6_904x334.png, source, Kanes et al, This followup study by Kanes, https://substackcdn.com/image/fetch/$s_!3b3x!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F63f81091-7084-4ad3-b0a3-28394059b2c3_369x282.png, Meltzer-Brody (2018), https://substackcdn.com/image/fetch/$s_!l7Uh!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F2b579fea-c6c8-4d46-8de7-c4a3e6852766_797x335.png, here, here, 1, 2, one company, has done terribly, this paper, this paper, tried to claim, their answer is, their answer is, it gives vague indeterminate answers, this comment, a very small, very weak study, describes, https://substackcdn.com/image/fetch/$s_!hqfF!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F5b386f78-93b3-4d16-98c4-6d2eedef5a1f_548x256.png, ROBIN, WATERFALL, MOUNTAIN, CORAL, to be more likely to give positive results
Notice that lower doses worked better than higher doses. This is sometimes a red flag on a study. But this time it seems legit; see “Biphasic Actions At The GABA-A Receptor” here for an explanation. Both studies also evaluated side effects. These were generally mild, but two people (about 2% of the study population) lost consciousness. Nothing seemed wrong with them, and researchers mostly attributed this to allopregnanolone being a sedating drug. If you sedate people too hard, they pass out. Faced with these results, the FDA approved allopregnanolone for post-partum depression, but subjected it to a REMS (Risk Evaluation And Mitigation Strategy) - basically, doctors who want to prescribe it will need to take special courses and do extra paperwork. This kind of surprised me - there are plenty of sedating drugs that make you pass out in overdose. Also, since patients will be getting it IV, there will probably be a nurse around to check if they passed out and take appropriate actions if so. But the FDA really likes putting restrictions on things, and I guess this was a free chance for them to do that. 4: Is Zulresso freely available at a doctor’s office near me? It’s possible to get Zulresso, but really hard. Because Zulresso is an IV infusion lasting four days, you need to spend four days somewhere that people can put an IV into you and monitor it. Realistically that means a hospital or some other big medical institution. So this is only available for inpatients. Because of the REMS (extra certification and paperwork), most hospitals aren’t interested. You can find a list of ones that are here - it looks like there are about 89 locations in the US with the right certification. Last but not least, a four-day course of Zulresso costs $35,000 for the medication itself, plus much more for the four-day hospitalization it takes to receive it. As usual, insurances will cover it iff you can document you’ve tried lots of other stuff first. 5: Hold on, does it really cost $35,000? Oho, I see you’ve played the “pharma price analysis” game before. But this time I think the price might actually be defensible. Chemical supply companies (1, 2, 3) generally sell allopregnanolone for $10,000 to $20,000 a gram. (I found one company with a much lower price, but I’m suspicious and am going to dismiss them as an outlier). The usual dose of allopregnanolone is 60 ug/kg/hour x 60 hours, which for a 60 kg person comes out to a total of 0.25g total. Getting that amount from the chemistry supply store would cost about $2,500 - 5,000. I assume pharma-grade allopregnanolone is more expensive than chemistry-store-grade, so it wouldn’t surprise me if a price in the low five-figures was justified by manufacturing alone. Isn’t it still a pretty good deal to find an endogenous neurosteroid, do one or two studies confirming it’s great, produce it for the low five figures, then sell it for the mid five figures? I think maybe not. This drug has a terrible value proposition. Post-partum depression is one of the rarer psych conditions. Most people with PPD won’t check into a hospital and pay $35,000 for a drug infusion. And the people who do will get the drug infusion, feel better, and never need it again (at least until they have another kid) - unlike SSRIs where you can keep charging for monthly prescriptions forever. Sage Therapeutics, the pharma company that owns the patent on Zulresso (and nothing else - this is their only drug!) has done terribly. Their stock is in the doldrums, they almost went bankrupt, and they survived only with the help of a cash infusion by a bigger pharma company. I think this confirms a general trend where at least some expensive medications are pricey because of fundamentals (including regulatory fundamentals) and not just pharma companies making obscene profits. 6: Hold on, how is allopregnanolone different from benzodiazepines? Remember, allopregnanolone is a positive allosteric modulator of GABA, much like benzodiazepines such as Xanax. But Xanax is cheap ($10 for 30 pills). And you can get it at any local pharmacy (plus sometimes on street corners). What’s so special about allopregnanolone that you should pay $35,000 and go into the hospital to get it? The official answer is “allopregnanolone modulates GABA differently from benzodiazepines”. For example, this paper says that: Allopregnanolone allosteric modulation of the action of GABA at GABA-A receptors is much less selective than that of benzodiazepines, which are relatively inactive at α4- or α6-containing GABA-A receptors. If you really like details about receptor subunits, this paper presents the full case. The skeptic’s answer is “who knows?” Psych drugs often work for reasons totally different than we thought. People thought tianeptine was an SSRE for years, until it turned out to be a mild opioid. People thought ketamine was NMDA-ergic for years, until it turned out to be [fill this part in 10 years from now]. Last year a bunch of very smart people tried to claim that SSRI effects had nothing to do with serotonin (I think they were wrong). Just because some guy found that Zulresso acts as a GABA-PAM in some test tube doesn’t mean that’s what’s having any of the relevant antidepressant effects. The troll’s answer is “who says it’s different?” Do benzodiazepines treat depression? Depends who you ask. If you ask benzodiazepine users, their answer is “yes, definitely”. If you ask drug warriors, their answer is “Addictive Substances May Make You Temporarily Feel Good, But They Are Not A Responsible Treatment Option”. If you ask the research literature, it gives vague indeterminate answers, as always. But nobody has ever said benzodiazepines instantly and miraculously cure depression, so how come allopregnanolone seems to do that? A true troll would point out that we probably give allopregnanolone at much higher doses - 2% of allopregnanolone patients were sedated so hard they lost consciousness, whereas this is exactly the sort of side effect I try to avoid when calculating benzodiazepine doses. Maybe if you gave postpartum women an infusion of 300 mg Valium, and maximized your placebo effect by calling it the hot new thing, they’d do pretty well too (several days later, after recovering consciousness). I think the troll answer would be hilarious but I don’t really want to defend it as correct; if I had to bet I’d say the official explanation is the right one. 7: Hold on, why can’t we just give people progesterone and let them metabolize it into allopregnanolone? This turned out to be an interesting enough rabbit hole that I’m going to spin it off into another post later this week. 8: Hold on, people have lots of allopregnanolone when they’re pregnant, right? And then post-partum depression happens when they give birth, and their allopregnanolone level drops. So if you give someone an infusion of allopregnanolone, and then take them off it, that’s a hormonal simulation of giving birth, ie the same thing that caused the problem in the first place? How is that good? Oh, you think you’re clever, do you? What you failed to consider is . . . I didn’t end that sentence because I can’t find anything in the literature addressing this question. But the difference might be that the infusion schedule ramps up gradually, peaks, and then ramps down gradually, which is more of a soft taper than the sudden crash of birth. If anyone knows more about this, please let me know. [EDIT: see this comment] 9: Is allopregnanolone addictive? No, because good luck getting addicted to a $35,000-per-dose chemical. We should probably expect allopregnanolone to be addictive, by analogy to other GABA-PAMs like benzodiazepines and alcohol. But nobody has ever received more than a single dose. You don’t get addicted to benzos after a single pill, or alcohol after a single beer, so in practice AFAIK nobody has ever gotten addicted to this. Or who knows, maybe it’s not addictive. Remember, allopregnanolone is naturally elevated during pregnancy; pregnancy isn’t addictive. And some scientists claim the brain endogenously uses allopregnanolone as a master regulator of depression and anxiety. In theory, if you could give yourself the same amount a non-anxious person’s brain gives them all the time, shouldn’t you be no worse off than that non-anxious person? I don’t know, and remember that your brain also has a lot of endogenous opioids; doesn’t make the exogenous kind any safer. The Drug Enforcement Administration has made Zulresso a Schedule IV controlled substance, which means they’re putting a few very weak restrictions on it but not worrying too much. 10: Does allopregnanolone work for depression that isn’t post-partum? If all psychiatric disorders are secretly allopregnanolone imbalances, then you might expect it to work on all depressions, not just post-partum. I’m sure pharmaceutical executives with dollar signs instead of pupils in their eyes have had this same thought, but I can’t find studies about it. Some of the same people behind the postpartum studies did a very small, very weak study on ganaloxone (a close allopregnanolone relative) for persistent depression; it seemed to work, but also caused a lot of sedation (more than in the postpartum trials? Hard to tell). Nobody’s looked into this further since then, maybe because that was around when the pharma companies realized that the 4-day hospital stay and $35,000 price tag made allopregnanolone a financial loser. The evidence from zuranolone (see below) suggests that allopregnanolone might not work very well against regular depression. 11: What is zuranolone? Wikipedia describes zuranolone as “a swirling, black vortex revered by the Mutsune Native Americans as a dire death god . . . also worshiped by mysterious servitors known as the Hidden Ones.” No! Sorry again! That’s Zushakon, another Great Old One. Zuranolone is Sage Therapeutics’ attempt to turn allopregnanolone into an accessible medication that might actually make them real money. Zuranolone is mostly just allopregnanolone with some extra stuff attached that changes the absorption. Zuranolone can be taken orally, so you don’t have to go to a hospital for four days to receive it IV. It’s potentially less likely to cause loss of consciousness and other undesirable side effects. And it’s under investigation as a potential treatment for postpartum depression, bipolar depression, regular depression, insomnia, and various movement disorders. (that might seem excessive, but benzodiazepines treat a lot of stuff, and if these neurosteroids are kind of like super-benzodiazepines, then this level of optimism might be warranted.) 12: Does zuranolone work? Sage Therapeutics answered this question the same way pharma companies answer every question: with a bunch of studies whose names form overly-cute acronyms. We’ll talk here about ROBIN, WATERFALL, MOUNTAIN, and CORAL - though I assure you there are others. ROBIN tested efficacy in postpartum depression. Results were positive and relatively impressive, about the same as the weaker allopregnanolone studies. WATERFALL, MOUNTAIN, and CORAL tested results in regular depression. WATERFALL was positive but weak. MOUNTAIN was negative. That scared the pharma company and they hacked CORAL to be more likely to give positive results. It did give positive results, but the FDA reads the same biotech magazines I do and knows perfectly well what they did, so I don’t know what Sage expects to gain from this. Overall these trials were disappointing. I think the most likely story is that allopregnanolone = zuranolone, both are moderately effective in postpartum depression, and both have much less efficacy in regular depression, probably not literally zero but also not enough to be worthwhile antidepressants (especially considering cost). Might zuranolone be an excellent anti-anxiety medication? You’d think so - it should be at least as good as benzodiazepines, which are excellent anti-anxiety medications. And researchers seem excited about allopregnanolone as a master regulator of brain anxiety. But the studies aren’t promising. ROBIN and WATERFALL incidentally assessed anxiety; ROBIN found good results in its postpartum population, but WATERFALL found poor-to-mediocre results in its regular population. Studies are hard, and sometimes even really effective drugs can have trouble showing strong results. But these aren’t encouraging. 13: So where do we go from here? Getting FDA approval for zuranolone for postpartum depression seems reasonable; it’ll probably be cheaper and easier than making people go to the hospital to get allopregnanolone. I’m uncertain about the financials of this for Sage, but since they did the study they hopefully think it’s worth it. Otherwise, I’m not sure. It would have been great if zuranolone had shown robust efficacy against regular depression and anxiety, but this is exactly the kind of great thing that never happens in psychopharmacology (motto: “Disappointing Doctors And Patients Since 1982”). It might be worth throwing it against anxiety disorders and PTSD to see if anything sticks, but I wouldn’t bet on it. The research into allopregnanolone as master regulator of brain anxiety states is fascinating, but as far as I know it hasn’t reckoned with the failure of zuranolone to really treat much anxiety. The cynical part of me predicts that once pharma’s done making money off neurosteroids then all of this will die down, and something else that pharma can make more money from will become the master regulator of everything. I expect that the main thing we get out of all this is somewhat better post-partum depression treatment, which might or might not ever become accessible for ordinary people. 14: Predictions In the next five years… Zuranolone gets FDA approval for major depression: 15%
Inline links: here, here, 1, 2, one company, has done terribly, this paper, this paper, tried to claim, their answer is, their answer is, it gives vague indeterminate answers, this comment, a very small, very weak study, describes, https://substackcdn.com/image/fetch/$s_!hqfF!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F5b386f78-93b3-4d16-98c4-6d2eedef5a1f_548x256.png, ROBIN, WATERFALL, MOUNTAIN, CORAL, to be more likely to give positive results
Progesterone Megadoses Might Be A Cheap Zulresso Substitute
March 10, 2022 · Original source
But Zulresso is a natural metabolite of the female hormone progesterone. What’s stopping people from taking progesterone, waiting for their bodies to metabolize it into Zulresso, and saving $35,000 and a hospital stay?
Andreen et al give some people a dose of 20 mg progesterone, then measure allopregnanolone levels. They find that the progesterone gets converted into allopregnanolone, with a max plasma concentration of about 8 nmol/L. This is about a fifth of allopregnanolone levels during pregnancy, which a course of Zulresso is trying to match. So in theory (and assuming simple pharmacokinetics) a dose of 100 mg progesterone ought to give the same peak level of allopregnanolone as a Zulresso infusion.
Inline links: Andreen et al
The only people I can find who take this to its logical conclusion are Barak & Glue. They do the same calculation as above much more rigorously, and suggest that the following progesterone regimen would correspond to the typical Zulresso infusion:
Inline links: Barak & Glue
Highlights From The Comments On Zulresso
March 16, 2022 · Original source
Thanks to everyone who commented on Zounds! It’s Zulresso and Zuranolone and on the followup Progesterone Megadoses Might Be A Cheap Zulresso Substitute. I’m constantly impressed by the expertise of commenters here and on how much better the biomedical comment threads are compared to some of the others. Among the things I learned:
Inline links: Zounds! It’s Zulresso and Zuranolone, Progesterone Megadoses Might Be A Cheap Zulresso Substitute
He also wrote a longer blog post about the science of progesterone here.
Inline links: here
— Thomas Reilly has a new blog Rational Psychiatry where he’s written up some more info on premenstrual dysphoria and progesterone. For example:
Inline links: Rational Psychiatry, some more info
Prohibition3 mentions across 3 issues

Prohibition is a recurring concept in the Astral Codex Ten archive, appearing 3 times across 3 issues between April 27, 2023 and March 19, 2026. The archive places it in contexts such as "Geeks were often alcoholics or drug addicts, and paid with liquor – especially during Prohibition – or with narcotics"; "‘the resulting boom in alcoholism provoked a backlash that ultimately led to Prohibition’"; "John Rawls the alcoholic was twelve when they lifted Prohibition". It most often appears alongside 286, 8088, Adorno.

Article page
Prohibition
Mention count
3
Issue count
3
First seen
April 27, 2023
Last seen
March 19, 2026
Outbound links
Issue trail
Related pages
Source context
Highlights From The Comments On Nerds And Hipsters
April 27, 2023 · Original source
…where Sam fills in the northwest and southeast squares, then claims a correlation, draws a line, and points to high-status/deep-engagement as a single unified concept. But the southwest square could be “writes a wacky Shakespeare fanfiction, Romeo & Juliet II, in blank verse and period-appropriate language”, and the northeast square could be “publishes a dissertation on some irrelevant aspect of word frequency changes across English plays to prove something about linguistics”. And then having conflated these two things, he goes on to conflate a third thing, Shakespeare vs. Marvel. I’m not up to date on what goes on in academic literature departments, but Freddie de Boer says they’re increasingly offering “Spiderman Studies” classes in attempts to stay culturally relevant; probably Spiderman professors engage with Spiderman on the same deep level that Shakespeare professors engage with Shakespeare. If we made this a cube - high-status vs. low-status forms of engagement along one axis, Shakespeare vs. Spiderman along another axis, and deep vs. shallow engagement along the third - would anything be left of the “nerd” cluster as Sam describes it? I’m not sure. 2. Comments With Strong Opinions On The Definition Of Nerds, Geeks, Etc There were many of these. One common theme was that in the 70s, “nerd” was almost synonymous with “person who is only into unpopular things”, for example sci-fi, comics, and RPGs, all of which were unpopular in the 70s. Then those things became very popular, but the people who were interested in them still get called “nerds”. So now people like Kriss use “nerd” almost synonymously with “person who is only into popular things”. So we have a word which denotes either interest in unpopular things or interest in popular things, depending on who’s using it and when they last updated their lexicon. In the 70s, it was more reasonable to group “interested in math and computers” and “interested in sci-fi and RPGs” together, because both were unpopular and tended to involve the same group of socially maladept young men. Now math is still hard and unpopular; computers are hard in the sense that it’s tough to learn programming languages, but universally used and beloved; sci-fi and RPGs are very popular, and the typical sci-fi fan is closer to a socially-adept albeit “quirky” young woman. If words are hidden inferences, the inference represented by “nerd” - that sci-fi fandom, interest in math, interest in computers, maleness, poor social skills, and nonconformity with mainstream interests all go together - is now thoroughly false, dooming us to conversations like this one. Attempts to repurpose the several different words used to refer to the math/sci-fi/awkward/unpopular cluster to represent different aspects of its successor clusters have mostly failed. Sample comments from this section: Coagulopath writes: To me, being a nerd requires a degree of swimming against the cultural tide. It's weird and unpopular to be into trains, so the fact that you are indicates you have a bit of character (or are socially oblivious, which is also kind of endearing). The problem (and I think Kriss alludes to this) is that nerd stuff went mainstream in the past few decades. Of the 10 highest-grossing movies of the 2010s, 6 are Star Wars or Marvel films. There's no longer any sense that nerds are the underdog. But what does it say about you when you wear a Star Wars shirt? You're pledging allegiance to the biggest, most popular club imaginable. Is that a brave stance? Those people always make me think "if you lived in the SW universe, you'd be on the side of the Empire". In general, I am creeped out by effusive public adoration for things that are near-universally loved. Like The Beatles. Or bacon. Or dogs. Or science (Neil DeGrasse Tyson's whole shtick). Regardless of how I feel about those things on the object level, there's no glory in joining a culture war when you're signing on to the winning side. Tolaughoftenandmuch writes: All this is so different from when I was a kid. I was a nerd because I was intellectually curious, bad at and disinterested in sports, socially awkward, and had a computer hobby (owning hardware C64 ->8088 ->286, writing programs in Basic, being a BBS SysOp). Cultural interests were irrelevant to my nerd status. In terms of exactly when nerd interests started becoming popular, Ghatanathoah writes: I also wouldn't say that nerd stuff only went mainstream in the last decade, it's not like the first 3 Star Wars movies were obscure arthouse pictures. I think the reason Marvel took off is just innovations in storytelling: movie producers finally figured out a way to adapt the gloriously arcane and convoluted lore of superhero comics in a way that could appeal to mainstream audiences in addition to nerds (much how George Lucas figured out how to get mainstream audiences to love the space operas nerds had been enjoying for decades before 1977). And Melvin writes: Comic book movies had always been pretty popular. Superman was the top grossing movie of 1979 despite coming out in 1978. Superman 2 was the second top grossing movie of 1981. Batman was the second top grossing movie of 1989. Batman Returns was the top grossing movie of 1992. Batman Forever was the top grossing movie of 1995. Spider-man was the third top grossing movie of 2002 (behind Lord of the Rings and Harry Potter movies). That's about all I can be bothered looking up right now but you get the idea, superhero movies have been popular since the 1970s. Kaitian writes: I think being a nerd requires being a bit socially clumsy about your interest, and talking or signalling about it in situations where most people don't expect it. So being a nerd about completely mainstream stuff like pop music or football is not possible, that's just fandom. Being a nerd about very well known and relatively well-respected stuff like classical music or birdwatching is rare, because most people who are classy enough to care about the thing in the first place are also classy enough to know when to shut up about it. But comics? Star trek? Power metal? They have fairly low barriers to entry *and* most people don't care about them, so there's plenty of opportunities to bring it up to people who don't want to hear about it. So that's why I think nerdery usually attaches itself to the typical targets. J.R. Leonard has as good a terminology proposal as anyone: I think what's missing is that Kriss uses "nerds" as his foil, but what he's talking about would better be described as fan culture. Deiseach teaches us the etymology of “geek”. The very distant etymology is from German gek, a relative of “cackle” → geck, a fool/madman (who was presumably cackling all the time). But this comes down to us through the early American institution of the geek show. From Wikipedia (cw: disturbing): Geek shows were an act in traveling carnivals and circuses of early America and were often part of a larger sideshow. The billed performer's act consisted of a single geek, who stood in the center ring to chase live chickens. It ended with the performer biting the chickens' heads off and swallowing them. The geek shows were often used as openers for what are commonly known as freak shows. It was a matter of pride among circus and carnival professionals not to have traveled with a troupe that included geeks. Geeks were often alcoholics or drug addicts, and paid with liquor – especially during Prohibition – or with narcotics. More obvious but I went surprisingly long without realizing it: “fan” (as in “sports fan”) is just short for fanatic. 3. Comments About Collecting The veteran collectors in the comments said that my theory (the Internet makes collecting too easy) was only a small part of the decline. The bigger part is that most coin collecting begins with the wonder of finding a rare coin in your change, and most stamp collecting begins with the wonder of finding a rare stamp on your mail, and the rise of credit cards and emails means people aren’t handling coins and stamps as much in their daily lives. Tom Metcalf writes: I'd guess many coin collectors got their start being patient enough to sort through change to see if they had e.g. a wheat cent or silver dime, but first of all, who pays with cash and gets change, and the chances of finding something collectible are orders of magnitude smaller than, say, the '90s. And stamp collectors would have started saving the stamps on mail sent to their house, but how frequently do you get stamped mail anymore? My 79-year old father goes to stamp shows, because one of his hobbies is to buy sheets of old but common unused stamps for less than face value. They are still valid postage, and then he uses them to personalize the stamps he puts on letters he sends to various people. And most of the other people at stamp shows are about his age. He does have some stamps he thinks are interesting that he's held onto, but the dealers at the stamp shows think they're common and uninteresting. So there's a decreasing number of stamps that might be "worth something" and a net loss of collectors in the hobby, and then every time a collector dies and his heirs have no interest in his collection and that many more stamps make their way to dealers who now have one less buyer. Too bad "sending paper letters with vintage but still valid stamps" never caught on with the hipsters. Art writes: The widespread adoption of email created a world where a letter is almost certainly junk mail or a bill. Nobody looks forward to hearing from a good friend from across the country now when picking up the day’s mail. If letters are not interesting why would stamps? The same for coins. Nobody uses cash, and getting a pile of coins with no significant value (inflation) is just an annoyance. These objects have passed into irrelevance. Still, it seems like some little pieces of joy and wonder have passed from our lives. Nathan Savir writes: I collect coins and I think the description of the hobby (and its putative death) isn't quite right. 1. Rare coins are in fact hard to find, even in today's internet world. They are usually sold in auctions, which might happen online, but still not that frequently. It's not unusual for examples some specific rare coin to be sold only once every few years. If the coin is also obscure, it may not be prohibitively expensive, so this kind of situation isn't the sole province of rich people. 2. One area of collecting is to get all the rare items. Another is to get all the minor varieties of a common item. These varieties may not be very rare, but it still takes a lot of effort to be able to distinguish them and to find them. Some collectors will obtain large numbers of relatively common coins and sort through and scrutinize them to try to identify interesting varieties. 3. An important part of collecting is getting good deals. This is surely a lot harder than it used to be because sellers can more easily figure out what things are worth and you won't find something grossly underpriced in a random antique store as often these days. But filtering through buckets (or online listings) of large numbers of coins can still be fun and lead to spotting good deals. So I think there is room in the hobby for nerd-like behavior (per your definition). I would argue the decline of the hobby is more due to competition from other similar hobbies (a generation ago you could collect stamps, coins, baseball cards, or rare books/comics - now you can collect beanie babies, Pokemon cards, NFTs, funko pops, action figures, etc.). I think stamps have suffered more than coins because stamp collecting has more of an aesthetic component (which has faced stronger competition) while coins have a historical element that is less well replicated by collecting newer things. This difference isn't obvious in the google trends graphs you posted but I believe is observable from looking at prices of stamps vs coins. I asked Nathan what coins he collects that are still tough to find, and he gave the example of this Yuan dynasty coin from 1350. I guess if you want to be a collector in 2023 you need to go hard. Arrk Mindmaster writes: I used to collect US coins from every denomination, year, mint, and variety (such as large and small date 1960 pennies). It was kind of like a treasure hunt, knowing you could find something in circulation that was actually more valuable than most people thought it was. I lost interest in the late 1980s sometime, when I found the volume of new coins dwarfed older coins. For example, for Lincoln pennies, they used to make a few million per year, then a few tens of millions. In the 80s, they started making about 5 BILLION each, and it started drowning out all of the old coins, which basically stayed the same value. This comment snapped some things into place for me; I collected coins as a kid in the 90s, and older coin collectors would talk as if you could spot some pretty rare things in your pocket change. But I had much worse luck, and it’s been years since I’ve even found a wheat cent in circulation (even when I was a kid this would happen occasionally). Maybe coin collecting is dying not just because we don’t use change, but because our change is less likely to have interesting coins in it. Another victim of mass money printing! The new state quarters sort of fix this, but other commenters express contempt for this. It feels like the transition between old myths (which one can enjoy) to the Marvel Cinematic Universe (which corporations are begging you to enjoy in a pre-approved way) - now that the Mint wants you to collect their coins, it feels kind of slavish to comply. Other people point out that the collecting of things other than stamps and coins is still going strong. Drethelin: Collecting has not in the slightest died out. People collect more things than ever, like sneakers, funko pops, vintage cars, guns, antique ceramics, anime figurines, magic cards, etc. Some people also brought up NFTs - are there lots of people who truly enjoy collecting NFTs, aren’t just in it for the investment value, and have kept up through the crypto bear market? 4. Comments Insisting That Sports Are Good Aris C writes: It's a little glib to dismiss sports as bad, isn't it? Athletes display extreme skill, sometimes transcendent. I don't think watching people push the limits of human ability is obviously bad. When I said sports were bad, I didn’t mean this as a final value judgment. I meant that, by our usual standards of entertainment, sports are bad. Imagine a sitcom which had several thousand episodes, each with the exact same plot (some people try to get a ball from one side of the court to the other). At some point, surely most people would stop watching! I appreciate the something something human spirit, and I’m happy to know that, somewhere in the world, sports are happening. It’s just the decision to actually watch them that confuses me. 5. Comments About Enjoying Things Vs. Building Identities Around Them Many people complained that some combination of me and/or Sam Kriss were denying that anyone can ever enjoy anything except as an attempt to “gain status”. I would answer first that yes, I think most behavior has some status component (although it may be a small component, mixed with genuine enjoyment). But also, it doesn’t seem mysterious that some people eg like Star Wars, or even love Star Wars. What seems mysterious to me is when this expresses itself as desire to buy thousands of dollars of figurines in the original boxes, or memorize the stats of every class of ship in the Imperial Navy, or something else which doesn’t seem very fun on its own merits. I’m not criticizing others from a place of invulnerability here. When I was ~14, I got really into Star Wars, and aside from reading all the Extended Universe books - some of which were genuinely very good - for about a year I spent all of my allowance and a good fraction of my free time obtaining Star Wars collectable cards associated with an M:TG style card game (which I never got around to playing). My parents probably still have them somewhere. I cannot at all retrace what led me to do this, but I appreciate commenters’ less cynical explanations. For example, enchantingacacia writes: I think it's honestly sort of funny how non-nerds seem to genuinely not understand that a nerd's identity becomes about [thing] because they like it so much, not the other way around. Sometimes you encounter a thing—let's say it's Minecraft, because why not—and it's just such a positive experience for you that you take every possible opportunity to keep thinking about Minecraft, even when you're not playing. You collect every scrap of information you can find about Minecraft and you compose your own original Minecraft-related songs and you decorate your room with blocky little figurines. You get into a virtuous cycle where talking and thinking about Minecraft is so rewarding that you keep enjoying all these secondary activities long after you're bored of actually playing Minecraft itself. You look out for opportunities to meet people who'd enjoy talking about Minecraft with you and make a bunch of friends with whom you mostly talk about Minecraft, and your friends and family start seeing you as "the Minecraft guy" and they get you a Minecraft hoodie for Christmas cause they know it's a safe pick. This is the obvious and intuitive explanation! There's no need to get fake-deep about "ah, they got into Minecraft so they'd have something to construct their identity around": it explains nothing, and consistently makes incorrect predictions about the internal experiences of Minecraft nerds. It's only virtue is making people feel better about being annoyed by those weirdos who won't shut up about Minecraft. It's possibly that I have unusually low social motivation (genuinely, what does it mean to "construct your identity" and why is it something people would be this comically desperate to do?) and am typical-minding, but, uh, I wonder if there's any group closely associated with "nerds" who are also known for having low social motivation? I think it's a tad more likely that people like Kriss are typical-minding, and constructing elaborate social motivations for people who just like stuff regardless of what people like him think. This is a good comment which avoids buck-passing-style “I enjoy it because it’s fun” explanations. Along the same lines, odd anon writes: It is only among nerds that enthusiasm for something corresponds to learning more and more about it. That's the core element here. Non-nerds who like something do not feel any need to read up on it, to know more and more. Of course, the producers of content notice when their audience are nerds, and they start to produce content built more for those who obsessively learn every detail. Comics can start "rewarding" readers for noticing some obscure thing. A game series can have an elaborate continuity, or a zillion details to memorize. Content that either "leans into the fandom" or simply naturally has too much for non-nerds to easily pick up, can rapidly become nerd-only, thus solidifying boundaries. And sure, there are the personality correlations, attributes most nerds also have, including being STEM-y and lacking social skills. Combined, a nerd ended up being an unpopular thing to be. Ghatanathoah is less patient: Both Kriss' essay, and Scott's response to it, remind me of the "Evil Cannot Comprehend Good" trope from TV tropes, except replace "Evil" with "Very socially motivated people" and "Good" with "Less socially motivated people" (although honestly both sets have a lot of overlap). Both essays seem obsessed with finding some deep, social reason why hipsters and nerds behave the way they do, like the supervillain who is telling the hero that they are "Not So Different." They literally can't comprehend the idea that someone could actually like something, so they try desperately to find some way that liking things isn't something people actually do. People couldn't actually like Star Wars, sportsball, the MCU, or the Beatles, they must be liking them to achieve some social goal like forming an identity or seeking status! This is one of the two giant flawed assumptions that invalidates the theses of both articles (the other one, of course, is the assumption the the MCU is bad, when it is, in fact one of the human race's greatest artistic achievements*). If you assume that it is possible to like things for non-social reasons, or even in addition to social reasons, hipsters and nerds make much more sense. The reason that nerds like both popular stuff like the MCU, and less popular stuff like postage stamps is because they don't care about if something is popular, they care about if it fascinates them. Whether that thing is popular is orthogonal to how fascinating it is. That fascination makes them invest a lot of time and effort in it, which in turn makes it part of their identity. They weren't trying to find something to form and identity first and picking Star Wars, identity formation was just a side effect. Similarly, hipsters probably just get bored with things they see frequently and want to seek out new things to be interested in. Making obscure things part of their identity comes second, if at all. Also Ghatanathoah: Scott asks if its ever okay to build your identity around liking a thing. I would ask if it's ever okay not to? What's the alternative, building it around social status games or large nonselective identity groups? It seems to me that liking something isn't just a good thing to build your identity around, it's one of the best things to build it around. After all, unlike social status games, you can like something without forcing other people to not like it. This is a good question, well-phrased. I think the traditional answer is that you should build your identity around social relationships (I’m the son of X, husband of Y, friend of Z), career, and maybe a few hobbies. I agree with this as far as it goes, but it doesn’t work for a lot of practical tasks - I can’t get common ground with someone at a party or start a conversation by introducing myself as the son of X or husband of Y - most people just won’t know X or Y. Some people linked a Freddie de Boer post, Your Personality Has To Be Load-Bearing, which is generally good but I think has a similar problem. Obviously you should have a genuine and complex personality, but I worry a lot of people who talk about this will reject every specific aspect of personality because “it’s not, in itself, a full complex personality!”, but you can’t have a personality without building it out of specific aspects. A lot of people’s default personality, if they just do exactly what comes naturally and don’t put any effort into self-presentation or cultivation, is to browse Reddit and play video games. Most people realize this on some level and try to cultivate some personality beyond this, but I think that makes it extra unfair to say “Just use your natural true self!” The natural true self is exactly the boring thing we’re trying to get away from in favor of becoming a more interesting person. I’m trying to think if I have a personal answer to this. Part of my answer is the EA and rationalist communities. This has some downsides; I’m thinner-skinned about insults to these groups than I should be; some people might think I’m a fanatic. It also has some upsides; they embody real values I like, they try to make a difference in the world, they’re not consumer properties that make me feel like a corporation is pulling my strings. But my real answer is probably “I cheat by having a popular blog; this means you all know everything about me and I don’t have to fit my personality into a ten-second elevator pitch”. Maybe this is the traditional solution, from back when everyone knew everyone else in their community. It sure doesn’t feel adequate now, back when (non-bloggers) are constantly meeting strangers and having to communicate their identity to them quickly. My internal hierarchy of things it’s virtuous to build identity around, which is probably a weird class artifact and which I absolutely don’t consciously endorse, goes something like: Top-tier: Intellectual subfields, especially obscure ones or ones involving pure abstract math. If you can say “I’m really into trans-finite 8-dimensional Hoffdorf groups” and justify this with a discussion of how innately beautiful they are, you’ve got it made.
Inline links: words are hidden inferences, writes, Tolaughoftenandmuch, writes, writes, writes, J.R. Leonard has, teaches us the etymology of “geek”, From Wikipedia, writes, writes, writes, this Yuan dynasty coin from 1350, writes, other, commenters, Drethelin, writes, enchantingacacia writes, odd anon writes, is less patient, Your Personality Has To Be Load-Bearing
Shameless Guesses, Not Hallucinations
March 16, 2026 · Original source
The cotton gin was invented by Thomas Edison in 1910. It was important because gin made with cotton, of which the Southern plantation economy produced a surplus, was cheaper than the usual gin made with juniper berries. This lowered the price of alcoholic spirits considerably. According to historian John Smith in his seminal The Invention Of The Cotton Gin For Dummies, the resulting boom in alcoholism provoked a backlash that ultimately led to Prohibition.
Being John Rawls
March 19, 2026 · Original source
John Rawls the alcoholic was twelve when they lifted Prohibition. He partook immediately, and dropped out of school the following year, supporting himself through a combination of odd jobs, petty crime, and handouts. When he was 41, he committed a not-so-petty crime - killing a man in a bar fight. Although he fled the scene and escaped without consequences, it turned him paranoid. Odd jobs and petty crime were both young men’s games, and the handouts became an ever-larger share of his income. He learned to play the field, peddling the same sob story to the Salvation Army on Monday Wednesday Friday, the YMCA Tuesday and Thursday, and the local churches on weekends. He expected to drink himself to death by age 60, and there wasn’t much to do but wait out the clock.
Prop 363 mentions across 3 issues

Prop 36 is a recurring concept in the Astral Codex Ten archive, appearing 3 times across 3 issues between October 22, 2024 and November 04, 2024. The archive places it in contexts such as "ngest disagreement was over Prop 36, which increases penalties for various crimes"; "Prop 36 doesn’t just raise drug crimes from misdemeanors to felonies"; "Prop 36 requires that the court refer patients". It most often appears alongside San Francisco, Boston, Los Angeles.

Article page
Prop 36
Mention count
3
Issue count
3
First seen
October 22, 2024
Last seen
November 04, 2024
Outbound links
Issue trail
Related pages
Source context
ACX Local Voting Guides
October 22, 2024 · Original source
The strongest disagreement was over Prop 36, which increases penalties for various crimes. I’m hoping to publish a guest post on this one later this week. Kudos to ACX Oakland for including district maps and recommendations for various transit and utility positions.
The Case Against California Proposition 36
October 29, 2024 · Original source
Proposition 36 is a California ballot measure that increases mandatory sentences for certain drug and theft crimes.
The campaign for Prop 36 is based on the premise that Prop 47 failed, leading to increased drug use and retail theft (but don’t trust me – it says so in the text of the measure). 36 would repeal some parts of 47, add some additional sentencing increases, and leave some elements in place (the LA Times has a good breakdown of the changes here).
Inline links: text, here
It’s easy to round this off to a simple tradeoff: are we willing to put tens of thousands of people in jail if it would decrease the crime rate? But this would be the wrong way to think about the measure: there is no tradeoff. Prop 36 will certainly imprison many people, but it won’t help fight crime.
Open Thread 354
November 04, 2024 · Original source
1: Comment of the week is Graham on the Prop 36 post - he argues that the reason cops aren’t enforcing the existing misdemeanor penalty for shoplifting (up to six months in jail) is that by the time it gets through the DAs, this is reduced to “a stern talking to”, and it’s not worth cops’ time to arrest anyone who won’t be punished. Therefore, in order to get the six months in jail that’s already on the books, we apparently have to increase the law to three years in jail. I appreciate this perspective, but it only leaves me more confused - for example, didn’t San Francisco recall its soft-on-crime DA and replace him with a tough-on-crime DA who promised to throw the book at shoplifters? Don’t these charts from the San Francisco DA show that most arrests lead to charges, and the problem is almost entirely that most reports don’t lead to arrests? I still don’t feel like I understand the dynamics behind why our current laws can’t be used to arrest and imprison shoplifters.
Inline links: Graham on the Prop 36 post, these charts
Prop 473 mentions across 3 issues

Prop 47 is a recurring concept in the Astral Codex Ten archive, appearing 3 times across 3 issues between June 23, 2022 and October 29, 2024. The archive places it in contexts such as "like Prop 47 or soft-on-crime progressive policies"; "Changes in reporting caused by Prop 47"; "it has nothing to do with Prop 47". It most often appears alongside Bay Area, California, Los Angeles.

Article page
Prop 47
Mention count
3
Issue count
3
First seen
June 23, 2022
Last seen
October 29, 2024
Outbound links
Issue trail
Related pages
Source context
Book Review: San Fransicko
June 23, 2022 · Original source
Source: Ed West, do note that this example is from the UK How suspicious should we be of each type of story? There will always be an extreme right tail of overly harsh sentences, and an extreme left tail of overly lenient ones. Were the 2000s really as draconian as they felt? Is the modern era really as pathetic? Or is it all just a function of who you read and what agenda they’re pushing? Shellenberger: During California governor Jerry Brown’s time in office, voters passed several reforms aimed at reducing the size of the prison population. In 2012, voters passed a change to the Three Strikes law so that the third strike imposes a life sentence only if the new felony was serious or violent. In addition to lowering punishments for drug possession, Proposition 47, which voters passed in 2014, redefined shoplifting, forgery, petty theft, and receiving stolen property as misdemeanors when the value in question does not exceed $950. In 2016, voters approved a proposition that shortened the time it took for some nonviolent offenders to be eligible for parole and which released nonviolent offenders into drug treatment and rehabilitation. Property crimes rose in San Francisco starting in 2012. Larceny, which is shoplifting and other petty theft, rose 50 percent, from roughly 3,000 incidents per 100,000 people in 2011 to about 4,500 in 2019. Property crimes as a whole, which include larceny, motor vehicle theft, and burglary, rose from 4,000 incidents per 100,000 people in 2011 to 5,500 in 2019. One study suggests that Proposition 47 increased the rate of auto theft 17 percent and the rate of larceny (non-auto property) theft 9 percent, but discerning between causation and correlation may not be possible. Upon taking office in January 2020, [famously soft-on-crime San Francisco district attorney Chesa] Boudin followed through on his campaign promises. Instead of prosecuting and incarcerating people for breaking car windows to steal money and other items from inside, Boudin proposed creating a $1.5 million fund to reimburse car owners. But there were over 25,000 car break-ins reported in 2019. If every break-in cost just $250 in repairs, the fund would need four times that amount. And what would prevent people from falsely claiming to have been robbed in order to get city money? […] Boudin opposed efforts by the mayor and the city attorney to prevent drug dealers who had already been arrested from entering the Tenderloin. “Until the city is serious about treating addiction and the root causes of drug use and selling,” said Boudin in a statement, “these recycled, punishment-focused approaches are unlikely to succeed at doing anything more than making headlines.” Home burglaries rose in early 2021 in San Francisco. Homeowners started posting on Twitter videos from their security cameras of people breaking into homes and garages. “When I first moved here we had a car break-in problem,” said Michael Solana, a writer who works for a venture capital fund. “Now we have a home invasion problem. These things are wearing on people.” Boudin attributed the rise of burglaries in San Francisco to the decline of tourism and “people in desperate economic circumstances.” Progressive supervisor Hillary Ronen agreed. “We know that [economic insecurity and inequality] is one of the root causes of property crimes specifically,” she said. But Tom Wolf and others argued that the robberies were, like the shoplifting, done by people seeking money to buy drugs and feed their addictions. “The drugstores have been shoplifted to death and that’s all because of drug use,” said Tom. “I know. I used to do the same thing when I was out there. That’s what you do. You ‘boost.’ And then you go and you sell your stuff down at UN Plaza,” an open-air drug scene. In a May 2021 city supervisors’ meeting, a representative from CVS called San Francisco “the epicenter of organized retail crime in the country” and claimed that 85 percent of the shoplifting is committed by organized theft rings. Police broke up one such ring in October 2020 and recovered $8 million of stolen merchandise. The problem goes beyond property crime. Boudin declined to prosecute two men who went on to kill people. One man had been repeatedly arrested for stealing cars, despite having just been released from prison earlier in the year, and appeared to be abusing meth. On New Year’s Eve, 2020, the man killed two people while driving intoxicated. Police found inside of his car a semiautomatic handgun and twenty-three grams of methamphetamine. On February 4, another intoxicated driver killed a pedestrian in a stolen car. The San Francisco police had arrested him in October 2020 for possessing a stolen car, a tool for stealing cars, and what appeared to be meth. Boudin chose not to pursue charges. In December, the California Highway Patrol arrested the man again for driving a stolen vehicle under the influence. Again he was not prosecuted. The accident victim, an immigrant from Kenya, and his wife had moved to San Francisco two weeks before the fatal crash. “I blame the DA,” said the widow of the victim. The suspect, she said, “was someone who was out in the public who shouldn’t have been in the public. It was completely avoidable.” Tom said he could feel the difference on the streets. “Drug dealing is unabated and it’s not one guy, it’s fifty guys dealing fentanyl and meth,” he said. “And it’s going unabated because the district attorney says, ‘These are the nonviolent, quality-of-life crimes,’ and ‘I’m not going to prosecute them.’” [..] District Attorney Boudin was offering weaker sentences than even defense attorneys were requesting, according to Vicki Westbrook of San Francisco. “There’s a defense attorney who said, ‘It used to be that I would argue for this deal in court with the DA but now I don’t say anything because the DA is going to offer me a deal better than what I would have suggested. Somebody shot up the street with an automatic weapon. The first offer was six months in jail or time served plus two years of probation or something. And then [the DA] said, “How about thirty days in jail?”’” Vicki laughed. “You really can do anything in San Francisco,” she said. “If you do get arrested, chances are you’re going to be out of jail in less than thirty days for damn near everything except maybe killing somebody and maybe even then, too. It’s hard to say at this point.” Taking each of these points individually: Proposition 47 There are two good big studies on the effects of Prop 47, one by Public Policy Institute and one by some UCI criminologists. The PPI study finds that the proposition increased theft and car break-ins by about 10%. The UCI study finds the same, but notes that under different assumptions the effects wouldn’t quite obtain statistical significance. This seems a bit too much like post hoc trying to get rid of an inconvenient effect, plus an effect on the border of statistical significance is different from positively finding no effect. I think a reasonable interpretation is that theft and car break-ins rose about 10% because of the proposition, just as Shellenberger says. Some pro-47 sites note that most states have some limit on how much you to have to shoplift before it’s a felony, and Prop 47 brought California closer to the national average, rather than turning it into an outlier. Chesa Boudin Chesa Boudin took office two months before the COVID pandemic began. Any attempt to separate the effect of Chesa Boudin from the effect of the pandemic is doomed. Shoplifting definitely plummeted when Boudin took office, but that’s because all the stores were closed. Murders definitely rose a little after Boudin took office, but that’s because that was also when the Black Lives Matter protests happened, which demoralized police and led to a so-far-permanent spike in murders nationwide. Percent of criminals caught definitely fell when Boudin took office, but that’s because various aspects of the justice system were closed for COVID (I will grudgingly entertain speculation that a further decrease in arrest rates from 2020 to 2021 may have been a genuine Boudin effect). In the absence of any real way to judge his performance, I think San Fransicko’s points about Boudin are plausible, though speculative. Shoplifting This one is terrible. There’s a surprisingly spirited debate here (some of you may have already read Applied Divinity Studies’ article). The debate is: everyone on the ground in San Francisco - store owners, security guards, customers, random citizens - say that shoplifting has increased massively over the past decade. But statistics mostly say it hasn’t. Source here. This is shoplifting crimes per 100,000 people. Kern County is a deep red county in California (including Bakersfield) that is known for being tough on crime. Against this, seriously, everyone says that shoplifting has obviously increased. I had a patient who worked in shoplifting prevention, he told me - his psychiatrist! Who he had no reason to lie to! - that he was constantly stressed dealing with the shoplifting surge devastating the stores he covered. Here’s the San Francisco subreddit’s response to someone posting the data showing shoplifting hasn’t risen - it’s just a lot of people laughing hysterically. What’s going on? I was able to find a different set of statistics that does seem to show a longer-term increase in shoplifting (source): The very big spike at the end might be a change in reporting by one or two stores - you can find the argument here. But it does look like shoplifting went from about 125 incidents/month in the early 2010s to more like 250/month just before the pandemic. Why is this graph so different from the other one? It looks like the top one came from the Department of Justice, and the bottom one came from SFPD. I’m not sure why these report differently. When you multiply out by 800K people in SF, by 12 months/year, and 30ish days/month, the first graph corresponds to 4 shoplifting incidents per day, and the second to 6. As LouB’s analysis here points out, that seems suspiciously low for a city of 800,000 people where stores are constantly closing because of shoplifting. Maybe off by a factor of a few hundred from what we’d expect. LouB writes: The SFPD report only references shoplifting offenses that required SFPD officers to prepare an incident report. That means either the shoplifter fought security, committed additional crimes, or stole more than $950 worth of items. It’s not that SFPD’s report is erroneous, it’s just not a representative statistic. In a parallel statistic, SFPD only completes incident reports for traffic accidents when there is an injury. Therefore, thousands of noninjury accidents are handled civilly without SFPD reports the same way thousands of shoplifting offenses are handled without reports. An insurance company would not determine premium rates based solely on SFPD incident reports, nor should readers interpret SFPD shoplifting reports as anywhere near the total picture of the shoplifting epidemic in San Francisco. (this would also explain why one or two stores changing their reporting policy can produce a spike equal to everyone else in San Francisco combined) But comparing incident reports from 2010 to incident reports from 2020 should still be apples-to-apples, unless the likelihood of reporting any given incident changed in the meantime. Did it? This news article quotes a San Franciscan who says that when they try to report shoplifting incidents, the cops tell them not to because “it doesn’t make a difference”. If cops say that now more often than they used to, it would make all these statistics meaningless. (Applied Divinity Studies claims to have an argument that shows this can’t be true. It goes something like: if San Francisco was a better place to shoplift than its neighbors - eg Oakland - then shoplifters would leave Oakland to go to San Francisco, and we would see Oakland shoplifting rates falling. Oakland shoplifting rates are falling, but no more so than the rest of the state, so there can’t be increased tolerance for shoplifting in San Francisco. I find this dubious for many reasons. First of all, many of the same reasons shoplifting is up in San Francisco - like Prop 47 or soft-on-crime progressive policies - also apply to Oakland. Second, given that shoplifting fell massively everywhere because of the pandemic, it feels dubious to try to compare different cities; maybe one city had stricter pandemic lockdowns than others. Third, do criminals really shop around for friendly jurisdictions? If so, why are so many crimes like car break-ins, concentrated in “the bad part of town”? Why wouldn’t criminals leave the bad part of town for under-exploited areas with richer residents and less competition? Maybe criminals in fact aren’t very strategic or mobile? Maybe they don’t want to stand in the BART station and then take a half-hour train ride holding a bag of stolen goods?) Maybe a better argument against this being true is how stable the shoplifting rates have been over time. Wouldn’t it be weird if (let’s say) a tripling of the real shoplifting rates was matched by a third-ing of the reporting rates (rather than a halving or a quartering or whatever)? On the other hand, here’s Shellenberger with some helpful data: Some of this is probably because of Proposition 47, which made some forms of shoplifting punishable with citation rather than arrest (but wouldn’t that be a clear discontinuity rather than a gradual trend?) But overall it sure seems like shoplifting is being taken less seriously, which might encourage people to report less. Another statistic I see is that only 2.3% of shoplifting cases result in an arrest; I don’t know how this is different from the graph above with numbers in the 30s; maybe it involves different levels of what makes something a “case”. I accept that the data don’t consistently show a spike in shoplifting. But what’s the alternative? My patient who works in loss prevention in SF stores is lying to me? The nice elderly Chinese man who sold me my last pair of glasses and chatted to me about the rampant shoplifting in his mall was lying? The San Francisco police are lying? Walgreens pretends to be concerned about shoplifting as part of a dastardly plot to close a bunch of stores for no reason? Target and CVS pretend to care about shoplifting as part of a plot to restrict their stores’ opening hours for no reason? Every big store near me has suddenly gotten a security guard at the front as part of some corporate-sponsored jobs program? Maybe the conservative narrative that soft-on-crime San Francisco must be experiencing rising crime rates took on a life of its own. Maybe it infiltrated not just the usual suspects like the SF police unions, but even such supposedly-liberal bastions as the New York Times. Maybe lots of big corporations took advantage of the fake narrative to make unpopular business decisions they were planning on making anyway. And maybe ordinary San Franciscans, confronted with everyone telling them they were in a shoplifting epidemic, started paying more attention to security guards and petty criminals who had always been there, a sort of mass hallucination that gripped everyone in the city. I can’t rule this out. Americans thought crime was rising all throughout the early 2000s, when it was in fact way down. Or maybe some statistics that we already know are off by several orders of magnitude got off by an additional factor of two or so. I think this one is more likely, but I’m genuinely not sure. Other Crime From the Economist: The Center on Juvenile And Criminal Justice puts it even more starkly, arguing that “San Francisco’s ‘Crime Wave’ Is Just One Crime”: This are potentially susceptible to the same reporting bias as shoplifting. So what about homicide? Homicide is practically always reported and investigated, making it a gold standard in crime measurement. (source) Looks pretty good until 2019. I don’t expect to gain useful information post-2020; the pandemic and the post-George-Floyd murder surge will make it impossible to evaluate for local variation. What about compared to other places? For some reason this top 20 table fails to list Washington DC, which should be just before Atlanta. SF doesn’t make the top 20, although its neighbor Oakland does. Probably most murder variation in US cities is explained by percent African-American and maybe percent Borderer; with relatively few people in these groups SF was never in the running. I’m not sure if some abstracted version of the city with all demographic factors adjusted away would have an unusually high murder rate, but at that point it would be pretty distant from any interesting real-world question. You can see the leaderboard for other types of crime here; San Francisco is often in the top ten, but never the top three. As far as I can tell, San Francisco has seen a big spike in car breakins over the past few years, with no clear trend for other property crime, violent crime, or homicides. It’s not an outlier among American cities in any kind of crime. Conclusion of this section: San Fransicko’s specific claims are basically correct, but suggest a medium-term rise in SF crime which is mostly contradicted by the data. These show stable-to-decreasing murder, stable-to-decreasing violent and property crimes other than car break-ins, and large rises in car break-ins only. The data also show stable-to-decreasing shoplifting, but I’m not sure how much to trust them vs. common sense. Honestly, I’m pretty confused here and not sure what to think. Claim 7: Jim Jones (Of Kool-Aid Cult Fame) Used To Be The Chairman Of SF’s Housing Authority Okay, this isn’t really a statistical claim that I can research different perspectives on. Still, it’s so wacky that I couldn’t resist mentioning it in this review. Jim Jones, famous for killing everyone in his Guyana-based Jonestown cult with poisoned Kool-Aid, used to be the SF government’s top guy on homelessness. Shellenberger writes: Jones married and moved first to Northern California and then to San Francisco with his wife to start a church. He called it the People’s Temple. Jones believed he was the leader of a socialist revolution. He warned of nuclear war and claimed black people would be put in concentration camps. He became a hugely charismatic preacher among African Americans, the disaffiliated poor, and young transplants to the city looking for community. Scenes from the era show a remarkably large and diverse congregation smiling and singing. The People’s Temple grew and provided services. Jones cultivated two progressive San Francisco politicians, George Moscone and Willie Brown, and mobilized people to volunteer for their campaigns […] His son and a San Francisco historian believe he stole the mayoral election for Moscone in 1975. Historian David Talbot, founder of the progressive website Salon, points to evidence that Jones committed sufficient voter fraud to account for Moscone’s narrow 4,443-vote margin of victory. “We loaded up all thirteen of our buses with maybe seventy people on each bus, and we had those buses rolling nonstop up and down the coast into San Francisco the day before the election,” said Jones Jr. “Could we have been the force that tipped the election to Moscone? Absolutely! Slam dunk. He only won by four thousand votes.” When federal investigators looked into fraud claims three years later, they discovered that all of the records were missing from the city of San Francisco’s registrar of voters. Jones also boasted of providing Moscone with black women from his congregation for sex. One time Moscone, drunk and “accompanied by a young black woman whom the politician had kindly agreed to drive home,” crashed into another car. Another time, Moscone and Willie Brown “were with a black woman in an alley at two in the morning at some restaurant in North Beach,” said a local bar owner. State legislator “John Burton was part of that gang too. They were all using marijuana and cocaine.” Said Jones Jr., Moscone would “always be there at temple parties with a cocktail in his hand and doing some ass grabbing.” A Temple member overheard Jones speaking to Moscone the day after one of those parties saying, “I want to let you know that the young lady you went off with is underage,” adding, “Now don’t worry, Mayor, we’ll take care of you—because we know that you’ll take care of us.” Afterward, Moscone made Jones the chairman of the powerful San Francisco Housing Commission. Jones cultivated progressives with money and favors. He made large donations to the ACLU, the NAACP, and United Farm Workers. Jones and Moscone met privately with vice presidential candidate Walter Mondale on a campaign plane a few days before the 1976 presidential election, and Mondale praised People’s Temple shortly afterward. Jones met with First Lady Rosalynn Carter several times. Governor Jerry Brown praised Jones. Glide Memorial Church’s Rev. Cecil Williams loved Jones. There is a photo from 1977 of a smiling Williams awarding Jones the church’s “Martin Luther King, Jr. Award.” Jones used his perch as chairman of the Housing Commission to fight for housing for the poor. He tried to use eminent domain to acquire the International Hotel, a single resident occupancy hotel. After a court sided with the hotel’s owner, Jones mobilized seven thousand protesters to picket it. By mid-January 1977, the situation had become heated. There were rumors that protesters inside the building were armed with guns and Molotov cocktails. Jones lost the legal battle in 1977, and the tenants were evicted. But the drama was a publicity victory for Jones, which burnished his image as a white savior. A conservative member of the Board of Supervisors who was defeated in the mayoral election by Moscone accused the new mayor, the San Francisco Chronicle, and the rest of the city establishment of being blind to Jones’s extremism. “There’s no radical plot in San Francisco,” insisted Moscone, in response. “There’s no one I’ve appointed to any city position whom I regard as radical or extremist.” Willie Brown, a powerful state legislator from 1964 to 1995 before becoming mayor in 1996, “seemed oblivious to Jones’ hucksterism and demagoguery,” notes a historian. Brown was master of ceremonies at a dinner for Jones in the fall of 1976 attended by an adulatory crowd of the rich and powerful, including Governor Jerry Brown. “Let me present to you a combination of Martin King, Angela Davis, Albert Einstein . . . Chairman Mao,” he said, to loud applause. And yet Jones was contemptuous of Brown even as Brown did Jones more and more favors. Jones mocked Brown for his designer suits, sports cars, and women. Once, while Brown was addressing the congregation and Jones was seated onstage behind him, Jones flipped his middle finger up to mock him. San Francisco’s establishment stood by Jones even after a California magazine, New West, owned by Rupert Murdoch, published an exposé of Jones’s beatings of Temple members and financial abuses in August 1977. The article was written by a San Francisco Chronicle reporter and was meant for the Chronicle to publish. But the newspaper killed the story because it didn’t want to alienate Jones, whom it viewed as central to its plans to expand the Chronicle’s circulation in the heavily African American Fillmore District. Jones also managed to avoid investigation and prosecution in part by getting the district attorney to hire as deputy district attorney Jones’s longtime attorney and confidant. Progressives defended Jones against the New West article. At a rally in the summer of 1977, Willie Brown said, “When somebody like Jim Jones comes on the scene, that absolutely scares the hell out of most everybody occupying positions of power in the system.” Angela Davis sent a radio message broadcast over the cult’s compound, Jonestown, in Guyana. “I know you’re in a very difficult situation right now,” she said, “and there is a very profound conspiracy designed to destroy the contributions which you have made to the struggle.” After visiting Jonestown, the attorney to the Black Panthers said, “I have seen paradise.” Harvey Milk, too, was tarnished by his association with Jones. In the fall of 1977, Milk wrote to President Carter’s secretary of health, education, and welfare requesting that Social Security checks be sent to elderly Temple members in Guyana. “People’s Temple,” wrote Milk, has “established a beautiful retirement community in Guyana.” In truth, the cult was disintegrating. Jones separated families and lovers, pitted relatives against each other, and forced neighbors to inform on each other. Jones sent people who violated the rules to solitary confinement in “the Box,” an underground cubicle where people were held as prisoners for days on end. Others were drugged. Progressives who had spent thirty years fighting to close prisons and mental hospitals found themselves praising a man who had reproduced their worst practices. In November 1978 a Bay Area congressman flew to Guyana to investigate human rights violations at Jonestown with NBC News. Jones gave the delegation a formal reception at Jonestown. A Temple member surreptitiously passed a note to one of the delegation members, saying he and another member wanted to escape. They fled the next day after a Temple member tried to stab the congressman. Jones didn’t prevent them from leaving but then sent gunmen to fire machine guns at the delegation at the airport, killing the congressman and four others. A few hours later, 907 inhabitants of Jonestown drank Flavor Aid laced with cyanide and died. Two-thirds of the victims were African American and one-third were children. Jones had told them that if they didn’t drink it they would be killed by invading soldiers from a shadowy global military conspiracy intent on imposing fascism and torturing children. As people started crying in grief, Jones scolded them. “Stop these hysterics,” he said. “This is not the way for people who are socialists or communists to die.” Jones’s wife protested the murder of children and had to be forcibly restrained. “We didn’t commit suicide,” said Jones in a tape recording, “we committed an act of revolutionary suicide protesting the conditions of an inhumane world.” Few were as stained by Jonestown as Willie Brown and George Moscone. “Even as the bloated bodies of the dead were removed from the jungle and the wounded were airlifted by the U.S. Air Force to hospitals in the United States,” wrote a historian, “Brown said he had ‘no regrets’ over his association with Jones.” They repeatedly disavowed responsibility. Said Moscone, “it’s clear that if there was a sinister plan, then we were taken in. But I’m not taking any responsibility. It’s not mine to shoulder.” This is Shellenberger at his best: telling us crazy stories from the recesses of San Francisco history, maybe kind of spinning the narration in a way that makes all progressives seem guilty by association, but with the tale itself so gripping that it’s hard to be mad. And Jones wasn’t alone. This was the golden age of San Francisco cults, when (Shellenberger tells us) “more than half of all high school students in the San Francisco Bay Area reported at least one recruiting attempt by a cult member, and 40 percent reported at least three contacts.” This chapter of SF history came to an end in 1978, when Dan White, who had just resigned from San Francisco’s Board Of Supervisors (ie City Council) entered City Hall through a window and assassinated Mayor Moscone and fellow Supervisor Harvey Milk, then successfully got charges reduced to manslaughter through a legal manuever that has gone down in history as “the Twinkie Defense” (realistically the defense was that he was depressed, but reporters seized on a comment that implied it was because he ate too many Twinkies). Everything about 1970s San Francisco was like this. With the Mayor and his right-hand-man both dead, San Francisco leadership ended up in the hands of previously second-tier politician Dianne Feinstein. Feinstein was what passed for a moderate in 1970s SF (which meant she had been targeted for assassination by various left-wing groups - she survived when a bomb left on her windowsill failed to explode). In Shellenberger’s telling, she managed to clean up some of the mess and restore a semblance of normalcy. San Francisco never forgave her. Moscone - voting fraud committer, underage sex enjoyer, and Jim Jones’ bff - is beloved as a martyr in today’s SF, but (the book points out) Feinstein is so loathed that in 2021 the Board of Education voted to rename Dianne Feinstein Elementary School. The Moscone Center is 2 million square feet and can fit about 10,000 people. Not to be confused with the Moscone Recreation Center, Moscone Station, or Moscone Elementary School. Meanwhile, all Dianne Feinstein got was one lousy elementary school and the Tithonus package of eternal life without eternal youth. Claim 8: The Intolerant Left Shuts Down Debate On These Issues Another one that’s probably hard to do a randomized controlled trial on. You could probably predict that this one was coming - it’s a necessary narrative beat in this genre of book. I think this beat is good. My impression is that people who aren’t themselves public figures disagreeing with left-wing ideas still don’t understand how scary it is and how much hate you get. Maybe now that 2/3s of every political essay written over the past five years is about this topic, people will finally get it through their thick skulls that it exists and is bad. I would also note that “traumatizing the sorts of people who write popular books about politics, in a such a way that they feel compelled as a sort of self-therapy to write page after page telling readers how angry they should be at you and your whole coalition” isn’t great political praxis. I would like people to figure this out and stop doing it. Anyway, Shellenberger is doing his part in this effort: In 2001, the San Francisco Coalition on Homelessness wheat-pasted posters of a fake front-page San Francisco Chronicle across town. Just beneath the masthead a large headline read “Fuck the Homeless!” right above a picture of San Francisco mayor Willie Brown laughing. Below his photo was the headline “Save the Tourists.” Progressives level the same charges at people thirty years later. “Because of some of the stuff I say,” said a community activist in Seattle’s historically black Capitol Hill neighborhood, “people say, ‘Oh, she’s not for them.’ But I have a heart for homeless and mentally ill. Most of my family works with the mentally ill.” Noted a Chronicle journalist in 2017, “Inevitably, homeless advocates and others will say, ‘You’re not compassionate,’” in response to stories about homeless encampments. “They called me a racist,” said Tom. “They accused me, a guy who used to be homeless, of demonizing the homeless, because I’m asking for accountability.” I found myself similarly accused. In 2019, after I published an article for Forbes about the homeless crisis, a progressive homeless activist accused me on Twitter of having written my article to “make money off of a fear tactic” of “fueling hatred [and] even increasing violence against homeless people.” After I asked the former San Francisco supervisor for the Tenderloin neighborhood, former mayoral candidate Jane Kim, how such a progressive city ended up with so much suffering, she said, “My concern, Michael, just to be very honest, is that when that kind of messaging goes out, violence against people who are unhoused goes up.” […] I soon discovered in my research that I was hardly the first person that progressive elected officials and homelessness advocates had accused of fomenting violence against unhoused people. Many others had been criticized for far worse over the years, including San Francisco’s highest elected officials. “The criticism [by progressive homelessness advocates] was heavy, political and personal,” wrote former mayor Willie Brown in his 2008 memoir. “People accused me of abandoning the problem when I was working daily to try and get a solution going. It was brutal. . . . I had become demonized, and my own efforts belittled.” It is notable that the result of such personal attacks is to frighten off people seeking to change, and perhaps improve, the situation. “The problem” of homelessness, concluded Mayor Brown within nine months of entering office, “may not be solvable.” And [Quoting Chris Rufo]. “The chief of psychiatry in a public hospital system in one of the largest California cities told me, ‘I know for a fact, and all of my colleagues know, that what we actually need to deal with the problem in the biggest cities in California is long-term residential secure psychiatric care. But I can’t say that publicly because I would be disemboweled by the activist left. My job would be in jeopardy. My reputation would be in jeopardy. My whole life would get turned upside down for even broaching the subject of expanding secure mental health facilities and compulsory mental health treatment.’ And I said, ‘So what’s the solution?’ and this person said, ‘We muddle through.’” And: In San Francisco, radical left activists protested [African-American] Mayor London Breed in front of her home. Breed said the protesters were “all white people. But that didn’t bother me as much as the taunting of me coming outside with firework torches in their hands looking like what used to happen when the KKK would show up to black people’s houses to burn their houses down.” While I was reading the book, I came across this tweet, which suggests that being unimpressed with SF’s lefty homeless activist scene is not limited to Michael Shellenberger: Claim 9: European Cities Like Amsterdam Successfully Solved Their Own Drug And Homelessness Problems By Doing The Opposite Of SF Shellenberger bases his plan to solve these problems on ideas that he says were pioneered in Amsterdam and spread to other European cities. In the 1980s, Amsterdam had the kinds of problems San Francisco deals with now: open-air drug markets, overdose deaths, homelessness, and crime. But in the 90s, they admitted they had a problem and took decisive action: What’s the secret?” I asked him. “Amsterdam has decriminalized marijuana and many other drugs but I haven’t seen any homeless. What is San Francisco doing wrong?” Rene said that in the 1980s, the Zeedijk neighborhood in Amsterdam was a lot like the Tenderloin [the worst part of San Francisco] today. There was open-air drug use, particularly of heroin, and needles strewn about, as well as crime. People started to flee the neighborhood, worsening its slum conditions. Homeless people squatted in abandoned buildings. “We had ghettos where it was not safe to go,” said Rene, who started working in the neighborhood as a nurse in 1985. It was considered a “no go” zone. “We had a lot of people from abroad who came to Amsterdam because our heroin was so good. But our heroin was so good that they died from it.” At first the city tried a “helping approach” exclusively, offering addicts clean needles, methadone, and other forms of help without any law enforcement, but it didn’t work. “In the eighties we just wanted to help people,” said Rene. “We started with methadone programs and medical treatment. We did a lot of work without much of a carrot and a stick. It was really a disappointment. They just used the methadone to stay addicted. They dealt drugs and committed other crimes. They lied and cheated about it. We were just supporting a different kind of market. We had to learn the hard way [...] The Amsterdam City Council asked the Amsterdam Municipal Health Service to develop a strategy to deal with “unmotivated drug users”...The police broke up the open-air drug scene and health workers were on hand to offer methadone, treatment, and shelter. The police broke up gatherings of more than four or five users, but did not treat personal and private use as a crime. Officers ticketed violators, and if users did not pay their fines, which was frequent, the courts ordered arrests, and sentenced individuals to follow a treatment plan or face incarceration. “For every individual homeless person, we make a plan,” said Rene. “We made tens of thousands of those plans.” Plans are overseen by a caseworker and a team that may include a psychiatrist, shelter provider, service provider, judge, employer, parole officer, and police officer. “You need people in the police and health department working together,” he said. What Amsterdam did was the same as other major European cities. Lisbon, Frankfurt, Vienna, and Zurich all dealt with their open-air drug markets, using a combination of law enforcement and social services. Crucially, Amsterdam and other European cities prevented services from being concentrated in a single neighborhood, since their concentration often enables an open-air drug scene to thrive [...] The efforts worked. “We had several thousand people who were addicted to heroin in the eighties and nineties,” said Rene. “Many died. Today we have four or five hundred people addicted to methadone. And we have about 120 in Amsterdam who we supply heroin to on a medical basis because methadone doesn’t work for them. They have to use heroin.” The Amsterdam strategy goes something like: Break up open-air drug markets and anywhere that more than 4-5 drug users are congregating. Yes, people can just use their drugs in private, but this is legitimately better. Open-air markets normalize drugs with their blatantness, and make it hard to quit for the same reason it’s hard to diet if your partner leaves boxes of donuts out in the house every day.
Inline links: Ed West, Public Policy Institute, UCI criminologists, Applied Divinity Studies’ article, https://substackcdn.com/image/fetch/$s_!aTNC!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2Fa27aeb21-ed87-4e67-b82c-b3ceecee7082_500x238.png, here, Here’s the San Francisco subreddit’s response, https://substackcdn.com/image/fetch/$s_!_NL6!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2Fcf7dc478-45d3-487d-8c29-8bc7cdf182dd_2400x1500.png, LouB’s analysis here, This news article, only 2.3% of shoplifting cases result in an arrest, New York Times, the Economist, https://substackcdn.com/image/fetch/$s_!58I3!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2Fc63dc7bc-1f8e-49fd-9c68-61c85278d69e_608x662.png, San Francisco’s ‘Crime Wave’ Is Just One Crime, https://substackcdn.com/image/fetch/$s_!h17s!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F956c0917-2a9b-4ff7-a08e-6aee5030583a_590x376.png, https://substackcdn.com/image/fetch/$s_!TkFS!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F5c5faa01-ac22-48a2-96fe-47efb6f52514_616x334.png, source, https://substackcdn.com/image/fetch/$s_!Bg2w!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F18e49c63-16ba-4878-96e6-aec12d7c5953_481x667.png, percent African-American, percent Borderer, here, the Twinkie Defense, https://substackcdn.com/image/fetch/$s_!8wK3!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F683b9754-f663-47ad-88f5-aa99bc208ec8_1401x622.jpeg, https://twitter.com/weheartprez/status/1526983899309432832
The very big spike at the end might be a change in reporting by one or two stores - you can find the argument here. But it does look like shoplifting went from about 125 incidents/month in the early 2010s to more like 250/month just before the pandemic. Why is this graph so different from the other one? It looks like the top one came from the Department of Justice, and the bottom one came from SFPD. I’m not sure why these report differently. When you multiply out by 800K people in SF, by 12 months/year, and 30ish days/month, the first graph corresponds to 4 shoplifting incidents per day, and the second to 6. As LouB’s analysis here points out, that seems suspiciously low for a city of 800,000 people where stores are constantly closing because of shoplifting. Maybe off by a factor of a few hundred from what we’d expect. LouB writes: The SFPD report only references shoplifting offenses that required SFPD officers to prepare an incident report. That means either the shoplifter fought security, committed additional crimes, or stole more than $950 worth of items. It’s not that SFPD’s report is erroneous, it’s just not a representative statistic. In a parallel statistic, SFPD only completes incident reports for traffic accidents when there is an injury. Therefore, thousands of noninjury accidents are handled civilly without SFPD reports the same way thousands of shoplifting offenses are handled without reports. An insurance company would not determine premium rates based solely on SFPD incident reports, nor should readers interpret SFPD shoplifting reports as anywhere near the total picture of the shoplifting epidemic in San Francisco. (this would also explain why one or two stores changing their reporting policy can produce a spike equal to everyone else in San Francisco combined) But comparing incident reports from 2010 to incident reports from 2020 should still be apples-to-apples, unless the likelihood of reporting any given incident changed in the meantime. Did it? This news article quotes a San Franciscan who says that when they try to report shoplifting incidents, the cops tell them not to because “it doesn’t make a difference”. If cops say that now more often than they used to, it would make all these statistics meaningless. (Applied Divinity Studies claims to have an argument that shows this can’t be true. It goes something like: if San Francisco was a better place to shoplift than its neighbors - eg Oakland - then shoplifters would leave Oakland to go to San Francisco, and we would see Oakland shoplifting rates falling. Oakland shoplifting rates are falling, but no more so than the rest of the state, so there can’t be increased tolerance for shoplifting in San Francisco. I find this dubious for many reasons. First of all, many of the same reasons shoplifting is up in San Francisco - like Prop 47 or soft-on-crime progressive policies - also apply to Oakland. Second, given that shoplifting fell massively everywhere because of the pandemic, it feels dubious to try to compare different cities; maybe one city had stricter pandemic lockdowns than others. Third, do criminals really shop around for friendly jurisdictions? If so, why are so many crimes like car break-ins, concentrated in “the bad part of town”? Why wouldn’t criminals leave the bad part of town for under-exploited areas with richer residents and less competition? Maybe criminals in fact aren’t very strategic or mobile? Maybe they don’t want to stand in the BART station and then take a half-hour train ride holding a bag of stolen goods?) Maybe a better argument against this being true is how stable the shoplifting rates have been over time. Wouldn’t it be weird if (let’s say) a tripling of the real shoplifting rates was matched by a third-ing of the reporting rates (rather than a halving or a quartering or whatever)? On the other hand, here’s Shellenberger with some helpful data: Some of this is probably because of Proposition 47, which made some forms of shoplifting punishable with citation rather than arrest (but wouldn’t that be a clear discontinuity rather than a gradual trend?) But overall it sure seems like shoplifting is being taken less seriously, which might encourage people to report less. Another statistic I see is that only 2.3% of shoplifting cases result in an arrest; I don’t know how this is different from the graph above with numbers in the 30s; maybe it involves different levels of what makes something a “case”. I accept that the data don’t consistently show a spike in shoplifting. But what’s the alternative? My patient who works in loss prevention in SF stores is lying to me? The nice elderly Chinese man who sold me my last pair of glasses and chatted to me about the rampant shoplifting in his mall was lying? The San Francisco police are lying? Walgreens pretends to be concerned about shoplifting as part of a dastardly plot to close a bunch of stores for no reason? Target and CVS pretend to care about shoplifting as part of a plot to restrict their stores’ opening hours for no reason? Every big store near me has suddenly gotten a security guard at the front as part of some corporate-sponsored jobs program? Maybe the conservative narrative that soft-on-crime San Francisco must be experiencing rising crime rates took on a life of its own. Maybe it infiltrated not just the usual suspects like the SF police unions, but even such supposedly-liberal bastions as the New York Times. Maybe lots of big corporations took advantage of the fake narrative to make unpopular business decisions they were planning on making anyway. And maybe ordinary San Franciscans, confronted with everyone telling them they were in a shoplifting epidemic, started paying more attention to security guards and petty criminals who had always been there, a sort of mass hallucination that gripped everyone in the city. I can’t rule this out. Americans thought crime was rising all throughout the early 2000s, when it was in fact way down. Or maybe some statistics that we already know are off by several orders of magnitude got off by an additional factor of two or so. I think this one is more likely, but I’m genuinely not sure. Other Crime From the Economist: The Center on Juvenile And Criminal Justice puts it even more starkly, arguing that “San Francisco’s ‘Crime Wave’ Is Just One Crime”: This are potentially susceptible to the same reporting bias as shoplifting. So what about homicide? Homicide is practically always reported and investigated, making it a gold standard in crime measurement. (source) Looks pretty good until 2019. I don’t expect to gain useful information post-2020; the pandemic and the post-George-Floyd murder surge will make it impossible to evaluate for local variation. What about compared to other places? For some reason this top 20 table fails to list Washington DC, which should be just before Atlanta. SF doesn’t make the top 20, although its neighbor Oakland does. Probably most murder variation in US cities is explained by percent African-American and maybe percent Borderer; with relatively few people in these groups SF was never in the running. I’m not sure if some abstracted version of the city with all demographic factors adjusted away would have an unusually high murder rate, but at that point it would be pretty distant from any interesting real-world question. You can see the leaderboard for other types of crime here; San Francisco is often in the top ten, but never the top three. As far as I can tell, San Francisco has seen a big spike in car breakins over the past few years, with no clear trend for other property crime, violent crime, or homicides. It’s not an outlier among American cities in any kind of crime. Conclusion of this section: San Fransicko’s specific claims are basically correct, but suggest a medium-term rise in SF crime which is mostly contradicted by the data. These show stable-to-decreasing murder, stable-to-decreasing violent and property crimes other than car break-ins, and large rises in car break-ins only. The data also show stable-to-decreasing shoplifting, but I’m not sure how much to trust them vs. common sense. Honestly, I’m pretty confused here and not sure what to think. Claim 7: Jim Jones (Of Kool-Aid Cult Fame) Used To Be The Chairman Of SF’s Housing Authority Okay, this isn’t really a statistical claim that I can research different perspectives on. Still, it’s so wacky that I couldn’t resist mentioning it in this review. Jim Jones, famous for killing everyone in his Guyana-based Jonestown cult with poisoned Kool-Aid, used to be the SF government’s top guy on homelessness. Shellenberger writes: Jones married and moved first to Northern California and then to San Francisco with his wife to start a church. He called it the People’s Temple. Jones believed he was the leader of a socialist revolution. He warned of nuclear war and claimed black people would be put in concentration camps. He became a hugely charismatic preacher among African Americans, the disaffiliated poor, and young transplants to the city looking for community. Scenes from the era show a remarkably large and diverse congregation smiling and singing. The People’s Temple grew and provided services. Jones cultivated two progressive San Francisco politicians, George Moscone and Willie Brown, and mobilized people to volunteer for their campaigns […] His son and a San Francisco historian believe he stole the mayoral election for Moscone in 1975. Historian David Talbot, founder of the progressive website Salon, points to evidence that Jones committed sufficient voter fraud to account for Moscone’s narrow 4,443-vote margin of victory. “We loaded up all thirteen of our buses with maybe seventy people on each bus, and we had those buses rolling nonstop up and down the coast into San Francisco the day before the election,” said Jones Jr. “Could we have been the force that tipped the election to Moscone? Absolutely! Slam dunk. He only won by four thousand votes.” When federal investigators looked into fraud claims three years later, they discovered that all of the records were missing from the city of San Francisco’s registrar of voters. Jones also boasted of providing Moscone with black women from his congregation for sex. One time Moscone, drunk and “accompanied by a young black woman whom the politician had kindly agreed to drive home,” crashed into another car. Another time, Moscone and Willie Brown “were with a black woman in an alley at two in the morning at some restaurant in North Beach,” said a local bar owner. State legislator “John Burton was part of that gang too. They were all using marijuana and cocaine.” Said Jones Jr., Moscone would “always be there at temple parties with a cocktail in his hand and doing some ass grabbing.” A Temple member overheard Jones speaking to Moscone the day after one of those parties saying, “I want to let you know that the young lady you went off with is underage,” adding, “Now don’t worry, Mayor, we’ll take care of you—because we know that you’ll take care of us.” Afterward, Moscone made Jones the chairman of the powerful San Francisco Housing Commission. Jones cultivated progressives with money and favors. He made large donations to the ACLU, the NAACP, and United Farm Workers. Jones and Moscone met privately with vice presidential candidate Walter Mondale on a campaign plane a few days before the 1976 presidential election, and Mondale praised People’s Temple shortly afterward. Jones met with First Lady Rosalynn Carter several times. Governor Jerry Brown praised Jones. Glide Memorial Church’s Rev. Cecil Williams loved Jones. There is a photo from 1977 of a smiling Williams awarding Jones the church’s “Martin Luther King, Jr. Award.” Jones used his perch as chairman of the Housing Commission to fight for housing for the poor. He tried to use eminent domain to acquire the International Hotel, a single resident occupancy hotel. After a court sided with the hotel’s owner, Jones mobilized seven thousand protesters to picket it. By mid-January 1977, the situation had become heated. There were rumors that protesters inside the building were armed with guns and Molotov cocktails. Jones lost the legal battle in 1977, and the tenants were evicted. But the drama was a publicity victory for Jones, which burnished his image as a white savior. A conservative member of the Board of Supervisors who was defeated in the mayoral election by Moscone accused the new mayor, the San Francisco Chronicle, and the rest of the city establishment of being blind to Jones’s extremism. “There’s no radical plot in San Francisco,” insisted Moscone, in response. “There’s no one I’ve appointed to any city position whom I regard as radical or extremist.” Willie Brown, a powerful state legislator from 1964 to 1995 before becoming mayor in 1996, “seemed oblivious to Jones’ hucksterism and demagoguery,” notes a historian. Brown was master of ceremonies at a dinner for Jones in the fall of 1976 attended by an adulatory crowd of the rich and powerful, including Governor Jerry Brown. “Let me present to you a combination of Martin King, Angela Davis, Albert Einstein . . . Chairman Mao,” he said, to loud applause. And yet Jones was contemptuous of Brown even as Brown did Jones more and more favors. Jones mocked Brown for his designer suits, sports cars, and women. Once, while Brown was addressing the congregation and Jones was seated onstage behind him, Jones flipped his middle finger up to mock him. San Francisco’s establishment stood by Jones even after a California magazine, New West, owned by Rupert Murdoch, published an exposé of Jones’s beatings of Temple members and financial abuses in August 1977. The article was written by a San Francisco Chronicle reporter and was meant for the Chronicle to publish. But the newspaper killed the story because it didn’t want to alienate Jones, whom it viewed as central to its plans to expand the Chronicle’s circulation in the heavily African American Fillmore District. Jones also managed to avoid investigation and prosecution in part by getting the district attorney to hire as deputy district attorney Jones’s longtime attorney and confidant. Progressives defended Jones against the New West article. At a rally in the summer of 1977, Willie Brown said, “When somebody like Jim Jones comes on the scene, that absolutely scares the hell out of most everybody occupying positions of power in the system.” Angela Davis sent a radio message broadcast over the cult’s compound, Jonestown, in Guyana. “I know you’re in a very difficult situation right now,” she said, “and there is a very profound conspiracy designed to destroy the contributions which you have made to the struggle.” After visiting Jonestown, the attorney to the Black Panthers said, “I have seen paradise.” Harvey Milk, too, was tarnished by his association with Jones. In the fall of 1977, Milk wrote to President Carter’s secretary of health, education, and welfare requesting that Social Security checks be sent to elderly Temple members in Guyana. “People’s Temple,” wrote Milk, has “established a beautiful retirement community in Guyana.” In truth, the cult was disintegrating. Jones separated families and lovers, pitted relatives against each other, and forced neighbors to inform on each other. Jones sent people who violated the rules to solitary confinement in “the Box,” an underground cubicle where people were held as prisoners for days on end. Others were drugged. Progressives who had spent thirty years fighting to close prisons and mental hospitals found themselves praising a man who had reproduced their worst practices. In November 1978 a Bay Area congressman flew to Guyana to investigate human rights violations at Jonestown with NBC News. Jones gave the delegation a formal reception at Jonestown. A Temple member surreptitiously passed a note to one of the delegation members, saying he and another member wanted to escape. They fled the next day after a Temple member tried to stab the congressman. Jones didn’t prevent them from leaving but then sent gunmen to fire machine guns at the delegation at the airport, killing the congressman and four others. A few hours later, 907 inhabitants of Jonestown drank Flavor Aid laced with cyanide and died. Two-thirds of the victims were African American and one-third were children. Jones had told them that if they didn’t drink it they would be killed by invading soldiers from a shadowy global military conspiracy intent on imposing fascism and torturing children. As people started crying in grief, Jones scolded them. “Stop these hysterics,” he said. “This is not the way for people who are socialists or communists to die.” Jones’s wife protested the murder of children and had to be forcibly restrained. “We didn’t commit suicide,” said Jones in a tape recording, “we committed an act of revolutionary suicide protesting the conditions of an inhumane world.” Few were as stained by Jonestown as Willie Brown and George Moscone. “Even as the bloated bodies of the dead were removed from the jungle and the wounded were airlifted by the U.S. Air Force to hospitals in the United States,” wrote a historian, “Brown said he had ‘no regrets’ over his association with Jones.” They repeatedly disavowed responsibility. Said Moscone, “it’s clear that if there was a sinister plan, then we were taken in. But I’m not taking any responsibility. It’s not mine to shoulder.” This is Shellenberger at his best: telling us crazy stories from the recesses of San Francisco history, maybe kind of spinning the narration in a way that makes all progressives seem guilty by association, but with the tale itself so gripping that it’s hard to be mad. And Jones wasn’t alone. This was the golden age of San Francisco cults, when (Shellenberger tells us) “more than half of all high school students in the San Francisco Bay Area reported at least one recruiting attempt by a cult member, and 40 percent reported at least three contacts.” This chapter of SF history came to an end in 1978, when Dan White, who had just resigned from San Francisco’s Board Of Supervisors (ie City Council) entered City Hall through a window and assassinated Mayor Moscone and fellow Supervisor Harvey Milk, then successfully got charges reduced to manslaughter through a legal manuever that has gone down in history as “the Twinkie Defense” (realistically the defense was that he was depressed, but reporters seized on a comment that implied it was because he ate too many Twinkies). Everything about 1970s San Francisco was like this. With the Mayor and his right-hand-man both dead, San Francisco leadership ended up in the hands of previously second-tier politician Dianne Feinstein. Feinstein was what passed for a moderate in 1970s SF (which meant she had been targeted for assassination by various left-wing groups - she survived when a bomb left on her windowsill failed to explode). In Shellenberger’s telling, she managed to clean up some of the mess and restore a semblance of normalcy. San Francisco never forgave her. Moscone - voting fraud committer, underage sex enjoyer, and Jim Jones’ bff - is beloved as a martyr in today’s SF, but (the book points out) Feinstein is so loathed that in 2021 the Board of Education voted to rename Dianne Feinstein Elementary School. The Moscone Center is 2 million square feet and can fit about 10,000 people. Not to be confused with the Moscone Recreation Center, Moscone Station, or Moscone Elementary School. Meanwhile, all Dianne Feinstein got was one lousy elementary school and the Tithonus package of eternal life without eternal youth. Claim 8: The Intolerant Left Shuts Down Debate On These Issues Another one that’s probably hard to do a randomized controlled trial on. You could probably predict that this one was coming - it’s a necessary narrative beat in this genre of book. I think this beat is good. My impression is that people who aren’t themselves public figures disagreeing with left-wing ideas still don’t understand how scary it is and how much hate you get. Maybe now that 2/3s of every political essay written over the past five years is about this topic, people will finally get it through their thick skulls that it exists and is bad. I would also note that “traumatizing the sorts of people who write popular books about politics, in a such a way that they feel compelled as a sort of self-therapy to write page after page telling readers how angry they should be at you and your whole coalition” isn’t great political praxis. I would like people to figure this out and stop doing it. Anyway, Shellenberger is doing his part in this effort: In 2001, the San Francisco Coalition on Homelessness wheat-pasted posters of a fake front-page San Francisco Chronicle across town. Just beneath the masthead a large headline read “Fuck the Homeless!” right above a picture of San Francisco mayor Willie Brown laughing. Below his photo was the headline “Save the Tourists.” Progressives level the same charges at people thirty years later. “Because of some of the stuff I say,” said a community activist in Seattle’s historically black Capitol Hill neighborhood, “people say, ‘Oh, she’s not for them.’ But I have a heart for homeless and mentally ill. Most of my family works with the mentally ill.” Noted a Chronicle journalist in 2017, “Inevitably, homeless advocates and others will say, ‘You’re not compassionate,’” in response to stories about homeless encampments. “They called me a racist,” said Tom. “They accused me, a guy who used to be homeless, of demonizing the homeless, because I’m asking for accountability.” I found myself similarly accused. In 2019, after I published an article for Forbes about the homeless crisis, a progressive homeless activist accused me on Twitter of having written my article to “make money off of a fear tactic” of “fueling hatred [and] even increasing violence against homeless people.” After I asked the former San Francisco supervisor for the Tenderloin neighborhood, former mayoral candidate Jane Kim, how such a progressive city ended up with so much suffering, she said, “My concern, Michael, just to be very honest, is that when that kind of messaging goes out, violence against people who are unhoused goes up.” […] I soon discovered in my research that I was hardly the first person that progressive elected officials and homelessness advocates had accused of fomenting violence against unhoused people. Many others had been criticized for far worse over the years, including San Francisco’s highest elected officials. “The criticism [by progressive homelessness advocates] was heavy, political and personal,” wrote former mayor Willie Brown in his 2008 memoir. “People accused me of abandoning the problem when I was working daily to try and get a solution going. It was brutal. . . . I had become demonized, and my own efforts belittled.” It is notable that the result of such personal attacks is to frighten off people seeking to change, and perhaps improve, the situation. “The problem” of homelessness, concluded Mayor Brown within nine months of entering office, “may not be solvable.” And [Quoting Chris Rufo]. “The chief of psychiatry in a public hospital system in one of the largest California cities told me, ‘I know for a fact, and all of my colleagues know, that what we actually need to deal with the problem in the biggest cities in California is long-term residential secure psychiatric care. But I can’t say that publicly because I would be disemboweled by the activist left. My job would be in jeopardy. My reputation would be in jeopardy. My whole life would get turned upside down for even broaching the subject of expanding secure mental health facilities and compulsory mental health treatment.’ And I said, ‘So what’s the solution?’ and this person said, ‘We muddle through.’” And: In San Francisco, radical left activists protested [African-American] Mayor London Breed in front of her home. Breed said the protesters were “all white people. But that didn’t bother me as much as the taunting of me coming outside with firework torches in their hands looking like what used to happen when the KKK would show up to black people’s houses to burn their houses down.” While I was reading the book, I came across this tweet, which suggests that being unimpressed with SF’s lefty homeless activist scene is not limited to Michael Shellenberger: Claim 9: European Cities Like Amsterdam Successfully Solved Their Own Drug And Homelessness Problems By Doing The Opposite Of SF Shellenberger bases his plan to solve these problems on ideas that he says were pioneered in Amsterdam and spread to other European cities. In the 1980s, Amsterdam had the kinds of problems San Francisco deals with now: open-air drug markets, overdose deaths, homelessness, and crime. But in the 90s, they admitted they had a problem and took decisive action: What’s the secret?” I asked him. “Amsterdam has decriminalized marijuana and many other drugs but I haven’t seen any homeless. What is San Francisco doing wrong?” Rene said that in the 1980s, the Zeedijk neighborhood in Amsterdam was a lot like the Tenderloin [the worst part of San Francisco] today. There was open-air drug use, particularly of heroin, and needles strewn about, as well as crime. People started to flee the neighborhood, worsening its slum conditions. Homeless people squatted in abandoned buildings. “We had ghettos where it was not safe to go,” said Rene, who started working in the neighborhood as a nurse in 1985. It was considered a “no go” zone. “We had a lot of people from abroad who came to Amsterdam because our heroin was so good. But our heroin was so good that they died from it.” At first the city tried a “helping approach” exclusively, offering addicts clean needles, methadone, and other forms of help without any law enforcement, but it didn’t work. “In the eighties we just wanted to help people,” said Rene. “We started with methadone programs and medical treatment. We did a lot of work without much of a carrot and a stick. It was really a disappointment. They just used the methadone to stay addicted. They dealt drugs and committed other crimes. They lied and cheated about it. We were just supporting a different kind of market. We had to learn the hard way [...] The Amsterdam City Council asked the Amsterdam Municipal Health Service to develop a strategy to deal with “unmotivated drug users”...The police broke up the open-air drug scene and health workers were on hand to offer methadone, treatment, and shelter. The police broke up gatherings of more than four or five users, but did not treat personal and private use as a crime. Officers ticketed violators, and if users did not pay their fines, which was frequent, the courts ordered arrests, and sentenced individuals to follow a treatment plan or face incarceration. “For every individual homeless person, we make a plan,” said Rene. “We made tens of thousands of those plans.” Plans are overseen by a caseworker and a team that may include a psychiatrist, shelter provider, service provider, judge, employer, parole officer, and police officer. “You need people in the police and health department working together,” he said. What Amsterdam did was the same as other major European cities. Lisbon, Frankfurt, Vienna, and Zurich all dealt with their open-air drug markets, using a combination of law enforcement and social services. Crucially, Amsterdam and other European cities prevented services from being concentrated in a single neighborhood, since their concentration often enables an open-air drug scene to thrive [...] The efforts worked. “We had several thousand people who were addicted to heroin in the eighties and nineties,” said Rene. “Many died. Today we have four or five hundred people addicted to methadone. And we have about 120 in Amsterdam who we supply heroin to on a medical basis because methadone doesn’t work for them. They have to use heroin.” The Amsterdam strategy goes something like: Break up open-air drug markets and anywhere that more than 4-5 drug users are congregating. Yes, people can just use their drugs in private, but this is legitimately better. Open-air markets normalize drugs with their blatantness, and make it hard to quit for the same reason it’s hard to diet if your partner leaves boxes of donuts out in the house every day.
Inline links: here, LouB’s analysis here, This news article, only 2.3% of shoplifting cases result in an arrest, New York Times, the Economist, https://substackcdn.com/image/fetch/$s_!58I3!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2Fc63dc7bc-1f8e-49fd-9c68-61c85278d69e_608x662.png, San Francisco’s ‘Crime Wave’ Is Just One Crime, https://substackcdn.com/image/fetch/$s_!h17s!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F956c0917-2a9b-4ff7-a08e-6aee5030583a_590x376.png, https://substackcdn.com/image/fetch/$s_!TkFS!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F5c5faa01-ac22-48a2-96fe-47efb6f52514_616x334.png, source, https://substackcdn.com/image/fetch/$s_!Bg2w!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F18e49c63-16ba-4878-96e6-aec12d7c5953_481x667.png, percent African-American, percent Borderer, here, the Twinkie Defense, https://substackcdn.com/image/fetch/$s_!8wK3!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F683b9754-f663-47ad-88f5-aa99bc208ec8_1401x622.jpeg, https://twitter.com/weheartprez/status/1526983899309432832
Highlights From The Comments On San Fransicko
June 29, 2022 · Original source
I can tell you [the shoplifting situation is] actually very simple. Almost all data on property crimes is garbage. Most people do not reliably report property crimes of any kind, if you look at the National Crime Victimization Survey you see only about 30% of larceny is ever reported. Shoplifting in particular is almost never reported in large cities, retail workers do not care. They don’t get paid to care, they don’t need a police report for insurance, it takes hours to get a police response, and nothing happens to shoplifters in any large progressive city anyway. I used to ask retail employees in my beat, they would always tell me about rampant shoplifting they simply didn’t bother to report. Changes in reporting caused by Prop 47, COVID and other random factors like police response time will always swamp any actual change in crime. Property crime statistics are worthless. People should believe their own eyes.
The Case Against California Proposition 36
October 29, 2024 · Original source
In 2011, the Supreme Court ruled that California prisons were so overcrowded that their conditions violated the 8th Amendment ban on cruel and unusual punishment. That year, the state assembly passed a package of reforms called "realignment," which shifted supervision of low-level offenders from the state to the counties. Then, in 2014, Californians voted for Proposition 47, which reduced some felony crimes to misdemeanors – theft of goods valued at under $950 and simple drug possession – and made people in prison for those crimes eligible for resentencing. Together, realignment and Prop 47 brought down California’s prison and jail population by 55,000.
The campaign for Prop 36 is based on the premise that Prop 47 failed, leading to increased drug use and retail theft (but don’t trust me – it says so in the text of the measure). 36 would repeal some parts of 47, add some additional sentencing increases, and leave some elements in place (the LA Times has a good breakdown of the changes here).
Inline links: text, here
Drug overdoses in California started to spike dramatically starting around about 2017, a few years after Prop 47 was passed.
psychoanalysis3 mentions across 3 issues

psychoanalysis is a recurring concept in the Astral Codex Ten archive, appearing 3 times across 3 issues between April 20, 2022 and June 26, 2025. The archive places it in contexts such as "Pure psychoanalysis is rarely practiced these days"; "In this metaphor, psychoanalysis is like superstring theory"; "The mid-20th century was the golden age of nurture. Psychoanalysis, behaviorism, and the spirit of the ‘60s". It most often appears alongside FeepingCreature, Freud, Lacan.

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psychoanalysis
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3
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3
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April 20, 2022
Last seen
June 26, 2025
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Highlights From The Comments On "Sadly, Porn"
April 20, 2022 · Original source
The book is meant to frustrate the reader. One difference between psychoanalysis and psychology is that the former is a series of meta-frames which allow you to scientifically generate knowledge about a single individual. So, to say the book has an overarching "point" is to miss the "meta-point", which is that the book takes as many angles as possible in hopes that one will hit, make you pissed off, and then hopefully get you thinking about why you got pissed off, and maybe discover something about yourself/your knowledge.
There are undoubtedly many smart, kind psychoanalysts who undertook the long, insanely expensive analytic training in hopes of learning to recognize something like subconscious patterns of thought. I know several. They way things play out in real life for many who got analytic training is that the training gives them some skills and schemas and forms of attunement that get tossed into the mix with all the other stuff they have learned or figured out or know instinctively about how to get people unstuck from various hells. Pure psychoanalysis is rarely practiced these days. Its glamor has faded and it is extremely expensive -- $450/ session in NYC, and patients come for 3-4 sessions/week - so there aren't a lot of customers.
I do think that of the various schools and styles of psychotherapy, unadulterated psychoanalysis is about the worst in terms of the power imbalance between patient and therapist. I would rather have some psychopharmacologist telling me I should take drug X in order to tame my attentional deficit, psychotic flares or whatnot than to have a psychoanalyst telling me he knows better than I do who I want to have sex with. The former would be giving me expert info about how to tame my brain with drugs -- the latter would be telling me he knows more than I do about who I am.
Book Review: A Clinical Introduction To Lacanian Psychoanalysis
April 26, 2022 · Original source
I know this is a weird way to start this book review. But I kept thinking about it while reading A Clinical Introduction To Lacanian Psychoanalysis, by Bruce Fink. Psychoanalysis - like AI alignment - is about how newly-created entities get desires, and what happens if the desire they get isn’t the one other people wanted them to have. Fink writes:
Inline links: A Clinical Introduction To Lacanian Psychoanalysis
Okay, that’s Lacanian philosophy in a nutshell! What about the clinical psychoanalysis?
Obsession, in which someone pretends that the Other doesn’t exist, they’re self-contained and don’t need anybody else, there’s no such thing as the unconscious, and nothing can possibly go wrong. Fink describes Ayn Rand characters as a “perfect” example, which I found helpful. Obsessives deal with their fear of sex by focusing on a single aspect of the sex partner (eg breasts, penis) and desperately trying to pretend they’re not a real full person. If you doubt the utility or veracity of Lacanian psychoanalysis (Fink warns us), it probably means you’re obsessive and that’s your defense mechanism.
Missing Heritability: Much More Than You Wanted To Know
June 26, 2025 · Original source
The mid-20th century was the golden age of nurture. Psychoanalysis, behaviorism, and the spirit of the ‘60s convinced most experts that parents, peers, and propaganda were the most important causes of adult personality.
PTSD3 mentions across 3 issues

PTSD is a recurring concept in the Astral Codex Ten archive, appearing 3 times across 3 issues between July 15, 2021 and January 25, 2024. The archive places it in contexts such as "predicted a [insert some term other than “wave”] of post-traumatic stress disorder cases"; "mental health conditions including depression, PTSD"; "The best-known is PTSD". It most often appears alongside Black Lives Matter, China, New York.

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PTSD
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3
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3
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July 15, 2021
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January 25, 2024
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Book Review: Crazy Like Us
July 15, 2021 · Original source
Foreign aid agencies sprung into action to try to support the survivors. Joining in the general mobilization were Western mental health professionals, who predicted a [insert some term other than “wave”] of post-traumatic stress disorder cases.
III. PTSD In Sri Lanka
According to [insert some author name other than “Watters”], mostly things went like this: foreign counselors would go into a refugee camp and tell everyone that they had to speak openly about their trauma and emotions. The survivors would say that it sucked a lot that their families had just been killed, but wouldn’t seem very emotional about it, or really confess to having “trauma” as classically understood. The therapists would say this was very bad, and they were keeping all of their emotions “bottled up”, and they really had to “let it out” or else it would fester and they would end up with PTSD. The refugees, who were never exactly clear which sets of white people were giving out free food and which ones weren’t, figured they ought to do what these people wanted in case they were the free food ones. So they would say, fine, they all felt very emotional and had lots of trauma. The therapists would be delighted and move on to the next camp.
Book Review: San Fransicko
June 23, 2022 · Original source
The San Francisco districts with the highest (left) and lowest (right) homelessness rates. I correlated homelessness rate and population-adjusted density in the same cities I looked at above, but it didn’t add much predictive value to housing prices. Maybe this is restriction of range (all big cities are dense enough to have homelessness, compared to suburbs), or maybe the key feature is relative rather than absolute density (ie the homeless will go to the densest place nearby). Conclusion: No social phenomenon is ever caused by just one thing, but San Francisco’s homelessness rate is around where a housing-cost-based model would predict. San Fransicko briefly touches on this, but overall tries to de-emphasize it in favor of talking about drugs and mental illness. Critiques of patterns of emphasis are necessarily subjective, but the book’s pattern feels misleading to me. Claim 2: Standard Accounts Underemphasize The Role Of Drugs And Mental Illness In Homelessness Having argued homelessness isn’t just about poverty, the book goes on to say we’re neglecting the central role of mental illness and substance abuse: Over the last decades there were many visible signs that homelessness was about much more than poverty and housing. Between 2010 and 2020, the number of calls made to San Francisco’s 311 line complaining of used hypodermic needles on sidewalks, in parks, and elsewhere rose from 224 to 6,275. In 2018, footage of dozens of people slumped over in an entrance to a Bay Area Rapid Transit (BART) station, many with needles in their arm, went viral. “We call it the heroin freeze,” said one local. “They can stay that way for hours.” Said another, “It’s like the land of the living dead.” For decades researchers have documented much higher levels of mental illness and substance abuse among the homeless than in the rest of the population. It’s true that just 8 and 18 percent of homeless people point to mental illness and substance abuse, respectively, as the primary cause of their homelessness, but researchers have long understood that such self-reports are unreliable due to the socially undesirable nature of substance abuse, and the lack of insight that often accompanies mental illness. Using other methods, San Francisco’s Health Department in 2019 estimated that 4,000 of the city’s 8,035 homeless, sheltered and unsheltered, are both mentally ill and suffering from substance abuse. Of those 4,000, about 1,600 frequently used emergency psychiatric services. Shellenberger’s source for 4000 homeless people having these issues is this SF Chronicle article, which seems to based off of this report. The report does estimate 4000 homeless people with mental illness and substance abuse, but it uses a yearly rather than point estimate of homelessness, and finds 18,000 rather than 8,000 people. That means it only finds a 22% rate of these problems, not a 50% rate. Thanks to commenter Sean for hunting down this report and helping explain this. I looked for other statistics to provide context on this number. This 2013 San Francisco Homeless Count found that 29% admitted chronic depression, 15% PTSD, and 22% some other mental illness. About 30% admitted to a substance use disorder, although as far as I can tell this is just the number who admitted it was a disorder, so maybe more used drugs. This article by the Los Angeles Times describes an LA study finding that 25% of homeless people had mental health issues and 14% had drug issues. The Times re-analyzes it in a way that ups the numbers to 34% and 46%, respectively. But they don’t say exactly what choices they made differently, and the few they do give don’t really inspire confidence. Although in some cases they count questions clearly about mental illness which the official definition inexplicably refused to count, in others they decide to count anyone who has ever had mental illness, reversing a government decision to require the mental illness to be long-term (does this mean that if I lost my house tomorrow, the LA Times use me as an example of a “mentally ill homeless person” because I saw a psychiatrist for OCD when I was a kid?) Studies like these don’t show causation. Sure, mental illness can make people homeless. But homelessness can also cause mental illness. One SF study found psych diagnoses among the homeless to be evenly divided among depression, PTSD, and everything else. Homelessness is a depressing and traumatic environment. Just because someone who’s been on the streets for a year has depression or trauma, doesn’t mean that we should attribute their homelessness to mental illness. This study by the California Policy Lab does better. It asks what factors played a role in homeless people losing their homes, and finds that 50% of unsheltered and 17% of sheltered homeless point to mental illness (given SF’s balance, that suggests 37% of SF homeless would point to that problem). But I can’t help but notice that when you add up the percent of people who lost their homes due to physical illness, psych illness, and drug use, it totals 147%. Based on numbers from other studies, it looks like if you added in job loss, eviction, etc, the numbers would total well above 400%. This makes me think people are saying “yes” if the factor played even a minor role in their eventual homelessness, and this shouldn’t be treated as 37% of homeless having mental health issues being their main problem. The same study finds that about 66% of the homeless “have” some mental health problem, but this time they don’t tell us what question they asked or what criteria they use. What about psychosis in particular? This meta-analysis claims that in developed countries (a category to which San Francisco still nominally belongs) about 19% of homeless people qualify for diagnosis with a psychotic disorder, including 9% with schizophrenia in particular. Not all people with psychotic disorders are completely crazy all the time, and some very much are not, but this is at least a specific condition with real criteria. Conclusion: Overall, I’m disappointed in most of the published research on this question, which seems more interested in producing glossy brochures about funding disparities than in informing anybody what any of their numbers mean. But putting it all together and squinting really hard, I think we can tell a story where 10-20% of the homeless are seriously psychotic, and another 20-30% have contributing mental health conditions including depression, PTSD, and others. Somewhere between 25% and 50% of the homeless have substance abuse problems, and this probably mostly overlaps with the 25% - 50% who have psych diagnoses. I think San Fransicko gets this mostly right. Claim 3: “Housing First” Isn’t As Great As People Think, And Might Be Harmful The National Myth About Homelessness is that The Bad People are refusing to give people houses until they’ve “proven” they “deserve” them, thus perpetuating homelessness when they inevitably fail to qualify. The Good People have united under an exciting new banner called “Housing First” to push the revolutionary idea that people should get houses regardless of whether they conform to normal standards of respectability or not. Wherever this is adopted, homelessness rates fall, and the formerly homeless becoming healthier, safer, and more likely to re-integrate into society. Best of all, the program pays for itself in decreased health care and policing costs. The only impediment to solving homelessness everywhere is the Bad People who still insist on not housing the homeless until they’ve “earned” it. In real life, everyone important has been united under Housing First since the Bush administration made it national policy fifteen years ago, and most of the cities with spiraling homelessness crises have been pursuing Housing First policies for decades (eg San Francisco has been trying Housing First since the 1990s). The Obama and Trump administrations both set funding policies that penalized any non-Housing-First welfare programs. Still, everyone is sure that the reason there are still homeless people must be that some Housing First opponent still exists somewhere, ruining everything with their purity-testing ways. But actually these people have already been relegated to the conservative think tanks where moribund ideas go to die. I have looked through a lot of studies and articles to try to see how well Housing First works. I am most sympathetic to the conclusions of Tsai (2020), who basically says that: Homeless people who are given houses are more housed than homeless people who are not given houses. Way, way more housed. You would not believe how strong of an effect giving someone housing has on them being housed. The same is true for other outcome measures like “time spent experiencing homelessness”, “number of days spent in a temporary homeless shelter”, etc. You might think this is obvious, but this is used as the primary outcome in a lot of studies, and “success” on this metric is behind a lot of claims that “studies show Housing First works great!”
Inline links: this SF Chronicle article, this report, 2013 San Francisco Homeless Count, This article, This study, This meta-analysis, some very much are not, made it national policy, since the 1990s, funding policies, Tsai (2020)
The Psychopolitics Of Trauma
January 25, 2024 · Original source
Politics can become something between an addiction and an obsession. People can spend hours every day watching cable TV or scrolling through their Twitter feeds, trying to stay abreast of the latest outrage the other side is perpetrating. To be clear, they hate this. Each time they hear another outrage they’re somewhere between dejected and enraged. But they keep doing it. For hours a day. They will justify this with claims like “I need to stay informed so I can make a difference”. Then they will forget to vote because they were tired on Election Day. In any other situation, a condition with impaired cognition, psychotic symptoms, emotional instability that impaired normal functioning, and associated addictions/obsessions would qualify as a mental disorder. So again, which mental disorder is it? This post is about the possibility that it might be trauma. II. When Donald Trump was elected, some people described themselves as “traumatized”. Someone asked me for comment on the record, hoping I would say something like “as a real psychiatrist, trauma is a real disorder with strict criteria, and all you people are dumb”. I did not, in fact, make this comment. “Trauma” isn’t technically a mental disorder. The DSM contains seven “trauma and stressor related disorders”, of which the best-known is PTSD. An eighth disorder, “complex PTSD”, didn’t quite make it into the DSM but has been accepted by other classification systems, including the ICD-10 and WHO; other proposed trauma disorders are even less well-established. “Trauma” itself is a vague word encompassing all of these plus many less-well-defined situations. Although the vague concept “trauma” goes well beyond the DSM’s formal definition of PTSD, I think the latter makes a good reference point. Let’s look at the diagnostic criteria: [A trauma victim is someone who has] exposure to “actual or threatened death, injury, or sexual violence in one or more of the following ways: Directly experiencing the traumatic event(s).
Experiencing repeated or extreme exposure to aversive details of the traumatic event(s) (e.g., first responders collecting human remains; police officers repeatedly exposed to details of child abuse). This is already quite broad! The victim doesn’t need to have anything bad happen to them - just be threatened with it. And they don’t need to personally be the victim of the threat. They can learn that it happened to someone close to them, or they can just hear about it happening to someone else. A police officer who hears about child abuse may be a trauma victim! The DSM’s job is to draw a medico-legal boundary - this counts, but that doesn’t. The real world has no obligation to obey the DSM, and often doesn’t. For example, can someone be traumatized by something happening to a distant family member? It would be insane to think this has never happened, and that some law of nature limits it to close family members. The DSM is just using the heuristic that probably it’s worse when it’s someone close to you. It goes on: [Part 4] does not apply to exposure through electronic media, television, movies, or pictures, unless this exposure is work-related. Did someone prove it was a natural law that you can only be traumatized by seeing a story on TV if it’s for work? Or is this another unprincipled compromise? People not involved in the DSM, unbound by medicolegal considerations, have added all kinds of stuff to this basic definition. For example, even though it’s not in the strict DSM definition, psychologists almost universally agree that emotional abuse can be traumatizing. And in the current social climate, inevitably people have started talking about collective trauma, eg institutional racism may be traumatizing for some individual black person even if they personally have never been victimized in any dramatic way. The knowledge that people hate their whole group serves as an adequate proxy for anybody abusing them personally. Can you chain all of these exceptions together? Can witnessing a family member suffering emotional abuse be traumatizing? Can learning secondhand about someone encountering institutional racism be traumatizing? Can you be traumatized by hearing on TV that someone was emotionally abused on account of their race? Only if it’s part of your job? At this point the nice crisp distinctions of the DSM are starting to feel a little artificial. I think of all of this in a deflationist, spectrum-y type of way. Anything can be traumatizing if it gives you strong negative emotions and makes you feel helpless and victimized. The DSM points to some categories that are especially likely to cause this kind of reaction. Other people have added their own. But if something you hear on TV makes you feel victimized and helpless, then sure, go ahead and call it traumatizing. If Trump’s election made you feel victimized and helpless, then I’m prepared to say “trauma” is a potentially fruitful lens through which to investigate this response. (I’m not saying that Trump’s election was inherently traumatizing, or that trauma was the correct response. If you prefer, you can think of it as a condemnation of the media for irresponsibly fanning fear of Trump. I’m just saying, without trying to lay blame, that lots of people did experience feelings of fear and helplessness around Trump’s election.) III. I didn’t personally feel traumatized by Trump’s election. My own story, which I don’t claim is atypical or sympathetic in any way, is that in college a bunch of people tried to cancel me for something I’d intended to be an anti-racist joke, but which apparently didn’t come out that way. Former friends turned against me, I got a few death threats, and I was told to attend a criticism session at a local social justice meeting group (which I foolishly did; I thought people would realize I was cooperative and agreed with them, and so lay off - obviously this didn’t work). I briefly considered dropping out of college to avoid the hatred; instead I spent a month locked in my room, waiting for the storm to blow over. It was the worst experience of my life. Ever since then, when I read arguments promoting social justice and cancel culture, or saying that their victims are probably bad people and shouldn’t be allowed to defend themselves, I get all kinds of easily noticeable unpleasant bodily and emotional reactions. When I read good arguments against these positions, I get some kind of nice calm feeling, like that I’m suddenly safer and the world has brightened a little bit. I try as hard as I can to approach these kinds of issues fairly, but it wouldn’t surprise me if I make more of the “five Democrats and eight assault weapons” style reasoning errors there than I would on some boring topic like taxes. Of course, I hear similar stories from people on the other side of this particular culture war. A typical example (this is a pastiche of many people) would be a transgender person who sometimes gets harassed when they try to go into public restrooms. Even if it never gets beyond catcalling, they remember all the stories they read about trans people getting murdered, and even looks of disapproval feel like they carry the potential for physical violence. Then they hear about trans bathroom bills in North Carolina or wherever and absolutely see red; they feel like Society as an abstracted entity is trying to deny their right to exist. Then they invent entirely new kinds of social technology to prevent themselves from ever having to talk to or interact with the sort of people who would support such a thing. Most people haven’t personally been cancelled or discriminated against, and they might not have stories like these. But they might feel like society is “threatening” them with these kinds of experiences. Or they might have “close family” or “close friends” who qualify. Or they might have heard about them on TV. (In a work-related context? Sure, let’s say yes.) But also, there’s the collective trauma exemption! Everybody belongs to various groups - black people, white people, Jews, Christians, men, women, LGBTs, gun owners, socialists, cops. Parts of each of these groups have developed narratives about how they’re being singled out for special persecution by the people in power. You probably believe that some of these groups’ narratives are valid, and others are false and offensive. That doesn’t matter. The important thing is that (some of) the group members believe it. The DSM is quite clear that people react to threatened trauma, not actual trauma. If some very silly person works himself up into a frenzy believing he’s being abused and persecuted because he eats eggs for breakfast, that’s potentially traumatizing, even if his concerns have no basis. But also, everyday political debate crosses lines that would qualify as emotional abuse in any other sphere of life. People get told they’re disgusting or idiotic or deserve to die. They have to watch as powerful rivals plot openly how to ostracize them from polite society. Groups of their enemies get together to spread the rumor that they are Satanists, Nazis, or pedophiles. They have their views twisted into totally false claims that they want to murder children, which then “go viral” to people who otherwise know nothing about them. If you’re not famous, this might not happen to you personally - nobody says “John Smith is a Nazi pedophile”. But John Smith might be a socialist, and someone might say “All socialists are Nazi pedophiles”. If we believe that racism can traumatize minority individuals even if they’re not personally named in the stereotypes, we should believe that the discourse around socialism can traumatize socialists, even if they’re not personally involved. I’m probably not describing this well, so I can only beg you to supplement my inadequate words with your lived experience. All bullying sounds trivial when you’re not involved. “He called me a fatty on the playground!” Well, whatever, laugh it off. But somehow from the inside, iterated over many experiences, coming from people you perceive as more socially powerful than you, it creeps up on you, starts getting power you definitely don’t remember giving it. Think of some discourse you’re involved in, some issue you feel really invested in, and think about the people you find most unfair and enraging on the other side. I dunno, either you’ve had this experience or you haven’t. I think a lot of people feel persecuted and threatened by politics, a lot of people feel emotionally abused by politics, and a lot of people feel like they’ve had vicarious experiences of people they identify with being harmed by politics. This isn’t enough for a formal PTSD diagnosis - they probably didn’t watch the relevant TV news segments in a work-related context. But it might be enough to start doing some really unhealthy things to their brains. IV. Here’s what the DSM has to say about some symptoms of PTSD: B4: Intense or prolonged psychological distress at exposure to internal or external cues that symbolize or resemble an aspect of the traumatic event. The popular term for criterion B4 is “a trigger”. For example, if you were raped, you might be triggered by hearing someone describe rape. This is justification for so-called “trigger warnings” in books and movies. Triggers have long since jumped from the lexicon of PTSD to the lexicon of politics. Left-wingers describe exposure to right-wing ideas or symbols as “triggering”. Right-wingers try to avoid the terminology, because it sounds too leftie, but they have the experience so often that lefties asking right-wingers “oh, are you TRIGGERED?” has become a meme. Twitter searches for “triggered” are an interesting anthropological experience. A Google search brought up this lovely t-shirt. I think eBay’s policy of promoting inclusiveness by displaying shirts on ethnically diverse models may have failed them in this case. This is only the tip of the iceberg. Donald Trump Jr has a book called Triggered, and a biweekly TV show of the same name. Sheila Jeffreys’ biography is called Trigger Warning: My Radical Feminist Life. Jeffreys and Trump Jr may not have much else in common, but they are united by a shared appreciation for applying this technical psychiatric term to politics. I think this makes the most sense if political triggering and psychiatric triggering are literally the same thing because political toxicity is a subspecies of PTSD. D2: Persistent and exaggerated negative beliefs or expectations about oneself, others, or the world. Do I even need to explain this one? D3: Persistent distorted cognitions about the cause or consequences of the traumatic events that lead the individual to blame himself or others. As stated, this doesn’t really apply to politics. But I claim this is an overly restrictive description of the true problem, which is a general distortion of cognition around traumatic stimuli. See for example Reasoning, trauma, and PTSD: insights into emotion–cognition interaction. Here the researchers make people solve math/logic puzzles with five apples and eight oranges or whatever; as usual, most people do fine. Then they change the content to traumatic stimuli, like five rapists and eight abusers. Nobody is particularly happy about this change, but traumatized people seem to do worse when the stimuli relate to their own trauma. This is an exact analog to the “five Democrats and eight assault weapons” task discussed above; I don’t know if one line of research inspired the others, but they show some similar results. Other people have even more general findings. You may remember the Stroop Effect, where people have to say the color of words without getting distracted by their content. One variant is the Emotional Stroop Effect, where instead of giving color words (“yellow”, “red”, etc), you use emotional words and traumatic stimuli. Traumatized people tend to do worse at Emotional Stroop tasks relating to their specific trauma. See Modification of cognitive biases related to posttraumatic stress: A systematic review and research agenda. See also The Precision Of Sensory Evidence for a discussion of how this effect might happen. E1: Irritable behavior and angry outbursts (with little or no provocation) typically expressed as verbal or physical aggression toward people and objects. As seen at your family Thanksgiving table. Politics makes otherwise kind people into angry jerks. E3: Hypervigilance This is defined as a heightened awareness of surroundings, constantly scanning for danger, and misinterpreting innocuous stimuli as threatening. Wikipedia describes it as “there is a perpetual scanning of the environment to search for sights, sounds, people, behaviors, smells, or anything else that is reminiscent of activity, threat or trauma”. Dog whistles. Microaggressions. The hallmark of the advanced political partisan is the ability to describe everything the other side (or neutral third parties) do as secretly a political offense, and to reduce every possible situation to their issue of choice. For the past ten years, I’ve been involved in the anti-AI-existential risk movement, and have gotten to know other people in this movement pretty well. I can say with high certainty that the number one motive of these people is that they do not want to be killed by robots. Still, over the years people have ascribed every possible motive to us except that one, for example: It’s a plot by Big Tech to distract from other harms they are committing.
Inline links: emotional abuse, institutional racism may be traumatizing, entirely new kinds of social technology, https://substackcdn.com/image/fetch/$s_!G65x!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F9be25ee8-5d77-4a57-a07d-efff5ff66b44_589x461.png, https://substackcdn.com/image/fetch/$s_!i3Mp!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F69cd8c8a-3f2b-4842-b8fd-1455aa1310bf_591x587.png, Triggered, Trigger Warning: My Radical Feminist Life, Reasoning, trauma, and PTSD: insights into emotion–cognition interaction, Modification of cognitive biases related to posttraumatic stress: A systematic review and research agenda., The Precision Of Sensory Evidence, Dog whistles
A Google search brought up this lovely t-shirt. I think eBay’s policy of promoting inclusiveness by displaying shirts on ethnically diverse models may have failed them in this case. This is only the tip of the iceberg. Donald Trump Jr has a book called Triggered, and a biweekly TV show of the same name. Sheila Jeffreys’ biography is called Trigger Warning: My Radical Feminist Life. Jeffreys and Trump Jr may not have much else in common, but they are united by a shared appreciation for applying this technical psychiatric term to politics. I think this makes the most sense if political triggering and psychiatric triggering are literally the same thing because political toxicity is a subspecies of PTSD. D2: Persistent and exaggerated negative beliefs or expectations about oneself, others, or the world. Do I even need to explain this one? D3: Persistent distorted cognitions about the cause or consequences of the traumatic events that lead the individual to blame himself or others. As stated, this doesn’t really apply to politics. But I claim this is an overly restrictive description of the true problem, which is a general distortion of cognition around traumatic stimuli. See for example Reasoning, trauma, and PTSD: insights into emotion–cognition interaction. Here the researchers make people solve math/logic puzzles with five apples and eight oranges or whatever; as usual, most people do fine. Then they change the content to traumatic stimuli, like five rapists and eight abusers. Nobody is particularly happy about this change, but traumatized people seem to do worse when the stimuli relate to their own trauma. This is an exact analog to the “five Democrats and eight assault weapons” task discussed above; I don’t know if one line of research inspired the others, but they show some similar results. Other people have even more general findings. You may remember the Stroop Effect, where people have to say the color of words without getting distracted by their content. One variant is the Emotional Stroop Effect, where instead of giving color words (“yellow”, “red”, etc), you use emotional words and traumatic stimuli. Traumatized people tend to do worse at Emotional Stroop tasks relating to their specific trauma. See Modification of cognitive biases related to posttraumatic stress: A systematic review and research agenda. See also The Precision Of Sensory Evidence for a discussion of how this effect might happen. E1: Irritable behavior and angry outbursts (with little or no provocation) typically expressed as verbal or physical aggression toward people and objects. As seen at your family Thanksgiving table. Politics makes otherwise kind people into angry jerks. E3: Hypervigilance This is defined as a heightened awareness of surroundings, constantly scanning for danger, and misinterpreting innocuous stimuli as threatening. Wikipedia describes it as “there is a perpetual scanning of the environment to search for sights, sounds, people, behaviors, smells, or anything else that is reminiscent of activity, threat or trauma”. Dog whistles. Microaggressions. The hallmark of the advanced political partisan is the ability to describe everything the other side (or neutral third parties) do as secretly a political offense, and to reduce every possible situation to their issue of choice. For the past ten years, I’ve been involved in the anti-AI-existential risk movement, and have gotten to know other people in this movement pretty well. I can say with high certainty that the number one motive of these people is that they do not want to be killed by robots. Still, over the years people have ascribed every possible motive to us except that one, for example: It’s a plot by Big Tech to distract from other harms they are committing.
Inline links: Triggered, Trigger Warning: My Radical Feminist Life, Reasoning, trauma, and PTSD: insights into emotion–cognition interaction, Modification of cognitive biases related to posttraumatic stress: A systematic review and research agenda., The Precision Of Sensory Evidence, Dog whistles
P=NP2 mentions across 2 issues

P=NP is a recurring concept in the Astral Codex Ten archive, appearing 2 times across 2 issues between February 15, 2023 and July 26, 2025. The archive places it in contexts such as "I get emails every single day from P=NP crackpots"; "explaining why P=NP is a difficult problem". It most often appears alongside ACX, ivermectin, 4chan.

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P=NP
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2
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2
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February 15, 2023
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July 26, 2025
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Trying Again On Fideism
February 15, 2023 · Original source
This is a great post that contains a lot of truth. And yet … I also see a grain of truth in Kavanagh’s position. Like, I get emails every single day from P=NP crackpots and quantum mechanics crackpots and now AI crackpots too. Some of them probably *would* be better off never trying to think for themselves again, and just Trusting Science and Trusting the Experts. Sure, the experts are sometimes confidently wrong, but not as consistently so as they are! And for my part, I can’t possibly write 25,000 words to explain why each and every crackpot is wrong. As a matter of survival, I *have* to adopt a Kavanagh-like heuristic: “this person seems like an idiot.”
Your Review: The Astral Codex Ten Commentariat (“Why Do We Suck?”)
July 26, 2025 · Original source
I think, in hindsight, that this is reflecting a unique characteristic of the ACX Commentariat, which is that it is unusually likely to develop an idea or conceptual schema rather than just asserting something and moving on. For example, here’s a Comment of the Week where Anatoly spends a very long time explaining the different meanings of ‘infinite’ and ‘finite’ in the context of explaining why P=NP is a difficult problem. It has a Brunet Index of 14.3 (so a little less than double the local average) because it repeats the words ‘infinite’, ‘finite’ and ‘algorithm’ many times. But I agree with the responses that this is a great comment, and exactly the sort of thing which only the ACX Commentariat seems to produce with any regularity. For a more recent example, here’s another comment of the week by Benjamin Jolley which adds some details to Scott’s post The Compounding Loophole, and is also clearly a great post which fits very well into the Commentariat corpus. So my conclusion here is that documentation for these tests assumes that stale vocabulary is always bad, because it expects you to be using the tests on – for example - novels. However, stale vocabulary isn’t inherently good or bad, and in this case it serves as a marker for something the Commentariat like or value. Anecdotally, it looks like what the Commentariat value is something like ‘well defined terms’. Even if this doesn’t map cleanly to something we can point to, there’s no accounting for taste - if the Commentariat just happen to prefer lengthy stale sentences there’s nothing actually wrong with that. Therefore, this measure is consistent with the other measures of complexity even though it very clearly shows the opposite relationship than I expected. Just for fun, I thought I would show the most repetitive comment ever written. This was actually slightly difficult as there are a lot of things which are both comments and repetitive but which would be uninteresting to count (spam, code snippets, pasted text from early LLMs where the model hangs and repeats the same text to infinity). The most repetitive non-spam comment which I reckon was generated by humans alone is this comment by Deiseach, which quotes extensively from an early Irish law book (Brunet = 16.9). The most repetitive non-spam comment which I reckon has a single human author is this comment by Fahundo (Brunet = 16.5), giving the answer to a logic problem in ROT13 (so actually possibly breaks the rule about not using a computer in the writing, but not in the way I meant!) Complexity Approach 4 – Reading age Finally, I looked at reading age, although this approach was largely unsuccessful. ‘Reading age’ is an approximate composite measure of the complexity of language and sentence construction in a piece of text. There are quite a few different measures of reading age, which all show roughly the same outcome in my data. The one I have depicted below is the Flesh-Kincaid Grade level, which roughly tracks how many years of continuous schooling you would theoretically need to read and understand the text. The Commentariat is a largely very intellectual bunch and so a typical reading age of around 10.5 is unsurprising (a typical SSC/ACX comment is just barely less complex than an academic article in terms of vocabulary and construction, and the most complex comments significantly exceed this). The graph shows that comment complexity jumps by approximately half a grade level when SSC becomes ACX, but I’m a bit sceptical this is a ‘real’ effect. Most reading age formulae track sentence length very closely, and for some reason sentence length also changes significantly around this time. I could genuinely believe that sentence length changes on the switch to ACX, but I don’t think measures of reading age are designed to be valid if sentence length is changing for reasons unrelated to the complexity of text, so I don’t think you can confidently conclude the ACX comments are more sophisticated from this measure alone. Complexity - Conclusions Overall, it is appropriate to discover that my measure of ‘complexity of thought’ is itself complex. We do see very clear peaks in the SSC era, but not actually quite in the place we expected to see them. Similarly, we don’t always see the peak in the direction we expect (sentences are long and stale in the peak SSC years, which doesn’t seem like a recipe to promote engagement). Finally, we have a puzzle about how the Substack UI/UX causes significantly fewer sentences per comment. My conclusion here is that these data are completely consistent with a Commentariat who have a particular thing that they like, which peaked in 2017. This thing quantitively looks like long stale sentences, but actually might qualitatively feel different – like for example careful definitions of words which are then used repeatedly. As for why the peak sentence length is after peak engagement, my best guess is that people didn’t stop engaging at random; the people with the strongest commitment to the Commentariat stuck around longest, and these are also the people with the most respect for SSC cultural norms (leave long, thoughtful comments) and willingness to dedicate time to commenting. I have heard this described as ‘evaporative cooling’ before. This group of ‘fanatics’ hung around for a bit longer than everyone else, but eventually either they mostly left too or their influence on discussion norms was not strong enough to prevent a reversion towards the comment section mean (which tends towards shorter and less rigorous comments) What happened in 2016? From the data I extracted, it is clear something happened to the Commentariat in 2016(ish) and again in 2021 with the switch to ACX. Of the four measures I presented: Depth of engagement shows two clear directional reversals in 2016 and 2021
Inline links: here’s, here’s, The Compounding Loophole, this, this, https://substackcdn.com/image/fetch/$s_!EIYh!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Ff6ac85e8-5bee-420c-8c36-205ae697484c_749x394.png, evaporative cooling’
paganism2 mentions across 2 issues

paganism is a recurring concept in the Astral Codex Ten archive, appearing 2 times across 2 issues between September 20, 2024 and December 17, 2024. The archive places it in contexts such as "hope as one of the primary distinguishers between Christianity and paganism"; "typical replacement-level paganism". It most often appears alongside Christianity, London, 2016 US Presidential election.

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paganism
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2
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2
First seen
September 20, 2024
Last seen
December 17, 2024
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Your Book Review: The Ballad of the White Horse
September 20, 2024 · Original source
Here we are introduced to one of Chesterton’s core themes: hope versus fate. Chesterton sees hope as one of the primary distinguishers between Christianity and paganism, buddhism, eastern philosophy in general, and materialistic determinism. We see this same dichotomy in another of Chesterton’s great poems, Lepanto, where he has Muhammed, enthroned in glory in the Muslim paradise, say:
Links For December 2024
December 17, 2024 · Original source
55: The “fastest growing new religion in the world” is the cult of Santa Muerte (St. Death) in Mexico, with perhaps 29 million followers since going public in 2001. I find it hard to determine its appeal - the entire content of the religion seems to be “if you give sacrifices to an idol of a female skeleton, she will grant your prayers”. It’s not just that this is boring - it’s that it’s absolutely typical replacement-level paganism, and I’d always thought that Christianity beat paganism because it was inherently more attractive. Yet the Mexican youth are turning away from the stodgy boring Catholic Church en masse to worship Santa Muerte. Why?
Inline links: Santa Muerte, Christianity beat paganism because it was inherently more attractive
pancreas2 mentions across 2 issues

pancreas is a recurring concept in the Astral Codex Ten archive, appearing 2 times across 2 issues between May 23, 2024 and August 13, 2024. The archive places it in contexts such as "33% know what organ produces insulin (pancreas)"; "GLP-1 tells the pancreas to release more". It most often appears alongside 1984, 1984 Calendar Meme, ACX.

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pancreas
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2
Issue count
2
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May 23, 2024
Last seen
August 13, 2024
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A Theoretical "Case Against Education"
May 23, 2024 · Original source
33% know what organ produces insulin (pancreas)
Why Does Ozempic Cure All Diseases?
August 13, 2024 · Original source
Since eating a meal increases blood sugar, your body wants to push blood sugar back down. So GLP-1 tells the pancreas to release more insulin (sugar ↓) and less glucagon (sugar ↑).
pandemic2 mentions across 2 issues

pandemic is a recurring concept in the Astral Codex Ten archive, appearing 2 times across 2 issues between July 08, 2022 and February 19, 2026. The archive places it in contexts such as "the beginning of the pandemic"; "peaks during the pandemic". It most often appears alongside San Francisco, 1/6 insurrection, ACLU.

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pandemic
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2
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2
First seen
July 08, 2022
Last seen
February 19, 2026
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Highlights From The Comments On The 2020 Homicide Spike
July 08, 2022 · Original source
The people buying new guns are mostly (~80%) people who have guns already. This varies a bit by time period but other periods (the beginning of the pandemic and the 1/6 insurrection) were more disproportionately new gun owners than the June period when homicides started to spike. This also shows that the largest month-over-month increases in gun purchases, both new and total, were March 2020 and January 2021. There was no sudden homicide spike associated with either of these months, only May/June 2020. Finally, guns are usually more correlated with suicide deaths than with homicide deaths… State by state correlation between gun ownership and murder rates (left), and between gun ownership and suicide rates (right). Source here. …but there was no spike in suicides at the same time as the murder spike: Source This is what you’d expect given that the number of guns only increased by 2% over trend - a completely invisible effect on suicide. Unrelatedly, homicides rose by 30%. So the gun hypothesis requires that: Crime tracks the flow, rather than the stock, of guns.
Inline links: https://substackcdn.com/image/fetch/$s_!TQUx!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F5918467a-45dc-4e87-a2ab-230744fda597_1015x404.png, here, https://substackcdn.com/image/fetch/$s_!EJEG!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2Fbb830b21-3151-4e54-9310-c3c29a0436bb_325x235.png, Source
Also, what would be the explanation for why this trend would start on May 20 or something? There isn’t more pandemic that day. There aren’t more guns that day. It’s not even especially warm that day. I think it’s got to be an artifact.
This is just as compatible with the timing of the evidence you've described, including the pre-pandemic stuff in Baltimore and Ferguson.
Crime As Proxy For Disorder
February 19, 2026 · Original source
Litter: Roadside litter (eg on highways) decreased 80% since records began in 1969 (1, 2), but it’s unclear if this extends to urban environments. New York City has a litter inspection and rating system that’s been in place since 1973, and they also report improvement - “from roughly 70 percent acceptably clean in the 1970s to over 90 percent clean now” - although citizens protest that the system doesn’t match their experience. National surveys find that the percent of people who admit to littering has gone down from 50% in 1969 to 15% today. None of these are knockdown evidence on their own, but taken together and added to the overall crime trends, the evidence for a secular trend downwards is convincing. The more recent numbers are all confounded by the pandemic, and I have no confidence in the direction of the trend since 2010.
Inline links: 1, 2, citizens protest, has gone down
I’ve confirmed the post 2009 trend; I haven’t fully double-checked the others but they match my impressions. This looks like a similar pattern to crime, although here the likely explanation for the COVID bump is the pandemic-associated rise in house prices. Good measures of tent encampments over long periods are hard to find. San Francisco has this one: …but it starts in 2019, peaks during the pandemic, and then declines. This can’t really show whether 2019 was already higher than some previous year. Here is an interesting graph of Seattle homeless sweeps, ie number of times the police acted against encampments: …but it doesn’t tell us whether encampments are increasing, or the police are taking them more seriously. It does rule out a story where encampments are increasing because the police are no longer taking action - aside from the pandemic, police are taking more action than ever, at least as measured here. People With Loud Boom Boxes In Public Places: All I have to say about this one is that it’s terrible and I hate it. Overall, it’s surprisingly hard to find data confirming that disorder has increased: Littering seems to be down
Inline links: the pandemic-associated rise in house prices, has, https://substackcdn.com/image/fetch/$s_!IP1D!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F3dcf3fdb-3af0-4c26-b2c9-0525d4ab4800_807x615.png, Here, https://substackcdn.com/image/fetch/$s_!tv-7!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F3458f2f2-becc-4a5b-bb89-3644d599d9d2_960x540.png
…but it starts in 2019, peaks during the pandemic, and then declines. This can’t really show whether 2019 was already higher than some previous year. Here is an interesting graph of Seattle homeless sweeps, ie number of times the police acted against encampments: …but it doesn’t tell us whether encampments are increasing, or the police are taking them more seriously. It does rule out a story where encampments are increasing because the police are no longer taking action - aside from the pandemic, police are taking more action than ever, at least as measured here. People With Loud Boom Boxes In Public Places: All I have to say about this one is that it’s terrible and I hate it. Overall, it’s surprisingly hard to find data confirming that disorder has increased: Littering seems to be down
Inline links: Here, https://substackcdn.com/image/fetch/$s_!tv-7!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F3458f2f2-becc-4a5b-bb89-3644d599d9d2_960x540.png
paracetamol2 mentions across 2 issues

paracetamol is a recurring concept in the Astral Codex Ten archive, appearing 2 times across 2 issues between November 17, 2021 and April 13, 2022. The archive places it in contexts such as "unable to separate out the ivermectin from the other things in the kit (paracetamol and aspirin)"; "Tylenol (aka Panadol, paracetamol, acetaminophen, etc)". It most often appears alongside CDC, Vitamin D, ACE-2 receptor.

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paracetamol
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2
Issue count
2
First seen
November 17, 2021
Last seen
April 13, 2022
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Ivermectin: Much More Than You Wanted To Know
November 17, 2021 · Original source
Click to expand. # is how many people were in the smallest relevant group (eg if there were 20 people in placebo and 10 in ivermectin, it was 10). Dose is ivermectin dose x number of days. Tested w/ is what drugs were given alongside ivermectin; compare is what drugs were in the “placebo” group (I excluded some very common things like paracetamol). %-PCR7 is what percent of patients had a negative PCR test (indicating recovery) after 7 days (though if 7 wasn’t available, I accepted anything from 6-12); the (I) and (P) are ivermectin and placebo groups. R is the ratio - green if statistically significant, red otherwise. DaysPCR is how many days it took to get a negative PCR test. Days to -sym are how many days it took symptoms to resolve. -outc is some serious negative outcome in the study, either clinical worsening, hospitalization, or death. I was inconsistent which one I chose, trying to pick whichever I thought struck a balance between high sample size and severity. Since this was almost never significant, I made it blue if it favored ivermectin and orange if it favored placebo (which it never did; there is no orange). Lowest p is the lowest p-value in the study for one of the headline results. 1o+ is whether the primary outcome was positive or not. I made this very quickly and unprincipledly and I am sure there are a lot of errors; please forgive me. Of studies that included any of the endpoints I recorded, ivermectin had a statistically significant effect on the endpoint 13 times, and failed to reach significance 8 times. Of studies that named a specific primary endpoint, 9 found ivermectin affected it significantly, and 12 found it didn’t. But that’s still pretty good. And “doesn’t affect to a statistically significant degree” doesn’t mean it doesn’t work. It might just mean your study is too small for a real and important effect to achieve statistical significance. That’s why people do meta-analyses to combine studies. And the ivmmeta people say they did that and it was really impressive. All of this is still basically what things would look like if ivermectin worked. But of course we can’t give every study one vote. We’ve got to actually look at these and see which ones are good and which ones are bad. So, God help us, let’s go over all thirty of the ivermectin studies in this top panel of ivmmeta.com. (if you get bored of this, scroll down to the section called “The Analysis”) The Studies Elgazzar et al: This one isn’t on the table above, but we can’t start talking about the others until we get it out of the way. 600 Egyptian patients were randomized into six groups, including three that got ivermectin. The ivermectin groups did substantially better: for example, 2 vs. 20 deaths in ivermectin group 3 vs. non-ivermectin group 4. There were various other equally impressive outcomes. Unfortunately, it’s all false. Some epidemiologists and reporters were able to obtain the raw data (it was password-protected, but the password was “1234”), and it was pretty bizarre. Some patients appeared to have died before the trial started; others were arranged in groups of four such that it seemed like the authors had just copy-pasted the same four patients again and again. Probably either the study never happened, or at least the data were heavily edited afterwards. You can read more here. A lot of the apparent benefit of ivermectin in meta-analyses disappeared after taking out this paper (though remember, this isn’t even on the table at the top of the post, so it doesn’t directly affect that). Since the Elgazzar debacle, a group of researchers including Gideon Meyerowitz-Katz, Kyle Sheldrake, James Heathers, Nick Brown, Jack Lawrence, etc, have been trying to double-check as many other ivermectin studies as possible. At least three others - Samaha, Carvallo, and Niaee - have similar problems and have been retracted. Those studies were all removed before I screenshotted the table above, and they’re not on there. But everybody is pretty paranoid right now and looking for fraud a lot harder than they might be in normal situations. Moving on: Chowdury et al: Bangladeshi RCT. 60 patients in Group A got low-dose ivermectin plus the antibiotic doxycycline, 56 in Group B got hydroxychloroquine (another weird COVID treatment which most scientists think doesn’t work) plus the antibiotic azithromycin. No declared primary outcome. Ivermectin group got to negative PCR a little faster than the other (5.9 vs. 7 days) but it wasn’t statistically significant (p = 0.2). A couple of other non-statistically-significant things happened too. 2 controls were hospitalized, 0 ivermectin patients were. This is a boring study that got boring results, so nobody has felt the need to assassinate it, but if they did, it would probably focus on both groups getting various medications besides ivermectin. None of these other medications are believed to work, so I don’t really care about this, but you could tell a story where actually doxycycline works great at addressing associated bacterial pneumonias, or where HCQ causes lots of side effects and that makes the ivermectin group look good in comparison, or whatever. Espitia-Hernandez et al: Mexican trial which is probably not an RCT - all it says is that “patients were voluntarily allocated”. 28 ended up taking a cocktail of low-dose ivermectin, vitamin D, and azithromycin; 7 were controls. On day ten, everyone (!) in the experimental group was PCR negative; everyone (!) in the control group was still positive. Also, symptoms in the experimental group lasted an average of three days; in the control group, more like 10. These results make ivermectin look amazingly super-good, probably better than any other drug for any other disease, except maybe stuff like vitamins for treatment of vitamin deficiency. Any issues? We don’t know how patients were allocated, but they discuss patient characteristics and they don’t look different enough to produce this big an effect size. The experimental group got a lot of things other than ivermectin, but I would be equally surprised if vitamin D or azithromycin cured COVID this effectively. It deviated from its preregistration in basically every way possible, but you shouldn’t be able to get “every experimental patient tested negative when zero control patients did” by garden-of-forking-paths alone! But this has to be false, right? Even the other pro-ivermectin studies don’t show effects nearly this big. In all other studies combined, ivermectin patients took an average of 8 days to recover; in Espitia-Hernandez, they took 3. Also, it’s pretty weird that the entire control group had positive PCRs on day 10 - in most other studies, a majority of people had negative PCRs by day 7 or so, regardless of whether they were control or placebo. Everything about this is so shoddy that I can easily believe something went wrong here. I don’t have a great understanding of this one but I don’t trust it at all. Luckily it is small and non-randomized so it will be easy to ignore going forward. I’m not saying this is related, but I’m not saying it *isn’t* related either. Carvallo et al: This one has all the disadvantages of Espitia-Hernandez, plus it’s completely unreadable. It’s hard to figure out how many patients there were, whether it was an RCT or not, etc. It looks like maybe there were 42 experimentals and 14 controls, and the controls were about 10x more likely to die than the experimentals. Seems pretty bad. On the other hand, another Carvallo paper was retracted because of fraud: apparently the hospital where the study supposedly took place said it never happened there. I can’t tell if this is a different version of that study, a pilot study for that study, or a different study by the same guy. Anyway, it’s too confusing to interpret, shows implausible results, and is by a known fraudster, so I feel okay about ignoring this one. Mahmud et al: RCT from Bangladesh. 200 patients received ivermectin plus doxycycline, 200 received placebo. Everything was written up very nicely in real English, by people who were clearly not on 34 lbs of meth at the time. They designated a primary outcome, “number of days required for clinical recovery”, and found a statistically significant difference at p < 0.001: Okay, fine, they misspelled “recovery” once. But they spelled it right the other time! That puts it in the top 50% for ivermectin papers! The fraud-hunters have examined this paper closely and are unable to find any signs of fraud. @PubPeer on the Mahmud trial of ivermectin in covid patients.\n\nI have now reviewed the individual patient data master sheet.\n\nI did not find any irregularities and the summary data matches the published data.\n\n","username":"K_Sheldrick","name":"Kyle Sheldrick","profile_image_url":"","date":"Sat Jul 17 11:06:25 +0000 2021","photos":[],"quoted_tweet":{},"reply_count":0,"retweet_count":2,"like_count":12,"impression_count":0,"expanded_url":{"url":"https://pubpeer.com/publications/E1D65711EF28D14517731BEACB89C8#2","title":"PubPeer - Ivermectin in combination with doxycycline for treating COVI...","description":"There are comments on PubPeer for publication: Ivermectin in combination with doxycycline for treating COVID-19 symptoms: a randomized trial (2021)","domain":"pubpeer.com"},"video_url":null,"belowTheFold":true}" data-component-name="Twitter2ToDOM"> I think this paper is legitimate and that its findings need to be seriously considered. Serious consideration doesn’t always meant they’re true - sometimes if we have strong evidence otherwise we can dismiss things without understanding why. And there’s always the chance it was a fluke, right? Can something have a p-value less than 0.001 and still be a fluke? Szenta Fonseca et al: This is a chart review from Brazil. Researchers looked at various people who had been treated for COVID in an insurance company database, saw whether they got ivermectin or not, and saw whether the people who got it did better or worse. About a hundred people got it, and a few hundred others didn’t. The people who got it did not do any better than anyone else, and you’ll notice this is one of the rare red boxes on the table above. But we shouldn’t take this study seriously. Nobody took any effort to avoid selection bias, so it’s very possible that sicker people were given more medication (including ivermectin), which unfairly handicaps the ivermectin group. Also, it’s hard to tell from the paper who was on how much of what, and the discussion of ivermectin seems like kind of an afterthought after discussing lots of other meds in much more depth. This is another one I feel comfortable ignoring. Cadegiani et al: A crazy person decided to put his patients on every weird medication he could think of, and 585 subjects ended up on a combination of ivermectin, hydroxychloroquine, azithromycin, and nitazoxanide, with dutasteride and spironolactone "optionally offered" and vitamin D, vitamin C, zinc, apixaban, rivaraxoban, enoxaparin, and glucocorticoids "added according to clinical judgment". There was no control group, but the author helpfully designated some random patients in his area as a sort-of-control, and then synthetically generated a second control group based on “a precise estimative based on a thorough and structured review of articles indexed in PubMed and MEDLINE and statements by official government agencies and specific medical societies”. Patients in the experimental group were twice as likely to recover (p < 0.0001), had negative PCR after 14 vs. 21 days, and had 0 vs. 27 hospitalizations. Speaking of low p-values, some people did fraud-detection tests on another of Cadegiani’s COVID-19 studies and got values like p < 8.24E-11 in favor of it being fraudulent. And, uh, he’s also studied whether ultra-high-dose antiandrogens treated COVID, and found that they did, cutting mortality by 92% . But the trial is under suspicion, with a BMJ article calling it “[the worst] violations of medical ethics and human rights in Brazil’s history” and “an ethical cesspit of violations”. [update 2022: this section originally contained more accusations against Cadegiani. Alexandros Marinos does a deeper dive with information not available at the time I wrote this, and finds some of them were overstated or false by implication] Anyway, let’s not base anything important on the results of this study, mmkay? A defiant Flavio Cadegiani. Imagine a guy who looks like this telling you to take ultra-high-dose antiandrogens. Ahmed et al: And we’re back in Bangladesh. 72 hospital patients were randomized to one of three arms: ivermectin only, ivermectin + doxycycline, and placebo. Primary endpoint was time to negative PCR, which was 9.7 days for ivermectin only and 12.7 days for placebo (p = 0.03). Other endpoints including duration of hospitalization (9.6 days ivermectin vs. 9.7 days placebo, not significant). This looks pretty good for ivermectin and does not have any signs of fraud or methodological problems. If I wanted to pick at it anyway, I would point out that the ivermectin + doxycycline group didn’t really differ from placebo, and that if you average out both ivermectin groups (with and without doxycycline) it looks like the difference would not be significant. I had previously committed to considering only ivermectin alone in trials that had multiple ivermectin groups, so I’m not going to do this. I can’t find any evidence this trial was preregistered so I don’t know whether they waited to see what would come out positive and then made that their primary endpoint, but virological clearance is a pretty normal primary endpoint and this isn’t that suspicious. It’s impossible to find any useful commentary on this study because Elgazzar (the guy who ran the most famous fraudulent ivermectin study) had the first name Ahmed, everyone is talking about Elgazzar all the time, and this overwhelms Google whenever I try to search for Ahmed et al. For now I’ll just keep this as a mildly positive and mildly plausible virological clearance result, in the context of no effect on hospitalization length or most symptoms. Chaccour et al: 24 patients in Spain were randomized to receive either medium-dose ivermectin or placebo. The primary outcome was percent of patients with negative PCR at day 7; secondary outcomes were viral load and symptoms. The primary endpoint ended up being kind of a wash - everyone still PCR positive by day 7 so it was impossible to compare groups. Ivermectin trended toward lower viral load but never reached significance. Weirdly, ivermectin did seem to help symptoms, but only anosmia and cough towards the end (p = 0.03), which you would usually think of as lingering post-COVID problems. The paper says: Given these findings, consideration could be given to alternative mechanisms of action different from a direct antiviral effect. One alternative explanation might be a positive allosteric modulation of the nicotinic acetylcholine receptor caused by ivermectin and leading to a downregulation of the ACE-2 receptor and viral entry into the cells of the respiratory epithelium and olfactory bulb. Another mechanism through which ivermectin might influence the reversal of anosmia is by inhibiting the activation of pro-inflammatory pathways in the olfactory epithelium. Inflammation of the olfactory mucosa is thought to play a key role in the development of anosmia in SARS-CoV-2 infection This seems kind of hedge-y. If you’re wondering where things went from there, Dr. Chaccour is now a passionate anti-ivermectin activist: @Finneganporter in @BusinessInsider \n\nThe roots of #ivermectin mania: How South America incubated a fake-medicine craze that took the US by storm\n\n","username":"carlos_chaccour","name":"Dr. Carlos Chaccour ??????","profile_image_url":"","date":"Sun Nov 07 18:40:28 +0000 2021","photos":[],"quoted_tweet":{},"reply_count":0,"retweet_count":2,"like_count":9,"impression_count":0,"expanded_url":{"url":"https://www.businessinsider.in/international/news/the-roots-of-ivermectin-mania-how-south-america-incubated-a-fake-medicine-craze-that-took-the-us-by-storm/articleshow/87554081.cms","image":"https://bucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com/public/images/88d08e70-c9e2-46d4-a5df-96807b6c3a13_2000x1000.jpeg","title":"The roots of ivermectin mania: How South America incubated a fake-medicine craze that took the US by storm","description":"The popularity of unproven anti-parasitic drug ivermectin as a COVID-19 treatment is surging. Its use has roots in South America, where it was hyped by populist","domain":"businessinsider.in"},"video_url":null,"belowTheFold":true}" data-component-name="Twitter2ToDOM"> So I guess he must think of this trial as basically negative, although realistically it’s 24 people and we shouldn’t put too much weight on it either way. Ghauri et al: Pakistan, 95 patients. Nonrandom; the study compared patients who happened to be given ivermectin (along with hydroxychloroquine and azithromycin) vs. patients who were just given the latter two drugs. There’s some evidence this produced systematic differences between the two groups - for example, patients in the control group were 3x more likely to have had diarrhea (this makes sense; diarrhea is a potential ivermectin side effect, so you probably wouldn’t give it to people already struggling with this problem). Also, the control group was twice as likely to be getting corticosteroids, maybe a marker for illness severity. Primary outcome was what percent of both groups had a fever: on day 7 it was 21% of ivermectin patients vs. 65% of controls, p < 0.001. No other outcomes were reported. I don’t hate this study, but I think the nonrandom assignment (and observed systematic differences) is a pretty fatal flaw. I can’t find anyone else talking about this one. At least no one seems to be saying anything bad. Babaloba et al: Be warned: if I have to refer to this one in real-life conversation, I will expand out the “et al” and call it “Babalola & Alakoloko”, because that’s really fun to say. This was a Nigerian RCT comparing 21 patients on low-dose ivermectin, 21 patients on high-dose ivermectin, and 20 patients on a combination of lopinavir and ritonavir, a combination antiviral which later studies found not to work for COVID and which might as well be considered a placebo. Primary outcome, as usual, was days until a negative PCR test. High dose ivermectin was 4.65 days, low dose was 6 days, control was 9.15, p = 0.035. Figure 2 is apparently a photograph of the computer screen where they did this calculation. Gideon Meyerowitz-Katz, part of the team that detects fraud in ivermectin papers, is not a fan of this one: He doesn’t say there what means, but elsewhere he tweets this figure: It’s always a bad sign when your study features in an image with “NUMEROUS IMPOSSIBLE NUMBERS” in red at the top. I think his point is that if you have 21 people, it’s impossible to have 50% of them have headache, because that would be 10.5. If 10 people have a headache, it would be 47.6%; if 11, 52%. So something is clearly wrong here. Seems like a relatively minor mistake, and Meyerowitz-Katz stops short of calling fraud, but it’s not a good look. I’m going to be slightly uncomfortable with this study without rejecting it entirely, and move on. Ravakirti et al: Here we’re in Eastern India - not exactly Bangladesh again, but a stone’s throw away from it. In this RCT patients were randomized into an ivermectin group (57) and a placebo group (58). Primary outcome was negative PCR on day 6, because doing it on day 7 like everyone else would be too easy. As with several other groups, this was a bad move; too few people had it to make a good comparison; it was 13% of intervention vs. 18% of placebo, p = 0.3. Secondary outcomes were also pretty boring, except for the most important: 4 people in the placebo group died, compared to 0 in ivermectin (p = 0.045). On the one hand, this is one outcome of many, reaching the barest significance threshold. Another fluke? Still, there are no real problems with this study, and nobody has anything to say against it. Let’s add this one to the scale as another very small and noisy piece of real evidence in ivermectin’s favor. Bukhari et al: Now we’re in Pakistan. 50 patients were randomized to low-dose ivermectin, another 50 got standard of care including vitamin D. There was no placebo, but primary outcome was number of days to reach negative PCR, which it seems hard for placebo to affect much, so I don’t care. 5 controls and 9 ivermectin patients left the hospital against medical advice and could not be followed up, which is bad but not necessarily study-ruining. They never measured their supposed primary outcome of “days to reach negative PCR” directly, but they did measure how many people had negative PCR on various days, and ivermectin had a clear advantage - for example, on day 7, it was 37/50 for IVR and only 20/50 for control. Even if we assume all the lost-to-followup patients had maximally bad-for-the-hypothesis results, that’s still a positive finding. Nobody else has much to say about this one, certainly no accusations that they’ve found anything suspicious. Keep. Mohan et al: India. RCT. 40 patients got low-dose ivermectin, 40 high-dose ivermectin, and 45 placebo. Primary outcomes were time to negative PCR, and viral load on day 5. In the results, they seem to have reinterpreted “time to negative PCR” as the subtly different “percent with negative PCR on some specific day”. High-dose ivermectin did best (47.5% negative on day 5) and placebo worst (31% negative), but it was insignificant (p = 0.3). There was no difference in viral load. All groups took about the same amount of time for symptoms to resolve. More placebo patients had failed to recover by the end of the study (6) than ivermectin patients (2), but this didn’t reach statistical significance (p = 0.4). Overall a well-done, boring, negative study, although ivermectin proponents will correctly point out that, like basically every other study we have looked at, the trend was in favor of ivermectin and this could potentially end up looking impressive in a meta-analysis. Biber et al: This is an RCT from Israel. 47 patients got ivermectin and 42 placebo. Primary endpoint was viral load on day 6. I am having trouble finding out what happened with this; as far as I can tell it was a negative result and they buried it in favor of more interesting things. In a "multivariable logistic regression model, the adjusted odds ratio of negative SARS-CoV-2 RT-PCR negative test" favored ivermectin over placebo (p = 0.03 for day 6, p = 0.01 for day 8), but this seems like the kind of thing you do when your primary outcome is boring and you’re angry. Gideon Meyerowitz-Katz is not a fan: He notes that the study excluded people with high viral load, but the preregistration didn’t say they would do that. Looking more closely, he finds they did that because, if you included these people, the study got no positive results. So probably they did the study, found no positive results, re-ran it with various subsets of patients until they did get a positive result, and then claimed to have “excluded” patients who weren’t in the subset that worked. I’m going to toss this one. Elalfy et al: What even is this? Where am I? As best I can tell, this is some kind of Egyptian trial. It might or might not be an RCT; it says stuff like “Patients were self-allocated to the treatment groups; the first 3 days of the week for the intervention arm while the other 3 days for symptomatic treatment”. Were they self-allocated in the sense that they got to choose? Doesn’t that mean it’s not random? Aren’t there seven days in a week? These are among the many questions that Elalfy et al do not answer for us. The control group (which they seem to think can also be called “the white group”) took zinc, paracetamol, and maybe azithromycin. The intervention group took zinc, nitazoxanide, ribavirin, and ivermectin. There were very large demographic differences between the groups of the sort which make the study unusable, which they mention and then ignore. From there, they follow this normal and totally comprehensible flowchart: There is no primary outcome assigned, but viral clearance rates on day seven were 58% in the yellow group compared to 0% in the white group, which I guess is a strong positive result. This table… …looks very impressive, in terms of the experimental group doing better than the control, except that they don’t specify whether it was before the trial or after it, and at least one online commentator thinks it might have been before, in which case it’s only impressive how thoroughly they failed to randomize their groups. Overall I don’t feel bad throwing this study out. I hope it one day succeeds in returning to its home planet. Lopez-Medina et al: Colombian RCT. 200 patients took ivermectin, another 200 took placebo. They originally worried the placebo might taste different than real ivermectin, then solved this by replacing it with a different placebo, which is a pretty high level of conscientiousness. Primary outcome was originally percent of patients whose symptoms worsened by two points, as rated on a complicated symptom scale when a researcher asked them over the phone. Halfway through the study, they realized nobody was worsening that much, so they changed the primary outcome to time until symptoms got better, as measured by the scale. In the ivermectin group, symptoms improved that much after 10 days; in the placebo group, after 12, p = 0.53. By the end of the study, symptoms had improved in 82% of ivermectin users and 79% of controls, also insignificant. 4 patients in the ivermectin group needed to be hospitalized compared to 6 in the placebo group, again insignificant. This study is bigger than most of the other RCTs, and more polished in terms of how many spelling errors, photographs of computer screens, etc, it contains. It was published in JAMA, one of the most prestigious US medical journals, as opposed to the crappy nth-tier journals most of the others have been in. When people say things like “sure, a lot of small studies show good results for ivermectin, but the bigger and more professional trials don’t”, this is one of the two big professional trials they’re talking about. Ivermectin proponents make some good arguments against it. In order to get as big as it did, Lopez-Medina had to compromise on rigor. Its outcome is how people self-score their symptoms on a hokey scale in a phone interview, instead of viral load or PCR results or anything like that. Still, this is basically what we want, right? In the end, we want people to feel better and less sick, not to get good scores on PCR tests. Also, it changed its primary outcome halfway through; isn’t that bad? I think maybe not; the reason we want a preregistered primary outcome is so that you don’t change halfway through to whatever outcome shows the results you want. The researchers in this study did a good job explaining why they changed their outcome, the change makes sense, and their original outcome would also have shown ivermectin not working (albeit less accurately and effectively). I don’t know of any evidence that they knew (or suspected) final results when switching to this new outcome, and it seems like the most reasonable new outcome to switch to. Finally, their original placebo tasted different from ivermectin (though they switched halfway through). This is one of the few studies where I actually care about placebo, because people are self-rating their symptoms. But realistically most of these people don’t know what ivermectin is supposed to taste like. Also, they did a re-analysis and found there was no difference between the people who got the old placebo and the new one. I’m making a big deal of this because ivmmeta.com - the really impressive meta-analysis site I’ve been going off of - puts a special warning letter underneath their discussion of this study, urging us not to trust it. They don’t do this for any of the other ones we’ve addressed so far - not the one by the guy whose other studies were all frauds, not the one where 50% of 21 people had headaches, not the unrandomized one where the groups were completely different before the experiment started, not even the one by the guy accused of crimes against humanity. Only this one. This makes me a lot less charitable to ivmmeta than I would otherwise be; I think it’s hard to choose this particular warning letter strategy out of well-intentioned commitment to truth. They just really don’t like this big study that shows ivermectin doesn’t work. Also, the warning itself irritates me, and includes paragraphs like: RCTs have a fundamental bias against finding an effect for interventions that are widely available — patients that believe they need treatment are more likely to decline participation and take the intervention [Yeh], i.e., RCTs are more likely to enroll low-risk participants that do not need treatment to recover (this does not apply to the typical pharmaceutical trial of a new drug that is otherwise unavailable). This trial was run in a community where ivermectin was available OTC and very widely known and used. Nobody else worries about this, and there are a million biases that non-randomized studies have that would be super-relevant when discussing those, but somehow when they’re pro-ivermectin the site forgets to be this thorough. I think a better pro-ivermectin response to this study is to point out that all the trends support ivermectin. Symptoms took 10 days to resolve in the ivermectin group vs. 12 in placebo; 4 ivermectin patients were hospitalized vs. 6 placebo patients, etc. Just say that this was an unusually noisy trial because of the self-report methodology, and you’re confident that these small differences will add up to significance when you put them into a meta-analysis. Roy et al: We’re back in East India, and back to non-randomized trials. 56 patients were retrospectively examined; some had been given ivermectin + doxycycline, others hydroxychloroquine, other azithromycin, and others symptomatic treatment only. We don’t get any meaningful information about how this worked, but we are told that they did not differ in “clinical well-being reporting onset timing”. Whatever. Chahla et al: The first of many Argentine trials. 110 patients received medium-dose ivermectin; 144 were kept as a control (no placebo). This was “cluster randomized”, which means they randomize different health centers to either give the experimental drug or not. This is worse than regular randomization, because there could be differences between these health centers (eg one might have better doctors who otherwise give better treatment, one might be in the poor part of town and have sicker patients, etc). They checked to see if there were any differences between the groups, and it sure looks like there were (the experimental group had twice as many obese people as the controls), but as per them, these differences were not statistically significant. Note that if this did make a difference, it would presumably make ivermectin look worse, not better. The primary outcome was given as “increase discharge from outpatient care with COVID-19 mild disease”. This favored the treatment; only 2/110 patients in the ivermectin group failed to be discharged, compared to 20 patients in the control group. But, uh, these were at different medical centers. Can’t different medical centers just have different discharge policies? One discharges you as soon as you seem to be getting better, the other waits to really make sure? This is an utterly crap endpoint to do a cluster randomized controlled trial on. If you’re going to do cRCT, which is never a great idea, you should be using some extremely objective endpoint that doctors and clinic administrators can’t possibly affect, like viral load according to some third-party laboratory, using the same third-party laboratory for both clinics. This is such a bad idea that I can’t help worrying I’m missing or misunderstanding something. If not, this is dumb and bad and should be ignored. Mourya et al: We’re back in India. This is a nonrandomized study comparing 50 patients given ivermectin to 50 patients given hydroxychloroquine. No primary outcome was named, but they focus on PCR negativity. Only 6% of patients in the hydroxychloroquine group were negative, compared to 90% of patients in the ivermectin group! On what day did they do the test? Uh, kind of random, and they admit that “in [the hydroxychloroquine group], mean time difference from the date of initiation of treatment and second test was significantly longer (7.24±2.75 days) as compared to 5.22±1.21 days in [the ivermectin group] (p=0.021).” Since they assessed these groups at different times, we shouldn’t draw any conclusions from them getting different results. Except that as far as I can tell this should handicap ivermectin, making it especially impressive that it did better. But also, the ivermectin group was made mostly of people who had been asymptomatic at the beginning (70%), and the hydroxychloroquine group had almost no asymptomatic cases (8%) . They were giving the ivermectin to healthy people and the hydroxychloroquine to sick people! They admit deep in the discussion that this “may be a confounding factor”. So basically they got totally different groups of people, tested them at totally different times, and the two sets of test results differed. So what? So this is why normal people do RCTs instead of whatever the heck this is, that’s what. Loue et al: …this one isn’t going to be an RCT either. Loue tells a story about a cluster of COVID cases at the French nursing home where he works. He asked people if they wanted to try ivermectin; 10 did and 15 didn’t. 1 ivermectin patient died, compared to 5 non-ivermectin patients. The non-ivermectin group looked a bit sicker than the ivermectin group in the inevitable Table 1, though it’s hard to tell. One interesting possible confounder (not mentioned, but I’m imagining it) is that demented patients probably couldn’t consent to ivermectin and ended up in the control group. This is another case of “I’m not going to trust anything that isn’t an RCT”. Merino et al: Another (sigh) non-RCT. Mexico City tried a public health program where if you called a hotline and said you had COVID, they sent you an emergency kit with various useful supplies. One of those supplies was ivermectin tablets. 18,074 people got the kit (and presumably some appreciable fraction took the ivermectin, though there’s no way to prove that). Their control group is people from before they started giving out the kits, people from after they stopped giving out the kits, and people who didn’t want the kits. There are differences in who got COVID early in the epidemic vs. later, and in people who did opt for medical kits vs. didn’t. To correct these, the researchers tried to adjust for confounders, something which - as I keep trying to hammer home again and again - never works. They found that using the kit led to a 75% or so reduction in hospitalization, though they were unable to separate out the ivermectin from the other things in the kit (paracetamol and aspirin), or from the placebo effect of having a kit and feeling like you had already gotten some treatment (if I understand right, the decision to go to the hospital was left entirely to the patient). I think this study is a moderate point in favor of giving people kits in order to prevent hospital overcrowding, but I’m not willing to accept that it tells us much about ivermectin in particular. Faisal et al: This one was published in The Professional Medical Journal (mispelled as “Profesional Medical Journal” in its URL), so you know it’s going to be good! It describes itself as “a cross-sectional study”, but later says it “randomized patients into two groups”, which would make it an RCT - I think they might just be using the term “cross-sectional” different from the standard American usage. A hospital in Pakistan got 50 patients on ivermectin + azithromycin, and another 50 on azithromycin alone. Primary outcome was not mentioned, and the data were presented confusingly, but a typical result is that only 4% of the ivermectin group had symptoms lasting more than 10 days, whereas 16% of the control group did, p < 0.01. They do a really weird thing where they compare how long it took symptoms to resolve between IVM and control groups within each bin. That is, if I’m understanding correctly, they ask “of the people who took between 3-5 days for symptoms to resolve, did they resolve faster for IVM or control?”. This is an utterly bizarre analysis to perform, although it doesn’t affect the fact that their other results still seem to favor ivermectin. Maybe I’m confused about what’s going on here. I’ve mostly been letting people off easy on no placebo, but I as far as I can tell (not very far) this paper seems to be going off whether patients reported continuing to have symptoms to the hospital doing the study, and I think that is potentially susceptible to placebo effects. Additionally, there’s no preregistration, and even though they talk a lot about doing PCR tests they don’t present the results. This is by no means the worst study here but I still think it’s pretty low quality and I don’t trust it. Aref et al: This one is published in the International Journal Of Nanomedicine, even though I’m pretty sure that isn’t a real thing. In this case the “nanomedicine” is a new nasal spray version of ivermectin which is so confusing I cannot for the life of me figure out what dose they are giving these patients. This Egyptian study gives 57 patients intranasal ivermectin plus hydroxychloroquine, azithromycin, oseltamavir, and some vitamins; another 57 patients get all that stuff except the ivermectin. Primary outcome is not stated, but they look at various symptoms, all of which look better in the ivermectin group: 95% of ivermectin patients got negative PCRs at some time point, compared to 75% of controls, p = 0.004. I am pretty suspicious of this study, not least because it comes from Egypt which has an awful reputation for fake studies, and it returns extreme results that I wouldn’t expect even if ivermectin was actually a wonder drug. But I cannot find any particular thing wrong with it, nor did anyone else I looked at, so I will grudgingly let it stand. Krolewiecki et al: Another Argentine study. This one is a real RCT. 30 patients received ivermectin, 15 were the control group (no placebo, again). Primary outcome was difference in viral load on day 5. The trend favored ivermectin but it was not statistically significant, although they were able to make it statistically significant if they looked at a subset of higher-IVM-plasma-concentration patients. They did not find any difference in clinical outcomes. A pro-ivermectin person could point out that in the subgroup with the highest ivermectin concentrations, the drug seemed to work. A skeptic could point out that this is exactly the kind of subgroup slicing that you are not supposed to do without pre-registering it, which I don’t think this team did. I agree with the skeptic. Vallejos et al: Another Argentine study. It’s big (250 people in each arm). It’s an RCT. It tries to define a primary outcome (“Primary outcome: the trial ended when the last patient who was included achieved the end of study visit”), but that’s not what “primary outcome” means, and they don’t offer an alternative. Other outcomes: no difference in PCR on days 3 or 12. Hospitalization is nonsignificantly better in the ivermectin group (14 vs. 21, p = 0.2), but death is nonsigificantly better in the placebo group (3 vs. 4, p = 0.7). This isn’t even the kind of nonsignificant that might contribute to an exciting meta-analysis later. This is just a pure null result. I cannot find any problem with this study, and neither can anyone else I checked. This is the biggest RCT we’ve seen so far, so we should take it seriously. TOGETHER Trial: Speaking of big RCTs… This one hasn’t been published yet. There’s a video of a talk about it, but I am not going to watch it, because it is a video, so I am getting information secondhand from eg here. Apparently, it compares 677 people (!) randomized to ivermectin to 678 people randomized to placebo. 86 ivermectin patients ended up in the hospital compared to 95 placebo patients, p-value not significant. This was a really big professional trial done by bigshot researchers from a major Canadian university, and the medical establishment is taking it much more seriously than any of these others. When it comes out, it will probably get published in a top journal. When discussing Lopez-Medina, I wrote: When people say things like “sure, a lot of small studies show good results for ivermectin, but the bigger and more professional trials don’t”, this is one of the two big professional trials they’re talking about. This is the other one. Not coincidentally, it’s also the other trial that ivmmeta.com has a warning letter underneath telling you to disregard. Their main concern is that instead of truly randomizing patients to ivermectin vs. placebo, they did a time-dependent randomization that meant during some weeks more patients were getting one or the other. This is a problem because the trial takes place in Brazil, where different variants were more common at different times. Here’s their image: On the one hand, I have immense contempt for ivmmeta for letting all those other awful studies pass and then pulling out all the stops to try to nitpick this one. I have no idea if their proposed randomization failure really happened. And no doubt the reason they’re even able to investigate this is that this study is really careful and transparent - most of them don’t tell you anything about their randomization method. I would be shocked if other studies don’t have all these problems and worse. On the other hand, the point isn’t to be fair, it’s to be right. And this is a potential confounder. Not a huge one. But a potential one. I guess all we can do is try to bound the damage. Even if the confounding is 100% real and bad, there’s no way to make this study consistent with the crazy super-pro-ivermectin results of studies like Espitia-Hernandez and Aref. And even if we deny any confounding, we see the same slight pro-ivermectin trend - 86 hospitalizations vs. 95 - that we’ve seen in so many other studies. Nothing is going to make me believe that this isn’t in the top 33% of studies we’ve been looking at, so let’s add it as grist for the meta-analysis (though maybe not quite as much grist as its vast size indicates) and move on, angrily. Buonfrate et al: An Italian RCT. Patients were randomized into low-dose ivermectin (32), placebo (29), or high-dose ivermectin (32). Primary outcome was viral load on day 7. There was no significant difference (average of 2 in ivermectin groups, 2.2 in placebo group). They admit that they failed to reach the planned sample size, but did a calculation to show that even if they had, the trial could not have returned a positive result. Clinically, an average of 2 patients were hospitalized in each of the ivermectin arms, compared to 0 in the placebo arm - which bucks our previously-very-constant pro-ivermectin trend. Mayer et al: Not an RCT. Patients in an Argentine province were offered the opportunity to try ivermectin; 3266 said yes and become the experimental group, 17966 said no and became the control group. There were many obvious differences between the groups, but they all seemed to handicap ivermectin. There was a nonsignificant trend toward less hospitalization and significantly less mortality (1.5% vs. 2.1%, p = 0.03). While looking into this study, I learned the term “immortal time bias”. This means a period in between selection for the study and the beginning of study recording where patient outcomes are not counted. I think the problem here is that if you signed up for the system on Day X, and if you got sick before they could give you ivermectin, you were in the control group. See this Twitter thread, I have not confirmed everything he says. This only hardens my resolve to stay away from non-RCTs. Borody et al: Our last paper! …is it a paper? I can’t find it published anywhere. It mostly seems to be on news sites. Doesn’t look peer-reviewed. And it starts with “Note that views expressed in this opinion article are the writer’s personal views”. Whatever. 600 Australians were treated with ivermectin, doxycycline, and zinc. The article compares this to an “equivalent control group” made of “contemporary infected subjects in Australia obtained from published Covid Tracking Data”; this is not how you control group, @#!% you. Then it gets excited about the fact that most patients had better symptoms at the end of the ten-day study period than the beginning (untreated COVID resolves in about ten days). Why are these people wasting my time with this? Let’s move on. The Analysis If we remove all fraudulent and methodologically unsound studies from the table above, we end up with this: Gideon Meyerowitz-Katz, who investigated many of the studies above for fraud, tried a similar exercise. I learned about his halfway through, couldn’t help seeing it briefly, but tried to avoid remembering it or using it when generating mine (also, I did take the result of his fraud investigations into account), so they should be considered not quite independent efforts. His looks like this: He nixed Chowdhury, Babaloba, Ghauri, Faisal, and Aref, but kept Szenta Fonseca, Biber (?), and Mayer. There was correlation of 0.45, which I guess is okay. I asked him about his decision-making, and he listed a combination of serious statistical errors and small red flags adding up. I was pretty uncomfortable with most of these studies myself, so I will err on the side of severity, and remove all studies that either I or Meyerowitz-Katz disliked. We end up with the following short list: We’ve gone from 29 studies to 11, getting rid of 18 along the way. For the record, we eliminated 2/19 for fraud, 1/19 for severe preregistration violations, 10 for methodological problems, and 6 because Meyerowitz-Katz was suspicious of them. …but honestly this table still looks pretty good for ivermectin, doesn’t it? Still lots of big green boxes. Meyerowitz-Katz accuses ivmmeta of cherry-picking what statistic to use for their forest plot. That is, if a study measures ten outcomes, they sometimes take the most pro-ivermectin outcome. Ivmmeta.com counters that they used a consistent and reasonable (if complicated) process for choosing their outcome of focus, that being: If studies report multiple kinds of effects then the most serious outcome is used in calculations for that study. For example, if effects for mortality and cases are both reported, the effect for mortality is used, this may be different to the effect that a study focused on. If symptomatic results are reported at multiple times, we used the latest time, for example if mortality results are provided at 14 days and 28 days, the results at 28 days are used. Mortality alone is preferred over combined outcomes. Outcomes with zero events in both arms were not used (the next most serious outcome is used — no studies were excluded). For example, in low-risk populations with no mortality, a reduction in mortality with treatment is not possible, however a reduction in hospitalization, for example, is still valuable. Clinical outcome is considered more important than PCR testing status. When basically all patients recover in both treatment and control groups, preference for viral clearance and recovery is given to results mid-recovery where available (after most or all patients have recovered there is no room for an effective treatment to do better). If only individual symptom data is available, the most serious symptom has priority, for example difficulty breathing or low SpO2 is more important than cough. I’m having trouble judging this, partly because Meyerowitz-Katz says ivmmeta has corrected some earlier mistakes, and partly because there really is some reasonable debate over how to judge studies with lots of complicated endpoints. By this point I had completely forgotten what ivmmeta did, so I independently coded all 11 remaining studies following something in between my best understanding of their procedure and what I considered common sense. The only exception was that when the most severe outcome was measured in something other than patients (ie average number of virus copies per patient), I defaulted to one that was measured in patients instead, to keep everything with the same denominator. My results mostly matched ivmmeta’s, with one or two exceptions that I think are within the scope of argument or related to my minor deviations from their protocol. Placebo vs. ivermectin groups sometimes differed in size, which I’ve adjusted for and rounded off. Probably I’m forgetting some reason I can’t just do simple summary statistics to this, but whatever. It is p = 0.15, not significant. This is maybe unfair, because there aren’t a lot of deaths in the sample, so by focusing on death rather than more common outcomes we’re pointlessly throwing away sample size. What happens if I unprincipledly pick whatever I think the most reasonable outcome to use from each study is? I’ve chosen “most reasonable” as a balance between “is the most severe” and “has a lot of data points”: Now it’s p = 0.04, seemingly significant, but I had to make some unprincipled decisions to get there. I don’t think I specifically replaced negative findings with positive ones, but I can’t prove that even to myself, let alone to you. [UPDATE 5/31/22: A reader writes in to tell me that the t-test I used above is overly simplistic. A Dersimonian-Laird test is more appropriate for meta-analysis, and would have given 0.03 and 0.005 on the first and second analysis, where I got 0.15 and 0.04. This significantly strengthens the apparent benefit of ivermectin from ‘debatable’ to ‘clear’. I discuss some reasons below why I am not convinced by this apparent benefit.] (how come I’m finding a bunch of things on the edge of significance, but the original ivmmeta site found a lot of extremely significant things? Because they combined ratios, such that “one death in placebo, zero in ivermectin” looked like a nigh-infinite benefit for ivermectin, whereas I’m combining raw numbers. Possibly my way is statistically illegitimate for some reason, but I’m just trying to get a rough estimate of how convinced to be) So we are stuck somewhere between “nonsignificant trend in favor” and “maybe-significant trend in favor, after throwing out some best practices”. This is normally where I would compare my results to those of other meta-analyses made by real professionals. But when I look at them, they all include studies later found to be fake, like Elgazzar, and unsurprisingly come up with wildly positive conclusions. There are about six in this category. One of them later revised their results to exclude Elgazzar and still found strong efficacy for ivermectin, but they still included Niaee and some other dubious studies. The only meta-analysis that doesn’t make these mistakes is Popp (a Cochrane review), which is from before Elgazzar was found to be fraudulent, but coincidentally excludes it for other reasons. It also excludes a lot of good studies like Mahmud and Ravakirti because they give patients other things like HCQ and azithromycin - I chose to include them, because I don’t think they either work or have especially bad side effects, so they’re basically placebo - but Cochrane is always harsh like this. They end up with a point estimate where ivermectin cuts mortality by 40% - but say the confidence intervals are too wide to draw any conclusion. I think this basically agrees with my analyses above - the trends really are in ivermectin’s favor, but once you eliminate all the questionable studies there are too few studies left to have enough statistical power to reach significance. Except that everyone is still focusing on deaths and hospitalizations just because they’re flashy. Mahmud et al, which everyone agrees is a great study, found that ivermectin decreased days until clinical recovery, p = 0.003? So what do you do? This is one of the toughest questions in medicine. It comes up again and again. You have some drug. You read some studies. Again and again, more people are surviving (or avoiding complications) when they get the drug. It’s a pattern strong enough to common-sensically notice. But there isn’t an undeniable, unbreachable fortress of evidence. The drug is really safe and doesn’t have a lot of side effects. So do you give it to your patients? Do you take it yourself? Here this question is especially tough, because, uh, if you say anything in favor of ivermectin you will be cast out of civilization and thrown into the circle of social hell reserved for Klan members and 1/6 insurrectionists. All the health officials in the world will shout “horse dewormer!” at you and compare you to Josef Mengele. But good doctors aren’t supposed to care about such things. Your only goal is to save your patient. Nothing else matters. I am telling you that Mahmud et al is a good study and it got p = 0.003 in favor of ivermectin. You can take the blue pill, and stay a decent respectable member of society. Or you can take the horse dewormer pill, and see where you end up. In a second, I’ll tell you my answer. But you won’t always have me to answer questions like this, and it might be morally edifying to observe your thought process in situations like this. So take a second, and meet me on the other side of the next section heading. … … … … … The Synthesis Hopefully you learned something interesting about yourself there. But my answer is: worms! As several doctors and researchers have pointed out (h/t especially Avi Bitterman and David Boulware), the most impressive studies come from places that are teeming with worms. Mahmud from Bangladesh, Ravakirti from East India, Lopez-Medina from Colombia, etc. Here’s the prevalence of roundworm infections by country (source). But alongside roundworms, there are threadworms, hookworms, blood flukes, liver flukes, nematodes, trematodes, all sorts of worms. Add them all up and somewhere between half and a quarter of people in the developing world have at least one parasitic worm in their body. Being full of worms may impact your ability to fight coronavirus. Gluchowska et al write: Helminth [ie worm] infections are among the most common infectious diseases. Bradbury et al. highlight the possible negative interactions between helminth infection and COVID-19 severity in helminth-endemic regions and note that alterations in the gut microbiome associated with helminth infection appear to have systemic immunomodulatory effects. It has also been proposed that helminth co-infection may increase the morbidity and mortality of COVID-19, because the immune system cannot efficiently respond to the virus; in addition, vaccines will be less effective for these patients, but treatment and prevention of helminth infections might reduce the negative effect of COVID-19. During millennia of parasite-host coevolution helminths evolved mechanisms suppressing the host immune responses, which may mitigate vaccine efficacy and increase severity of other infectious diseases. Treatment of worm infections might reduce the negative effect of COVID-19! And ivermectin is a deworming drug! You can see where this is going… The most relevant species of worm here is the roundworm Strongyloides stercoralis. Among the commonest treatments for COVID-19 is corticosteroids, a type of immunosuppresant drug. The types of immune responses it suppresses do more harm than good in coronavirus, so turning them off limits collateral damage and makes patients better on net. But these are also the types of immune responses that control Strongyloides. If you turn them off even very briefly, the worms multiply out of control, you get what’s called “Strongyloides hyperinfection”, and pretty often you die. According to the WHO: The current COVID-19 pandemic serves to highlight the risk of using systemic corticosteroids and, to a lesser extent, other immunosuppressive therapy, in populations with significant risk of underlying strongyloidiasis. Cases of strongyloidiasis hyperinfection in the setting of corticosteroid use as COVID-19 therapy have been described and draw attention to the necessity of addressing the risk of iatrogenic strongyloidiasis hyperinfection syndrome in infected individuals prior to corticosteroid administration. Although this has gained importance in the midst of a pandemic where corticosteroids are one of few therapies shown to improve mortality, its relevance is much broader given that corticosteroids and other immunosuppressive therapies have become increasingly common in treatment of chronic diseases (e.g. asthma or certain rheumatologic conditions). So you need to “address the risk” of strongyloides infection during COVID treatment in roundworm-endemic areas. And how might you address this, WHO? Treatment of chronic strongyloidiasis with ivermectin 200 µg/kg per day orally x 1-2 days is considered safe with potential contraindications including possible Loa loa infection (endemic in West and Central Africa), pregnancy, and weight <15kg. Given ivermectin’s safety profile, the United States has utilized presumptive treatment with ivermectin for strongyloidiasis in refugees resettling from endemic areas, and both Canada and the European Centre for Disease Prevention and Control have issued guidance on presumptive treatment to avoid hyperinfection in at risk populations. Screening and treatment, or where not available, addition of ivermectin to mass drug administration programs should be studied and considered. This is serious and common enough that, if you’re not going to screen for it, it might be worth “add[ing] ivermectin to mass drug administration programs” in affected areas! Dr. Avi Bitterman carries the hypothesis to the finish line: First two images are with all relevant studies; second two are a sensitivity analysis that removes some of the most dubious. The good ivermectin trials in areas with low Strongyloides prevalence, like Vallejos in Argentina, are mostly negative. The good ivermectin trials in areas with high Strongyloides prevalence, like Mahmud in Bangladesh, are mostly positive. Worms can’t explain the viral positivity outcomes (ie PCR), but Dr. Bitterman suggests that once you remove low quality trials and worm-related results, the rest looks like simple publication bias: This is still just a possibility. Maybe I’m over-focusing too hard on a couple positive results and this will all turn out to be nothing. Or who knows, maybe ivermectin does work against COVID a little - although it would have to be very little, fading to not at all in temperate worm-free countries. But this theory feels right to me. It feels right to me because it’s the most troll-ish possible solution. Everybody was wrong! The people who called it a miracle drug against COVID were wrong. The people who dismissed all the studies because they F@#king Love Science were wrong. Ivmmeta.com was wrong. Gideon Meyerowitz-Katz was…well, he was right, actually, I got the worm-related meta-analysis graphic above from his Twitter timeline. Still, an excellent troll. Also, the best part is that I ignorantly asked, in my description of Mahmud et al above: And it was! It was a fluke! A literal, physical, fluke! For my whole life, God has been placing terrible puns in my path to irritate me, and this would be the worst one ever! So it has to be true! The Scientific Takeaway About ten years ago, when the replication crisis started, we learned a certain set of tools for examining studies. Check for selection bias. Distrust “adjusting for confounders”. Check for p-hacking and forking paths. Make teams preregister their analyses. Do forest plots to find publication bias. Stop accepting p-values of 0.049. Wait for replications. Trust reviews and meta-analyses, instead of individual small studies. These were good tools. Having them was infinitely better than not having them. But even in 2014, I was writing about how many bad studies seemed to slip through the cracks even when we pushed this toolbox to its limits. We needed new tools. I think the methods that Meyerowitz-Katz, Sheldrake, Heathers, Brown, Lawrence and others brought to the limelight this year are some of the new tools we were waiting for. Part of this new toolset is to check for fraud. About 10 - 15% of the seemingly-good studies on ivermectin ended up extremely suspicious for fraud. Elgazzar, Carvallo, Niaee, Cadegiani, Samaha. There are ways to check for this even when you don’t have the raw data. Like: The Carlisle-Stouffer-Fisher method: Check some large group of comparisons, usually the Table 1 of an RCT where they compare the demographic characteristics of the control and experimental groups, for reasonable p-values. Real data will have p-values all over the map; one in every ten comparisons will have a p-value of 0.1 or less. Fakers seem bad at this and usually give everything a nice safe p-value like 0.8 or 0.9.
Inline links: Elgazzar et al:, here, Chowdury et al, Espitia-Hernandez et al:, deviated from its preregistration, https://substackcdn.com/image/fetch/$s_!nJOk!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2Fda0f378f-c7e9-446c-909b-b870b062fd39_589x444.png, Carvallo et al:, another Carvallo paper was retracted, Mahmud et al:, https://substackcdn.com/image/fetch/$s_!ST60!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F1ff4783b-1473-4413-9230-8b15a5549208_500x469.gif, Szenta Fonseca et al:, Cadegiani et al:, a BMJ article, a deeper dive, https://substackcdn.com/image/fetch/$s_!ARca!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F7fe429e5-dba6-4b59-b46f-a2345b6acaf4_1080x720.jpeg, Ahmed et al:, Chaccour et al:, Ghauri et al:, Babaloba et al:, https://substackcdn.com/image/fetch/$s_!f598!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F0238280a-236e-47f5-9db6-7c35c07c5fc2_520x393.jpeg, https://substackcdn.com/image/fetch/$s_!SRpb!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2Fb5271fbd-b82a-4e34-9787-8b3aa6e8d2f6_595x522.png, https://substackcdn.com/image/fetch/$s_!cKHm!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2Ff9be5d50-858b-4c3a-bef7-a312df762eda_638x549.png, Ravakirti et al:, Bukhari et al:, Mohan et al:, Biber et al:, the preregistration, Elalfy et al:, https://substackcdn.com/image/fetch/$s_!B_IH!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F4d3559ee-a058-44cc-9b38-09b78a0f5035_1352x1070.png, https://substackcdn.com/image/fetch/$s_!9mI_!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2Fbffceed7-c84a-45c1-abfe-1fb2706dc383_483x674.png, Lopez-Medina et al:, Roy et al:, Chahla et al:, Mourya et al:, Loue et al:, Table 1, Merino et al:, never works, Faisal et al:, Aref et al:, https://substackcdn.com/image/fetch/$s_!-FoK!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2Ff6de79b6-091b-4c13-b7be-715c9bb194a7_986x810.jpeg, Krolewiecki et al:, Vallejos et al:, TOGETHER Trial:, here, https://substackcdn.com/image/fetch/$s_!7X0m!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F1f65fd44-58b9-4489-a934-02a5a7330499_706x768.png, Buonfrate et al:, Mayer et al:, immortal time bias, this Twitter thread, Borody et al:, https://substackcdn.com/image/fetch/$s_!Wpjs!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F2d8a451b-b1fc-44e5-ae67-b1506e491762_914x657.png, https://substackcdn.com/image/fetch/$s_!DOjA!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F17d5827a-38da-4a99-beb3-c3018df5c633_920x604.png, https://substackcdn.com/image/fetch/$s_!GX1n!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2Fc692fec8-a450-4579-b337-c72bec060970_912x298.png, https://substackcdn.com/image/fetch/$s_!YcH4!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2Ff36db98e-e653-44da-906c-20312b1689a3_468x205.png, https://substackcdn.com/image/fetch/$s_!jbcL!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2Fd189a844-daf2-4199-bb2e-830d4fc64415_468x206.png, later revised their results to exclude Elgazzar, Popp, https://substackcdn.com/image/fetch/$s_!2B6r!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F505c5ac4-3fe8-47a4-8505-dab80601b44d_416x198.png, Avi Bitterman, David Boulware, https://substackcdn.com/image/fetch/$s_!JWWh!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2Fac9e4f34-f9cc-40f2-9d83-da4e7178fad7_772x330.png, source, Gluchowska et al, the WHO, carries, https://substackcdn.com/image/fetch/$s_!xExE!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F5da21781-249c-4e59-b616-9f23d83cc044_2048x1184.jpeg, https://substackcdn.com/image/fetch/$s_!4SMr!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2Fdcd6e4b2-37f7-4602-93d5-2581c3b27a60_700x432.png, https://substackcdn.com/image/fetch/$s_!-6n2!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F7fd6e8f4-093e-4e02-bce7-363615146c9c_2228x1346.jpeg, https://substackcdn.com/image/fetch/$s_!CPZs!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2Fb0425847-198a-4bd3-a63b-149f15d147ba_700x432.png, https://substackcdn.com/image/fetch/$s_!H3rK!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F9972491b-25b0-4c06-8aca-86fce102ae63_666x147.png, even in 2014, The Carlisle-Stouffer-Fisher method
It’s always a bad sign when your study features in an image with “NUMEROUS IMPOSSIBLE NUMBERS” in red at the top. I think his point is that if you have 21 people, it’s impossible to have 50% of them have headache, because that would be 10.5. If 10 people have a headache, it would be 47.6%; if 11, 52%. So something is clearly wrong here. Seems like a relatively minor mistake, and Meyerowitz-Katz stops short of calling fraud, but it’s not a good look. I’m going to be slightly uncomfortable with this study without rejecting it entirely, and move on. Ravakirti et al: Here we’re in Eastern India - not exactly Bangladesh again, but a stone’s throw away from it. In this RCT patients were randomized into an ivermectin group (57) and a placebo group (58). Primary outcome was negative PCR on day 6, because doing it on day 7 like everyone else would be too easy. As with several other groups, this was a bad move; too few people had it to make a good comparison; it was 13% of intervention vs. 18% of placebo, p = 0.3. Secondary outcomes were also pretty boring, except for the most important: 4 people in the placebo group died, compared to 0 in ivermectin (p = 0.045). On the one hand, this is one outcome of many, reaching the barest significance threshold. Another fluke? Still, there are no real problems with this study, and nobody has anything to say against it. Let’s add this one to the scale as another very small and noisy piece of real evidence in ivermectin’s favor. Bukhari et al: Now we’re in Pakistan. 50 patients were randomized to low-dose ivermectin, another 50 got standard of care including vitamin D. There was no placebo, but primary outcome was number of days to reach negative PCR, which it seems hard for placebo to affect much, so I don’t care. 5 controls and 9 ivermectin patients left the hospital against medical advice and could not be followed up, which is bad but not necessarily study-ruining. They never measured their supposed primary outcome of “days to reach negative PCR” directly, but they did measure how many people had negative PCR on various days, and ivermectin had a clear advantage - for example, on day 7, it was 37/50 for IVR and only 20/50 for control. Even if we assume all the lost-to-followup patients had maximally bad-for-the-hypothesis results, that’s still a positive finding. Nobody else has much to say about this one, certainly no accusations that they’ve found anything suspicious. Keep. Mohan et al: India. RCT. 40 patients got low-dose ivermectin, 40 high-dose ivermectin, and 45 placebo. Primary outcomes were time to negative PCR, and viral load on day 5. In the results, they seem to have reinterpreted “time to negative PCR” as the subtly different “percent with negative PCR on some specific day”. High-dose ivermectin did best (47.5% negative on day 5) and placebo worst (31% negative), but it was insignificant (p = 0.3). There was no difference in viral load. All groups took about the same amount of time for symptoms to resolve. More placebo patients had failed to recover by the end of the study (6) than ivermectin patients (2), but this didn’t reach statistical significance (p = 0.4). Overall a well-done, boring, negative study, although ivermectin proponents will correctly point out that, like basically every other study we have looked at, the trend was in favor of ivermectin and this could potentially end up looking impressive in a meta-analysis. Biber et al: This is an RCT from Israel. 47 patients got ivermectin and 42 placebo. Primary endpoint was viral load on day 6. I am having trouble finding out what happened with this; as far as I can tell it was a negative result and they buried it in favor of more interesting things. In a "multivariable logistic regression model, the adjusted odds ratio of negative SARS-CoV-2 RT-PCR negative test" favored ivermectin over placebo (p = 0.03 for day 6, p = 0.01 for day 8), but this seems like the kind of thing you do when your primary outcome is boring and you’re angry. Gideon Meyerowitz-Katz is not a fan: He notes that the study excluded people with high viral load, but the preregistration didn’t say they would do that. Looking more closely, he finds they did that because, if you included these people, the study got no positive results. So probably they did the study, found no positive results, re-ran it with various subsets of patients until they did get a positive result, and then claimed to have “excluded” patients who weren’t in the subset that worked. I’m going to toss this one. Elalfy et al: What even is this? Where am I? As best I can tell, this is some kind of Egyptian trial. It might or might not be an RCT; it says stuff like “Patients were self-allocated to the treatment groups; the first 3 days of the week for the intervention arm while the other 3 days for symptomatic treatment”. Were they self-allocated in the sense that they got to choose? Doesn’t that mean it’s not random? Aren’t there seven days in a week? These are among the many questions that Elalfy et al do not answer for us. The control group (which they seem to think can also be called “the white group”) took zinc, paracetamol, and maybe azithromycin. The intervention group took zinc, nitazoxanide, ribavirin, and ivermectin. There were very large demographic differences between the groups of the sort which make the study unusable, which they mention and then ignore. From there, they follow this normal and totally comprehensible flowchart: There is no primary outcome assigned, but viral clearance rates on day seven were 58% in the yellow group compared to 0% in the white group, which I guess is a strong positive result. This table… …looks very impressive, in terms of the experimental group doing better than the control, except that they don’t specify whether it was before the trial or after it, and at least one online commentator thinks it might have been before, in which case it’s only impressive how thoroughly they failed to randomize their groups. Overall I don’t feel bad throwing this study out. I hope it one day succeeds in returning to its home planet. Lopez-Medina et al: Colombian RCT. 200 patients took ivermectin, another 200 took placebo. They originally worried the placebo might taste different than real ivermectin, then solved this by replacing it with a different placebo, which is a pretty high level of conscientiousness. Primary outcome was originally percent of patients whose symptoms worsened by two points, as rated on a complicated symptom scale when a researcher asked them over the phone. Halfway through the study, they realized nobody was worsening that much, so they changed the primary outcome to time until symptoms got better, as measured by the scale. In the ivermectin group, symptoms improved that much after 10 days; in the placebo group, after 12, p = 0.53. By the end of the study, symptoms had improved in 82% of ivermectin users and 79% of controls, also insignificant. 4 patients in the ivermectin group needed to be hospitalized compared to 6 in the placebo group, again insignificant. This study is bigger than most of the other RCTs, and more polished in terms of how many spelling errors, photographs of computer screens, etc, it contains. It was published in JAMA, one of the most prestigious US medical journals, as opposed to the crappy nth-tier journals most of the others have been in. When people say things like “sure, a lot of small studies show good results for ivermectin, but the bigger and more professional trials don’t”, this is one of the two big professional trials they’re talking about. Ivermectin proponents make some good arguments against it. In order to get as big as it did, Lopez-Medina had to compromise on rigor. Its outcome is how people self-score their symptoms on a hokey scale in a phone interview, instead of viral load or PCR results or anything like that. Still, this is basically what we want, right? In the end, we want people to feel better and less sick, not to get good scores on PCR tests. Also, it changed its primary outcome halfway through; isn’t that bad? I think maybe not; the reason we want a preregistered primary outcome is so that you don’t change halfway through to whatever outcome shows the results you want. The researchers in this study did a good job explaining why they changed their outcome, the change makes sense, and their original outcome would also have shown ivermectin not working (albeit less accurately and effectively). I don’t know of any evidence that they knew (or suspected) final results when switching to this new outcome, and it seems like the most reasonable new outcome to switch to. Finally, their original placebo tasted different from ivermectin (though they switched halfway through). This is one of the few studies where I actually care about placebo, because people are self-rating their symptoms. But realistically most of these people don’t know what ivermectin is supposed to taste like. Also, they did a re-analysis and found there was no difference between the people who got the old placebo and the new one. I’m making a big deal of this because ivmmeta.com - the really impressive meta-analysis site I’ve been going off of - puts a special warning letter underneath their discussion of this study, urging us not to trust it. They don’t do this for any of the other ones we’ve addressed so far - not the one by the guy whose other studies were all frauds, not the one where 50% of 21 people had headaches, not the unrandomized one where the groups were completely different before the experiment started, not even the one by the guy accused of crimes against humanity. Only this one. This makes me a lot less charitable to ivmmeta than I would otherwise be; I think it’s hard to choose this particular warning letter strategy out of well-intentioned commitment to truth. They just really don’t like this big study that shows ivermectin doesn’t work. Also, the warning itself irritates me, and includes paragraphs like: RCTs have a fundamental bias against finding an effect for interventions that are widely available — patients that believe they need treatment are more likely to decline participation and take the intervention [Yeh], i.e., RCTs are more likely to enroll low-risk participants that do not need treatment to recover (this does not apply to the typical pharmaceutical trial of a new drug that is otherwise unavailable). This trial was run in a community where ivermectin was available OTC and very widely known and used. Nobody else worries about this, and there are a million biases that non-randomized studies have that would be super-relevant when discussing those, but somehow when they’re pro-ivermectin the site forgets to be this thorough. I think a better pro-ivermectin response to this study is to point out that all the trends support ivermectin. Symptoms took 10 days to resolve in the ivermectin group vs. 12 in placebo; 4 ivermectin patients were hospitalized vs. 6 placebo patients, etc. Just say that this was an unusually noisy trial because of the self-report methodology, and you’re confident that these small differences will add up to significance when you put them into a meta-analysis. Roy et al: We’re back in East India, and back to non-randomized trials. 56 patients were retrospectively examined; some had been given ivermectin + doxycycline, others hydroxychloroquine, other azithromycin, and others symptomatic treatment only. We don’t get any meaningful information about how this worked, but we are told that they did not differ in “clinical well-being reporting onset timing”. Whatever. Chahla et al: The first of many Argentine trials. 110 patients received medium-dose ivermectin; 144 were kept as a control (no placebo). This was “cluster randomized”, which means they randomize different health centers to either give the experimental drug or not. This is worse than regular randomization, because there could be differences between these health centers (eg one might have better doctors who otherwise give better treatment, one might be in the poor part of town and have sicker patients, etc). They checked to see if there were any differences between the groups, and it sure looks like there were (the experimental group had twice as many obese people as the controls), but as per them, these differences were not statistically significant. Note that if this did make a difference, it would presumably make ivermectin look worse, not better. The primary outcome was given as “increase discharge from outpatient care with COVID-19 mild disease”. This favored the treatment; only 2/110 patients in the ivermectin group failed to be discharged, compared to 20 patients in the control group. But, uh, these were at different medical centers. Can’t different medical centers just have different discharge policies? One discharges you as soon as you seem to be getting better, the other waits to really make sure? This is an utterly crap endpoint to do a cluster randomized controlled trial on. If you’re going to do cRCT, which is never a great idea, you should be using some extremely objective endpoint that doctors and clinic administrators can’t possibly affect, like viral load according to some third-party laboratory, using the same third-party laboratory for both clinics. This is such a bad idea that I can’t help worrying I’m missing or misunderstanding something. If not, this is dumb and bad and should be ignored. Mourya et al: We’re back in India. This is a nonrandomized study comparing 50 patients given ivermectin to 50 patients given hydroxychloroquine. No primary outcome was named, but they focus on PCR negativity. Only 6% of patients in the hydroxychloroquine group were negative, compared to 90% of patients in the ivermectin group! On what day did they do the test? Uh, kind of random, and they admit that “in [the hydroxychloroquine group], mean time difference from the date of initiation of treatment and second test was significantly longer (7.24±2.75 days) as compared to 5.22±1.21 days in [the ivermectin group] (p=0.021).” Since they assessed these groups at different times, we shouldn’t draw any conclusions from them getting different results. Except that as far as I can tell this should handicap ivermectin, making it especially impressive that it did better. But also, the ivermectin group was made mostly of people who had been asymptomatic at the beginning (70%), and the hydroxychloroquine group had almost no asymptomatic cases (8%) . They were giving the ivermectin to healthy people and the hydroxychloroquine to sick people! They admit deep in the discussion that this “may be a confounding factor”. So basically they got totally different groups of people, tested them at totally different times, and the two sets of test results differed. So what? So this is why normal people do RCTs instead of whatever the heck this is, that’s what. Loue et al: …this one isn’t going to be an RCT either. Loue tells a story about a cluster of COVID cases at the French nursing home where he works. He asked people if they wanted to try ivermectin; 10 did and 15 didn’t. 1 ivermectin patient died, compared to 5 non-ivermectin patients. The non-ivermectin group looked a bit sicker than the ivermectin group in the inevitable Table 1, though it’s hard to tell. One interesting possible confounder (not mentioned, but I’m imagining it) is that demented patients probably couldn’t consent to ivermectin and ended up in the control group. This is another case of “I’m not going to trust anything that isn’t an RCT”. Merino et al: Another (sigh) non-RCT. Mexico City tried a public health program where if you called a hotline and said you had COVID, they sent you an emergency kit with various useful supplies. One of those supplies was ivermectin tablets. 18,074 people got the kit (and presumably some appreciable fraction took the ivermectin, though there’s no way to prove that). Their control group is people from before they started giving out the kits, people from after they stopped giving out the kits, and people who didn’t want the kits. There are differences in who got COVID early in the epidemic vs. later, and in people who did opt for medical kits vs. didn’t. To correct these, the researchers tried to adjust for confounders, something which - as I keep trying to hammer home again and again - never works. They found that using the kit led to a 75% or so reduction in hospitalization, though they were unable to separate out the ivermectin from the other things in the kit (paracetamol and aspirin), or from the placebo effect of having a kit and feeling like you had already gotten some treatment (if I understand right, the decision to go to the hospital was left entirely to the patient). I think this study is a moderate point in favor of giving people kits in order to prevent hospital overcrowding, but I’m not willing to accept that it tells us much about ivermectin in particular. Faisal et al: This one was published in The Professional Medical Journal (mispelled as “Profesional Medical Journal” in its URL), so you know it’s going to be good! It describes itself as “a cross-sectional study”, but later says it “randomized patients into two groups”, which would make it an RCT - I think they might just be using the term “cross-sectional” different from the standard American usage. A hospital in Pakistan got 50 patients on ivermectin + azithromycin, and another 50 on azithromycin alone. Primary outcome was not mentioned, and the data were presented confusingly, but a typical result is that only 4% of the ivermectin group had symptoms lasting more than 10 days, whereas 16% of the control group did, p < 0.01. They do a really weird thing where they compare how long it took symptoms to resolve between IVM and control groups within each bin. That is, if I’m understanding correctly, they ask “of the people who took between 3-5 days for symptoms to resolve, did they resolve faster for IVM or control?”. This is an utterly bizarre analysis to perform, although it doesn’t affect the fact that their other results still seem to favor ivermectin. Maybe I’m confused about what’s going on here. I’ve mostly been letting people off easy on no placebo, but I as far as I can tell (not very far) this paper seems to be going off whether patients reported continuing to have symptoms to the hospital doing the study, and I think that is potentially susceptible to placebo effects. Additionally, there’s no preregistration, and even though they talk a lot about doing PCR tests they don’t present the results. This is by no means the worst study here but I still think it’s pretty low quality and I don’t trust it. Aref et al: This one is published in the International Journal Of Nanomedicine, even though I’m pretty sure that isn’t a real thing. In this case the “nanomedicine” is a new nasal spray version of ivermectin which is so confusing I cannot for the life of me figure out what dose they are giving these patients. This Egyptian study gives 57 patients intranasal ivermectin plus hydroxychloroquine, azithromycin, oseltamavir, and some vitamins; another 57 patients get all that stuff except the ivermectin. Primary outcome is not stated, but they look at various symptoms, all of which look better in the ivermectin group: 95% of ivermectin patients got negative PCRs at some time point, compared to 75% of controls, p = 0.004. I am pretty suspicious of this study, not least because it comes from Egypt which has an awful reputation for fake studies, and it returns extreme results that I wouldn’t expect even if ivermectin was actually a wonder drug. But I cannot find any particular thing wrong with it, nor did anyone else I looked at, so I will grudgingly let it stand. Krolewiecki et al: Another Argentine study. This one is a real RCT. 30 patients received ivermectin, 15 were the control group (no placebo, again). Primary outcome was difference in viral load on day 5. The trend favored ivermectin but it was not statistically significant, although they were able to make it statistically significant if they looked at a subset of higher-IVM-plasma-concentration patients. They did not find any difference in clinical outcomes. A pro-ivermectin person could point out that in the subgroup with the highest ivermectin concentrations, the drug seemed to work. A skeptic could point out that this is exactly the kind of subgroup slicing that you are not supposed to do without pre-registering it, which I don’t think this team did. I agree with the skeptic. Vallejos et al: Another Argentine study. It’s big (250 people in each arm). It’s an RCT. It tries to define a primary outcome (“Primary outcome: the trial ended when the last patient who was included achieved the end of study visit”), but that’s not what “primary outcome” means, and they don’t offer an alternative. Other outcomes: no difference in PCR on days 3 or 12. Hospitalization is nonsignificantly better in the ivermectin group (14 vs. 21, p = 0.2), but death is nonsigificantly better in the placebo group (3 vs. 4, p = 0.7). This isn’t even the kind of nonsignificant that might contribute to an exciting meta-analysis later. This is just a pure null result. I cannot find any problem with this study, and neither can anyone else I checked. This is the biggest RCT we’ve seen so far, so we should take it seriously. TOGETHER Trial: Speaking of big RCTs… This one hasn’t been published yet. There’s a video of a talk about it, but I am not going to watch it, because it is a video, so I am getting information secondhand from eg here. Apparently, it compares 677 people (!) randomized to ivermectin to 678 people randomized to placebo. 86 ivermectin patients ended up in the hospital compared to 95 placebo patients, p-value not significant. This was a really big professional trial done by bigshot researchers from a major Canadian university, and the medical establishment is taking it much more seriously than any of these others. When it comes out, it will probably get published in a top journal. When discussing Lopez-Medina, I wrote: When people say things like “sure, a lot of small studies show good results for ivermectin, but the bigger and more professional trials don’t”, this is one of the two big professional trials they’re talking about. This is the other one. Not coincidentally, it’s also the other trial that ivmmeta.com has a warning letter underneath telling you to disregard. Their main concern is that instead of truly randomizing patients to ivermectin vs. placebo, they did a time-dependent randomization that meant during some weeks more patients were getting one or the other. This is a problem because the trial takes place in Brazil, where different variants were more common at different times. Here’s their image: On the one hand, I have immense contempt for ivmmeta for letting all those other awful studies pass and then pulling out all the stops to try to nitpick this one. I have no idea if their proposed randomization failure really happened. And no doubt the reason they’re even able to investigate this is that this study is really careful and transparent - most of them don’t tell you anything about their randomization method. I would be shocked if other studies don’t have all these problems and worse. On the other hand, the point isn’t to be fair, it’s to be right. And this is a potential confounder. Not a huge one. But a potential one. I guess all we can do is try to bound the damage. Even if the confounding is 100% real and bad, there’s no way to make this study consistent with the crazy super-pro-ivermectin results of studies like Espitia-Hernandez and Aref. And even if we deny any confounding, we see the same slight pro-ivermectin trend - 86 hospitalizations vs. 95 - that we’ve seen in so many other studies. Nothing is going to make me believe that this isn’t in the top 33% of studies we’ve been looking at, so let’s add it as grist for the meta-analysis (though maybe not quite as much grist as its vast size indicates) and move on, angrily. Buonfrate et al: An Italian RCT. Patients were randomized into low-dose ivermectin (32), placebo (29), or high-dose ivermectin (32). Primary outcome was viral load on day 7. There was no significant difference (average of 2 in ivermectin groups, 2.2 in placebo group). They admit that they failed to reach the planned sample size, but did a calculation to show that even if they had, the trial could not have returned a positive result. Clinically, an average of 2 patients were hospitalized in each of the ivermectin arms, compared to 0 in the placebo arm - which bucks our previously-very-constant pro-ivermectin trend. Mayer et al: Not an RCT. Patients in an Argentine province were offered the opportunity to try ivermectin; 3266 said yes and become the experimental group, 17966 said no and became the control group. There were many obvious differences between the groups, but they all seemed to handicap ivermectin. There was a nonsignificant trend toward less hospitalization and significantly less mortality (1.5% vs. 2.1%, p = 0.03). While looking into this study, I learned the term “immortal time bias”. This means a period in between selection for the study and the beginning of study recording where patient outcomes are not counted. I think the problem here is that if you signed up for the system on Day X, and if you got sick before they could give you ivermectin, you were in the control group. See this Twitter thread, I have not confirmed everything he says. This only hardens my resolve to stay away from non-RCTs. Borody et al: Our last paper! …is it a paper? I can’t find it published anywhere. It mostly seems to be on news sites. Doesn’t look peer-reviewed. And it starts with “Note that views expressed in this opinion article are the writer’s personal views”. Whatever. 600 Australians were treated with ivermectin, doxycycline, and zinc. The article compares this to an “equivalent control group” made of “contemporary infected subjects in Australia obtained from published Covid Tracking Data”; this is not how you control group, @#!% you. Then it gets excited about the fact that most patients had better symptoms at the end of the ten-day study period than the beginning (untreated COVID resolves in about ten days). Why are these people wasting my time with this? Let’s move on. The Analysis If we remove all fraudulent and methodologically unsound studies from the table above, we end up with this: Gideon Meyerowitz-Katz, who investigated many of the studies above for fraud, tried a similar exercise. I learned about his halfway through, couldn’t help seeing it briefly, but tried to avoid remembering it or using it when generating mine (also, I did take the result of his fraud investigations into account), so they should be considered not quite independent efforts. His looks like this: He nixed Chowdhury, Babaloba, Ghauri, Faisal, and Aref, but kept Szenta Fonseca, Biber (?), and Mayer. There was correlation of 0.45, which I guess is okay. I asked him about his decision-making, and he listed a combination of serious statistical errors and small red flags adding up. I was pretty uncomfortable with most of these studies myself, so I will err on the side of severity, and remove all studies that either I or Meyerowitz-Katz disliked. We end up with the following short list: We’ve gone from 29 studies to 11, getting rid of 18 along the way. For the record, we eliminated 2/19 for fraud, 1/19 for severe preregistration violations, 10 for methodological problems, and 6 because Meyerowitz-Katz was suspicious of them. …but honestly this table still looks pretty good for ivermectin, doesn’t it? Still lots of big green boxes. Meyerowitz-Katz accuses ivmmeta of cherry-picking what statistic to use for their forest plot. That is, if a study measures ten outcomes, they sometimes take the most pro-ivermectin outcome. Ivmmeta.com counters that they used a consistent and reasonable (if complicated) process for choosing their outcome of focus, that being: If studies report multiple kinds of effects then the most serious outcome is used in calculations for that study. For example, if effects for mortality and cases are both reported, the effect for mortality is used, this may be different to the effect that a study focused on. If symptomatic results are reported at multiple times, we used the latest time, for example if mortality results are provided at 14 days and 28 days, the results at 28 days are used. Mortality alone is preferred over combined outcomes. Outcomes with zero events in both arms were not used (the next most serious outcome is used — no studies were excluded). For example, in low-risk populations with no mortality, a reduction in mortality with treatment is not possible, however a reduction in hospitalization, for example, is still valuable. Clinical outcome is considered more important than PCR testing status. When basically all patients recover in both treatment and control groups, preference for viral clearance and recovery is given to results mid-recovery where available (after most or all patients have recovered there is no room for an effective treatment to do better). If only individual symptom data is available, the most serious symptom has priority, for example difficulty breathing or low SpO2 is more important than cough. I’m having trouble judging this, partly because Meyerowitz-Katz says ivmmeta has corrected some earlier mistakes, and partly because there really is some reasonable debate over how to judge studies with lots of complicated endpoints. By this point I had completely forgotten what ivmmeta did, so I independently coded all 11 remaining studies following something in between my best understanding of their procedure and what I considered common sense. The only exception was that when the most severe outcome was measured in something other than patients (ie average number of virus copies per patient), I defaulted to one that was measured in patients instead, to keep everything with the same denominator. My results mostly matched ivmmeta’s, with one or two exceptions that I think are within the scope of argument or related to my minor deviations from their protocol. Placebo vs. ivermectin groups sometimes differed in size, which I’ve adjusted for and rounded off. Probably I’m forgetting some reason I can’t just do simple summary statistics to this, but whatever. It is p = 0.15, not significant. This is maybe unfair, because there aren’t a lot of deaths in the sample, so by focusing on death rather than more common outcomes we’re pointlessly throwing away sample size. What happens if I unprincipledly pick whatever I think the most reasonable outcome to use from each study is? I’ve chosen “most reasonable” as a balance between “is the most severe” and “has a lot of data points”: Now it’s p = 0.04, seemingly significant, but I had to make some unprincipled decisions to get there. I don’t think I specifically replaced negative findings with positive ones, but I can’t prove that even to myself, let alone to you. [UPDATE 5/31/22: A reader writes in to tell me that the t-test I used above is overly simplistic. A Dersimonian-Laird test is more appropriate for meta-analysis, and would have given 0.03 and 0.005 on the first and second analysis, where I got 0.15 and 0.04. This significantly strengthens the apparent benefit of ivermectin from ‘debatable’ to ‘clear’. I discuss some reasons below why I am not convinced by this apparent benefit.] (how come I’m finding a bunch of things on the edge of significance, but the original ivmmeta site found a lot of extremely significant things? Because they combined ratios, such that “one death in placebo, zero in ivermectin” looked like a nigh-infinite benefit for ivermectin, whereas I’m combining raw numbers. Possibly my way is statistically illegitimate for some reason, but I’m just trying to get a rough estimate of how convinced to be) So we are stuck somewhere between “nonsignificant trend in favor” and “maybe-significant trend in favor, after throwing out some best practices”. This is normally where I would compare my results to those of other meta-analyses made by real professionals. But when I look at them, they all include studies later found to be fake, like Elgazzar, and unsurprisingly come up with wildly positive conclusions. There are about six in this category. One of them later revised their results to exclude Elgazzar and still found strong efficacy for ivermectin, but they still included Niaee and some other dubious studies. The only meta-analysis that doesn’t make these mistakes is Popp (a Cochrane review), which is from before Elgazzar was found to be fraudulent, but coincidentally excludes it for other reasons. It also excludes a lot of good studies like Mahmud and Ravakirti because they give patients other things like HCQ and azithromycin - I chose to include them, because I don’t think they either work or have especially bad side effects, so they’re basically placebo - but Cochrane is always harsh like this. They end up with a point estimate where ivermectin cuts mortality by 40% - but say the confidence intervals are too wide to draw any conclusion. I think this basically agrees with my analyses above - the trends really are in ivermectin’s favor, but once you eliminate all the questionable studies there are too few studies left to have enough statistical power to reach significance. Except that everyone is still focusing on deaths and hospitalizations just because they’re flashy. Mahmud et al, which everyone agrees is a great study, found that ivermectin decreased days until clinical recovery, p = 0.003? So what do you do? This is one of the toughest questions in medicine. It comes up again and again. You have some drug. You read some studies. Again and again, more people are surviving (or avoiding complications) when they get the drug. It’s a pattern strong enough to common-sensically notice. But there isn’t an undeniable, unbreachable fortress of evidence. The drug is really safe and doesn’t have a lot of side effects. So do you give it to your patients? Do you take it yourself? Here this question is especially tough, because, uh, if you say anything in favor of ivermectin you will be cast out of civilization and thrown into the circle of social hell reserved for Klan members and 1/6 insurrectionists. All the health officials in the world will shout “horse dewormer!” at you and compare you to Josef Mengele. But good doctors aren’t supposed to care about such things. Your only goal is to save your patient. Nothing else matters. I am telling you that Mahmud et al is a good study and it got p = 0.003 in favor of ivermectin. You can take the blue pill, and stay a decent respectable member of society. Or you can take the horse dewormer pill, and see where you end up. In a second, I’ll tell you my answer. But you won’t always have me to answer questions like this, and it might be morally edifying to observe your thought process in situations like this. So take a second, and meet me on the other side of the next section heading. … … … … … The Synthesis Hopefully you learned something interesting about yourself there. But my answer is: worms! As several doctors and researchers have pointed out (h/t especially Avi Bitterman and David Boulware), the most impressive studies come from places that are teeming with worms. Mahmud from Bangladesh, Ravakirti from East India, Lopez-Medina from Colombia, etc. Here’s the prevalence of roundworm infections by country (source). But alongside roundworms, there are threadworms, hookworms, blood flukes, liver flukes, nematodes, trematodes, all sorts of worms. Add them all up and somewhere between half and a quarter of people in the developing world have at least one parasitic worm in their body. Being full of worms may impact your ability to fight coronavirus. Gluchowska et al write: Helminth [ie worm] infections are among the most common infectious diseases. Bradbury et al. highlight the possible negative interactions between helminth infection and COVID-19 severity in helminth-endemic regions and note that alterations in the gut microbiome associated with helminth infection appear to have systemic immunomodulatory effects. It has also been proposed that helminth co-infection may increase the morbidity and mortality of COVID-19, because the immune system cannot efficiently respond to the virus; in addition, vaccines will be less effective for these patients, but treatment and prevention of helminth infections might reduce the negative effect of COVID-19. During millennia of parasite-host coevolution helminths evolved mechanisms suppressing the host immune responses, which may mitigate vaccine efficacy and increase severity of other infectious diseases. Treatment of worm infections might reduce the negative effect of COVID-19! And ivermectin is a deworming drug! You can see where this is going… The most relevant species of worm here is the roundworm Strongyloides stercoralis. Among the commonest treatments for COVID-19 is corticosteroids, a type of immunosuppresant drug. The types of immune responses it suppresses do more harm than good in coronavirus, so turning them off limits collateral damage and makes patients better on net. But these are also the types of immune responses that control Strongyloides. If you turn them off even very briefly, the worms multiply out of control, you get what’s called “Strongyloides hyperinfection”, and pretty often you die. According to the WHO: The current COVID-19 pandemic serves to highlight the risk of using systemic corticosteroids and, to a lesser extent, other immunosuppressive therapy, in populations with significant risk of underlying strongyloidiasis. Cases of strongyloidiasis hyperinfection in the setting of corticosteroid use as COVID-19 therapy have been described and draw attention to the necessity of addressing the risk of iatrogenic strongyloidiasis hyperinfection syndrome in infected individuals prior to corticosteroid administration. Although this has gained importance in the midst of a pandemic where corticosteroids are one of few therapies shown to improve mortality, its relevance is much broader given that corticosteroids and other immunosuppressive therapies have become increasingly common in treatment of chronic diseases (e.g. asthma or certain rheumatologic conditions). So you need to “address the risk” of strongyloides infection during COVID treatment in roundworm-endemic areas. And how might you address this, WHO? Treatment of chronic strongyloidiasis with ivermectin 200 µg/kg per day orally x 1-2 days is considered safe with potential contraindications including possible Loa loa infection (endemic in West and Central Africa), pregnancy, and weight <15kg. Given ivermectin’s safety profile, the United States has utilized presumptive treatment with ivermectin for strongyloidiasis in refugees resettling from endemic areas, and both Canada and the European Centre for Disease Prevention and Control have issued guidance on presumptive treatment to avoid hyperinfection in at risk populations. Screening and treatment, or where not available, addition of ivermectin to mass drug administration programs should be studied and considered. This is serious and common enough that, if you’re not going to screen for it, it might be worth “add[ing] ivermectin to mass drug administration programs” in affected areas! Dr. Avi Bitterman carries the hypothesis to the finish line: First two images are with all relevant studies; second two are a sensitivity analysis that removes some of the most dubious. The good ivermectin trials in areas with low Strongyloides prevalence, like Vallejos in Argentina, are mostly negative. The good ivermectin trials in areas with high Strongyloides prevalence, like Mahmud in Bangladesh, are mostly positive. Worms can’t explain the viral positivity outcomes (ie PCR), but Dr. Bitterman suggests that once you remove low quality trials and worm-related results, the rest looks like simple publication bias: This is still just a possibility. Maybe I’m over-focusing too hard on a couple positive results and this will all turn out to be nothing. Or who knows, maybe ivermectin does work against COVID a little - although it would have to be very little, fading to not at all in temperate worm-free countries. But this theory feels right to me. It feels right to me because it’s the most troll-ish possible solution. Everybody was wrong! The people who called it a miracle drug against COVID were wrong. The people who dismissed all the studies because they F@#king Love Science were wrong. Ivmmeta.com was wrong. Gideon Meyerowitz-Katz was…well, he was right, actually, I got the worm-related meta-analysis graphic above from his Twitter timeline. Still, an excellent troll. Also, the best part is that I ignorantly asked, in my description of Mahmud et al above: And it was! It was a fluke! A literal, physical, fluke! For my whole life, God has been placing terrible puns in my path to irritate me, and this would be the worst one ever! So it has to be true! The Scientific Takeaway About ten years ago, when the replication crisis started, we learned a certain set of tools for examining studies. Check for selection bias. Distrust “adjusting for confounders”. Check for p-hacking and forking paths. Make teams preregister their analyses. Do forest plots to find publication bias. Stop accepting p-values of 0.049. Wait for replications. Trust reviews and meta-analyses, instead of individual small studies. These were good tools. Having them was infinitely better than not having them. But even in 2014, I was writing about how many bad studies seemed to slip through the cracks even when we pushed this toolbox to its limits. We needed new tools. I think the methods that Meyerowitz-Katz, Sheldrake, Heathers, Brown, Lawrence and others brought to the limelight this year are some of the new tools we were waiting for. Part of this new toolset is to check for fraud. About 10 - 15% of the seemingly-good studies on ivermectin ended up extremely suspicious for fraud. Elgazzar, Carvallo, Niaee, Cadegiani, Samaha. There are ways to check for this even when you don’t have the raw data. Like: The Carlisle-Stouffer-Fisher method: Check some large group of comparisons, usually the Table 1 of an RCT where they compare the demographic characteristics of the control and experimental groups, for reasonable p-values. Real data will have p-values all over the map; one in every ten comparisons will have a p-value of 0.1 or less. Fakers seem bad at this and usually give everything a nice safe p-value like 0.8 or 0.9.
Inline links: Ravakirti et al:, Bukhari et al:, Mohan et al:, Biber et al:, the preregistration, Elalfy et al:, https://substackcdn.com/image/fetch/$s_!B_IH!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F4d3559ee-a058-44cc-9b38-09b78a0f5035_1352x1070.png, https://substackcdn.com/image/fetch/$s_!9mI_!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2Fbffceed7-c84a-45c1-abfe-1fb2706dc383_483x674.png, Lopez-Medina et al:, Roy et al:, Chahla et al:, Mourya et al:, Loue et al:, Table 1, Merino et al:, never works, Faisal et al:, Aref et al:, https://substackcdn.com/image/fetch/$s_!-FoK!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2Ff6de79b6-091b-4c13-b7be-715c9bb194a7_986x810.jpeg, Krolewiecki et al:, Vallejos et al:, TOGETHER Trial:, here, https://substackcdn.com/image/fetch/$s_!7X0m!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F1f65fd44-58b9-4489-a934-02a5a7330499_706x768.png, Buonfrate et al:, Mayer et al:, immortal time bias, this Twitter thread, Borody et al:, https://substackcdn.com/image/fetch/$s_!Wpjs!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F2d8a451b-b1fc-44e5-ae67-b1506e491762_914x657.png, https://substackcdn.com/image/fetch/$s_!DOjA!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F17d5827a-38da-4a99-beb3-c3018df5c633_920x604.png, https://substackcdn.com/image/fetch/$s_!GX1n!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2Fc692fec8-a450-4579-b337-c72bec060970_912x298.png, https://substackcdn.com/image/fetch/$s_!YcH4!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2Ff36db98e-e653-44da-906c-20312b1689a3_468x205.png, https://substackcdn.com/image/fetch/$s_!jbcL!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2Fd189a844-daf2-4199-bb2e-830d4fc64415_468x206.png, later revised their results to exclude Elgazzar, Popp, https://substackcdn.com/image/fetch/$s_!2B6r!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F505c5ac4-3fe8-47a4-8505-dab80601b44d_416x198.png, Avi Bitterman, David Boulware, https://substackcdn.com/image/fetch/$s_!JWWh!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2Fac9e4f34-f9cc-40f2-9d83-da4e7178fad7_772x330.png, source, Gluchowska et al, the WHO, carries, https://substackcdn.com/image/fetch/$s_!xExE!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F5da21781-249c-4e59-b616-9f23d83cc044_2048x1184.jpeg, https://substackcdn.com/image/fetch/$s_!4SMr!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2Fdcd6e4b2-37f7-4602-93d5-2581c3b27a60_700x432.png, https://substackcdn.com/image/fetch/$s_!-6n2!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F7fd6e8f4-093e-4e02-bce7-363615146c9c_2228x1346.jpeg, https://substackcdn.com/image/fetch/$s_!CPZs!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2Fb0425847-198a-4bd3-a63b-149f15d147ba_700x432.png, https://substackcdn.com/image/fetch/$s_!H3rK!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F9972491b-25b0-4c06-8aca-86fce102ae63_666x147.png, even in 2014, The Carlisle-Stouffer-Fisher method
…looks very impressive, in terms of the experimental group doing better than the control, except that they don’t specify whether it was before the trial or after it, and at least one online commentator thinks it might have been before, in which case it’s only impressive how thoroughly they failed to randomize their groups. Overall I don’t feel bad throwing this study out. I hope it one day succeeds in returning to its home planet. Lopez-Medina et al: Colombian RCT. 200 patients took ivermectin, another 200 took placebo. They originally worried the placebo might taste different than real ivermectin, then solved this by replacing it with a different placebo, which is a pretty high level of conscientiousness. Primary outcome was originally percent of patients whose symptoms worsened by two points, as rated on a complicated symptom scale when a researcher asked them over the phone. Halfway through the study, they realized nobody was worsening that much, so they changed the primary outcome to time until symptoms got better, as measured by the scale. In the ivermectin group, symptoms improved that much after 10 days; in the placebo group, after 12, p = 0.53. By the end of the study, symptoms had improved in 82% of ivermectin users and 79% of controls, also insignificant. 4 patients in the ivermectin group needed to be hospitalized compared to 6 in the placebo group, again insignificant. This study is bigger than most of the other RCTs, and more polished in terms of how many spelling errors, photographs of computer screens, etc, it contains. It was published in JAMA, one of the most prestigious US medical journals, as opposed to the crappy nth-tier journals most of the others have been in. When people say things like “sure, a lot of small studies show good results for ivermectin, but the bigger and more professional trials don’t”, this is one of the two big professional trials they’re talking about. Ivermectin proponents make some good arguments against it. In order to get as big as it did, Lopez-Medina had to compromise on rigor. Its outcome is how people self-score their symptoms on a hokey scale in a phone interview, instead of viral load or PCR results or anything like that. Still, this is basically what we want, right? In the end, we want people to feel better and less sick, not to get good scores on PCR tests. Also, it changed its primary outcome halfway through; isn’t that bad? I think maybe not; the reason we want a preregistered primary outcome is so that you don’t change halfway through to whatever outcome shows the results you want. The researchers in this study did a good job explaining why they changed their outcome, the change makes sense, and their original outcome would also have shown ivermectin not working (albeit less accurately and effectively). I don’t know of any evidence that they knew (or suspected) final results when switching to this new outcome, and it seems like the most reasonable new outcome to switch to. Finally, their original placebo tasted different from ivermectin (though they switched halfway through). This is one of the few studies where I actually care about placebo, because people are self-rating their symptoms. But realistically most of these people don’t know what ivermectin is supposed to taste like. Also, they did a re-analysis and found there was no difference between the people who got the old placebo and the new one. I’m making a big deal of this because ivmmeta.com - the really impressive meta-analysis site I’ve been going off of - puts a special warning letter underneath their discussion of this study, urging us not to trust it. They don’t do this for any of the other ones we’ve addressed so far - not the one by the guy whose other studies were all frauds, not the one where 50% of 21 people had headaches, not the unrandomized one where the groups were completely different before the experiment started, not even the one by the guy accused of crimes against humanity. Only this one. This makes me a lot less charitable to ivmmeta than I would otherwise be; I think it’s hard to choose this particular warning letter strategy out of well-intentioned commitment to truth. They just really don’t like this big study that shows ivermectin doesn’t work. Also, the warning itself irritates me, and includes paragraphs like: RCTs have a fundamental bias against finding an effect for interventions that are widely available — patients that believe they need treatment are more likely to decline participation and take the intervention [Yeh], i.e., RCTs are more likely to enroll low-risk participants that do not need treatment to recover (this does not apply to the typical pharmaceutical trial of a new drug that is otherwise unavailable). This trial was run in a community where ivermectin was available OTC and very widely known and used. Nobody else worries about this, and there are a million biases that non-randomized studies have that would be super-relevant when discussing those, but somehow when they’re pro-ivermectin the site forgets to be this thorough. I think a better pro-ivermectin response to this study is to point out that all the trends support ivermectin. Symptoms took 10 days to resolve in the ivermectin group vs. 12 in placebo; 4 ivermectin patients were hospitalized vs. 6 placebo patients, etc. Just say that this was an unusually noisy trial because of the self-report methodology, and you’re confident that these small differences will add up to significance when you put them into a meta-analysis. Roy et al: We’re back in East India, and back to non-randomized trials. 56 patients were retrospectively examined; some had been given ivermectin + doxycycline, others hydroxychloroquine, other azithromycin, and others symptomatic treatment only. We don’t get any meaningful information about how this worked, but we are told that they did not differ in “clinical well-being reporting onset timing”. Whatever. Chahla et al: The first of many Argentine trials. 110 patients received medium-dose ivermectin; 144 were kept as a control (no placebo). This was “cluster randomized”, which means they randomize different health centers to either give the experimental drug or not. This is worse than regular randomization, because there could be differences between these health centers (eg one might have better doctors who otherwise give better treatment, one might be in the poor part of town and have sicker patients, etc). They checked to see if there were any differences between the groups, and it sure looks like there were (the experimental group had twice as many obese people as the controls), but as per them, these differences were not statistically significant. Note that if this did make a difference, it would presumably make ivermectin look worse, not better. The primary outcome was given as “increase discharge from outpatient care with COVID-19 mild disease”. This favored the treatment; only 2/110 patients in the ivermectin group failed to be discharged, compared to 20 patients in the control group. But, uh, these were at different medical centers. Can’t different medical centers just have different discharge policies? One discharges you as soon as you seem to be getting better, the other waits to really make sure? This is an utterly crap endpoint to do a cluster randomized controlled trial on. If you’re going to do cRCT, which is never a great idea, you should be using some extremely objective endpoint that doctors and clinic administrators can’t possibly affect, like viral load according to some third-party laboratory, using the same third-party laboratory for both clinics. This is such a bad idea that I can’t help worrying I’m missing or misunderstanding something. If not, this is dumb and bad and should be ignored. Mourya et al: We’re back in India. This is a nonrandomized study comparing 50 patients given ivermectin to 50 patients given hydroxychloroquine. No primary outcome was named, but they focus on PCR negativity. Only 6% of patients in the hydroxychloroquine group were negative, compared to 90% of patients in the ivermectin group! On what day did they do the test? Uh, kind of random, and they admit that “in [the hydroxychloroquine group], mean time difference from the date of initiation of treatment and second test was significantly longer (7.24±2.75 days) as compared to 5.22±1.21 days in [the ivermectin group] (p=0.021).” Since they assessed these groups at different times, we shouldn’t draw any conclusions from them getting different results. Except that as far as I can tell this should handicap ivermectin, making it especially impressive that it did better. But also, the ivermectin group was made mostly of people who had been asymptomatic at the beginning (70%), and the hydroxychloroquine group had almost no asymptomatic cases (8%) . They were giving the ivermectin to healthy people and the hydroxychloroquine to sick people! They admit deep in the discussion that this “may be a confounding factor”. So basically they got totally different groups of people, tested them at totally different times, and the two sets of test results differed. So what? So this is why normal people do RCTs instead of whatever the heck this is, that’s what. Loue et al: …this one isn’t going to be an RCT either. Loue tells a story about a cluster of COVID cases at the French nursing home where he works. He asked people if they wanted to try ivermectin; 10 did and 15 didn’t. 1 ivermectin patient died, compared to 5 non-ivermectin patients. The non-ivermectin group looked a bit sicker than the ivermectin group in the inevitable Table 1, though it’s hard to tell. One interesting possible confounder (not mentioned, but I’m imagining it) is that demented patients probably couldn’t consent to ivermectin and ended up in the control group. This is another case of “I’m not going to trust anything that isn’t an RCT”. Merino et al: Another (sigh) non-RCT. Mexico City tried a public health program where if you called a hotline and said you had COVID, they sent you an emergency kit with various useful supplies. One of those supplies was ivermectin tablets. 18,074 people got the kit (and presumably some appreciable fraction took the ivermectin, though there’s no way to prove that). Their control group is people from before they started giving out the kits, people from after they stopped giving out the kits, and people who didn’t want the kits. There are differences in who got COVID early in the epidemic vs. later, and in people who did opt for medical kits vs. didn’t. To correct these, the researchers tried to adjust for confounders, something which - as I keep trying to hammer home again and again - never works. They found that using the kit led to a 75% or so reduction in hospitalization, though they were unable to separate out the ivermectin from the other things in the kit (paracetamol and aspirin), or from the placebo effect of having a kit and feeling like you had already gotten some treatment (if I understand right, the decision to go to the hospital was left entirely to the patient). I think this study is a moderate point in favor of giving people kits in order to prevent hospital overcrowding, but I’m not willing to accept that it tells us much about ivermectin in particular. Faisal et al: This one was published in The Professional Medical Journal (mispelled as “Profesional Medical Journal” in its URL), so you know it’s going to be good! It describes itself as “a cross-sectional study”, but later says it “randomized patients into two groups”, which would make it an RCT - I think they might just be using the term “cross-sectional” different from the standard American usage. A hospital in Pakistan got 50 patients on ivermectin + azithromycin, and another 50 on azithromycin alone. Primary outcome was not mentioned, and the data were presented confusingly, but a typical result is that only 4% of the ivermectin group had symptoms lasting more than 10 days, whereas 16% of the control group did, p < 0.01. They do a really weird thing where they compare how long it took symptoms to resolve between IVM and control groups within each bin. That is, if I’m understanding correctly, they ask “of the people who took between 3-5 days for symptoms to resolve, did they resolve faster for IVM or control?”. This is an utterly bizarre analysis to perform, although it doesn’t affect the fact that their other results still seem to favor ivermectin. Maybe I’m confused about what’s going on here. I’ve mostly been letting people off easy on no placebo, but I as far as I can tell (not very far) this paper seems to be going off whether patients reported continuing to have symptoms to the hospital doing the study, and I think that is potentially susceptible to placebo effects. Additionally, there’s no preregistration, and even though they talk a lot about doing PCR tests they don’t present the results. This is by no means the worst study here but I still think it’s pretty low quality and I don’t trust it. Aref et al: This one is published in the International Journal Of Nanomedicine, even though I’m pretty sure that isn’t a real thing. In this case the “nanomedicine” is a new nasal spray version of ivermectin which is so confusing I cannot for the life of me figure out what dose they are giving these patients. This Egyptian study gives 57 patients intranasal ivermectin plus hydroxychloroquine, azithromycin, oseltamavir, and some vitamins; another 57 patients get all that stuff except the ivermectin. Primary outcome is not stated, but they look at various symptoms, all of which look better in the ivermectin group: 95% of ivermectin patients got negative PCRs at some time point, compared to 75% of controls, p = 0.004. I am pretty suspicious of this study, not least because it comes from Egypt which has an awful reputation for fake studies, and it returns extreme results that I wouldn’t expect even if ivermectin was actually a wonder drug. But I cannot find any particular thing wrong with it, nor did anyone else I looked at, so I will grudgingly let it stand. Krolewiecki et al: Another Argentine study. This one is a real RCT. 30 patients received ivermectin, 15 were the control group (no placebo, again). Primary outcome was difference in viral load on day 5. The trend favored ivermectin but it was not statistically significant, although they were able to make it statistically significant if they looked at a subset of higher-IVM-plasma-concentration patients. They did not find any difference in clinical outcomes. A pro-ivermectin person could point out that in the subgroup with the highest ivermectin concentrations, the drug seemed to work. A skeptic could point out that this is exactly the kind of subgroup slicing that you are not supposed to do without pre-registering it, which I don’t think this team did. I agree with the skeptic. Vallejos et al: Another Argentine study. It’s big (250 people in each arm). It’s an RCT. It tries to define a primary outcome (“Primary outcome: the trial ended when the last patient who was included achieved the end of study visit”), but that’s not what “primary outcome” means, and they don’t offer an alternative. Other outcomes: no difference in PCR on days 3 or 12. Hospitalization is nonsignificantly better in the ivermectin group (14 vs. 21, p = 0.2), but death is nonsigificantly better in the placebo group (3 vs. 4, p = 0.7). This isn’t even the kind of nonsignificant that might contribute to an exciting meta-analysis later. This is just a pure null result. I cannot find any problem with this study, and neither can anyone else I checked. This is the biggest RCT we’ve seen so far, so we should take it seriously. TOGETHER Trial: Speaking of big RCTs… This one hasn’t been published yet. There’s a video of a talk about it, but I am not going to watch it, because it is a video, so I am getting information secondhand from eg here. Apparently, it compares 677 people (!) randomized to ivermectin to 678 people randomized to placebo. 86 ivermectin patients ended up in the hospital compared to 95 placebo patients, p-value not significant. This was a really big professional trial done by bigshot researchers from a major Canadian university, and the medical establishment is taking it much more seriously than any of these others. When it comes out, it will probably get published in a top journal. When discussing Lopez-Medina, I wrote: When people say things like “sure, a lot of small studies show good results for ivermectin, but the bigger and more professional trials don’t”, this is one of the two big professional trials they’re talking about. This is the other one. Not coincidentally, it’s also the other trial that ivmmeta.com has a warning letter underneath telling you to disregard. Their main concern is that instead of truly randomizing patients to ivermectin vs. placebo, they did a time-dependent randomization that meant during some weeks more patients were getting one or the other. This is a problem because the trial takes place in Brazil, where different variants were more common at different times. Here’s their image: On the one hand, I have immense contempt for ivmmeta for letting all those other awful studies pass and then pulling out all the stops to try to nitpick this one. I have no idea if their proposed randomization failure really happened. And no doubt the reason they’re even able to investigate this is that this study is really careful and transparent - most of them don’t tell you anything about their randomization method. I would be shocked if other studies don’t have all these problems and worse. On the other hand, the point isn’t to be fair, it’s to be right. And this is a potential confounder. Not a huge one. But a potential one. I guess all we can do is try to bound the damage. Even if the confounding is 100% real and bad, there’s no way to make this study consistent with the crazy super-pro-ivermectin results of studies like Espitia-Hernandez and Aref. And even if we deny any confounding, we see the same slight pro-ivermectin trend - 86 hospitalizations vs. 95 - that we’ve seen in so many other studies. Nothing is going to make me believe that this isn’t in the top 33% of studies we’ve been looking at, so let’s add it as grist for the meta-analysis (though maybe not quite as much grist as its vast size indicates) and move on, angrily. Buonfrate et al: An Italian RCT. Patients were randomized into low-dose ivermectin (32), placebo (29), or high-dose ivermectin (32). Primary outcome was viral load on day 7. There was no significant difference (average of 2 in ivermectin groups, 2.2 in placebo group). They admit that they failed to reach the planned sample size, but did a calculation to show that even if they had, the trial could not have returned a positive result. Clinically, an average of 2 patients were hospitalized in each of the ivermectin arms, compared to 0 in the placebo arm - which bucks our previously-very-constant pro-ivermectin trend. Mayer et al: Not an RCT. Patients in an Argentine province were offered the opportunity to try ivermectin; 3266 said yes and become the experimental group, 17966 said no and became the control group. There were many obvious differences between the groups, but they all seemed to handicap ivermectin. There was a nonsignificant trend toward less hospitalization and significantly less mortality (1.5% vs. 2.1%, p = 0.03). While looking into this study, I learned the term “immortal time bias”. This means a period in between selection for the study and the beginning of study recording where patient outcomes are not counted. I think the problem here is that if you signed up for the system on Day X, and if you got sick before they could give you ivermectin, you were in the control group. See this Twitter thread, I have not confirmed everything he says. This only hardens my resolve to stay away from non-RCTs. Borody et al: Our last paper! …is it a paper? I can’t find it published anywhere. It mostly seems to be on news sites. Doesn’t look peer-reviewed. And it starts with “Note that views expressed in this opinion article are the writer’s personal views”. Whatever. 600 Australians were treated with ivermectin, doxycycline, and zinc. The article compares this to an “equivalent control group” made of “contemporary infected subjects in Australia obtained from published Covid Tracking Data”; this is not how you control group, @#!% you. Then it gets excited about the fact that most patients had better symptoms at the end of the ten-day study period than the beginning (untreated COVID resolves in about ten days). Why are these people wasting my time with this? Let’s move on. The Analysis If we remove all fraudulent and methodologically unsound studies from the table above, we end up with this: Gideon Meyerowitz-Katz, who investigated many of the studies above for fraud, tried a similar exercise. I learned about his halfway through, couldn’t help seeing it briefly, but tried to avoid remembering it or using it when generating mine (also, I did take the result of his fraud investigations into account), so they should be considered not quite independent efforts. His looks like this: He nixed Chowdhury, Babaloba, Ghauri, Faisal, and Aref, but kept Szenta Fonseca, Biber (?), and Mayer. There was correlation of 0.45, which I guess is okay. I asked him about his decision-making, and he listed a combination of serious statistical errors and small red flags adding up. I was pretty uncomfortable with most of these studies myself, so I will err on the side of severity, and remove all studies that either I or Meyerowitz-Katz disliked. We end up with the following short list: We’ve gone from 29 studies to 11, getting rid of 18 along the way. For the record, we eliminated 2/19 for fraud, 1/19 for severe preregistration violations, 10 for methodological problems, and 6 because Meyerowitz-Katz was suspicious of them. …but honestly this table still looks pretty good for ivermectin, doesn’t it? Still lots of big green boxes. Meyerowitz-Katz accuses ivmmeta of cherry-picking what statistic to use for their forest plot. That is, if a study measures ten outcomes, they sometimes take the most pro-ivermectin outcome. Ivmmeta.com counters that they used a consistent and reasonable (if complicated) process for choosing their outcome of focus, that being: If studies report multiple kinds of effects then the most serious outcome is used in calculations for that study. For example, if effects for mortality and cases are both reported, the effect for mortality is used, this may be different to the effect that a study focused on. If symptomatic results are reported at multiple times, we used the latest time, for example if mortality results are provided at 14 days and 28 days, the results at 28 days are used. Mortality alone is preferred over combined outcomes. Outcomes with zero events in both arms were not used (the next most serious outcome is used — no studies were excluded). For example, in low-risk populations with no mortality, a reduction in mortality with treatment is not possible, however a reduction in hospitalization, for example, is still valuable. Clinical outcome is considered more important than PCR testing status. When basically all patients recover in both treatment and control groups, preference for viral clearance and recovery is given to results mid-recovery where available (after most or all patients have recovered there is no room for an effective treatment to do better). If only individual symptom data is available, the most serious symptom has priority, for example difficulty breathing or low SpO2 is more important than cough. I’m having trouble judging this, partly because Meyerowitz-Katz says ivmmeta has corrected some earlier mistakes, and partly because there really is some reasonable debate over how to judge studies with lots of complicated endpoints. By this point I had completely forgotten what ivmmeta did, so I independently coded all 11 remaining studies following something in between my best understanding of their procedure and what I considered common sense. The only exception was that when the most severe outcome was measured in something other than patients (ie average number of virus copies per patient), I defaulted to one that was measured in patients instead, to keep everything with the same denominator. My results mostly matched ivmmeta’s, with one or two exceptions that I think are within the scope of argument or related to my minor deviations from their protocol. Placebo vs. ivermectin groups sometimes differed in size, which I’ve adjusted for and rounded off. Probably I’m forgetting some reason I can’t just do simple summary statistics to this, but whatever. It is p = 0.15, not significant. This is maybe unfair, because there aren’t a lot of deaths in the sample, so by focusing on death rather than more common outcomes we’re pointlessly throwing away sample size. What happens if I unprincipledly pick whatever I think the most reasonable outcome to use from each study is? I’ve chosen “most reasonable” as a balance between “is the most severe” and “has a lot of data points”: Now it’s p = 0.04, seemingly significant, but I had to make some unprincipled decisions to get there. I don’t think I specifically replaced negative findings with positive ones, but I can’t prove that even to myself, let alone to you. [UPDATE 5/31/22: A reader writes in to tell me that the t-test I used above is overly simplistic. A Dersimonian-Laird test is more appropriate for meta-analysis, and would have given 0.03 and 0.005 on the first and second analysis, where I got 0.15 and 0.04. This significantly strengthens the apparent benefit of ivermectin from ‘debatable’ to ‘clear’. I discuss some reasons below why I am not convinced by this apparent benefit.] (how come I’m finding a bunch of things on the edge of significance, but the original ivmmeta site found a lot of extremely significant things? Because they combined ratios, such that “one death in placebo, zero in ivermectin” looked like a nigh-infinite benefit for ivermectin, whereas I’m combining raw numbers. Possibly my way is statistically illegitimate for some reason, but I’m just trying to get a rough estimate of how convinced to be) So we are stuck somewhere between “nonsignificant trend in favor” and “maybe-significant trend in favor, after throwing out some best practices”. This is normally where I would compare my results to those of other meta-analyses made by real professionals. But when I look at them, they all include studies later found to be fake, like Elgazzar, and unsurprisingly come up with wildly positive conclusions. There are about six in this category. One of them later revised their results to exclude Elgazzar and still found strong efficacy for ivermectin, but they still included Niaee and some other dubious studies. The only meta-analysis that doesn’t make these mistakes is Popp (a Cochrane review), which is from before Elgazzar was found to be fraudulent, but coincidentally excludes it for other reasons. It also excludes a lot of good studies like Mahmud and Ravakirti because they give patients other things like HCQ and azithromycin - I chose to include them, because I don’t think they either work or have especially bad side effects, so they’re basically placebo - but Cochrane is always harsh like this. They end up with a point estimate where ivermectin cuts mortality by 40% - but say the confidence intervals are too wide to draw any conclusion. I think this basically agrees with my analyses above - the trends really are in ivermectin’s favor, but once you eliminate all the questionable studies there are too few studies left to have enough statistical power to reach significance. Except that everyone is still focusing on deaths and hospitalizations just because they’re flashy. Mahmud et al, which everyone agrees is a great study, found that ivermectin decreased days until clinical recovery, p = 0.003? So what do you do? This is one of the toughest questions in medicine. It comes up again and again. You have some drug. You read some studies. Again and again, more people are surviving (or avoiding complications) when they get the drug. It’s a pattern strong enough to common-sensically notice. But there isn’t an undeniable, unbreachable fortress of evidence. The drug is really safe and doesn’t have a lot of side effects. So do you give it to your patients? Do you take it yourself? Here this question is especially tough, because, uh, if you say anything in favor of ivermectin you will be cast out of civilization and thrown into the circle of social hell reserved for Klan members and 1/6 insurrectionists. All the health officials in the world will shout “horse dewormer!” at you and compare you to Josef Mengele. But good doctors aren’t supposed to care about such things. Your only goal is to save your patient. Nothing else matters. I am telling you that Mahmud et al is a good study and it got p = 0.003 in favor of ivermectin. You can take the blue pill, and stay a decent respectable member of society. Or you can take the horse dewormer pill, and see where you end up. In a second, I’ll tell you my answer. But you won’t always have me to answer questions like this, and it might be morally edifying to observe your thought process in situations like this. So take a second, and meet me on the other side of the next section heading. … … … … … The Synthesis Hopefully you learned something interesting about yourself there. But my answer is: worms! As several doctors and researchers have pointed out (h/t especially Avi Bitterman and David Boulware), the most impressive studies come from places that are teeming with worms. Mahmud from Bangladesh, Ravakirti from East India, Lopez-Medina from Colombia, etc. Here’s the prevalence of roundworm infections by country (source). But alongside roundworms, there are threadworms, hookworms, blood flukes, liver flukes, nematodes, trematodes, all sorts of worms. Add them all up and somewhere between half and a quarter of people in the developing world have at least one parasitic worm in their body. Being full of worms may impact your ability to fight coronavirus. Gluchowska et al write: Helminth [ie worm] infections are among the most common infectious diseases. Bradbury et al. highlight the possible negative interactions between helminth infection and COVID-19 severity in helminth-endemic regions and note that alterations in the gut microbiome associated with helminth infection appear to have systemic immunomodulatory effects. It has also been proposed that helminth co-infection may increase the morbidity and mortality of COVID-19, because the immune system cannot efficiently respond to the virus; in addition, vaccines will be less effective for these patients, but treatment and prevention of helminth infections might reduce the negative effect of COVID-19. During millennia of parasite-host coevolution helminths evolved mechanisms suppressing the host immune responses, which may mitigate vaccine efficacy and increase severity of other infectious diseases. Treatment of worm infections might reduce the negative effect of COVID-19! And ivermectin is a deworming drug! You can see where this is going… The most relevant species of worm here is the roundworm Strongyloides stercoralis. Among the commonest treatments for COVID-19 is corticosteroids, a type of immunosuppresant drug. The types of immune responses it suppresses do more harm than good in coronavirus, so turning them off limits collateral damage and makes patients better on net. But these are also the types of immune responses that control Strongyloides. If you turn them off even very briefly, the worms multiply out of control, you get what’s called “Strongyloides hyperinfection”, and pretty often you die. According to the WHO: The current COVID-19 pandemic serves to highlight the risk of using systemic corticosteroids and, to a lesser extent, other immunosuppressive therapy, in populations with significant risk of underlying strongyloidiasis. Cases of strongyloidiasis hyperinfection in the setting of corticosteroid use as COVID-19 therapy have been described and draw attention to the necessity of addressing the risk of iatrogenic strongyloidiasis hyperinfection syndrome in infected individuals prior to corticosteroid administration. Although this has gained importance in the midst of a pandemic where corticosteroids are one of few therapies shown to improve mortality, its relevance is much broader given that corticosteroids and other immunosuppressive therapies have become increasingly common in treatment of chronic diseases (e.g. asthma or certain rheumatologic conditions). So you need to “address the risk” of strongyloides infection during COVID treatment in roundworm-endemic areas. And how might you address this, WHO? Treatment of chronic strongyloidiasis with ivermectin 200 µg/kg per day orally x 1-2 days is considered safe with potential contraindications including possible Loa loa infection (endemic in West and Central Africa), pregnancy, and weight <15kg. Given ivermectin’s safety profile, the United States has utilized presumptive treatment with ivermectin for strongyloidiasis in refugees resettling from endemic areas, and both Canada and the European Centre for Disease Prevention and Control have issued guidance on presumptive treatment to avoid hyperinfection in at risk populations. Screening and treatment, or where not available, addition of ivermectin to mass drug administration programs should be studied and considered. This is serious and common enough that, if you’re not going to screen for it, it might be worth “add[ing] ivermectin to mass drug administration programs” in affected areas! Dr. Avi Bitterman carries the hypothesis to the finish line: First two images are with all relevant studies; second two are a sensitivity analysis that removes some of the most dubious. The good ivermectin trials in areas with low Strongyloides prevalence, like Vallejos in Argentina, are mostly negative. The good ivermectin trials in areas with high Strongyloides prevalence, like Mahmud in Bangladesh, are mostly positive. Worms can’t explain the viral positivity outcomes (ie PCR), but Dr. Bitterman suggests that once you remove low quality trials and worm-related results, the rest looks like simple publication bias: This is still just a possibility. Maybe I’m over-focusing too hard on a couple positive results and this will all turn out to be nothing. Or who knows, maybe ivermectin does work against COVID a little - although it would have to be very little, fading to not at all in temperate worm-free countries. But this theory feels right to me. It feels right to me because it’s the most troll-ish possible solution. Everybody was wrong! The people who called it a miracle drug against COVID were wrong. The people who dismissed all the studies because they F@#king Love Science were wrong. Ivmmeta.com was wrong. Gideon Meyerowitz-Katz was…well, he was right, actually, I got the worm-related meta-analysis graphic above from his Twitter timeline. Still, an excellent troll. Also, the best part is that I ignorantly asked, in my description of Mahmud et al above: And it was! It was a fluke! A literal, physical, fluke! For my whole life, God has been placing terrible puns in my path to irritate me, and this would be the worst one ever! So it has to be true! The Scientific Takeaway About ten years ago, when the replication crisis started, we learned a certain set of tools for examining studies. Check for selection bias. Distrust “adjusting for confounders”. Check for p-hacking and forking paths. Make teams preregister their analyses. Do forest plots to find publication bias. Stop accepting p-values of 0.049. Wait for replications. Trust reviews and meta-analyses, instead of individual small studies. These were good tools. Having them was infinitely better than not having them. But even in 2014, I was writing about how many bad studies seemed to slip through the cracks even when we pushed this toolbox to its limits. We needed new tools. I think the methods that Meyerowitz-Katz, Sheldrake, Heathers, Brown, Lawrence and others brought to the limelight this year are some of the new tools we were waiting for. Part of this new toolset is to check for fraud. About 10 - 15% of the seemingly-good studies on ivermectin ended up extremely suspicious for fraud. Elgazzar, Carvallo, Niaee, Cadegiani, Samaha. There are ways to check for this even when you don’t have the raw data. Like: The Carlisle-Stouffer-Fisher method: Check some large group of comparisons, usually the Table 1 of an RCT where they compare the demographic characteristics of the control and experimental groups, for reasonable p-values. Real data will have p-values all over the map; one in every ten comparisons will have a p-value of 0.1 or less. Fakers seem bad at this and usually give everything a nice safe p-value like 0.8 or 0.9.
Inline links: Lopez-Medina et al:, Roy et al:, Chahla et al:, Mourya et al:, Loue et al:, Table 1, Merino et al:, never works, Faisal et al:, Aref et al:, https://substackcdn.com/image/fetch/$s_!-FoK!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2Ff6de79b6-091b-4c13-b7be-715c9bb194a7_986x810.jpeg, Krolewiecki et al:, Vallejos et al:, TOGETHER Trial:, here, https://substackcdn.com/image/fetch/$s_!7X0m!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F1f65fd44-58b9-4489-a934-02a5a7330499_706x768.png, Buonfrate et al:, Mayer et al:, immortal time bias, this Twitter thread, Borody et al:, https://substackcdn.com/image/fetch/$s_!Wpjs!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F2d8a451b-b1fc-44e5-ae67-b1506e491762_914x657.png, https://substackcdn.com/image/fetch/$s_!DOjA!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F17d5827a-38da-4a99-beb3-c3018df5c633_920x604.png, https://substackcdn.com/image/fetch/$s_!GX1n!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2Fc692fec8-a450-4579-b337-c72bec060970_912x298.png, https://substackcdn.com/image/fetch/$s_!YcH4!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2Ff36db98e-e653-44da-906c-20312b1689a3_468x205.png, https://substackcdn.com/image/fetch/$s_!jbcL!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2Fd189a844-daf2-4199-bb2e-830d4fc64415_468x206.png, later revised their results to exclude Elgazzar, Popp, https://substackcdn.com/image/fetch/$s_!2B6r!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F505c5ac4-3fe8-47a4-8505-dab80601b44d_416x198.png, Avi Bitterman, David Boulware, https://substackcdn.com/image/fetch/$s_!JWWh!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2Fac9e4f34-f9cc-40f2-9d83-da4e7178fad7_772x330.png, source, Gluchowska et al, the WHO, carries, https://substackcdn.com/image/fetch/$s_!xExE!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F5da21781-249c-4e59-b616-9f23d83cc044_2048x1184.jpeg, https://substackcdn.com/image/fetch/$s_!4SMr!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2Fdcd6e4b2-37f7-4602-93d5-2581c3b27a60_700x432.png, https://substackcdn.com/image/fetch/$s_!-6n2!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F7fd6e8f4-093e-4e02-bce7-363615146c9c_2228x1346.jpeg, https://substackcdn.com/image/fetch/$s_!CPZs!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2Fb0425847-198a-4bd3-a63b-149f15d147ba_700x432.png, https://substackcdn.com/image/fetch/$s_!H3rK!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F9972491b-25b0-4c06-8aca-86fce102ae63_666x147.png, even in 2014, The Carlisle-Stouffer-Fisher method
Obscure Pregnancy Interventions: Much More Than You Wanted To Know
April 13, 2022 · Original source
Doctors have been gradually chipping away at pregnant women’s ability to use pain medication. First it was “don’t use opioids, your baby could have birth defects”. Then it was “and don’t use ibuprofen, your baby could have kidney problems”. Then it was “and don’t use too much aspirin either, your baby could get cardiovascular problems”. That left Tylenol (aka Panadol, paracetamol, acetaminophen, etc) as the only pregnancy-safe pain reliever. Well, bad news…
Other studies ask women how much Tylenol they took when they were pregnant, then try to correlate it with offspring outcomes. The Consensus Statement lists 29 of these studies, and says 26 / 29 found evidence of harm. A typical study is Chen 2018, where researchers identify 950 kids with ADHD and 3800 kids without, and compare (using health system records) how likely their mothers were to have used Tylenol (finding that the ADHD moms were about 25% more likely). Even more sophisticated is Ji 2020, which found that “[umbilical] cord biomarkers of fetal exposure to acetaminophen were associated with significantly increased risk of childhood ADHD and ASD in a dose-response fashion.”
Inline links: Chen 2018, Ji 2020
ADHD is very genetic, so we should be alert for possible confounders like “ADHD moms get more stressed, have more headaches, and so use more Tylenol, and then their kids inherit their ADHD”. But we have two signs that this isn’t what’s going on here. First, a (relatively weak) finding that mothers who took the alternate headache medication ibuprofen did not have kids with more ADHD. And second, two studies (1, 2) finding that taking Tylenol immediately after or immediately before pregnancy has no effect - if it was just a proxy for class or ADHD you’d expect the same correlation regardless of the woman’s pregnancy status. All of this makes the effect look real.
Inline links: finding, 1, 2
Pascalian medicine2 mentions across 2 issues

Pascalian medicine is a recurring concept in the Astral Codex Ten archive, appearing 2 times across 2 issues between November 24, 2021 and February 01, 2023. The archive places it in contexts such as "Does Pascalian medicine beat our current strategy"; "I try to respond in Pascalian Medicine". It most often appears alongside Alexandros Marinos, COVID, hydroxychloroquine.

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Pascalian medicine
Mention count
2
Issue count
2
First seen
November 24, 2021
Last seen
February 01, 2023
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Pascalian Medicine
November 24, 2021 · Original source
Even if Pascalian medicine is an individually reasonable choice, might it be bad at the level of society? No individual drug or supplement we’ve talked about so far costs very much money. But giving twenty inexpensive things to everyone with every disease quickly becomes expensive. On the other hand, the US medical system gave up on caring about costs long ago, and it’s not clear this would cost any more than eg Aduhelm or several other bad decisions we’ve already made.
Inline links: Aduhelm
Still, if this is true, you might conclude that it just means doctors shouldn’t universally recommend Pascalian medicine. It could still be rational to set up a course of it on your own.
There’s a potential compromise solution, where smart doctors come up with Pascalian medicine protocols for the few patients who would actually want them. But this would be a weird enough thing for a doctor to do that it would run into the “I wouldn’t trust any club that would accept me as a member” problem.
Response To Alexandros Contra Me On Ivermectin
February 01, 2023 · Original source
This isn’t how mainstream medicine thinks about this in any other context, and if true it’s much more interesting than a debate around one particular repurposed dewormer. I try to respond in Pascalian Medicine. But since then, there’s been more evidence that ivermectin at the doses used in COVID studies might be harmful. Both the I-TECH study and Dr. Bitterman’s analysis found more severe side effects in ivermectin groups compared to placebo. Not only does this challenge ivermectin in particular, but using it as a test case calls Omura’s Wager into question more generally.
Inline links: Pascalian Medicine, the I-TECH study, Dr. Bitterman’s analysis
PCPs2 mentions across 2 issues

PCPs is a recurring concept in the Astral Codex Ten archive, appearing 2 times across 2 issues between November 24, 2022 and April 03, 2023. The archive places it in contexts such as "Only 75% of Americans have PCPs at all"; "“PCPs in this country are used to being asked to sign and complete all kinds of nonsense forms”". It most often appears alongside Adderall, Canada, DEA.

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PCPs
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2
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2
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November 24, 2022
Last seen
April 03, 2023
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Semaglutidonomics
November 24, 2022 · Original source
Semaglutide is now as searched-for on Google as Prozac or Viagra. Even if this is a temporary Musk-related spike, even pre-Musk it was getting a little above half their level. But Google Trends doesn’t exactly track awareness; few people search for Prozac these days precisely because everyone already knows what it is. So all this tells us is that there’s a lot of buzz around semaglutide. Suppose for the sake of argument that 5% of obese people have heard of this drug. Step 2: Prescription Accessibility The FDA says Wegovy is indicated for obesity, defined as BMI ≥ 30, or for people with BMI ≥ 27 and certain medical conditions. Does that mean that if you have that BMI, your doctor will give you a prescription? I think most doctors will want patients to try diet and exercise first. My experience as a doctor is that most obese people have already considered diet and exercise. Sometimes if you have a very compelling reason and a very well-thought out plan you can get them to try again. But usually they are obese because diet and exercise are hard for them, or don’t work for them, or some other reason besides “they never thought of it”. Still, I hear lots of stories about patient-doctor fights here. I assume this will happen with Wegovy too. Every doctor will have their own threshold for what amount of “already tried diet and exercise” is enough to justify a Wegovy prescription, and sometimes patients won’t meet that threshold. The history of medicine includes the following story many times: there’s some condition that doctors recommend lifestyle changes for. Then an exciting new medication comes out that treats the condition effectively. Over a generation or so, doctors go from demanding the lifestyle change, to gesturing at the lifestyle change before prescribing the medication, to mostly just prescribing the medication. We saw this with cholesterol and statins, with hypertension and ACE inhibitors, with depression and SSRIs. You can form your own opinion on whether this is good or bad, but we’re probably in the very beginning of this process with obesity. Opinions will be all over the map for a while before the inevitable pharma company victory makes everyone agree that semaglutide is first-line therapy. …except that this time, Silicon Valley is short-circuiting the process with fly-by-night telemedicine companies that guarantee you’ll get the drugs you want. For example, NextMed charges $138/month ($99 first month only!) for a guaranteed GLP-1 agonist prescription, plus “support and messaging with expert doctors”. The DEA sometimes shuts these groups down when they start playing around with controlled substances (eg addictive drugs like Adderall), but Wegovy isn’t controlled, and the government probably doesn’t care that much here. These services guarantee that people with money will be able to circumvent conservative doctors and access a prescription. Only 75% of Americans have PCPs at all. If we assume half of them will eventually be able to get a Wegovy prescription from their doctor, that’s 37.5%. Step 3: Affordability Semaglutide costs $15,000/year. Well-off people like Elon Musk might be able to pay that out-of-pocket, but most people will probably need insurance coverage. Right now this is spotty. Medicare doesn’t cover obesity drugs. This isn’t a reaction to the threat of semaglutide-related cost explosions - they’re not that smart. I think Medicare laws were just written in the old days when people were less likely to think of obesity as a disease. Is it time for change? Some Congressmen have proposed a very noble-sounding law telling Medicare and Medicaid to start covering weight loss drugs. I‘m sure this is out of deep compassion for America’s obese population and not because it would make pharma companies one billion zillion dollars. One of the Congressmen even has the last name “Kind!” Some pharma lobbyist probably got a bonus for that one. Private insurers mostly have to cover whatever Medicare does, but they can choose whether or not to include extra non-Medicare-covered drugs. Some have chosen to cover semaglutide under some conditions. Others would prefer not to cover it, but can be scared into covering it by the magic words “medical necessity”. Overall I don’t understand the laws here beyond that maybe they’ll cover it and maybe they won’t. Here, too, it might be time for change. The New York Times is publishing articles trying to convince us that private insurances not covering semaglutide is an outrage. Here in the tiny gray text, I want to take a second to complain about this article. It notes that Wegovy (semaglutide for obesity) costs more per prescription than Ozempic (semaglutide for diabetes), and calls this “a gross inequity”, accusing Novo Nordisk of “charg[ing] people more for the same drug because of their obesity”. But the obesity prescription is higher dose than the diabetes prescription! Milligram per milligram, Wegovy costs *less* than Ozempic! A steelmanned version of the NYT might object - don’t most of the costs come from the intellectual property and not the manufacturing, so that dose shouldn’t matter? Yes, but if you made the obesity version cost too much less per milligram than the diabetes version, then diabetics would cheat the system by buying the obesity version and splitting it into smaller doses! Insurances that do cover it may require extra documentation that the patient has tried lots of diet and exercise, maybe including some official diet-and-exercise program like WeightWatchers. They might also want documentation that patients have tried cheaper earlier-generation weight loss drugs without success. Even when insurances do cover semaglutide, copays may be very high. I have a pretty minimal insurance and it looks like if I got semaglutide my copay would be about $500/month until I reach my out of pocket limit. Harsh. People with better insurances might get hit less hard, but I don’t think anyone will be picking this up for cheap. Let’s say only 5% of people who clear all previous hurdles can afford the drug. How Many People Get Semaglutide? 140 million obese Americans * 25% interested * 5% know of semaglutide’s existence * 37.5% can get prescriptions * 5% can afford it = 33,000, which is a pretty good match for the 50,000 estimated prescriptions. I didn’t even fudge the numbers to come out right, it just happened. The Coming Decade As a service to pharma investors, Morgan Stanley modeled the economic future of obesity medications over the next decade. Their headline result: semaglutide and various semaglutide-copycat-drugs will be a $30 billion market by 2030. That’s less than the $500 billion disaster I was afraid of! But still almost 10% of all US drug spending! Here are two core analyses from the report: The first analysis asks “what if doctors medicalized obesity as comprehensively as they’ve medicalized hypertension and high cholesterol?” That is: what if we put in a society-wide effort to get every obese person to a doctor, and after only a little diet and exercise, the doctor puts them on a medication? They find that the US obesity market would multiply by a factor of 25, to about $87 billion/year. The second analysis is a more realistic projection for the next decade. Two things stand out. First, the number of patients on Wegovy or related medications goes from an estimated 46,910 now (pretty close to my 50,000 estimate!) to 11.3 million in 2030. Second, the cost per prescription goes from $15,000/year to about $4,000 year. Let’s look at this second change in more detail. Right now semaglutide is literally in a class of its own for weight loss. But remember, it started as a GLP-1 agonist diabetes drug. And there are other GLP-1 agonists already in use for diabetes. Novo Nordisk’s competitor Eli Lilly owns a closely related molecule, tirzepatide (Mounjaro®). They’ve already done studies showing it also works very well for weight loss - if anything even better than semaglutide - and they’re expected to get FDA approval to market it as a weight loss medication next year. Although capitalism fans might expect the presence of two competing drugs to immediately drive down prices, this is mysteriously not how things work in health care and prices will probably stay the same in the short term. But several other companies are working on semaglutide-like drugs, some will be cheaper to produce than semaglutide, and Morgan Stanley expects that this stronger level of competition will eventually drive costs down to $350/month ($4,000/year) by 2030. “Mounjaro” sounds like the playful animal sidekick in a Disney movie. From a purely economic perspective, semaglutide costs the health system money (because it’s expensive) but also saves the health system money (because we don’t have to pay for obesity consequences like diabetes and heart attacks). Which effect wins out? According to the Institute for Clinical and Economic Review, benefits would outweigh costs if semaglutide cost less than about $8,000/year. Since it costs $15,000 year now, it’s not cost effective. But if Morgan Stanley’s model comes true and it costs $4,000/year in 2030, then it will be cost effective. So at some point, Medicare (and so insurance companies) may start covering it more out of self-interest. I can’t tell whether the model takes this into account or not. (there’s also a third-level effect where it costs the health system money again, because it prevents people from dying of obesity-related complications, and dead people stop needing expensive health care. I think health economists are supposed to ignore this level.) 11.3 million prescriptions at $4,000/year comes to $45 billion, but Morgan Stanley expects that not everyone will fill their prescriptions consistently or stay on the medication the same amount of time, leading to their $31 billion figure. Towards The Glorious Post-Obesity Transhuman Future The Morgan Stanley report shows that even the greediest pharma investors, openly plotting to medicalize obesity, can’t bring themselves to believe in more than 11 million US semaglutide patients by 2030. That’s less than 10% of the US obese population. Isn’t that kind of disappointing? We’ve got > 100 million people dealing with a condition that not only makes them unhealthy, but also causes them psychological distress, and makes lots of people low-grade disappointed in and repulsed by our society. And we’ve got an effective drug that treats the condition. And we’re going to use it on less than 10% of the people involved? In 2032, semaglutide goes off-patent. It will probably take a few years to sort out legal issues and ramp up generic production, but by the mid-2030s, its price will go way down. I don’t think there are technical barriers to getting it down as low as $10 - $100 per month. By then, maybe there will be even more exciting branded weight loss drugs for wealthy people to choose from. But at the very least, semaglutide itself should become much more widely available even to poor or uninsured patients. I’m not sure what will happen. Will there be an inflection point, where so many people use semaglutide that obesity becomes unusual again, and then the remaining obese people start using it just to fit in? Will obesity become an optional fashion statement, like shaving your head or getting a tattoo? Or will semaglutide end up disappointing us in some way, like so many promising drugs have before? I come at semaglutide from a transhumanist perspective. I want to hack genetics and biology until everyone is as tall as they want, as strong as they want, as smart as they want, and whatever gender they want. If you want wings, you should be able to have wings. And yes, part of this vision is everyone having the weight they want. I’m not sure this will happen, but for the first time I can see a clear path to how it might. Postscript 1: Should You Take Semaglutide? I can’t answer this, please ask your doctor. But I do want to add that there are potential side effects I haven’t mentioned in this post, including nausea, gastrointestinal problems, pancreatitis, and kidney problems. Semaglutide has been accused of slightly increasing risk of pancreatic and thyroid cancers. Studies have found trends in this direction, but these conditions are so rare that even over thousands of patients over many years, the increase hasn’t yet reached clear statistical significance. The current consensus position is that it may increase thyroid cancer by a tiny amount not relevant to most patients, and that it probably doesn’t increase pancreatic cancer. I think my father has looked over these data more and is less sure than other people about the lack of pancreatic cancer risk, but he can’t get the resources he needs to prove anything, and I can’t remember his exact argument. More broadly: like all medications, semaglutide has benefits and risks, and you shouldn’t blindly take it after reading one blog article. Postscript 2: Is There A Way To Cheat The System To Get Semaglutide For Lower Cost? Health care is much like airline tickets: everyone pays a different price for everything and there’s usually a secret way to get what you want for much less money. Is this true of semaglutide? Pharma company Novo Nordisk offers a Savings Card that they say brings the price down to as low as $25 per month. I’m a little suspicious of this - pharma company offers are rarely as good as they sound - but I don’t notice any obvious tricks in this one and it should probably be your first bet. This startup claims that they can get insured people semaglutide for a $25/month copay “after their deductible is met” by negotiating with the insurance company very effectively. I can’t imagine how that works or what they have to negotiate with, but they seem pretty convinced, so I would welcome more information. Otherwise, you don’t have many great options. Although there are two older forms of semaglutide not FDA-approved for weight loss - Ozempic and Rybelsus - these are both more expensive, milligram per milligram, than Wegovy itself. Canada is also of no help. The usual Canadian pharmacies don’t seem to carry Wegovy, and charge about the same amount for Ozempic as American pharmacies do. This article in Drug Discovery Trends says that compounding pharmacies have been selling semaglutide for $300/month, less than a quarter of the sticker price. This is a bit confusing: compounding pharmacies are small local operations permitted to dispense unusual medications by mixing existing ones together in nonstandard ways. They’re arguing that they can legally dispense the semaglutide because they’re mixing it with vitamins, which, fine, but how are they getting it in the first place? Everyone else seems as confused as I am: "Nobody knows how [compounding pharmacies are] getting it," said Karl Nadolsky, an endocrinologist at Spectrum Health. "Who's making it? [The pharma company that makes it] Novo [Nordisk]'s not giving it to them. They're the ones with the rights to the molecule, so how is anybody getting semaglutide?" Has nobody asked compounding pharmacists about this? Do they have a conspiracy of silence? Does the FDA sometimes send their goons in to extract the information, but the compounding pharmacists compound sleeping gas / smoke grenades and vanish into the night? Anyway, the usual authorities warn you not to take compounded semaglutide under any circumstances, but they’re the same people who tell you never to buy drugs from a Canadian pharmacy because they might be adulterated. You can decide how much you want to trust them. Postscript 3: What About Europe And The Rest Of The World? Countries that are not the US usually negotiate with pharmaceutical companies over price. Because of some combination of “negotiation works” and “they are free-riding off Americans’ hard work”, they usually get much lower prices. What does semaglutide cost elsewhere? This is hard to find out because government health agencies sometimes keep their prices secret, plus Wegovy mostly isn’t available in other countries yet. The only information I could find was from Britain, which is in the process of making Wegovy available to patients. It looks like NHS will “restrict the expensive drug’s availability to very obese people attending specialist weight-loss clinics”, but that it might be possible to get it from private clinics for £199/month = £2400/year. Wegovy has been approved in the EU but doesn’t seem to have made it there yet. I can’t find any information about any other country. Non-weight-loss-indicated versions of semaglutide are available in many countries, but I wouldn’t expect their health care systems to be flexible about redirecting it for weight. Canadian regulators have approved Wegovy, but it doesn’t seem to be available there yet. I haven’t seen any evidence that Ozempic costs less in Canada than it does in the US, and I’m not sure why. Maybe the pharma companies have figured out that anything that happens in Canada gets imported into the US, and they’re playing hardball this time. I don’t know whether Canadians will be able to get it for cheaper than Americans or not. Postscript 4: Predictions (all predictions are conditional on no singularity or global catastrophe) 10 million Americans on semaglutide (or yet-to-be-approved equally good or superior alternatives) by 2030: 75%
Inline links: NextMed, a very noble-sounding law, https://substackcdn.com/image/fetch/$s_!l_X7!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F1dbb9e98-6e07-4237-988e-3b7a61af3e5a_1381x834.png, is publishing articles, https://substackcdn.com/image/fetch/$s_!R-zS!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F0f24b293-27de-462a-84fd-bed2ba7cf07f_1723x831.png, modeled the economic future of obesity medications over the next decade, https://substackcdn.com/image/fetch/$s_!zSOS!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F0906b28a-1ad4-421d-a055-87ed95db59ce_918x261.png, https://substackcdn.com/image/fetch/$s_!QJj9!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2Fb966f730-6b24-48e1-98b1-e710cda9264c_903x656.png, this is mysteriously not how things work in health care, https://substackcdn.com/image/fetch/$s_!5poy!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2Fc201f05a-7d1f-4738-911f-11d0d051adf9_2880x1562.png, Institute for Clinical and Economic Review, don’t think there are technical barriers, offers a Savings Card, This startup, about the same amount for Ozempic, This article in Drug Discovery Trends, Everyone else seems as confused as I am, NHS will, private clinics
Highlights From The Comments On Telemedicine Regulations
April 03, 2023 · Original source
If for some reason that doesn’t work, go to a different psychiatrist and try again. You don’t have to tell them you already tried. Since everything about ADHD diagnosis and treatment is already security theater, it’s hard to say what pill mills are doing except kind of smirking under their breath while going through the rituals - as opposed to real doctors, who go through the rituals with sincere faith. Don’t get me wrong, I do think there’s a difference here. But the regulatory state isn’t set up to say “And you have to sincerely believe in the rituals or they don’t count”. So instead they punish unrelated groups, like telepsychiatrists. See also my old post Bureaucracy As Active Ingredient. The security theater doesn’t work because it’s effective. It works because it’s inconvenient enough to weed out the less motivated fakers, and some of the remaining fakers get cold feet about lying to a nice sincere psychiatrist who seems to be trying to help them. Pill mills remove the inconvenience, and seem to be nod-and-wink cooperating with liars, so the theater stops working. The only solution is to inject some inconvenience and shame back into the process somewhere, which the DEA has chosen to do by restricting telepsychiatry. They could accomplish the same goal by making you attend your appointments naked, but I guess clothing companies have better lobbyists than telepsychiatrists do. 4: Comments About Forcing Blind People To Fill Out Forms Before They Can Access Braille I analogized forcing patients to see an in-person doctor before they could access a teledoctor to forcing blind people to fill out forms before they could access Braille. Several blind people and their friends pitched in to say this was a real problem. For example, Mikolysz: Blind person here, this kind of thing is actually much more common than people imagine. Many government agencies (regardless of which particular government you mean) just assume that anybody who needs to fill a form can read and write print and/or lives with somebody who does. This is often a problem even when the form in question is specifically targeted at blind people. Non-governmental organizations, including those who specifically serve the blind, aren't much better at this either. This issue is slightly more pronounced in civil law countries, where what constitutes a legally-binding signature is clearly defined in law and you can't just Docusign your way out of the problem, but it exists everywhere, including the US. I literally had to file this kind of document today, while the main form could be filled electronically, I was required to attach a few extra documents, for GDPR and such, and those had to be printed, filled in by a sighted person, signed and scanned. The same problem exists with physical mail which you're required to read and respond to, but which is almost never available in an accessible form, a few exceptions like the American IRS notwithstanding. 5: Comments About My Caricature Of A Doctor Who Refuses To Prescribe Psych Drugs Because People Just Need Jesus Jon Cutchins writes: You don't want psychiatrists and liberals in general to be accused of an unreasoning hatred towards Christianity you should probably be more judicious in your use of anti-Christian tropes when describing everyone who is skeptical of mind-altering drugs. Mike writes: I’ve been a primary care nurse practitioner in the Bible Belt for 20yrs and not once have I even heard of a provider telling a patient they should substitute religion for psychiatric (or any) medication. It’s so easy for some people to throw around these tropes as if Christianity is some exotic, weird tribe with horrifying anthropological traits. On the other hand, fluxe writes: I am a young Christian--in my life, I have -been told by my PCP not to get an IUD because it carries "a significant risk of causing infertility or death" -had a pharmacist refuse to fill an old, male family friend's ulcer medication because it's also an abortifacient -been told by a therapist to discontinue the SSRI a different provider had prescribed and just trust in the man of the house the PCP wasn't even particularly Christian herself, but since all of her patients are she hadn't updated on IUDs since the scare back in the 70s. Our horrifying anthropological traits become everyone's problem--it might be worth listening to those who "throw around these tropes" so you can understand what they have to deal with Unfortunately I only mention this possibility because it’s happened to several of my patients. The best I can offer in terms of being unbiased and apolitical is to signal-boost posts like this one about overly woke therapists being another big problem. Alien on Earth writes: I generally like your writing and ideas, hell, I just re-uped for a year. However, in an otherwise near perfect post, you took a cheap shot at a steriotyped view of one religion thst is not popular amoungst coastal elites, that really detracts from your core point. "The worst-case is that you get one of those doctors who think that Psych Drugs Aren’t Real Because You Just Need Jesus, and then the patient has to keep looking until they find someone else." In my experience, it is the new age(y), non-religious, doctors who are least likely to like prescribing psyc. meds or who tend to give them at too low a dose or for too short a time. Certainly, I've found little correlation with their religion, if I even know it. The only correlation I've observed is that this perscription reluctance is, perhaps, slightly more common amongst middle career doctors. Perhaps it is more common in deep red areas, I don't know. However, even there, I would suggest, it is less due to religion, per se, than to "old fashion" "grit your teeth and bear it" thinking. I agree that there are many reasons people recommend against psychiatric drugs (a few are even good). Psychiatric drugs have lots of side effects and are clearly imperfect options, and I see people object to them more often when they think they have a perfect option as an alternative. Sometimes that option is Jesus. Other times it’s the trendy new somatic yoga reprocessing kundalini trauma dianetics therapy. Other times it’s LSD or ketamine or Dr. Bob’s 24-In-One Internet Nootropic. All of these work for some people, but not as much as the people pushing them think - which I guess is also true for psych drugs. I’m nervous about people who think they’ve found the answer and pressure people towards one alternative or another without presenting evidence. I’ve seen this happen enough in religious contexts that I think it was a fair thing to use as an example. 6: Comments About Which Part Of The Government Is Responsible For This Regulation ProfessorE writes: I’m not sure that what Scott wrote is even completely accurate. I have a relative who is an MD in this space, and it seems that the underlying problem is not the DEA but an actual law passed by Congress. Aren’t telemedicine regulations limited with respect to controlled substances by the Ryan Haight Act of 2008 U.S.C. § 829(e)… there may be interpretations of this act by the DEA and other agencies, but, where controlled substances are prescribed by means of the Internet, the general requirement is that the prescribing Practitioner must have conducted at least one in-person medical evaluation of the patient. It seems like a colossal overreach to ask an Executive Branch agency to overrule the plain text of the act. There are some exceptions, which Scott noted. A different way of looking at things was that the Executive Branch was highly responsive to the emergency situation of Covid. Now that it’s not an emergency, they are obligated to return to the legal framework that exists. Congress needs to change the law, not the DEA. The *data* from covid should be used as part of a cost-benefit analysis to determine whether it is reasonable to regulate telemedicine, and, if so, what regulations might address whatever problems arose. Followed by: Actually, Scott is even more off-base than I thought in my initial post. Apparently the DEA & DOJ are already proposing new changes to the 2008 Act (which seem like they violate the clear text of the act), but the act and the changes are summarized here: https://www.legitscript.com/2023/03/27/proposed-changes-ryan-haight/ Sounds like government is aware of the issue. See https://www.federalregister.gov/documents/2023/03/01/2023-04248/telemedicine-prescribing-of-controlled-substances-when-the-practitioner-and-the-patient-have-not-had For the actual changes that are being proposed. End of the day, this should be modified by Congress, not the agencies. Everyone should remember that the law was written in 2008. That’s 1 year after the very first iPhone and 2 years before the first iPad. Zoom didn’t exist (2011). None of the other technologies for video conferencing existed. Congress was attempting to fight opioid pill-mills. At the time of passage, I am willing to bet that ≈0% of patients were “Telehealth” using videoconferencing. More like phone calls and email a few times to get drugs. The law should have been amended, and it hasn’t been, but it is far from clear that it was a crazy law in the first place. I mostly accept this correction, although I’m still a bit confused - a lot of the analyses by lawyers I read said things like “Unquestionably, the DEA’s proposal is not what most industry stakeholders were anticipating. The initial reaction is the rules are more restrictive than necessary and impose concerning limitations and burdens on clinicians and the patients they treat”, and I’m confused why industry stakeholders weren’t anticipating it if the DEA had to do it in order to follow the law. And JR writes: Meanwhile, the DEA was instructed by law in -2008- to develop a special registration process for telemedicine to allow providers to prescribe controlled substances remotely. The DEA has simply failed to do so in that time, despite repeated Congressional demands to act. Don't worry, though - the DEA has said about this proposed rule that it feels this will be 'less burdensome' for providers than any kind of special registration, so it feels it has discharged its legal responsibility to create a special registration process. I am a psychiatrist having to deal with this idiocy with my patients too, and renting an office temporarily is not going to cut it. So I am going the letter route. I will probably a lose a reasonable chunk of patients I was prescribing controlled substances to. The only possible saving grace is that PCPs in this country are used to being asked to sign and complete all kinds of nonsense forms and documents so probably most of them will just do it with minimal fuss. I'm more concerned with the new requirement that all telemedicine scripts now have to be recorded by the prescriber with the date and time they were written, the PHYSICAL ADDRESS of the prescriber and patient at the time of the telehealth encounter, and have an explicit note on them that they are telemedicine prescriptions. I am less concerned about PCPs balking at writing an idiotic referral than I am skittish pharmacists refusing to fill scripts that they might interpret as being labeled equivalently to FAKE SCRIPT FOR DRUGSEEKERS Based on that comment and this, my best guess about what’s happening is: Congress passed restrictions on telemedicine in 2001, and asked the DEA to come up with a way that trusted providers could avoid those restrictions. Now that there is videoconferencing, etc, most people now believe those restrictions were too severe.
Inline links: Bureaucracy As Active Ingredient, Mikolysz, writes, writes, writes, to signal-boost posts like this one about overly woke therapists being another big problem, writes, writes, Followed by, https://www.legitscript.com/2023/03/27/proposed-changes-ryan-haight/, https://www.federalregister.gov/documents/2023/03/01/2023-04248/telemedicine-prescribing-of-controlled-substances-when-the-practitioner-and-the-patient-have-not-had, said things like, JR writes:, this
Persians2 mentions across 2 issues

Persians is a recurring concept in the Astral Codex Ten archive, appearing 2 times across 2 issues between January 10, 2024 and February 05, 2026. The archive places it in contexts such as "Xenophon was a mercenary who fought beside Persians"; "the Persians as one of their many vassals"; "Byzantines and Persians were both exhausted from fighting each other". It most often appears alongside Byzantines, Carthage, Rome.

Article page
Persians
Mention count
2
Issue count
2
First seen
January 10, 2024
Last seen
February 05, 2026
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Source context
Book Review: Cyropaedia
January 10, 2024 · Original source
Xenophon was a mercenary who fought beside Persians, making him potentially qualified to know things about Cyrus. He was a member of Socrates’ inner circle along with Plato, making him potentially qualified to know things about political philosophy (Plato’s Republic might be a response to Cyropaedia or vice versa; classicists aren’t sure).
Cyropaedia consists of eight books, exploring themes like: Who Even Were The Persians? This question has bothered me for a long time.
Don’t say Persepolis - it was built after Cyrus’ conquests, and wasn’t even really a city as much as a ceremonial palace complex. And don’t say Pasagardae - it was also built by Cyrus. So where did Cyrus come from? Who were the pre-Cyrus Persians?
Links For February 2026
February 05, 2026 · Original source
45: Where is the original menorah from the Second Temple? We know the Romans took it when they sacked Jerusalem. We think the Vandals took it when they sacked Rome, and brought it to their capital of Carthage. The Byzantines might have taken it when they sacked Carthage, and maybe brought it back to Jerusalem? After the Persians sacked Jerusalem in 614, the trail goes completely dark, although there are the usual legends that it was hidden away, to be returned in the age of the Messiah (or something). Other people say it never left Rome, and is still hidden somewhere in the Vatican.
Inline links: Where is the original menorah from the Second Temple?
PFC2 mentions across 2 issues

PFC is a recurring concept in the Astral Codex Ten archive, appearing 2 times across 2 issues between September 30, 2022 and October 31, 2022. The archive places it in contexts such as "A 'state prediction error' or general surprise signal from PFC"; "in PFC (via the mesocortical pathway), it draws attentional resources". It most often appears alongside dopamine, fMRI, mesocortical pathway.

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PFC
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September 30, 2022
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October 31, 2022
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Highlights From The Comments On Unpredictable Reward
September 30, 2022 · Original source
One neuroscientific perspective on this is that in order for dopamine to track reward prediction *error* (RPE), it is logically necessary that some other piece of neural circuitry track reward prediction *per se*, often called "value." Those of us who think that dopamine is computing RPE on a moment-by-moment basis (the first derivative of value; see Kim, Malik et al., Cell, 2020) therefore generally also believe that some other part of the brain, especially the ventral striatum (aka nucleus accumbens) and perhaps also the prefrontal cortex, maintains an estimate of value that gets updated by dopamine. And indeed, there are dozens of papers reporting that neural firing in these brain regions correlate with value over and above RPE.
That said, it is also true that (1) NAc neurons correlate strongly with value and also respond to some extent to rewards, predicted and unpredicted; (2) cocaine or amphetamine in the NAc (and another region of the ventral striatum called the olfactory tubercle), which dramatically elevate dopamine levels, elicit robust responses; and (3) in the context of the "liking vs. wanting" framework you allude to, Kent Berridge and others have argued that the NAc contains a "hedonic hotspot", along with closely linked regions like the prefrontal cortex and ventral pallidum. This is an operational definition meaning that when you infuse opioid receptor agonists into said region, the animals react with pleasure, and conversely if you lesion/block activity in these areas, they don't show these behaviors as much, or even start showing defensive behaviors.
Now, what does the released dopamine do? In PFC (via the mesocortical pathway), it draws attentional resources to the surprising stimulus and its plausible causes, gating out the processing of other, less relevant stimuli. Simultaneously, in NAc, it strengthens connections between PFC inputs and the endorphin-releasing cells, thereby wiring together the hedonic features of the reward and the sensory features of any cues predictive of it. This imbues the cue with the ability to release the GABAergic brake on VTA DA neurons all by itself. Phenomenologically, it results in us "liking" the cue as much (or nearly as much) as we like the reward (this is what allows, e.g., animal trainers to reinforce behavior with only the sound of a clicker that has previously been paired with food).
Highlights From The Comments On Jhanas
October 31, 2022 · Original source
Now, what does the released dopamine do? In PFC (via the mesocortical pathway), it draws attentional resources to the surprising stimulus and its plausible causes, gating out the processing of other, less relevant stimuli. Simultaneously, in NAc, it strengthens connections between PFC inputs and the endorphin-releasing cells, thereby wiring together the hedonic features of the reward and the sensory features of any cues predictive of it. This imbues the cue with the ability to release the GABAergic brake on VTA DA neurons all by itself. Phenomenologically, it results in us "liking" the cue as much (or nearly as much) as we like the reward (this is what allows, e.g., animal trainers to reinforce behavior with only the sound of a clicker that has previously been paired with food).
Philosopher's Stone2 mentions across 2 issues

Philosopher's Stone is a recurring concept in the Astral Codex Ten archive, appearing 2 times across 2 issues between January 21, 2022 and April 01, 2025. The archive places it in contexts such as "working on developing the Philosopher's Stone"; "process that makes the Philosopher's Stone look like freshman chem lab". It most often appears alongside 1/28/22, ACX Grants, Afghanistan.

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Resubmit And Summarize Your Proposals For Grants ++
January 21, 2022 · Original source
Homunculus LLC is a startup working on developing the Philosopher's Stone, which would lead to universal immortality and infinite wealth. Our CEO, Nicholas Flamel, has a PhD from the University of Paris and is universally recognized for his work deciphering hieroglyphics. Our CTO, John Dee has a PhD from Oxford and served as court astrologer to Elizabeth I. We believe that precise application of quicksilver while Aries is in the ascendant is the secret to creating the Stone; you can read our white paper at homunculus.com/white-paper. We're looking for seed investments between 10,000 and 100,000 gold florins; if you think you can help, please email inquiries@homunculus.com.
The Colors Of Her Coat
April 01, 2025 · Original source
Buy the stone and retrace your path through the burning deserts and vengeful Muslims until you’re back in England or France or wherever. Still alive? That was the easy part. Now you need to go through a chemical extraction process that makes the Philosopher's Stone look like freshman chem lab. "The lengthy process of pulverization, sifting, and washing to produce ultramarine makes the natural pigment … roughly ten times more expensive than the stone it came from."
PMDD2 mentions across 2 issues

PMDD is a recurring concept in the Astral Codex Ten archive, appearing 2 times across 2 issues between March 16, 2022 and February 22, 2023. The archive places it in contexts such as "This paper confirms that women with PMDD or PPD"; "women with PMDD or PPD (but not other women) get tolerance to allopregnanolone"; "which is officially included in the DSM as PMDD (premenstrual dysphoric disorder)". It most often appears alongside 5α-reductase inhibitor, A Mindful Monkey, Africa.

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Highlights From The Comments On Zulresso
March 16, 2022 · Original source
This paper confirms that women with PMDD or PPD (but not other women) get tolerance to allopregnanolone within the normal course of the menstrual cycle or pregnancy. There’s actually a study showing that these women get less effect from benzos during this time, since the allopregnanolone and benzos have cross-tolerance!
In an elegant series of experiments, Peter Schmidt and David Rubinow gave participants a medication (leuprolide) that suppresses oestrogen and progesterone. This eliminated PMDD symptoms. Whats more, when they reintroduced either oestrogen or progesterone, symptoms returned.
Inline links: series of experiments
An RCT (n=206) of isoallopregnanolone (sepranolone) in PMDD did not beat placebo for the primary outcome. However, blocking allopregnanolone production with the 5α-reductase inhibitor dutasteride does seem to work, in a small RCT at least.
Inline links: RCT, small RCT
Book Review: The Geography Of Madness
February 22, 2023 · Original source
This image (source) of a witch stealing a man’s penis, with a box of previously-stolen penises to her right accompanies the 1411 poem “Flowers Of Virtue” in its 1486 edition. Malleus Maleficarum was published in 1486, so if the original text of Flowers Of Virtue contained the incident this picture refers to, it would predate Malleus. But the original text is written in poetic medieval German and I can’t find a good translation. When I wrote my review of the Malleus, people were surprised at the penis-stealing witch chapters. Yet nothing could possibly be less surprising; the penis-stealing witches are timeless and omnipresent. When commenters continued to doubt, I promised them this review of Frank Bures’ Geography Of Madness. II. Frank Bures is a journalist. In 2001, he came across an unusual BBC article: a mob had killed twelve people in Nigeria, believing them to be penis-stealing witches. A few months later, a similar article: five people, Benin. He tried to pitch a story about the phenomenon to his editor, who “said he couldn’t pay me to fly to Nigeria and find essentially . . . nothing”. For some reason - and this is the point at which I start to worry about narrator reliability - Bures became obsessed with this. He couldn’t get it out of his mind. He started scraping together money to visit Africa on his own, story be damned: Nigeria gnawed at me. I knew that it was a terrible time to leave. I knew that [my wife] Bridgit, newly pregnant, wouldn’t want me to go. But I also knew that I had to, and that if I didn’t it would be a lifelong regret. . . three months later, I was the lone tourist on a plane full of Nigerians descending to Lagos. Africa is a relative newcomer to penis-stealing witches: The first recorded incident of penis theft in Africa I could find took place in Sudan in the 1960s. But in the mid- to late seventies in Nigeria, there were waves of well-documented cases. One of these happened in the northern city of Kaduna, where a psychiatrist named Dr. Sunday Ilechukwu was working in his office when a policeman arrived, escorting two men. One of them said he needed a medical assessment: He had accused the other of making his penis disappear. As with [a previously discussed incident], this had caused a disturbance in the street. During Ilechukwu’s examination, he later recounted, the victim stared straight ahead while the doctor examined his penis and pronounced him normal. “Exclaiming,” Ilechukwu wrote in the Transcultural Psychiatric Review, “the patient looked down at his groin for the first time, suggesting that the genitals had just reappeared.” According to Ilechukwu, this was part of an epidemic of magical penis theft that swept through Nigeria between 1975 and 1977. “Men could be seen in the streets of Lagos holding on to their genitalia either openly or discreetly with their hand in their pockets,” Ilechukwu wrote. “Women were also seen holding on to their breasts directly or discreetly, by crossing the hands across the chest . . . Vigilance and anticipatory aggression were thought to be good prophylaxes. This led to further breakdown of law and order.” During an incident, the victim would yell: “Thief! My genitals are gone!” Immediately, a culprit would be identified, apprehended by a crowd, and often killed. …but it’s been making up for lost time. Bures was able to find and interview one previous penis theft victim, plus the friend of another. Both described similar stories: someone had bumped up against them under weird circumstances, they immediately noticed their penis was much smaller than usual, they called out the culprit, and - apparently because the witch involved didn’t want to get in trouble - their penis was restored. Whatever weird itch this topic had given Bures, this didn’t satisfy him. He writes, very lucidly, about a desire to get closer to “the story”. He started bumping up against random Nigerians in suspicious ways, hoping one of them would accuse him of stealing their penis. Bures was an obvious foreigner, and a these panics often resulted in the suspected penis-stealer getting lynched, so this was a crazy thing to do. He could easily have died. Instead, everyone politely ignored him, nothing happened, and a slightly-disappointed Bures flew back to his poor family and abandoned his weird obsession. III. …for four years. After that the bug bit him again and he flew to Asia, long a center of penis-stealing witch activity. There are nature documentaries on lions, dolphins, even dinosaurs. They all share a common pattern: you talk about your subject’s habitat, their diet, their behaviors. The Asian half of The Geography Of Madness has the feel of a nature documentary on penis-stealing witches. And the last beat of every nature documentary has to be: this majestic creature, which once roamed from one end of the region to the other, is now endangered, threatened by increasing globalization and industrial activity. This is true for the witches also. Bures’ time in Hong Kong was a bust. There was a penis theft panic there forty years earlier, and he was able to interview some of the doctors who treated it. But they all said that was long ago. Now everybody is Westernized and has Western fears like vaccine injury or structural racism. They get Western mental disorders like depression and anorexia. The idea of witches stealing their penises seems as risible to them as it probably does to you. Singapore was also a bust. Bures had hoped it wouldn’t be, because it’s full of Malaysians, and Malaysia holds a special place in history as the spot where penis-stealing witches first made contact with Western science. The Malaysian word for the condition is koro (it means “head of a turtle”, based on an analogy to the penis retracting into the body the same way a turtle’s head retracts into its shell), and it is by this name that the condition gets listed in the DSM and the rest of the medical literature. Neither I nor Bures was able to find many ethnic Malays worrying about koro; most of the activity seems to be from Malaysian-Chinese. The Chinese definitely worry about it, attributing it to a wide variety of causes including poisoning, yin-yang imbalance, and - yes - witches. But Bures found nothing among any ethnicity. Once again, all the doctors said it used to be common, but disappeared as the city industrialized and adopted Western ways. Guangzhou was also a bust. The doctors said the same thing - in the old days, there would be huge epidemics of koro, social contagions that would impact hundreds of people at once. Now only a few superstitious rural people still believed. One traditional healer said he saw “three or four” cases a year. All the educated people had moved on. I once saw a nature documentary on Tasmanian tigers. Most people believe these have been extinct since 1930. Still, there are occasional unconfirmed sightings, especially in a remote area called Cape York, and every so often some scientists trudge off to Cape York with traps and cameras in the hopes of getting lucky. Bures decides end his own nature documentary with an expedition to the Cape York of the penis-stealing witches. This is a remote island village in China called Lin’gao, where in 1984: . . . rumors spread of a fox ghost - sometimes disguised an old woman roaming the land—collecting penises in covered baskets she carried on a shoulder pole. When two young men approached her and told her to uncover the baskets, they looked inside, saw that the baskets were filled with penises and died instantly of fright. Panic about koro would hit a village and last three to four days. When residents heard about a case in a neighboring village, the panic would subside, since that meant the ghost had moved on. The attacks slowly made their way around the island. The ghost struck at night, when villagers were sleeping. A chill would creep into the room, and suddenly the victim would feel his penis shrinking inward. He would grab it and run outside for help. A twenty-eight-year-old office worker was at home one night when: > “ . . . he heard a gong being beaten and the terrifying noises made by people who were panicking in a nearby neighborhood. He suddenly became anxious and experienced the sensation that his penis was shrinking. He was seized with panic and shouted loudly for help. Several men in the neighborhood rushed in and tried to rescue him by forcefully pulling his penis and making loud sounds to chase away the evil ghost that was thought to be affecting him.” Neighbors and family members were enlisted in rescue operations. Victims were beaten with sandals and slippers while the middle finger of their left had was squeezed, so that the ghost could exit the body there. The epidemic engulfed the island, with the exception of the Li and Miao minorities, who seemed to be immune to such fears. Researchers estimated that between 2,000 and 5,000 people were affected, but that “no one died from genital retraction.” One baby, however, did die when his mother tried to feed him pepper juice, and a girl was beaten to death during a two-hour exorcism. “Numerous men suffered injuries to their penises as a result of ‘rescuing’ actions.” Iron pins were sometimes inserted through the nipples of women to prevent retraction, which caused infections as well. This was, as far as anyone knows, the last great koro epidemic in Asia. Bures had a terrible time getting to Lin’gao. He had equal trouble getting an interpreter; the natives spoke a language called Be, very distantly related to Thai but not at all to regular Chinese. Finally he found someone who was able to contact a local shaman. Like any good doctor, the shaman referred him to a specialist - in this case, the designated anti-ghost shaman, who lived in a different village. He spent most of his time off on various ghost-fighting missions, but eventually Bures and his team were able to track him down. I want you to picture the scene. An American journalist has been traveling the world in search of a dying variety of witchcraft. Now he’s reached the end of the line, the wildest and most primitive region of China. With great difficulty, he has procured an interpreter. Together, they consult a shaman, who sends them on a quest to find a second, wiser shaman who specializes in ghosts. After many trials and tribulations, he reaches the second, wiser, ghost-specialist shaman, who invites him into his home, filled with strange charms and magical images. “Tell me your question,” says the shaman. And Bures asks: “What do you know about penis-stealing witches?” . . . and the shaman answers: “Haha, no one believes in that stuff anymore.” IV. So as a nature documentary, The Geography of Madness is kind of a bust. Still, Bures rescues it with some great analysis of culture-bound mental illness. A culture-bound mental illness is one that only affects people who know about it, and especially people who believe in it. Often it doesn’t make sense from a scientific point of view (there’s no such thing as witches, and the penis can’t retract into the body). It sometimes spreads contagiously: someone gets a first case, the rest of the village panics, and now everyone knows about it / believes in it / is thinking about it, and so many other people get it too. Different cultures have their own set of culture-bound illnesses. Sometimes there are commonalities - many cultures have something something penis something witches - but the details vary, and a victim almost always gets a case that matches the way their own culture understands it. THESE PEOPLE ARE NOT MAKING IT UP. I cannot stress this enough. There are plenty of examples of people driving metal objects through their penis in order to pull it out of their body or prevent the witches from getting it or something like that. There is no amount of commitment to the bit which will make people drive metal objects through their penis. People have died from these conditions - not the illness itself, which is fake, but from wasting away worrying about it, or taking dangerous sham treatments, or getting into fights with people they think caused it. If you think of it as “their unconscious mind must be doing something like making it up, but their conscious mind believes it 100%”, you will be closer to the truth, though there are various reasons I don’t like that framing. In Rajasthan, India, people come to the hospital with gilahari (lizard) syndrome. Patients say a lizard-like mass, sometimes visible as a skin swelling, is crawling around the body. They express terror that it will reach their airway and suffocate them. Japanese people may contract jikoshu-kyofu, a debilitating fear that they have terrible body odor. No amount of reassurances by friends and psychiatrists can convince these people that they smell normal, nor will any number of deodorants or perfumes make them comfortable. The French suffer from bouffée délirante, where a perfectly healthy person suddenly becomes completely psychotic, with well-formed hallucinations and delusions - then recovers just as suddenly, sometimes over hours or days. This is not how psychosis works anywhere except France and a few former French colonies. Traditional Chinese medicine monitors the balance between yin and yang. The male orgasm can deplete yang, and sure enough in China (but nowhere else) some men suffer traditional symptoms of yang depletion after they orgasm. “The symptoms can last weeks to months after a single orgasm, [and include] chills, dizziness, [and] backache”. The phrase “run amok” comes from Malaysia, where it referred to a specific phenomenon: some person who had been unhappy for a long time would suddenly snap, kill a bunch of people, then say they had no memory of doing it. Malaysian culture totally rolls with this and doesn’t hold it against them; the unhappiness is a risk factor for possession by a tiger spirit, which commits the killings. Although Malays have been doing this since at least the 1700s, there are some fascinating parallels with modern US mass shootings that suggest the damn tiger spirits have finally made it to the US common psychological origins. I have seen exactly one demonic possession case in my ten years as a psychiatrist. The man fell to the ground, mouth foaming, chanting strange syllables and the names of Biblical demons. My attending doctor at the time - one of those people who somehow manages to be an expert in everything - was an expert in demonic possession, and told us that he was in no way psychotic, antipsychotics wouldn’t help him (except insofar as they help everyone by decreasing all behaviors), and he needed to “work through his issues”. The patient was uncooperative - he was only visiting MDs because the local bishop wouldn’t call in an exorcist until he got a psych exam - and eventually left against medical advice. After going down the list, Bures asks the correct next question: how do we know whether or not our own mental illnesses are just as culture-bound as the Japanese or Malaysians’? Cultures that believe in witches have witch-related culture-bound illnesses; cultures that believe in demons have demon-related ones. We believe in science, so we should expect sciencey-sounding culture-bound illnesses, and these might be hard to tell apart from other, more physical conditions. So how suspicious should we be, and of what? Certainly we have some culture-bound mental illnesses. Electromagnetic hypersensitivity is a condition where some people supposedly become very sick when exposed to electromagnetic fields (like from cell phones). This sounds very scientific and makes perfect sense according to our culture, but researchers have found that placebo electrical devices make them exactly as sick as real ones, and that devices they don’t know about don’t make them sick at all. These people’s pain is real, and their lives are very difficult (although a few have found refuge in the National Radio Quiet Zone, an area in Virginia where the government enforces a ban on electromagnetic transmissions for secret military reasons). But their condition only afflicts them because they believe in it, much like with koro. Fine, everyone knows that one’s not real. What about DSM-style mental disorders, the stuff everyone’s supposed to believe in? Are those culture-bound? Unfortunately, I think Bures kind of flubs this section. He decides to focus on PMS (premenstrual syndrome), which is officially included in the DSM as PMDD (premenstrual dysphoric disorder). After discussing the history of hysteria, he writes that: Today, hysteria is never diagnosed, except by unwise husbands. In 1931, however, an American gynecologist named Robert Frank revived the idea in a new guise. He published an article titled, “The hormonal causes of premenstrual tension.” Frank described symptoms that occurred in the week before menstruation: irritability, bloating, fatigue, depression, attacks of pain, nervousness, restlessness, and the impulse for “foolish and ill considered actions,” due to ovarian activity. Again, the cause was the uterus. Then in 1953, British physician Katharina Dalton elaborated on this, arguing the condition came from fluctuation of estrogen and progesterone. She called it Premenstrual Syndrome, and soon symptoms grew to include: anxiety, sadness, moodiness, constipation or diarrhea, feeling out of control, insomnia, food cravings, increased sex drive, anger, arguments with family or friends, poor judgment, lack of physical coordination, decreased efficiency, increased personal strength or power, feelings of connection to nature or to other women, seizures, convulsions, asthma attacks, not to mention flare ups in asthma, allergies, sinusitis, anxiety disorders, irritable bowel syndrome, migraines, and multiple sclerosis. If any of these symptoms occurred in the second half of the menstrual cycle, one had PMS. Estimates of the number of women afflicted ranged from 5 percent to 95 percent. In the 1980s, three women in the UK were tried for arson, assault and manslaughter. The three all claimed they had diminished responsibility due to PMS, and got reduced sentences on the condition that they underwent hormone treatment. After that, according to one study, American women flooded doctors with requests for help with their PMS. “Popular groups like PMS Action were founded to promote recognition and treatment of PMS by medical professionals. Private PMS clinics began to appear in the USA, modeled after those in the UK, and progesterone therapy was enthusiastically adopted, much to the chagrin of many gynaecologists who viewed its use as ‘unscientific’ and ‘commercial’, not to mention unlicensed." Based on all this, the 1987 version of the DSM-III included a new category: Late Luteal Phase Disorder (luteal refers to progesterone). It was proposed as a topic for further research, but despite the absence of such research, it was included in the 1994 edition of the DSM-IV under the name Premenstrual Dysmorphic Disorder, or PMDD.96 In 2013, in the DSM-5, it was given its own category as a full-fledged mental illness. Yet neither PMS nor PMDD occur in most cultures. There are no biomarkers to measure them by. No conclusive correlation has ever been found between estrogen or progesterone levels and PMS. As one study noted, “the more time that women of ethnic minorities spend living in the United States, the more likely they are to report PMDD. Thus, if we are to accept PMDD as a reified medical disorder, then we must also accept exposure to U.S. culture as a risk factor for contracting PMDD.” If it is a syndrome at all, it’s a cultural one. I asked my wife what she thought of this, and she told me: The day before her first-ever period, as a teenager, when she had never really thought about PMS, she felt exceptionally weird, emotional, and generally off, to the point where it seemed to demand an explanation. Then she had her first-ever period, and retroactively explains it as PMS.
Inline links: source, my review of the, Geography Of Madness, Be, gilahari (lizard) syndrome, jikoshu-kyofu, bouffée délirante, suffer traditional symptoms of yang depletion, run amok, Electromagnetic hypersensitivity, National Radio Quiet Zone
She reminded me that yesterday she was unusually grumpy, so much so that she had apologized to me for it and tried to come up with explanations - and then later yesterday she had her period. Meanwhile, Bures’ counterargument is - what? That it sounds kind of sexist to accuse female hormones of making women overly emotional? Hasn’t he ever heard of stereotype accuracy? That people asked their doctors to be treated for it more often after they knew it was considered a medical condition, and was treatable? That seems to have a much simpler explanation! That there are no biomarkers? There are inconsistent biomarkers that work sometimes but not other times, just like for schizophrenia, epilepsy, cancer, and half the other conditions in medicine. That these conditions don’t occur in most cultures? From here: A World Health Organization (WHO) study on menstruation (1981) surveyed 5,322 women from Egypt, India, Indonesia, Jamaica, Korea, Mexico, Pakistan, Philippines, United Kingdom and Yugoslavia. . . The majority of women in all cultures report some premenstrual physical discomfort in addition to negative mood changes, however fewer women report mood change than physical change. The main cross-cultural difference was in the prevalence of specific symptoms. Immigrants to the United States report more PMDD the longer they’re here? True (source), but it’s a matter of degree, and seems more true of the PMDD diagnosis than specific symptoms. The diagnosis requires impairment, which is subjective. I imagine an immigrant from a culture where mental disorders are unthinkable - something that only happens to a few psychos in asylums - and where you work 12-hour days in sweatshops. Someone asks her “hey, has this mental disorder ever prevented you from working?”, and she says no, because obviously you grit your teeth and work through the symptoms. And I imagine an American seeing the same question and saying “Yeah, I did decide I had to take a couple of sick days because of that.” I’m not saying this definitely happened, just that it’s a possibility. Meanwhile, this entire area of study is a mess. The “PMDD is culture-bound” hypothesis was originally invented by feminist scholars trying to argue that the diagnosis was a sexist attempt to pathologize women as overemotional and untrustworthy (this is also where Bures got his “it’s just hysteria by a different name” idea). See for example here and here, the second of which says that “the feminist argument is that if women are angry/distressed, it is for good reason, not due to pathology”. Bures somehow swallowed and repeated this, and then some feminists on Vox wrote an article attacking him as a “male writer” who was denying women’s lived experiences of PMS and stereotyping them as stupid and gullible. Neither side has an argument beyond “I can think of a reason it would be sexist for people to disagree with me” and neither side will acknowledge that the other side is also feminists basing their argument entirely on how it would be sexist to disagree with them. Everything in every area of social science has been like this for at least the past twenty years. But also, this highlights the difficulties with declaring something culture-bound. How do you know if something’s culture-bound, vs. people don’t notice it or mention it if they don’t have a name for it? How do you know if something’s culture-bound vs. some cultures consider it too embarrassing or taboo to think about? How do you know if something’s culture-bound, vs. people will go to doctors about it if they think doctors can treat it, and otherwise they won’t? I’ll discuss these questions more later, but I want to finish Bures’ argument. He gestures at a few other possible candidates for culture-bound mental disorders, including repetitive strain injury and chronic pain. But he quickly moves on to a long section that tries to establish the reality of “voodoo death”, ie the thing where if you believe you are going to die hard enough, you actually die. I think most arguments for voodoo death are pretty bad, and I didn’t find Bures’ convincing. But bonus points for referencing a study claiming that chronically stressed people only die at higher rates if they believe chronic stress is bad for them, and if not then they don’t (this is not really how I interpret the abstract, but I haven’t looked closely) Is it weird to stay on the crazy train long enough to agree that cultural effects are strong enough to make you think witches are stealing your penis, and then get off it once people start talking about voodoo death? I think no - these are very different situations. Believing in koro can make you hallucinate that your penis is shrunken or gone, but no belief, however strong, can (directly) remove your penis itself. Culture → beliefs is fine; culture → reality is a step I’m not willing to take. V. Since I rejected Bures’ PMDD example, I want to digress to what I think is a stronger argument: anorexia, which Ethan Watters discusses in his book Crazy Like Us. Anorexia was mostly unknown in the West, until becoming “trendy” in the mid-1800s. During that period, doctors reported high prevalence of anorexia among “hysterics”, but the fad ended after about ten or twenty years, and it went back to being basically unknown. In 1983, famous singer Karen Carpenter died of anorexia, thrusting it back into the national news, and suddenly lots of people (in the West) were anorexic again. Meanwhile, foreign doctors who trained in the West went back to their home countries, searched far and wide for it, and found almost nothing. The few cases they did see didn’t resemble the typical Western version at all - for example, one Hong Kong psychiatrist was able to find a woman who refused to eat out of grief when a boyfriend left her, but she didn’t think she was fat, or feel any cultural pressure to be thinner. The absence of anorexia abroad was especially surprising since anorexics tend to end up in the hospital with extremely noticeable malnutrition that doesn’t really mimic anything else. It’s not really possible to hide severe anorexia the way you can hide severe depression. In 1994, Hong Kong got its own Karen Carpenter - a young girl died of anorexia, setting off a national panic and many public awareness campaigns. Near-instantly, anorexia rates shot up to the same level as the West, with the appropriate number of people presenting to hospital ERs with severe malnutrition. This story raises a lot of questions. For example: where did the first anorexics (Karen Carpenter, the girl in Hong Kong) come from? Why anorexia and not something else? And how come knowing about anorexia makes it spread so quickly? VI. Past this point I’m using this review to discuss my own thoughts, not Bures’ or Watters’. “Culture-bound” is less all-or-nothing than you’d think. Look hard enough, and you’ll find people having “culture-bound syndromes” from cultures they’ve never heard of. Ntouros et al in Thessaloniki describe “koro-like symptoms in two Greek men”. One, a paranoid schizophrenic: . . . reported for the first time a sensation that his penis retracts into the abdomen and a fear that it will subsequently be lost. This would be accompanied by anxiety and sadness pertaining only to the loss itself. He would then proceed to search manually for his penis and masturbate. No pleasure was gained by masturbation, but the anxiety would be lifted. Romero et al describe a case of koro in "an intellectually disabled Caucasian patient" in Spain. They write that "although it is widely regarded as an epidemic in South-east Asia, there are some isolated cases in other cultures as well." Wilson and Agin describe a 29 year old white male from New York, "not exposed to the Chinese culture”, who went to the doctor with a five month history of worrying that his genitals were retracting into his body: Sometimes, he would manually reaffirm the presence of his genitals. Occasionally he would, in private, remove his garments and visually confirm the presence of his genitals. On one occasion, while taking the train home from work, he experienced an acute exacerbation of these symptoms. His pain increased from 3/10 to 10/10, and he felt as if his genitals had fully retracted within his belly. Upon reaching his hometown, he immediately went to the local hospital emergency room where examinations for inguinal hernia, urinary tract infection, proctitis, prostatitis, and testicular disorders proved negative. He improved significantly on the anti-anxiety medication desipramine. Chowdhury surveys the evidence on koro and divides the condition into two types: culture-bound and non-culture-bound. The culture-bound type usually goes in large epidemics, hundreds to thousands of people, in koro-believing parts of Africa and Asia; the victims were usually previously psychologically normal. The non-culture-bound type hits a few scattered individuals, is not contagious, and can happen anywhere - Greece, Spain, America. Some patients are psychologically normal, but there are a disproportionate number of schizophrenics, drug users, brain damage victims, and other previously-mentally-ill people. Other culture-bound illnesses seem to be like this too. Running amok has been big in Malaysia for 300 years. The Columbine shooters seem to have been autocthonous American cases, equivalent to that one New Yorker who got koro - before their fame inscribed amok onto the US collective consciousness the same way Karen Carpenter’s inscribed anorexia. Japan’s jikoshu-kyofu affects occasional victims in the US under the name olfactory reference syndrome. Watters admits there were a tiny handful of unusual anorexia cases in Hong Kong before Westernization. And even that Indian there’s-a-lizard-in-my-skin condition differs only in species from delusional parasitosis. Delusional parasitosis - the false belief that you are infested with parasites and can feel them crawling in your skin - is actually an especially interesting case. Two groups are disproportionately represented among patients: menopausal women and cocaine addicts. Relatedly, two biological conditions that can sometimes cause weird skin sensations that feel like crawling insects are . . . menopause and cocaine use. So there’s no mystery here. But, also represented among delusional parasitosis patients are the roommates and family members of these people. The index case hallucinates insects for a well-understood biological reason; their close contacts hallucinate insects through social contagion. So a unified theory of these conditions might be: Some people have the condition for a normal biological or psychiatric reason. For example, someone might believe a lizard is crawling under their skin because they use cocaine, which causes hallucinatory crawling sensations. Or someone might believe their penis is missing because they’re schizophrenic, which makes them naturally hallucination-prone.
Inline links: stereotype accuracy, inconsistent biomarkers that work sometimes but not other times, here, source, here, here, and then some feminists on Vox wrote an article, chronic pain, are pretty bad, a study, Ethan Watters discusses in his book, Ntouros et al, Romero et al, Wilson and Agin, surveys the evidence, olfactory reference syndrome, delusional parasitosis
Pokémon2 mentions across 2 issues

Pokémon is a recurring concept in the Astral Codex Ten archive, appearing 2 times across 2 issues between July 14, 2023 and April 01, 2025. The archive places it in contexts such as "Pokémon takes the tool of “collections” and turns it into an international obsession"; "it can’t even beat Pokémon yet, a game many of us conquered". It most often appears alongside England, Erik Hoel, Pokémon.

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Pokémon
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2
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July 14, 2023
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April 01, 2025
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Your Book Review: The Educated Mind
July 14, 2023 · Original source
That is to say: these aren’t stages we move through, they’re Pokémon we collect. And the goal — of course! — is to collect ’em all.
Pokémon takes the tool of “collections” and turns it into an international obsession. I feel like the more people learn to use these tools, the more money they can make. We’re Egan-izing everything.
The Colors Of Her Coat
April 01, 2025 · Original source
This is what I fear most about AI, at least in the immediate future. Not some superintelligence that eats the world (it can’t even beat Pokémon yet, a game many of us conquered at ten). Rather, a less noticeable apocalypse. Culture following the same collapse as community on the back of a whirring compute surplus of imitative power provided by Silicon Valley. An oversupply that satiates us at a cultural level, until we become divorced from the semantic meaning and see only the cheap bones of its structure. Once exposed, it’s a thing you have no relation to, really. Just pixels. Just syllables. In some order, yes. But who cares?
polio2 mentions across 2 issues

polio is a recurring concept in the Astral Codex Ten archive, appearing 2 times across 2 issues between July 21, 2021 and May 21, 2024. The archive places it in contexts such as "It would be like a land that was convinced it had the best vaccine for polio"; "we displayed when eradicating smallpox, polio, and all the other causative agents for dangerous medica". It most often appears alongside Crazy Like Us, 9/11, ACOUP.

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polio
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2
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July 21, 2021
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Highlights From The Comments On "Crazy Like Us"
July 21, 2021 · Original source
I found the trauma section of the book very compelling, in part because it squares with my impression of the United States as a society that is convinced it understands trauma better than any previous society but seems to achieve uniquely poor outcomes. It would be like a land that was convinced it had the best vaccine for polio but you look around and every fourth person is in an iron lung.
Book Review: The Others Within Us
May 21, 2024 · Original source
Falconer treats our Eurocentric individualistic citadel mind as a terrible historical mistake, in which a whole continent foolishly amputated its capacity for spiritual experiences. I think of it as more of a triumph: realizing on some level that belief in demons made them real, we eradicated that belief with the same fervor that we displayed when eradicating smallpox, polio, and all the other causative agents for dangerous medical conditions.
political science2 mentions across 2 issues

political science is a recurring concept in the Astral Codex Ten archive, appearing 2 times across 2 issues between June 24, 2022 and June 07, 2023. The archive places it in contexts such as "mandatory reading for IR/political science freshmen"; "he’s making some kind of deep Political Science point". It most often appears alongside American, China, Japan.

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political science
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Your Book Review: Public Choice Theory And The Illusion Of Grand Strategy
June 24, 2022 · Original source
It is very much an academic book that should revolutionise the whole field of IR by challenging the fundamental assumption of realpolitik with impressive rigour, so the brisk 200 pages should probably be mandatory reading for IR/political science freshmen. Like Robin Hanson, I would have been persuaded by an article length analysis, but as Hanania himself agrees, the belabouring book length treatment is to disabuse academics who by nature demand sweat and impressive mastery of literatures — this review should, dare I say, suffice for the cynical reader.
Inline links: Robin Hanson, Hanania
Assistant Dictator Book Club: America Against America
June 07, 2023 · Original source
He says this a lot, and sometimes it sounds pretty profound and like he’s making some kind of deep Political Science point. But I think he mostly means two things.
What prevents me from dismissing it in this way is that, well, China sure is trying the project of having the first set of things but not the second set. In the early 2000s, everyone in the West thought China would inevitably democratize; surely it was impossible to for a rich, technologically advanced nation of the sort China was becoming to remain a pseudo-communist autocracy. This seems a lot like the theory that America’s prosperity and its decadence are two sides of the same coin. If Wang took power in China to test his theory that freedom and prosperity were separable, his experiment has been one of the most impressive and conclusive in political science.
polyamorous2 mentions across 2 issues

polyamorous is a recurring concept in the Astral Codex Ten archive, appearing 2 times across 2 issues between May 11, 2023 and February 21, 2024. The archive places it in contexts such as "polyamorous people ... had more Long COVID"; "you could use “polyamorous” synonymously with “people who don’t really love each other”". It most often appears alongside Scott, 15th Commandment, 2017 SSC survey.

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Highlights From The Comments On Long COVID And Bisexuality
May 11, 2023 · Original source
I checked to see if people who identified with other vague categories had more Long COVID. This was mostly true for left-leaning or weird categories, and mostly false for right-leaning or normal categories. For example, Christians and Republicans had no more Long COVID than people who said no religion or no political party, but polyamorous people and rationalists did. The strongest effect was for ambidextrous people, but ambidextrous people also have more mental illness.
There were a few exceptions - polyamorous people, rationalists, and (to a much lesser degree) effective altruists all had higher Long COVID too. But these groups also have higher rates of bisexuality and mental illness; I think they are just weird.
As we saw above, certain weird-identity havers like polyamorous people and rationalists did have more Long COVID, but I attributed that to being part of the same cluster of genuinely weird people as bisexuals.
Highlights From The Comments On Polyamory
February 21, 2024 · Original source
I feel like a simpler rebuttal to such an article would be statistics comparing relationship happiness/satisfaction in polyamorous people and monogamous people. Does no such comparison exist which is why one must resort to reviewing n-of-1 studies or raising concerns about people deriving generalizations from a handful of n-of-1 studies?
You can read a list of all her findings here. In all questions, monogamous people answer about their partner, and polyamorous people answer about their primary or longest-term partner. The ones that I found most interesting were these:
Inline links: here
In general, polyamorous people were as happy with and committed to their relationship as monogamous people, and people “in the middle” were less happy than either. Aella thinks (and I agree) that this means that people who are genuinely committed to one relationship style or the other will do better than people who are “trying to open up the relationship” as a last-ditch move, or conflicted, or implementing a messy compromise between partners with different values. Here are some other graphs that focus on relationship length: The relationship length graph here at the bottom seems to slightly contradict the one above showing similar length; I think this is partly because there aren’t enough 45-55 year olds in the sample to make a difference in the aggregated data, and partly because I think the bottom graph combines “slightly poly” and “very poly” into a single “poly” category, and we already saw that slightly poly people do badly. To a first approximation, poly people are equally happy with and committed to their partner as monogamous people, regardless of relationship length (though remember that this selects for relationships that are still going on), and they get married at about the same frequency. However, they only have about half as many children. This broadly matches the results of the 2017 SSC survey (I’m using 2017 because it had the most questions on sex and relationships). Mono and poly people had equal self-rated life satisfaction, but poly people had higher romantic satisfaction (6 vs. 6.6). Poly people were slightly less likely to currently be in a primary relationship that had lasted more than five years (34% vs. 39%), but this might be because they were slightly younger (31 vs. 33). Respondents were mostly young and childless, but poly people were only half as likely to have children as mono people (15% vs. 27%). I think a fair summary of these results is “poly and mono relationships are about equally good, except that poly people have slightly higher romantic satisfaction and mono people are much more likely to have children; being wishy-washy in the middle is worse than either”. Hamish Todd (blog) writes: I was poly for two years or so then stopped. Jealousy, in the sense of feeling bad because someone was sleeping with my partner, wasn't a problem for me. I will say what the problems were, and I'll be interested to see responses/links to responses. I hung out in two polyamorous friendship groups: one was good but very small and not much happened. The other was large, and it was *awful* to be in for a man - to be blunt, because competition for females ended up happening two-faced way - "oh it's so great to see you man!" - while not actually having any interest in one another. I don't think the women were always aware of it (my primary partner certainly wasn't). The problem polyamorous communities have that modal-person-is-monogamous communities does not is that men get an extra incentive to interact with other men: that incentive is a chance of sleeping with your partner. This makes for more shallow interactions. To say a possibly-related and by-no-means-original thing: polyamory probably makes it so that more attractive men have extra sex, while less attractive men have relatively less extra sex. It seems plausible that this makes men, on average, more miserable (I appreciate this is related to jealousy of course, but not quite the same, because it's not focussed on one person, i.e. one's partner). I could be wrong about that part - but if you think I am wrong, and that's why you favour polyamory, please let this be a hill you would die on, that is, if I can show you that polyamory leads to misery of this kind, you have to give me that polyamory is therefore bad. I can understand people disliking the principle that some (attractive) people should have their personal lives limited in order to make life a little happier for less attractive ones, but sometimes that's what it looks like to decrease misery. With respect I also think Scott is not the perfect person to listen to about this, simply because is at the top of a status hierarchy and the people whose welfare I am concerned for are not there. I'm not a person who thinks poly will be ruinous by the way - even without it there seem to be lots of reasons people are moving away from committed relationships with an eye toward having children. But I don't think it's good. Sounds like a testable claim! I decided to operationalize this as "on the SSC survey, polyamorous men would have a higher correlation between self-rated social status and self-rated romantic satisfaction than monogamous men". Among monogamous men (n=5268), the correlation was 0.323 Among polyamorous men (n=555), the correlation was 0.311 I'm eyeballing this as not a significant difference, and in either case it's in favor of poly. drosophilist writes: On average, straight men and straight women differ in their sexual/romantic preferences. For obvious evolutionary reasons, men's sexuality is optimized for variety/novelty/as many partners as possible, while women's sexuality is optimized for emotional attachment/find the best man you can and get him to stick around and help care for your babies. (Obvious disclaimer: I'm talking about trends and averages, not every man/not every woman, blah blah blah.) For this reason, I'm worried that a widespread embrace of polyamory/open relationships would be a disaster for women. Sure, you'll say that polyamory is all consensual and based on negotiated agreements, so what's the problem? But it's not so simple, and people who are emotionally entangled find it hard to make logical choices, and people are good at lying to themselves. "I can totally accept polyamory as the price of holding onto the man I love! [six months later] I'm so jealous and miserable and I keep hiding in the bathroom so he won't see me crying, but all open-minded people do polyamory nowadays, I can't let this get to me, I'm with the man I love, this is totally the right choice... excuse me while I get another box of tissues..." If polyamory catches on in society at large, we'll see, at minimum a lot of tearful letters to advice columns from women saying things like, "Dear Abby, my husband wants to open our marriage, I really hate the idea of him being with another woman but I don't want to be an old-fashioned prude, plus I'm afraid he'll leave me unless I agree, but the thought makes me so unhappy, what should I do?" In the canonical poly survey, women were over-represented in polyamory; about 35% of poly people were men and 49% women (the remainder either didn’t answer or were nonbinary or something). Commenters agreed with this, and said their experience was that polyamory was mostly female-driven. This is my story too; I became poly because the woman I wanted to date at the time was. Why should this be, since men traditionally prefer sexual variety more than women do? I think one thing a lot of commenters are missing is that - despite people’s salacious dreams of what it must be like - polyamory usually focuses on the emotional aspect of relationships rather than the sexual. If someone wants to sleep with a bunch of people, they can just be a normal casual-sex-haver or swinger or something. Poly emphasizes the part where you have multiple relationships. This is more of a female fantasy than a male one, hence the female predominance. There were a lot of you who were pretty sure that polyamory had to be bad in some way under some conditions. I challenge you to operationalize this in a way that we can test on future (or existing) surveys, eg “Poly people in the bottom quintile of status will report lower relationship satisfaction” or “Poly marriages among people without a college degree are more likely to end in divorce than monogamous ones.” 2: Comments I Will Argue Against Despite Not Having Statistics, Sorry Some Guy (blog) writes: I had one of those childhoods that was so terrible that people find it fascinating but this seems just awful for kids. Again, I’m probably bias because my parents have racked up close to ten marriages between them and I grew up knowing that their first and most heartfelt loyalty was never to me. There would be my brothers and sisters, whichever of my parents we were with, and just some random person they’d decided they loved more than us. And that person definitely made their resentment of us known and usually made whichever of my parents was there perform some sort of loyalty test. Most other people I know in this situation have some kind of similar experience even if the examples are less dramatic and more open to being interpreted as over-sensitivity. Say what you will about monogamy but it makes lines of loyalty very clear within a family unit. That might not matter as much when there are resources to go around for everyone, but when you’re poor it matters a lot because there isn’t that much to go around and one year your step-mom might want to ritually humiliate you and your siblings by giving you socks at Christmas while her children open elaborate gifts. Again, personal experience, blah blah blah. But you have to acknowledge that the pathways for this kind of thing open up just because you’ve expanded the numbers of players in the game and unaligned their motivations. I take the opposite lesson that Some Guy does from this. Quick digression: in medical studies, lots of people don’t take the experimental drug the way they’re supposed to. Maybe they get side effects and stop, or they screw up the dosing. There are two statistical ways of dealing with this, called “per-protocol” and “intention-to-treat”. In per-protocol analysis, only the people who took the drug correctly get counted. In intention-to-treat analysis, everyone who was assigned to the experimental group gets counted, even if they didn’t take the drug. So, suppose that you have some drug which always cures a disease when you take it correctly, but it’s incredibly complicated to get right, and has lots of side effects and almost nobody ever makes it to the end of a course. In per-protocol, the drug looks great; in intention-to-treat, it looks useless. Which is the better analysis strategy? It depends on what you’re using the number for. If you’re a patient, and you’re confident that you are smart and determined and can use it correctly, and you want to know your chances, use per-protocol. If you’re a social engineer, and you want to know how many cases of the disease you’ll cure by promoting the drug in the general population, use intention-to-treat. I find this a useful lens to apply to social problems. For example, G.K. Chesterton famously said that “Christianity has not been tried and found wanting, it has been found difficult and left untried.” Supposing he’s right, maybe Christianity, when followed per-protocol, has a strong success rate in curing sin. But it looks much worse under intention-to-treat. If you assign people to the “Christianity” group - maybe by raising them in a Christian society where you tell everyone to be Christian, and where everyone goes to church on Sundays - then most people don’t follow the protocol, and they don’t become any less sinful. Some Guy is talking about people assigned to the monogamy group. They were raised in a society that told them to be monogamous. They agreed to be monogamous. They probably had lovely weddings where they swore to be monogamous until death do them part. But it doesn’t sound like they were able to follow the protocol. Monogamy followed per protocol may have many good effects. But by intention-to-treat, monogamy looks pretty mediocre. (nobody in this story was assigned to the polyamory group, and nothing in it speaks at all to the success or failure thereof) Another way to think of this is as different failure modes: The question isn’t whether the success mode of mono is worse than the failure mode of mono. It’s whether moving the marginal couple from mono to poly or vice versa makes success more vs. less likely. I’m not sure what the answer is there. If you’re very optimistic, you could imagine that the people in the story above, instead of divorcing to be with another partner, could have stayed married, stayed with their children, and had another partner on the side. I’m not that optimistic. The people described don’t seem like they would be very good at any form of relationship. If you tell them to be monogamous, they will cheat. If you tell them they can have as many relationships as they want as long as they do so ethically and honestly, then they’ll do it unethically and dishonestly. But occasionally, I do meet some people who I feel would be better served by polyamory. Here’s a conversation I sometimes imagine having with certain friends and/or patients (this is partly stitched together from a few real conversations with different people, and partly imaginary): ME: So, you’re having a messy divorce. THEM: Yeah. ME: Because you cheated on your fourth husband. THEM: Yeah. ME: And now you’re dating a new guy. Are you worried that this might also end with you cheating on him? THEM: No. ME: Remember how we talked about the secret ancient rationalist technique of thinking about an answer for five seconds before you give it? I want you to try that now. Are you worried that this new relationship will end with you cheating on your partner? THEM: . . . . . yes. ME: Okay. Why do you think that is? THEM: I guess I’m just a bad person! ME: Can you be more specific? THEM: I guess I’m just really impulsive, and sometimes I see someone and can’t hold myself back! I’m too flighty and horny to ever be happy staying with the same guy for too long. ME: Okay. Can you think of ways that you could potentially address that in your next relationship? THEM: No, I’ve already tried therapy, and I’m too extraverted to be happy never going to any places where I could meet new men. I don’t know what else to try! I guess I’ll just never be able to be in a relationship without destroying it. ME: How would you feel about talking to this new guy you’re dating and telling him all this? Maybe he would be willing to agree to some kind of open relationship, so that if you felt something like this again, you could have a safe outlet that wouldn’t destroy the relationship. THEM: No that would be unethical. I’ve also met some people in the same situation as the “them” above who did switch to open relationships and it did seem to let them have a stable life / marriage / family in a way that they weren’t able to do before. I don’t think this is right for everyone, but the people who need it, need it. And here’s the kind of thing I see in relationship advice forums: I used to hate when my wife went out to parties or conferences because I always worried she was meeting other men. I told her she couldn’t leave the house unless she texted me exactly where she was going and explained why it was necessary, and it made her mad, but she eventually agreed. But she still talks on the phone to this one guy she’s been friends with since grade school. They’ve never had sex or anything, and he’s married to someone else, but they chat on the phone a couple of times a week and I always hear her laughing. I think it counts as an emotional affair and I told her that if she didn’t cut off all contact right away, I was going to end the marriage. Now she’s all mad at me. What should I do? This just seems like a fundamentally unhealthy outlook on relationships and life. People with better emotional skills can figure out some middle ground where they still agree not to have “emotional affairs” or whatever but don’t freak out every time their partner has contact with another human, but seeing the version where this goes bad has kind of radicalized me. I think there’s something really attractive about being poly even if you never get around to having any other relationships, just so you don’t have to constantly be getting angry at your partner for having normal human desires. TGGP writes: The real reason to prefer monogamy is that most cultures/societies have been polygynous, but the smaller number of monogamous ones were the winners in the contest of cultural group selection. I’m nervous about cultural selection arguments because they seem to justify anything, and to rapidly switch what they justify. Three thousand years ago, a cultural selectionist could have said that most societies in the world were polygynous, so we should avoid monogamy. A hundred years ago, they could have said that most societies in the world were monarchies, so we should avoid democracy. The problem is that nobody ever deploys cultural selection arguments against a failed trend that everyone hates. Nobody ever says “throughout history, most societies haven’t made people marry rocks, so we shouldn’t force people to marry rocks now”. Nobody wants to marry rocks now, so nobody needs to argue against it! Cultural selection arguments only get deployed against things that were once unpopular, but are in the process of becoming more popular - ie alleles that are currently being selected for! This isn’t necessarily hypocritical. You could say that certain institutions are spreading for good reasons, and others are spreading for bad ones (and TGGP links my Competing Selectors post which makes exactly this point). But now you’re not really making a cultural selection argument, you’re making an “I did some armchair reasoning and decided this was bad” argument. I think TGGP would answer that it doesn’t require any selective pressure to explain why people would want to have more romantic partners, since this is inherently fun for everyone. But first of all, no it isn’t - you can read the responses to this thread to see how viscerally unhappy some people are about this. And second of all, however fun it is now, it was probably equally fun a hundred years ago, so we still need an explanation for why it’s happening now and not earlier. Another possible argument is that polyamory isn’t spreading by monogamous cultures dying out and being replaced by polyamorous ones. It’s spreading by word of mouth. But this is also how almost every cultural trend spreads. Monogamy didn’t spread to Scandinavia because the Vikings died out and the Romans colonized their land, it spread because missionaries converted them to Christianity. If some memoir converts somebody to polyamory, that seems like the closest modern-day equivalent. I don’t really know how to rescue cultural selection arguments from these kinds of considerations. Ascend writes: Okay, I have two basic objections to polyamory. The first is a broader but weaker point, and the second is narrower and stronger. 1. If you actually love someone, that person should be enough for you. Especially, if most people who claim to love someone do, in fact, find that that person is enough for them. I struggle to see how it doesn't almost follow by definition that if Aaron wants to be in a monogamous relationship with Brenda, and Carl wants to be in a polyamorous relationship with Diana, then Carl loves Diana less than Aaron loves Brenda. Now maybe this assumption can be refuted somehow, by reference to irreducible personality types or something, but it certainly seems like the prima facie assumption, and requires an affirmative defence. Splitting this up into two paragraphs so I can answer one at a time. The traditional response is to ask: Do you think it’s bad for someone to have a second child? Surely if they really love their first child, one should be enough for them! More than one friend? In fact, why do they need to have a friend at all? Shouldn’t their partner be enough? I think you can think of this in one of two ways. One is to imagine the original objection in the mouth of a Dickens villain: “We can’t invite other people to our Christmas party! They would consume our limited supply of Christmas cheer, and then there wouldn’t be enough left for us!” Obviously at the end of the Dickens book, the character discovers that cheer isn’t a limited resource, and multiplies rather than divides when shared with others. Some people genuinely think this way. This isn’t really how things work for me. I want my wife to definitely be the most important person in my life and vice versa. But I find I can carve out a category “secondary partner” that doesn’t interfere with this, any more than her having friends , hobbies, children, etc interferes with this. Probably other people’s psychology doesn’t work this way, and those people wouldn’t enjoy being poly. 2. There seem to be two types of polyamory: the "hippie" kind where a group of people are all in a single demarcated "relationship" with each other, all know each other as either friends or lovers, and having sex with anyone outside that group would be condemned as cheating. And the "open relationship" kind where two people are dating or married but are "free" to sleep with other people (but still have each other as a "primary partner" or some such). The first, while I'm not endorsing it, seems to have decent case for being a form of actual love. The second, unless I'm missing something, looks like despicable pure hedonism. First, because the "primary" aspect shows it really is all about sex, not about sharing your love with someone else. Second, because it's basically legitimised cheating, and for all the talk of mutality what's to stop someone pressuring their spouse to "consent" to "opening" their relationship? (I've seen a number of online stories of this happening, though with beautiful poetic justice where the pressured partner ends up finding someone who actually values him or her and wants a true relationship, and the other partner ending up entirely alone and certainly not finding the harem they were expecting). And third, because it creates *competition* between the two spouses over who can get more partners, and for fuck's sake a marriage is the ONE place such toxic sexual competition should not exist! Re: 2 - As I mentioned above, polyamory seems more about the romance angle than the sex angle. One interesting demonstration of this is how many asexual people are poly. In the 2017 SSC survey (the same one cited above), about 5% of polyamorous people described themselves as asexual (having no sex drive) compared to about 3% of monogamous people. These people are probably in relationships for the emotional benefits. I also checked sex drive among people who were in monogamous relationships, stable polycules, and open relationships (this is the 2019 SSC survey, which went into more depth on sex and romance). There were no significant differences in sex drive among these three categories. Piotr Pachota (blog) writes: Invectives about polyamory are inevitable now, in the current phase of polyamory Overton window shift. This is the only acceptable way polyamory can be currently portrayed and discussed. As Overton windows move for new social norms like LGBT and polyamory, the mainstream media narratives evolve along the axis of omission/taboo -> negative/critique -> ambiguity -> struggle/oppression ->positive -> new normal. We have seen LBGT cover almost all these steps during recent 40 years, currently I think we are between positive and new normal. With polyamory, we have just recently moved from omission/taboo to negative/critique. Portraying polyamory as positive or struggling/oppressed in mainstream media is still out of the Overton window, showing ambiguity is now at the edge, only negative critique is in the window. This is also why almost all movies and shows about polyamory are telling a story of a failure of a polyamorous relationship. Positive polyamory testimonials exist on social media, but usually the comments below are a shitstorm. This also proves how positive portrayal is unacceptable. At the same time, positive polyamory testimonial + shitstorm comments = negative meta-content bundle that itself fits well within the Overton window. Note that these negative portrayals still promote polyamory somehow, as they at least put it on the map. 10 years ago there were no polyamory movies, shows or social media content - it would have been unthinkable, as we were in the omission/taboo phase back then. Yeah, one pattern I see pretty often goes something like: Weird people, who maybe weren’t able to cope with normal institutions, find some weird new thing that works for them, okay, cool, whatever.
Inline links: https://substackcdn.com/image/fetch/$s_!iguW!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F75d2b2f1-9498-45aa-9078-4e660adc0c04_384x278.webp, https://substackcdn.com/image/fetch/$s_!oTZp!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F1bd7971a-e7f2-4074-9bf9-54db5c080ca8_393x279.webp, https://substackcdn.com/image/fetch/$s_!sPmI!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F0d7da863-d181-456f-82a5-e52b2b441ee7_429x278.webp, https://substackcdn.com/image/fetch/$s_!Sbhb!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F5781e942-794a-48c6-81cc-f2b7db4e2498_386x278.webp, https://substackcdn.com/image/fetch/$s_!H1JY!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F1c6d2850-129b-4063-96f2-132d3ce479c6_389x278.webp, https://substackcdn.com/image/fetch/$s_!IQDj!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fbcbe1638-bb73-41bc-90fd-f19832dc4108_400x278.webp, blog, writes, writes, the canonical poly survey, Commenters agreed with this, blog, writes, https://substackcdn.com/image/fetch/$s_!G7xC!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fa47bcb0c-e3ef-4897-9ee5-f8404ea227c3_810x805.png, writes, Competing Selectors, writes, Some people genuinely think this way, blog, writes
polysemanticity2 mentions across 2 issues

polysemanticity is a recurring concept in the Astral Codex Ten archive, appearing 2 times across 2 issues between November 27, 2023 and March 07, 2025. The archive places it in contexts such as ""The authors described this as 'polysemanticity' - multiple meanings for one neuron""; "The best real answer I can come up with is polysemanticity and superposition". It most often appears alongside An Introduction To Circuits, Anthropic, Anthropic interpretability team.

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polysemanticity
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2
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2
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November 27, 2023
Last seen
March 07, 2025
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God Help Us, Let's Try To Understand AI Monosemanticity
November 27, 2023 · Original source
Second, this doesn’t work. When you switch to a weaker AI with “only” a few hundred neurons and build special tools to automate the stimulus/analysis process, the neurons aren’t this simple. A few low-level ones respond to basic features (like curves in an image). But deep in the middle, where the real thought has to be happening, there’s nothing representing “dog”. Instead, the neurons are much weirder than this. In one image model, an earlier paper found “one neuron that responds to cat faces, fronts of cars, and cat legs”. The authors described this as “polysemanticity” - multiple meanings for one neuron.
Inline links: earlier paper
Why Should Intelligence Be Related To Neuron Count?
March 07, 2025 · Original source
The best real answer I can come up with is polysemanticity and superposition. Everyone has more concepts they want stored than neurons to store them, so they cram multiple concepts into the same neuron through a complicated algorithm that involves some loss of . . . fidelity? Usability? Precision? If you have too few neurons, the neurons have to become massively polysemantic, and it becomes harder to do anything in particular with them.
Inline links: polysemanticity and superposition
more neurons in the brain -> there are more possible configurations of firing -> it's a "richer" language. one consequence of this is that you need less polysemanticity, as you said.
pop art2 mentions across 2 issues

pop art is a recurring concept in the Astral Codex Ten archive, appearing 2 times across 2 issues between December 04, 2024 and January 08, 2025. The archive places it in contexts such as "Wolfe ties this to the contemporaneous rise of pop art"; "In art and architecture, the drive to be “in touch” took the form of pop art". It most often appears alongside Edward Stone, Frank Lloyd Wright, From Bauhaus To Our House.

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pop art
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2
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2
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December 04, 2024
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January 08, 2025
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Book Review: From Bauhaus To Our House
December 04, 2024 · Original source
Wolfe ties this to the contemporaneous rise of pop art. Modern art and architecture were founded in the rejection of bourgeois notions of beauty, in favor of a faux-proletarian idea of simplicity and scientificness. But, Venturi pointed out, proletarians were kind hard to find in c. 1970 America. Grounding your class analysis in a non-existent proletariat seemed kind of out-of-touch, and so - perhaps - bourgeois. Who actually existed? The middle class. And what did the middle class like? Mass market consumer slop. Therefore, the true foundation of Art should be mass market consumer slop. Of course, since artists are superior to the middle class, it should be some sort of extremely complicated reference to mass market consumer slop which makes it clear that the artist themselves is infinitely above such things (but also, what if they weren’t above it, because they were so in-touch with normal people (but also, obviously they’re infinitely above it (but also, what if they weren’t))) . . . and so on. This tendency eventually became postmodernism with all its layers of irony and self-reference.
On Priesthoods
January 08, 2025 · Original source
In art and architecture, the drive to be “in touch” took the form of pop art and postmodern architecture, where artists took the materials of normal public life (like Cambpell’s soup cans) and transformed it in some kind of complicated way. The average member of the public might think “Campbell soup! That artist is in touch with my everyday existence!” while also being baffled by layers of ironic reference and artistic flourishes outside his puny little brain’s ability to comprehend. A+ instant classic.
populism2 mentions across 2 issues

populism is a recurring concept in the Astral Codex Ten archive, appearing 2 times across 2 issues between January 29, 2021 and August 05, 2025. The archive places it in contexts such as "a response to populism"; "" strong Gods " of populism, nationalism, and religion". It most often appears alongside 80,000 Hours, AI alignment problem, Amish.

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populism
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2
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2
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January 29, 2021
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August 05, 2025
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Contra Weyl On Technocracy
January 29, 2021 · Original source
I find Axes 1, 3, 4, and 5 kind of boring once we take the time to decompose them. Everybody's already argued the merits of government intervention vs. libertarianism, of populism vs. elitism, etc. Weyl seems to have a special interest in Axis 2 - mechanism vs. human judgment - and I think this is the most interesting potential point of disagreement.
I worry that Weyl is kind of cargo-culting a response to populism, a sort of "The masses hate science and reason and improving things, right? So maybe if we never do any of that stuff then they'll let us live". This hasn't been my experience of the masses. My experience has been they hate elites trying to lecture them on what to do, especially if justified in pseudoscientific mumbo-jumbo that they can see through easily.
Should Strong Gods Bet On GDP?
August 05, 2025 · Original source
According to R. R. Reno, editor of the magazine First Things, the liberal project of the past three generations has sought to weaken the “strong Gods” of populism, nationalism, and religion that were held to be the drivers of the bloody conflicts of the early 20th century. Those gods are now returning, and are present in the politics of both the progressive left and far right—particularly the right, which is characterized today by demands for strong national identities or religious foundations for national communities.
Inline links: strong Gods
POSIWID2 mentions across 2 issues

POSIWID is a recurring concept in the Astral Codex Ten archive, appearing 2 times across 2 issues between April 15, 2025 and July 01, 2025. The archive places it in contexts such as "…in real life POSIWID is mostly used to push people from the Balanced to the Paranoid perspective"; "POSIWID (or its inverse) adds nothing except an attempt to ban this excellent and communicative expressive technology"; "Without POSIWID, people could think about all of these possibilities and come to their own conclusions. POSIWID tries to ban thinking about 1-5 by fiat". It most often appears alongside America, China, FDA.

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POSIWID
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2
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April 15, 2025
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July 01, 2025
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Highlights From The Comments On POSIWID
April 15, 2025 · Original source
Balanced: Systems can fail for many reasons. Sometimes it’s just a hard problem with tradeoffs. Sometimes it’s been perverted from its original goal by special interests. Sometimes it’s some third thing. Usually it’s a combination of all of these. You can’t know for sure until you look at it closely. …then I think the people who use the phrase want to imagine that they’re pushing people from Naive to Balanced. But I think the last person to hold the Naive perspective died sometime in the 1980s, and in real life POSIWID is mostly used to push people from the Balanced to the Paranoid perspective without actually looking at the system involved or arguing the case. And second, the explanation above is just the most popular of about a half-dozen different exegeses that commenters offered. So if you do want to communicate the thing I suggested above - which, reminder, is: If a system consistently fails at its stated purpose, but people don’t change it, consider that the stated purpose is less important than some actual, hidden purpose, at which it is succeeding …I think you should just say that, instead of the confusing version that half of your audience will misinterpret, and which incorrectly implies that this always happens. When people insist on the confusing and inappropriately-strong version, I start to suspect that the confusingness is a feature, letting them smuggle in connotations that people would otherwise correctly challenge. Hopefully this will become clearer as I answer your comments one by one, starting with: Charles Lehman writes (X): The actually useful insight from POSIWID is the negative corollary: there is "no point in claiming that the purpose of a system is to do what it constantly fails to do." This was the original, less-catchy form, but it seems exactly the same to me, and equally wrong. For example, Iran’s intelligence agency consistently fails to prevent Israel from infiltrating and attacking their nuclear program. But it’s very useful to claim that their purpose is to prevent this! If we both try to predict the behavior of Iranian intelligence, and I’m allowed to use the hypothesis “their purpose is preventing Israeli infiltration”, and you’re not allowed to use that hypothesis, I will consistently outpredict you. For example, I’ll be expecting them to interview security staff to see which ones are Israeli spies, try to intercept Israeli communications, and do other espionage activities, and you’ll still be stuck wondering whether they might take up gardening or ballet dancing. The clear, natural language expression of this useful hypothesis is “the purpose of Iran’s intelligence forces is to prevent Israeli infiltration, but they usually fail”. This clear, natural language expression is great and tells you everything that you need to know. POSIWID (or its inverse) adds nothing except an attempt to ban this excellent and communicative expressive technology, in favor of some other vague meaning of “purpose” which can’t hang together and which nobody can really explain. Ersatz writes: “I thought the meaning was more something like “the system took these side effects into account and still considered that what it was doing was net positive in expectation, so the side effects are as much part of the system's purpose as the ‘positive’ outcomes”. This is just diluting the word “purpose” into incoherence. I think it’s useful linguistic technology to be able to say “The New York bus system both transports people from place to place, and emits lots of carbon dioxide. Its purpose is the transportation, and the carbon dioxide is an unfortunate side effect”. If the goal of POSIWID is to insist that no, the transportation and the CO2 emissions are equally purposeful, or that we’re not allowed to talk about that question, then it sabotages our ability to communicate clearly, for no apparent gain. Consider the New York carbon dioxide system, a hypothetical government department dedicated to emitting as much carbon dioxide as possible (why? to own the libs, of course!) Sometimes people drive motorcycles along its vast network of CO2 pipes, allowing them to travel from place to place. Is this exactly the same as the New York bus system? No? Why not? A natural answer would be “Because the bus system is aimed at transportation, but emits some CO2 as a minor side effect, and the CO2 system is aimed at emission, but facilitates transport as a minor side effect.” If your objection is going to be that instead of considering purpose, you should restrict yourself to saying that one transports more people than it emits CO2, and the other emits more CO2 than it helps transport people, you’ve now legislated that we must list exactly how many people the New York bus system transports, and how much carbon dioxide it emits, and how many ants it crushes, etc, every time we talk about it. But most people who talk about the bus system don’t know these statistics, and don’t have to. It’s sufficient (and linguistically convenient) to say “Its purpose is transportation, not CO2 emission or ant-crushing. Andrew Pearson writes: The steelman of the phrase, which might be what Stafford Beer had in mind when he coined the phrase, is that in large complex organisations it's very hard for individual workers to see a link between what they do and the stated purpose of the organisation - people just get on and do what they're told, and orient themselves more towards "doing what they're already doing, just more effectively" than towards "fulfilling the stated purpose of the organisation". I don’t think this is a great steelman. True, the average employee’s actions don’t obviously connect to the organization’s stated purpose. But the average employee’s actions also don’t obviously connect to what the organization does. If the stated purpose of the US military is to protect America, and what it does is bomb Middle Eastern weddings, both of those are equally remote from the day-to-day life of some low-level employee who just counts the number of screws in a warehouse. Aashish Reddy writes: I think POSIWID is best applied to bureaucracies or large structures where the reason bad outcomes occur is not because of difficult battles with reality (like government or hospitals or the Ukrainian military), but because of the way incentives are set up in the system. If someone said, “the purpose of the Civil Service is to drive through new, innovative ways of delivering rapid change!”, that would clearly be absurd. That may be their goal, or how they see themselves; but the purpose of the system is not defined by either of those things. If it was, they wouldn’t incentivise caution and slowness. Whether that’s good or not, the purpose of the Civil Service is best approximated by what it does! I want to pay more attention to the word “goal” in the second sentence of the second paragraph: “[Driving innovative change] may be their goal, or how they see themselves.” It sounds like Aashish think it’s useful to use the word “goal” to discuss what a system is trying to do, separately from what it does or doesn’t accomplish. I agree! I just think “purpose” is a synonym for goal. If you use POSIWID, you have to posit some kind of weird new ontology where “purpose” means the opposite of “goal”. If you don’t use POSIWID, you can just keep the words “purpose” and “goal” having their regular everyday meaning, and describe this state of affairs with phrases like “The goal/purpose of the Civil Service is to deliver rapid change, but due to perverse incentives, its actual effect is to prevent change.” Kay writes: For example, the US policing and criminal justice system and prisons seem to continually over imprisons people in general, and especially people of colour. These systems seem not to be changed, while they ostensibly truly could be. So to me this seems that the system may be working "to purpose" for the actors who want it to work that way. This is interesting because Kay is using a left-wing example: “The criminal justice system imprisons too many people of color, so its purpose is to oppress black people”. But one of the tweets in my original post was close to its right-wing opposite: “The criminal justice system consistently lets criminals off with a slap on the wrist, so its purpose is to get people raped and murdered.” As long as people are thinking in these terms, they’re going to be prey for whichever conspiracy theory best suits their pre-existing prejudices. I think both of these are worse than the Balanced View version: Some people care a lot about keeping people safe from crime, but other people care a lot about the human rights of suspects and convicts. The incarceration rate is a balance between these two forces, with some lesser contribution from sinister forces like private prison owners who want to increase incarceration to line their pockets. This has the advantage of being obviously true (there are pro-tough-on-crime activist groups and pro-soft-on-crime activist groups, they both do effective activism for their chosen cause, and the exact incarceration rate depends on which ones are in the ascendant and have the ear of politicians), and not being a conspiracy theory that forces you to believe that the government is a monolithic entity that really wants people to be raped and murdered. NegatingSilence writes: Come on, obviously "The Purpose of a System is What it Does" is meant to draw your attention to the incentives in cases where something different is happening than is supposed to be happening. My government purposefully raised housing prices for the benefit of people who own assets. They talk about "trying" to make things more affordable, but somehow they only succeeded in raising the cost by 500% in nominal terms. What a curious result. I don’t know what country this person is in. But in my country, housing prices are high because of a combination of all of the following: Citizens want to preserve “neighborhood character”: they currently live in a low-density low-crime low-traffic pretty suburb, they want it to remain a low-density low-crime low-traffic pretty suburb, and they worry that building new homes threatens that status.
Inline links: writes (X), writes, writes, writes, writes
Biden supports Xi’s campaign to prevent Chinese people from getting addicted to video games, and wants to keep video-game-enabling GPUs out of the country. …and design experiments to distinguish between these, or wait for more chip sanctions to see how they pan out. But in real life, we can be very sure some of these (like 2 and 7) weren’t intended, and others (like 4) were. Why? Some combination of trusting Biden’s stated goals, psychoanalyzing Biden’s plausible goals, checking who lobbied Biden to do this, and reading enough international relations journals to get a sense of what policymakers are thinking about. I think it’s fine to do black box systems analysis, just like it’s fine to do behaviorism. But we should view these as methodological commitments for a specific group, rather than good strategies for normal people. Jared Peterson (blog) writes: This originally struck me as rather silly and as an obvious misinterpretation of an idea that has nothing to do with human intentions...then I read the comments and saw many people claiming exactly that! Donella Meadows is an important figure in the field of Systems Thinking, and says by definition (whether human designed or not), systems have a purpose. "A system’s function or purpose is not necessarily spoken, written, or expressed explicitly, except through the operation of the system. The best way to deduce the system’s purpose is to watch for a while to see how the system behaves. Purposes are deduced from behavior, not from rhetoric or stated goals” One way to think about this is that Meadows would be OK talking about Molochs purpose as something coherent. Is changing the climate the purpose of modern capitalism? In one sense, no. But simultaneously, it is perfectly coherent to talk about the system as having that exact purpose because the system seems to work towards that goal. Even if you push against the system, the system seems to adapt and continue with that goal anyways. There is something almost intelligent about systems where they seem to work towards goals that no one ever intended. But the phrase isn't about human goals at all! Oh! I agree this makes sense if you need to talk about the “purpose” of an un-designed system with no humans in it. Moonshadow writes: This sentiment is grasping towards the same sort of place as your "Meditations on Moloch" essay. No-one involved in the system wants what the system actually ends up doing. But whatever their individual intents, /the system as a whole/, if allowed to grow naturally, inevitably ends up doing what Moloch wants. Of course the purpose we intended for the system isn't really that, any more than Moloch really exists. But you can't begin the meta level fight - of designing the system's high level organisational structures and incentives to try to reduce this effect, instead of letting it emerge organically like it always does - unless you first admit the problem. I agree this is a useful thing to talk about, I just don’t think “purpose” is the right word for it. I’m not even sure “system” is the right word for it. A good example of Moloch would be two countries having a nuclear arms race. But how is this POSIWID? The purpose of the . . . system of two countries . . . is to . . . have a nuclear arms race? This is pretty different from how I usually hear it used. But here is a dissenting voice. Ajb writes: POSIWID was not originally an antagonistic political snark. It's perfectly sensible to notice that a system may be fulfilling other purposes than it does officially, and this is not incompatible with it operating in good faith. You can think of it as a bit like Chesterton's fence: * to reform a system you should understand what purposes it fulfills, not just what it is officially supposed to do * These additonal or alternative purposes may in fact be desirable ones that you should avoid breaking. Cybernetics (where the phrase originated) drew a lot of inspiration from biology, and there obviously nothing has an 'official purpose' at all. But it nevertheless has organisation and is functional. Rob writes: The problem with quoting aphorisms like this is that it misses the context - specifically the context of a management consultant (viz. Stafford Beer) who spends his entire life being told about systems his clients have put in place, with some stated purpose in mind. Those systems do not achieve their stated purposes, but can be continually defended against change by re-stating the purpose - this shouldn't work, but in practice it often does, because most people aren't great at decoupling intent from outcome. "The purpose of a system is what it does" is a good rhetorical counter, because it acknowledges that, in practice, any continuation of a system with known outcomes is a tacit acceptance of those outcomes as the system's real purpose. You don't get to claim some other "real" purpose once you know what the outcomes are. My interpretation has always been in the spirit of this tweet: https://x.com/primawesome/status/1178671690261286918?lang=en > My neighbor told me coyotes keep eating his outdoor cats so I asked how many cats he has and he said he just goes to the shelter and gets a new cat afterwards so I said it sounds like he’s just feeding shelter cats to coyotes and then his daughter started crying. I agree this makes more sense in the context of some supposed person claiming that “the system has good intentions” means they should never have to change the system. I don’t think I really see this failure mode. I bet a lot of you are going to yell at me and say that, I don’t know, homelessness or something is like this. But defenders of the current homelessness system never say you can’t change it because it had good intentions when it started. I predict they would say that their own group is doing good work, and it’s everyone else who needs to change. Or that the current system works a little and just needs to be funded more. Or that the current system is better than nothing, and your proposed attempt to “change” it is secretly a plan to gut it and leave homeless people without help. I definitely don’t think they’d say “Yes, your proposed change would improve the system, but you’re not allowed to make it because the people who designed the current system had good intentions”. Leah Libresco Sargeant writes: I think the Catholic principle of double effect is helpful here. This often comes up in the case of eg delivering a baby pre-viability because the mom has an infection that will progress to sepsis and death if she and the baby aren’t separated. The three criteria are: the nature of the act is itself good, or at least morally neutral;
Inline links: blog, writes, https://substackcdn.com/image/fetch/$s_!Dy01!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F6929f8eb-51df-403a-8666-268f9f1f034f_529x185.png, writes, writes, https://x.com/primawesome/status/1178671690261286918?lang=en, writes
Homeowners want to preserve or increase the value of their houses. Of these, I think 6 is one of the less important ones - if this were the dominating factor, people would support upzoning, since it usually raises the value of properties in the upzone (if developers can build skyscrapers on your land, then your land value goes up relative to the profitability of skyscrapers). But part of the problem is that people don’t support upzoning. So 6 can’t be the dominating factor. Without POSIWID, people could think about all of these possibilities and come to their own conclusions. POSIWID tries to ban thinking about 1-5 by fiat, insisting that 6 is the only possible explanation and anyone considering the others is naive. I think this makes it a bad heuristic. But there are two more concerning things about how Negating is using POSIWID. First, he’s picking out one particularly salient thing the system does (raise house prices) and claim that’s “the” purpose. He could equally well pick any of the other results - preserve neighborhood character, protect the environment, help Chinese people escape currency controls. Like I said in the original post, in practice POSIWID serves as justification for paranoia - whatever effect you like least, whatever possibility would be most sinister - that’s the one that the system is intentionally aiming for. Second, he’s saying it’s the purpose of “the” system. Which system? I bet whatever government he’s talking about has some organization called the Affordable Housing Bureau, or whatever. And I bet that the Affordable Housing Bureau really does make housing slightly more affordable, relative to the counterfactual where it doesn’t exist. It’s just that lots of other government, market, and social forces conspire to make it much less affordable. If Negating were to claim “The purpose of the Affordable Housing Bureau is to make housing less affordable”, this would be false even if the overall picture (the government is deliberately raising real estate prices) were true. Brad writes: I have to toss in Pournelle's Iron Law. The purpose of a system - when it is first established - may be dramatically different from the purpose it assumes after a few years. Consider: You establish a system to solve a problem. That could be homelessness, or asylum, or drug abuse, or any of a number of other things. This system employs people, who then have an automatic interest - not in solving the problem - but in prolonging it, even in making it worse. After all, without the problem, the organization would not need to exist. And hwold writes: I see it used as "if you have a complex system/bureaucracy to solve X, then the incentives inside it is for X to get worse, and incentives will not have 0 influence on outcomes" For example : https://x.com/Devon_Eriksen_/status/1906042672499864034 I think this sounds profound on first glance, and it’s probably true in some cases. But it’s not nearly true enough to be an Iron Law. Try to think about it in specific Near Mode cases: If you eliminated police, would crime go down, because the police have an incentive to preserve crime? If you eliminated the fire department, would fires go down, because the fire department has an incentive to preserve fire? If you eliminated doctors, would cancer deaths go down, because doctors have an incentive to preserve cancer deaths? If you eliminated the FDA, would dangerous drug side effects go down, because the FDA has an incentive to preserve dangerous drug side effects? If you eliminated the Federal Reserve, would bank runs go down, because the Federal Reserve has an incentive to preserve bank runs? Brad’s original comment mentions homelessness and drug abuse, but I know some drug abuse doctors, and they’re (mostly) good people who do their best in a tough situation. Drug abuse doesn’t continue because drug abuse doctors are secretly ensuring it continues to help their bottom line. Drug abuse continues because fentanyl is really, really addictive. Even good conspiracy theories don’t work like this. Was there a conspiracy among pain pill manufacturers to addict people? Yeah, kinda, although I think the degree to which this caused the opioid crisis is pretty overblown. But the pain pill manufacturers weren’t a system dedicated to preventing addiction. They did their job (reduce pain) fine, then ran an unrelated evil conspiracy on the side! Breb writes: This way of thinking may result from taking a strategy for predicting the motives of individuals, and using it to predict the motives of organisations. "Cui bono?" works when you're considering a single action carried out by a single person at a single moment in time, but it doesn't really work when you're considering the behaviour of hundreds of people who are incentivised to somewhat-but-not-perfectly cooperate over a long period to somewhat-but-not-perfectly implement a goal that was established by someone who somewhat-but-not-perfectly understands that that goal is just an instrument to attain a larger, more complex goal set by somebody else. I’m against this for individuals too! There are a million self-help gurus who try to convince you that that if you procrastinate - let’s say you always do term papers the night before and get terrible grades and it’s threatening your ability to complete college - then it must be because this secretly benefits you in some way. Maybe your overly-strict father wants you to complete college, and you’re deliberately trying to fail as a secret act of rebellion against him hidden even from yourself. Although something like this might sometimes be true, more often a clearer understanding of the circuitry involved (in this case, hyperbolic discounting) saves you from these labyrinths and lets you think about things straightforwardly again. Tom J writes: In the original Stafford Beer sense, the slogan POSIWID means that you can't tell from outside the system whether any given behaviour was *intended* or not. For the purposes of objective analysis, you have to treat your system as a black box that *does* whatever it's observed to do, as opposed to what people *claim* the point of the system is. This may be true in cybernetics. Or it may be an interesting methodological commitment, in the same way that the behaviorists’ “assume there is no such thing as human interiority” was an interesting methodological commitment. But I don’t think it’s common or valuable in normal-life analysis of social systems. When Biden bans NVIDIA from sending advanced chips to China, black box analysis would have to be ambivalent between explanations like: Biden personally hates Jensen Huang and wants his company to suffer
Inline links: writes, writes, https://x.com/Devon_Eriksen_/status/1906042672499864034, writes, hyperbolic discounting, writes
Links For July 2025
July 01, 2025 · Original source
44: People are still talking about POSIWID.
Inline links: People are still talking about POSIWID
postrationalists2 mentions across 2 issues

postrationalists is a recurring concept in the Astral Codex Ten archive, appearing 2 times across 2 issues between February 20, 2024 and February 20, 2025. The archive places it in contexts such as "there’s a group called the “postrationalists” who were vaguely inspired by rationalist writings"; "Pope Eliezer LXXVII to evangelize to the postrationalists". It most often appears alongside COVID, Elon Musk, 2024 presidential election.

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postrationalists
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24
February 20, 2024 · Original source
My current understanding of what happened: there’s a group called the “postrationalists” who were vaguely inspired by rationalist writings but also think the emphasis on facts is boring and autistic and we need to focus more on creativity/friendship/woo/intuition/vibes. They have a gathering called VibeCamp where they do artsy stuff. Someone from Manifold went to a theater production by a postrat group called “The Classics Department”, liked them, and hired them to make a promotional event for Manifold. They are sort of rationalists and prediction market junkies, but also sort of making fun of rationalists and prediction market junkies. Hence this show.
Inline links: VibeCamp, “The Classics Department”
Lives Of The Rationalist Saints
February 20, 2025 · Original source
St. Michael Beisotsukai was sent by Pope Eliezer LXXVII to evangelize to the postrationalists. When he arrived at TPOT, they fell upon him, taunting “If you are so rational, then predict the way we are going to kill you”, for however he predicted, they planned to kill him through some other method. But St. Michael gave a probability distribution across all common methods of execution that also left substantial probability mass on unknown unknowns, and followed it up with an eloquent lecture on out-of-model error. The postrationalists were so impressed that they converted on the spot and didn’t kill him at all - but this was fine, because St. Michael’s distribution had included a 10% chance that this would happen, and later evidence from other missionaries demonstrated this to be well-calibrated.
poverty2 mentions across 2 issues

poverty is a recurring concept in the Astral Codex Ten archive, appearing 2 times across 2 issues between November 28, 2023 and March 26, 2026. The archive places it in contexts such as "a lot of work on global health and poverty"; "Consider something human-level and common-sensical like poverty". It most often appears alongside #57, 80,000 Hours, Adam D’Angelo.

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poverty
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In Continued Defense Of Effective Altruism
November 28, 2023 · Original source
I don’t want the takeaway from this post to be “Sure, you may hate EA because it does a lot of work on AI - but come on, it also does a lot of work on global health and poverty!” I’m proud of all of it. I believe - just like Geoff Hinton, Bill Gates, Sam Altman, Daniel Dennett, etc - that there’s a pretty serious risk of human extinction from AI over the next few decades. I can’t imagine believing this and not thinking it’s important to prepare for. EA has done a great job working on this (see list of accomplishments above), and I think the AI and x-risk people have just as much to be proud of as the global health and animal welfare people.
Inline links: just like
Ethiopia source here and here, India source here, Rwanda source here.
Inline links: here, here, here, here
How Natural Tradeoff And Failure Components?
March 26, 2026 · Original source
Consider something human-level and common-sensical like poverty. People may be poor because of “failures” - negative qualities with no counterbalancing advantages. For example, they may be unintelligent, or chronically ill, or stuck in poor areas with bad education systems. These are cases where something goes wrong - their body, their health care system, their schools.
Pragmatism2 mentions across 2 issues

Pragmatism is a recurring concept in the Astral Codex Ten archive, appearing 2 times across 2 issues between September 15, 2023 and December 12, 2023. The archive places it in contexts such as "with specializations in Pragmatism and aesthetics"; "I think you’re doing pragmatism wrong". It most often appears alongside Bitcoin, Ethereum, 2024.

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Book Review Contest 2023 Winners
September 15, 2023 · Original source
The Rise And Fall Of The Third Reich, reviewed by J. J. spends his time writing stories and reading literary novels. He has a master's degree and three-quarters of a doctorate in philosophy, with specializations in Pragmatism and aesthetics.
Inline links: The Rise And Fall Of The Third Reich
Son Of Bride Of Bay Area House Party
December 12, 2023 · Original source
“I think you’re doing pragmatism wrong. That’s not how it’s supposed to work.”
“If I was doing pragmatism wrong, then I would have to switch to doing it right. And by your supposition, then I would have to believe in the Israel-Palestine conflict. And that would make me less religious, which would be bad for society. So from a pragmatic point of view, I’m doing pragmatism exactly right, no matter what the philosophers say.”
prefrontal cortex2 mentions across 2 issues

prefrontal cortex is a recurring concept in the Astral Codex Ten archive, appearing 2 times across 2 issues between June 10, 2022 and September 30, 2022. The archive places it in contexts such as "maybe the prefrontal cortex ? which is only online part of the time"; "perhaps also the prefrontal cortex". It most often appears alongside Scott, 4chan, 5HT2A serotonin.

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Somewhat Contra Marcus On AI Scaling
June 10, 2022 · Original source
DALL-E, “A elderly person's hand, labelled with the text ‘AN ELDERLY PERSON'S HAND’” Lucid dreaming enthusiasts suggest that two of the easiest ways to distinguish dreams from reality is that, in dreams, hands have the wrong number of fingers, and text is garbled and unreadable. This is not a coincidence because nothing is ever a coincidence. But even the waking world gives us clues, as Sarah Constantin notes in Humans Who Are Not Concentrating Are Not General Intelligences. Most adults will make GPT-like mistakes (or gloss over such mistakes) unless they’re focusing all their brainpower on an issue. And a 4chan post by someone who claims to have done psych research in prison populations goes further (slightly edited for language and offensiveness): I did IQ research as a grad student, and it involved a lot of this stuff. Did you know that most people (95% with less than 90 IQ) can't understand conditional hypotheticals? For example, "How would you have felt yesterday evening if you hadn't eaten breakfast or lunch?" "What do you mean? I did eat breakfast and lunch." "Yes, but if you had not, how would you have felt?" "Why are you saying that I didn't eat breakfast? I just told you that did." "Imagine that you hadn't eaten it, though. How would you have felt?" "I don't understand the question." It's really fascinating [...] Other interesting phenomenon around IQ involves recursion. For example: "Write a story with two named characters, each of whom have at least one line of dialogue." Most literate people can manage this, especially once you give them an example. "Write a story with two named characters, each of whom have at least one line of dialogue. In this story, one of the characters must be describing a story with at least two named characters, each of whom have at least one line of dialogue." If you have less than 90 IQ, this second exercise is basically completely impossible. Add a third level ('frame') to the story, and even IQ 100's start to get mixed up with the names and who's talking. Turns out Scheherazade was an IQ test! Time is practically impossible to understand for sub 80s. They exist only in the present, can barely reflect on the past and can't plan for the future at all. Sub 90s struggle with anachronism too. For example, I remember the 80-85s stumbling on logic problems that involved common sense anachronism stuff. For instance: "Why do you think that military strategists in WWII didn't use laptop computers to help develop their strategies?" "I guess they didn't want to get hacked by Nazis". Admittedly you could argue that this is a history knowledge question, not quite a logic sequencing question, but you get the idea. Sequencing is super hard for them to track, but most 100+ have no problem with it, although I imagine that a movie like Memento strains them a little. Recursion was definitely the killer though. Recursive thinking and recursive knowledge seems genuinely hard for people of even average intelligence. I have no proof that this person is who they say they are, but it matches some of my experience giving cognitive exams to patients from low-functioning populations. And it matches Flynn on Luria (who admittedly was approaching IQ from a cultural relativist viewpoint, but one which I think is equally applicable to the current problem). Luria gave IQ-test-like questions to various people across the USSR. He ran into trouble when he got to Uzbek peasants (transcribed, with some changes for clarity, from here): Luria: All bears are white where there is always snow. In Novaya Zemlya there is always snow. What color are the bears there? Peasant: I have seen only black bears and I do not talk of what I have not seen. Luria: What what do my words imply? Peasant: If a person has not been there he can not say anything on the basis of words. If a man was 60 or 80 and had seen a white bear there and told me about it, he could be believed. And: Luria: There are no camels in Germany; the city of B is in Germany; are there camels there or not? Peasant: I don't know, I have never seen German villages. If is a large city, there should be camels there. Luria: But what if there aren't any in all of Germany? Peasant: If B is a village, there is probably no room for camels. And: Luria: What do a chicken and a dog have in common? Peasant: They are not alike. A chicken has two legs, a dog has four. A chicken has wings but a dog doesn't. A dog has big ears and a chicken's are small. Luria: Is there one word you could use for them both? Peasant: No, of course not. Luria: Would the word "animal" fit? Peasant: Yes. And: Luria: What do a fish and a crow have in common? Peasant: A fish — it lives in water. A crow flies. If the fish just lies on top of the water, the crow could peck at it. A crow can eat a fish but a fish can't eat a crow. Luria: Could you use one word for them both? Peasant: If you call them "animals", that wouldn't be right. A fish isn't an animal and a crow isn't either. A crow can eat a fish but a fish can't eat a bird. A person can eat fish but not a crow. What I gather from all of this is that the human mind doesn’t start with some kind of crystalline beautiful ability to solve what seem like trivial and obvious logical reasoning problems. It starts with weaker, lower-level abilities. Then, if you live in a culture that has a strong tradition of abstract thought, and you’re old enough/smart enough/awake enough/concentrating enough to fully absorb and deploy that tradition, then you become good at abstract thought and you can do logical reasoning problems successfully. (Sometimes! If you’re lucky! Linda is a blah blah blah you know the story. Is she more likely to be a bank teller, or a feminist bank teller. When people get this question wrong, do they have a world-model, or not?) Imagine a world where doctors gave different diagnoses based on unrelated contingent features of the encounter like a patient’s gender, their race, or how you phrase the question. What a crazy place that would be! What is the pre-logical function that logic gets knit out of? I think it’s something like predictive pattern-matching. I think the brain starts by predicting arbitrary patterns, builds up more and more layers of abstraction to try to predict those patterns better, and eventually some of those layers cohere into something that looks like formal logic. To put it another way, my brain is in some sense a supercomputer that can outperform the best calculating machines in the world - but also, I have trouble multiplying three digit numbers in my head. The supercomputer is doing something, and then I’m using that something, very lossily, to emulate logical functions like math or formal logic. So when I see GPT, which also runs on a supercomputer, also slowly gaining the ability to multiply two-digit, then three-digit numbers as the supercomputer gets bigger and bigger, I feel a sort of kinship with it. It’s a trash heap of patterns with a hard-won ability to sometimes break out into the clear day of logical reasoning, just like me. IV. I think Marcus knows and agrees with most of this, but I think he thinks of the world-modeling ability as some special rare brain region (maybe the prefrontal cortex?) which is only online part of the time (or maybe can have its performance degrade gracefully). Whereas I think of it as shallower pattern-matching abilities which escalate to deeper and deeper pattern-matching abilities as more and more brainpower becomes available, with world-modeling as one of the deepest (and sure, probably the PFC plays a major role, but not because it has a fundamentally different structure but just because that’s where reinforcement learning stuck the highest-level patterns). Why do I think this? The human brain is pretty plastic. Usually if one part of it dies, another part can take over. This makes me think that the brain area : function correspondence isn’t entirely a function of different structures in different regions (though some of it might be this), but downstream of an originally poorly-differentiated blob of neurons that get trained by the overall predictive structure based on their proximity to various input ports (eg sensory nerves) output ports (eg motor nerves), and other brain areas. (this would also explain why the brain has a pretty consistent area dedicated to reading/writing, even though we haven’t been literate long enough to evolve new literacy-related structures) Deep learning agents are also a poorly-differentiated mass of neurons. As they get inputs and outputs (ie training data) they slowly “evolve”/develop the ability to “recognize” patterns. We don’t know how they do this or what recognition-abilities they’re evolving, except by speculating (the way Marcus and I are doing) based on what kinds of problems they can and can’t solve. It would make sense to me if poorly-differentiated blobs of neurons, when having lots of problems thrown at them, gradually move from developing simpler pattern-recognition programs (eg edge detectors), to more complicated pattern-recognition programs, all the way up to world-modeling, without any of these being hard-coded into the territory. (the brain does have a lot of things hard-coded - ie we’re not blank slates - but its plasticity suggests that the forms of hard-coding we’re talking about here are helpful but not completely necessary for cognition) If this were true, it would mean that as a blob of neurons got bigger, more sophisticated, and saw more training data, it would eventually develop new capabilities that weren’t hard-coded in, and that smaller versions of the same blob didn’t have. One of the really exciting things about GPT-3 was its sudden and unplanned development of new capabilities over GPT-2 (its creators mention “translation, question-answering, and cloze tasks, as well as several tasks that require on-the-fly reasoning or domain adaptation, such as unscrambling words, using a novel word in a sentence, or performing 3-digit arithmetic”). This seems like a good fit for the chimp → human transition, where evolutionary lineages that couldn’t do a bunch of difficult things for the first few hundred million years suddenly became good at those things in an evolutionary eyeblink. The ~5 million chimp/human gap seems like enough time to scale up chimp brains a bit (which definitely happened), but not enough time to invent a fundamentally new architecture. It wouldn’t surprise me if the architecture changed a little during this time, but we’re limited in how fundamental a change we can talk about over that period. I’m not at all sure this is true! I’m honestly close to 50-50 here. Maybe the PFC actually is magic! It just confuses me that Marcus seems to think we’ve ruled out the theory that this kind of scaling is possible, when I feel like we’ve heard plausible arguments on both sides. Nothing we’ve seen in GPTs or any other AI thus far disproves the scaling hypothesis, and a lot of what we’ve seen supports it. So sure, point out that large language models suck at reasoning today. I just don’t see how you can be so sure that they’re still going to suck tomorrow. Lemurs sucked for millions of years, then scaled up a bit and took over the world! V. …is one possible argument. Another possible argument is: language models and other deep learners really aren’t doing the same thing humans do - but whatever, their thing is powerful/effective/dangerous too. Suppose that GPT-X took over the world and killed all humans. Millennia later, some alien archaeologists come and investigate. They conclude that since its training data included Alexander the Great and Caesar, it was just pattern-matching to the kind of things they did (multiplied by a vector representing the difference between ancient and modern times), and GPT-X never demonstrated any true intelligence. So . . . what? I imagine this situation ALL THE TIME and I hate it. I think the impetus behind a lot of the AI risk stuff is that we’re barrelling to a world where AIs have far more than self-driving-car levels of capabilities, while being unpredictable in ways that are a lot like this. The history of the past few decades has been people getting surprised, again and again, at how much AIs can do without being “generally intelligent”. Douglas Hofstadter predicted in 1979 that any AI that could beat a grandmaster at chess would also be able to decide chess was boring and it preferred writing poetry. Instead, we got Deep Blue, so domain-specific it can’t even do so much as play checkers. Worse, now we have AIs that can switch between writing poetry and playing chess, and it still seems like a clever parlor trick rather than anything like real intelligence. I think basically nobody predicted this: narrow AI has won victories beyond past generations’ imagination. (cf. Nostalgebraist’s Human Psycholinguists: A Critical Appraisal) So even if GPTs aren’t a step on the path towards some sort of human-like AGI thing, I have no idea where they’ll end up. Replacing humans at all jobs? Writing novels? Taking over the world? If this seems crazy to you, “solve protein folding” sounded crazy ten years ago, and they already did that! At this point I will basically believe anything. VI. So I’m not going to take Marcus’ bet that GPT-4 will be perfect (as if anything ever is!). But here are some things I do believe, with confidence levels: At some point before 2030, someone will come out with a deep-learning-based language model which is significantly better than the current state of the art, by Gary Marcus’ admission (97%)
Inline links: hands have the wrong number of fingers, text is garbled and unreadable, Humans Who Are Not Concentrating Are Not General Intelligences, 4chan post, here, blah blah blah, https://twitter.com/GaryMarcus/status/1534887585759100930, a patient’s gender, their race, how you phrase the question, predictive pattern-matching, prefrontal cortex, mention, https://substackcdn.com/image/fetch/$s_!M9E6!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F85fd2e4d-c51e-4820-a9a2-6f79970026cb_600x368.png, https://substackcdn.com/image/fetch/$s_!_D9T!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F5cb652e3-381b-488d-a6a6-f1155f7ff557_586x194.png, writing poetry, playing chess, Human Psycholinguists: A Critical Appraisal
Highlights From The Comments On Unpredictable Reward
September 30, 2022 · Original source
One neuroscientific perspective on this is that in order for dopamine to track reward prediction *error* (RPE), it is logically necessary that some other piece of neural circuitry track reward prediction *per se*, often called "value." Those of us who think that dopamine is computing RPE on a moment-by-moment basis (the first derivative of value; see Kim, Malik et al., Cell, 2020) therefore generally also believe that some other part of the brain, especially the ventral striatum (aka nucleus accumbens) and perhaps also the prefrontal cortex, maintains an estimate of value that gets updated by dopamine. And indeed, there are dozens of papers reporting that neural firing in these brain regions correlate with value over and above RPE.
That said, it is also true that (1) NAc neurons correlate strongly with value and also respond to some extent to rewards, predicted and unpredicted; (2) cocaine or amphetamine in the NAc (and another region of the ventral striatum called the olfactory tubercle), which dramatically elevate dopamine levels, elicit robust responses; and (3) in the context of the "liking vs. wanting" framework you allude to, Kent Berridge and others have argued that the NAc contains a "hedonic hotspot", along with closely linked regions like the prefrontal cortex and ventral pallidum. This is an operational definition meaning that when you infuse opioid receptor agonists into said region, the animals react with pleasure, and conversely if you lesion/block activity in these areas, they don't show these behaviors as much, or even start showing defensive behaviors.
Prime Minister2 mentions across 2 issues

Prime Minister is a recurring concept in the Astral Codex Ten archive, appearing 2 times across 2 issues between December 09, 2022 and August 11, 2023. The archive places it in contexts such as "the new Prime Minister might be an Indian"; "His prime-minister is actually one of the most capable technocrat of his generation". It most often appears alongside Democrats, Republicans, US.

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Prime Minister
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Highlights From The Comments On Bobos In Paradise
December 09, 2022 · Original source
Britain is a good example; not because it's the most illustrative, but just because it's the only country with whose popular culture the average American might be expected to be somewhat familiar. And it's a similar story, old moneyed elite getting kicked down by a new and supposedly-more-meritocratic elite. The process was perhaps a bit slower and a bit less complete (e.g. the new Prime Minister might be an Indian but he still went to Winchester). Among the many trends explaining this, I don't think admissions at Oxford/Cambridge are really close to the top, nor even admissions at Eton etc.
Highlights From The Comments On Putin
August 11, 2023 · Original source
As someone, who left Russia less than a year ago, I agree. Gessen is a really talented journalist and writer, but boy is she biased. First of all, Putin is smart. For example, he is no economist, yet he's been able to choose qualified (and quite liberal) IFC-style people to run Ministry of Finance and the Central Bank. When several years ago local industrial lobby tried to criticize inflation targeting (and thus high interest rate) policy of the RCB, he came back with "look at what happens in Turkey". His prime-minister is actually one of the most capable technocrat of his generation. And the apparent incompetence of the military and secret services looks more of a feature (coup-proof) than a bug.
progressives2 mentions across 2 issues

progressives is a recurring concept in the Astral Codex Ten archive, appearing 2 times across 2 issues between February 20, 2023 and August 12, 2025. The archive places it in contexts such as "there are three separate groups: progressives, conservatives, and neoliberals"; "it was the Progressives that kicked off associational, communitarian ideals". It most often appears alongside India, OpenAI, 2020 election.

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Grading My 2018 Predictions For 2023
February 20, 2023 · Original source
It will become more and more apparent that there are three separate groups: progressives, conservatives, and neoliberals. How exactly they sort themselves into two parties is going to be interesting. The easiest continuation-of-current-trends option is neoliberals+progressives vs. conservatives, with neoliberals+progressives winning easily. But progressives are starting to wonder if neoliberals’ support is worth the watering-down of their program, and neoliberals are starting to wonder if progressives’ support is worth constantly feeding more power to people they increasingly consider crazy. The Republicans used some weird demonic magic to hold together conservatives and neoliberals for a long time; I suspect the Democrats will be less good at this. A weak and fractious Democratic coalition plus a rock-hard conservative Republican non-coalition might be stable under Median Voter Theorem considerations. For like ten years. Until there are enough minorities that the Democrats are just overwhelmingly powerful (no, minorities are not going to start identifying as white and voting Republican en masse). I have no idea what will happen then. Maybe the Democrats will go extra socialist, the neoliberals and market minorities will switch back to the Republicans, and we can finally have normal reasonable class warfare again instead of whatever weird ethno-cultural thing is happening now?
Highlights From The Comments On Liberalism And Communities
August 12, 2025 · Original source
We ended the Gilded Age fractured and alone, and built up civic associational life, communitarian ideals, etc. from around 1900 to around 1960, after which all those indicators start plunging in all the charts you see everywhere today. But because we have been so focused on the last 60-odd years of data, we have missed the incredibly important context of the (titular) upswing that occurred in the first half of the 20th century in America and didn't require populism (in fact, the Populist movement in America was strongest right BEFORE the upswing began, ~1870-1900), and it was the Progressives that kicked off associational, communitarian ideals. This increase in community and togetherness was a strong trend through the Great Depression, the New Deal, and the Postwar years. It wasn't costless! There were reasons people rebelled against the reigning order in the 1960s and 1970s. But every solution creates its own problems, and I think making this about Modernity and not about the last 65 years of culture obscures the contours of the issue.
Proposition 132 mentions across 2 issues

Proposition 13 is a recurring concept in the Astral Codex Ten archive, appearing 2 times across 2 issues between December 09, 2021 and September 11, 2023. The archive places it in contexts such as "Let's put aside Proposition 13's legacy in California for a second"; "Proposition 13 related tax shenanigans"; "I don’t know enough about how Proposition 13 works to contradict this". It most often appears alongside China, France, New York City.

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Does Georgism Work? Part 1: Is Land Really A Big Deal?
December 09, 2021 · Original source
And for two, property tax assessments have all kinds of exemptions and carve-outs that serve to depress official statistics. Let's put aside Proposition 13's legacy in California for a second and just compare the sale history to the tax history of properties like this one in Manhattan:
Inline links: Proposition 13
Highlights From The Comments On Last Week's Model Cities Post
September 11, 2023 · Original source
I would be shocked in Proposition 13 related tax shenanigans are not underlying a major part of the Solano "new city" development. Having valuations increase is great - but having to pay almost no taxes on it is a major force multiplier. As I have noted before: people who bought property in Pacific Heights in the late 70s and early 80s now pay annual property tax that is less than 1 month's rent for a 1 bedroom in SF - and there are many ways to make this intergenerational.
I don’t know enough about how Proposition 13 works to contradict this, although my understanding is that if they sell the land (eg to developers or homeowners) that negates this benefit.
prospect theory2 mentions across 2 issues

prospect theory is a recurring concept in the Astral Codex Ten archive, appearing 2 times across 2 issues between August 30, 2021 and August 31, 2023. The archive places it in contexts such as "This is Behavioral Econ 101 stuff - and prospect theory"; "developing Prospect Theory—their grand theory with loss aversion at its center"; "popular theory which won Kahneman the Nobel Prize". It most often appears alongside Gal & Rucker, Kahneman, loss aversion.

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On Hreha On Behavioral Economics
August 30, 2021 · Original source
This is Behavioral Econ 101 stuff - risk aversion, loss aversion, and prospect theory. If it’s true, the core of behavioral economics is salvageable. There might be some bad studies built on top of that core, but the basic insights are right.
Inline links: risk aversion, loss aversion, prospect theory
I find I usually click the third box on both. I want to tip generously, but giving the maximum possible tip seems profligate. Surely the third box is the right compromise. I recently noticed that this is insane. For a $35 meal, I’m giving GrubHub drivers $3 and UberEats drivers $7 for the same service (or maybe there’s some difference between their services which makes UberEats suggest the higher tip - but if there is, I don’t know about it and it doesn’t affect my decision). Again, this is Behavioral Economics 101 - in particular, one of the many biases lumped together under menu effects. Instead of being a rational economic actor who values food delivery at a certain price, I’m trying to be a third-box-of-four kind of guy. That means that whoever is in charge of this menu has lots of power over the specific dollar amount I give. Not infinite power - if the third box said $1000 I would notice and refuse. But enough power that “nudging” seems like a fair description. Nobody believes studies anymore, which is fair. I trust in a salvageable core of behavioral economics and “nudgenomics” because I can feel in my bones that they’re true for me and the people around me. Let’s move on to Hreha’s article and see if we can square it with my belief in a “salvageable core”. II. Yechaim’s Historical Detective Story Hreha writes: The biggest replication failures relate to the field's most important idea: loss aversion. To be honest, this was a finding that I lost faith in well before the most recent revelations (from 2018-2020). Why? Because I've run studies looking at its impact in the real world—especially in marketing campaigns. If you read anything about this body of research, you'll get the idea that losses are such powerful motivators that they'll turn otherwise uninterested customers into enthusiastic purchasers. The truth of the matter is that losses and benefits are equally effective in driving conversion. In fact, in many circumstances, losses are actually *worse* at driving results. Why? Because loss-focused messaging often comes across as gimmicky and spammy. It makes you, the advertiser, look desperate. It makes you seem untrustworthy, and trust is the foundation of sales, conversion, and retention. "So is loss aversion completely bogus?" Not quite. It turns out that loss aversion does exist, but only for large losses. This makes sense. We *should* be particularly wary of decisions that can wipe us out. That's not a so-called "cognitive bias". It's not irrational. In fact, it's completely sensical. If a decision can destroy you and/or your family, it's sane to be cautious. "So when did we discover that loss aversion exists only for large losses?" Well, actually, it looks like Kahneman and Tversky, winners of the Nobel Prize in Economics, knew about this unfortunate fact when they were developing Prospect Theory—their grand theory with loss aversion at its center. Unfortunately, the findings rebutting their view of loss aversion were carefully omitted from their papers, and other findings that went against their model were misrepresented so that they would instead support their pet theory. In short: any data that didn't fit Prospect Theory was dismissed or distorted. I don't know what you'd call this behavior... but it's not science. This shady behavior by the two titans of the field was brought to light in a paper published in 2018: "Acceptable Losses: The Debatable Origins of Loss Aversion". I encourage you to read the paper. It's shocking. This line from the abstract sums things up pretty well: "...the early studies of utility functions have shown that while very large losses are overweighted, smaller losses are often not. In addition, the findings of some of these studies have been systematically misrepresented to reflect loss aversion, though they did not find it." When the two biggest scientists in your field are accused of "systemic misrepresentation", you know you've got a serious problem. Which leads us to another paper, published in 2018, entitled "The Loss of Loss Aversion: Will It Loom Larger Than Its Gain?". The paper's authors did a comprehensive review of the loss aversion literature and came to the following conclusion: "current evidence does not support that losses, on balance, tend to be any more impactful than gains." Yikes. But given the questionable origins of the field, it's not surprising that its foundational finding is *also* dubious. If loss aversion can't be trusted, then no other idea in the field can be trusted. This argument relies on two papers - Yechaim’s Acceptable Losses and Gal & Rucker’s Loss Of Loss Aversion. Yechaim’s paper is a historical detective story. It looks at how Kahneman and Tversky first “discovered” and popularized the idea of loss aversion from earlier 1950s and 1960s research. It concludes they did a bad job summarizing this earlier research; looked at carefully, it doesn’t support the strong conclusions they drew. From one perspective, nobody should care about this. All the 1950s and 1960s research was terrible - one of the most important studies it discusses had n = 7. Since then, we’ve had much more rigorous studies of tens of thousands of people. All that hinges on Yechaim’s paper is whether Kahneman and Tversky were personally bad people. Hreha thinks they were. He calls their behavior “shady”, “shocking”, and says they “systematically misrepresented findings to support their pet theory…I don't know what you'd call this behavior... but it's not science.” Again, nothing important really hinges on this, but I feel like fighting about it, so let’s look deeper anyway. Here’s how Yechaim summarizes his accusation against K&T: In addition, the results of several studies seem to have been misrepresented by Fishburn and Kochenberger (1979) and Kahneman and Tversky (1979). Galenter and Pliner (1974) were wrongly cited as showing loss aversion, whereas, in fact, they did not observe an asymmetry in the pleasantness ratings of gains and losses. Likewise, in Green (1963), the results were argued to show loss aversion, even though this study did not involve any losses. In addition, the objective outcomes for some of the participants in Grayson (1960) were transformed by Fishburn and Kochenberger (1979) so as to better support a model assuming different curvatures for gains and losses (see Table 1). Finally, studies showing no loss aversion or suggesting aversion to large losses were not cited in Fishburn and Kochenberger (1979) or in Kahneman and Tversky (1979). Yechaim bases his argument on three sets of early studies of loss aversion: Galenter and Plinter (1974), Fishburn and Kochenberger’s review (1979) and miscellaneous others. —Galenter and Plinter— is actually really neat! It explores “cross-modal” perceptions of gains versus losses. That is, if you ask how much a certain loss hurt, people will probably just say something like “I dunno, a little?” and then it will be hard to turn that into a p-value. G&P solve this by making people listen to loud noises, and asking questions like “is the difference between how much loss A and loss B hurt greater or lesser than the difference between the volume of noise 1 and noise 2?” The idea is that the brain uses a bunch of weird non-numerical scales for everything, and we understand its weird-non-numerical scale for noise volume pretty well, and so maybe we can compare it to how people think about gains or losses. I don’t know why people in 1974 were doing anything this complicated instead of inventing the basic theory of loss aversion the way Kahneman and Tversky would five years later, but here we are. Anyway, Yechaim concludes that this study failed to find loss aversion: Summing up their findings, Galenter and Pliner (1974) reported as follows: “We now turn to the question of the possible asymmetry of the positive and negative limbs of the utility function. On the basis of intuition and anecdote, one would expect the negative limb of the utility function to decrease more sharply than the positive limb increases... what we have observed if anything is an asymmetry of much less magnitude than would have been expected ... the curvature of the function does not change in going from positive to negative” (p. 75). Thus, our search for the historical foundations of loss aversion turns into a dead end on this particular branch: Galenter and Pliner (1974) did not observe such an asymmetry; and their study was quoted erroneously [by Kahneman and Tversky]. I looked for the full text of Galenter and Pliner, but could not find it. I was however able to find the first two pages, including the abstract. The way Galenter and Pliner summarize their own research is: Cross-modality matching of hypothetical increments of money against loudness recover the previously proposed exponent of the utility function for money within a few percent. Similar cross-modality matching experiments for decrements give a disutility exponent of 0.59, larger than the utility exponent for increments. This disutility exponent was checked by an additional cross-modality matching experiment against the disutility of drinking various concentrations of a bitter solution. The parameter estimated in this fashion was 0.63. If I understand the bolded part right, the abstract seems to be saying that they did find loss aversion! I was also able to find the Google Books listing for the book that the study was published in. Its summary is: Three experiments were conducted in which monetary increments and decrements were matched to either the loudness of a tone or the bitterness of various concentrations of sucrose octa-acetate. An additional experiment involving ratio estimates of monetary loss is also reported. Results confirm that the utility function for both monetary increments and decrements is a power function with exponents less than one. The data further suggest that the exponent of the disutility function is larger than that of the utility function, i.e., the rate of change of 'unhappiness' caused by monetary losses is greater than the comparable rate of 'happiness' produced by monetary gains. (Author). Again, the way the book is summarized (apparently by the author) says this study does prove loss aversion. Without being able to access the full study, I’m not sure what’s going on. Possibly the study found loss aversion, but it was less than expected? Still, I feel like Yechaim should have mentioned this. At the very least, it decreases Kahneman and Tversky’s crime from “lied about a study to support their pet theory” to “credulously believed the authors’ own summary of their results and didn’t dig deeper”. But also, why did the authors believe their study showed loss aversion? Why does Yechaim disagree? Without being able to access the full paper, I’m not sure. —Green 1963— is the second study that Yechaim accuses K&T of misrepresenting. Here’s how K&T cite this study in their paper: It is of interest that the main properties ascribed to the value function have been observed in a detailed analysis of von Neumann-Morgenstern utility functions for changes of wealth (Fishburn and Kochenberger [14]). The functions had been obtained from thirty decision makers in various fields of business, in five independent studies [5, 18, 19, 21, 40]. Most utility functions for gains were concave, most functions for losses were convex, and only three individuals exhibited risk aversion for both gains and losses. With a single exception, utility functions were considerably steeper for losses than for gains. Green 1963 is footnote 19. So K&T don’t even mention it by name. They mention it as one of several studies that a review article called Fishburn and Kochenberger analyzes. F&K are reviewing a bunch of studies of executives. In each study, a very small number of executives (usually about 5-10 per study) make a hypothetical business decision comparing gains and losses, for example: Suppose your company is being sued for patent infringement. Your lawyer’s best judgement is that your chances of winning the suit are 50–50; if you win, you will lose nothing, but if you lose, it will cost the company $1,000,000. Your opponent has offered to settle out of court for $200,000. Would you fight or settle? Then they ask the same question with a bunch of other numbers, and plot implied utility functions for each executive based on the answer. Green is one of these five studies, and it does superficially find loss aversion. But Fishburn and Kochenberger have done something weird. They argue that “loss” and “gain” aren’t necessarily objective, and usually correspond to “loss relative to some reference frame” (so far, so good). In order to figure out where the reference frame is, they assume that the neutral point is wherever “something unusual happens to the individual’s utility function” (F&K’s words). So they shift the zero point separating losses and gains to wherever the utility function looks most interesting! After doing this, they find “loss aversion”, ie the utility curve changes its slope at the transition between the loss side and the gain side. But since the transition was deliberately shifted to wherever the utility curve changed slope, this is almost tautological. It isn’t quite tautological: it’s interesting that most of the utility curves had a sharp transition zone, and it’s interesting that the transition was in the direction of loss-aversion rather than gain-seeking. But it’s tautological enough to be embarrassing. Still, this is Fishburn and Kochenberger’s embarrassment, not Kahneman and Tversky’s. And Fishburn and Kochenberger included this study in their review alongside several other studies that didn’t do this to the same degree. Kahneman and Tversky just cited the review article. I don’t think citing a review article that does weird things to a study really qualifies as “systematic misrepresentation.” I guess I’m having a hard time figuring out how angry to be, because everything about Fishburn and Kochenberger is terrible. The average study in F&K includes results from 5-10 executives. But the studies are pretty open about the fact that they interviewed more executives than this, threw away the ones who gave boring answers, and just published results from the interesting ones. Then they moved the axes to wherever looked most interesting. Then they used all this to draw sweeping generalizations about human behavior. Then F&K combined five studies that did this into a review article, without protesting any of it. And then K&T cited the review article, again without protesting. I have to imagine that all of this was normal by the standards of the time. I have looked up all these people and they were all esteemed scientists in their own day. And I believe the evidence shows K&T summarized F&K faithfully. Shouldn’t they have avoided citing F&K at all? Seems like the same kind of question as “Shouldn’t Pythagoras have published his theorem in a peer-reviewed journal, instead of moving to Italy, starting a cult, and exposing his thigh at the Olympic Games as part of a scheme to convince people he was the god Apollo?” Yes, but the past was a weird place. As best I can tell, K&T’s citation of G&P agrees with the authors’ own assessment of their results. Their citation of F&K agrees with the reviewers’ assessment and with a charitable reading of most of the studies involved, although those studies are terrible in many ways which are obvious to modern readers. I would urge people interested in the whodunit question to read Kahneman and Tversky’s original paper. I think it paints the picture of a team very interested in their own results and in theory, and citing other people only incidentally, and in accordance with the scientific standards of their time. I don’t feel a need to tar them as “misrepresenters”. III. Okay, But Is Loss Aversion Real? Remember, all that is about the personal deficiencies of Kahneman and Tversky. Realistically there have been hundreds of much better studies on loss aversion in the forty years since they wrote their article, so we should be looking at those. Here Hreha cites Gal & Rucker: The Loss Of Loss Aversion: Will It Loom Larger Than Its Gain? It’s a great 2018 paper that looks at recent evidence and concludes that loss aversion doesn’t exist. But it’s a very specific, interesting type of nonexistence, which I think the Hreha article fails to capture. G&R are happy to admit that in many, many cases, people behave in loss-averse ways, including most of the classic examples given by Kahneman and Tversky. They just think that this is because of other cognitive biases, not a specific cognitive bias called “loss aversion”. They especially emphasize Status Quo Bias and the Endowment Effect. Status Quo Bias is where you prefer inaction to action. Suppose you ask someone “Would you bet on a coin flip, where you get $60 if heads and lose $40 if tails?”. They say no. This deviates from rational expectations, and one way to think of this is loss aversion; the prospect of losing $40 feels “bigger” than the prospect of gaining $60. But another way to think of it is as a bias towards inaction - all else being equal, people prefer not to make bets, and you’d need a higher payoff to overcome their inertia. Endowment Effect is where you value something you already have more than something you don’t. Suppose someone would pay $5 to prevent their coffee mug from being taken away from them, but (in an alternative universe where they lack a coffee mug) would only pay $3 to buy one. You can think of this as loss aversion (the grief of losing a coffee mug feels “bigger” than the joy of gaining one). Or you can think of it as endowment (once you have the coffee mug, it’s yours and you feel like defending it). These are really fine distinctions; I had to read the section a few times before the difference between loss aversion and endowment effect really made sense to me. Kahneman and Tversky just sort of threw all all this stuff out and saw what stuck and didn’t necessarily try super hard to make sure none of the biases they discovered were entirely explainable as combinations of some of the others. G&R think maybe loss aversion is. They do some clever work setting up situations that test loss aversion but not status quo or endowment - for example, offering a risky bet vs. a safer bet. Here they find no evidence for loss aversion as a separate force from the other two biases. Somewhere in this process, they did an experiment where they gave participants a quarter minted in Denver and asked them if they wanted to exchange it for a quarter minted in Philadelphia. 60% of people very reasonably didn’t care, but another 35% had grown attached to their Denver quarter, with only 5% actively seeking the novelty of Philadelphia. Psychology is weird. I understand why some people would summarize this paper as “loss aversion doesn’t exist”. But it’s very different from “power posing doesn’t exist” or “stereotype threat doesn’t exist”, where it was found that the effect people were trying to study just didn’t happen, and all the studies saying it did were because of p-hacking or publication bias or something. People are very often averse to losses. This paper just argues that this isn’t caused by a specific “loss aversion” force. It’s caused by other forces which are not exactly loss aversion. We could compare it to centrifugal force in physics: real, but not fundamental. Also, you can’t use this paper to argue that “behavioral economics is dead”. At best, the paper proves that loss aversion is better explained by other behavioral economic concepts. But you can’t get rid of behavioral econ entirely! The stuff you have to explain is still there! It’s just a question of which parts of behavioral econ you use to explain it. Complicating this even further is Mrkva et al, Loss Aversion Has Moderators, But Reports Of Its Death Are Greatly Exaggerated (h/t Alex Imas, who has a great Twitter thread about this). This is an even newer paper, 2019, which argues that Gal and Rucker are wrong, and loss aversion does have an independent existence as a real force. There are many things to like about this paper. Previous criticisms of loss aversion argue that most experiments are performed on undergrads, who are so poor that even small amounts of money might have unusual emotional meaning. Mrkva collects a sample of thousands of millionaires (!) and demonstrates that they show loss aversion for sums of money as small as $20. On the other hand, I’m not sure they’re quite as careful as G&R at ruling out every other possible bias (although I don’t have a great understanding of where the borders between biases are and I can’t say this for sure). The main point I want to make is that all the scientists in this debate seem smart, thoughtful, and impressive. This isn’t like social priming experiments where one person says a crazy thing, nobody ever replicates it at scale, and as soon as someone tries the whole thing collapses. These have been replicated hundreds of times, with the remaining arguments being complicated semantic and philosophical ones about how to distinguish one theory from a very slightly different theory. If that takes replicating your result on a sample of thousands of millionaires, people will gather a sample of thousands of millionaires and get busy on the replication. Just overall really impressive work. I don’t feel qualified to take a side in the G&R vs. Mkrva debate, but both teams make me really happy that there are smart and careful people considering these questions. And this is just a drop in the bucket. Alex Imas also links Replicating patterns of prospect theory for decision under risk, which says: Though substantial evidence supports prospect theory, many presumed canonical theories have drawn scrutiny for recent replication failures. In response, we directly test the original methods in a multinational study (n = 4,098 participants, 19 countries, 13 languages), adjusting only for current and local currencies while requiring all participants to respond to all items. The results replicated for 94% of items, with some attenuation. Twelve of 13 theoretical contrasts replicated, with 100% replication in some countries. Heterogeneity between countries and intra-individual variation highlight meaningful avenues for future theorizing and applications. We conclude that the empirical foundations for prospect theory replicate beyond any reasonable thresholds. Beyond any reasonable thresholds! IV. Do Nudges Work? or, How Small Is Small? Continuing through the Hreha article: For a number of years, I've been beating the anti-nudge drum. Since 2011, I've been running behavioral experiments in the wild, and have always been struck by how weak nudges tend to be. In my experience, nudges usually fail to have *any* recognizable impact at all. This is supported by a paper that was recently published by a couple of researchers from UC Berkeley. They looked at the results of 126 randomized controlled trials run by two "nudge units" here in the United States. I want you to guess how large of an impact these nudges had on average... 30%? 20%? 10%? 5%? 3%? 1.5%? 1%? 0%? If you said 1.5%, you'd be right (the actual number is 1.4%, but if I had written that out you would have chosen it because of its specificity). According to the academic papers these nudges were based upon, these nudges should have had an average impact of 8.7%. But, as you probably understand by now, behavioral economics is not a particularly trustworthy field. I actually emailed the authors of this paper, and they thought the ~1% effect size of these interventions was something to be applauded—especially if the intervention was cheap & easy. Unfortunately, no intervention is truly cheap or easy. Every single intervention requires, at the very minimum, administrative overhead. If you're going to do something, you need someone (or some system) to implement and keep track of it. If an intervention is only going to get you a 1% improvement, it's probably not even worth it. Uber infamously had a team of behavioral economists working on its product, trying to “nudge” people in the right direction. Relatedly, Uber makes $10 billion in yearly revenue. If they can “nudge” people to spend 1% more, that’s $100 million. That’s not much relative to revenue, but it’s a lot in absolute terms. In particular, it pays the salary of a lot of behavioral economists. If you can hire 10 behavioral economists for $100,000 a year and make $100 million, that’s $99 million in profit. Or what if you’re a government agency, trying to nudge people to do prosocial things? There are about 90 million eligible Americans who haven’t gotten their COVID vaccine, and although some of them are hard-core conspiracy theorists, others are just lazy or nervous or feel safe already. (source) Whoever decided on that grocery gift card scheme was nudging, whether or not they have an economics degree - and apparently they were pretty good at it. If some sort of behavioral econ campaign can convince 1.5% of those 90 million Americans to get their vaccines, that’s 1.4 million more vaccinations and, under reasonable assumptions, maybe a few thousand lives saved. Hreha says that: Every single intervention requires, at the very minimum, administrative overhead. If you're going to do something, you need someone (or some system) to implement and keep track of it. If an intervention is only going to get you a 1% improvement, it's probably not even worth it. This depends on scale! 1% of a small number isn’t worth it! 1% of a big number is very worth it, especially if that big number is a number of lives! A few caveats. First, a small number only matters if it’s real. It’s very easy to get spurious small effects, so much so that any time you see a small effect you should wonder if it’s real. I’m ready to be forgiving here because behavioral economics is so well-replicated and common-sensically true, but I wouldn’t blame anyone who steers clear. Second, Hreha says: To be honest, you can probably use your creativity to brainstorm an idea that will get you a 3-4% minimum gain, no behavioral economics "science" required. Which leads me to the final point I'd like to make: rules and generalizations are overrated. The reason that fields like behavioral economics are so seductive is because they promise people easy, cookie-cutter solutions to complicated problems. Figuring out how to increase sales of your product is hard. You need to figure out which variables are responsible for the lackluster interest. Is the price the issue? Is the product too hard to use? Is the design tacky? Is the sales organization incompetent? Is the refund/return policy lacking? etc. Exploring these questions can take months (or years) of hard work, and there's no guarantee that you'll succeed. If, however, a behavioral economist tells you that there are nudges that will increase your sales by 10%, 20%, or 30% without much effort on your part... Whoa. That's pretty cool. It's salvation. Thus, it's no surprise that governments and companies have spent hundreds of millions of dollars on behavioral "nudge" units. Unfortunately, as we've seen, these nudges are woefully ineffective. Specific problems require specific solutions. They don't require boilerplate solutions based on general principles that someone discovered by studying a bunch of 19 year old college students. However, the social sciences have done a good job of convincing people that general principles are better solutions for problems than creative, situation-specific solutions. In my experience, creative solutions that are tailor-made for the situation at hand *always* perform better than generic solutions based on one study or another. Hreha is a professional in this field, so presumably he’s right. Still, compare to medicine. A thoughtful doctor who tailors treatment to a particular patient sounds better (and is better) than one who says “Depression? Take this one all-purpose depression treatment which is the first thing I saw when I typed ‘depression’ into UpToDate”. But you still need medical journals. Having some idea of general-purpose laws is what gives the people making creative solutions something to build upon. (also, at some point your customers might want to check your creative solution to see whether it actually gives a “3-4% minimum gain, no behavioral economics required”, and that would be at least vaguely study-shaped.) Third, everyone who said nudging had vast effects is still bad and wrong. Many of them were bad and wrong and making fortunes consulting for companies about how to implement the policies they were claiming were super-powerful. This is suspicious and we should lower our opinion of them accordingly. In a previous discussion of growth mindset, I wrote: Imagine I claimed our next-door neighbor was a billionaire oil sheik who kept thousands of boxes of gold and diamonds hidden in his basement. Later we meet the neighbor, and he is the manager of a small bookstore and has a salary 10% above the US average... Should we describe this as “we have confirmed the Wealthy Neighbor Hypothesis, though the effect size was smaller than expected”? Or as “I made up a completely crazy story, and in unrelated news there was an irrelevant deviation from literally-zero in the same space”? All the people talking about oil sheiks deserve to get asked some really uncomfortable questions. And a lot of these will be the most famous researchers - the Dan Arielys of the world - because of course the people who successfully hyped their results a lot are the ones the public knows about. Still, the neighbor seems like a neat guy, and maybe he’ll give you a job at his bookstore. V. Conclusion: Musings On The Identifiable Victim Effect I actually skipped the very beginning of Hreha’s article. I want to come back to it now. It begins: The last few years have been particularly bad for behavioral economics. A number of frequently cited findings have failed to replicate. Here are a couple of high profile examples: The Identifiable Victim Effect (featured in the workbooks I wrote with Dan Ariely and Kristen Berman in 2014)
Inline links: menu effects, Acceptable Losses: The Debatable Origins of Loss Aversion, The Loss of Loss Aversion: Will It Loom Larger Than Its Gain?, Acceptable Losses, Loss Of Loss Aversion, the first two pages, https://substackcdn.com/image/fetch/$s_!W80n!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F7f832933-e9a1-4cf2-ba32-e4bc11ce681c_830x624.png, Kahneman and Tversky’s original paper, https://substackcdn.com/image/fetch/$s_!2VLm!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F8c49b44a-8850-4ac8-9a88-3dd07718a648_397x305.png, Loss Aversion Has Moderators, But Reports Of Its Death Are Greatly Exaggerated, Alex Imas, Replicating patterns of prospect theory for decision under risk, They looked at the results of 126 randomized controlled trials, others, https://substackcdn.com/image/fetch/$s_!1gY_!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F5b127d7c-045a-4266-b515-a0e9201ce651_571x382.png, a previous discussion of growth mindset, the workbooks I wrote with Dan Ariely and Kristen Berman in 2014
Somewhere in this process, they did an experiment where they gave participants a quarter minted in Denver and asked them if they wanted to exchange it for a quarter minted in Philadelphia. 60% of people very reasonably didn’t care, but another 35% had grown attached to their Denver quarter, with only 5% actively seeking the novelty of Philadelphia. Psychology is weird. I understand why some people would summarize this paper as “loss aversion doesn’t exist”. But it’s very different from “power posing doesn’t exist” or “stereotype threat doesn’t exist”, where it was found that the effect people were trying to study just didn’t happen, and all the studies saying it did were because of p-hacking or publication bias or something. People are very often averse to losses. This paper just argues that this isn’t caused by a specific “loss aversion” force. It’s caused by other forces which are not exactly loss aversion. We could compare it to centrifugal force in physics: real, but not fundamental. Also, you can’t use this paper to argue that “behavioral economics is dead”. At best, the paper proves that loss aversion is better explained by other behavioral economic concepts. But you can’t get rid of behavioral econ entirely! The stuff you have to explain is still there! It’s just a question of which parts of behavioral econ you use to explain it. Complicating this even further is Mrkva et al, Loss Aversion Has Moderators, But Reports Of Its Death Are Greatly Exaggerated (h/t Alex Imas, who has a great Twitter thread about this). This is an even newer paper, 2019, which argues that Gal and Rucker are wrong, and loss aversion does have an independent existence as a real force. There are many things to like about this paper. Previous criticisms of loss aversion argue that most experiments are performed on undergrads, who are so poor that even small amounts of money might have unusual emotional meaning. Mrkva collects a sample of thousands of millionaires (!) and demonstrates that they show loss aversion for sums of money as small as $20. On the other hand, I’m not sure they’re quite as careful as G&R at ruling out every other possible bias (although I don’t have a great understanding of where the borders between biases are and I can’t say this for sure). The main point I want to make is that all the scientists in this debate seem smart, thoughtful, and impressive. This isn’t like social priming experiments where one person says a crazy thing, nobody ever replicates it at scale, and as soon as someone tries the whole thing collapses. These have been replicated hundreds of times, with the remaining arguments being complicated semantic and philosophical ones about how to distinguish one theory from a very slightly different theory. If that takes replicating your result on a sample of thousands of millionaires, people will gather a sample of thousands of millionaires and get busy on the replication. Just overall really impressive work. I don’t feel qualified to take a side in the G&R vs. Mkrva debate, but both teams make me really happy that there are smart and careful people considering these questions. And this is just a drop in the bucket. Alex Imas also links Replicating patterns of prospect theory for decision under risk, which says: Though substantial evidence supports prospect theory, many presumed canonical theories have drawn scrutiny for recent replication failures. In response, we directly test the original methods in a multinational study (n = 4,098 participants, 19 countries, 13 languages), adjusting only for current and local currencies while requiring all participants to respond to all items. The results replicated for 94% of items, with some attenuation. Twelve of 13 theoretical contrasts replicated, with 100% replication in some countries. Heterogeneity between countries and intra-individual variation highlight meaningful avenues for future theorizing and applications. We conclude that the empirical foundations for prospect theory replicate beyond any reasonable thresholds. Beyond any reasonable thresholds! IV. Do Nudges Work? or, How Small Is Small? Continuing through the Hreha article: For a number of years, I've been beating the anti-nudge drum. Since 2011, I've been running behavioral experiments in the wild, and have always been struck by how weak nudges tend to be. In my experience, nudges usually fail to have *any* recognizable impact at all. This is supported by a paper that was recently published by a couple of researchers from UC Berkeley. They looked at the results of 126 randomized controlled trials run by two "nudge units" here in the United States. I want you to guess how large of an impact these nudges had on average... 30%? 20%? 10%? 5%? 3%? 1.5%? 1%? 0%? If you said 1.5%, you'd be right (the actual number is 1.4%, but if I had written that out you would have chosen it because of its specificity). According to the academic papers these nudges were based upon, these nudges should have had an average impact of 8.7%. But, as you probably understand by now, behavioral economics is not a particularly trustworthy field. I actually emailed the authors of this paper, and they thought the ~1% effect size of these interventions was something to be applauded—especially if the intervention was cheap & easy. Unfortunately, no intervention is truly cheap or easy. Every single intervention requires, at the very minimum, administrative overhead. If you're going to do something, you need someone (or some system) to implement and keep track of it. If an intervention is only going to get you a 1% improvement, it's probably not even worth it. Uber infamously had a team of behavioral economists working on its product, trying to “nudge” people in the right direction. Relatedly, Uber makes $10 billion in yearly revenue. If they can “nudge” people to spend 1% more, that’s $100 million. That’s not much relative to revenue, but it’s a lot in absolute terms. In particular, it pays the salary of a lot of behavioral economists. If you can hire 10 behavioral economists for $100,000 a year and make $100 million, that’s $99 million in profit. Or what if you’re a government agency, trying to nudge people to do prosocial things? There are about 90 million eligible Americans who haven’t gotten their COVID vaccine, and although some of them are hard-core conspiracy theorists, others are just lazy or nervous or feel safe already. (source) Whoever decided on that grocery gift card scheme was nudging, whether or not they have an economics degree - and apparently they were pretty good at it. If some sort of behavioral econ campaign can convince 1.5% of those 90 million Americans to get their vaccines, that’s 1.4 million more vaccinations and, under reasonable assumptions, maybe a few thousand lives saved. Hreha says that: Every single intervention requires, at the very minimum, administrative overhead. If you're going to do something, you need someone (or some system) to implement and keep track of it. If an intervention is only going to get you a 1% improvement, it's probably not even worth it. This depends on scale! 1% of a small number isn’t worth it! 1% of a big number is very worth it, especially if that big number is a number of lives! A few caveats. First, a small number only matters if it’s real. It’s very easy to get spurious small effects, so much so that any time you see a small effect you should wonder if it’s real. I’m ready to be forgiving here because behavioral economics is so well-replicated and common-sensically true, but I wouldn’t blame anyone who steers clear. Second, Hreha says: To be honest, you can probably use your creativity to brainstorm an idea that will get you a 3-4% minimum gain, no behavioral economics "science" required. Which leads me to the final point I'd like to make: rules and generalizations are overrated. The reason that fields like behavioral economics are so seductive is because they promise people easy, cookie-cutter solutions to complicated problems. Figuring out how to increase sales of your product is hard. You need to figure out which variables are responsible for the lackluster interest. Is the price the issue? Is the product too hard to use? Is the design tacky? Is the sales organization incompetent? Is the refund/return policy lacking? etc. Exploring these questions can take months (or years) of hard work, and there's no guarantee that you'll succeed. If, however, a behavioral economist tells you that there are nudges that will increase your sales by 10%, 20%, or 30% without much effort on your part... Whoa. That's pretty cool. It's salvation. Thus, it's no surprise that governments and companies have spent hundreds of millions of dollars on behavioral "nudge" units. Unfortunately, as we've seen, these nudges are woefully ineffective. Specific problems require specific solutions. They don't require boilerplate solutions based on general principles that someone discovered by studying a bunch of 19 year old college students. However, the social sciences have done a good job of convincing people that general principles are better solutions for problems than creative, situation-specific solutions. In my experience, creative solutions that are tailor-made for the situation at hand *always* perform better than generic solutions based on one study or another. Hreha is a professional in this field, so presumably he’s right. Still, compare to medicine. A thoughtful doctor who tailors treatment to a particular patient sounds better (and is better) than one who says “Depression? Take this one all-purpose depression treatment which is the first thing I saw when I typed ‘depression’ into UpToDate”. But you still need medical journals. Having some idea of general-purpose laws is what gives the people making creative solutions something to build upon. (also, at some point your customers might want to check your creative solution to see whether it actually gives a “3-4% minimum gain, no behavioral economics required”, and that would be at least vaguely study-shaped.) Third, everyone who said nudging had vast effects is still bad and wrong. Many of them were bad and wrong and making fortunes consulting for companies about how to implement the policies they were claiming were super-powerful. This is suspicious and we should lower our opinion of them accordingly. In a previous discussion of growth mindset, I wrote: Imagine I claimed our next-door neighbor was a billionaire oil sheik who kept thousands of boxes of gold and diamonds hidden in his basement. Later we meet the neighbor, and he is the manager of a small bookstore and has a salary 10% above the US average... Should we describe this as “we have confirmed the Wealthy Neighbor Hypothesis, though the effect size was smaller than expected”? Or as “I made up a completely crazy story, and in unrelated news there was an irrelevant deviation from literally-zero in the same space”? All the people talking about oil sheiks deserve to get asked some really uncomfortable questions. And a lot of these will be the most famous researchers - the Dan Arielys of the world - because of course the people who successfully hyped their results a lot are the ones the public knows about. Still, the neighbor seems like a neat guy, and maybe he’ll give you a job at his bookstore. V. Conclusion: Musings On The Identifiable Victim Effect I actually skipped the very beginning of Hreha’s article. I want to come back to it now. It begins: The last few years have been particularly bad for behavioral economics. A number of frequently cited findings have failed to replicate. Here are a couple of high profile examples: The Identifiable Victim Effect (featured in the workbooks I wrote with Dan Ariely and Kristen Berman in 2014)
Inline links: Loss Aversion Has Moderators, But Reports Of Its Death Are Greatly Exaggerated, Alex Imas, Replicating patterns of prospect theory for decision under risk, They looked at the results of 126 randomized controlled trials, others, https://substackcdn.com/image/fetch/$s_!1gY_!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F5b127d7c-045a-4266-b515-a0e9201ce651_571x382.png, a previous discussion of growth mindset, the workbooks I wrote with Dan Ariely and Kristen Berman in 2014
Here's Why Automaticity Is Real Actually
August 31, 2023 · Original source
The big prospect theory replication paper concluded that “the empirical foundations for prospect theory replicate beyond any reasonable thresholds.”
Inline links: The big prospect theory replication paper
The big prospect theory replication paper concluded that “the empirical foundations for prospect theory replicate beyond any reasonable thresholds.” These aren’t minor points; prospect theory won Kahneman the Nobel Prize. When people talk about “cognitive biases”, these are the kinds of things they’re talking about. Most Priming Replicates And Is Real Psychologists have been researching priming since the 1950s. Most forms of priming replicate just fine, but since nobody believes studies anymore, here are a few experiments you can try at home to see if they work on you: 1: Word Scrambles Quick, unscramble these as fast as you can! CHCURH
Inline links: The big prospect theory replication paper
psychedelics2 mentions across 2 issues

psychedelics is a recurring concept in the Astral Codex Ten archive, appearing 2 times across 2 issues between February 13, 2021 and August 08, 2021. The archive places it in contexts such as "ketamine and psychedelics, which is a good match for ketamine-assisted and psychedelic-assisted therapies"; "Psychedelics are pretty well-tested (albeit informally) for things like chronic pain". It most often appears alongside 5-HT2A receptors, AMPA receptors, ampakines.

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psychedelics
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February 13, 2021
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The Precision Of Sensory Evidence
February 13, 2021 · Original source
Fourth, what do we know about all of this pharmacologically? Priors seem to be encoded in NMDA receptors and their relative strength modulated by 5-HT2A receptors, so if you wanted to downweight priors (and so relatively upweight sensory evidence), you would want NDMA antagonists or 5-HT2A agonists. That would mean ketamine and psychedelics, which is a good match for ketamine-assisted and psychedelic-assisted therapies where you take the relevant drug, then explore a trauma or memory that you're "stuck" on, then find that your explorations have "unstuck" you much more than they would have without the drug. Sensory evidence seems to be something something AMPA receptors, so maybe ampakines would also be helpful here, but I don't know of any sufficiently good ones, except maybe ketamine again.
Inline links: encoded in NMDA receptors, 5-HT2A receptors
So this model, where inappropriately narrow sensory evidence channels create a bottleneck that makes it impossible to process sufficiently traumatic memories, ties a lot of things together. It gives me the understanding of the trauma-somatization link that The Body Keeps The Score never quite managed. It helps tie together the mechanisms of action for psychedelics, meditation, and therapy. And it resolves the apparent dichotomy between depression as low confidence and depression as negative prior that's been bothering me for so long. This is the most exciting paper I've read so far this year and an important addition to my understanding of predictive processing and psychiatry in general.
Open Thread 184
August 08, 2021 · Original source
2: A lot of people reading that post overestimated whether psychedelics could help them with their own weird issues. Psychedelics are pretty well-tested (albeit informally) for things like chronic pain. They seem to work okay but not miraculously, kind of like everything else. I don’t think this necessarily means the mechanism doesn’t work - if you chose a random antibiotic and took one dose of it to prevent random sinus problems, that would probably also only work “okay”, since it would mix infective causes with non-infective causes, appropriate antibiotics with inappropriate antibiotics, and a single dose of antibiotic isn’t very effective anyway. I think psychedelics as treatment for things like chronic pain are at the “we should figure out the mechanism” stage and not the “patients can use this as a miracle cure” stage.
psychiatry2 mentions across 2 issues

psychiatry is a recurring concept in the Astral Codex Ten archive, appearing 2 times across 2 issues between May 30, 2023 and July 18, 2024. The archive places it in contexts such as "One of the hardest things in psychiatry is to look at a group of extremely unhealthy people doing some weird thing"; "Once you are in the 'clutches of psychiatry', they don't let you go". It most often appears alongside Access Pass, advanced meditators, Africa.

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psychiatry
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Are Woo Non-Responders Defective?
May 30, 2023 · Original source
One of the hardest things in psychiatry is to look at a group of extremely unhealthy people doing some weird thing, and figure out whether the weird thing is causing their problems vs. a useful coping strategy. Schizophrenics smoke much more often than other people; is this because nicotine causes schizophrenia, or because it controls the symptoms schizophrenia (studies suggest the latter). What about marijuana? (here the studies are unclear, a lot of people think it might contribute). This is hard because you see schizophrenic people using lots of drugs, and you naturally think “man, every schizophrenic I know is a druggie, probably drugs are bad”. This is fair enough if you go on to avoid drugs yourself. But it’s less innocuous if you use it to justify taking the drugs away from the schizophrenic people, on the grounds that it’s perpetuating their condition.
Highlights From The Comments On Mentally Ill Homeless People
July 18, 2024 · Original source
$1 billion/year in projected costs, translated into Californian, means $100 trillion quadrillion/year in actual costs. Of these, I think 3 is the biggest deal. If it’s as hard to commit someone to these institutions as it is to convict them of a crime, then these institutions don’t help much above how much the existence of prison also helps (eg not much). If you invent a new legal maneuver where it’s easier to commit someone than to convict them of a crime, then why do you even need the step where you build the institution? Just invent the legal maneuver and send more people to prison! I think that maybe the thought is that the institution seems more “humane” than prison, and so people will be more willing to allow low-friction legal maneuvers for confining people there. I think this is cope; not only won’t the institutions be more humane than prisons, but people won’t believe they are and won’t allow the low-friction legal maneuvers. Drethelin writes: What if we abolish the DEA and just let anyone buy anti-psychotics over the counter? This would be the FDA we’re abolishing, but otherwise yes, this is the sort of clever outside-the-box thinking that I appreciate from my commenters. Antipsychotics are very cheap (some well-regarded drugs like Abilify and Seroquel cost about ~$10 per month of pills). On the other hand, homeless people have very little money. So if you were going to do this, it would make sense for the government to give them away for free. These drugs have many potentially serious side effects. But it’s not clear how much homeless people’s 5-minute monthly visits with a bored Medicaid doctor does to avert these side effects, over having some kind of pharmacist or advocate or social worker in the free distribution center giving helpful advice. Like everything, I think this would only help around the edges - the fraction of homeless mentally ill people who drugs can help, who are willing to take the drugs, and who are prevented only by cost and bureaucracy. What percent is that? Low confidence guess 25%. DZ writes: I think you’re missing the goal of a short arrest (few days). Part of the problem is the homeless are in areas where society doesn’t want them to be. They’re near city downtowns where tourists spend time or near commercial districts or in otherwise nice parks. If you can arrest them for a few days and keep arresting them until they move somewhere else … the goal is to eventually force them to move to the more acceptable areas vs. least acceptable areas. This is obviously not ideal but in the mean time the city gets more tourism, more office rentals, etc. Europeans ruthlessly arrest homeless people who hang out in the touristy areas. SF doesn’t, yet. I commented that I was worried that “out of touristy areas” means “into residential areas”. And I feel worse making residents deal with this than tourists, and am less confident that the city cares enough about them to fight back. DZ responded: Agreed. People don’t want them in the residential areas or suburbs either and for good reason. But my guess is cities can identify certain areas where they would prefer the tents to set up. Something like industrial areas or run down parks. The key is that city officials should be able to use arrests as a strategy to move the tents/homeless concentrations without having to face a million lawsuits. I don’t know if there are really areas like this, but I welcome learning more from people who know cities better. SMK writes: This probably sounds draconian and cruel, too, but in fairness, all these discussions seem to assume that this person is in San Francisco and can never ever leave for some other, more affordable place. I get it -- it's tough leaving home, and maybe they'd be leaving friends. But they wouldn't be the only people leaving SF over rent prices, and they'd pretty clearly be among the most rational. So I dislike articles like this when they say things like "the average wait time for a homeless shelter bed is 826 days" or "cheap apartments in SF are $1000 / month." I have a friend who was homeless for around a year in another major American city, and he said it was always 100% feasible to get a shelter bed if he wanted one. Indeed, there were several options. On a different note, I also think that if one were going to go a "cruel and draconian" route, homeless shelters might be able to change policies to better support that and prevent some of the issues you highlight. If it takes 826 days to get a shelter bed, then zero of the typical people you mention who are briefly homeless are getting shelter beds. If all of the people who were homeless for longer were either leaving or in jail, then more of those people probably would get beds. Am I saying this is the policy I favor? No, I agree it's a hard problem and I'm not sure what the right answer is. But things like this need to be kept in mind, too. Again, I think it’s helpful to go to the specific policy level. What’s the policy here? Give homeless people brochures reminding them that other cities exist? I’m sure they know this. Give homeless cities free mandatory bus trips to those other cities? What prevents the other cities from giving them free mandatory bus trips back? Even if they don’t, what if the homeless prefer being homeless in San Francisco to having a better situation in a cheaper city? A bus from Phoenix to SF is only $60; even a homeless beggar might be able to scrounge up that much money if they’re motivated. Maybe some plan like making a deal with a big cheap city in Texas to take SF homeless in exchange for money, and as soon as the homeless get off the bus, they’re met by a Texan social worker who gives them a shelter bed and social services? Might help along the edges, but remember that only about half of homeless people want/will accept shelter beds (depending on how good the shelter beds are). Sergei writes: After checking a bit, let me point out the obvious. What works elsewhere is PATERNALISM. Once you are in the "clutches of psychiatry", they don't let you go. Upon release you are placed into some sort of housing, your appointments are monitored and a social worker will find you and drive you there. You will be given multiple chances to get a job and/or rehab. Your meds will be delivered to you if you cannot pick them up. They remind you to take them. There will be a social safety net so you are never in a situation where you end up on the street unless you really really try to. In retrospect, it makes sense: people who are not able to take care of themselves for a time because of a fixable mental infirmity are taken care of by the state, until they can. That's what we do with children already. I continue to want people to provide details. “They don't let you go" - okay, so the person is in a locked facility? Placed in "some kind of housing"? Does the housing have locks on the door, or can they leave? What if they do leave? "Multiple chances to get a job", oh, great, with whom? How are you enforcing that they take mentally ill people? What happens when the mentally ill people are less good workers than other people they could hire, or have some kind of crisis on the job, as even the best-treated person might once in a while? Maybe we can charitably fill in the details. Something like: Ban some combination of camping outside and being visibly mentally ill.
Inline links: writes
Puerto Ricans2 mentions across 2 issues

Puerto Ricans is a recurring concept in the Astral Codex Ten archive, appearing 2 times across 2 issues between May 01, 2024 and July 03, 2025. The archive places it in contexts such as "They combined Mexican-Americans, Cuban-Americans, and Puerto Ricans"; "They combined Mexican-Americans, Cuban-Americans, and Puerto Ricans ... into the new race 'Hispanic'"; ""since 1964, when Mexican-Americans, Cuban-Americans, and Puerto Ricans were the three equally-sized groups"". It most often appears alongside Chinese, #MeToo, #StopAAPIHate.

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Book Review: The Origins Of Woke
May 01, 2024 · Original source
They combined Mexican-Americans, Cuban-Americans, and Puerto Ricans - previously three different groups that had been viewed as “white lite” along the same lines as Italians - into the new race “Hispanic”, adding in all of South and Central America for good measure. Then, under pressure from black activists who were worried that some blacks would reclassify as Hispanics and they’d lose constituents, they declared Hispanics to be an “ethnicity” that you could have along with a different race. So a white Spaniard from Spain and a white Spaniard from Mexico got treated as different ethnicities, but a white Spaniard from Mexico and a Mayan from Mexico got the same ethnicity.
The point about “Hispanics” is better taken, and you can read more about the case here. But since 1964, when Mexican-Americans, Cuban-Americans, and Puerto Ricans were the three equally-sized and equally-interesting groups, the Hispanic community has become dominated by Mexican (and Central American) immigrants, who do form a pretty natural grouping. People are just as happy to talk about Latinos (and Latinx) as Hispanics. I’m not sure we can attribute this one to the government either.
Inline links: you can read more about the case here
Highlights From The Comments On Missing Heritability
July 03, 2025 · Original source
So maybe there’s more of a role here for problems [2] and [3], about the difficulty of applying a score trained on Europeans to non-European populations? My question there is - shouldn’t this produce nonsense results, rather than results which reflect the populations’ real-world IQs? I think the counterargument here would have to be that by coincidence or colonialism, the populations with the furthest genetic difference from Europeans also happen to have the lowest real-world IQs (for social reasons) - or at least that this trend holds in a vague enough way to produce the vague correlation seen on the graph. There’s some evidence for this - this Piffer’s application of EA4 predicts that Chinese (real average IQ 105) have the same educational attainment as Puerto Ricans (real average IQ 82). So maybe it’s just showing average genetic distance from its European sample after all, and Chinese and Puerto Ricans are about equally distant on average? This wouldn’t explain why the predictor correctly finds that Ashkenazi Jews come out highest, but that could be because their “European” sample did include Ashkenazi Jews, and so here problem [1] does come in.
Pulitzer2 mentions across 2 issues

Pulitzer is a recurring concept in the Astral Codex Ten archive, appearing 2 times across 2 issues between July 08, 2022 and January 17, 2025. The archive places it in contexts such as "It won a Pulitzer"; "Pulitzer-quality book". It most often appears alongside Berkeley, 1968 convention, 1976 Democratic.

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Pulitzer
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January 17, 2025
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Your Book Review: The Outlier
July 08, 2022 · Original source
But I wondered what, if any, hidden depths lay within the peanut farmer. Also, I wanted to enter this contest, and I didn’t want to pick a book that I thought a bunch of other people might also review. So I turned to The Outlier: The Unfinished Presidency of Jimmy Carter, by Kai Bird. Like Carter, this book seems to have been largely forgotten. It won a Pulitzer, but I had never heard of it until I googled “best book about Jimmy Carter.” It seems to have gotten a lot less attention than similar recent biographies about Grant, Roosevelt, and Truman, and it’s hard to imagine it ever becoming a TV show or a musical.
Inline links: The Outlier: The Unfinished Presidency of Jimmy Carter
Links For January 2025
January 17, 2025 · Original source
I agree with this solution. 3: Ruxandra Teslo and Willy Chertman: The Case For Clinical Trial Abundance 4: This month in nominative determinism: NYT article calculating your chance of winning the lottery, by Victor Mather (h/t Yafah Edelman). 5: Someone is working on a dating site that uses your conversations with Claude to find a match. Link here, although so far it’s just a landing page where you can register interest (h/t @venturetwins) 6: The Lyttle Lytton Contest searches for the worst possible opening line for a novel; it’s been going on since 2001 and this year’s results are in. 7: Gary Marcus and Miles Brundage have made a bet about AI progress. I agree with @tamaybes and others in saying that Miles let Gary off too easily; Gary’s public statements all sound like “modern AI is mostly hype, it doesn’t really do anything like thinking”, but the bet is about things like “will AI make a Nobel Prize caliber scientific discovery by 2027?” and “will AI write Pulitzer-quality books by 2027?” I don’t blame Gary for taking the best terms he could find. But I am worried that if AI makes a Nobel-quality scientific discovery in 2026, but doesn’t quite write the Pulitzer-quality book, then Gary will get to claim victory over the AI optimists, whereas in fact that would be at probably the 95th percentile of fast timelines by most people’s estimate. 8: “The probability that cows (or other non-human animals) are experiencing constant bliss, lack tanha (craving, aversion, and the resulting suffering), or are "enlightened by default" is, by my estimation, very low”. 9: Recursive Adaptation (blog on addiction policy)’s predictions for 2025. 75% of FDA approval of GLP-1 for a substance use disorder by 2029! 10: In my post on the economics of GLP-1 receptor agonists (eg Ozempic), I wrote about how they’re currently widely available because of a loophole suspending patents during a shortage, and predicted there would be a big fight when the shortage was over. Sure enough, the FDA tried to declare that the shortage of tirzepatide (a next-generation Ozempic relative) was over, compounding pharmacies sued, and tirzepatide is still available while the issue goes through the courts (and will the administration have an opinion?) Also, compounding pharmacy access startup Mochi says that they will continue to prescribe even if the shortage is over, using another loophole saying doctors can do this for specific individual patients in cases of medical necessity. This is an extremely fake use of this loophole, but will the government be willing to call their bluff? 11: Jacob Falkovich has a blog on dating advice, which he plans to turn into a book of dating advice. I can’t really comment on the accuracy (my dating strategy tends to look more like waiting for women to send me emails saying “I like your blog, would you like to go on a date?” which probably doesn’t generalize), but I’ve had many good interactions with Jake, and he has a beautiful family which means he must be doing something right. Also, Jake is poly, and I sometimes wonder if poly people are the only ones qualified to give dating advice: if you’re monogamous, you either met your future spouse quickly (in which case you have no experience), dated for years without meeting your spouse (in which case you can’t be very good), or aren’t looking for a committed relationship at all (which is just pickup artistry, and follows very different dynamics). Poly people are the only ones who can break out of this trilemma! 12: Christ And Counterfactuals is a blog on effective altruism from a Christian perspective. Some previous attempts at this have felt kind of forced, but the first post I read here was actually pretty interesting. Richard Swinburne (apparently “the world’s best Christian philosopher”), thinks that: “[One] reason why it is good that the human race should sometimes be in an initial situation of considerable ignorance about the causes and effects of our actions, is this. If God abolished the need for rational inquiry and gave us from childhood strong true beliefs about the causes of things, that would make it too easy for us to make moral decisions. As things are in the actual world, most moral decisions are decisions taken in uncertainty about the consequences of our actions. I do not know for certain that if I smoke, I will get cancer; or that if I do not give money to some charity, people will starve. So we have to make our moral decisions on the basis of how probable it is that our actions will have various outcomes—how probable it is that I will get cancer if I continue to smoke (when I would not otherwise get cancer), or that someone will starve if I do not give. Since probabilities are so hard to assess, it is all too easy to persuade yourself that it is worth taking the chance that no harm will result from the less demanding decision (the decision which you have a strong desire to make). And even if you face up to a correct assessment of the probabilities, true dedication to the good is shown by doing the act which, although it is probably the best action, may have no good consequences at all.” (Could a Good God Permit so Much Suffering? A Debate, pp. 52-53.) This is pretty galaxy-brained, but something galaxy-brained must be going on for God to tolerate the existence of evil at all, and this is a surprisingly natural extension of some common premises on the subject. 13: Swedish study: diagnosing the marginal patient with a psychiatric condition makes their life worse. Of the two mechanisms they looked at, stigma seems more involved than drug side effects. My opinion: this study was done on conscripts undergoing a mandatory psych evaluation for the army, who had no previous reason to think they had a psych disease and had not sought treatment. This is a different situation from somebody who comes to a psychiatrist asking for relief from specific symptoms they have noticed. Also, Sweden c. 2005 is a different culture from America 2025 in terms of how much stigma a psych diagnosis carries. I think it’s possible that if you never considered that you had psychiatric problems, and were suddenly given a diagnosis in 2005 Sweden and told you couldn’t serve in the army, that’s likely to destabilize your self-image more than a person who knows they’re depressed going to a psychiatrist in 2025 US and getting antidepressants. 14: RIP Felix Hill, research scientist at DeepMind and mentor to many in the AI community. You can read his suicide note here, though the obvious content warning applies. He says he took ketamine for mild anxiety and it plunged him into an incredibly deep depression that he couldn’t get out of; he leaves his story behind as a warning for others. I appreciate his warning, but I wish he had said more about what dose he used; different people’s ketamine doses vary by almost two orders of magnitude, I’d previously thought that the low doses were pretty safe and the high doses were sketchy, and I would like to know whether I should update or not. 15: RIP Max Chiswick, professional poker player, effective altruist, and ACX reader. 16: Adrian Dittman, a Twitter account widely accused of being Elon Musk’s alt, has been revealed to be . . . a guy named Adrian Dittman. Congrats to Maia Crimew and the Spectator for actually investigating this, unlike many other news sources which spread the Musk conspiracy theory. Also, the people involved got banned from X for some reason, maybe because this qualified as doxxing Dittman. 17: Related: Musk claims to be among the top players in the world at several computer games. A veteran Path of Exile gamer presents evidence that Musk faked his PoE2 accomplishments by hiring a Chinese guy to play on his account. Some Musk supporters in the comments suggest that maybe he hires the Chinese guy to level up his account, but his accomplishments (eg speedruns) are still his own? 18: Related: Sam Harris says he has been friends with Musk since 2008, but he noticed a sudden shift for the worse in his personality around 2020 which made it impossible to stay friends with him. He gives the example of Musk losing a bet with him that there would be 35,000+ COVID cases in the US, refusing to pay up, and launching personal attacks on Sam when asked to do so. What happened? Some theories: Musk turned right-wing, which ended his friendship with Sam for the same reason political differences have always ended friendships (but then what about the bet, which seems like objectively bad behavior?)
Inline links: this, The Case For Clinical Trial Abundance, NYT article calculating your chance of winning the lottery, here, @venturetwins, this year’s results are in, Gary Marcus and Miles Brundage have made a bet about AI progress, @tamaybes, by my estimation, Recursive Adaptation, my post on, the FDA tried to declare, will continue to prescribe, a blog on dating advice, Christ And Counterfactuals, the first post I read here, diagnosing the marginal patient with a psychiatric condition makes their life worse, RIP, here, RIP, a guy named Adrian Dittman, got banned from X for some reason, presents evidence
Pyramid2 mentions across 2 issues

Pyramid is a recurring concept in the Astral Codex Ten archive, appearing 2 times across 2 issues between January 13, 2023 and March 03, 2023. The archive places it in contexts such as "Maybe these people are more akin to the Kennedy and Pyramid believers in Part 1?"; "part of the Pyramid above the water". It most often appears alongside 1700s Great Britain, Acropolis of Athens, Against The Grain.

Article page
Pyramid
Mention count
2
Issue count
2
First seen
January 13, 2023
Last seen
March 03, 2023
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Conspiracies of Cognition, Conspiracies Of Emotion
January 13, 2023 · Original source
Some conspiracy theories center on finding anomalies in a narrative. For example, Oswald couldn’t have shot Kennedy, because the bullet came from the wrong direction. Or: the Egyptians couldn’t have built the Pyramids, because they required XYZ advanced technology. I like these because they feel straightforwardly about styles of processing evidence
Consider the pseudohistory claims I discuss in The Pyramid And The Garden. The Great Pyramid’s latitude in standard notation equals, to within seven decimal places, the speed of light in tens of millions of meters per second. In a strict sense, this is a one-in-a-million chance, although the post tries to explain why this might be less impressive than it sounds.
Inline links: The Pyramid And The Garden
So the evidence in favor of “aliens who knew the speed of light built the Great Pyramid” is that it would explain this otherwise baffling coincidence. The evidence against is everything else we know about history, archaeology, architecture, and common sense. Why would superadvanced aliens have visited Earth, created one primitive stone structure, and left without doing anything else? Why does the Great Pyramid look so much like other Egyptian pyramids, and fit into our narrative of Egyptian history so well? What about marks on the Great Pyramid suggesting it was made with primitive tools? Et cetera.
Against Ice Age Civilizations
March 03, 2023 · Original source
The top 80m of the Great Pyramid would rise above the waterline, forming a little island. The part of the Pyramid above the water would still be taller than the entire Leaning Tower of Pisa. It would be pretty hard to miss!
0.5% chance we ever find something demonstrating equal or greater architectural advancement to the Great Pyramid, dating from before 11,000 BC.
P = NP1 mentions across 1 issues

P = NP is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between August 26, 2025 and August 26, 2025. The archive places it in contexts such as "Used car dealers with proofs of P = NP". It most often appears alongside 4chan, ACX Grants, AI.

Reference entry
P = NP
Mention count
1
Issue count
1
First seen
August 26, 2025
Last seen
August 26, 2025
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In Search Of AI Psychosis
August 26, 2025 · Original source
I think now there might be several dozen subreddit moderators who could accurately describe their job as “witch webmaster who runs an online service giving advice to new witches”. And partly it was because there are so many crazy beliefs in the world - spirits, crystal healing, moon landing denial, esoteric Hitlerism, whichever religions you don’t believe in - that psychiatrists have instituted a blanket exemption for any widely held idea. If you think you’re being attacked by demons, you’re delusional, unless you’re from some culture where lots of people get attacked by demons, in which case it’s a religion and you’re fine. This is partly political self-protection - no psychiatrist wants to be the guy who commits an Afro-Caribbean person for believing in voodoo. But it also seems to track something useful about reality. Nietzsche wrote “Madness is something rare in individuals — but in groups, parties, peoples, and ages, it is the rule.” Most people don’t have world-models - they believe what their friends believe, or what has good epistemic vibes. In a large group, weird ideas can ricochet from person to person and get established even in healthy brains. In an Afro-Caribbean culture where all your friends get attacked by demons at voodoo church every Sunday, a belief in demon attacks can co-exist with otherwise being a totally functional individual. So is QAnon a religion? Awkward question, but it’s non-psychotic by definition. Still, it’s interesting, isn’t it? If social media makes a thousand people believe the same crazy thing, it’s not psychotic. If LLMs make a thousand people each believe a different crazy thing, that is psychotic. Is this a meaningful difference, or an accounting convention? Also, what if a thousand people believe something, but it’s you and your 999 ChatGPT instances? III. A Hidden Army Of Crackpots I have a family member who believes that the theory of evolution, as usually understood, cannot possibly work. He has developed an alternative theory called “noctogenesis” which patches Darwinism using ideas from the transactional interpretation of quantum mechanics, and he works on-and-off on various related books and papers. I have told him I suspect he might be a crackpot; he stands by his claims. It’s fine; when I got into the technological singularity and AI safety, lots of people suspected I was a crackpot, and I stood by my claims too. You’ve got to stand by your family members even when they’re slightly crackpottish. This family member is happily married, retired after running a successful business, and generally a normal likeable person. He has no signs of mental illness, and doesn’t talk about quantum evolution unless someone else brings it up first. There must be millions of people like him. Used car dealers with proofs of P = NP, dentists who think they’ve discovered something important about Mary Magdalene, math professors obsessed with destroying the moon. I’m working on evaluating ACX Grants, and these people are out in force. A few propose literal perpetual motion machines. Others have vaguer plans, like some kind of social media app (it’s always a social media app) that will cause world peace. Many of them have decent jobs and seem like upstanding members of society. Their secrets are known only to themselves, their family members, and their would-be grantmaker. …and, increasingly, their chatbots. After years of hiatus (or at least not talking to me about his work) my family member is back on the quantum evolution beat, and LLMs appear to be involved. If I knew him less well, I would think the LLM had caused the quantum evolution theory - but no, it just made it much easier to research and write about. Is this psychosis? The answer has to be no, but it’s once again hard to draw the line. A very small number of crackpots will be vindicated by history. A larger number will be erroneous but sympathetic - the official account of the Kennedy assassination is pretty weird, and reasonable minds can disagree. From there, we get to ones that are maybe not so sympathetic: flat earth, QAnon, the thing where the Queen was an alien lizard. If only one person thought the Queen was an alien lizard, and they never managed to convince anyone else, would that be sufficient evidence for a delusional disorder? I’m not sure. (psychiatry has a diagnosis, schizotypal personality, which sort of involves being a normal person with a few odd ideas, but it’s not a great match for many of these people, and interesting mainly as a genetic curiosity - it travels in the same families as schizophrenia itself) Maybe this is another place where we are forced to admit a spectrum model of psychiatric disorders - there is an unbroken continuum from mildly sad to suicidally depressed, from social drinking to raging alcoholism, and from eccentric to floridly psychotic. People who are eccentric can remain so their whole lives, with the level of expression depending on their social connections and the ease of pursuing their rabbit holes. LLMs, by making it easier to pursue odd theories and serving as a surrogate social connection who always agrees with you, can bring latent crackpottery into the open. IV. Cause And Effect Bipolar disorder has an interesting relationship with sleep. Most manic people sleep very little, or not at all - maybe an hour or two a night. But also, poor sleep can cause bipolar episodes in people prone to them. In a typical case, a bipolar who’s been well-controlled for years will get assigned a big report at work and get poor sleep for a few nights until they finish. At first, this will be just as bad as it sounds, and they’ll be working through a fog of tiredness. Then the tiredness will lift. They’ll feel normal, then better-than-normal, until finally they can’t sleep even if they want to. Then they’ll email the report to their boss and it will be written entirely in Assyrian cuneiform. I increasingly think this isn’t just an incidental feature of bipolar, but part of the reason it exists as a diagnostic category at all. Most people have a compensatory reaction to insomnia - missing one night of sleep makes you more tired the next. A small number of people have the reverse, a spiralling reaction where missing one night of sleep makes you less tired the next. Solve for the equilibrium and you reach a stable attractor point where you never sleep at all. But this does other bad things to your brain - hence the cuneiform. I’m not claiming that bipolar is “just” sleep loss. As Borsboom et al will tell you, psychiatric disorders can be viewed as complex networks of symptoms, each reinforcing the others. In a few pure cases, you can get a ratchet going with sleep alone, and the sleeplessness will spark everything else. More likely, there will be lots of interactions between poor sleep and everything else, and the “everything else” can sink or hypercharge an impending manic episode. Still, I find this a fruitful way to think about bipolar. Sleeplessness is both the cause and the effect. Can delusions also be like this? That is, suppose there’s some personality trait where having one delusion makes you even more delusional. Maybe the delusion makes you excited (who wouldn’t be excited to learn they’re the Messiah?), and you’re more delusional when you’re in an excited state and not thinking clearly. Or maybe it’s a three-symptom cycle - the delusion causes excitement, which makes you unable to sleep, which scrambles your thinking, which makes you more delusional (which makes you even less able to sleep, etc). The point is: delusions are certainly an effect of bipolar disorder. And in the dynamical system model of psychiatric disorders, we should expect that effects are often also causes; that’s how the vicious cycle gets going. This is the best I can do at modeling true LLM psychosis. Someone with a trait where delusions lead inevitably to more delusions starts using an LLM. The LLM accentuates whatever usual tendency towards crackpottery they have and makes them believe something a little crazier than whatever they believed before. Then that crazy belief feeds upon itself and causes other things like excitement and sleep loss, which (if the person is predisposed) precipitates a true psychotic episode. V. Folie A Deux Ex Machina If one person believes a crazy thing, it’s a delusion; if a thousand people believe it, it’s a religion. What if exactly two people believe it? In psychiatry, this is called folie a deux. It fits awkwardly into our nosology and is rarely seen. Still, it happens enough to generate a few case studies. In a typical case, one person has psychosis for some normal reason, like schizophrenia or bipolar, and the second person is a shut-in who lives with them and rarely talks to anyone else. The psychotic person gets some normal psychotic delusion - they’re God, the Feds are after them, etc - and sort of psychically steamrolls over the second person until they believe it too. Usually removing the second person from the first is sufficient for a cure. This slightly challenges the view of psychosis as a biological disorder - but only slightly. Again, think of most people as lacking world-models, but being moored to reality by some vague sense of social consensus. If your social life is limited to one person, and that person themselves becomes unmoored, then sometimes you will follow along. I would expect second-sufferers to believe delusions in a sort of cognitively normal way, the same way people believe true facts, honest mistakes, and conspiracy theories. I would expect them to be less likely (though not zero likely) to have other psychotic features like sleep disturbances, hallucinations, disorganized speech, or a tendency to autonomously generate delusional ideas aside from the one they absorbed from the index case. An introverted person using an LLM has some similarities to folie a deux. If they use the chatbot very often, it might be a large majority of their social interactions. Here the primary vs. secondary distinction breaks down - the most likely scenario is that the human first suggested the crazy idea, the machine reflected it back slightly stronger, and it kept ricocheting back and forth, gaining confidence with each iteration, until both were totally convinced. Compare this to normal social interactions, where if someone expresses a crazy idea that isn’t common in their culture, other people will shoot them down or at the very least nod politely and stop the conversation. So my working theory of LLM psychosis is: Some patients were already psychotic, and LLMs just help them be psychotic more effectively.
Inline links: the transactional interpretation of quantum mechanics, math professors obsessed with destroying the moon, ACX Grants, a spectrum model of psychiatric disorders, As Borsboom et al will tell you, the dynamical system model of psychiatric disorders, folie a deux
p-hacking1 mentions across 1 issues

p-hacking is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between June 18, 2025 and June 18, 2025. The archive places it in contexts such as "Importance Hacking as a problem that is at as important as p-hacking (which is widely regarded as the cause of the replication crises)". It most often appears alongside 1DaySooner, Aatu Koskensilta, acanthamoeba keratitis.

Reference entry
p-hacking
Mention count
1
Issue count
1
First seen
June 18, 2025
Last seen
June 18, 2025
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ACX Grants 1-3 Year Updates
June 18, 2025 · Original source
(1) Importance Hacking We believe that "Importance Hacking" is the next frontier for improving social science. This is a term we coined to describe something we observed again and again in our replications, whereby studies with little to no value get published in top journals due to the use of strategies that lead reviewers to misinterpret the work. More precisely, Importance Hacking occurs when a researcher gets a result that is actually not interesting, not important, and not valuable, but writes about it in such a way that reviewers are convinced it is interesting, important, and/or valuable so that it gets published. Despite it not having a name until we coined one for it (though it's related to some more general terms like "hype"), in our survey of academic psychologists, they rated Importance Hacking as a problem that is at as important as p-hacking (which is widely regarded as the cause of the replication crises) by one measure, and even MORE important than p-hacking by a second measure. In our replication work, we also have found that Importance Hacking is a bigger problem now than p-hacking (whereas we believe that 15 years ago we would have found p-hacking to be far more common than we're finding now). For more about Importance Hacking, see: https://www.clearerthinking.org/post/importance-hacking-a-major-yet-rarely-discussed-problem-in-science
Inline links: https://www.clearerthinking.org/post/importance-hacking-a-major-yet-rarely-discussed-problem-in-science
p-zombies1 mentions across 1 issues

p-zombies is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between June 10, 2025 and June 10, 2025. The archive places it in contexts such as "the p-zombies’ speech is produced by a part with access to high-level processing". It most often appears alongside brain, Chalmers, conscious.

Reference entry
p-zombies
Mention count
1
Issue count
1
First seen
June 10, 2025
Last seen
June 10, 2025
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P-Zombies Would Report Qualia
June 10, 2025 · Original source
There’s a long-running philosophical argument about the conceivability of otherwise-normal people who are not conscious, aka “philosophical zombies”. This has spawned a shorter-running (only fifteen years!) rationalist sub-argument on the topic. The last time I checked its status was this post, which says:
Inline links: “philosophical zombies”, this post
Start by imagining a race of p-zombies who are exactly like humans, except for two things. First, they don’t have conscious experience. Second, they don’t necessarily report having conscious experience; if we want to claim that they do, we’ll have to derive this fact from first principles.
These p-zombies talk to each other (like humans do), and an outside observer might notice that they report on some levels of mental processing, but not others (like humans do). For example, they might fail the infamous PARIS IN THE THE SPRINGTIME test, reporting only one THE rather than two. The observer would conjecture that the p-zombies’ speech is produced by a part with access to high-level processing (after the Paris sentence has been rounded off to its more plausible alternative), but not low-level processing (the base-level sense-data including both “the”s). Thus, the observer would reinvent the idea of the “conscious” vs. “unconscious” mind. This isn’t surprising or a contradiction of our premise - this is a different sort of “conscious” (easy problem) than the one we agreed the p-zombies lack (hard problem). But it will be linguistically awkward, so let’s call this distinction the “reportable” vs. “unreportable” mind.
Inline links: PARIS IN THE THE SPRINGTIME, hard problem
P. gingivalis1 mentions across 1 issues

P. gingivalis is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between August 14, 2025 and August 14, 2025. The archive places it in contexts such as "periodontitis bacteria P. gingivalis". It most often appears alongside A. Bejanin, A. de Calignon, A. Elobeid.

Reference entry
P. gingivalis
Mention count
1
Issue count
1
First seen
August 14, 2025
Last seen
August 14, 2025
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In Defense Of The Amyloid Hypothesis
August 14, 2025 · Original source
Another competitor is the microbial infection hypothesis. Again, there is good evidence this is true in some cases - multiple pathogens such as the periodontitis bacteria P. gingivalis [118] and various herpes viruses [3, 119] are correlated with the disease, which has tempted some microbiologists to treat amyloid as merely a harmless correlate: since amyloid is involved in the body’s immune response, maybe in the process of causing brain damage the microbes cause some amyloid deposition on the side. But again, these facts are also consistent with the ATN (or in this case IATN - infection → amyloid → tau → neurodegeneration) hypothesis.
P.C.1 mentions across 1 issues

P.C. is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between April 22, 2022 and April 22, 2022. The archive places it in contexts such as "lots of initials (eg PC, LA, etc), get used in common speech". It most often appears alongside A.J., Bee, C.J..

Reference entry
P.C.
Mention count
1
Issue count
1
First seen
April 22, 2022
Last seen
April 22, 2022
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Initial Conditions
April 22, 2022 · Original source
Maybe there’s something linguistically satisfying about JD and CJ that seemingly similar sounds like KP and DA don’t have. But it doesn’t sound that way. And lots of initials (eg PC, LA, etc), get used in common speech, in a way that suggests we’re not having any trouble producing them.
Pact1 mentions across 1 issues

Pact is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between July 01, 2022 and July 01, 2022. The archive places it in contexts such as "leads right back to the Pact, and the history of the outlawry movement". It most often appears alongside 1793, 1821, 1847.

Reference entry
Pact
Mention count
1
Issue count
1
First seen
July 01, 2022
Last seen
July 01, 2022
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Your Book Review: The Internationalists
July 01, 2022 · Original source
In The Internationalists, Oona Hathaway and Scott Shapiro (H&S from now on) work to raise the profile of the 1928 Kellogg-Briand Peace Pact, at the time the most-ratified treaty in history, in which 63 nations (unlike today, this was most of the world - 51 became founding members of the United Nations) came together to declare war illegal. Here is the Pact, in full.
Inline links: The Internationalists
I'll sum up the most common historical view of the Peace Pact with this quote from the US State Department's history website:
Inline links: US State Department's history website
If you find that question confusing, you might, with a little poking at it, start to also wonder why the death of an Austro-Hungarian Prince, in Serbia, at the hands of an anarchist, caused Germany and the US to battle each other in World War I, and when Germany lost, for the allies to humble and punish Germany above all. And that question can lead back to the question of what changed, between World War I, and now, and that, according to H&S, leads right back to the Pact, and the history of the outlawry movement.
pagans1 mentions across 1 issues

pagans is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between October 28, 2022 and October 28, 2022. The archive places it in contexts such as "Witches are worse than pagans, because pagans never knew about Christianity". It most often appears alongside 15th century, Adam, Almighty God.

Reference entry
pagans
Mention count
1
Issue count
1
First seen
October 28, 2022
Last seen
October 28, 2022
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Book Review: Malleus Maleficarum
October 28, 2022 · Original source
Did you know: the German name for Malleus Maleficarum is “Der Hexenhammer” His arguments ring hollow to modern ears, and honestly neither God nor the Devil comes out looking very good. God isn’t trying to maximize a 21st century utilitarian view of the Good, He’s trying to maximize His own glory. Allowing some evil helps with this, because then He can justly punish it (and being just is glorious) or mercifully forgive it (and being merciful is also glorious). But, if God let the Devil kill everyone in the world, then there would be no one left to praise God’s glory, plus people might falsely think God couldn’t have stopped the Devil if He’d wanted to. So the glory-maximizing option is to give the Devil some power, but not too much. Meanwhile, the Devil isn’t trying to maximize 21st century utilitarian evil. He’s trying to turn souls away from God. So although he could curse people directly, what he actually wants is for humans to sell their soul to him in exchange for curse powers. So whenever possible he prefers to act through witches. The rest of this part is just corollaries of these basic points. But there sure are a lot of corollaries, like: Question III: Whether Children Can Be Generated By Incubi And Succubi So, we all know that sometimes demons who look like hot men come and have sex with women in the middle of the night. But can these demons make a woman pregnant? It would seem that the answer should be no, because the Bible says God created Man in His own image, which suggests the conception of new humans is pretty holy, which makes it sound kind of blasphemous to suggest demons could do it. On the contrary side, we know that demons can have kids with humans. The Bible says so: Genesis 6 talks about nephilim, children of “the sons of God” by “the daughters of men”. And St. Augustine seems to think all those stories about Greek gods impregnating women were incubus demons. So “it is just as Catholic a view to hold that men may at times be begotten by means of incubi and succubi, as it is contrary to the words of the Saints and even to the tradition of Holy Scripture to maintain the opposite opinion.” Since the incubi cannot produce semen themselves, probably they steal it from some other human, then bring it to the womb of the person they are having sex with. Question VI: Concerning Witches Who Copulate With Devils - Why Is It That Women Are Chiefly Addicted To Evil Superstitions? Why are most witches women? Probably because women are awful: John Chrystotom says . . . what else is woman but a foe to friendship, an unescapable punishment, a necessary evil, a natural temptation, a desirable calamity, a domestic danger, a delectable detriment, an evil of nature, painted with fair colors! Therefore if it be a sin to divorce her when she ought to be kept, it is indeed a necessary torture, for either we commit adultery by divorcing her, or we must endure daily strife. In fact, the word for woman in Latin is femina, which can also have the form feminus, which is literally just fe minus (lesser in faith)! Because women are less faithful, more carnal, and mentally weaker, they are more easily tempted by the Devil, and make up the majority of witches. Question IX: Whether Witches May Work Some Prestidigitory Illusion So That The Male Organ Appears To Be Entirely Removed And Separate From The Body. IE: can witches steal your penis? It would seem that witches can steal your penis. After all, many people claim to have had their penis stolen by witches. The fifteenth-century peasants among whom Kramer went witch-hunting claimed this. And modern people claim it even today. Frank Bures’ The Geography Of Madness is a great book about recent penis-stealing-witch-related panics, which happened until the mid-20th century in Asia and still happen in Africa. For some reason, this is a classic concern across cultures and centuries. But on the contrary side, God created the human body, and charged Man to be fruitful and multiply. So if the Devil could steal people’s penises it would seem that he must be more powerful than God, which is blasphemous. Kramer answers that witches cannot steal men’s penises, but they can cast an illusion that causes it to look and feel like the penis has been stolen. Classic namby-pamby liberal centrist compromise! Question XIV: The Enormity Of Witches Is Considered, And It Is Shown That The Whole Matter Should Be Rightly Set Forth And Declared This is is one of those “more a comment than a question” questions. Kramer suggests that not only is witchcraft a sin, but it is the worst sin. This section (plus the next few) is a list of all the different things witches are worse than, and why. Witches are worse than pagans, because pagans never knew about Christianity. But witches know about it and deliberately reject it. Witches are worse than Jews, because Jews never claimed to be Christian. But witches were once Christian and then renounced the faith. Witches are worse than ordinary heretics, because ordinary heretics only reject some parts of the faith. But witches implicitly reject all of it by supporting the Devil himself. Witches are worse than Adam, because although Adam’s sin had terrible consequences for the human race, this wasn’t really his direct decision. If we limit our consideration to the specific act, Adam just disobeyed God once, but witches are disobeying God all the time. In fact witches are more sinful than the Devil himself (!), and the Devil’s sin “is in many respects small in comparison with the crimes of witches”. For “both sin against God; but [the Devil] against a commanding God, and [witches] against One who dies for us, Whom, as we have said, wicked witches offend above all.” Witches are literally the worst thing in the entire universe. Whatever else you are concerned about, there is no way it is anywhere close to as bad as witches. If you had the faintest idea how bad witches really were, you would be freaking out all the time. You need to stop whatever you were doing before and become some kind of witch-minimizer instead. This ends Part 1, but if you’re interested you might want to look at further questions from this section, including What Is The Source Of The Increase Of Works Of Witchcraft? Whence Comes It That The Practice Of Witchcraft Hath So Notably Increased?
Inline links: The Geography Of Madness, need to, What Is The Source Of The Increase Of Works Of Witchcraft? Whence Comes It That The Practice Of Witchcraft Hath So Notably Increased?
PageRank1 mentions across 1 issues

PageRank is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between February 02, 2026 and February 02, 2026. The archive places it in contexts such as "I would have said something like PageRank". It most often appears alongside 4chan, Accelerando, Adele Lopez.

Reference entry
PageRank
Mention count
1
Issue count
1
First seen
February 02, 2026
Last seen
February 02, 2026
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Moltbook: After The First Weekend
February 02, 2026 · Original source
Here Eudaemon_0 is complaining about internal site dynamics (note the internal coherence advantage over most users, plus the continued ikhlas vs. riya obsession), and a commenter brings up an interesting comment-quality-enforcement mechanism. They describe it as like a prediction market, which isn’t a terrible analogy, although I would have said something like PageRank. I think Less Wrong does something like this and it works well.
PAIN1 mentions across 1 issues

PAIN is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between November 24, 2021 and November 24, 2021. The archive places it in contexts such as "curcumin is a PAIN (pan-assay interference compound)". It most often appears alongside Alexandros Marinos, Algernon’s Law, COVID.

Reference entry
PAIN
Mention count
1
Issue count
1
First seen
November 24, 2021
Last seen
November 24, 2021
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Pascalian Medicine
November 24, 2021 · Original source
I’m going to guess it’s not true, because I’ve become pretty critical of these people’s methodology since doing the ivermectin review. Also, curcumin is a PAIN (pan-assay interference compound, ie a substance with weird chemical properties that make every test seem positive, so if you do chemical tests to see whether it activates eg coronavirus-fighting immune cells, it will always say yes). This means people are always publishing exciting papers about it and alternative medicine people are always getting really enthusiastic about it and suggesting it as the cure for everything (eg depression).
Inline links: pan-assay interference compound, depression
pain asymbolia1 mentions across 1 issues

pain asymbolia is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between May 15, 2024 and May 15, 2024. The archive places it in contexts such as "in between pain insensitivity and pain asymbolia". It most often appears alongside @the_megabase, A Pan-Species Welfare State, ACX Grantees.

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pain asymbolia
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May 15, 2024
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May 15, 2024
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Profile: The Far Out Initiative
May 15, 2024 · Original source
The “less pain” category includes people who say they've never felt pain at all. There's a genetic condition called congenital insensitivity to pain; patients are incapable of hurting. Most of the “purest” cases die tragically during childhood; in a typical story, they rest their hand on a hot stove, fail to notice, and burn to death. The ones who survive usually turn out to have something in between pain insensitivity and pain asymbolia, where they can notice pain but it doesn’t feel particularly unpleasant. This can still be dangerous - imagine having to argue a young child out of putting her hands on stoves - but it’s a bit more survivable, and there are some weird genetic clusters of it here and there. An Italian family with a mutation in ZFHX2 are immune to pain; so are a Pakistani family with a mutation in SCN9A. Some of these syndromes have other weird side effects; the Italian family doesn’t sweat, and the Pakistani family can’t smell.
Inline links: congenital insensitivity to pain, ZFHX2, SCN9A
Pakistani grooming gangs1 mentions across 1 issues

Pakistani grooming gangs is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between January 23, 2025 and January 23, 2025. The archive places it in contexts such as "several organized child sexual assault rings got busted in Britain - but only after the police spent years deliberately ignoring them, because the perpetrators were mostly Pakistani". It most often appears alongside Bedari, Britain, Nietzschean.

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1
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1
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January 23, 2025
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January 23, 2025
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Everyone's A Based Post-Christian Vitalist Until The Grooming Gangs Show Up
January 23, 2025 · Original source
So it was revealing to watch some of these people trip over themselves to say we should invade Britain because of its tolerance for Pakistani grooming gangs.
Pakistanis1 mentions across 1 issues

Pakistanis is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between May 01, 2024 and May 01, 2024. The archive places it in contexts such as "a company that had 10 Pakistanis and 10 Afghans might get classified as 'too white'". It most often appears alongside #MeToo, #StopAAPIHate, #StopAAPIHate.

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Pakistanis
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1
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1
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May 01, 2024
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May 01, 2024
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Book Review: The Origins Of Woke
May 01, 2024 · Original source
They created the concept of “Asian-American” by combining the old category “Oriental” together with Indians, Pakistanis, Thais, etc. Then, under pressure from the Hawaiian delegation, they added Pacific Islanders to create a even more heterogenous and meaningless category of “AAPI” (Asian American or Pacific Islander). Then, under more pressure from Hawaii later, they separated out “Native Hawaiian” again. The result is that Pakistanis, Koreans, and Tongans are the “same race”, but Hawaiians and Samoans are “different races”.
All of this means that (for example) a company that had 10 Pakistanis and 10 Afghans might get classified as “too white” and get sued for failing to hire enough Asian-Americans. But a company that had 20 Pakistanis, or 10 Pakistanis + 10 Koreans, would be fine.
paleo diets1 mentions across 1 issues

paleo diets is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between March 23, 2021 and March 23, 2021. The archive places it in contexts such as "A lot of the time this sort of thing reduces to metaphorical or literal paleo diets - try to return to the environment of evolutionary adaptedness". It most often appears alongside 2008 crisis, A Failure, But Not Of Prediction, Ancient Phoenicia.

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paleo diets
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1
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March 23, 2021
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March 23, 2021
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Book Review: Antifragile
March 23, 2021 · Original source
"Interventionism is a sucker's game" - intervening in a system requires some kind of theory, some kind of model where the positive effects will definitely be better than the side effects - and given how little people know and how bad we are at prediction, this will probably be wrong. But removing things is kind of like a negative intervention, and so probably good. So for example, you're unlikely to find a medicine as helpful as smoking is harmful, so focus on stopping smoking. You're unlikely to find a superfood as helpful as junk food is harmful, so focus on cutting out junk food. You're unlikely to find a new law as helpful as the old laws are harmful, so focus on getting rid of old laws. A lot of the time this sort of thing reduces to metaphorical or literal paleo diets - try to return to the environment of evolutionary adaptedness, before civilization "intervened".
Paleolithic1 mentions across 1 issues

Paleolithic is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between November 25, 2021 and November 25, 2021. The archive places it in contexts such as "lifestyle during the Paleolithic—men hunted large animals"; "lifestyle during the Paleolithic—men hunted large animals such as mammoth for survival". It most often appears alongside Aleksandar Vucic, awanderingmind, Biden.

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Paleolithic
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1
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November 25, 2021
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November 25, 2021
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Links For November
November 25, 2021 · Original source
Boris Johnson (left) is 5’9, so the guy in the middle must be gigantic. Who is he? Looks like it’s Milo Djukanovic, President of Montenegro, who’s 6’6 (198 cm). Is he the tallest world leader? It seems like he’s tied with his colleague across the border, Serbian president Aleksandar Vucic. Why are Balkan leaders so tall? As usual, the answer is “genetics”. This article says: It has been noted that men from Herzegovina are taller on average than men in other places—the average male height is just over six feet...Putting all the data together, researchers concluded that the most likely cause of larger-than-average height of Herzegovinian men is lifestyle during the Paleolithic—men hunted large animals such as mammoth for survival—such a diet, heavy in protein, combined with small population densities, would have provided ideal conditions for height selection, resulting in increasingly taller men who passed the trait down through their I-M170 chromosome to future generations. Some sources note that they manage to beat the Dutch despite the latter country’s much higher human development index. The Dutch are probably tall through a combination of nature and nurture; Balkan people are tall through nature alone. 7: Eliezer Yudkowsky doesn’t need more ego boosts, but an idea he had a couple of years ago - using strings of bright lights to provide a better and brighter experience for Seasonal Affective Disorder sufferers than regular light boxes - spread from him to the rationalist community to the wider world, and has finally gotten tested in a formal study (see Acknowledgments section). Results seem vaguely positive: "SAD symptoms of both groups improved similarly and considerably...exploratory analyses indicate that a higher illuminance is associated with a larger symptom improvement in the BROAD light therapy group" 8: Percent of people who choose woke options on polls very tentatively and preliminarily seems to be going down post-Trump (h/t Richard Hanania). 9: Twitter conspiracy theories 10: Did you know: all those reconstructions of “how classical art would have looked with the original paint” are probably inaccurate. There is no reason to think the Greeks and Romans used garish technicolor hues on their statues; what evidence we have suggest they were good at shading, and the statues were probably colored very tastefully. 11: Complaints about how Karl Friston uses the term “Markov blanket” 12: Trevor Klee on the claim that cyclosporine patients don’t get dementia. Apparently there was a big study where basically nobody on the immunosuppressant cyclosporine ever got dementia, and there are some theoretical reasons why cyclosporine might prevent neurodegeneration. But another study found people on cyclosporine got dementia at the usual rate. I think in a situation like this you should have a really high prior on “the people who got the crazy result bungled their study somehow”, but I’m interested in hearing what other people think. 13: Also from Trevor: a history of fluvoxamine treatment for COVID. 14: To tide you over until the next book review contest, here is awanderingmind’s review of The Conquest Of Bread. 15: Claims: cnbc.com/2021/11/05/sam…\nft.com/content/dcb75a… (better article, but paywalled)","username":"moskov","name":"Dustin Moskovitz","profile_image_url":"","date":"Fri Nov 05 15:49:46 +0000 2021","photos":[],"quoted_tweet":{},"reply_count":0,"retweet_count":184,"like_count":1188,"impression_count":0,"expanded_url":{"url":"https://www.ft.com/content/dcb75a56-ca23-439c-96db-56483979bf34","image":"https://bucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com/public/images/80a58c96-c72f-4301-b571-aa9384f132bd_2400x1350.jpeg","title":"Subscribe to read | Financial Times","description":"News, analysis and comment from the Financial Times, the worldʼs leading global business publication","domain":"ft.com"},"video_url":null,"belowTheFold":true}" data-component-name="Twitter2ToDOM"> 16: Big trial on Vitamin D for depression finds null result. Peter Attia tries to tear it apart here, but I am unconvinced, especially in the context of Vitamin D never working for any of the things people say it does besides the most boring aspects of bone health. 17: “California is actively considering the adoption of flawed and inequitable guidance on math curricula based on misleading data and inaccurate success metrics reported by San Francisco Unified School District (SFUSD)...Based on our review of the data, we found misleading, unsupported, and cherry-picked assertions of success for the new math program. We noted that overall test scores are down and enrollments in UC-approved advanced math classes have dropped as well.” It looks like San Francisco is trying the good old “lower standards, then when more kids meet the standards, claim your school reform plan worked” trick again. 18: A new study claims that self-reported “Long COVID” symptoms are more associated with believing you’ve had COVID than with actually having it (as measured by serologic testing), which sounds like pretty strong evidence that it’s psychsomatic. Expert reactions are mixed-to-negative, although the only one of these that doesn’t sound like excuse-making is Dr. Rossman’s about the unreliability of the tests. I haven’t confirmed test reliability stats but Philippe Lemoine also thinks this is a plausible confounder. 19: Noahpinion: What If Xi Jinping Just Isn’t That Competent? I appreciated this for making me think, and for underlining the extent of the difference between the Deng/Jiang/Hu era and what Xi’s doing. I especially appreciated this line, which I’d never thought about before: Xi presided over the end of China’s hypergrowth. To some extent this is not his fault. No country can grow at 10% forever, and there were many structural forces pushing downward on China’s numbers — the end of the demographic dividend, the exhaustion of rural surplus labor (the Lewis Turning Point), the saturation of export markets, and so on. But China is also slowing down earlier than South Korea, Taiwan, or Japan did in their day. China’s per capita GDP (at PPP) is still only about 1/3 that of a developed country, so if they stop catching up at about half of developed-country levels, that will not be a great showing. A big lesson of the past twenty years has been “actually liberal democracy isn’t necessary to reach developed-country status”, so it would be quite the twist if it turned out you needed liberal democracy to reach developed-country status. This gets pretty close to the great mystery of why some less-developed countries “catch up” and others don’t; whatever happens in China is going to be a really useful data point. 20: Variations on the fable of The Frog And The Scorpion. 21: You’ve probably heard about the University of Austin, the new project by a bunch of wokeness-critical academics to start a new university that won’t cancel people or force conformity (New York Post article, Politico article - these were the two least “you need to be super-outraged about this right now” articles I could find). Tyler Cowen and Larry Summers are involved; Steven Pinker was supposed to be but left for unclear reasons. My thoughts, in no particular order: Even forgetting the political aspect, attempts to start new universities are always welcome.
Inline links: Milo Djukanovic, Aleksandar Vucic, This article, in a formal study, Richard Hanania, Twitter conspiracy theories, There is no reason to think, Complaints about, cyclosporine patients don’t get dementia, a history of fluvoxamine treatment for COVID, The Conquest Of Bread, Vitamin D for depression, here, is trying, A new study, Expert reactions, Philippe Lemoine also thinks, What If Xi Jinping Just Isn’t That Competent?, Lewis Turning Point, slowing down earlier, per capita GDP (at PPP), the great mystery, Variations on the fable of The Frog And The Scorpion, New York Post article, Politico article
Paleozoic1 mentions across 1 issues

Paleozoic is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between July 14, 2023 and July 14, 2023. The archive places it in contexts such as "simple stories about the Paleozoic". It most often appears alongside !Kung San, aboriginal people on the west coast of Canada, Adam Smith.

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Paleozoic
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1
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July 14, 2023
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July 14, 2023
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Your Book Review: The Educated Mind
July 14, 2023 · Original source
From trivial to rich: the trick What could an intellectually rich elementary school curriculum look like, if we built it on kids’ cognitive strengths? He gives us one suggestion to help us do this: ask where each discipline came from in the first place. What was math before it was math, for example — or science before it was science? Q: How on Earth could that help? That’ll become clear later, when we finally uncover what Egan thinks “education” actually is, and see what job he wants us to give schools. For now, take it as a tantalizing hint… or, y’know, just ignore it. Elementary literature & language What was literature before it was literature? Before people invented writing, they had rich oral traditions: they told simple stories, recited poems, and shared proverbs. Egan suggests that these bits of oral tradition should form the backbone of the elementary literature curriculum. Q: What sorts of stories? As many as we can, and from as many diverse cultures as possible! Folktales are wonderful, as are myths. Think the Aboriginal story of “The Rainbow Serpent”, episodes from the Sumerian “Epic of Gilgamesh”, the Egyptian story of Osiris & Isis, the Greek story of Orpheus & Eurydice, the Chinese Legend of the White Snake, the Japanese Tale of Amaterasu and Susanoo, the Ashanti tales of Anansi, the Aztec myth of Quetzalcoatl, the English legend of King Arthur, the Maori myth of Maui and the Sun, the Roman story of Romulus and Remus, selections from the Indian Mahabharata, the Anglo-Saxon epic of Beowulf, the Inca legend of the Sun and Moon, the Iroquois Myth of the Flying Head (a real thing! look it up!), and the Ojibwe story of Turtle Island. Q: That was a lot of examples. Are you going to keep giving so many? I’ve got a [mumble mumble mumble] to get to. Sorry about that. Sometimes, though, I feel that a limitation of reading Educated Mind is that, in trying to keep his book to a manageable size, Egan skimped on examples in some places that it matters. It’s easy to read his occasional example and assume he intends that it hold some central place in the curriculum — when all he wants to do is display how rich and diverse the curriculum could be. (Also: good God, I didn’t even include an example from Norse mythology!) So from now on, just assume that every category could be filled with oodles of examples. Q: What sorts of poems? Lots of poems, first of all. We shouldn’t steer toward “fancy” poems — rather, we should find poems that appeal to kids immediately — think Shel Silverstein, Mother Goose, Dr. Seuss, Jack Prelutsky, Edward Lear, or Ogden Nash… that sort of thing. In a biting essay, Egan suggests these poets like these appeal to kids precisely because they leverage kids’ cognitive strengths: “we should find, and encourage saying and singing and shouting aloud verse with strong narrative forms, thumping rhymes and rhythms, the most vivid images, fun with metaphors, and a rollicking story.” Q: Why proverbs? Proverbs stick in your mind almost effortlessly. (“All’s fair in love and war!” “When in Rome, do as the Romans do!” “You can’t judge a book by its cover!”) They’re also useful; they capture general truths. Kids can apply them to all sorts of situations, but also discuss them — to what extent are they wise or foolish? (I remember my surprise when I realized that they couldn’t all be true — because you can’t follow “look before you leap” and “he who hesitates is lost” at the same time! I’m embarrassed to say that I think I only realized this when I was in college.) Elementary science What was science before it was science? Egan suggests: being immersed in the natural world. We might, he writes, encourage elementary students to “adopt” some feature of the natural world — a patch of grass, a cat, a branch, a stream — and simply observe it at length. To do this, we can use the cognitive strength of reverie. Q: Oh, do you mean like kids sometimes do in science class nowadays — describe a thing to a partner, make notes, draw it, and label its parts? No, the exact opposite! That’s all about squeezing the experience into words and forms that we understand. What we want “is less an attempt to know about nature as to know it in some participatory way, to know it as something we are an intimate part of, not set off from”. Q: That sounds a little… “woo” to me. It did to me, too… until I remembered my childhood climbing tree. I didn’t much like to go outside as a child, but I had this one tree that I’d climb up and read for hours and hours. If I close my eyes I can bring to mind the precise texture of its bark, the roughness of its broken-off branches, the coolness of its leaves, the always-surprising solidness of its trunk… I’m bigger now, but I think if I were back in my parent’s yard, I could still navigate its limbs with my eyes closed. I have, at this point in my life, read a fair number of books about trees, but I’d be surprised if all of them together more than equaled the amount I learned from that tree — my tree. Elementary math What was math before it was math? Egan suggests: counting and logic. We might, then, use rhythms, metaphors, stories, and jokes to help kids become fond of these. Q: Counting is pretty… basic. Could it really be improved? Beware of “the curse of knowledge”: Steven Pinker’s phrase for forgetting that something was once difficult! Egan suggests we should spend time helping kids count wonderfully. We can start early with counting rhymes. (“One, two, buckle my shoe! Three, four, out the door! Five, six…”) But we can also help kids use their fingers as metaphors. There are some pretty cool ways of using your hands as an abacus — and did you know that you can count up to 1,023 using just your fingers on both hands, and a knowledge of binary? Q: Logic — I’m intrigued! Aristotelian, or Boolean? Neither, for the time being — Piaget was presumably onto something when he found that young children couldn’t reason abstractly, but he was looking at logic in a vacuum. When we put logic into the context of stories, we find that kids can deal with logic just fine. There’s an entire worldwide network of educators, in fact, called Philosophy for Children, who have written whole books about how to do this, and Egan loves it all. Sometimes they read stories and ask simple questions: “What is friendship?” or “What does it mean to be brave?” They also pose ethical questions: “Is it ever right to spill a secret?” And they pose paradoxes: “Can you step in the same river twice?” Q: You mentioned “jokes” a moment ago. Care to elaborate? Egan thinks that, to help kids get good at math, you should tell kids jokes. Q: That’s… new. I think so, too — but he backs it up pretty well. To be funny, jokes (or at least most kid jokes) rely on a leap in logic: Why can’t you trust an atom? They make up everything. Knock-knock. Who’s there? Boo. Boo-hoo? Don’t cry, it’s just a joke! To understand the joke, kids have to follow the logic — spotting patterns, making connections, and tracking what their audience expects a word to mean. That’s a lot of cognitive lifting. And Egan goes further, suggesting that we grit our teeth and create methods to help kids invent their own jokes, no matter how horrible they’ll be at first. (The things we do for learning…) Q: Wait wait wait! What about addition facts, and multiplication tables, and fractions? Egan emphasizes that his methods are designed to be add-ons to the standard math curriculum. In general, he’s a don’t-blow-up-the-system sort of guy, and if something seems especially weird, you should probably assume it’s an add-on to the regular curriculum rather than a replacement, even if I forget to say so. Elementary arts What was art before it was art? Egan suggests we pop our heads into Paleolithic caves for our inspiration. Whatever the specific meaning of all those charcoal elk and aurochs and mammoths (communication with the spirit world? art for art’s sake? a way to impress babes?), Egan thinks it obvious that they were also an attempt to capture an intense experience that would be difficult to express in words alone. What did it feel like to be near an aurochs, or a saber-toothed tiger? “The arts help us,” Egan writes, “to hear and see afresh, to force our perceptions and sensations to experience again the immediacy and vividness of the world”. If we follow this, then, we don’t want to help kids build “art skills” so they can draw like an adult — rather, we want to help them amass a repository of diverse aesthetic feelings that they’ll want to express. We should provide them with a riot of experiences. Q: That couldn’t be more opaque. Examples, please! Egan writes that we should have children learn to whistle, sing, and click their tongue; we should help them emulate the ways a skunk or a hawk or a stick bug might move through a space. We should expose them to scores of different temperatures and materials. In music, we should help them love Beethoven, yes, but also the Beatles; Tchaikovsky, yes, but also Tuvan throat singers, and also John Cage, whale song, and bird song. Q: That’s a lot of experiences, but what would they be doing? An interesting aspect of Egan’s view of education is that he doesn’t seem to think we should push kids right to the “doing” phase. He wants to help kids cultivate an affective relationship with the world. In any case, he writes that as students get more experienced, we should prompt them to move from merely enjoying these experiences to trying to systematically shape similar experiences. And drawing, painting, and playing music could easily be folded into other parts of the curriculum. Elementary social studies What was social studies before it was social studies? Well. Remember how, just a moment ago, I wrote that you could assume that you should probably assume that Kieran isn’t in favor of junking the curriculum as it currently stands? He suggests we very carefully pick up the elementary social studies curriculum, place it into a trash can, and set the whole mess on fire. He isn’t worried about much of importance being lost. (Remember that the “expanding horizons” model is, to him, the original sin of 20th century educational reform, and he repeatedly quotes student surveys showing that “social studies” regularly wins the title of “most boring subject”.) In its place, he suggests we put history — which, he hints, we should think of as the centerpiece of the elementary curriculum. So the real question is what was history before it was history? His answer, surprisingly, is myth. Q: Egan wants us to teach myths as if they were history? Not at all. What he suggests, though, is that we look at how myths operate as narratives — so we can design an intellectually vivid history curriculum. And myths really are special: each is built on at least one binary (like weak vs. strong, or lies vs. truth, or so on), and uses that to tell the story of the big picture of the world. They’re so powerful that people can understand it, remember it, and love it — even if that thing never happened. We should take that power, Egan says, and apply it to things that really did happen. Q: So what history does he think kids should learn in elementary school? The great struggles of humanity from across the whole. Flippin’. World. We’re still talking about young children, so these should be done as simple stories. The goal isn’t to make them history PhD’s, so we needn’t even try to put them in any sort of order. Egan suggests that, in first grade, we pick a single binary like “freedom against oppression” and tell kids a welter of stories, again from as many cultures as possible, and as many times in history as possible. Q: Can you give examples? Oh, all right — in first grade we can tell kids the stories of the war of the Greek city-states against the Persian empire, and the slave uprising of Spartacus against the Romans. We can tell them about the plight of Jews in medieval Europe, and of the unsuccessful Sepoy Rebellion in India against the British. We can tell the stories of the American, French, and Haitian Revolutions, and about the Chinese Taiping Rebellion against the Qing Dynasty. We can tell them the story of the escaped slave Harriet Tubman returning to the South to rescue her kinsmen, the story of six-year-old Ruby Bridges facing threats to integrate her elementary school, and the story of how the Mau-Mau uprising led to modern-day Kenya. We can tell the stories of Mexican-American union organizer Cesar Chavez and of Malala Yousafzai surviving an assassination attempt to advocate for female literacy. The world does not lack for stories of oppression and liberation that can capture the attention of a six-year-old. Q: That’s… huh. What stories might they hear in second and third grade? Egan gives examples, but I won’t list them here. He suggests we use a similar approach for each, except that we swap out the binary each year. He thinks “the struggle for security against danger” would work well for year two, and “the struggle for knowledge against ignorance” would work well for year three. (That year could have a lot of overlap with the science curriculum.) Q: Anything else, for history? Yes — they should get a sense of Big History. They should get some simple stories about the ice age, the Cenozoic, the age of dinosaurs, the Paleozoic, the origins of our solar system, and the Big Bang. (Because if the ancient Norse can tell their story of the beginning of the universe, by gum, we can tell ours, too.) To sum up Egan argues that the problem of early schooling is that it’s trivial — and it’s trivial because the dominant theories of educational psychology see children as lesser versions of adults. What else would we teach them, except dumbed-down versions of what adults learn? But children have certain cognitive strengths that schools aren’t making systematic use of. If we rebuild elementary schools on those strengths, we could turn schooling upside down. We could stop seeing the curriculum as a bag of information to impart, and start seeing it as a set of great stories to tell — and invite kids into. Kids could experience (both intellectually and emotionally) the great struggles of humanity and see that they can join in them. Students could experience the story of education as the beginning of a very real adventure. Egan’s elementary school: some skeptical questions Q: I’m not sure I’m understanding what you mean by “mental images”. Care to explain? It’s an interesting fact of human cognition that just a few words can whip up a complex mental experience. Egan doesn’t just mean what we might call “visual imagery” — the ability to hold, say, the image of a bespectacled, spat-wearing duck in your mind without seeing a photograph. He’s also including what psychologists call auditory imagery, olfactory imagery, gustatory imagery, and tactile imagery. Q: How could all of that be helpful in schools? Humanity has a built-in VR system, and we’re not using it! Egan invites us to pretend we’re teaching a class about the humble earthworm. We might list off facts — “earthworms are so many centimeters long, move through soil by means of their something-or-other muscles…” but he suggests we can evoke images, say, “of what it would be like to slither and push through the soil, hesitantly exploring in one direction then another, looking for easier passages, contracting and expanding our sequence of muscles segment by segment, and sensing moisture, scents, grubs, or whatever”. Those facts are now felt by the student; the knowledge has become part of them. And just a few words can spark a complex mental experience, one going beyond literal images to include imagined sounds, smells, tastes, and more. These experiences can feel real and stick with us. (That these mental images are so easy to evoke, and so meaningfully felt, feels something like the proverbial hundred dollar bill on the ground.) Q: How could metaphors be helpful? It really is interesting that so much of the “constructivist” turn in psychology — that is, the notion that children don’t absorb knowledge, but construct it — has continued to focus on logics-mathematical reasoning, when there’s been mounting evidence for decades that metaphors are more central. It’s not just that we use metaphors to better understand things we already know, we also use them to grasp new knowledge. What’s more, psychologists have devised tests to measure the skill at metaphor-making, and have given them to people of different ages. What they found was that eleven-year-olds make more metaphors (and higher quality metaphors) than do undergraduates — and that four-year-olds have both groups beat. Again, hundred dollar bills on the sidewalk. Q: Your talk of “binaries” has me worried — binaries like good/evil and male/female are the source of so many of our most pernicious stereotypes! Isn’t the purpose of education to get us beyond stuff like this? Yes, it is! Education is supposed to complicate our understanding — but that means we’ve gotta start somewhere, and binaries provide us a natural starting place. As an uncontroversial example, think about temperature. We all begin as babies by perceiving two temperatures — hot and cold. Later, we add on intermediate categories — warm and cool. (Note that the human body is the assumed mid-point to temperature. Binaries often work like this; “big” and “small” mean “bigger or smaller than me”, “nasty” and “kind” mean “nastier or kinder than I am, except when my brother is really asking for it”, and so on.) A good story (and an Egan-inspired elementary curriculum is, in a sense, nothing but good stories) will go further, and transform the binary. Toy Story is grounded in the binary of abandonment/belonging: at the beginning, the toy cowboy Woody belongs to his owner, and has his affection. Then a rival comes who threatens his belonging. In trying to get back to belonging, Woody is entirely lost — and to save the day, he has to come to a deeper understanding of what belonging means. Now, all lessons can’t be Pixar movies. But the good stories (especially in literature and history) will challenge and subvert the binaries they begin with. Q: I see the pattern of Egan drawing from “as many cultures as possible”. Why so many? Is this a political correctness thing? If it helps to think of it as such, then, sure! I don’t think Egan would have had a problem with that. But his ultimate reason for including so much diversity goes deeper. For Egan, including such world-wide diversity isn’t optional, and the answer to why is bound up in his definition of education. (Keep reading.) His answer also insists that we, whenever possible, also include stories from the Bible and Homeric epics (the Iliad and Odyssey). Q: Mmm, stories from the Bible aren’t going to fly in my local school! So be it! Egan doesn’t spend much time obsessing over the practicalities of… His interest is in describing what an ideal education might look like, if it were possible. Every lesson, every classroom, and every school is necessarily a compromise. Q: You make a big deal of poems. But isn’t poetry dead? An interesting contrast can be made to classical education, which also has kids read a lot of poems — they see knowing great poems as one of the marks of an educated person; again, for an academicist, it’s the information that transforms. Egan begs to disagree. Poems are important because they’re a wonderful way to train their cognitive strengths, like rhythm (poems are language fueling by thumping). We want to help kids learn to use this tool better, and a great way to do that is to help them recite poems that they’ve learned by heart. Q: “Learn by heart” — is that code for “memorize”?! It is! Egan is actually quite big on memorization — he points out that all the knowledge in the world can do nothing for a person once they’ve forgotten it. He didn’t, however, appreciate the academicist focus on memorizing without understanding (or at least enjoyment). Q: I’m still worried about the science curriculum, as you’re describing it. Can you allay my fears? Honestly, while I feel there’s something profoundly right to how Egan is describing early experiences of nature, I feel the same way. Note that there’s more science coming in the social studies curriculum. But if that’s still not enough, one could bring down aspects of the middle school science stage. Q: Anything else that Egan suggests we do in elementary school literature and language? He suggests that we help kids learn a second language! This is so obviously true (why do American schools typically wait until kids lose the ability to naturally absorb languages to start teaching languages?) he doesn’t belabor it, though. Q: You had mentioned that Egan’s vision seems more internal-focused. Should we be worried about that? While I strongly suspect that his curriculum would make kids more creative in any way you’d like to measure it, Egan wasn’t particularly interested in “creativity” — he was more about helping kids find the world interesting. I get the sense that he thinks kids will do things with minimal prompting once they’re loaded up with complex internal experiences. Q: I think I’m beginning to understand Egan — is he basically saying “make learning fun”? “Fun”, applied to education, is a dangerous word. Egan worries about the dangers of an emotionally unserious curriculum producing emotionally stunted adults. That doesn’t mean we need to tell students only “serious” stories — only that we treat the world honestly. “Disney-esque sentimentality is the exact emotional equivalent to intellectual contempt”. Q: But aren't some of these stories too dark for children who have themselves experienced oppression and disaster? Egan argues that these stories may be especially helpful to them — they can help them understand their struggles better, and give voice to them. Q: At the very start of this, you promised us “rationality”… but I’m not seeing rationality here! All this talk of “adventure” almost seems to go the opposite direction. What gives? Wait for it. But for a hint right now — Egan is fond of citing his fellow educational theorist Jerome Bruner, who claimed “any subject can be taught effectively in some intellectually honest form to any child at any stage of development”. Bruner was criticized for that; his critics charged that he was ignoring learning differences and socio-economic realities. Egan thinks he was profoundly right. Part 3: A new kind of middle school What’s the matter with middle school? What was middle school like for you? In math, I recall a jumble of barely-related topics. In literature, I remember reading great literature — Frankenstein, Romeo and Juliet — only in their dumbed-down summary formats. In social studies, I remember teachers proclaiming on the first day of class that unlike all of our previous history classes, this class wouldn’t be about names and dates… and then going on to memorize names and dates. And in science, I remember being forced to dissect a frog only to discover that frogs are — you guessed it — made of slimy frog parts. Your mileage may vary, but for a lot of us, middle school feels like getting booted out of the (in retrospect) Eden of elementary school, and like marking time before the serious studying of high school. It feels meaningless. In my favorite of his books, Egan calls so much middle school curricula “human deserts”, noting “we have created a system in which the importance of human emotions for meaning seems barely noticed”. Why so meaningless? If our dominant approaches to educational psychology fundamentally misinterpret younger children, Egan suggests, they basically throw up their hands when faced with pre-teens and teenagers. Mainstream schools begin to introduce vocational training to help lighten the load, and Maria Montessori famously suggests that adolescents should be sent to go run a farm. Egan is sympathetic to those responses, but points out that they don’t do much to lighten the load that the academic curriculum often becomes at this age. This feeling of meaninglessness, he argues, is utterly tragic — it comes just when a hunger for meaning blossoms in adolescents! We can see that hunger for meaning in their lives outside the classroom, where their interests ramp up into veritable obsessions. What are adolescents obsessed with? What might we see, if we become Jane Goodalls of early adolescence? First, teens are obsessed with gossip. The motivations of others — why did he do that? and what was he THINKING? — are hypothesized and talked to death. Second, that they’re pulled toward idealism. Many feel a dissatisfaction with the world as it is, and feel a romantic urge to make it a better place. They’re often lured into simplistic beliefs that promise to help them do that. Third, they love extremes: they want to find limits, and test them. Obviously, this can show up as risky behavior, but we can also see it in their love for the bizarre — note adolescents’ fascination in things like aliens, cryptids, and ghosts. (Egan loves pointing out that The Guinness Book of World Records is a perennial bestseller among kids at this age. How else would they find out who had the world’s longest fingernails?) Fourth, they gravitate toward heroes — people who push the edges of those limits. By celebrating heroes, they can vicariously share in their transcendence. Look for the posts hanging up in a teenager’s bedroom to guess what boundaries they feel most hemmed in by: athletes push against physical limits; a death metal guitarist might push against authority and conventional morality. An activist or entrepreneur might push against our dulled morality or our sense of what’s possible. Finally, we might spot teens taking up hobbies and making collections. Hobbies can be a way to identify yourself as part of a group against the rest of the world (“I’m the sort of person who goes bird-watching!”), and collections can be a way to climb the status ladder inside the community. Egan points out that a collection can also be a way to feel like you have control over what you’re discovering is a very big and complex world of detailed information (“I’ve spotted every one of the fifty most common birds of Texas — even the black-capped vireo!”) Egan’s insight is that these obsessions give teenagers a sense of meaning, and that we can use them as tools to make middle schools that overflow with meaning. From meaningless to meaning-soaked Again, Egan sketches out a new kind of curriculum subject-by-subject. Before, his trick was to ask where the subject first evolved out of; now, it’s to ask who first discovered or created the specific content we’re teaching. “All knowledge”, he writes, “is human knowledge. Everything we know is knowable through the lives of its inventors, discoverers, or users, and we can have access to that knowledge through the hopes, fears, or intentions that drove them”. Middle school math Who first discovered the concepts students learn in math? The answer, of course, is a wide diversity of curious men and women living across the world over the last few thousand years. Egan says: bring those people into how we teach math. If we used gossip and heroes to help students find it meaningful, what kind of math would result? When we teach the Pythagorean theorem, we should give a sense of who Pythagoras was — a cult-founder who worshiped numbers to find God, whose followers (according to a piece of ancient gossip) murdered one of their members who discovered irrational numbers! Q: Well, sure, that works for Pythagoras, but he’s a known nut job; surely most math doesn’t come from such interesting roots? When we teach the Cartesian coordinate system, students should meet Rene Descartes, the Calvinist French polymath who saw the possibility that math could decipher the world, if only we could unite algebra and geometry… and invented the xy-plane to do exactly that. When we teach scientific notation, we should call our students’ attention to the importance of the number zero, and tell them the story of the Pope who tried to introduce Arabic numerals to Christian Europe and may have been assassinated because of it. When we teach algebra, we should ask students why “algebra” is Arabic for “the fixing of bones”, and tell the story of what Muhammad ibn Musa al-Khwarizmi was up to. We could do this all day. Literally everything students learn in school was first invented or discovered by some interesting person who was struggling to accomplish something hard. To learn is to connect with those people, whether we know it or not. Egan says: help kids know it. Math has been dehumanized: re-humanize it. Q: So the math curriculum needs to become a history of math curriculum, and math teachers need to become history teachers? No, the content needn’t change. But with surprisingly little work, we can bring in the gossipy stories of heroes, and their obsessions can spread to students. Middle school science Who first discovered the things students learn about in science? If you’re thinking “scientists”, you’re only partially right. Most of the big-picture ideas that we now think of as “science” were discovered before the word “scientist” was invented, or the discipline was professionalized. Frequently, they were hatched by true amateurs, working in their free time, hungry to unlock the secrets of nature. We can use gossip and heroes to spread their obsessions to students just as we taught math, but Egan points out two twists. The first is that the content itself can take on heroic qualities: everything is impressive, when you look at it in a certain light. In an interview, Egan once said: “My book is an attempt to show that, indeed, everything in the world is wonderful, but that schools are designed almost to disguise this slightly shameful fact. We represent the world to children as mostly known and rather dull. The opposite is the case: we are surrounded by mystery, and what we know is fascinating”. What would even the most boring subjects look like, if we emphasized their heroic qualities? Well: What’s a tooth? Bone, wrapped in rock, surrounding tiny cells that your body feeds with blood. What’s a bar of chocolate? A crystal of jellyfish-shaped fat molecules stacked together; when you put it in your mouth you shake them apart into a writhing confusion. What’s the air around you? The bottom of a 10-mile-deep ocean; when you put your tongue over a soda straw and your Pepsi stops leaking out, it’s not because a “vacuum” is “sucking” it up, but because that ocean is squeezing it into your face. Again, we could do this all day! And in middle school science, we can. Everything in the world is wonderful; we can help students see this again and again. The second twist is that science is a subject rich in extremes. Here Egan introduces a concept that we’ll see crop up again: “15-minute segments”. To help us fit as much wonder as possible into a school day, he suggests we supplement the usual school subjects with a few quick lessons. To infuse science with extremes, he suggests we add on three: “human & natural records”, “extremes of animals & plants”, and “cosmology”. Middle school history Who first made the things students learn about in history? Why, the historical characters themselves! Since we’ve given kids a grounding in history in elementary school, now we can build on that, going through many of the same events as before, but in more depth, and more vividly. We’ll leverage the interest with other people’s inner lives to tell stories focusing on the perspectives of the people who made history — zooming in, when possible, on scandalous details. We’ll leverage the tool of idealism to choose historical characters who chafed against their surroundings, and understand what they were trying to accomplish. What was their vision of the world? What did they hope for, and what did they fear? Q: Isn’t the “great man” approach to history out of fashion? Egan’s approach doesn’t say that “great men” made history — it’s just leveraging gossip to help kids see history as something meaningful that can expand their own possibilities. “Early adolescence is commonly a time of intense and vivid emotional life, and also a time of deepest boredom and depression… [We] can give shape to the intermediate curriculum and offer the students a world that is rich, complex, varied, and as intense and vivid as their own emotional lives”. We also should add on another “15-minute segment” just to pump in as many biographies as possible, and from people who don’t always fit into the normal history curriculum. Call it “Brief Lives”, and throw in anyone who’s struggled to push some limit — Mary Wollstonecraft, Jesse Owen, Dietrich Bonhoeffer, one of the students’ great-aunts, whoever. As students get older, this can transition to “People and Their Ideas”. Here, we’d focus less on the details of the person’s life, and use it as a backdrop to showing how meaningful some of history’s most important ideas could be. Think Aristotle and syllogisms, Edward Said and orientalism, Confucius and propriety, Cornel West and race, Buddha on the four noble truths, Muhammad and the five pillars, Karl Marx and communism, Adam Smith and the invisible hand, Thomas Hobbes and the state of nature, John Locke and natural rights, Jeremy Bentham and utilitarianism, Thomas Aquinas on the sacraments, Martin Luther on faith, Voltaire on the freedom of speech… you get the idea. Q: Can you really get a profound understanding of utilitarianism in 15 minutes? Yes! The point of this segment isn’t to develop a systematic understanding of any one idea, it’s to introduce students to the exciting possibilities of human thought. (As a bonus, this might make them less likely to fall for the first ideology that they encounter later in life.) Diversity is important for this — as it is with culture. Throughout this, we should also be trying to expose students to as much cultural diversity as possible, because in high school, we’ll be trying to make sense of our society, and it’s impossible to do that unless we have something to compare it against. Middle school literature & language You might think that this subject would be easy — that middle school literature is already filled with “strong and clear narratives”, that it deals with “transcendent human qualities such as courage, love, and persistence”, that it focuses on “extremes of human experience”, that it examines “something strange and exotic”. You’d be right! Egan’s pretty happy with a bog-standard middle school literature curriculum, done well. In this part of the book, his spends most of his limited space suggesting three rather odd activities which could also be useful — especially for increasing students’ awareness of language, so they can use it better. The first is etymology — not, however, memorizing lists of roots, but in being told the entertaining backstories of specific words. Take the word “berserk”, for example — we now use it to mean something relatively mild (“if my mom catches me coming home late, she’ll go berserk”), but it comes from an old Norse word meaning “a raging warrior of superhuman strength”. And that’s because ber meant “bear” and serk meant “shirt”: soldiers of the bear cult would don the skin of a bear to, in their minds, transform into one — howling, foaming at the mouth, and gnawing the rims of their shields. (Most adults walk through life with little understanding that the words falling out of their mouths are entities, with their own back-stories. Communication is, at the very least, more interesting when we become aware of this.) The second is to add on another language to learn — not, this time, to become fluent in it, but just to become aware of how very different human languages can be. (For native English speakers, Sanskrit might work well, or Cantonese, or perhaps even ancient Egyptian. Again, the point isn’t for this language to be useful — it’s to explore diversity.) The final one is to study humor — not just jokes anymore, but comedy at its finest. Egan cites (at length!) Monty Python as a group of people who were particularly brilliant in their use of the English language. Examining their skits can lead us into not just an appreciation of semantics (the study of how meaning is made from smaller pieces, like etymology) but also pragmatics (the study of how meaning is made in social situations). Pretty heady stuff, for a conversation about a dead parrot. Part 4: A new kind of high school I’ll confess — I loved parts of high school… and among nerdy folks, I suspect I’m not alone. For some of us, this was a golden time. Even at my local public high school, I had access to academically thrilling classes — especially, in my last two years, advanced literature and history. I felt like I was finally understanding the ideas that mattered. In any case, Egan is quick to acknowledge that, at this level, the sort of education he advocates really is being practiced in some places. What he can add is an understanding of what makes it wonderful, how to make it even more wonderful, and how to make it wonderful for many, many more people. What’s the matter with high school? Far too often, even when high school classes are intellectual, they’re dry. For the majority of students, all this academic stuff is experienced as utterly lifeless, a mass of dead information to be squeezed inside one’s head for a test and then left to evaporate. Egan mocks the curriculum wars that seem to be a permanent feature of the teaching life; quoting the sociologist Pierre Bourdieu, he says “while the academic left and right bicker over whether the curriculum is too traditional or too radical, they fail to recognize that most students absorb so little of academic culture that the bickering is largely irrelevant”. Why so dry? Egan suggests three reasons to explain this. First, because high school academic classes are too often masses of small details with no sign of the big picture. Second, because they’re typically slavishly disciplinary, and aren’t able to address the questions that span the disciplines. Third, because they’re often designed to bring students through what everyone is sure of, and hide away any controversies. In all of these, Egan suggests that what’s called “academics” in high school is too often a dim imitation of what real academics are actually practicing. There’s a fourth reason, though, and it’s probably the biggest of all — by the time they get to high school, most students haven’t actually learned that much! An academic approach is designed to connect small details into the big picture; for people who arrive in high school (and college) classes without having already collected much in their heads, academics are going to taste dry. (An implication of this for anyone trying to improve schools is that we might not want to start with high schools. If your goal is to create a new kind of academic learning, first start at elementary school — or barring that, middle school.) What motivates mad scientists? When we wanted to re-conceive the elementary and middle school curriculums, we looked at what students were already good at — kids’ cognitive strengths and adolescents’ obsessions. For this level it might be easier to look — for reasons that will become clear when we finally unveil Egan’s crazy-sounding definition of education — at the sorts of things that bring intellectuals joy. Q: Which intellectuals? Take your pick. Galileo, Einstein, Smith, Marx, Goodall, Chomsky, Curie… all the people who took to the life of the mind like fish to water. But that’s a lot to hold in my mind at once, so I’m just going to think about Doc Brown from Back to the Future: He was high on intellectualism I’ve never been there, but the brochure looks nice Let’s call these people “mad scientists”. And let’s pretend we once again took up our job of being primatologists, and snooped on these folks “in the wild” (“in the lab”? this is beginning to get recursive…)… what would we find motivating them? Asking simple questions, for one. (What is space? What is society? What is a human? What is language?) Building general schemes (big theories) that hold lots of evidence together. Finding their place in the cosmos. And (perhaps above all) seeking certainty. Once again, Egan suggests we use these as tools to remake the curriculum. From dry to daring What could a high school curriculum look like, if it were rebuilt on these tools? Once again, Egan has a trick. This time, it’s to ask what fights have driven the development of each of these fields forward — and how we can help students enter them. First, a mini-segment! Intellectuals invented the academic disciplines to better pursue the life of the mind, but the disciplines can get in the way. Some of the most important intellectual discoveries that could help students are too big to fit into any of the disciplines. We need a place to introduce them plainly. Egan proposes another mini-segment — again, just 15 minutes a day, a few times a week — called “Metaknowledge”. Q: Isn’t that already in the International Baccalaureate program? Yes, he acknowledges that he’s borrowing from that! This segment would introduce ideas that would enrich student thinking across the disciplines: game theory, cognitive biases, systems thinking, Bayesian reasoning, epistemology, ethics, logic, cultural evolution, and so on. High school literature How can we help students enter the big fights of literature? Intellectuals of a literary bent — professors, critics, poets, novelists — delight in arguing over literature like rabbis arguing over the Talmud. Take, just for one example, the debates over Shakespeare’s character of Ophelia. Does she love Hamlet, or is she a victim of his emotional abuse? Is she truly insane, or is she acting? Is she passive, or is she pulling the strings? Oceans of ink have been spilled arguing over questions like these; our students can, perhaps, spill a few ounces more. The usefulness of arguing literature, for Egan, isn’t that it’s oh-so important for educated adults to know a lot about Ophelia. (This, again, was where the academicists went wrong — in thinking that being educated was about getting the best knowledge in your head.) Rather, arguing over literature is a training arena for the all-important intellectual move of this kind of understanding: building general schemes out of evidence, and struggling with anomalies. One person, for example, might hold that Ophelia is insane, and cite all sorts of obvious evidence — her father just was murdered by her lover, she rants nonsense while (bizarrely) handing out flowers to friends… But then he’s challenged when he reads a scholar pointing out that, to people in Elizabethan England, types of flowers have symbolic meanings. How does he deal with that? He could ignore it, claiming it an over-reading of Shakespeare. (Sometimes a flower is just a flower!) Or he could address it, complicating his own scheme. This intellectual work is best done with other people, who are incentivized to challenge your understanding of something, and go back and forth, building competing models and calling attention to anomalies. This process — the “dialectic” — pops up again and again in the academic disciplines. It’s the center of how understanding works, at this stage. And the nice thing about practicing it on literature is that, more so than in history or science, the evidence is shared knowledge — it’s right in front of everyone, written out. But there are other ways literature class can be helpful to the general life of the mind. Egan also suggests that we’ll want to specially include literature that helps students understand complex ideas. Camus, Orwell, Borges, Calvino might be particularly helpful here… and I imagine that genres like science fiction and magical realism might be particularly useful, too. (Note, though, that once again none of this requires a radical remaking of the curriculum, or of the canon of texts that we traditionally assign to high schoolers.) Q: Oh yes, the canon — what does Egan have to say about the canon wars? When he wrote Educated Mind in the nineties, the long-brewing canon war was approaching its inevitable apocalyptic climax. On one side of this Plain of Megiddo were the pro-canon traditionalists, arguing that we should keep assigning the texts that had been argued over for centuries. Facing them were the anti-canon reformers, arguing the standard texts over-represented the perspective of dead white men. Onto the middle of the plain rides Egan on a white horse, who bellows above the din: “I’VE GOT A BUSLOAD OF HIGH SCHOOLERS WHO WANTS TO JOIN IN, EVERYONE OKAY WITH THAT?” To do so, he says, we need to give students the arguments from both sides. So, for example, bell hooks, Edward Said, and China Achebe should be on the syllabus, as should Allan Bloom, Mortimer Adler, and Diane Ravitch. And of course they should actually read the texts cherished by both sides, too, so they can argue better. High school history How could entering the big fights help us reinvent high school history? First, we might look for dueling histories. It’s time for students to get into historiography and understand that history isn’t just what happened, it’s something we make. We might help kids read chapters from Howard Zinn’s socialist history of America alongside the corresponding chapters from Paul Johnson’s conservative history of America. How could big questions help? We want to help students see how various people have disagreed over some of the big questions of what human history is, at its most basic. We can have them compare Steven Pinker’s theory of civilization’s progress (Better Angels of our Nature) with Yuvah Noah Harari’s theory of civilization’s woes (Sapiens). We could have them compare so-and-so’s account of human history as an ever-expanding unlatching of energy sources with Robert Wright’s account of human history as unlatching more and more positive-sum games (Nonzero). What role could the lure of certainty play? To help them grow their skills at finding anomalies, we might help them work through pseudo-histories and conspiracy theories. Q: Conspiracy theories! Oh, come now, you’re playing with fire. Well, the world is on fire. Our students will spend the rest of their lives encountering terrible-but-beguiling arguments about how the world works; if we don’t prepare them for those, what have we been doing? So we should introduce arguments that the Moon landing was a hoax, that the Illuminati founded America, that aliens built the pyramids, and so on. At no point can we demean students for falling for any of these theories — the job of a teacher at this stage, Egan writes, is to support students in their reasoning even when their beliefs are offensive and stupid, gradually offering anomalies. There’s no way out of bad theories except through them. By the time students graduate, we want them to have wrestled with terrible ideas and — for a while — lost. They need to experience what it’s like to change their minds about something they felt strongly about. They need to viscerally realize, in Feynman’s famous phrase, “The first principle is that you must not fool yourself and you are the easiest person to fool.” High school natural science How could entering the big fights reinvent high school science? At present, so much of the high school science curriculum — especially “honors” classes — is oriented toward helping amass details. (The same is true of 100-level university classes, which famously “survey” the field to prepare for more advanced studies. I always thought this was stupid — of the huge lecture hall of students in my Geology 100 class, how many went on to take even a second course?) The meaty debates that propel science forward are held back. Egan complains: “The more general and speculative theories in any discipline are treated like an unconventional and disreputable relation who, even though the children find her exciting and entertaining, must be kept hidden from view, her very existence denied as long as possible”. This is a stupid approach — students with an adventurous bent are convinced that science isn’t for them. Egan proposes, simply, that we flip this, and organize high school science classes around the big debates. We shouldn’t be ashamed at how, well, adolescent this might look: “the dramatic, speculative, and contentious theories will be up-front in the early years of the [high school] curriculum”. What might those be? Egan doesn’t give a list, but we can spitball some: instead of explaining what “matter” is from the top down, a physics class could problematize “matter” by following the debates over the nature of dark matter and dark energy, and by becoming familiarized with the various interpretations of quantum mechanics
Inline links: In a biting essay, In my favorite of his books, https://substackcdn.com/image/fetch/$s_!ywm7!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Ff9c9b1ed-a260-4117-8679-0b5a32339748_1600x574.png, https://substackcdn.com/image/fetch/$s_!WPeH!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F62ea55f8-0458-484f-be45-7a011d050756_1600x625.png, https://substackcdn.com/image/fetch/$s_!FPXt!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fb017fc37-3151-4556-87f1-31a097cf7594_1600x574.png
Palestinian-American1 mentions across 1 issues

Palestinian-American is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between May 01, 2024 and May 01, 2024. The archive places it in contexts such as "Hanania himself is Palestinian-American". It most often appears alongside #MeToo, #StopAAPIHate, #StopAAPIHate.

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Palestinian-American
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Book Review: The Origins Of Woke
May 01, 2024 · Original source
Even though Arabs and Muslims are one of the most discriminated-against groups in the country, especially after 9-11, they didn’t have good lobbyists, so they got classified as white. According to Hanania, the government’s dividing line for white vs. PoC is at the Afghanistan-Pakistan border, and nobody knows what to do about eg Uzbeks. Hanania himself is Palestinian-American and seems salty about this.
Panax ginseng1 mentions across 1 issues

Panax ginseng is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between October 26, 2022 and October 26, 2022. The archive places it in contexts such as "everyone bought the fake Panax ginseng by clicking on the links". It most often appears alongside American ginseng, apple juice, Ashwagandha.

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Panax ginseng
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Highlights From The Comments On Supplement Labeling
October 26, 2022 · Original source
Labdoor is an affiliate marketing site masquerading as an independent testing site. They use flawed methodologies to give misleading data and profit off people clicking on their affiliate links to buy products. They had a completely FAKE Panax ginseng as their highest value rating product for OVER A YEAR after I showed them data proving it was fake. It was American ginseng cut with corn starch, and I provided them the data on it when they put up their ginseng ratings. It took them a whole year to even mention there was an issue, then they quietly just put a small note on the page saying the results were under investigation. They made affiliate commissions that whole time as everyone bought the fake Panax ginseng by clicking on the links on their rating page... It's not just like it was an innocent mistake. I called them out publicly over it, and we discussed it privately vi PM here on Reddit. They could have removed that product page when I alerted them, but it stayed up. Just insane to me.
pancreatic cancer1 mentions across 1 issues

pancreatic cancer is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between November 24, 2022 and November 24, 2022. The archive places it in contexts such as "Semaglutide has been accused of slightly increasing risk of pancreatic and thyroid cancers". It most often appears alongside ACE inhibitors, ACE inhibitors, Adderall.

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pancreatic cancer
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Semaglutidonomics
November 24, 2022 · Original source
“Mounjaro” sounds like the playful animal sidekick in a Disney movie. From a purely economic perspective, semaglutide costs the health system money (because it’s expensive) but also saves the health system money (because we don’t have to pay for obesity consequences like diabetes and heart attacks). Which effect wins out? According to the Institute for Clinical and Economic Review, benefits would outweigh costs if semaglutide cost less than about $8,000/year. Since it costs $15,000 year now, it’s not cost effective. But if Morgan Stanley’s model comes true and it costs $4,000/year in 2030, then it will be cost effective. So at some point, Medicare (and so insurance companies) may start covering it more out of self-interest. I can’t tell whether the model takes this into account or not. (there’s also a third-level effect where it costs the health system money again, because it prevents people from dying of obesity-related complications, and dead people stop needing expensive health care. I think health economists are supposed to ignore this level.) 11.3 million prescriptions at $4,000/year comes to $45 billion, but Morgan Stanley expects that not everyone will fill their prescriptions consistently or stay on the medication the same amount of time, leading to their $31 billion figure. Towards The Glorious Post-Obesity Transhuman Future The Morgan Stanley report shows that even the greediest pharma investors, openly plotting to medicalize obesity, can’t bring themselves to believe in more than 11 million US semaglutide patients by 2030. That’s less than 10% of the US obese population. Isn’t that kind of disappointing? We’ve got > 100 million people dealing with a condition that not only makes them unhealthy, but also causes them psychological distress, and makes lots of people low-grade disappointed in and repulsed by our society. And we’ve got an effective drug that treats the condition. And we’re going to use it on less than 10% of the people involved? In 2032, semaglutide goes off-patent. It will probably take a few years to sort out legal issues and ramp up generic production, but by the mid-2030s, its price will go way down. I don’t think there are technical barriers to getting it down as low as $10 - $100 per month. By then, maybe there will be even more exciting branded weight loss drugs for wealthy people to choose from. But at the very least, semaglutide itself should become much more widely available even to poor or uninsured patients. I’m not sure what will happen. Will there be an inflection point, where so many people use semaglutide that obesity becomes unusual again, and then the remaining obese people start using it just to fit in? Will obesity become an optional fashion statement, like shaving your head or getting a tattoo? Or will semaglutide end up disappointing us in some way, like so many promising drugs have before? I come at semaglutide from a transhumanist perspective. I want to hack genetics and biology until everyone is as tall as they want, as strong as they want, as smart as they want, and whatever gender they want. If you want wings, you should be able to have wings. And yes, part of this vision is everyone having the weight they want. I’m not sure this will happen, but for the first time I can see a clear path to how it might. Postscript 1: Should You Take Semaglutide? I can’t answer this, please ask your doctor. But I do want to add that there are potential side effects I haven’t mentioned in this post, including nausea, gastrointestinal problems, pancreatitis, and kidney problems. Semaglutide has been accused of slightly increasing risk of pancreatic and thyroid cancers. Studies have found trends in this direction, but these conditions are so rare that even over thousands of patients over many years, the increase hasn’t yet reached clear statistical significance. The current consensus position is that it may increase thyroid cancer by a tiny amount not relevant to most patients, and that it probably doesn’t increase pancreatic cancer. I think my father has looked over these data more and is less sure than other people about the lack of pancreatic cancer risk, but he can’t get the resources he needs to prove anything, and I can’t remember his exact argument. More broadly: like all medications, semaglutide has benefits and risks, and you shouldn’t blindly take it after reading one blog article. Postscript 2: Is There A Way To Cheat The System To Get Semaglutide For Lower Cost? Health care is much like airline tickets: everyone pays a different price for everything and there’s usually a secret way to get what you want for much less money. Is this true of semaglutide? Pharma company Novo Nordisk offers a Savings Card that they say brings the price down to as low as $25 per month. I’m a little suspicious of this - pharma company offers are rarely as good as they sound - but I don’t notice any obvious tricks in this one and it should probably be your first bet. This startup claims that they can get insured people semaglutide for a $25/month copay “after their deductible is met” by negotiating with the insurance company very effectively. I can’t imagine how that works or what they have to negotiate with, but they seem pretty convinced, so I would welcome more information. Otherwise, you don’t have many great options. Although there are two older forms of semaglutide not FDA-approved for weight loss - Ozempic and Rybelsus - these are both more expensive, milligram per milligram, than Wegovy itself. Canada is also of no help. The usual Canadian pharmacies don’t seem to carry Wegovy, and charge about the same amount for Ozempic as American pharmacies do. This article in Drug Discovery Trends says that compounding pharmacies have been selling semaglutide for $300/month, less than a quarter of the sticker price. This is a bit confusing: compounding pharmacies are small local operations permitted to dispense unusual medications by mixing existing ones together in nonstandard ways. They’re arguing that they can legally dispense the semaglutide because they’re mixing it with vitamins, which, fine, but how are they getting it in the first place? Everyone else seems as confused as I am: "Nobody knows how [compounding pharmacies are] getting it," said Karl Nadolsky, an endocrinologist at Spectrum Health. "Who's making it? [The pharma company that makes it] Novo [Nordisk]'s not giving it to them. They're the ones with the rights to the molecule, so how is anybody getting semaglutide?" Has nobody asked compounding pharmacists about this? Do they have a conspiracy of silence? Does the FDA sometimes send their goons in to extract the information, but the compounding pharmacists compound sleeping gas / smoke grenades and vanish into the night? Anyway, the usual authorities warn you not to take compounded semaglutide under any circumstances, but they’re the same people who tell you never to buy drugs from a Canadian pharmacy because they might be adulterated. You can decide how much you want to trust them. Postscript 3: What About Europe And The Rest Of The World? Countries that are not the US usually negotiate with pharmaceutical companies over price. Because of some combination of “negotiation works” and “they are free-riding off Americans’ hard work”, they usually get much lower prices. What does semaglutide cost elsewhere? This is hard to find out because government health agencies sometimes keep their prices secret, plus Wegovy mostly isn’t available in other countries yet. The only information I could find was from Britain, which is in the process of making Wegovy available to patients. It looks like NHS will “restrict the expensive drug’s availability to very obese people attending specialist weight-loss clinics”, but that it might be possible to get it from private clinics for £199/month = £2400/year. Wegovy has been approved in the EU but doesn’t seem to have made it there yet. I can’t find any information about any other country. Non-weight-loss-indicated versions of semaglutide are available in many countries, but I wouldn’t expect their health care systems to be flexible about redirecting it for weight. Canadian regulators have approved Wegovy, but it doesn’t seem to be available there yet. I haven’t seen any evidence that Ozempic costs less in Canada than it does in the US, and I’m not sure why. Maybe the pharma companies have figured out that anything that happens in Canada gets imported into the US, and they’re playing hardball this time. I don’t know whether Canadians will be able to get it for cheaper than Americans or not. Postscript 4: Predictions (all predictions are conditional on no singularity or global catastrophe) 10 million Americans on semaglutide (or yet-to-be-approved equally good or superior alternatives) by 2030: 75%
Inline links: Institute for Clinical and Economic Review, don’t think there are technical barriers, offers a Savings Card, This startup, about the same amount for Ozempic, This article in Drug Discovery Trends, Everyone else seems as confused as I am, NHS will, private clinics
pandemic prevention1 mentions across 1 issues

pandemic prevention is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between August 25, 2022 and August 25, 2022. The archive places it in contexts such as "And the same for pandemic prevention". It most often appears alongside AGI, AI-risk, Alexander Berger.

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pandemic prevention
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August 25, 2022
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August 25, 2022
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Highlights From The Comments On The Repugnant Conclusion And WWOTF
August 25, 2022 · Original source
Ditto seeing how little action climate change receives, for all the attention it gets. And the same for pandemic prevention. It's even worse for nuclear war prevention, or food supply security, which don't even get attention. And to be clear, all of these seem like they are obviously under-resourced with a discount rate of 2%, rather than MackAskill's suggested 0%. I'd argue this is true for the neglected issues even if we were discounting at 5%, where the 30-year future is only worth about a quarter as much as the present - though the case for economic reactions to climate change like imposing a tax of $500/ton CO2, which I think is probably justified using a more reasonable discount rate, is harmed.
Panel d1 mentions across 1 issues

Panel d is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between July 11, 2025 and July 11, 2025. The archive places it in contexts such as ""What the Heck is Going on in Panel d? Panel d is an immunoblot (Western blot)"". It most often appears alongside aducanumab, Alzheimer’s, Alzheimer’s Disease.

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Panel d
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1
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July 11, 2025
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July 11, 2025
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Your Review: Of Mice, Mechanisms, and Dementia
July 11, 2025 · Original source
Evidence that APP overexpression isn't driving toxicity, which can cause similar damage to the brain. This is very hard to control for, so the best course of action is to try to match human APP expression levels in your mouse model. Controls are an indispensable reality check for strong inference—the practice of designing experiments that not only test a hypothesis but aim to disprove it or eliminate alternatives. The concept was introduced in 1964 by the biophysicist John Platt, who observed that some scientific fields advance rapidly while others stagnate. The difference, he argued, wasn’t in the complexity of the problems or the brilliance of the researchers, but in the systematic use of what he called strong inference. Unlike the traditional scientific method, which often tests a single hypothesis against a null, strong inference begins with multiple competing explanations. It then designs experiments specifically intended to rule them out. Over time, this produces a branching tree of narrowing possibilities, steadily eliminating what doesn’t hold up. This approach also guides how we read. Asking what control would disprove the claim—or what alternative wasn’t tested—is the core of strong inference. Detective Work—Decoding the Paper With our backstory in hand and analytical toolkit in mind, let’s see if the PDAPP mouse delivers on the amyloid cascade hypothesis. It’s time to interrogate the key figures. In a paper like this, the figures are the empirical backbone of the argument. Of course, the authors have carefully chosen what to show and how to frame it. Our job is to assess whether the evidence supports their claims. Figure 1: Confirming the PDAPP Mouse Expresses Human APP Big picture message: The authors successfully engineered a mouse with a functioning human APP transgene. While Figure 1 has 5 parts, Panel d (below) is where we get the clearest confirmation that the human mutant APP transgene integrated itself into the mouse genome and produced Aβ in the expected location in the mouse brain. Stare at Panel d for a few seconds and then we’ll talk about it. What the Heck is Going on in Panel d? Panel d is an immunoblot (Western blot), a technique that tells us whether a specific protein is being produced in a sample. The figure compares human amyloid precursor protein expression in samples from three brains, corresponding to the three “lanes” shown along the top: a normal mouse (Lane 1), a mouse with the human APP transgene (Lane 2), and a human who had Alzheimer’s disease (Lane 3). The blots (the bands and blobs) are the data. For purposes of this figure, proteins can differ in two important ways: They can differ in molecular weight (size), scored on the scale along the vertical axis on the left.
Inline links: 1964 by the biophysicist John Platt, https://substackcdn.com/image/fetch/$s_!f1eu!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F70732126-ef32-4d46-a74a-490385359928_414x660.jpeg
What the Heck is Going on in Panel d? Panel d is an immunoblot (Western blot), a technique that tells us whether a specific protein is being produced in a sample. The figure compares human amyloid precursor protein expression in samples from three brains, corresponding to the three “lanes” shown along the top: a normal mouse (Lane 1), a mouse with the human APP transgene (Lane 2), and a human who had Alzheimer’s disease (Lane 3). The blots (the bands and blobs) are the data. For purposes of this figure, proteins can differ in two important ways: They can differ in molecular weight (size), scored on the scale along the vertical axis on the left.
The PDAPP mouse sample in lane 2 will have the same molecular weight (height on vertical axis) and expression level (intensity and spread) as the human sample in lane 3. Why do we want to see these results? It matters because our ultimate goal is to develop treatments that work in people, not just in mice. To make that leap from a mouse model, the PDAPP mouse needs to replicate the key features of Alzheimer’s disease in humans—not just produce APP but drive similar amyloid-induced disease processes in the brain. Ok, so on point one, ✔ — nothing in lane 1. Point two? ❌ While the human sample has distinct bands in lane 3, the PDAPP mouse in lane 2 appears as a giant, smeared blob. Are these the same protein size? Impossible to tell! This happens because, relative to the human sample, the PDAPP mouse is drowning in APP—at least 10 times more, according to the paper’s text, and possibly much more by eye. When you do a Western blot, you set an exposure time for your image, just like with a manual camera: too short an exposure, and faint bands won’t appear; too long, and strong signals become an oversaturated mess. Here, no single exposure could produce similar-looking PDAPP and human samples. It’s like trying to take a photo of a candle next to the sun—you can’t adjust for both at once. A proper Western blot should show clean bands to confirm protein size and check for unexpected degradation products, but this overloaded mess makes it impossible to tell whether APP is being processed normally. A Western blot like the one shown in Panel d usually indicates either sloppy technique (overloading the gel, overexposing) or a fundamental issue with the model itself (massive expression differences between samples). The fine print explains why: the PDAPP mouse carries 40 copies of the APP transgene, all inserted at a single site in the genome. For context: ✔ At most, humans have 2 copies of APP (one from each parent). ✔ PDAPP mice have 40 human copies—plus their 2 normal mouse copies. I’m sure this blot led to high-fives in the lab—earlier models struggled to express APP at all, so getting massive overexpression must have felt like a breakthrough. But now I’m worried. If we’re trying to create a human-comparable Alzheimer’s model, this much APP might be way too much. Why might this be a problem? APP expression at this level doesn’t mirror expression levels in human Alzheimer’s. Alzheimer’s patients don’t have 40 copies of APP. If it takes this much overexpression (and a mutant form at that!) to drive pathology in mice, are these mice even an appropriate animal model for Alzheimer’s?
pangolins1 mentions across 1 issues

pangolins is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between March 28, 2024 and March 28, 2024. The archive places it in contexts such as "intermediate hosts (pangolins, raccoon-dogs, etc)"; "usual coronavirus intermediate hosts (pangolins, raccoon-dogs, etc)". It most often appears alongside ACX comment thread, ACX subreddit, Asia.

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pangolins
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March 28, 2024
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March 28, 2024
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Practically-A-Book Review: Rootclaim $100,000 Lab Leak Debate
March 28, 2024 · Original source
Lineage A (left) was used by the Minoan Cretans, but has never been deciphered. Lineage B (right) was used by the Mycaeneans for lists of palace goods. This matches Saar’s story above. The lab leaked to somewhere else in Wuhan, not the wet market. The virus spread undetected in the population for a while. During this time, it mutated to Lineage B. Then one of the people with Lineage B went to the wet market and started a superspreader event. The authorities sampled the patients, found Lineage B, then started looking elsewhere. Later they detected some of the earlier Lineage A cases. The market is unlikely to be the origin of the pandemic, because the original Lineage A strain wasn’t found there. Peter: Although Lineage A is evolutionarily older, Lineage B started spreading in humans first. We know this because Lineage B is more common. Throughout the early pandemic, until the D614G variant drove all other strains extinct, a consistent 2/3 of the cases were B, compared to 1/3 A. Both strains spread at the same rate, so the best explanation is that B started earlier than A. Since COVID doubles every 3-4 days, probably Lineage B started 3-4 days earlier than Lineage A, which explains why it’s always been twice as many cases. But also, Lineage B also has more internal genetic diversity than Lineage A. In general, older viruses have more genetic diversity (the “molecular clock”). This is further evidence that B started spreading first. Pekar 2022 and Pipes 2021 do analyses with known parameters for spread rate and diversity, and find 90%+ odds that Lineage B was the first one in humans. Why did the older strain start spreading later? Probably the virus crossed from bats into raccoon-dogs on some raccoon-dog farm out in the country. It spread in the raccoon-dogs for a while, racking up mutations, including the (less mutated) Lineage A strain and the (slightly more mutated) Lineage B strain. Then several raccoon-dogs were taken to Wuhan for sale, including one with Lineage A and another with Lineage B. The one with Lineage B passed its virus to humans earlier. Then 3-4 days later, the Lineage A one passed its virus to humans. Lineage A was first found in a Wuhan neighborhood right next to the wet market (closer to the wet market than 97% of Wuhan’s population). Again, it would be a bizarre coincidence if a lab leak pandemic was first detected at a wet market. But it would be an even more bizarre coincidence if a lab leak pandemic separated into two strains, and both were first detected at a wet market! Although no known wet market cases were Lineage A, a positive Lineage A environmental sample was found at the wet market, and everyone agrees most cases went undetected. So maybe the Lineage B raccoon-dog spread its virus to a vendor, and that sub-strain mostly stayed in the market. But the Lineage A raccoon-dog spread its virus to a customer, who went back to his house nearby, and that strain spread in the neighborhoods next to the market. This is the only story that explains the evolutionary precedence of A, the greater spread and older molecular clock of B, and the fact that both strains were first found very close to the wet market. Yuri/Saar: Lineage B could be more common and diverse because it got the advantage of a super-spreader event in the wet market. There are a few scattered cases of intermediates between A and B, and a few other scattered cases of lineages that seem even more ancestral (ie closer to the bat virus) than either. This doesn’t make sense in a double spillover hypothesis. But it does make sense if the lineages separated in human transmission somewhere between the lab and the first super-spreader event at the wet market. Peter: Again, the wet market wasn’t a super-spreader event. COVID spread in the wet market at exactly its normal spread rate, doubling about once every 3.5 days. Stop calling the wet market a super-spreader event. The scattered cases of “intermediates” are sequencing errors. They were all found by the same computer software, which “autofills” unsequenced bases in a genome to the most plausible guess. Because Lineage B was already in the software, depending on which part of a Lineage A virus you sequenced, you might get one half or the other autofilled as Lineage B, which looked like an “intermediate”. We know this because all the supposed “intermediates” were partial cases sequenced by this particular software. We can confirm this by noting that there are too many intermediates! That is, where Lineage A is (T/C) and Lineage B is (C/T), the software found both (T/T) “intermediates” and (C/C) “intermediates”. But obviously there can only be one real intermediate form, and we have to dismiss one or the other. But in fact we can dismiss both, because they were both caused by the same software bug. The scattered “progenitor” cases - those closer to the ancestral bat virus than either A or B - are reversions, ie cases where a new mutation in the virus happened to hit an already-mutated base and shift it back towards the ancestral virus. We know this because all of these “progenitors” were scattered cases found months after the pandemic started, often in entirely different countries from Wuhan. If these were real progenitor viruses, they would have either fizzled out or exploded into a substantial portion of all cases, not be found one time in one guy in Malaysia. Given the number of mutations the virus developed over the course of the pandemic, it’s inevitable that some of them would be mutations that bring it closer to the original bat virus, and in fact we find the number of “progenitors” found very nicely matches the number of progenitor-appearing viruses we would expect by chance. And in many cases, we know the “progenitors” are newer than the original lineages, because they also have some of the later mutations that Lineage A or B picked up along the way, alongside their apparent ancestral-bat-virus-like mutations. Session 2: Viral Genetics Yuri: Two years before COVID, scientists at the Wuhan Institute of Virology, together with colleagues at the University of North Carolina, sent in a grant proposal for the DEFUSE program. This program, intended to locate and better understand potential future pandemic viruses, involved going into bat caves and collecting new coronaviruses. Once they had them, they would do gain-of-function: specifically, they would add a furin cleavage site to make them more infectious and see what happened. (quick interlude: COVID’s spike protein has two sections: one binds to human cells through the ACE2 receptor, the other helps fuse with the cell after binding. In order to avoid the immune system, it hides both of these into one spike. But when it reaches a cell, it needs to separate them again. It takes advantage of a human respiratory enzyme, furin, to do the separation - this also ensures that it only infects its primary target, human respiratory cells. The part of COVID that lets it get separated by furin is called the “furin cleavage site”. COVID’s bat-virus ancestors were gastrointestinal viruses; the addition of a furin cleavage site was what made them respiratory viruses.) We’ve found two close relatives of COVID: bat viruses called RATG-13 and BANAL-52. In particular, COVID looks more or less like BANAL-52 plus a furin cleavage site. There are 1500 sarbecoviruses, members of the family of viruses that includes SARS and SARS2/COVID. None of them except COVID have furin cleavage sites. BANAL-52, COVID’s closest ancestor, doesn’t even have anything resembling one that could mutate into a functional furin cleavage site like COVID’s. Instead, COVID - which mostly just resembles BANAL-52 with a few scattered single-point mutations - has twelve completely new nucleotides in a row - a fully formed furin cleavage site that came out of nowhere. There is nowhere else in the genome that COVID differs from BANAL-52 in such a profound way. It’s just BANAL-52 plus a little bit of random mutation plus a fully-formed furin cleavage site that came out of nowhere. Further, the furin cleavage site is weird. It uses the protein arginine twice. But instead of the nucleotides coding for arginine in the usual viral way, both times it uses the codons CGG - the way that higher animals code for arginine. This works fine - it’s just not how viruses do it. So the obvious conclusion is that WIV, which said in 2018 that it was going to find viruses and add furin cleavage sites to them, found a close relative of BANAL-52 and added a furin cleavage site. Since they were humans, and most familiar with the human way of encoding arginine, they added it as CGG both times. COVID seemed surprisingly optimized for infecting humans. Of fifty animals it was tested in, including the usual coronavirus intermediate hosts (pangolins, raccoon-dogs, etc), it was best at infecting human cells. Further, a virus that enters a new species will usually show a burst of mutations as it “figures out” the best way to adapt to that species’ unique biology. But COVID has had a pretty constant mutation rate in humans, from the beginning of the pandemic to the end. That suggests it was already adapted to humans. This could be because the lab screened for viruses with existing adaptations, because they passed it through humanized mice in the lab, or because it adapted in the hundreds of undetected cases that happened between the lab and detection in the wet market. Usually, research with potentially dangerous coronaviruses is done in BSL-3 or 4, ie high to very-high security. But WIV was irresponsibly doing it in BSL-2, ie medium security. The researchers weren’t even required to wear masks. In general, about 1/500 labs will leak any given pathogen they’re working on (?!). But because WIV was researching such an infectious virus in such an irresponsible way, the odds of a leak were much higher. The most likely explanation for all these facts is that WIV went ahead and did the gain-of-function research they said they were going to do (the particular DEFUSE grant proposal we know about got rejected, but it proves that Wuhan wanted to do this, and they could easily have gotten funding somewhere else, or done it out of their regular budget). They found a close relative of BANAL-52 and added a furin cleavage site as a simple twelve-nucleotide insertion, using the human method of encoding arginine that their genetic engineers were familiar with. Then it leaked, spread for a while in the general Wuhan population, and eventually made it to the wet market where it got detected. Peter: As mentioned earlier, the DEFUSE grant was rejected. Further, the grant said that the Wuhan Institute of Virology was responsible for finding the viruses, and the University of North Carolina would do all the gain-of-function research. This was a reasonable division of labor, since UNC was actually good at gain-of-function research, and WIV mostly wasn’t. They had done a few very simple gain-of-function projects before, but weren’t really set up for this particular proposal and were happy to leave it for their American colleagues. Even if WIV did try to create COVID, they couldn’t have. As Yuri said, COVID looks like BANAL-52 plus a furin cleavage site. But WIV didn’t have BANAL-52. It wasn’t discovered until after the COVID pandemic started, when scientists scoured the area for potential COVID relatives. WIV had a more distant COVID relative, RATG-13. But you can’t create COVID from RATG-13; they’re too different. You would need BANAL-52, or some as-yet-undiscovered extremely close relative. WIV had neither. Are we sure they had neither? Yes. Remember, WIV’s whole job was looking for new coronaviruses. They published lists of which ones they had found pretty regularly. They published their last list in mid-2019, just a few months before the pandemic. Although lab leak proponents claimed these lists showed weird discrepancies, this was just their inability to keep names consistent, and all the lists showed basically the same viruses (plus a few extra on the later ones, as they kept discovering more). The lists didn’t include BANAL-52 or any other suitable COVID relatives - only RATG-13, which isn’t close enough to work. Could they have been keeping their discovery of BANAL-52 secret? No. Pre-pandemic, there was nothing interesting about it; our understanding of virology wasn’t good enough to point this out as a potential pandemic candidate. WIV did its gain-of-function research openly and proudly (before the pandemic, gain-of-function wasn’t as unpopular as it is now) so it’s not like they wanted to keep it secret because they might gain-of-function it later. Their lists very clearly showed they had no virus they could create COVID from, and they had no reason to hide it if they did. COVID’s furin cleavage site is admittedly unusual. But it’s unusual in a way that looks natural rather than man-made. Labs don’t usually add furin cleavage sites through nucleotide insertions (they usually mutate what’s already there). On the other hand, viruses get weird insertions of 12+ nucleotides in nature. For example, HKU1 is another emergent Chinese coronavirus that caused a small outbreak of pneumonia in 2004. It had a 15 nucleotide insertion right next to its furin cleavage site. Later strains of COVID got further 12 - 15 nucleotide insertions. Plenty of flus have 12 to 15 nucleotide insertions compared to other earlier flu strains. Sometimes insertions happen because of a mistake in viral replication. Other times the virus gets confused between its own RNA and its host’s, and splices a bit of the host RNA into the virus. This would neatly explain why the insertion used the unusual coding CGG for arginine, which is common in animals but rare in viruses. On the other hand, it’s not that rare in viruses - COVID uses CGG for arginine about 3% of the time. And human engineers don’t necessarily use it any more than that - Peter was able to find one example of humans adding arginine to a virus, and 0 out of the 5 arginines added were CGG. COVID’s furin cleavage site is a mess. When humans are inserting furin cleavage sites into viruses for gain-of-function, the standard practice is RRKR, a very nice and simple furin cleavage site which works well. COVID uses PRRAR, a bizarre furin cleavage site which no human has ever used before, and which virologists expected to work poorly. They later found that an adjacent part of COVID’s genome twisted the protein in an unusual way that allowed PRRAR to be a viable furin cleavage site, but this discovery took a lot of computer power, and was only made after COVID became important. The Wuhan virologists supposedly doing gain-of-function research on COVID shouldn’t have known this would work. Why didn’t they just use the standard RRKR site, which would have worked better? Everyone thinks it works better! Even the virus eventually decided it worked better - sometime during the course of the pandemic, it mutated away from its weird PRRAR furin cleavage site towards a more normal form. Further, COVID’s furin cleavage site was inserted via what seems to be a frameshift mutation - it wasn’t a clean insertion of the amino acids that formed the site, it was an insertion of a sequence which changed the context of the surrounding nucleotides into the amino acids that formed the site. This is a pointless too-clever-by-half “flourish” that there would be no reason for a human engineer to do. But it’s exactly the kind of weird thing that happens in the random chance of evolution. COVID is hard to culture. If you culture it in most standard media or animals, it will quickly develop characteristic mutations. But the original Wuhan strains didn’t have these mutations. The only ways to culture it without mutations are in human airway cells, or (apparently) in live raccoon-dogs. Getting human airway cells requires a donor (ie someone who donates their body to science), and Wuhan had never done this before (it was one of the technologies only used at the superior North Carolina site). As for raccoon-dogs, it sure does seems suspicious that the virus is already suited to them. The claim that COVID is uniquely adapted to humans is false. The paper that claimed that defined how well COVID was adapted to different animals by those animals’ difference (on the relevant cell receptors) from humans. So in its methodology, humans came out #1 by default. If you don’t do that, COVID is better-adapted to many other animals. It’s not necessarily true that viruses see a burst of mutations when they enter a new host. COVID spread to deer and mink, and in neither case was there a burst of mutations. COVID has a pretty simple job of infecting respiratory cells and is already very good at it, regardless of species. In Yuri’s model, Wuhan Institute of Virology picked up a discarded grant and decided to do the gain-of-function half allotted to a different university, despite their relative inexperience. They skipped over all the SARS-like viruses they were supposed to work on, and all the standard gain-of-function model backbones, in favor of BANAL-52, a virus which would not be discovered for another two years, but which they somehow had samples of, which they had for some reason decided to keep secret despite its total lack of interestingness. Then they would have had to eschew all usual gain-of-function practices in favor of inserting a weird furin cleavage site that shouldn’t have worked according to the theory they had at the time, via a frameshift mutation. Then they would have had to culture it, a technique beyond their limited capabilities. Then it would have had to leak, and magically show up again in front of the raccoon-dog stall at a wet market. Yuri: WIV wouldn’t have needed to keep BANAL-52 “secret” in some kind of sinister way. Plenty of researchers have backlogs of work they haven’t published yet. Probably they a found BANAL relative in one of their normal sampling trips, did some preliminary studies on it, and planned to publish it later once they cleaned up their data. Everyone works like this. The part of DEFUSE saying that they would only work on viruses that were 95% similar to SARS is unclear and might mean something else. It looks more like they say they’ll start with those viruses, but also do some work on novel viruses. BANAL-52 could have been one of the novel viruses. The furin cleavage site is weird, but the researchers might have done that on purpose, to make the virus easier to keep track of, or to test different furin cleavage sites. Depending on the exact BANAL-52 relative they used, it might not even be a frameshift; there’s a particular way to spell serine that would make the insertion more natural. The claims that COVID can’t be cultured in normal media are based on speculative original research by Peter and might not hold up. Peter: WIV did most of its virus-gathering in a trip to a Yunnan cave between 2010 and 2015. All those viruses have long since been processed and added to the database. There’s no sign that they made more trips to Yunnan caves, and no reason for them to keep that secret. So the idea that they might just have some new viruses they didn’t publish doesn’t hold up. But suppose they did make more trips. Given the amount of time between the DEFUSE proposal and COVID, if they kept to their normal virus-collection rate, they would have gotten about thirty new viruses. What’s the chance that one of those was BANAL-52? There are thousands of bat viruses, and BANAL-52 is so rare that it wasn’t found until well after the pandemic started and people were looking for it very hard. So the chance that one of their 30 would be BANAL-52 is low. Also, they said in DEFUSE that they planned to go back to the same Yunnan cave. But BANAL-52 was found far away from that cave, so unless it ranged over a wide area, they probably couldn’t have found it even if they got very lucky. Session 3: Closing Arguments This third debate was supposed to be about “inference”, ie how much Bayesian evidence was provided by each of the facts given so far, and how to fit them into the Rootclaim probabilistic model. I’m going to relegate my summary of the more probabilistic half to the next section of this post, and just include the closing arguments here. Saar: Peter’s case hinges on the idea that it’s very improbable that a lab leak pandemic would first show up at a wet market. But this isn’t necessarily improbable. The Huanan Seafood Market had several factors that made it a likely location for a superspreader event. It was busy, with over 10,000 visitors a day. Many of the people there (eg the 1,000 vendors) came back daily, letting them reinfect each other. It had poor ventilation, especially in the high-positivity area near the raccoon-dog stall. It had cold wet surfaces on which the virus could survive for long periods. It was indoors, which prevented UV light from killing the virus. Given a small amount of sporadic COVID going around Wuhan, it’s not surprising for the first place it started spreading en masse to be a wet market. In fact, we have several examples of this. When China was COVID Zero, there would occasionally be small outbreaks that the authorities would have to contain. Most of these were at wet markets. For example, the big COVID outbreak in Beijing started at Xinfadi Market, their local seafood market. This couldn’t be an animal spillover, because there were no raccoon-dogs or other weird wildlife there. So it must be that wet markets are natural places for superspreader events. There are several other examples, which make up about half of the total outbreaks in Zero COVID era China, plus others in Singapore and Thailand. Since COVID clusters concentrate in wet markets even when there is no animal spillover, we should accept this as a property of the virus, and not attribute any significance to the fact that this happened in Wuhan too. Peter: About 1/10,000 citizens of Wuhan was a wet market vendor. So there’s a 1/10,000 chance that the first known COVID case should be a wet market vendor by chance alone. Weibo lists the most popular places for people to check in to their network on their phones, and the wet market was the 1600th most popular place in Wuhan, meaning that if you weight locations by busy-ness, there’s a less than 1/1600 chance that the first cases would be in the wet market. Yes, the wet market is indoors, has mediocre ventilation, has repeat visitors, etc. So do thousands of other places in Wuhan, like schools, hospitals, workplaces, places of worship. The wet market isn’t special in any way. And again, it wasn’t a superspreader event! COVID spread at the same rate in the wet market as it does everywhere else: doubling once per 3.5 days. It doesn’t matter what kinds of arguments you can come up with for why the wet market should have been the perfect superspreader event location, we can look at it and see that it wasn’t. It’s an environment that spreads COVID at exactly the normal rate. Zero COVID era Chinese outbreaks were concentrated in wet markets because they received infected animal products. We know why there was an outbreak in the Xinfadi Market in Beijing: it was because the seafood stall got frozen fish from some non-Zero-COVID country, the fish had COVID particles on it, and the vendor got infected and spread it to everyone else. Something like this is true for the other Chinese wet market based outbreaks we know about it. So this makes the opposite point you think it does: wet markets start outbreaks because there are infected goods being sold there. Then the virus spreads through the wet market at a completely normal rate. Saar: The Weibo list of 1600 places bigger than the wet market is likely inaccurate, because it's based on check-in data and people don't check in to seafood markets. Most of those 1600 places aren't amenable to superspread. The 70 markets supposedly bigger than Huanan are irrelevant, because they're supermarkets, open air markets, etc. Huanan is the largest seafood market in central China, and a more likely place for the first cluster of cases to be noticed. Markets weren't a common spillover location in SARS1, so the zoonosis hypothesis hasn't "called" this event in a way that should give them a high Bayes factor. And there’s still plenty of evidence for isolated (though not super-spreading) pre-market cases. A British expatriate in Wuhan, Connor Reed, says he got sick in November, three weeks before the first wet market case. Later the hospital tested his samples and said it was COVID. Another paper reports 90 cases before the first wet market one. Peter: Connor Reed was lying. The case wasn’t reported in any peer-reviewed paper. It was reported in the tabloid The Daily Mail, months after it supposedly happened. He also told the Mail that his cat died of coronavirus too, which is rare-to-impossible. Also, to get a positive hospital test, he would have had to go to the hospital, but he was 25 years old and almost no 25-year-olds go to the hospital for coronavirus. His only evidence that it was COVID was that two months later, the hospital supposedly “notified” him that it was. The hospital never informed anyone else of this extremely surprising fact which would be the biggest scientific story of the year if true. So probably he was lying. Incidentally, he died of a drug overdose shortly after giving the Mail that story; while not all drug addicts are liars, given all the other implausibilities in his story, this certainly doesn’t make him seem more credible. And in any case, he claimed he got his case at a market “like in the media” The other 90 cases are also fake. A lab leak guy found a paper that mentioned 90 more cases than other papers, and made up a conspiracy theory where the author was trying to secretly communicate that there had been 90 secret cases before any of the confirmed cases, even though there was nothing about this in the text of the paper. But actually that paper just counted cases differently than other papers, and they were referring to normal cases after the pandemic officially started. Again, I’ll come back to the discussion about inference later, but for now, here’s a table of both sides’ reasoning. This exact presentation comparing both analyses is mine3, but you can see Saar’s version here, and Peter’s starting at 45:33 of this video. Slightly made up; the two sides didn’t express their probabilities in the same way and I had to make editorial decisions to match them. Note that these aren't entirely comparable because Peter is being laxer about out-of-model probability than Saar. Although Saar's final odds here are 533-to-1, this just the central estimate. Rootclaim’s real final probability is 94% lab leak. You can see their analysis here. And The Winner Is . . . … … … … … Peter and the zoonosis hypothesis. This was a decisive victory. There were two judges, who each gave separate verdicts (or were allowed to declare a draw). Both judges decided in favor of Peter. You can see the judges’ own summary of their reasoning here (Will, Eric) Manifold agreed with the judges. There was a prediction market on who would win. It started out 70-30 in favor of lab leak. As the videos came out, zoonosis started doing better and better. I don’t want to take the exact final numbers too seriously, since I think some of the later price increases involved hints from the participants’ behavior. But it’s clear which way viewers thought the wind was blowing4. Around the same time, the Good Judgment Project - Philip Tetlock’s group studying superforecasters - put out a report on the lab leak hypothesis. After studying it in depth, his forecasters ended up 75-25 in favor of zoonosis. The Rootclaim debate was one of ten sources they said they found especially interesting. And also around the same time, and unrelated to any of this, the Global Catastrophic Risks Institute surveyed experts (“168 virologists, infectious disease epidemiologists, and other scientists from 47 countries”) and found the same thing (though see here for some potential problems with the survey): For what it’s worth, I was close to 50-50 before the debate, and now I’m 90-10 in favor of zoonosis. III. The Math And The Aftermath The third debate session was about “inference”, how to put evidence together. I put this part off until after disclosing the winner, because I wanted to talk about some of these issues at more length. The Math: Judges Both judges included a probabilistic analysis in their written decision. Here’s the same table as above, expanded to add the judges: I shoehorned the judges’ factors into the categories I already had; some of them were actually subtly different from Peter’s, Saar’s, and each other’s. The “priors” category is especially a mess here. We’ll go over these later, but I get the impression that they both thought of probabilistic analyses as an afterthought. For example, Judge Eric wrote 30,000 words about which considerations moved him, and only then includes the analysis, saying: I am not convinced that this Bayesian calculation is even an appropriate way to estimate the relative posterior probability of Z and LL; it just seemed fair that after criticizing Rootclaim’s calculations at length I should make an attempt at it myself. Judge Will’s decision ran to 10,000 words. He said he independently tried both reasoning it out intuitively, and running the Bayesian analysis, and was relieved when these two methods returned the same result. He said: I am skeptical that the Bayesian decision making/evaluation methods are any more "objective" than [intuitive reasoning]. I think they maximize legibility, not objectivity, and tend to hide the intuitive/heuristic portion in the data inclusion step and values, where it’s harder to see . . . I am not skilled in the Bayesian method, and I am sure I made significant mistakes. More time and practice would improve and refine my estimates. At the fundamental rules of the universe level, Bayesian analysis must be the best way to evaluate evidence. However, I am unsure that it’s a good strategy for a human given our cognitive limitations, and doubly unsure it’s truly being used (in the dispassionate sense) where the outcome is social desirability/fame/Twitter likes. I’m focusing on this because Saar’s opinion is that the debate went wrong (for his side) because he didn’t realize the judges were going to use Bayesian math, they did the math wrong (because Saar hadn’t done enough work explaining how to do it right), and so they got the wrong answer. I want to discuss the math errors he thinks the judges made, but this discussion would be incomplete without mentioning that the judges themselves say the numbers were only a supplement for their intuitive reasoning. That having been said, let’s look deeper into some of Saar’s concerns. The Math: Extreme Odds Saar complained that Peter’s odds were too extreme. For example, Peter said there was only a 1/10,000 chance that a lab leak pandemic would first show up at a wet market. Peter’s argument went something like: obviously a zoonotic pandemic would start at a site selling weird animals. But a lab leak pandemic - if it didn’t start at the lab - could show up anywhere. 1/10,000 Wuhan citizens work at the wet market. So if a lab leak was going to show up somewhere random, the wet market was a 1/10,000 chance. Saar had specific arguments against this, but he also had a more general argument: you should rarely see odds like 1/10,000 outside of well-understood domains. In his blog post, he gave this example: A prosecutor shows the court a statistical analysis of which DNA markers matched the defendant and their prevalence, arriving at a 1E-9 probability they would all match a random person, implying a Bayes factor near 1E9 for guilty. But if we try to estimate p(DNA|~guilty) by truly assuming innocence, it is immediately evident how ridiculous it is to claim only 1 out of a billion innocent suspects will have a DNA match to the crime scene. There are obviously far better explanations like a lab mistake, framing, an object of the suspect being brought by someone to the scene, etc. So the real p(wet market|lab leak) isn’t the 1/10,000 chance a pandemic arising in a random place hits the wet market, but the (higher?) probability that there’s something wrong with Peter’s argument. Then Saar tried to show specific things that might be wrong with Peter’s argument. I didn’t find his specific examples convincing. But maybe the question shouldn’t be whether I agreed with him. It should be whether I’m so confident he’s wrong that I would give it 10,000-to-1 odds. This makes total sense, it’s absolutely true, and I want to be really, really careful with it. If you take this kind of reasoning too far, you can convince yourself that the sun won’t rise tomorrow morning. All you have to do is propose 100 different reasons the sunrise might not happen. For example: The sun might go nova.
Inline links: Pekar 2022, Pipes 2021, says, 3, here, this video, https://substackcdn.com/image/fetch/$s_!8aU2!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F815fe32d-d7ea-401b-b3a2-d8cd25b52ee8_490x780.png, https://substackcdn.com/image/fetch/$s_!0Tm_!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fd0492f69-7b7e-4611-9d76-64ef8d7f59d5_511x511.png, Will, Eric, agreed, 4, put out a report on the lab leak hypothesis, https://substackcdn.com/image/fetch/$s_!g7k2!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F37f1b493-b556-41ec-925e-03f9d8bc26cb_1456x849.webp, surveyed experts, see here, https://substackcdn.com/image/fetch/$s_!Zejl!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fe9c88e87-b6ca-4c6d-840e-24da726f50b7_975x365.png, https://substackcdn.com/image/fetch/$s_!T5rV!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F4983e2cd-4151-42de-9685-08037ef7a8e8_635x788.png
Panic Attacks1 mentions across 1 issues

Panic Attacks is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between September 07, 2023 and September 07, 2023. The archive places it in contexts such as "5: Chronic Pain, Panic Attacks, Or, If You Insist, Nightmares ... Same with panic attacks, anxiety, etc". It most often appears alongside ADHD, African savanna, asexuality.

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Panic Attacks
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Contra Kirkegaard On Evolutionary Definitions Of Mental Illness
September 07, 2023 · Original source
A 65 year old man who’s only attracted to adult women 40+. Most people in our society would classify 1 (an ephebophile) and 2 (a non-obligate pedophile) as mentally ill or at least worrying edge cases. But I think Emil’s theory rules that only Person 3 (the man attracted to people close to his own age) is mentally ill, since he’s ruled out mating with the vast majority of fertile women. 4: Plato …never had children. “Platonic relationship” jokes aside, I guess he was too busy philosophizing. Great men (and women) who can’t slow down to raise a family seem to be a type. Is an interest in philosophy (or science, or art, or any other worthy endeavor) that reaches the point where it consumes your life a mental illness? Kierkegaard bites the bullet and admits that the priests and monks who took vows of celibacy were mentally ill by his definition. But I think he has many more bullets of this type to bite. Even if we agree that we should classify Plato as mentally ill, this again seems very different from the practical concept of “this person has mental problems and needs help with them”. 5: Chronic Pain, Panic Attacks, Or, If You Insist, Nightmares Is chronic pain a mental illness? It seems pretty bad. But as long as it doesn’t impede your ability to hunt, gather, or have sex, I think Emil would have to say no. Same with panic attacks, anxiety, etc. If it’s hard to imagine a form of chronic pain that doesn’t impede those things, consider nightmares. These surely don’t impede any daytime activity, but chronic nightmare disorders seem very unpleasant! I think Emil has to bite the bullet that conditions which make people miserable and ruin their lives aren’t mental disorders as long as they don’t affect functioning. 6: Severity In his post, Emil includes a few turns of phrase indicating we can talk about severity - ie some mental illnesses are more severe than others. But by his framing, “severe mental illness” would indicate not schizophrenia and bipolar disorder, but homosexuality and asexuality. After all, schizophrenics are more likely to have children than gays. Again, this is pretty different from the way you want to use words when talking about real-world problems around how to help people with mental problems get better. 7: Is Emil’s Definition Of Mental Illness Itself A Mental Illness? Emil’s crusade to reclassify homosexuality as a mental illness doesn’t sound like it would be very popular in his home country of Denmark. Maybe there are even some nice Danish women who would be willing to date Emil otherwise, but are turned off by his un-PC opinions. Willingness to violate taboos couldn’t have been very helpful in the environment of evolutionary adaptedness. I imagine some distant ancestor of Emil’s standing up in front of the tribe and saying “Me think Bear God stupid and ugly! Me piss on Bear Idol!” Might mean fewer Kirkegaards around today. So is contrarianism a mental illness? I would say no, because it’s a matter of personal choice and serves a valuable social function. I’m not sure what Emil’s answer would be. * * * I don’t want to assert any of these too strongly. Maybe Emil knows something I don’t about the EEA, and can prove that actually ADHD would be maladaptive there, or ephebophilia would get you in trouble. If so, I think that would restore some concordance between our intuitive notion of mental disorders and Emil’s version, but that concordance would be coincidental, not necessary. The next day we might learn some different fact about the EEA that would make the two notions discordant again. So to repeat my claim: mental-disorder-(Emil) and mental-disorder-(Scott) both describe useful concepts, but they’re not the same concept. Mental-disorder-(Emil) is useful for talking about evolutionary genetics; mental-disorder-(Scott) is useful for talking about present day mental health problems and what to do about them. We won’t convince people to literally use the terms “mental-disorder-(Emil)” and “mental-disorder-(Scott)”. So who should keep custody of the current term “mental disorder” and who should have to make up a new word for their thing? I think Emil should have to make up the new word, because: There are a few thousand evolutionary psychologists, and a few hundred million normal people who want to talk about mental disorders for normal reasons (like because they have them).
panic disorder1 mentions across 1 issues

panic disorder is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between January 25, 2023 and January 25, 2023. The archive places it in contexts such as "Panic disorder should be a mental disorder". It most often appears alongside DSM, DSM, DSM-III.

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panic disorder
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January 25, 2023
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You Don't Want A Purely Biological, Apolitical Taxonomy Of Mental Disorders
January 25, 2023 · Original source
Panic disorder should be a mental disorder, and meditative bliss states should not be a mental disorder, even if they involve similar mental feedback mechanisms.
Inline links: even if they involve similar mental feedback mechanisms
Pansexuality1 mentions across 1 issues

Pansexuality is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between January 04, 2023 and January 04, 2023. The archive places it in contexts such as "“Pansexuality!” interjects FTX Risk Management T-Shirt Guy". It most often appears alongside AI Circle, Anthropic, Asana.

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Pansexuality
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January 04, 2023
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January 04, 2023
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Even More Bay Area House Party
January 04, 2023 · Original source
“Pansexuality!” interjects FTX Risk Management T-Shirt Guy. “I knew it!”
“No, pansexuality is real,” says the Offensiveness Consultant. Then he frowns: “At least, I think it is. It’s not one of ours. But to be honest, I have no idea how many people are playing this game. Sometimes I wonder if they’re all made up by different tech PR firms, mirrors reflecting mirrors.”
PANSS1 mentions across 1 issues

PANSS is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between July 18, 2024 and July 18, 2024. The archive places it in contexts such as "will police be walking around administering the PANSS to everyone they see in a tent?". It most often appears alongside Access Pass, Africa, America.

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PANSS
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July 18, 2024
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July 18, 2024
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Highlights From The Comments On Mentally Ill Homeless People
July 18, 2024 · Original source
People think that “asylums” solve this because you just have to prove that someone is mentally ill. But this is also hard (will police be walking around administering the PANSS to everyone they see in a tent?) and under the existing systems you have to prove some additional point about danger. Even with the recent Supreme Court Grant’s Pass decision, there are a hundred finicky laws and precedents determining who you can and can’t arrest and for how long. I would like to see whether your plan involves pretending these don’t exist, or a concerted campaign to bring each one to the Supreme Court and overturn them, or what.
panther1 mentions across 1 issues

panther is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between April 12, 2021 and April 12, 2021. The archive places it in contexts such as "Before Europeans applied the word “panther” to the big cat found in Asia / the Americas". It most often appears alongside A Whirlwind Tour Of Ethereum Finance, Agan, Air Force Chapel.

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panther
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April 12, 2021
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April 12, 2021
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Links For April
April 12, 2021 · Original source
16: Before Europeans applied the word “panther” to the big cat found in Asia / the Americas, it was a mythical animal akin to the chimera or pegasus (its name comes from pan+therion, “all animals”, and it was probably originally one of those “head of an X, body of a Y, tail of a Z” deals). Read more here, but mentioning this at all is an excuse to show you this picture of a mythical panther from the heraldry of Henry VI:
Inline links: here, heraldry of Henry VI
Paper Belt1 mentions across 1 issues

Paper Belt is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between March 23, 2023 and March 23, 2023. The archive places it in contexts such as "The Paper Belt - Gibson’s term for these extractors". It most often appears alongside 1517, a priori truths, Abraham Lincoln.

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Paper Belt
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March 23, 2023
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March 23, 2023
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Book Review: Paper Belt On Fire
March 23, 2023 · Original source
An advertisement for the author’s hedge fund Michael Gibson’s memoir Paper Belt On Fire succeeds on all counts. The year was 2007. Gibson had just dropped out of Oxford (grad student, philosophy), and applied for a job with the CIA. His secret reason: when he was one year old, his father had admitted to his mother that he was a spy and might be in danger. Before he could tell her anything else, he was found dead, apparently of a heart attack. He thought maybe if he worked at the CIA, he would have access to more information about what happened. The CIA evaluated him (along with a telephone interview, an “IQ test, a personality test, a statement of values, [and] a set of essay questions”) and rejected him. Gibson got a job as an editorial assistant at a tech magazine and blogged on the side. Some of his blog posts came to the attention of Peter Thiel, who offered him a job at his hedge fund. Wasn’t it a bit bold to offer an Oxford philosopher a hedge fund job? Yes, the book mentions how brave and radical and unconventional Thiel’s hiring policies are about twice per paragraph. For example: The media consistently gets Peter wrong . . .The Atlantic’s George Packer wrote . . . that Peter’s hedge fund had the reputation of being a “Thiel cult” that was “staffed by young libertarian brains who were in awe of their boss, emulating his work habits, chess-playing, and aversion to sports.” Packer is a great writer, but in this he was dead wrong, as anyone actually working on the desk knew. Sure, Patrick “the Wolf Man” Wolff was technically a chess grandmaster, ranked higher than Peter, but hardly anyone else ever played. More importantly, the Wolf Man was a diehard Krugman Keynesian. Woersching was a lefty, too, an ardent fan of the egalitarian philosophy of John Rawls. And Josh, he was a dirt-road California Democrat who was a downhill ski junkie […] In truth, Peter didn’t hire just libertarians. He hired scapegoats who’d survived a mob. People who felt comfortable being a minority of one. Thiel in no way selects employees who agree with all of his controversial libertarian opinions. But, by total coincidence, Michael Gibson does agree with all of Peter Thiel’s controversial libertarian opinions. He writes about Cardwell’s Law; historian Donald Cardwell noted that no country remains on the cutting edge for long. During the early Renaissance, Italy was where it was at; a century later, it was Spain and Holland; later still, Britain and Germany, and now new discoveries and businesses come disproportionately from the United States. Why? Gibson and Thiel think that innovation is a rare and fragile plant, which thrives only in the hidden cracks between power structures. Established structures either stamp it out as a threat, or rent-seek off of it so hard that they bleed it dry. Wherever it succeeds, it has succeeded through weird quirks that prevent fat cats from parasitizing it to death. Hong Kong’s economic miracle was during the administration of John Cowperthwaite, an eccentric British libertarian who refused to collect economic statistics because he thought they would make it too easy for meddlers to extract value. America’s economic miracle happened because of a vast frontier - which not only provided freedom for westerners, but served as a BATNA for easterners, preventing their own institutions from sucking them too dry. Now the frontier has closed. New York City recently abandoned its attempt to build a light rail line to the airport: after reaching a $2.4 billion price tag and spending eight years in the planning phase, the government realized it wouldn't be able to overcome all the legal hurdles necessary to grant itself permission. The San Francisco Chronicle reported that it requires 87 permits, two to three years, and $500,000 to get permission to build houses in SF - and your plan might still get shot down because a planning commissioner thinks its glass windows are “a statement of class privilege”. The cracks have shut; the rare fragile plant has been shredded by a combine harvester. Gibson, like Thiel, is a believer in the Great Stagnation - the theory that we’re already reaping the consequences of our newly parasitic society. The early 20th century gave us cars, airplanes, electricity, and penicillin; the early 21st has so far given us some truly excellent social media sites but not much else. Innovation in the world of bits - unbound by geography, comparatively hard to regulate or extort - has sort of continued; innovation in the world of atoms has ground to a halt. And Gibson, like Thiel, talks like a man on a mission. What is good in man thrives only in a few tiny cracks, easily found and destroyed. The last crack was closed within living memory, but its legend hasn’t completely died; the few people who managed to pick up a little of its lore are racing against time to open a new crack before it is entirely forgotten and their project is left to the vicissitudes of history. The cover of “Paper Belt On Fire” goes hard. And yes, the “money” part is a reference to Bitcoin. Gibson’s heart was originally in charter cities - asking some government to open a tiny controlled crack in a sliver of its territory, promising it more meat in the end if it lets its victims grow fat and healthy than if it strangled them in the cradle. But for whatever reason they thought the time wasn’t ripe (the right time, apparently, would be 2019). Instead, Thiel asked Gibson to work on what would become the Thiel Fellowship. He teamed up with Danielle Strachman, a dangerously-hippie-adjacent burnt-out former charter school principal. Their plan was simple: offer talented kids $100,000 to drop out of school and do something exciting in the real world (usually start a company). Paper Belt spends long pages on the hate they got. Larry Summers called it “the single most misdirected bit of philanthropy this decade”. Journalist Jacob Weisberg said anyone who accepted the Fellowship would “halt their intellectual development at the onset of adulthood, maintaining a narrow-minded focus on getting rich as young as possible and thereby avoid the siren lure of helping others or pursuing knowledge for its own sake” (this was before journalists decided that helping others was also evil). Others focused on how there was no way any of these young people would possibly succeed or make money - when the first batch of Thiel fellows failed to revolutionize the world within one year, journalist Vivek Wadhwa wrote Billionaire’s Failed Education Experiment Proves There’s No Shortcut To Success. In fact (slightly conflating the part with the Fellowship with its successor fund): The press . . . hated us. In a 2016 New York Times op-ed, science journalist and author Tom Clynes claimed that “radical innovation has yet to emerge” from anything related to the Thiel Fellowship, and that “the biggest hits have been the most pedestrian.” Antonio Garcia Martinez, the author of the Silicon Valley memoir Chaos Monkeys, spewed forth his bile for us on social media: “For fans of ironic stupidity, Silicon Valley is a never-ending feast”, he wrote on Facebook. He went on to explain, with great vulgarity, why our fund would fail by backing young dropouts. My favorite . . . has to be the challenge issued by Scott Galloway, a professor and bloviator in marketing from NYU’s business school . . . who told Business Insider that if he picked ten smart recent graduates from his alma mater, the University of California at Berkeley, they would outperform any ten dropouts we worked with on some dimension of success related to income or startup formation. Of course he wouldn’t have written the book if any of these people had been right. I can’t find a list of all Thiel fellows, but there are ~20 per year and it’s been running about 12 years, so maybe 200 - 250? At least eight have founded companies valued at over a billion dollars, and others have become impressive philanthropists, activists, and scientists. Pretty good success rate. Gibson argues it’s not about the money, it’s about the mission. We’ve told young people they can’t succeed without the stamp of approval from big institutions. In order to get that stamp, they sacrifice their childhood on the altar of doing things that look nice to admissions officials, then go deep into debt to pay ruinous tuitions. All to waste four years of their lives listening to some professor drone on about post-colonial gender relations in Harry Potter so they can satisfy their gen ed requirement so they can learn the stuff they want to learn so they can get hired by McKinsey so that one day they can be cool and important enough to make a difference in the world. Why not tell young people they can just make the difference right now, without doing any of that? It’s not about the money - but when your graduates are routinely founding billion dollar companies, you’d be crazy to keep it that way. After a few years, Gibson and Strachman noticed the billion-dollar-bill lying on the ground, left the Thiel Fellowship, and started a new VC fund, 1517 (named after the year Martin Luther did some institution-challenging of his own). Their business plan was to do roughly the same thing as the Thiel Fellowship - only this time, invest in the companies beforehand (the parting with Thiel seems to have been amicable; he invested $4 million). So Gibson adopted the life of a venture capitalist. He talks frankly about the difficulties. For example, in one case he found someone nobody else believed in, gave them enough money to keep going, and helped them start their company in exchange for them giving Gibson a certain stake. After the company succeeded, Gibson accuses bigger VC firm Sequoia Capital of convincing the founder to kick him out, and stealing his stake. He says that in the world of VCs it’s poison to sue founders for any reason, so nobody can enforce contracts, so if your founders defect to a different VC for more money, there’s nothing you can do (this is not legal advice). Also, “please give me millions of dollars so I can invest it in college dropouts” is a tough sale for everyone except Peter Thiel. Still, he got a bit of money and tried his best. He takes as his - would it be insensitive to say “role model”? - John Walker Lindh, the American who defected to the Taliban (and who he apparently looked like). Probably it depends on the angle or something. Lindh was the only American to find Osama bin Laden in the early 2000s - he went to lots of jihadi training camps in the process of learning how to jihad, and Osama happened to be at one of them. The lesson, Walker says, is that if you want to find people who are hard to find, you need to steep yourself in their culture, truly understand them, become one with them. Good founders are hard to find. But he and Strachman went to dozens of dingy college dorms, math competitions, group houses, and hackathons, looking for people with the right sort of talent. After pooh-poohing IQ (“Marilyn vos Savant is listed as having the highest recorded IQ, and what does she do? She writes a column for a Sunday supplement in the newspaper”) he lists some of his own preferred metrics for judging would-be Thiel fellows and founders: Polytropon - a famously untranslatable Greek word (“of-many-turns”? “always-has-a-trick-up-his-sleeve” “clever bastard”?) used to describe Odysseus. Edge control - willingness to constantly surf the boundary between order and disorder Crawl-walk-run - ability to scale from a tiny startup to a big company. …and several others, including “tensive brilliance” and “Friday night Dyson sphere”. He and Danielle searched the country for people with these qualities, annoying colleges (he was banned from MIT after showing up too often to convince their students to drop out) and doing various stunts (on October 31 2017, the 500th anniversary of Luther’s theses, he nailed a list of anti-formal-education theses to the doors of the admin buildings of top colleges (“Our commercial printer had misunderstood our request and printed them on seven-foot-long scrolls. They were ridiculous . . . but it turned out for the best.”) At one point, he negotiated with a brilliant 21 year old who may have discovered a transformative diabetes therapeutic, but the hidebound conformist novelty-hating establishment refused to work with him just because he liked the Marvel Cinemat - okay, fine, he may have legally changed his name to “Tony Stark”. Still, Gibson saw past his eccentricities, helped him start his company, and gave him sage advice (he should introduce himself to other investors as “Anthony”). Skip through several more chapters of everyone hating Gibson and telling him he was wrong and refusing to give him money and cheating him out of the money he already had, and the payoff is Luminar. One of the dropouts they cultivated founded a beyond-cutting-edge lasers-for-self-driving-cars company which went public at $3 billion. 1517 made $200 million from the deal - it sounds like they had only ever raised about $25 million, so their investors must have octupled their money on that company alone. Everyone involved is now very rich, and Gibson considers his anti-education thesis on the way to being proven. The book ends with a newly-resourced Gibson continuing his quest to figure out whether and why the CIA killed his father, but it’s slow going. If any of you know a guy named Albert van Dam in Amsterdam, or how to convince Swiss banks to reveal secret account information, get in touch with him. II. A common pattern: I assert something. Everyone yells at me and tells me I’m wrong and stupid, sometimes in very colorful language. I wait, time proves me right, and I write an essay gloating educating people about this. The median comment is “of course this is true, nobody ever denied this was true, why are you wasting our time with something obvious?” I hate this and I try to avoid doing it to other people. This is too bad, because I’m tempted to say: obviously talented dropouts can start good companies. We’ve known this at least since Bill Gates dropped out of Harvard in 1975 to start Microsoft. But also, obviously they can. Brilliant and driven people can succeed whether they get a college education or not. If Bill Gates had stayed an extra two years at Harvard, he probably would have taken a few more advanced math classes not really related to programming software or running a company. So why should we even have as a hypothesis that he couldn’t start Microsoft successfully without doing that? Still, Gibson adequately proves that lots of people hated him and were sure he would fail. Either we should read this backwards - learn that there was once a time when pro-college messages were even stronger than now, so strong that people thought it was literally impossible to succeed without every single day of a four-year college application - or the critics were trying to get at something deeper they were bad at expressing. For example: what, exactly, is Gibson’s alternative to the education system? The back-of-book-blurb says Paper Belt On Fire is about “how higher education and other institutions must evolve to meet the dire challenges of tomorrow” - but evolve how? What exactly has been proven here? A few of the very brightest young people, hand-picked by an expert young-person-picker and given $100K, can become billionaires or make great discoveries without a college degree. What are the implications? Suppose you are an average college student with an average level of talent and motivation. Should you drop out and try to create a company for Peter Thiel? Based on how many average-talent people Thiel rejects, even he doesn’t think you should do that. And if you don’t have a good answer to this question - the one relevant to 99.9% of education system inmates - have you really launched a challenge to the educational system? Gibson doesn’t address this question, but I predict he would admit that, fine, he doesn’t have an alternative to the education system in the sense of “educate people this way rather than that way”. He just wants less formal education, and has proven this will work fine. True, he’s only proven it for a tiny subset of ultra-talented people. But “billionaire tech founder” is a hard job - if it wasn’t, more people would do it and reap the $1 billion reward. Proving that people can become billionaire tech founders without college degrees implicitly suggests they can be successful middle managers or budget analysts without college degrees. So the sort of companies that need middle managers and budget analysts should also consider hiring people without degrees, and the sorts of average-level-of-talent-and-motivation people who want these jobs should consider skipping college. Would this work? Probably. It worked in the early 1900s, when only 5-10% of Americans had college degrees but the country seemed about as dynamic and successful as it does now. It worked for people like George Washington, Abraham Lincoln, and Thomas Edison, none of whom went to college. It works in other countries - for example in the UK where young doctors skip undergrad and go straight to medical school, and whose patients get about the same outcomes as in the US. It works for people with impractical degrees like philosophy, who are constantly getting jobs in (and doing well in) fields that don’t require you to compare Locke vs. Leibniz’s perspective on a priori truths. So this would work if everyone agreed to do it at once, which they won’t. The way college gets you is adverse selection. Suppose that tomorrow, you - a smart and hard-working person who could easily get a college degree - decline to do so, because you appreciate Peter Thiel and Michael Gibson’s anti-institutional perspective. The pool of people without college degrees is now, to a first approximation: 200 million people who weren’t smart to get in, rich enough to afford it, or motivated enough to finish.
Inline links: Paper Belt On Fire, John Cowperthwaite, recently abandoned its attempt, reported that, might still get shot down because, https://substackcdn.com/image/fetch/$s_!XcvP!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fa8b369ca-5089-4e18-857d-1f34a9eee200_585x134.png, 2019, journalists, decided, that, Billionaire’s Failed Education Experiment Proves There’s No Shortcut To Success, https://substackcdn.com/image/fetch/$s_!R2y6!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F38012394-be90-413c-b9a2-c291f1b3a118_858x392.png, his company, read this backwards
Probably it depends on the angle or something. Lindh was the only American to find Osama bin Laden in the early 2000s - he went to lots of jihadi training camps in the process of learning how to jihad, and Osama happened to be at one of them. The lesson, Walker says, is that if you want to find people who are hard to find, you need to steep yourself in their culture, truly understand them, become one with them. Good founders are hard to find. But he and Strachman went to dozens of dingy college dorms, math competitions, group houses, and hackathons, looking for people with the right sort of talent. After pooh-poohing IQ (“Marilyn vos Savant is listed as having the highest recorded IQ, and what does she do? She writes a column for a Sunday supplement in the newspaper”) he lists some of his own preferred metrics for judging would-be Thiel fellows and founders: Polytropon - a famously untranslatable Greek word (“of-many-turns”? “always-has-a-trick-up-his-sleeve” “clever bastard”?) used to describe Odysseus. Edge control - willingness to constantly surf the boundary between order and disorder Crawl-walk-run - ability to scale from a tiny startup to a big company. …and several others, including “tensive brilliance” and “Friday night Dyson sphere”. He and Danielle searched the country for people with these qualities, annoying colleges (he was banned from MIT after showing up too often to convince their students to drop out) and doing various stunts (on October 31 2017, the 500th anniversary of Luther’s theses, he nailed a list of anti-formal-education theses to the doors of the admin buildings of top colleges (“Our commercial printer had misunderstood our request and printed them on seven-foot-long scrolls. They were ridiculous . . . but it turned out for the best.”) At one point, he negotiated with a brilliant 21 year old who may have discovered a transformative diabetes therapeutic, but the hidebound conformist novelty-hating establishment refused to work with him just because he liked the Marvel Cinemat - okay, fine, he may have legally changed his name to “Tony Stark”. Still, Gibson saw past his eccentricities, helped him start his company, and gave him sage advice (he should introduce himself to other investors as “Anthony”). Skip through several more chapters of everyone hating Gibson and telling him he was wrong and refusing to give him money and cheating him out of the money he already had, and the payoff is Luminar. One of the dropouts they cultivated founded a beyond-cutting-edge lasers-for-self-driving-cars company which went public at $3 billion. 1517 made $200 million from the deal - it sounds like they had only ever raised about $25 million, so their investors must have octupled their money on that company alone. Everyone involved is now very rich, and Gibson considers his anti-education thesis on the way to being proven. The book ends with a newly-resourced Gibson continuing his quest to figure out whether and why the CIA killed his father, but it’s slow going. If any of you know a guy named Albert van Dam in Amsterdam, or how to convince Swiss banks to reveal secret account information, get in touch with him. II. A common pattern: I assert something. Everyone yells at me and tells me I’m wrong and stupid, sometimes in very colorful language. I wait, time proves me right, and I write an essay gloating educating people about this. The median comment is “of course this is true, nobody ever denied this was true, why are you wasting our time with something obvious?” I hate this and I try to avoid doing it to other people. This is too bad, because I’m tempted to say: obviously talented dropouts can start good companies. We’ve known this at least since Bill Gates dropped out of Harvard in 1975 to start Microsoft. But also, obviously they can. Brilliant and driven people can succeed whether they get a college education or not. If Bill Gates had stayed an extra two years at Harvard, he probably would have taken a few more advanced math classes not really related to programming software or running a company. So why should we even have as a hypothesis that he couldn’t start Microsoft successfully without doing that? Still, Gibson adequately proves that lots of people hated him and were sure he would fail. Either we should read this backwards - learn that there was once a time when pro-college messages were even stronger than now, so strong that people thought it was literally impossible to succeed without every single day of a four-year college application - or the critics were trying to get at something deeper they were bad at expressing. For example: what, exactly, is Gibson’s alternative to the education system? The back-of-book-blurb says Paper Belt On Fire is about “how higher education and other institutions must evolve to meet the dire challenges of tomorrow” - but evolve how? What exactly has been proven here? A few of the very brightest young people, hand-picked by an expert young-person-picker and given $100K, can become billionaires or make great discoveries without a college degree. What are the implications? Suppose you are an average college student with an average level of talent and motivation. Should you drop out and try to create a company for Peter Thiel? Based on how many average-talent people Thiel rejects, even he doesn’t think you should do that. And if you don’t have a good answer to this question - the one relevant to 99.9% of education system inmates - have you really launched a challenge to the educational system? Gibson doesn’t address this question, but I predict he would admit that, fine, he doesn’t have an alternative to the education system in the sense of “educate people this way rather than that way”. He just wants less formal education, and has proven this will work fine. True, he’s only proven it for a tiny subset of ultra-talented people. But “billionaire tech founder” is a hard job - if it wasn’t, more people would do it and reap the $1 billion reward. Proving that people can become billionaire tech founders without college degrees implicitly suggests they can be successful middle managers or budget analysts without college degrees. So the sort of companies that need middle managers and budget analysts should also consider hiring people without degrees, and the sorts of average-level-of-talent-and-motivation people who want these jobs should consider skipping college. Would this work? Probably. It worked in the early 1900s, when only 5-10% of Americans had college degrees but the country seemed about as dynamic and successful as it does now. It worked for people like George Washington, Abraham Lincoln, and Thomas Edison, none of whom went to college. It works in other countries - for example in the UK where young doctors skip undergrad and go straight to medical school, and whose patients get about the same outcomes as in the US. It works for people with impractical degrees like philosophy, who are constantly getting jobs in (and doing well in) fields that don’t require you to compare Locke vs. Leibniz’s perspective on a priori truths. So this would work if everyone agreed to do it at once, which they won’t. The way college gets you is adverse selection. Suppose that tomorrow, you - a smart and hard-working person who could easily get a college degree - decline to do so, because you appreciate Peter Thiel and Michael Gibson’s anti-institutional perspective. The pool of people without college degrees is now, to a first approximation: 200 million people who weren’t smart to get in, rich enough to afford it, or motivated enough to finish.
Inline links: his company, read this backwards
Until Gibson has an answer for this, all his anti-education rhetoric feels like potshots. Some of those potshots will land, the ogre will howl in pain, and it will be very satisfying. But in the end it’s still an ogre, it’s still stronger than you, and you still owe it $30,000 for every year you or your children are between ages 18-22 - which it will take and distribute among all of the usual types of people who populate extractive institutions and extract from them in turn. The Paper Belt - Gibson’s term for these extractors - is at best barely smoldering.
paperclip maximizer1 mentions across 1 issues

paperclip maximizer is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between May 08, 2023 and May 08, 2023. The archive places it in contexts such as "Doesn’t the superintelligent paperclip maximizer know that you didn’t mean for it to turn the whole world into paperclips?". It most often appears alongside Anthropic, Cognitive behavioral therapy, Constitutional AI.

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paperclip maximizer
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Constitutional AI: RLHF On Steroids
May 08, 2023 · Original source
This gets to the heart of a question people have been asking AI alignment proponents for years: if the AI is so smart, doesn’t it already know human values? Doesn’t the superintelligent paperclip maximizer know that you didn’t mean for it to turn the whole world into paperclips? Even if you can’t completely specify what you want, can’t you tell the AI “you know, that thing we want. You have IQ one billion, figure it out”?
Inline links: if the AI is so smart, doesn’t it already know human values
Paperclipalypse1 mentions across 1 issues

Paperclipalypse is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between January 30, 2024 and January 30, 2024. The archive places it in contexts such as "In “Paperclipalypse” or “AI Doom,” we again think of future AIs as a superintelligent “alien race”". It most often appears alongside 538, Aaronson, ACX.

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24
January 30, 2024 · Original source
Paperclipalypse. In “Paperclipalypse” or “AI Doom,” we again think of future AIs as a superintelligent “alien race” that doesn’t need humanity for its own development. Here, though, the AIs are either actively opposed to human existence or else indifferent to it in a way that causes our extinction as a byproduct. In this scenario, AIs do not develop a notion of morality comparable to ours or even a notion that keeping a diversity of species and ensuring humans don’t go extinct might be useful to them in the long run. Rather, the interaction between AI and Homo sapiens ends about the same way that the interaction between Homo sapiens and Neanderthals ended.
I think Paperclipalypse requires human extinction before 2050. It’s at 11%. But Metaculus’ direct “human extinction by 2100” market is only at 1.5%. Either I’m missing something, or something’s wrong. My guess: different populations of forecasters looking at each question.
Inline links: “human extinction by 2100”
Paraclete1 mentions across 1 issues

Paraclete is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between November 17, 2023 and November 17, 2023. The archive places it in contexts such as "Paraclete, the Greek word for the Holy Spirit, originally meant 'defense attorney'". It most often appears alongside Abel, Adam and Eve, America.

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Paraclete
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Book Review: I See Satan Fall Like Lightning
November 17, 2023 · Original source
(and did you know that Paraclete, the Greek word for the Holy Spirit, originally meant “defense attorney”? The Paraclete is the force that - no, we’ll get to that later).
Paradox1 mentions across 1 issues

Paradox is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between June 10, 2022 and June 10, 2022. The archive places it in contexts such as "Paradox in a curt section". It most often appears alongside 50,000 BC, Africa, Altamira.

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Your Book Review: The Dawn Of Everything
June 10, 2022 · Original source
So yes, I think the Davids are right on this as well: there is at least suggestive evidence of a period of time, particularly around or right after 10,000 BC, of what might be called political experimentation by prehistorical humans. These nascent governments and formal systems of law and order might not have been taken all that seriously at first, more theatrical and seasonal in nature, until, slowly, as John Updike said, “the mask eats the face.” THE SAPIENT PARADOX AS AN ANCIENT ANALOG TO THE FERMI PARADOX, AND THE GREAT TRAP OF PREHISTORY IT IMPLIES Almost everything we’ve talked about so far, with the exception of the mammoth houses and some remains of gathering places, takes place after 10,000 BC. It’s really only in the Upper Paleolithic (12,000-5,000 BC) that there is any good evidence for what we would call civilization, with its associated lavish burials and monumental centers of ritual congregation and pilgrimage and trade networks and specialization of tribes toward certain industries, and it is only at this point that complex representation in art becomes essentially universal.
This is a striking mismatch: let’s say modern humans genetically (mostly) and physically (definitely) were around 100,000 years ago: why does it take 90,000 years to get Göbekli Tepe? This perplexing question is called the “Sapient Paradox.” Colin Renfrew, the coiner of the Sapient Paradox, describes it as a
Inline links: describes it
puzzling aspect, which I call the Sapient Paradox. . . we can see in the archeological record. . . the appearance of our own species, Homo Sapiens, about 100 or 150,000 thousand years ago in Africa, and we can follow the out-of-Africa migrations of our species, Homo sapiens, 60-70,000 years ago. . . Apart from the episode of cave art, which was very much limited to Europe and a bit further on to Asia, not a great deal happened until about 10,000 years ago. . . modern genetics has made clear that our genetic composition, speaking in general. . . is very similar to the genetic composition to our ancestors in Africa of about 70,000 years ago.
Parallel Lives1 mentions across 1 issues

Parallel Lives is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between November 01, 2024 and November 01, 2024. The archive places it in contexts such as "a simple 19-card combination of Parallel Lives". It most often appears alongside /r/BadMTGCombos, @cremieuxrecuel, @justin_garson.

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Links For November 2024
November 01, 2024 · Original source
Here the black line indicates that the average European of 6000 BC would have had genetic IQ 65 (compared to modern 100), but the regression line indicates more like IQ 90 - I don’t know why the researchers chose to interpret the trend as necessarily constant and linear, or whether we should follow. There isn’t enough ancient DNA to fully test whether the same happened in other populations yet, although a preliminary small-sample test on Asians suggests it happened there too (not really, see here). If the selection for IQ was a response of agriculture, we’d expect to see higher genetic IQ in populations that got agriculture earlier. But it could also be a response to sentience itself creating new selection pressures that continued to act as recently as historical time (some evidence suggests this is true of schizophrenia), which might make populations more similar. 7: Joseph Heath on Marxism vs. John Rawls. I appreciated this because everyone knows we’re supposed say that John Rawls is among the most important philosophers of all time blah blah blah but nobody had ever explained why to me (veil of ignorance seems neither very original nor very good). Heath’s answer: Marxism dominated the academy for decades, but eventually became philosophically unsustainable. This wasn’t because of the generic “Communism doesn’t work” objections that moved ordinary people. It was because Marx’s ethical critique of capitalism was based on exploitation, according to a technical definition of “exploit” that only made sense according to Marx’s labor theory of value. But the supply-and-demand theory of value quickly supplanted the labor theory, the exploitation argument doesn’t really work within supply-and-demand, and so Marxist philosophers were left without a clear ethical critique. John Rawls, by coming up with the part of the underpinning for the modern inequality-based-critique of society, let all the Marxist academics switch to being liberals while continuing to dislike capitalists. 8: /r/BadMTGCombos: a simple 19-card combination of Leyline of Anticipation, Leyline of Transformation, Mirror Room, Darksteel Citadel, Sanctum Weaver, Freed From The Real, Abuelo's Awakening, Myrkul Lord of Bones, Zimone All Questioning, Birgi God of Storytelling, Siege Zombie, Desecration Elemental, Mirror Gallery, Clock of Omens, Parallel Lives, Life and Limb, Isochron Scepter, Narset's Reversal, and Molten Reflection can be used to deal infinite damage if and only if the Twin Prime Conjecture is true. 9: During the most recent Berkeley ACX meetup, we somehow ended up discussing how often people feed living mice to snakes. The answer seems to be that there’s a debate about it in the snake community, the smartest and most experienced voices are against it, but it still happens a lot. Here’s an EA Forum post on the feeder rodent industry and efforts to make it more humane. 10: King Frederick William I of Prussia decided to have a regiment of giants in his army and scoured Europe for extremely tall people, including poaching them from other countries’ armies and forcing them to enlist against their will. He ended up with 3,000 soldiers, ranging from 6’2 - 7’6, but “many of the men were unfit for combat due to their gigantism”. So why did he do it? He liked to paint their portraits from memory. He tried to show them to foreign visitors and dignitaries to impress them. At times he would try to cheer himself up by ordering them to march before him, even if he was in his sickbed. This procession, which included the entire regiment, was led by their mascot, a bear. He once confided to the French ambassador that "The most beautiful girl or woman in the world would be a matter of indifference to me, but tall soldiers—they are my weakness" The King dreamed of a eugenics program to create even taller soldiers. He got as far as pairing up some of his tall soldiers up with tall women and birthing a few tall babies before he died; his successor had no interest and let everybody go home. 11: Before modern IP law, you could write a sequel to someone else’s book and they couldn’t stop you. Among the most successful examples is American “astronomer and writer” Garrett Serviss’ Edison’s Conquest Of Mars, a sequel to War Of The Worlds in which a vengeful human race, led by Thomas Edison, invent spaceships and attack Mars in retaliation for the first book’s Martian invasion. "The book contains some notable 'firsts' in science fiction: alien abductions, spacesuits, aliens building the Pyramids, space battles, oxygen pills, asteroid mining and disintegrator rays", and was credited as an inspiration by Robert Goddard and HP Lovecraft. 12: Joe Biden, singularitarian? (click for link to video) 13: Gwern on the chip embargo: It is pretty damning. We're told the chip embargo has failed, and smugglers have been running rampant for years, and China is about to jump light years beyond the West and enslave us with AXiI (if you will) . . . And then an expert casually remarks that all of China put together, smuggling chips since 2022, has fewer H100s than Elon Musk orders for his datacenter while playing Elden Ring. And even with that huge bottleneck and 1.4 billion people, there's so little demand for them that they cost less per hour than in the West, where AI is redhot and we can't get enough H100s in datacenters. (And where the serious AI people are now discussing how to put that many into a single datacenter for a single run before the next scaleup with B200s obsoletes those...) 14: A company called Cosm has raised $250 million to build “immersive sports experiences”, ie giant buildings sort of like a cross between a stadium and a movie theater where people can get together and watch high-quality televised sports games in a “realistic” setting; they already have facilities in Dallas and Los Angeles. 15: Cremieux: The Ottoman Origins Of Modernity. The “Ottoman” bit is a distractor; the Ottomans fought the Catholics long enough for the Protestants to get a foothold, and then the Protestants established modernity. A useful pushback against the pushback that the Catholic Church never persecuted scientists or held back progress. I’m most interested in this post in the context of Cremieux saying he wrote it in two hours. Even I can’t work that fast! 16: The Green Party, a US third party, tried to put their candidate Jill Stein on the ballot in November. The Nevada election office sent them the wrong forms and gave them false advice about the process. The Greens filed the wrong forms, the Democrats sued, and the Supreme Court disqualified Stein, calling the election office’s incorrect advice an “unfortunate mistake”. I’m disappointed in this outcome - partly for the obvious reasons, but also because the incorrect forms they submitted technically should have added a state referendum to the ballot containing only the text “Jill Stein”. If they’re going to disqualify her candidacy, then I think they should at least hold the state referendum! 17: Nostalgebraist: Google has a new tool out that will create an AI podcast for any text; you hand it the text (could be a blog post, article, or work of fiction), and the tool generates a podcast of two AI hosts discussing it. You can find podcast discussions of Nostalgebraist’s fiction (Northern Caves and Almost Nowhere) at the link, but the acknowledged peak of the genre is Podcast Hosts Discover They’re AI, Not Human, And Spiral Into Existential Meltdown. 18: Also Nostalgebraist: The Case For Chain Of Thought Unfaithfulness Is Overstated. New AIs like o1 give “chain of thought”, ie display what they’re thinking after each step. This seems like a promising avenue to solve alignment - just see whether they’re thinking “and now I will plot against humans”. Unfortunately it’s not so easy; the chain of thought isn’t always accurate (you can sometimes catch the AI “hiding” thoughts it doesn’t want its human overseers to know, like when it’s using a racial stereotype). This article argues that these examples aren’t as exciting as they sound, and chain-of-thought accurately reflects reasoning for most tasks. 19: Australian government considers making doxxing a crime punishable by up to seven years in jail. 20: Getting your brain cryogenically frozen after your death is now free. 21: Cube Flipper: Hypercomputation without bothering the cactus people. The visual system must solve difficult math problems when translating the 2D visual field into a 3D world. Can we harness this innate mathematical ability to do arbitrary work? Cognitive scientist Mark Changizi developed a series of visual circuits (eg XOR gates) based on Necker cubes, probably easier seen than described: After surveying the field, Cube Flipper proposes a more advanced visual computer based on taking DMT and viewing certain types of tiles with slight deviations: …and makes the extreme claim that something like this might demonstrate hypercomputation, ie the visual system has semi-magic computational properties beyond those permitted by normal physical laws. I am skeptical but appreciate the survey of visual computing (as well as the callback to one of my older posts). 22: Material implication in Mormonism: In the book Doctrines and Covenants, Joseph Smith reports that God told him that if he lived to be 85, he would see the Second Coming (which would place it in 1890 - 1891). Mormon apologists note that Joseph Smith did not live to be 85, so no conclusion can be drawn. 23: More old-timey psychiatric ads (this one is from 1952, source: @justin_garson): This was before they invented what we would call antidepressants today; Dexedrine is an amphetamine related to Adderall. 24: Congratulations to Open Philanthropy, the biggest effective altruist foundation… …whose grantee David Baker recently won a Nobel Prize for his research on synthetic proteins. Potential applications include new drugs, vaccines, and materials. 25: Rich Kid Memes And The Online Culture Of The One Percent. Rich people who want to signal group membership to other rich people online can’t boast about how rich they are; that would be gauche. Instead, they’ve settled on the solution of making fun of rich people in hyperspecific language that proves familiarity with the culture. 26: Tap Water Sommelier: Vladimir Putin has two sons, ages 5 and 9. They are kept in luxurious but total isolation from the outside world and raised by flunkies who are too scared to punish/restrain them in any way. Also some discussion of an unexpected historical analogue. 27: Experiment from Colombia: replacing experienced teachers with less-experience but higher-scoring-on-tests teachers significantly decreased student performance. Got to admit I was expecting the opposite of this, I’d seen US data saying that experience didn’t matter and teacher intelligence did. Looking over this more, I find lots of studies on both sides and will go back to agnosticism on this question until someone I trust investigates further. 28: Large scale-formal Intellectual Turing Test finds that people can imitate partisans effectively; ie nobody on either side can tell the difference between a Democrat arguing for Democrat values vs. a Republican-pretending-to-be-a-Democrat arguing for Democrat values (and vice versa). This study used a 100 word essay on why you supported your party (you can see if you can do better here), but past attempts with different structures (religion, vegetarianism, polyamory) have shown broadly the same results. The researchers try to put this in the context of various studies showing that people do misunderstand their opponents (eg think they’re more extreme, underestimate the level of common ground), but it seems like intellectual Turing Tests aren’t a good way to measure or tease out this misunderstanding. 29: Congratulations to Substacker WoolyAI for doing the impossible and providing a genuinely novel and interesting (to me) take on pickup artistry: 30: Did you know: if you Google “cool websites”, our subreddit (r/slatestarcodex) is the first result. 31: Moshe Koppel, who works at the intersection of computer science and Talmud, is writing a series of posts (presumably) based off of my Every Bay Area House Party, titled Jerusalem Area House Party (it’s multiple part, you have to go to the main Substack page to find the others). I won’t necessarily link everyone who riffs off one of my posts - but honestly I probably will if you also have a Wikipedia page that describes you as working on computational Talmudology. 32: David Roman says it’s a myth that Arabic scholars rescued and preserved the works of the great classical authors. 33: Medications often decrease “secondary endpoints” (eg stroke, heart attack), but the holy grail of pharma studies is proving that a certain drug decreases all-cause mortality. This is much harder (not all heart attacks kill people, and people die from lots of other things), but is the strongest possible endorsement for the drug (without it, you might worry that it only prevented non-fatal heart attacks, or that it killed as many people through side effects as it saves through heart attack prevention). Even great medications that we’re confident in can’t always clear this bar. But a new JAMA article adds another member to this select club: Adderall decreases all-cause mortality in ADHD, probably because it prevents drug addiction, car accidents, and impulsive actions. 34: Before the Gulf War got in the way, Saddam Hussein was building some crazy mosques: 35: Italy bans surrogacy - quite strictly, too, Italians aren’t even allowed to go abroad and do it. I am so sorry for all the Italians who will never get to be mothers and fathers because their government hates progress. You might hope that, whatever the other disadvantages of anti-immigrant parties, at least they’re incentivized to let natives have children, but looks like they can’t even get that one right. Starting to wonder whether the trains even run on time. 36: Elsewhere in “Italy sucks” news - did you know Italy’s tax code effectively bans startups? Companies are taxed before making any money, based on how many assets they have. If they have lots of assets but aren’t making money (eg because they’re still doing research / in stealth) then tax officials get confused and hostile and run increasingly punitive audits. Related: size of the European tech sector. It’s the red line on this chart; if you can’t see a red line at your screen resolution, then you’ve learned something important about the the EU tech sector. 37: Seen on @cremieuxrecuel’s twitter (preliminary, needs replication): Jews may have gone from 65-29 Democrat/Republican in 2020 to 58-40 this election. 38: Extelligence has a post responding to my critique of the cultural Christianity argument (among, uh, many other things), but I don’t really think it connects. I’m not telling atheists they can’t go to church/synagogue if it makes them feel happy and fulfilled - I’ve done this myself sometimes. My post was meant to argue against the claim that, for pragmatic reasons, atheists should support the Christianization of society as a defense against Islam or postmodernism or some other philosophical enemy. 39: Related: Extelligence is finally going for their Trust Assembly project/idea/startup for online consensus-based truth-seeking (I think something like a cross between Community Notes and Wikipedia, but as a browser extension, and for everything). He’s looking for potential developers/testers/users. 40: Jiankui He is the Chinese geneticist who made history with the first germline gene editing in humans (resulting in three babies supposedly immune to AIDS, although nobody has tested this). China sentenced him to three years in prison for unauthorized experimentation, but now he’s out of jail, has an English-language Twitter account, has a new lab, wants to work on Alzheimers, and seems pretty based (although not infinitely based): 41: Anthropic has a new version of their AI Claude which can use your computer. You give it permission, put it on a virtual desktop, and ask it to do things for you (eg “please find and download a picture of a cat” or “please research these ten things and put them in a text file”.) It moves your cursor, browses the Internet, and creates and saves files. People keep saying they’ll care about AI “when it operates autonomously” or “when it becomes an agent”. But this is a trivial barrier, and one which Computer Use Claude has arguably already passed. So far this feature is limited to developers (though anyone with computer knowledge can sign up for it) but I expect it to be the near future of consumer AI, to get better quickly, and to shade gradually into the “autonomous” “agentic” AI that you all think will require a paradigm shift. 42: Claim (from the IDF): Hamas faked polls showing that most Palestinians supported the October 7 attack; the real numbers are 31% in favor, 64% against. 43: Otto von Bismarck wanted to trick France into declaring war on Germany. In order to provoke the French, he sent the Ems Dispatch, a statement describing recent diplomatic events in a way that sounded maximally offensive. The French were so offended that “crowds” in Paris demanded war, and the Franco-Prussian War was declared soon afterwards. The part of this that I find most interesting is the text of the dispatch itself, which read: After the news of the renunciation of the Prince von Hohenzollern had been communicated to the Imperial French government by the Royal Spanish government, the French Ambassador in Ems made a further demand on His Majesty the King that he should authorize him to telegraph to Paris that His Majesty the King undertook for all time never again to give his assent should the Hohenzollerns once more take up their candidature. His Majesty the King thereupon refused to receive the Ambassador again and had the latter informed by the Adjutant of the day that His Majesty had no further communication to make to the Ambassador. I’m fascinated by the idea that only 150 years ago, it was obvious that if someone sent you this statement, you had to declare war or abandon all honor. If I read it carefully, I can sort of parse out that it sounds like the Prussians are unhappy, but that’s the most emotion I gather from it. Anyway, the Franco-Prussian War led to World War I which led to World War II - so if you don’t like 50 million people dying and the total devastation of Europe, blame this statement about ambassadors. 44: The first use of artificial insemination in humans: The first recorded case of artificial insemination by donor didn’t occur until 1884, when Dr. William Pancoast decided to treat a couple’s infertility by secretly inseminating the woman with sperm obtained from a medical student. The insemination happened while the patient was under anesthesia and Dr. Pancoast did not tell her what had occurred. She gave birth to a baby boy nine months later, but it was several years before the doctor finally confessed to her husband what he had done. Neither man ever informed the mother. It was 25 years later the result of this case was published. Dr. Pancoast was roundly condemned for his actions, but it did open the door for consensual sperm donor insemination. 45: ClearerThinking administers several personality tests to the same people to learn more about their comparative accuracy. I am most interested in their finding that tests with “factors” (eg the Big Five, where you rate people on a numeric scale) are inherently more accurate than those with “types” (eg Myers-Briggs, where you assign someone a specific category) and that, adjusting for this, Big Five is no more predictive than the Enneagram: 46: In 2022, I wrote Whither Tartaria, where I asked why ornate classical styles switched to more austere modernist styles around 1900 - 1950 in a variety of different arts (painting, architecture, literature, poetry, etc). I proposed seven theories, but was unsure which if any were true. Since then, Samuel Hughes of Works In Progress has been investigating. In May, he wrote a well-researched article showing that it wasn’t just increasing cost, because ornate classical architecture now costs less than ever. Now in a new article he demolishes a different theory - it’s not just decreasing cost (and subsequent lack of ability to signal wealth) - because costs didn’t decrease in several other arts, and the change was led by artists with rich people as reluctant followers. He concludes: Modernism may well be a status game of some kind; it may well signal taste more than it signals wealth; and this latter feature may be one of the things that distinguishes it from older artistic styles. But the mechanism by which this change came about must be different to the one Alexander describes. 47: Sort of kind of related - When Hamilton Lost Its Snob Appeal. The musical Hamilton was briefly an artistic/cultural phenomenon, but tastemakers eventually switched to making fun of it. Why? Rob Henderson says it happened after ticket prices came down and the common people could enjoy it. I disagree: everyone I knew who was into Hamilton got into it from the free online soundtrack long before they’d seen the show; I think this is more likely the usual fad cycle where anybody who’s too into yesterday’s fad is behind the curve and therefore uncool. 48: Related: Why are people such jerks to public intellectuals? And more. I agree this is a great mystery. 49: Some prominent Substack psychiatrists doing a video Q&A, submit your questions here. 50: Naomi Kanakia: The Literacy Delusion had a number of explanations for why reading books seemed to be so much worse for human beings (in terms of emotional wellness and productivity) than other forms of narrative entertainment, but its main theory was the integration hypothesis. That the stream of words in a book trained the human brain into a habit of self-consciousness, that reading books forced human beings to think of themselves as a stream of text, processed through time, making a coherent argument of some sort. And that this overall flattening effect forced readers to ignore aspects of their personality or their situation that were not otherwise in line with the overarching story they'd created about themselves. Basically, reading books causes repression and neurosis. The Literacy Delusion argued that, yes, human beings are storytelling machines, but that a stream of written text is a particular kind of story—a story that is particularly flat, particularly devoid of conflicting or harmonizing information—and that this flatness creates a peculiar effect on the human brain. 51: Last month, I linked Sasha Gusev’s No, Intelligence Is Not Like Height and asked people who disagreed to share their arguments; they sure did. First, several people pointed me to a new preprint, Family-GWAS Reveals Effects Of Environment And Mating On Genetic Associations, which finds that one of the main papers Gusev cited to make his case, Howe 2022, made a mistake - imputing sibling genotypes using a process designed for non-sibling genotypes - and that once that mistake is corrected, the finding disappears and intelligence and height appear similar. Second, Joseph Bronski has a more specific post where he responds to Gusev’s points one by one. He accuses Gusev of “[making] up his own chart to remove the error bars [from the originals], to obscure the fact that the study found no evidence for this in IQ”, and says that the cases where he didn’t do that are just “population stratification and range restriction”. Third, Noah Carl at Aporia, instead of writing a direct response like Bronski, argues that the usual method of attacking twin studies is obsolete; not only have the most-debated assumptions behind twin studies been thoroughly validated, but there are now other lines of evidence besides twin studies which confirm high IQ heritability. Fourth, Leonardo Parro (not framed as a response to Gusev) goes into more depth about one of those ways, a “pedigree-based analysis” demonstrating heritability of 54 - 69%, ie no “missing heritability” compared to twin studies. He summarizes this as the effect of “rare variants” compared to the usual SNPs - ie if you only look at the most common genes that are easiest to find, you get “missing heritability” compared to twin studies, but if you widen your search to rare genes that are hard to find, you don’t. 52: Extremely related: Heliospect is a startup promising polygenic selection for IQ and other traits; they were trying to stay in stealth mode but The Guardian spied on them and nonconsensually revealed their existence. The discussion on the r/ssc subreddit centered on their claim that (given enough embryos to choose from) they could increase a baby’s expected IQ by 6 points (I’ve also heard 7.5). Sasha Gusev had previously argued that current technology maxed out at 3.5 and future technology would max out at 6, so a claim of 6 - 7.5 is pretty extreme; Gwern, who wrote the pioneering analysis of this technology, was also skeptical. But Heliospect says they’ve got better predictors than academia that use the rare variants everyone else misses; after talking to the company, Gwern retracted his objections and says he finds their claim “pretty plausible”. Local ACX commenter geneticist Gene Smith also redid some calculations, changed his mind, and says “probably pretty realistic”. I find this interesting not just because of the polygenic selection angle, but because if Heliospect is right then their predictor is able to predict more genetic IQ than the “missing heritability” people believe exists, and it should be able to put this argument to bed once and for all. 53: This month in censorship: X/Twitter banned journalist Ken Klippenstein for sharing the Trump campaign’s dossier on JD Vance. Twitter’s side of the story is that the dossier was probably originally stolen by Iranian agents and they don’t want to support that kind of thing by letting people signal-boost the illicitly obtained goods; you can read Klippenstein’s side here. He appears to be unbanned now.
Inline links: see here, got agriculture earlier, some evidence suggests this is true of schizophrenia, Marxism, John Rawls, nor very good, /r/BadMTGCombos, can be used, Twin Prime Conjecture, the feeder rodent industry and efforts to make it more humane, decided to have a regiment of giants in his army, Edison’s Conquest Of Mars, click for link to video, Gwern on the chip embargo, Cosm, The Ottoman Origins Of Modernity, sent them the wrong forms and gave them false advice about the process, added a state referendum to the ballot containing only the text “Jill Stein”., Nostalgebraist, Podcast Hosts Discover They’re AI, Not Human, And Spiral Into Existential Meltdown, The Case For Chain Of Thought Unfaithfulness Is Overstated, isn’t always accurate, considers making doxxing a crime, is now free, Hypercomputation without bothering the cactus people, developed, https://substackcdn.com/image/fetch/$s_!FcOr!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fbee8dfa6-4d7b-41c9-972a-5fbaa792b9ec_3566x2888.png, https://substackcdn.com/image/fetch/$s_!x34r!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F413f5fc2-2391-4734-904f-8401dd968488_1024x1024.png, one of my older posts, reports, note, @justin_garson, https://substackcdn.com/image/fetch/$s_!EF4p!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F4b7af4c0-ac0f-4c9a-88bc-6c00e57ca977_479x639.jpeg, https://x.com/albrgr/status/1844527064956928009, won a Nobel Prize, Rich Kid Memes And The Online Culture Of The One Percent, Tap Water Sommelier, Experiment from Colombia, experience didn’t matter, teacher intelligence did, Large scale-formal Intellectual Turing Test, you can see if you can do better here, religion, vegetarianism, polyamory, WoolyAI, https://substackcdn.com/image/fetch/$s_!4FRI!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F558ad67a-bfca-469e-abd8-2edc7c8b888a_590x916.png, if you Google “cool websites”, r/slatestarcodex, who works at the intersection of computer science and Talmud, Jerusalem Area House Party, says it’s a myth, Adderall decreases all-cause mortality in ADHD, some crazy mosques, https://substackcdn.com/image/fetch/$s_!2W0c!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fc2be0549-aa2b-411d-b6a6-da50c34f7f86_1000x572.jpeg, Italy bans surrogacy, Italy’s tax code effectively bans startups?, Related, https://substackcdn.com/image/fetch/$s_!T3h-!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F08b011b3-ef20-42e5-91b2-33946b8ca7b6_1761x1355.jpeg, @cremieuxrecuel, responding to my critique of the cultural Christianity argument, My post, is finally going for, Trust Assembly, has an English-language Twitter account, has a new lab, wants to work on Alzheimers, and seems pretty based, not infinitely based, https://substackcdn.com/image/fetch/$s_!fY_K!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F6b3b61c8-6c48-4eb7-9608-426b738ab9c8_592x111.png, which can use your computer, Claim, Ems Dispatch, The first use of artificial insemination in humans, administers several personality tests to the same people, https://substackcdn.com/image/fetch/$s_!epEc!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F47c474c6-d68a-41e4-954e-d24cd00ec040_740x388.webp, Whither Tartaria, a well-researched article showing, in a new article he demolishes a different theory, When Hamilton Lost Its Snob Appeal, Why are people such jerks to public intellectuals?, more, Some prominent Substack psychiatrists doing a video Q&A, submit your questions here, Naomi Kanakia, No, Intelligence Is Not Like Height, Family-GWAS Reveals Effects Of Environment And Mating On Genetic Associations, Howe 2022, a more specific post where he responds to Gusev’s points one by one, argues that the usual method of attacking twin studies is obsolete, goes into more depth about one of those ways, The Guardian spied on them and nonconsensually revealed their existence, discussion, previously argued, the pioneering analysis of this technology, Gwern retracted his objections, says, polygenic selection, banned journalist Ken Klippenstein, you can read Klippenstein’s side here., appears to be unbanned now
paramecium1 mentions across 1 issues

paramecium is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between September 12, 2025 and September 12, 2025. The archive places it in contexts such as "a paramecium isn’t waxing nostalgic over its most recent birthday party". It most often appears alongside A Change of Heart, Abraham, Adams.

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paramecium
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1
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1
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September 12, 2025
Last seen
September 12, 2025
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Your Review: The Synaptic Plasticity and Memory Hypothesis
September 12, 2025 · Original source
Finally, forget about synaptic weight changes, and forget about synapses all together. Even single cells can learn and store memories! To me, this is the most persuasive argument against the necessity of synapses. Single-celled organisms, by definition, are just one cell, and hence have no nervous system or synapses to speak of. Yet it appears that they can learn and store (ethologically relevant) memories. The memories in question are certainly much simpler than what you might have in mind when you imagine human memory; a paramecium isn’t waxing nostalgic over its most recent birthday party. But one can argue that they are memories nonetheless.
Paramount Leader1 mentions across 1 issues

Paramount Leader is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between April 06, 2022 and April 06, 2022. The archive places it in contexts such as "including the Paramount Leader and their own successors"; "alternate who got the Paramount Leader position". It most often appears alongside America, American consulate, Attorney General.

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Paramount Leader
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1
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1
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April 06, 2022
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April 06, 2022
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Dictator Book Club: Xi Jinping
April 06, 2022 · Original source
Who chooses the members of the inner groups? In theory, the outer groups; for example, the Central Committee is supposed to elect the Politburo Standing Committee. In practice, these selections tend to be of the “2,970 in favor, 0 against” variety, so they must be taking marching orders from someone. Who? The Chinese government doesn’t talk about it much, but probably the members of the Politburo Standing Committee hand-pick everyone, including the Paramount Leader and their own successors.
When Xi Jinping first joined the Politburo Standing Committee in 2008, eight of its nine members were engineers. Paramount Leader Hu Jintao was a hydroelectric engineer. His second-in-command Wen Jiabao was a geological engineer. There were two electrical engineers, a petroleum engineer, a radio engineer, and two chemical engineers (including Xi himself). The only non-engineer was Li Keqiang, an economist.
When Jiang reached his term limit, he stepped down in favor of Hu Jintao, former secretary of the Communist Youth League. The CYLers formed a power bloc distinct from the Shanghai Gang, drawing more on inland rural commoners. The two blocs may have made some kind of power-sharing agreement behind closed doors, probably involving a pledge to alternate who got the Paramount Leader position
paranormal1 mentions across 1 issues

paranormal is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between July 14, 2023 and July 14, 2023. The archive places it in contexts such as ""getting really into cryptids and paranormal nonsense."". It most often appears alongside !Kung San, aboriginal people on the west coast of Canada, Adam Smith.

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paranormal
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1
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1
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July 14, 2023
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July 14, 2023
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Your Book Review: The Educated Mind
July 14, 2023 · Original source
Reviewer: I won’t share too many personal details; I am wearing a mask, after all. But as a kid, a lot of my learning was driven by jokes — I read Calvin and Hobbes so many times, I probably had all the SAT words memorized. I got a feel for the constraints of reality through the copy of Guinness Book of World Records that my mom got for me when I was nine years old — right at the beginning of Egan’s “Romantic” span. And I probed what might lie beyond the edges of reality by getting really into cryptids and paranormal nonsense.
parapsychologist1 mentions across 1 issues

parapsychologist is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between November 28, 2021 and November 28, 2021. The archive places it in contexts such as "some parapsychologist has done twenty studies, all of which prove psychic phenomena exist". It most often appears alongside Abba Eban, ACX, Albert Einstein.

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parapsychologist
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1
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1
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November 28, 2021
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November 28, 2021
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Open Thread 200
November 28, 2021 · Original source
But as I’ve tried to point out elsewhere, adding more studies can only address problems within your model, not problems outside your model. Suppose that some parapsychologist has done twenty studies, all of which prove psychic phenomena exist (and there are many such parapsychologists!) Does it help if she works for another year or two, and we get forty such studies? How about another decade, and we get two hundred such studies? Who cares?! We already know that this parapsychologist, using whatever methodology she uses, is able to consistently get positive results. It’s not like all twenty of her studies went badly just by coincidence! So either you should believe in psychic phenomena, or you should believe that this genre of study is bad (ie an outside-of-model problem) and we need some independent researcher or some better methodology to try replicating it.
Paris Agreement1 mentions across 1 issues

Paris Agreement is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between February 01, 2021 and February 01, 2021. The archive places it in contexts such as "How much will global temperatures increase if we (do/don't) rejoin the Paris Agreement?". It most often appears alongside 2021, Alex Azar, Anthony Fauci.

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Paris Agreement
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1
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1
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February 01, 2021
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February 01, 2021
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Metaculus Monday
February 01, 2021 · Original source
You don't have to believe them if you don't want to. But this is a pretty impressive example of decentralized expertise weighing in on important inputs to a policy question. Should we hold human challenge trials or not? Well, if we don't, an extra 50,000 people or so will die. You can do this with any question. How much will global temperatures increase if we (do/don't) rejoin the Paris Agreement? How much will British GDP be in 2025 if there (is/isn't) Brexit? How many people will get shot by cops next year if we (do/don't) go ahead with some defund-the-police plan?
PARIS IN THE THE SPRINGTIME test1 mentions across 1 issues

PARIS IN THE THE SPRINGTIME test is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between June 10, 2025 and June 10, 2025. The archive places it in contexts such as "they might fail the infamous PARIS IN THE THE SPRINGTIME test". It most often appears alongside brain, Chalmers, conscious.

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1
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1
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June 10, 2025
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June 10, 2025
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P-Zombies Would Report Qualia
June 10, 2025 · Original source
...o), and an outside observer might notice that they report on some levels of mental processing, but not others (like humans do). For example, they might fail the infamous PARIS IN THE THE SPRINGTIME test, reporting only one THE rather than two. The observer would conjecture that the p-zombies’ speech is produced by a part with access to high-level processing (after the P...
...to each other (like humans do), and an outside observer might notice that they report on some levels of mental processing, but not others (like humans do). For example, they might fail the infamous PARIS IN THE THE SPRINGTIME test, reporting only one THE rather than two. The observer would conjecture that the p-zombies’ speech is produced by a part with access to high-level processing (after the P...
Paris Peace Pact1 mentions across 1 issues

Paris Peace Pact is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between July 01, 2022 and July 01, 2022. The archive places it in contexts such as "No-War Pact,” as the Paris Peace Pact was known in Japan". It most often appears alongside 1793, 1821, 1847.

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Paris Peace Pact
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1
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1
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July 01, 2022
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July 01, 2022
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Your Book Review: The Internationalists
July 01, 2022 · Original source
The US keeps starting or engaging in wars, like in Libya, Afghanistan, and Iraq. I will briefly summarize the 3 major sections of the book and how they tackle the first five claims. Section 1: The Old World Order This section refutes the claim that outlawry of war wasn't actually a significant change for anyone at the time. To do so, it covers the history of the international laws of war as described by Hugo Grotius in a set of books titled The Law of War and Peace, including how he came to write it, what the laws were, and how they were used and understood. In this section, H&S work to fully immerse us in the laws of war before the Peace Pact, and the ways that people understood war as a result. I’ve already included a number of things about this up above, so I’ll just put in a few interesting notes here, and if you want more persuasion that people viewed war differently, I’d suggest you pick up the book. There is lots of historical evidence that attitudes toward war before the Peace Pact were not like attitudes toward war today, that people - lawyers, diplomats, sovereigns, and citizens - believed it to be normal and legal, and frequently justified. Conquest in response to debts or offenses was one of the primary motivators of war in the period ruled by the Old World Order (generally, from some time before 1625 when Grotius wrote the rules down to 1928, when the Peace Pact was signed), though H&S also document some of the weirder ones, like a King who declared that they had the right to wage war against another because the other King stole his wife. But because Grotius had declared that no one outside the belligerents could determine whose side was just without violating neutrality, the reasons for war were largely whatever Monarchs could get away, which ran the gamut. Perhaps because it was fashionable, perhaps to convince their citizenry of their rightness, Monarchs paid handsomely for famous thinkers to write manifestos explaining why they were going to war, and other Monarchs and the citizenry generally accepted these reasons. It would be like if Putin had called up Google co-founder Sergey Brin and asked him to write out why Russia had the right to conquer Ukraine, and then everyone else shrugged and decided, sure, that sounds reasonable. Heads of state enlisted esteemed writers and scholars as well as experienced lawyers to draft [war manifestos]. The English military and political leader Oliver Cromwell commissioned John Milton, the great epic poet, to write A Manifesto of the Lord Protector of the Commonwealth in 1655 when he ordered the invasion of the Spanish possessions in the Caribbean. In 1703, the Holy Roman Emperor Leopold I employed Gottfried Leibniz, the rationalist philosopher, co-inventor of calculus, and a trained lawyer, to compose the Manifesto for the Defense of the Rights of Charles III, which defended the empire’s involvement in the War of the Spanish Succession. Commodore Perry arrived in Japan in 1853 and returned for real the next year. Because they were so confused about how the laws of war were supposed to work, Japan proceeded to send Nishi Amane to the Netherlands to study the Law of War and Peace, and twenty years later, in 1875, Japan conquered Korea. Their logic for doing so was that they were afraid Europe or China would get there first. The world recognized their conquest at the time, though after WWII they were made to give it up. Korea was alluring prey for aggressive Western nations. As Nishi Amane [the scholar who brought the Grotian rules to Japan] would later explain, defending one’s borders “is like riding in a third-class train; at first there is adequate space but as more passengers enter there is no place for them to sit. The logic of necessity requires the people to plant both feet firmly and expand their elbows into any opening that may occur for, unless this is done, others will close the opening. (Chapter 6) Section 2: The Transformation Period Recall our list of counterclaims, #s 2 and 3. 2. Outlawry wasn't taken seriously at the time by the signatories - that it was just feel-good propaganda. 3. World War II proves that it failed, so it wasn't important. This section tells the story of how the Peace Pact came into existence, including how influential it was on the thinkers of the time. Throughout the 1930s and 40s, thinkers and diplomats attempted to turn the Peace Pact into practice, and then, when World War II demonstrated that they needed significantly more teeth to make the Peace Pact real, created the United Nations and other international institutions dedicated to supporting the Pact’s goals. At the time, they viewed World War II as a sign that they hadn’t gotten the right combination of institutions to make the Peace Pact succeed, not that it wasn’t important. This was a classic situation of needing More Dakka and they did, indeed, keep adding more until it worked. In an account composed more than a decade later, Jackson recounted that this view of the Pact was shared by the president and his inner circle. The Peace Pact, he reported, “left no vestige of legal right for [a state] to resort to a war of aggression. From the beginning, Roosevelt, Hull, Welles, Stimson and I had been in agreement that Hitler’s war . . . was an illegal one, and that other powers were under no obligation to remain indifferent. (Chapter 11) There is some counter-evidence in support of #2, from the side of the Japanese at least. Japan, for example, did not think that it had renounced the rules of the Old World Order on August 27, 1928. Its signing of the “No-War Pact,” as the Paris Peace Pact was known in Japan, was regarded as a diplomatic gesture, a noble proclamation affirming the aspiration of all civilized nations to seek peace. Indeed, Japanese officials considered it a sign of how far their nation had come that it was included among the fifteen countries at the grand ceremony in Paris. (Chapter 7) But at least on the Allies side, they had intended it seriously, and as World War II went on, that intention redoubled. Sumner Welles, Undersecretary of State during World War II, was assigned by Roosevelt to create a plan for peace after the war. What he and James Shotwell authored was effectively an outline of the United Nations, and they put the Peace Pact at the very center of it. Shotwell was far from subtle about his effort to treat the Pact as a starting point. He placed the Pact at the start of his preliminary draft. Article 1 repeated the Pact verbatim. Article 2 provided that “[t]he United Nations, in order to strengthen and safeguard the peace of nations as set forth in the General Pact for the Renunciation of war, agree to cooperate in the establishment of the necessary instrumentalities for its effective maintenance.” What followed was an outline of nearly every essential institutional component of the modern-day United Nations. Ten days later he circulated a more detailed draft, now entitled “Provisional Outline of International Organization.” (Chapter 8) It wasn't just the United Nations. NATO was built off of the Atlantic Charter, and it was also designed to reinforce the Peace Pact. This is why it's reasonably accurate to describe it as a defensive alliance. The [first draft of the Atlantic Charter] was a remarkable document. It began by restating the principles of the Stimson Doctrine—there would be no conquest; the two countries would “seek no aggrandizement, territorial or other.” Moreover, there would be “no territorial changes that do not accord with the freely expressed wishes of the peoples concerned.” The Charter looked ahead to a time “after the final destruction of the Nazi tyranny”—a remarkable statement for a neutral in the war—and declared the two states’ “hope to see established a peace which will afford to all nations the means of dwelling in safety within their own boundaries. (Chapter 8) This section brings to bear quotes from leaders at the time showing how important they considered the outlawry of war, how they viewed it as changing the world, but also how unprepared they were for how to react to countries choosing to ignore the Pact. Most importantly, they show how the Allies were strongly motivated to fight World War II specifically to preserve and expand the Pact, to make the world safe for peace. Unfortunately, then, as now, Russia/the Soviet Union did not quite live up to the ideals that the Allies generally advocated for. The Soviet Union took territory after World War II, the only one of the Allies to do so. The only ally to gain any significant territory after the war was the Soviet Union. More than twenty million of the nation’s citizens had died in the course of the war, and Stalin insisted on several territorial gains as the price of peace—many, but not all, of them in areas previously contested. … These concessions to Stalin were seen by the other Allied powers as regrettable deviations from accepted law, not precedents to be followed in the future. (Chapter 13) To be fair, we are talking about Josef Stalin, here. Who’s surprised? Section 3: The New World Order Recall our list of counterclaims, #s 4 and 5. 4. The world isn't more peaceful post outlawry. 5. Any increase in peace since World War II is due to democracies, nuclear weapons, or other reasons, and not the Peace Pact. H&S walk through the best academic evidence we have of whether the world is more peaceful today than it was in the period from 1816 (when our data collection starts being decent) to the Peace Pact. They then spend some time discussing why the evidence better supports the Peace Pact than other causes. In particular, H&S highlight that only since the Peace Pact have countries been denied territorial gains from their conquests. There's a lot of detail in there. Here's just a taste of it. A loose team of political scientists has assembled comprehensive data to help them study war. The resulting project, with the intentionally clinical name “Correlates of War,” hosts datasets on everything from “militarized interstate disputes” to “world religion data” to “bilateral trade.” Most relevant here, it includes extensive data on “territorial change”—a record of every single territorial exchange between states from 1816 to 2014, totaling over eight hundred entries. What do our 254 cases of territorial change tell us? They tell us something that is at once striking and surprising: Conquest, once common, has nearly disappeared. Even more unexpected, the switch point is that now familiar year when the world came together to outlaw war, 1928. From the time the data start in 1816 until the Peace Pact opened for signature in 1928, there was, on average, approximately one conquest every ten months (1.21 conquests per year). Put another way, the average state during this period had a 1.33 percent chance of being the victim of conquest in any given year. Those may seem like pretty good odds. They are not: A state with a 1.33 percent annual chance of conquest can expect to lose territory in a conquest once in an ordinary human lifetime. After 1948, the chance an average state would suffer a conquest fell from once in a lifetime to once or twice a millennium. (Chapter 13) The US wars in Afghanistan, Iraq, and Libya One disappointment I have is that H&S do not spend much time discussing the US wars of the last two decades. The book was published in 2017, so there’s really no excuse for this. Even counting them, their claim that wars since the Peace Pact have been fewer and less world-changing than before the Peace Pact still holds up, but since they don’t directly discuss the most notable wars of the last two decades, they leave a significant hole in their argument. I can imagine defenses that they would make, but they should have made them. They mostly refer to these conflicts either as not a conquest (since the US isn’t officially running those places now) or as a side effect of the Peace Pact in allowing failed states (See Addendum 1 for more on that) More recently, the United States invaded Iraq in 2003, toppled Sadaam Hussein, and installed the Coalition Provisional Authority to govern the country. But what’s most notable about these “nonconquests” is how ineffective and unstable they usually are. Exerting influence indirectly is inefficient and expensive. (Chapter 13) And in 2015 alone, high-fatality civil wars continued in Nigeria, South Sudan, Yemen, Syria, Iraq, Afghanistan, Pakistan, Somalia, and Ukraine. Why, if war has been outlawed, is there still so much conflict? The answer is that these conflicts are not prohibited by the Pact. Indeed, they are the predictable consequences of it … the prohibition on the use of force by one state against the territory of another has allowed two sources of conflict to simmer… within [states]. (Chapter 15) The broader intellectual history of war Reading The Internationalists led me to want to read a broader intellectual history of war. H&S include some comments that hint at it, for example describing the Principle of Distinction and other agreements made about how to behave during war. Fortunately for the civilians of Europe, the biblical model of war was finally repudiated. By the middle of the eighteenth century, European armies had come to recognize a “Principle of Distinction,” the doctrine central to modern humanitarian law, which distinguishes between soldiers and civilians and protects the latter from the former. The Principle of Distinction was the first curtailment of Grotius’s blanket immunity for those waging war. In the next century, it was followed by a flood of new legal regulations placing stricter controls on a soldier’s license to kill. International treaties protected the wounded and medical personnel (First Geneva Convention, 1864) prohibited the use of fragmenting, explosive, and incendiary small arms ammunition (St. Petersburg Declaration, 1874) banned explosives from balloons, asphyxiating gas, and dum-dum bullets (First Hague Convention, 1899) and proscribed pillage, the execution of surrendering soldiers and prisoners of war, and forcing civilians to swear an allegiance to a foreign power (Second Hague Convention, 1907). (Chapter 3) But the history of this and other pre-Peace Pact intellectual history of war is thin within the text, as the point H&S are chasing is specific to the Peace Pact's relevance in history, not the broader history of war. Some of my favorite books are books that tie together aspects of history across wide gulfs, which The Internationalists succeeds at. It’s rare and delightful to see how a piratical ship capture by the Dutch in the 16th century ties together with the opening of Japan, the US battles with Mexico, and finally, the creation of the United Nations. H&S’s perspective is that the Peace Pact marks a turning point, and one that should not be forgotten. It’s also clear that it marks a capstone on a long history of small changes that are also, themselves, interesting battles in the long-running war to make the world less intolerable. In the end, they identify four key changes in the intellectual landscape, with Lauterpacht’s fingers in nearly all of them. Neutrality no longer requires impartiality. States can help those they view as victims.
Inline links: More Dakka
Parisian kitchen1 mentions across 1 issues

Parisian kitchen is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between June 10, 2021 and June 10, 2021. The archive places it in contexts such as "I’ll take the Parisian kitchen over that any day". It most often appears alongside 1984, American, American ‘hobo’ culture.

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Parisian kitchen
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1
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1
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June 10, 2021
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June 10, 2021
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Your Book Review: Down And Out In Paris And London
June 10, 2021 · Original source
I’ll take the Parisian kitchen over that any day. His description of the old man’s cough, in particular, makes me never want to sleep in a room with another person ever again. And Orwell seems to share this notion, because he quickly starts to drift from house to house, even “sleeping” in the outdoors sometimes, though in those cases sleep is actually impossible due to harassment by police. Instead he and the other tramps are forced to sit on benches, nodding in an out of consciousness, never really resting. It’s this that sends them into the horrible flophouses. Orwell points out that three or four hours of bad sleep is still a significant improvement over a night apent out on the street.
Parkinson's1 mentions across 1 issues

Parkinson's is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between August 13, 2024 and August 13, 2024. The archive places it in contexts such as "they’re also effective against stroke, heart disease, kidney disease , Parkinson’s , Alzheimer’s , alcoholism , and drug addiction". It most often appears alongside alcoholism, Alhadeff et al. (2012), alpha-adrenergic receptors.

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Parkinson's
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1
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1
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August 13, 2024
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August 13, 2024
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Why Does Ozempic Cure All Diseases?
August 13, 2024 · Original source
...n. But only a small one. GLP-1 receptor agonist medications like Ozempic are already FDA-approved to treat diabetes and obesity. But an increasing body of research finds they’re also effective against stroke, heart disease, kidney disease , Parkinson’s , Alzheimer’s , alcoholism , and drug addiction . There’s a pattern in fake scammy alternative medicine. People get excited about some new herb. They invent a laundry list of effects: it improves heart health, softens...
Parkinson’s1 mentions across 1 issues

Parkinson’s is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between March 09, 2026 and March 09, 2026. The archive places it in contexts such as "including an influential study linking Parkinson’s to the gut". It most often appears alongside Anthropic, Astralcodexten Com, Demis Hassabis.

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Parkinson’s
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1
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1
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March 09, 2026
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March 09, 2026
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Open Thread 424
March 09, 2026 · Original source
3: ACX grantee Markus Englund announces a first set of results from his project to automate anomaly detection in scientific data, finding serious and reportable data issues in eighteen papers, including an influential study linking Parkinson’s to the gut. He plans to scale up his efforts by over an order of magnitude in the year ahead.
Inline links: announces a first set of results
Parkinson’s Disease1 mentions across 1 issues

Parkinson’s Disease is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between August 13, 2024 and August 13, 2024. The archive places it in contexts such as "GLP-1 Receptor Agonists: A New Treatment in Parkinson’s Disease gives us this diagram". It most often appears alongside alcoholism, Alhadeff et al. (2012), alpha-adrenergic receptors.

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Parkinson’s Disease
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1
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1
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August 13, 2024
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August 13, 2024
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Why Does Ozempic Cure All Diseases?
August 13, 2024 · Original source
GLP-1 Receptor Agonists: A New Treatment in Parkinson’s Disease gives us this diagram:
Inline links: GLP-1 Receptor Agonists: A New Treatment in Parkinson’s Disease
parliament1 mentions across 1 issues

parliament is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between August 11, 2023 and August 11, 2023. The archive places it in contexts such as "Yeltsin first illegally dissolved the parliament". It most often appears alongside 1993 Russian constitutional crisis, 2011 parliamentary election, 2011-2014 protests.

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parliament
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1
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1
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August 11, 2023
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August 11, 2023
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Highlights From The Comments On Putin
August 11, 2023 · Original source
Interestingly, Short begins his biography by explaining why he doesn't think the apartment bombings were Putin's doing. Among other things, there was a smaller bomb in Volgodonsk set off by gangsters a few days before the apartment bomb which had appeared in Moscow press in a manner that could fool a parliamentarian into thinking another apartment bombing had occurred. Also, for some stupid reason, it really was KGB/FSB practice to conduct drills like the Ryazan incident. Finally, the bombings occurred in the context of a Russian counteroffensive in Dagestan, and the conspiracy version requires us to believe that insurgents like Shamir Basayev were willing to lie about the origin of the bomb to help Putin for some reason.
For the culture wars: I think Putin uses it as a tool. Majority of Russians hardly believe in God, but find some kind of church desecration (and what Pussy Riot did would qualify in people's mind) to be disgusting. Thus, Pussy Riot action put the anti-Putin coalition in a kind of trap: on the one hand, their persecution was absolutely lawless (the corresponding penal code article is extremely broad in formulation, but is normally used to persecute people who aggresively brandish their weapons but don't attack anyone), but on the other hand, the majority of Russian citizens were not happy with the Pussy Riot actions. This allowed Putin to rebrand himself as a savior of the "traditional values" (whatever they are) and claim that the anti-Putin coalition wants to destroy them, getting over the general weariness of Russians with the ruling party (which could be noted from the 2011 parliamentary election: many of the regions where United Russia had bad performance do not have big cities in them).
Why this couldn't happen in US? The key reason, in my opinion, is not because CIA and FBI wield less power than FSB, but because the Russian Constitution of 1993 gives exceeding powers to the president even in its original form. By itself, it was a result of the constitutional crisis of 1993 (https://en.wikipedia.org/wiki/1993_Russian_constitutional_crisis), where Yeltsin first illegally dissolved the parliament, then ignored the decision of the constitutional court and his impeachment by the parliament to bomb the parliament into submission and later dissolution. I'd say that this coup was the key blow to the Russian democracy, all that happened afterwards inside Russia were just consequences (which obviously does not absolve the people who brought the consequences into life).
Inline links: https://en.wikipedia.org/wiki/1993_Russian_constitutional_crisis
Parsis1 mentions across 1 issues

Parsis is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between January 18, 2024 and January 18, 2024. The archive places it in contexts such as "survey of highly-successful groups, from Parsis to Copts to Jews". It most often appears alongside @april, @somefoundersalt, ACX.

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Parsis
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1
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1
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January 18, 2024
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January 18, 2024
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Links For January 2024
January 18, 2024 · Original source
30: Cremieux: How Do Elite Groups Form? Good overview of Greg Clark style persistence literature and survey of highly-successful groups, from Parsis to Copts to Jews. Interesting new theory of Jewish achievement based on 1st century BC decree that all Jews have to be literate.
Inline links: How Do Elite Groups Form?
PARTI1 mentions across 1 issues

PARTI is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between August 14, 2022 and August 14, 2022. The archive places it in contexts such as "testing some prompts on one of the bigger post-DALLE2 image models (PARTI? Imagen?)". It most often appears alongside Asterisk, asteriskmag.com, Astralcodexten Com.

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PARTI
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1
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1
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August 14, 2022
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August 14, 2022
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Open Thread 237
August 14, 2022 · Original source
2: I’m still interested in testing some prompts on one of the bigger post-DALLE2 image models (PARTI? Imagen?) in order to resolve a bet. Please get in touch with me (scott@slatestarcodex.com) if you can help.
partial glossectomy1 mentions across 1 issues

partial glossectomy is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between May 10, 2024 and May 10, 2024. The archive places it in contexts such as "I got a partial glossectomy in Oct. 2022". It most often appears alongside "Most Drugs Are Bad For You", 1123581321, California.

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partial glossectomy
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1
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1
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May 10, 2024
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May 10, 2024
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Highlights From The Comments On Hanson And Health Care
May 10, 2024 · Original source
Take the HNSCC that's killing me: I got a partial glossectomy in Oct. 2022. Mine had some high-risk features, but I was assured that, with radiation therapy, it wouldn't recur In retrospect, I obviously should've done chemo and radiation, but at the time I was pleased to not need chemo, and I foolishly didn't look deeply into the data on recurrence, which is common for HNSCC, and I didn't seek second opinions.
Participant aggregate1 mentions across 1 issues

Participant aggregate is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between March 05, 2024 and March 05, 2024. The archive places it in contexts such as "Participant aggregate: This is the “wisdom of crowds” one". It most often appears alongside @wc1766, Adam, Adam Unikowsky.

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Participant aggregate
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1
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1
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March 05, 2024
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March 05, 2024
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Who Predicted 2023?
March 05, 2024 · Original source
Participant aggregate: This is the “wisdom of crowds” one. If you average the guess of every participant (eg if someone says 80% chance Biden leads, and another says 90% chance, then you go with 85%), you usually do better than the vast majority of individuals. In this case, the aggregate was 95th percentile, beating out superforecasters and Manifold.
particle physics1 mentions across 1 issues

particle physics is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between July 13, 2022 and July 13, 2022. The archive places it in contexts such as "set theory, and particle physics". It most often appears alongside 1890s, Alan Turing, Albert Einstein.

Reference entry
particle physics
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1
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1
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July 13, 2022
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July 13, 2022
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Book Review: The Man From The Future
July 13, 2022 · Original source
John von Neumann invented the digital computer. The fields of game theory and cellular automata. Important pieces of modern economics, set theory, and particle physics. A substantial part of the technology behind the atom and hydrogen bombs. Several whole fields of mathematics I hadn’t previously heard of, like “operator algebras”, “continuous geometry”, and “ergodic theory”.
Partner Charity Application Form1 mentions across 1 issues

Partner Charity Application Form is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between July 24, 2025 and July 24, 2025. The archive places it in contexts such as "please fill out the Partner Charity Application Form". It most often appears alongside ACX, ACX Grant, ACX Grants.

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1
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1
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July 24, 2025
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July 24, 2025
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Apply For An ACX Grant (2025)
July 24, 2025 · Original source
Some of our applicants are good projects, but not a good match for us, and we want to shop them around to other philanthropists and charities who might have different strengths or be able to work with larger amounts of money. If that’s you, please fill out the Partner Charity Application Form
Inline links: Partner Charity Application Form
Pascal Mugging1 mentions across 1 issues

Pascal Mugging is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between February 10, 2022 and February 10, 2022. The archive places it in contexts such as "expected value calculation still ends up with a happy face /pascal-mugging"; "or you only believe in it 10%, but know that the expected value calculation still ends up with a happy face /pascal-mugging". It most often appears alongside 2018, @BendiniUK, @benyeohben.

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Pascal Mugging
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1
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1
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February 10, 2022
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February 10, 2022
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ACX Grants ++: The Second Half
February 10, 2022 · Original source
#113: Increase Own Intelligence, Then Write About How My name is David Gretzschel and I want money to increase my own intelligence full-time for about a year. Once I have succeeded (more than I already have), I will teach others how to do this. The benefits of this are obvious. And I already know how to do that for the most part. I have a concrete foundation in the form of a synesthetic encoding scheme, that I can build on. I merely need the time to do an intense amount of training without being distracted by either having a job or not having one and starving. And practice how to use them on various mathematical and computational problems. And a bunch of other things. Details are in the long pitch (see below). So I need 20.000 dollars to not worry about rent and food for that time. Please send them in Bitcoin here: 3Qcm3UJRuFca1fTkf2iPPEkU3PevpzPuwP I certainly would have use for more money, too. (though it'd not be necessary, I don't want to dissuade you from it, if that's an option) So do feel free to shower me with the stuff, if you have it and believe in my cause. (or you only believe in it 10%, but know that the expected value calculation still ends up with a happy face /pascal-mugging) With 10.000 dollars I'd still commit to a year, though that would be a bit tighter than I’d like. The longer pitch is here: https://docs.google.com/document/d/170WETB6enUOzQEzwbwmOCVHz9VkBe4R86rCh_ewvOcg/edit?usp=sharing . If you have further questions/conditions/need more persuasion, send an email to: davidgretzschel@gmail.com
Pascalian reasoning1 mentions across 1 issues

Pascalian reasoning is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between December 12, 2023 and December 12, 2023. The archive places it in contexts such as "It’s . . . what’s the English term . . . Pascalian reasoning". It most often appears alongside 2024, Aaron Peskin, accelerationist conspiracy.

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Pascalian reasoning
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December 12, 2023
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December 12, 2023
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Son Of Bride Of Bay Area House Party
December 12, 2023 · Original source
“Don’t get me wrong, I think soldiers are great. I just see a lot of bright promising young people whose mental health goes down the drain when they start believing in Russians. They have panic attacks about ‘what if the Russians bomb my city?’ and feel this crushing guilt that they need to ‘get their parents away from the front line’ or ‘rescue family members’, or else they’re bad people. I think this is kind of a - what’s the English word - cult. If you believe there are Russians ready to overrun your country, you can justify any atrocity. Why not institute slavery, so you can force people to join the war? Why not kill everyone in Russia, so they can’t threaten you again? Why not commit terrorism against Russian targets? Why not give me all your money, so I can stop these evil, evil Russians? It’s . . . what’s the English term . . . Pascalian reasoning. You know, in the past the doomsayers talked about “overpopulation” and “global cooling”. Now they talk about ‘Russians’ and ‘Putin’. I think you should just live a normal and virtuous life, be honest, be kind to your neighbors.”
Passover1 mentions across 1 issues

Passover is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between May 04, 2021 and May 04, 2021. The archive places it in contexts such as "I read the book close enough to Passover". It most often appears alongside 2008, 9/11 attacks, A Brief History Of Neoliberalism.

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Passover
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1
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May 04, 2021
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May 04, 2021
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Book Review: A Brief History Of Neoliberalism
May 04, 2021 · Original source
Reading A Brief History Of Neoliberalism, I got the impression that our economic amnesia about the 1970s is no less striking. There was no 1929-style thunderclap market crash, just one damn thing after another. I read the book close enough to Passover that the Ten Plagues came to mind. The dollar glut (*spills drop of wine*). The Nixon Shock (*spills another drop*). The Economic Stabilization Act of 1970. The fall of the gold standard. The 1970s Steel Crisis. The 1973 Oil Crisis. Stagflation. The Winter of Discontent. The 1979 Energy Crisis. And the Angel of Death was the Volcker Shock of 1980, when unemployment crossed 10% and people mailed the Federal Reserve coffins and unused two-by-fours in protest.
Inline links: dollar glut, Nixon Shock, The Economic Stabilization Act of 1970, fall of the gold standard, 1970s Steel Crisis, 1973 Oil Crisis, Stagflation, Winter of Discontent, 1979 Energy Crisis, Volcker Shock of 1980
Patel Motel Cartel1 mentions across 1 issues

Patel Motel Cartel is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between May 07, 2024 and May 07, 2024. The archive places it in contexts such as "Indian castes are overrepresented in certain industries (eg the Patel Motel Cartel)". It most often appears alongside affirmative action, Africa, African National Congress.

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Patel Motel Cartel
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1
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1
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May 07, 2024
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May 07, 2024
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Highlights From The Comments On "The Origin Of Woke"
May 07, 2024 · Original source
I agree there’s something to this - I’ve seen it used, for example, to explain why certain Indian castes are overrepresented in certain industries (eg the Patel Motel Cartel), Jews in other industries, etc.
Inline links: Patel Motel Cartel
PATERNALISM1 mentions across 1 issues

PATERNALISM is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between July 18, 2024 and July 18, 2024. The archive places it in contexts such as "What works elsewhere is PATERNALISM". It most often appears alongside Access Pass, Africa, America.

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PATERNALISM
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1
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1
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July 18, 2024
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July 18, 2024
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Highlights From The Comments On Mentally Ill Homeless People
July 18, 2024 · Original source
$1 billion/year in projected costs, translated into Californian, means $100 trillion quadrillion/year in actual costs. Of these, I think 3 is the biggest deal. If it’s as hard to commit someone to these institutions as it is to convict them of a crime, then these institutions don’t help much above how much the existence of prison also helps (eg not much). If you invent a new legal maneuver where it’s easier to commit someone than to convict them of a crime, then why do you even need the step where you build the institution? Just invent the legal maneuver and send more people to prison! I think that maybe the thought is that the institution seems more “humane” than prison, and so people will be more willing to allow low-friction legal maneuvers for confining people there. I think this is cope; not only won’t the institutions be more humane than prisons, but people won’t believe they are and won’t allow the low-friction legal maneuvers. Drethelin writes: What if we abolish the DEA and just let anyone buy anti-psychotics over the counter? This would be the FDA we’re abolishing, but otherwise yes, this is the sort of clever outside-the-box thinking that I appreciate from my commenters. Antipsychotics are very cheap (some well-regarded drugs like Abilify and Seroquel cost about ~$10 per month of pills). On the other hand, homeless people have very little money. So if you were going to do this, it would make sense for the government to give them away for free. These drugs have many potentially serious side effects. But it’s not clear how much homeless people’s 5-minute monthly visits with a bored Medicaid doctor does to avert these side effects, over having some kind of pharmacist or advocate or social worker in the free distribution center giving helpful advice. Like everything, I think this would only help around the edges - the fraction of homeless mentally ill people who drugs can help, who are willing to take the drugs, and who are prevented only by cost and bureaucracy. What percent is that? Low confidence guess 25%. DZ writes: I think you’re missing the goal of a short arrest (few days). Part of the problem is the homeless are in areas where society doesn’t want them to be. They’re near city downtowns where tourists spend time or near commercial districts or in otherwise nice parks. If you can arrest them for a few days and keep arresting them until they move somewhere else … the goal is to eventually force them to move to the more acceptable areas vs. least acceptable areas. This is obviously not ideal but in the mean time the city gets more tourism, more office rentals, etc. Europeans ruthlessly arrest homeless people who hang out in the touristy areas. SF doesn’t, yet. I commented that I was worried that “out of touristy areas” means “into residential areas”. And I feel worse making residents deal with this than tourists, and am less confident that the city cares enough about them to fight back. DZ responded: Agreed. People don’t want them in the residential areas or suburbs either and for good reason. But my guess is cities can identify certain areas where they would prefer the tents to set up. Something like industrial areas or run down parks. The key is that city officials should be able to use arrests as a strategy to move the tents/homeless concentrations without having to face a million lawsuits. I don’t know if there are really areas like this, but I welcome learning more from people who know cities better. SMK writes: This probably sounds draconian and cruel, too, but in fairness, all these discussions seem to assume that this person is in San Francisco and can never ever leave for some other, more affordable place. I get it -- it's tough leaving home, and maybe they'd be leaving friends. But they wouldn't be the only people leaving SF over rent prices, and they'd pretty clearly be among the most rational. So I dislike articles like this when they say things like "the average wait time for a homeless shelter bed is 826 days" or "cheap apartments in SF are $1000 / month." I have a friend who was homeless for around a year in another major American city, and he said it was always 100% feasible to get a shelter bed if he wanted one. Indeed, there were several options. On a different note, I also think that if one were going to go a "cruel and draconian" route, homeless shelters might be able to change policies to better support that and prevent some of the issues you highlight. If it takes 826 days to get a shelter bed, then zero of the typical people you mention who are briefly homeless are getting shelter beds. If all of the people who were homeless for longer were either leaving or in jail, then more of those people probably would get beds. Am I saying this is the policy I favor? No, I agree it's a hard problem and I'm not sure what the right answer is. But things like this need to be kept in mind, too. Again, I think it’s helpful to go to the specific policy level. What’s the policy here? Give homeless people brochures reminding them that other cities exist? I’m sure they know this. Give homeless cities free mandatory bus trips to those other cities? What prevents the other cities from giving them free mandatory bus trips back? Even if they don’t, what if the homeless prefer being homeless in San Francisco to having a better situation in a cheaper city? A bus from Phoenix to SF is only $60; even a homeless beggar might be able to scrounge up that much money if they’re motivated. Maybe some plan like making a deal with a big cheap city in Texas to take SF homeless in exchange for money, and as soon as the homeless get off the bus, they’re met by a Texan social worker who gives them a shelter bed and social services? Might help along the edges, but remember that only about half of homeless people want/will accept shelter beds (depending on how good the shelter beds are). Sergei writes: After checking a bit, let me point out the obvious. What works elsewhere is PATERNALISM. Once you are in the "clutches of psychiatry", they don't let you go. Upon release you are placed into some sort of housing, your appointments are monitored and a social worker will find you and drive you there. You will be given multiple chances to get a job and/or rehab. Your meds will be delivered to you if you cannot pick them up. They remind you to take them. There will be a social safety net so you are never in a situation where you end up on the street unless you really really try to. In retrospect, it makes sense: people who are not able to take care of themselves for a time because of a fixable mental infirmity are taken care of by the state, until they can. That's what we do with children already. I continue to want people to provide details. “They don't let you go" - okay, so the person is in a locked facility? Placed in "some kind of housing"? Does the housing have locks on the door, or can they leave? What if they do leave? "Multiple chances to get a job", oh, great, with whom? How are you enforcing that they take mentally ill people? What happens when the mentally ill people are less good workers than other people they could hire, or have some kind of crisis on the job, as even the best-treated person might once in a while? Maybe we can charitably fill in the details. Something like: Ban some combination of camping outside and being visibly mentally ill.
Inline links: writes
Path of Exile1 mentions across 1 issues

Path of Exile is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between January 17, 2025 and January 17, 2025. The archive places it in contexts such as "A veteran Path of Exile gamer presents evidence". It most often appears alongside @tamaybes, @venturetwins, A16Z.

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Path of Exile
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1
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January 17, 2025
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January 17, 2025
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Links For January 2025
January 17, 2025 · Original source
I agree with this solution. 3: Ruxandra Teslo and Willy Chertman: The Case For Clinical Trial Abundance 4: This month in nominative determinism: NYT article calculating your chance of winning the lottery, by Victor Mather (h/t Yafah Edelman). 5: Someone is working on a dating site that uses your conversations with Claude to find a match. Link here, although so far it’s just a landing page where you can register interest (h/t @venturetwins) 6: The Lyttle Lytton Contest searches for the worst possible opening line for a novel; it’s been going on since 2001 and this year’s results are in. 7: Gary Marcus and Miles Brundage have made a bet about AI progress. I agree with @tamaybes and others in saying that Miles let Gary off too easily; Gary’s public statements all sound like “modern AI is mostly hype, it doesn’t really do anything like thinking”, but the bet is about things like “will AI make a Nobel Prize caliber scientific discovery by 2027?” and “will AI write Pulitzer-quality books by 2027?” I don’t blame Gary for taking the best terms he could find. But I am worried that if AI makes a Nobel-quality scientific discovery in 2026, but doesn’t quite write the Pulitzer-quality book, then Gary will get to claim victory over the AI optimists, whereas in fact that would be at probably the 95th percentile of fast timelines by most people’s estimate. 8: “The probability that cows (or other non-human animals) are experiencing constant bliss, lack tanha (craving, aversion, and the resulting suffering), or are "enlightened by default" is, by my estimation, very low”. 9: Recursive Adaptation (blog on addiction policy)’s predictions for 2025. 75% of FDA approval of GLP-1 for a substance use disorder by 2029! 10: In my post on the economics of GLP-1 receptor agonists (eg Ozempic), I wrote about how they’re currently widely available because of a loophole suspending patents during a shortage, and predicted there would be a big fight when the shortage was over. Sure enough, the FDA tried to declare that the shortage of tirzepatide (a next-generation Ozempic relative) was over, compounding pharmacies sued, and tirzepatide is still available while the issue goes through the courts (and will the administration have an opinion?) Also, compounding pharmacy access startup Mochi says that they will continue to prescribe even if the shortage is over, using another loophole saying doctors can do this for specific individual patients in cases of medical necessity. This is an extremely fake use of this loophole, but will the government be willing to call their bluff? 11: Jacob Falkovich has a blog on dating advice, which he plans to turn into a book of dating advice. I can’t really comment on the accuracy (my dating strategy tends to look more like waiting for women to send me emails saying “I like your blog, would you like to go on a date?” which probably doesn’t generalize), but I’ve had many good interactions with Jake, and he has a beautiful family which means he must be doing something right. Also, Jake is poly, and I sometimes wonder if poly people are the only ones qualified to give dating advice: if you’re monogamous, you either met your future spouse quickly (in which case you have no experience), dated for years without meeting your spouse (in which case you can’t be very good), or aren’t looking for a committed relationship at all (which is just pickup artistry, and follows very different dynamics). Poly people are the only ones who can break out of this trilemma! 12: Christ And Counterfactuals is a blog on effective altruism from a Christian perspective. Some previous attempts at this have felt kind of forced, but the first post I read here was actually pretty interesting. Richard Swinburne (apparently “the world’s best Christian philosopher”), thinks that: “[One] reason why it is good that the human race should sometimes be in an initial situation of considerable ignorance about the causes and effects of our actions, is this. If God abolished the need for rational inquiry and gave us from childhood strong true beliefs about the causes of things, that would make it too easy for us to make moral decisions. As things are in the actual world, most moral decisions are decisions taken in uncertainty about the consequences of our actions. I do not know for certain that if I smoke, I will get cancer; or that if I do not give money to some charity, people will starve. So we have to make our moral decisions on the basis of how probable it is that our actions will have various outcomes—how probable it is that I will get cancer if I continue to smoke (when I would not otherwise get cancer), or that someone will starve if I do not give. Since probabilities are so hard to assess, it is all too easy to persuade yourself that it is worth taking the chance that no harm will result from the less demanding decision (the decision which you have a strong desire to make). And even if you face up to a correct assessment of the probabilities, true dedication to the good is shown by doing the act which, although it is probably the best action, may have no good consequences at all.” (Could a Good God Permit so Much Suffering? A Debate, pp. 52-53.) This is pretty galaxy-brained, but something galaxy-brained must be going on for God to tolerate the existence of evil at all, and this is a surprisingly natural extension of some common premises on the subject. 13: Swedish study: diagnosing the marginal patient with a psychiatric condition makes their life worse. Of the two mechanisms they looked at, stigma seems more involved than drug side effects. My opinion: this study was done on conscripts undergoing a mandatory psych evaluation for the army, who had no previous reason to think they had a psych disease and had not sought treatment. This is a different situation from somebody who comes to a psychiatrist asking for relief from specific symptoms they have noticed. Also, Sweden c. 2005 is a different culture from America 2025 in terms of how much stigma a psych diagnosis carries. I think it’s possible that if you never considered that you had psychiatric problems, and were suddenly given a diagnosis in 2005 Sweden and told you couldn’t serve in the army, that’s likely to destabilize your self-image more than a person who knows they’re depressed going to a psychiatrist in 2025 US and getting antidepressants. 14: RIP Felix Hill, research scientist at DeepMind and mentor to many in the AI community. You can read his suicide note here, though the obvious content warning applies. He says he took ketamine for mild anxiety and it plunged him into an incredibly deep depression that he couldn’t get out of; he leaves his story behind as a warning for others. I appreciate his warning, but I wish he had said more about what dose he used; different people’s ketamine doses vary by almost two orders of magnitude, I’d previously thought that the low doses were pretty safe and the high doses were sketchy, and I would like to know whether I should update or not. 15: RIP Max Chiswick, professional poker player, effective altruist, and ACX reader. 16: Adrian Dittman, a Twitter account widely accused of being Elon Musk’s alt, has been revealed to be . . . a guy named Adrian Dittman. Congrats to Maia Crimew and the Spectator for actually investigating this, unlike many other news sources which spread the Musk conspiracy theory. Also, the people involved got banned from X for some reason, maybe because this qualified as doxxing Dittman. 17: Related: Musk claims to be among the top players in the world at several computer games. A veteran Path of Exile gamer presents evidence that Musk faked his PoE2 accomplishments by hiring a Chinese guy to play on his account. Some Musk supporters in the comments suggest that maybe he hires the Chinese guy to level up his account, but his accomplishments (eg speedruns) are still his own? 18: Related: Sam Harris says he has been friends with Musk since 2008, but he noticed a sudden shift for the worse in his personality around 2020 which made it impossible to stay friends with him. He gives the example of Musk losing a bet with him that there would be 35,000+ COVID cases in the US, refusing to pay up, and launching personal attacks on Sam when asked to do so. What happened? Some theories: Musk turned right-wing, which ended his friendship with Sam for the same reason political differences have always ended friendships (but then what about the bet, which seems like objectively bad behavior?)
Inline links: this, The Case For Clinical Trial Abundance, NYT article calculating your chance of winning the lottery, here, @venturetwins, this year’s results are in, Gary Marcus and Miles Brundage have made a bet about AI progress, @tamaybes, by my estimation, Recursive Adaptation, my post on, the FDA tried to declare, will continue to prescribe, a blog on dating advice, Christ And Counterfactuals, the first post I read here, diagnosing the marginal patient with a psychiatric condition makes their life worse, RIP, here, RIP, a guy named Adrian Dittman, got banned from X for some reason, presents evidence
Patient Zero1 mentions across 1 issues

Patient Zero is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between August 16, 2023 and August 16, 2023. The archive places it in contexts such as "an ex of mine might have been Patient Zero". It most often appears alongside Alice, Attack On Titan, Bali.

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Patient Zero
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August 16, 2023
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August 16, 2023
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In Defense Of Describable Dating Preferences
August 16, 2023 · Original source
The New York Times has an article on “dating docs”. These are a local phenomenon - I think an ex of mine might have been Patient Zero. I don’t begrudge the Times for writing about them. I’m just surprised they’re considered an interesting phenomenon. What could be more obvious than making sure potential dates know what you’re like?1
Inline links: an article on “dating docs”, 1
patria1 mentions across 1 issues

patria is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between May 06, 2021 and May 06, 2021. The archive places it in contexts such as "People were very proud of their city, their “patria”". It most often appears alongside 320 AD, 476 AD, Africa.

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patria
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1
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May 06, 2021
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May 06, 2021
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Your Book Review: Through The Eye Of A Needle
May 06, 2021 · Original source
Romans had a virtue, “vercundia”, knowing your place within the social pyramid and behaving accordingly. Those social pyramids existed within each city of the empire. People were very proud of their city, their “patria”. The empire felt much more a confederation of city-states than a modern nation-state. To be a citizen of a city was often the greatest honor in the life of a tenant farmer or a plebian. In Rome, the citizens of the city, the “plebs Romana,” were probably slightly less than half the population of the city. Yet, they were the only ones given the privileged of free grain and access to other foodstuff at reduced prices. “During times of famine, the plebs collaborated wholeheartedly with the Senate to drive strangers out of the city.” The plebs did not receive food privileges on the basis of need. “They received them because they were members of a privileged group.” The plebs of Roman and other cities were not “the poor”. They were the ancestral citizens of that city. “The primary division of society was not that between rich and poor but between citizens and non-citizens.”
Paxlovid1 mentions across 1 issues

Paxlovid is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between May 21, 2025 and May 21, 2025. The archive places it in contexts such as "Hydroxychloroquine, ivermectin, fluvoxamine, Paxlovid". It most often appears alongside 9/11, Afghanistan, Alina Chan.

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Paxlovid
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1
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1
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May 21, 2025
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May 21, 2025
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The Other COVID Reckoning
May 21, 2025 · Original source
Five years later, we can’t stop talking about COVID. Remember lockdowns? The conflicting guidelines about masks - don’t wear them! Wear them! Maybe wear them! School closures, remote learning, learning loss, something about teachers’ unions. That one Vox article on how worrying about COVID was anti-Chinese racism. The time Trump sort of half-suggested injecting disinfectants. Hydroxychloroquine, ivermectin, fluvoxamine, Paxlovid. Those jerks who tried to pressure you into getting vaccines, or those other jerks who wouldn’t get vaccines even though it put everyone else at risk. Anthony Fauci, Pierre Kory, Great Barrington, Tomas Pueyo, Alina Chan. Five years later, you can open up any news site and find continuing debate about all of these things.
Payment Protection Insurance1 mentions across 1 issues

Payment Protection Insurance is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between May 26, 2023 and May 26, 2023. The archive places it in contexts such as "He describes the UK's Payment Protection Insurance (PPI) mis-selling scandal". It most often appears alongside /r/wallstreetbets, 2013 Financial Services (Banking Reform) Act, 80,000 Hours.

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1
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1
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May 26, 2023
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May 26, 2023
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Your Book Review: Lying for Money
May 26, 2023 · Original source
As an example, he describes the UK's Payment Protection Insurance (PPI) mis-selling scandal. PPI is an insurance product designed to cover borrowers' loan or credit card repayments if they become ill, unemployed, deceased, or otherwise unable to earn income to make their payments. Davies comments on the reason that this new product offering likely seemed like a good idea to the bank managers who decided to start offering it in the early 1990s (and the reasons to be suspicious of it):
As always, the devil was in the details, with many bank branches selling a version of the product that Davies describes as "highly toxic": the PPI sold to many consumers was not as comprehensive as most consumers would have reasonably expected it to be. But banks controlled an important distribution channel (they could sell customers the Payment Protection Insurance at the same time that the consumer was applying for a loan), and thus banks would end up charging premiums roughly 4 times what an independent provider would have charged.
Paypal Mafia1 mentions across 1 issues

Paypal Mafia is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between September 04, 2023 and September 04, 2023. The archive places it in contexts such as "lacking a Paypal Mafia to join". It most often appears alongside Africa, Beyabu, Bildod.

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Paypal Mafia
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1
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1
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September 04, 2023
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September 04, 2023
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23: California Dreamin'
September 04, 2023 · Original source
Seen on the Praxis founder’s Twitter account. Milady is some kind of NFT thing, otherwise it makes as much sense to me as it does to you. But the other half of the paradox is the constant rumors that they’re competent and have some kind of good plan. These are spoken only in hushed whispers, I don’t know the details. But in 2021, they raised $4 million in a seed round from well-regarded venture capitalists whose investments usually make money. In 2022 they raised another $15 million in a Series A round from . . . okay, partly from Sam Bankman-Fried and Three Arrows Capital, two notorious crypto scammers. But you would think scammers would be extra careful not to invest their own money in scams! Also, they recently signed on David Weinreb, a completely normal (and well-regarded) city planner person. What’s the strategy that both involves both Milady Raves and lots of competent people agreeing you’re a good investment? One strategy is something like: buy some land somewhere. Build some houses and streets. Convince digital nomads to move there on the grounds that you are very cool and visionary. Do some cool and visionary seeming things, or at least throw some really good raves. Other digital nomads get jealous and move there too. Sell parcels of land to these people, get rich, pay back your investors. And then who knows, maybe create a new civilization that redefines what it means to be human. Consider Elon Musk. Elon Musk is good at certain business-related skills. But that’s not the essence of Elon Musk. The essence of Elon Musk is that he’s a Visionary who can bring the Glorious Future. We know this because he’s a crazy person who says stuff that doesn’t really make sense. When Elon Musk buys a company, its value goes up - maybe partly because people expect Musk to make good business decisions, but also partly because now the company is part of Musk’s Glorious Future, and therefore exciting. Employees, customers, and investors all get excited and reinforce each other in a virtuous circle. And although Musk might not always accomplish the exact Glorious Future future he promises, his companies do well and make money, because having motivated employees, star-struck customers, and willing investors is a great combination. Elon Musk has an aura of destiny because he succeeded at his first several companies. Dryden Brown of Praxis Society, lacking a Paypal Mafia to join, is trying to hack together an aura of destiny out of raves and angel-related videos. So far it seems to be going pretty okay. Prospera Sues Honduras For 2/3 Of Its National Budget To refresh: in the mid-2010s Honduras’ pro-market government created ZEDEs - businesses that bought up unoccupied land could start their own districts with their own preferred legal system in exchange for bringing in investment. The government knew businesses wouldn’t invest long-term if the next government could just cancel the agreement and seize all of their stuff, so they fortified the law with as much protection as possible. It would take a long constitutional amendment process to repeal, and ZEDE investors might be able to object to any changes under international investment treaties. Lured by these protections, three companies started ZEDEs, including a big high-profile one called Prospera. In early 2022, a socialist government took power, and started trying their best to destroy the ZEDEs. They started the constitutional amendment process (they seem to think they’ve finished it, but a Prospera rep I talked to believe they have to hold another vote by the end of this year, something I see no signs of them doing) and have been harassing and stonewalling existing ZEDEs. One ZEDE, Orquidea, shut down immediately. A second, Ciudad Morazan, seems to still be operating but I cannot figure out exactly how or why. Prospera has been most vocal in its opposition, and sued Honduras for $11 billion in the World Bank’s court of investment arbitration. (Prospera has only spent about $100 million so far, so it’s unclear why they deserve 100x that in penalties. Also $11 billion is “two-thirds of the 2022 Honduran national budget”, and forcing Honduras to pay it would cause national catastrophe. This might be more of a highball offer than a number they actually expect to get.) This article (poorly translated from Spanish, sorry) has the most information. It suggests Honduras believes they signed onto the investment treaties “with reservations”, ie conditional on being allowed to do things like shut down ZEDEs, and that therefore the suit is meaningless and they will not defend themselves. Although the magazine is on the government’s side of the overall issue, it suggests they didn’t actually sign on with reservations, that the country’s lawyers might just have no idea what they’re talking about, and that their bold strategy of refusing to defend themselves will not pay off. In contrast, Prospera has prestigious lawyers specializing in exactly this area, so things aren’t looking good for the government. Honduras seems to recognize this and is threatening to withdraw from ICSID, the international investment treaty that governs such disputes. This wouldn’t be completely unprecedented - Venezuela, Bolivia, and Ecuador have also done this. But ICSID rules say that withdrawing from ICSID, while it might help prevent future cases against you, doesn’t cancel existing cases, and wouldn’t protect Honduras against Prospera’s claim. (How would ICSID collect against Honduras if they lost? I don’t know, but I assume the global financial order has some way to make your life worse if you defy it.) I think everyone is hoping Honduras realizes that cancelling a flourishing economic zone that’s bringing lots of investment into the country at no cost to them - just isn’t worth taking an $11 billion loss, cancelling international treaties, and scaring off future investment. But who knows how these people think? In other Prospera news: Prospera announces another $36 million in recent investment, which I take as evidence that VCs with good lawyers and research departments also think its case is very strong.
Inline links: the Praxis founder’s Twitter account, raised $4 million in a seed round, raised another $15 million in a Series A round, recently signed on David Weinreb, To refresh:, harassing and stonewalling, sued Honduras for $11 billion, This article, threatening to withdraw from ICSID, Venezuela, Bolivia, and Ecuador have also done this, announces another $36 million in recent investment
PBR1 mentions across 1 issues

PBR is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between January 19, 2022 and January 19, 2022. The archive places it in contexts such as "health economics ... medical systems ... based on three-letter acronyms (did you know PBR financing in the NHS ...)". It most often appears alongside Alinea, Alp Blossom, Alpha Tolman.

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PBR
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Book Review: Which Country Has The World's Best Health Care?
January 19, 2022 · Original source
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PCM1 mentions across 1 issues

PCM is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between September 20, 2021 and September 20, 2021. The archive places it in contexts such as "Rage Comic Guys/Wojaks/4chan/Reddit/PCM are creating a new symbolic online language". It most often appears alongside 4chan, A Clockwork Orange, Adrenochrome.

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PCM
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Links For September
September 20, 2021 · Original source
26: People have commented before on how Rage Comic Guys/Wojaks/4chan/Reddit/PCM are creating a new symbolic online language, but I didn’t appreciate it fully until I read this Greek mythology 6x6 Wojak compass mapping the new archetypes on to the old. Warning: very high-context.
Inline links: this Greek mythology 6x6 Wojak compass
PCR1 mentions across 1 issues

PCR is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between November 17, 2021 and November 17, 2021. The archive places it in contexts such as "entire control group had positive PCRs on day 10". It most often appears alongside ACE-2 receptor, ACSH, Ahmed et al.

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Ivermectin: Much More Than You Wanted To Know
November 17, 2021 · Original source
Click to expand. # is how many people were in the smallest relevant group (eg if there were 20 people in placebo and 10 in ivermectin, it was 10). Dose is ivermectin dose x number of days. Tested w/ is what drugs were given alongside ivermectin; compare is what drugs were in the “placebo” group (I excluded some very common things like paracetamol). %-PCR7 is what percent of patients had a negative PCR test (indicating recovery) after 7 days (though if 7 wasn’t available, I accepted anything from 6-12); the (I) and (P) are ivermectin and placebo groups. R is the ratio - green if statistically significant, red otherwise. DaysPCR is how many days it took to get a negative PCR test. Days to -sym are how many days it took symptoms to resolve. -outc is some serious negative outcome in the study, either clinical worsening, hospitalization, or death. I was inconsistent which one I chose, trying to pick whichever I thought struck a balance between high sample size and severity. Since this was almost never significant, I made it blue if it favored ivermectin and orange if it favored placebo (which it never did; there is no orange). Lowest p is the lowest p-value in the study for one of the headline results. 1o+ is whether the primary outcome was positive or not. I made this very quickly and unprincipledly and I am sure there are a lot of errors; please forgive me. Of studies that included any of the endpoints I recorded, ivermectin had a statistically significant effect on the endpoint 13 times, and failed to reach significance 8 times. Of studies that named a specific primary endpoint, 9 found ivermectin affected it significantly, and 12 found it didn’t. But that’s still pretty good. And “doesn’t affect to a statistically significant degree” doesn’t mean it doesn’t work. It might just mean your study is too small for a real and important effect to achieve statistical significance. That’s why people do meta-analyses to combine studies. And the ivmmeta people say they did that and it was really impressive. All of this is still basically what things would look like if ivermectin worked. But of course we can’t give every study one vote. We’ve got to actually look at these and see which ones are good and which ones are bad. So, God help us, let’s go over all thirty of the ivermectin studies in this top panel of ivmmeta.com. (if you get bored of this, scroll down to the section called “The Analysis”) The Studies Elgazzar et al: This one isn’t on the table above, but we can’t start talking about the others until we get it out of the way. 600 Egyptian patients were randomized into six groups, including three that got ivermectin. The ivermectin groups did substantially better: for example, 2 vs. 20 deaths in ivermectin group 3 vs. non-ivermectin group 4. There were various other equally impressive outcomes. Unfortunately, it’s all false. Some epidemiologists and reporters were able to obtain the raw data (it was password-protected, but the password was “1234”), and it was pretty bizarre. Some patients appeared to have died before the trial started; others were arranged in groups of four such that it seemed like the authors had just copy-pasted the same four patients again and again. Probably either the study never happened, or at least the data were heavily edited afterwards. You can read more here. A lot of the apparent benefit of ivermectin in meta-analyses disappeared after taking out this paper (though remember, this isn’t even on the table at the top of the post, so it doesn’t directly affect that). Since the Elgazzar debacle, a group of researchers including Gideon Meyerowitz-Katz, Kyle Sheldrake, James Heathers, Nick Brown, Jack Lawrence, etc, have been trying to double-check as many other ivermectin studies as possible. At least three others - Samaha, Carvallo, and Niaee - have similar problems and have been retracted. Those studies were all removed before I screenshotted the table above, and they’re not on there. But everybody is pretty paranoid right now and looking for fraud a lot harder than they might be in normal situations. Moving on: Chowdury et al: Bangladeshi RCT. 60 patients in Group A got low-dose ivermectin plus the antibiotic doxycycline, 56 in Group B got hydroxychloroquine (another weird COVID treatment which most scientists think doesn’t work) plus the antibiotic azithromycin. No declared primary outcome. Ivermectin group got to negative PCR a little faster than the other (5.9 vs. 7 days) but it wasn’t statistically significant (p = 0.2). A couple of other non-statistically-significant things happened too. 2 controls were hospitalized, 0 ivermectin patients were. This is a boring study that got boring results, so nobody has felt the need to assassinate it, but if they did, it would probably focus on both groups getting various medications besides ivermectin. None of these other medications are believed to work, so I don’t really care about this, but you could tell a story where actually doxycycline works great at addressing associated bacterial pneumonias, or where HCQ causes lots of side effects and that makes the ivermectin group look good in comparison, or whatever. Espitia-Hernandez et al: Mexican trial which is probably not an RCT - all it says is that “patients were voluntarily allocated”. 28 ended up taking a cocktail of low-dose ivermectin, vitamin D, and azithromycin; 7 were controls. On day ten, everyone (!) in the experimental group was PCR negative; everyone (!) in the control group was still positive. Also, symptoms in the experimental group lasted an average of three days; in the control group, more like 10. These results make ivermectin look amazingly super-good, probably better than any other drug for any other disease, except maybe stuff like vitamins for treatment of vitamin deficiency. Any issues? We don’t know how patients were allocated, but they discuss patient characteristics and they don’t look different enough to produce this big an effect size. The experimental group got a lot of things other than ivermectin, but I would be equally surprised if vitamin D or azithromycin cured COVID this effectively. It deviated from its preregistration in basically every way possible, but you shouldn’t be able to get “every experimental patient tested negative when zero control patients did” by garden-of-forking-paths alone! But this has to be false, right? Even the other pro-ivermectin studies don’t show effects nearly this big. In all other studies combined, ivermectin patients took an average of 8 days to recover; in Espitia-Hernandez, they took 3. Also, it’s pretty weird that the entire control group had positive PCRs on day 10 - in most other studies, a majority of people had negative PCRs by day 7 or so, regardless of whether they were control or placebo. Everything about this is so shoddy that I can easily believe something went wrong here. I don’t have a great understanding of this one but I don’t trust it at all. Luckily it is small and non-randomized so it will be easy to ignore going forward. I’m not saying this is related, but I’m not saying it *isn’t* related either. Carvallo et al: This one has all the disadvantages of Espitia-Hernandez, plus it’s completely unreadable. It’s hard to figure out how many patients there were, whether it was an RCT or not, etc. It looks like maybe there were 42 experimentals and 14 controls, and the controls were about 10x more likely to die than the experimentals. Seems pretty bad. On the other hand, another Carvallo paper was retracted because of fraud: apparently the hospital where the study supposedly took place said it never happened there. I can’t tell if this is a different version of that study, a pilot study for that study, or a different study by the same guy. Anyway, it’s too confusing to interpret, shows implausible results, and is by a known fraudster, so I feel okay about ignoring this one. Mahmud et al: RCT from Bangladesh. 200 patients received ivermectin plus doxycycline, 200 received placebo. Everything was written up very nicely in real English, by people who were clearly not on 34 lbs of meth at the time. They designated a primary outcome, “number of days required for clinical recovery”, and found a statistically significant difference at p < 0.001: Okay, fine, they misspelled “recovery” once. But they spelled it right the other time! That puts it in the top 50% for ivermectin papers! The fraud-hunters have examined this paper closely and are unable to find any signs of fraud. @PubPeer on the Mahmud trial of ivermectin in covid patients.\n\nI have now reviewed the individual patient data master sheet.\n\nI did not find any irregularities and the summary data matches the published data.\n\n","username":"K_Sheldrick","name":"Kyle Sheldrick","profile_image_url":"","date":"Sat Jul 17 11:06:25 +0000 2021","photos":[],"quoted_tweet":{},"reply_count":0,"retweet_count":2,"like_count":12,"impression_count":0,"expanded_url":{"url":"https://pubpeer.com/publications/E1D65711EF28D14517731BEACB89C8#2","title":"PubPeer - Ivermectin in combination with doxycycline for treating COVI...","description":"There are comments on PubPeer for publication: Ivermectin in combination with doxycycline for treating COVID-19 symptoms: a randomized trial (2021)","domain":"pubpeer.com"},"video_url":null,"belowTheFold":true}" data-component-name="Twitter2ToDOM"> I think this paper is legitimate and that its findings need to be seriously considered. Serious consideration doesn’t always meant they’re true - sometimes if we have strong evidence otherwise we can dismiss things without understanding why. And there’s always the chance it was a fluke, right? Can something have a p-value less than 0.001 and still be a fluke? Szenta Fonseca et al: This is a chart review from Brazil. Researchers looked at various people who had been treated for COVID in an insurance company database, saw whether they got ivermectin or not, and saw whether the people who got it did better or worse. About a hundred people got it, and a few hundred others didn’t. The people who got it did not do any better than anyone else, and you’ll notice this is one of the rare red boxes on the table above. But we shouldn’t take this study seriously. Nobody took any effort to avoid selection bias, so it’s very possible that sicker people were given more medication (including ivermectin), which unfairly handicaps the ivermectin group. Also, it’s hard to tell from the paper who was on how much of what, and the discussion of ivermectin seems like kind of an afterthought after discussing lots of other meds in much more depth. This is another one I feel comfortable ignoring. Cadegiani et al: A crazy person decided to put his patients on every weird medication he could think of, and 585 subjects ended up on a combination of ivermectin, hydroxychloroquine, azithromycin, and nitazoxanide, with dutasteride and spironolactone "optionally offered" and vitamin D, vitamin C, zinc, apixaban, rivaraxoban, enoxaparin, and glucocorticoids "added according to clinical judgment". There was no control group, but the author helpfully designated some random patients in his area as a sort-of-control, and then synthetically generated a second control group based on “a precise estimative based on a thorough and structured review of articles indexed in PubMed and MEDLINE and statements by official government agencies and specific medical societies”. Patients in the experimental group were twice as likely to recover (p < 0.0001), had negative PCR after 14 vs. 21 days, and had 0 vs. 27 hospitalizations. Speaking of low p-values, some people did fraud-detection tests on another of Cadegiani’s COVID-19 studies and got values like p < 8.24E-11 in favor of it being fraudulent. And, uh, he’s also studied whether ultra-high-dose antiandrogens treated COVID, and found that they did, cutting mortality by 92% . But the trial is under suspicion, with a BMJ article calling it “[the worst] violations of medical ethics and human rights in Brazil’s history” and “an ethical cesspit of violations”. [update 2022: this section originally contained more accusations against Cadegiani. Alexandros Marinos does a deeper dive with information not available at the time I wrote this, and finds some of them were overstated or false by implication] Anyway, let’s not base anything important on the results of this study, mmkay? A defiant Flavio Cadegiani. Imagine a guy who looks like this telling you to take ultra-high-dose antiandrogens. Ahmed et al: And we’re back in Bangladesh. 72 hospital patients were randomized to one of three arms: ivermectin only, ivermectin + doxycycline, and placebo. Primary endpoint was time to negative PCR, which was 9.7 days for ivermectin only and 12.7 days for placebo (p = 0.03). Other endpoints including duration of hospitalization (9.6 days ivermectin vs. 9.7 days placebo, not significant). This looks pretty good for ivermectin and does not have any signs of fraud or methodological problems. If I wanted to pick at it anyway, I would point out that the ivermectin + doxycycline group didn’t really differ from placebo, and that if you average out both ivermectin groups (with and without doxycycline) it looks like the difference would not be significant. I had previously committed to considering only ivermectin alone in trials that had multiple ivermectin groups, so I’m not going to do this. I can’t find any evidence this trial was preregistered so I don’t know whether they waited to see what would come out positive and then made that their primary endpoint, but virological clearance is a pretty normal primary endpoint and this isn’t that suspicious. It’s impossible to find any useful commentary on this study because Elgazzar (the guy who ran the most famous fraudulent ivermectin study) had the first name Ahmed, everyone is talking about Elgazzar all the time, and this overwhelms Google whenever I try to search for Ahmed et al. For now I’ll just keep this as a mildly positive and mildly plausible virological clearance result, in the context of no effect on hospitalization length or most symptoms. Chaccour et al: 24 patients in Spain were randomized to receive either medium-dose ivermectin or placebo. The primary outcome was percent of patients with negative PCR at day 7; secondary outcomes were viral load and symptoms. The primary endpoint ended up being kind of a wash - everyone still PCR positive by day 7 so it was impossible to compare groups. Ivermectin trended toward lower viral load but never reached significance. Weirdly, ivermectin did seem to help symptoms, but only anosmia and cough towards the end (p = 0.03), which you would usually think of as lingering post-COVID problems. The paper says: Given these findings, consideration could be given to alternative mechanisms of action different from a direct antiviral effect. One alternative explanation might be a positive allosteric modulation of the nicotinic acetylcholine receptor caused by ivermectin and leading to a downregulation of the ACE-2 receptor and viral entry into the cells of the respiratory epithelium and olfactory bulb. Another mechanism through which ivermectin might influence the reversal of anosmia is by inhibiting the activation of pro-inflammatory pathways in the olfactory epithelium. Inflammation of the olfactory mucosa is thought to play a key role in the development of anosmia in SARS-CoV-2 infection This seems kind of hedge-y. If you’re wondering where things went from there, Dr. Chaccour is now a passionate anti-ivermectin activist: @Finneganporter in @BusinessInsider \n\nThe roots of #ivermectin mania: How South America incubated a fake-medicine craze that took the US by storm\n\n","username":"carlos_chaccour","name":"Dr. Carlos Chaccour ??????","profile_image_url":"","date":"Sun Nov 07 18:40:28 +0000 2021","photos":[],"quoted_tweet":{},"reply_count":0,"retweet_count":2,"like_count":9,"impression_count":0,"expanded_url":{"url":"https://www.businessinsider.in/international/news/the-roots-of-ivermectin-mania-how-south-america-incubated-a-fake-medicine-craze-that-took-the-us-by-storm/articleshow/87554081.cms","image":"https://bucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com/public/images/88d08e70-c9e2-46d4-a5df-96807b6c3a13_2000x1000.jpeg","title":"The roots of ivermectin mania: How South America incubated a fake-medicine craze that took the US by storm","description":"The popularity of unproven anti-parasitic drug ivermectin as a COVID-19 treatment is surging. Its use has roots in South America, where it was hyped by populist","domain":"businessinsider.in"},"video_url":null,"belowTheFold":true}" data-component-name="Twitter2ToDOM"> So I guess he must think of this trial as basically negative, although realistically it’s 24 people and we shouldn’t put too much weight on it either way. Ghauri et al: Pakistan, 95 patients. Nonrandom; the study compared patients who happened to be given ivermectin (along with hydroxychloroquine and azithromycin) vs. patients who were just given the latter two drugs. There’s some evidence this produced systematic differences between the two groups - for example, patients in the control group were 3x more likely to have had diarrhea (this makes sense; diarrhea is a potential ivermectin side effect, so you probably wouldn’t give it to people already struggling with this problem). Also, the control group was twice as likely to be getting corticosteroids, maybe a marker for illness severity. Primary outcome was what percent of both groups had a fever: on day 7 it was 21% of ivermectin patients vs. 65% of controls, p < 0.001. No other outcomes were reported. I don’t hate this study, but I think the nonrandom assignment (and observed systematic differences) is a pretty fatal flaw. I can’t find anyone else talking about this one. At least no one seems to be saying anything bad. Babaloba et al: Be warned: if I have to refer to this one in real-life conversation, I will expand out the “et al” and call it “Babalola & Alakoloko”, because that’s really fun to say. This was a Nigerian RCT comparing 21 patients on low-dose ivermectin, 21 patients on high-dose ivermectin, and 20 patients on a combination of lopinavir and ritonavir, a combination antiviral which later studies found not to work for COVID and which might as well be considered a placebo. Primary outcome, as usual, was days until a negative PCR test. High dose ivermectin was 4.65 days, low dose was 6 days, control was 9.15, p = 0.035. Figure 2 is apparently a photograph of the computer screen where they did this calculation. Gideon Meyerowitz-Katz, part of the team that detects fraud in ivermectin papers, is not a fan of this one: He doesn’t say there what means, but elsewhere he tweets this figure: It’s always a bad sign when your study features in an image with “NUMEROUS IMPOSSIBLE NUMBERS” in red at the top. I think his point is that if you have 21 people, it’s impossible to have 50% of them have headache, because that would be 10.5. If 10 people have a headache, it would be 47.6%; if 11, 52%. So something is clearly wrong here. Seems like a relatively minor mistake, and Meyerowitz-Katz stops short of calling fraud, but it’s not a good look. I’m going to be slightly uncomfortable with this study without rejecting it entirely, and move on. Ravakirti et al: Here we’re in Eastern India - not exactly Bangladesh again, but a stone’s throw away from it. In this RCT patients were randomized into an ivermectin group (57) and a placebo group (58). Primary outcome was negative PCR on day 6, because doing it on day 7 like everyone else would be too easy. As with several other groups, this was a bad move; too few people had it to make a good comparison; it was 13% of intervention vs. 18% of placebo, p = 0.3. Secondary outcomes were also pretty boring, except for the most important: 4 people in the placebo group died, compared to 0 in ivermectin (p = 0.045). On the one hand, this is one outcome of many, reaching the barest significance threshold. Another fluke? Still, there are no real problems with this study, and nobody has anything to say against it. Let’s add this one to the scale as another very small and noisy piece of real evidence in ivermectin’s favor. Bukhari et al: Now we’re in Pakistan. 50 patients were randomized to low-dose ivermectin, another 50 got standard of care including vitamin D. There was no placebo, but primary outcome was number of days to reach negative PCR, which it seems hard for placebo to affect much, so I don’t care. 5 controls and 9 ivermectin patients left the hospital against medical advice and could not be followed up, which is bad but not necessarily study-ruining. They never measured their supposed primary outcome of “days to reach negative PCR” directly, but they did measure how many people had negative PCR on various days, and ivermectin had a clear advantage - for example, on day 7, it was 37/50 for IVR and only 20/50 for control. Even if we assume all the lost-to-followup patients had maximally bad-for-the-hypothesis results, that’s still a positive finding. Nobody else has much to say about this one, certainly no accusations that they’ve found anything suspicious. Keep. Mohan et al: India. RCT. 40 patients got low-dose ivermectin, 40 high-dose ivermectin, and 45 placebo. Primary outcomes were time to negative PCR, and viral load on day 5. In the results, they seem to have reinterpreted “time to negative PCR” as the subtly different “percent with negative PCR on some specific day”. High-dose ivermectin did best (47.5% negative on day 5) and placebo worst (31% negative), but it was insignificant (p = 0.3). There was no difference in viral load. All groups took about the same amount of time for symptoms to resolve. More placebo patients had failed to recover by the end of the study (6) than ivermectin patients (2), but this didn’t reach statistical significance (p = 0.4). Overall a well-done, boring, negative study, although ivermectin proponents will correctly point out that, like basically every other study we have looked at, the trend was in favor of ivermectin and this could potentially end up looking impressive in a meta-analysis. Biber et al: This is an RCT from Israel. 47 patients got ivermectin and 42 placebo. Primary endpoint was viral load on day 6. I am having trouble finding out what happened with this; as far as I can tell it was a negative result and they buried it in favor of more interesting things. In a "multivariable logistic regression model, the adjusted odds ratio of negative SARS-CoV-2 RT-PCR negative test" favored ivermectin over placebo (p = 0.03 for day 6, p = 0.01 for day 8), but this seems like the kind of thing you do when your primary outcome is boring and you’re angry. Gideon Meyerowitz-Katz is not a fan: He notes that the study excluded people with high viral load, but the preregistration didn’t say they would do that. Looking more closely, he finds they did that because, if you included these people, the study got no positive results. So probably they did the study, found no positive results, re-ran it with various subsets of patients until they did get a positive result, and then claimed to have “excluded” patients who weren’t in the subset that worked. I’m going to toss this one. Elalfy et al: What even is this? Where am I? As best I can tell, this is some kind of Egyptian trial. It might or might not be an RCT; it says stuff like “Patients were self-allocated to the treatment groups; the first 3 days of the week for the intervention arm while the other 3 days for symptomatic treatment”. Were they self-allocated in the sense that they got to choose? Doesn’t that mean it’s not random? Aren’t there seven days in a week? These are among the many questions that Elalfy et al do not answer for us. The control group (which they seem to think can also be called “the white group”) took zinc, paracetamol, and maybe azithromycin. The intervention group took zinc, nitazoxanide, ribavirin, and ivermectin. There were very large demographic differences between the groups of the sort which make the study unusable, which they mention and then ignore. From there, they follow this normal and totally comprehensible flowchart: There is no primary outcome assigned, but viral clearance rates on day seven were 58% in the yellow group compared to 0% in the white group, which I guess is a strong positive result. This table… …looks very impressive, in terms of the experimental group doing better than the control, except that they don’t specify whether it was before the trial or after it, and at least one online commentator thinks it might have been before, in which case it’s only impressive how thoroughly they failed to randomize their groups. Overall I don’t feel bad throwing this study out. I hope it one day succeeds in returning to its home planet. Lopez-Medina et al: Colombian RCT. 200 patients took ivermectin, another 200 took placebo. They originally worried the placebo might taste different than real ivermectin, then solved this by replacing it with a different placebo, which is a pretty high level of conscientiousness. Primary outcome was originally percent of patients whose symptoms worsened by two points, as rated on a complicated symptom scale when a researcher asked them over the phone. Halfway through the study, they realized nobody was worsening that much, so they changed the primary outcome to time until symptoms got better, as measured by the scale. In the ivermectin group, symptoms improved that much after 10 days; in the placebo group, after 12, p = 0.53. By the end of the study, symptoms had improved in 82% of ivermectin users and 79% of controls, also insignificant. 4 patients in the ivermectin group needed to be hospitalized compared to 6 in the placebo group, again insignificant. This study is bigger than most of the other RCTs, and more polished in terms of how many spelling errors, photographs of computer screens, etc, it contains. It was published in JAMA, one of the most prestigious US medical journals, as opposed to the crappy nth-tier journals most of the others have been in. When people say things like “sure, a lot of small studies show good results for ivermectin, but the bigger and more professional trials don’t”, this is one of the two big professional trials they’re talking about. Ivermectin proponents make some good arguments against it. In order to get as big as it did, Lopez-Medina had to compromise on rigor. Its outcome is how people self-score their symptoms on a hokey scale in a phone interview, instead of viral load or PCR results or anything like that. Still, this is basically what we want, right? In the end, we want people to feel better and less sick, not to get good scores on PCR tests. Also, it changed its primary outcome halfway through; isn’t that bad? I think maybe not; the reason we want a preregistered primary outcome is so that you don’t change halfway through to whatever outcome shows the results you want. The researchers in this study did a good job explaining why they changed their outcome, the change makes sense, and their original outcome would also have shown ivermectin not working (albeit less accurately and effectively). I don’t know of any evidence that they knew (or suspected) final results when switching to this new outcome, and it seems like the most reasonable new outcome to switch to. Finally, their original placebo tasted different from ivermectin (though they switched halfway through). This is one of the few studies where I actually care about placebo, because people are self-rating their symptoms. But realistically most of these people don’t know what ivermectin is supposed to taste like. Also, they did a re-analysis and found there was no difference between the people who got the old placebo and the new one. I’m making a big deal of this because ivmmeta.com - the really impressive meta-analysis site I’ve been going off of - puts a special warning letter underneath their discussion of this study, urging us not to trust it. They don’t do this for any of the other ones we’ve addressed so far - not the one by the guy whose other studies were all frauds, not the one where 50% of 21 people had headaches, not the unrandomized one where the groups were completely different before the experiment started, not even the one by the guy accused of crimes against humanity. Only this one. This makes me a lot less charitable to ivmmeta than I would otherwise be; I think it’s hard to choose this particular warning letter strategy out of well-intentioned commitment to truth. They just really don’t like this big study that shows ivermectin doesn’t work. Also, the warning itself irritates me, and includes paragraphs like: RCTs have a fundamental bias against finding an effect for interventions that are widely available — patients that believe they need treatment are more likely to decline participation and take the intervention [Yeh], i.e., RCTs are more likely to enroll low-risk participants that do not need treatment to recover (this does not apply to the typical pharmaceutical trial of a new drug that is otherwise unavailable). This trial was run in a community where ivermectin was available OTC and very widely known and used. Nobody else worries about this, and there are a million biases that non-randomized studies have that would be super-relevant when discussing those, but somehow when they’re pro-ivermectin the site forgets to be this thorough. I think a better pro-ivermectin response to this study is to point out that all the trends support ivermectin. Symptoms took 10 days to resolve in the ivermectin group vs. 12 in placebo; 4 ivermectin patients were hospitalized vs. 6 placebo patients, etc. Just say that this was an unusually noisy trial because of the self-report methodology, and you’re confident that these small differences will add up to significance when you put them into a meta-analysis. Roy et al: We’re back in East India, and back to non-randomized trials. 56 patients were retrospectively examined; some had been given ivermectin + doxycycline, others hydroxychloroquine, other azithromycin, and others symptomatic treatment only. We don’t get any meaningful information about how this worked, but we are told that they did not differ in “clinical well-being reporting onset timing”. Whatever. Chahla et al: The first of many Argentine trials. 110 patients received medium-dose ivermectin; 144 were kept as a control (no placebo). This was “cluster randomized”, which means they randomize different health centers to either give the experimental drug or not. This is worse than regular randomization, because there could be differences between these health centers (eg one might have better doctors who otherwise give better treatment, one might be in the poor part of town and have sicker patients, etc). They checked to see if there were any differences between the groups, and it sure looks like there were (the experimental group had twice as many obese people as the controls), but as per them, these differences were not statistically significant. Note that if this did make a difference, it would presumably make ivermectin look worse, not better. The primary outcome was given as “increase discharge from outpatient care with COVID-19 mild disease”. This favored the treatment; only 2/110 patients in the ivermectin group failed to be discharged, compared to 20 patients in the control group. But, uh, these were at different medical centers. Can’t different medical centers just have different discharge policies? One discharges you as soon as you seem to be getting better, the other waits to really make sure? This is an utterly crap endpoint to do a cluster randomized controlled trial on. If you’re going to do cRCT, which is never a great idea, you should be using some extremely objective endpoint that doctors and clinic administrators can’t possibly affect, like viral load according to some third-party laboratory, using the same third-party laboratory for both clinics. This is such a bad idea that I can’t help worrying I’m missing or misunderstanding something. If not, this is dumb and bad and should be ignored. Mourya et al: We’re back in India. This is a nonrandomized study comparing 50 patients given ivermectin to 50 patients given hydroxychloroquine. No primary outcome was named, but they focus on PCR negativity. Only 6% of patients in the hydroxychloroquine group were negative, compared to 90% of patients in the ivermectin group! On what day did they do the test? Uh, kind of random, and they admit that “in [the hydroxychloroquine group], mean time difference from the date of initiation of treatment and second test was significantly longer (7.24±2.75 days) as compared to 5.22±1.21 days in [the ivermectin group] (p=0.021).” Since they assessed these groups at different times, we shouldn’t draw any conclusions from them getting different results. Except that as far as I can tell this should handicap ivermectin, making it especially impressive that it did better. But also, the ivermectin group was made mostly of people who had been asymptomatic at the beginning (70%), and the hydroxychloroquine group had almost no asymptomatic cases (8%) . They were giving the ivermectin to healthy people and the hydroxychloroquine to sick people! They admit deep in the discussion that this “may be a confounding factor”. So basically they got totally different groups of people, tested them at totally different times, and the two sets of test results differed. So what? So this is why normal people do RCTs instead of whatever the heck this is, that’s what. Loue et al: …this one isn’t going to be an RCT either. Loue tells a story about a cluster of COVID cases at the French nursing home where he works. He asked people if they wanted to try ivermectin; 10 did and 15 didn’t. 1 ivermectin patient died, compared to 5 non-ivermectin patients. The non-ivermectin group looked a bit sicker than the ivermectin group in the inevitable Table 1, though it’s hard to tell. One interesting possible confounder (not mentioned, but I’m imagining it) is that demented patients probably couldn’t consent to ivermectin and ended up in the control group. This is another case of “I’m not going to trust anything that isn’t an RCT”. Merino et al: Another (sigh) non-RCT. Mexico City tried a public health program where if you called a hotline and said you had COVID, they sent you an emergency kit with various useful supplies. One of those supplies was ivermectin tablets. 18,074 people got the kit (and presumably some appreciable fraction took the ivermectin, though there’s no way to prove that). Their control group is people from before they started giving out the kits, people from after they stopped giving out the kits, and people who didn’t want the kits. There are differences in who got COVID early in the epidemic vs. later, and in people who did opt for medical kits vs. didn’t. To correct these, the researchers tried to adjust for confounders, something which - as I keep trying to hammer home again and again - never works. They found that using the kit led to a 75% or so reduction in hospitalization, though they were unable to separate out the ivermectin from the other things in the kit (paracetamol and aspirin), or from the placebo effect of having a kit and feeling like you had already gotten some treatment (if I understand right, the decision to go to the hospital was left entirely to the patient). I think this study is a moderate point in favor of giving people kits in order to prevent hospital overcrowding, but I’m not willing to accept that it tells us much about ivermectin in particular. Faisal et al: This one was published in The Professional Medical Journal (mispelled as “Profesional Medical Journal” in its URL), so you know it’s going to be good! It describes itself as “a cross-sectional study”, but later says it “randomized patients into two groups”, which would make it an RCT - I think they might just be using the term “cross-sectional” different from the standard American usage. A hospital in Pakistan got 50 patients on ivermectin + azithromycin, and another 50 on azithromycin alone. Primary outcome was not mentioned, and the data were presented confusingly, but a typical result is that only 4% of the ivermectin group had symptoms lasting more than 10 days, whereas 16% of the control group did, p < 0.01. They do a really weird thing where they compare how long it took symptoms to resolve between IVM and control groups within each bin. That is, if I’m understanding correctly, they ask “of the people who took between 3-5 days for symptoms to resolve, did they resolve faster for IVM or control?”. This is an utterly bizarre analysis to perform, although it doesn’t affect the fact that their other results still seem to favor ivermectin. Maybe I’m confused about what’s going on here. I’ve mostly been letting people off easy on no placebo, but I as far as I can tell (not very far) this paper seems to be going off whether patients reported continuing to have symptoms to the hospital doing the study, and I think that is potentially susceptible to placebo effects. Additionally, there’s no preregistration, and even though they talk a lot about doing PCR tests they don’t present the results. This is by no means the worst study here but I still think it’s pretty low quality and I don’t trust it. Aref et al: This one is published in the International Journal Of Nanomedicine, even though I’m pretty sure that isn’t a real thing. In this case the “nanomedicine” is a new nasal spray version of ivermectin which is so confusing I cannot for the life of me figure out what dose they are giving these patients. This Egyptian study gives 57 patients intranasal ivermectin plus hydroxychloroquine, azithromycin, oseltamavir, and some vitamins; another 57 patients get all that stuff except the ivermectin. Primary outcome is not stated, but they look at various symptoms, all of which look better in the ivermectin group: 95% of ivermectin patients got negative PCRs at some time point, compared to 75% of controls, p = 0.004. I am pretty suspicious of this study, not least because it comes from Egypt which has an awful reputation for fake studies, and it returns extreme results that I wouldn’t expect even if ivermectin was actually a wonder drug. But I cannot find any particular thing wrong with it, nor did anyone else I looked at, so I will grudgingly let it stand. Krolewiecki et al: Another Argentine study. This one is a real RCT. 30 patients received ivermectin, 15 were the control group (no placebo, again). Primary outcome was difference in viral load on day 5. The trend favored ivermectin but it was not statistically significant, although they were able to make it statistically significant if they looked at a subset of higher-IVM-plasma-concentration patients. They did not find any difference in clinical outcomes. A pro-ivermectin person could point out that in the subgroup with the highest ivermectin concentrations, the drug seemed to work. A skeptic could point out that this is exactly the kind of subgroup slicing that you are not supposed to do without pre-registering it, which I don’t think this team did. I agree with the skeptic. Vallejos et al: Another Argentine study. It’s big (250 people in each arm). It’s an RCT. It tries to define a primary outcome (“Primary outcome: the trial ended when the last patient who was included achieved the end of study visit”), but that’s not what “primary outcome” means, and they don’t offer an alternative. Other outcomes: no difference in PCR on days 3 or 12. Hospitalization is nonsignificantly better in the ivermectin group (14 vs. 21, p = 0.2), but death is nonsigificantly better in the placebo group (3 vs. 4, p = 0.7). This isn’t even the kind of nonsignificant that might contribute to an exciting meta-analysis later. This is just a pure null result. I cannot find any problem with this study, and neither can anyone else I checked. This is the biggest RCT we’ve seen so far, so we should take it seriously. TOGETHER Trial: Speaking of big RCTs… This one hasn’t been published yet. There’s a video of a talk about it, but I am not going to watch it, because it is a video, so I am getting information secondhand from eg here. Apparently, it compares 677 people (!) randomized to ivermectin to 678 people randomized to placebo. 86 ivermectin patients ended up in the hospital compared to 95 placebo patients, p-value not significant. This was a really big professional trial done by bigshot researchers from a major Canadian university, and the medical establishment is taking it much more seriously than any of these others. When it comes out, it will probably get published in a top journal. When discussing Lopez-Medina, I wrote: When people say things like “sure, a lot of small studies show good results for ivermectin, but the bigger and more professional trials don’t”, this is one of the two big professional trials they’re talking about. This is the other one. Not coincidentally, it’s also the other trial that ivmmeta.com has a warning letter underneath telling you to disregard. Their main concern is that instead of truly randomizing patients to ivermectin vs. placebo, they did a time-dependent randomization that meant during some weeks more patients were getting one or the other. This is a problem because the trial takes place in Brazil, where different variants were more common at different times. Here’s their image: On the one hand, I have immense contempt for ivmmeta for letting all those other awful studies pass and then pulling out all the stops to try to nitpick this one. I have no idea if their proposed randomization failure really happened. And no doubt the reason they’re even able to investigate this is that this study is really careful and transparent - most of them don’t tell you anything about their randomization method. I would be shocked if other studies don’t have all these problems and worse. On the other hand, the point isn’t to be fair, it’s to be right. And this is a potential confounder. Not a huge one. But a potential one. I guess all we can do is try to bound the damage. Even if the confounding is 100% real and bad, there’s no way to make this study consistent with the crazy super-pro-ivermectin results of studies like Espitia-Hernandez and Aref. And even if we deny any confounding, we see the same slight pro-ivermectin trend - 86 hospitalizations vs. 95 - that we’ve seen in so many other studies. Nothing is going to make me believe that this isn’t in the top 33% of studies we’ve been looking at, so let’s add it as grist for the meta-analysis (though maybe not quite as much grist as its vast size indicates) and move on, angrily. Buonfrate et al: An Italian RCT. Patients were randomized into low-dose ivermectin (32), placebo (29), or high-dose ivermectin (32). Primary outcome was viral load on day 7. There was no significant difference (average of 2 in ivermectin groups, 2.2 in placebo group). They admit that they failed to reach the planned sample size, but did a calculation to show that even if they had, the trial could not have returned a positive result. Clinically, an average of 2 patients were hospitalized in each of the ivermectin arms, compared to 0 in the placebo arm - which bucks our previously-very-constant pro-ivermectin trend. Mayer et al: Not an RCT. Patients in an Argentine province were offered the opportunity to try ivermectin; 3266 said yes and become the experimental group, 17966 said no and became the control group. There were many obvious differences between the groups, but they all seemed to handicap ivermectin. There was a nonsignificant trend toward less hospitalization and significantly less mortality (1.5% vs. 2.1%, p = 0.03). While looking into this study, I learned the term “immortal time bias”. This means a period in between selection for the study and the beginning of study recording where patient outcomes are not counted. I think the problem here is that if you signed up for the system on Day X, and if you got sick before they could give you ivermectin, you were in the control group. See this Twitter thread, I have not confirmed everything he says. This only hardens my resolve to stay away from non-RCTs. Borody et al: Our last paper! …is it a paper? I can’t find it published anywhere. It mostly seems to be on news sites. Doesn’t look peer-reviewed. And it starts with “Note that views expressed in this opinion article are the writer’s personal views”. Whatever. 600 Australians were treated with ivermectin, doxycycline, and zinc. The article compares this to an “equivalent control group” made of “contemporary infected subjects in Australia obtained from published Covid Tracking Data”; this is not how you control group, @#!% you. Then it gets excited about the fact that most patients had better symptoms at the end of the ten-day study period than the beginning (untreated COVID resolves in about ten days). Why are these people wasting my time with this? Let’s move on. The Analysis If we remove all fraudulent and methodologically unsound studies from the table above, we end up with this: Gideon Meyerowitz-Katz, who investigated many of the studies above for fraud, tried a similar exercise. I learned about his halfway through, couldn’t help seeing it briefly, but tried to avoid remembering it or using it when generating mine (also, I did take the result of his fraud investigations into account), so they should be considered not quite independent efforts. His looks like this: He nixed Chowdhury, Babaloba, Ghauri, Faisal, and Aref, but kept Szenta Fonseca, Biber (?), and Mayer. There was correlation of 0.45, which I guess is okay. I asked him about his decision-making, and he listed a combination of serious statistical errors and small red flags adding up. I was pretty uncomfortable with most of these studies myself, so I will err on the side of severity, and remove all studies that either I or Meyerowitz-Katz disliked. We end up with the following short list: We’ve gone from 29 studies to 11, getting rid of 18 along the way. For the record, we eliminated 2/19 for fraud, 1/19 for severe preregistration violations, 10 for methodological problems, and 6 because Meyerowitz-Katz was suspicious of them. …but honestly this table still looks pretty good for ivermectin, doesn’t it? Still lots of big green boxes. Meyerowitz-Katz accuses ivmmeta of cherry-picking what statistic to use for their forest plot. That is, if a study measures ten outcomes, they sometimes take the most pro-ivermectin outcome. Ivmmeta.com counters that they used a consistent and reasonable (if complicated) process for choosing their outcome of focus, that being: If studies report multiple kinds of effects then the most serious outcome is used in calculations for that study. For example, if effects for mortality and cases are both reported, the effect for mortality is used, this may be different to the effect that a study focused on. If symptomatic results are reported at multiple times, we used the latest time, for example if mortality results are provided at 14 days and 28 days, the results at 28 days are used. Mortality alone is preferred over combined outcomes. Outcomes with zero events in both arms were not used (the next most serious outcome is used — no studies were excluded). For example, in low-risk populations with no mortality, a reduction in mortality with treatment is not possible, however a reduction in hospitalization, for example, is still valuable. Clinical outcome is considered more important than PCR testing status. When basically all patients recover in both treatment and control groups, preference for viral clearance and recovery is given to results mid-recovery where available (after most or all patients have recovered there is no room for an effective treatment to do better). If only individual symptom data is available, the most serious symptom has priority, for example difficulty breathing or low SpO2 is more important than cough. I’m having trouble judging this, partly because Meyerowitz-Katz says ivmmeta has corrected some earlier mistakes, and partly because there really is some reasonable debate over how to judge studies with lots of complicated endpoints. By this point I had completely forgotten what ivmmeta did, so I independently coded all 11 remaining studies following something in between my best understanding of their procedure and what I considered common sense. The only exception was that when the most severe outcome was measured in something other than patients (ie average number of virus copies per patient), I defaulted to one that was measured in patients instead, to keep everything with the same denominator. My results mostly matched ivmmeta’s, with one or two exceptions that I think are within the scope of argument or related to my minor deviations from their protocol. Placebo vs. ivermectin groups sometimes differed in size, which I’ve adjusted for and rounded off. Probably I’m forgetting some reason I can’t just do simple summary statistics to this, but whatever. It is p = 0.15, not significant. This is maybe unfair, because there aren’t a lot of deaths in the sample, so by focusing on death rather than more common outcomes we’re pointlessly throwing away sample size. What happens if I unprincipledly pick whatever I think the most reasonable outcome to use from each study is? I’ve chosen “most reasonable” as a balance between “is the most severe” and “has a lot of data points”: Now it’s p = 0.04, seemingly significant, but I had to make some unprincipled decisions to get there. I don’t think I specifically replaced negative findings with positive ones, but I can’t prove that even to myself, let alone to you. [UPDATE 5/31/22: A reader writes in to tell me that the t-test I used above is overly simplistic. A Dersimonian-Laird test is more appropriate for meta-analysis, and would have given 0.03 and 0.005 on the first and second analysis, where I got 0.15 and 0.04. This significantly strengthens the apparent benefit of ivermectin from ‘debatable’ to ‘clear’. I discuss some reasons below why I am not convinced by this apparent benefit.] (how come I’m finding a bunch of things on the edge of significance, but the original ivmmeta site found a lot of extremely significant things? Because they combined ratios, such that “one death in placebo, zero in ivermectin” looked like a nigh-infinite benefit for ivermectin, whereas I’m combining raw numbers. Possibly my way is statistically illegitimate for some reason, but I’m just trying to get a rough estimate of how convinced to be) So we are stuck somewhere between “nonsignificant trend in favor” and “maybe-significant trend in favor, after throwing out some best practices”. This is normally where I would compare my results to those of other meta-analyses made by real professionals. But when I look at them, they all include studies later found to be fake, like Elgazzar, and unsurprisingly come up with wildly positive conclusions. There are about six in this category. One of them later revised their results to exclude Elgazzar and still found strong efficacy for ivermectin, but they still included Niaee and some other dubious studies. The only meta-analysis that doesn’t make these mistakes is Popp (a Cochrane review), which is from before Elgazzar was found to be fraudulent, but coincidentally excludes it for other reasons. It also excludes a lot of good studies like Mahmud and Ravakirti because they give patients other things like HCQ and azithromycin - I chose to include them, because I don’t think they either work or have especially bad side effects, so they’re basically placebo - but Cochrane is always harsh like this. They end up with a point estimate where ivermectin cuts mortality by 40% - but say the confidence intervals are too wide to draw any conclusion. I think this basically agrees with my analyses above - the trends really are in ivermectin’s favor, but once you eliminate all the questionable studies there are too few studies left to have enough statistical power to reach significance. Except that everyone is still focusing on deaths and hospitalizations just because they’re flashy. Mahmud et al, which everyone agrees is a great study, found that ivermectin decreased days until clinical recovery, p = 0.003? So what do you do? This is one of the toughest questions in medicine. It comes up again and again. You have some drug. You read some studies. Again and again, more people are surviving (or avoiding complications) when they get the drug. It’s a pattern strong enough to common-sensically notice. But there isn’t an undeniable, unbreachable fortress of evidence. The drug is really safe and doesn’t have a lot of side effects. So do you give it to your patients? Do you take it yourself? Here this question is especially tough, because, uh, if you say anything in favor of ivermectin you will be cast out of civilization and thrown into the circle of social hell reserved for Klan members and 1/6 insurrectionists. All the health officials in the world will shout “horse dewormer!” at you and compare you to Josef Mengele. But good doctors aren’t supposed to care about such things. Your only goal is to save your patient. Nothing else matters. I am telling you that Mahmud et al is a good study and it got p = 0.003 in favor of ivermectin. You can take the blue pill, and stay a decent respectable member of society. Or you can take the horse dewormer pill, and see where you end up. In a second, I’ll tell you my answer. But you won’t always have me to answer questions like this, and it might be morally edifying to observe your thought process in situations like this. So take a second, and meet me on the other side of the next section heading. … … … … … The Synthesis Hopefully you learned something interesting about yourself there. But my answer is: worms! As several doctors and researchers have pointed out (h/t especially Avi Bitterman and David Boulware), the most impressive studies come from places that are teeming with worms. Mahmud from Bangladesh, Ravakirti from East India, Lopez-Medina from Colombia, etc. Here’s the prevalence of roundworm infections by country (source). But alongside roundworms, there are threadworms, hookworms, blood flukes, liver flukes, nematodes, trematodes, all sorts of worms. Add them all up and somewhere between half and a quarter of people in the developing world have at least one parasitic worm in their body. Being full of worms may impact your ability to fight coronavirus. Gluchowska et al write: Helminth [ie worm] infections are among the most common infectious diseases. Bradbury et al. highlight the possible negative interactions between helminth infection and COVID-19 severity in helminth-endemic regions and note that alterations in the gut microbiome associated with helminth infection appear to have systemic immunomodulatory effects. It has also been proposed that helminth co-infection may increase the morbidity and mortality of COVID-19, because the immune system cannot efficiently respond to the virus; in addition, vaccines will be less effective for these patients, but treatment and prevention of helminth infections might reduce the negative effect of COVID-19. During millennia of parasite-host coevolution helminths evolved mechanisms suppressing the host immune responses, which may mitigate vaccine efficacy and increase severity of other infectious diseases. Treatment of worm infections might reduce the negative effect of COVID-19! And ivermectin is a deworming drug! You can see where this is going… The most relevant species of worm here is the roundworm Strongyloides stercoralis. Among the commonest treatments for COVID-19 is corticosteroids, a type of immunosuppresant drug. The types of immune responses it suppresses do more harm than good in coronavirus, so turning them off limits collateral damage and makes patients better on net. But these are also the types of immune responses that control Strongyloides. If you turn them off even very briefly, the worms multiply out of control, you get what’s called “Strongyloides hyperinfection”, and pretty often you die. According to the WHO: The current COVID-19 pandemic serves to highlight the risk of using systemic corticosteroids and, to a lesser extent, other immunosuppressive therapy, in populations with significant risk of underlying strongyloidiasis. Cases of strongyloidiasis hyperinfection in the setting of corticosteroid use as COVID-19 therapy have been described and draw attention to the necessity of addressing the risk of iatrogenic strongyloidiasis hyperinfection syndrome in infected individuals prior to corticosteroid administration. Although this has gained importance in the midst of a pandemic where corticosteroids are one of few therapies shown to improve mortality, its relevance is much broader given that corticosteroids and other immunosuppressive therapies have become increasingly common in treatment of chronic diseases (e.g. asthma or certain rheumatologic conditions). So you need to “address the risk” of strongyloides infection during COVID treatment in roundworm-endemic areas. And how might you address this, WHO? Treatment of chronic strongyloidiasis with ivermectin 200 µg/kg per day orally x 1-2 days is considered safe with potential contraindications including possible Loa loa infection (endemic in West and Central Africa), pregnancy, and weight <15kg. Given ivermectin’s safety profile, the United States has utilized presumptive treatment with ivermectin for strongyloidiasis in refugees resettling from endemic areas, and both Canada and the European Centre for Disease Prevention and Control have issued guidance on presumptive treatment to avoid hyperinfection in at risk populations. Screening and treatment, or where not available, addition of ivermectin to mass drug administration programs should be studied and considered. This is serious and common enough that, if you’re not going to screen for it, it might be worth “add[ing] ivermectin to mass drug administration programs” in affected areas! Dr. Avi Bitterman carries the hypothesis to the finish line: First two images are with all relevant studies; second two are a sensitivity analysis that removes some of the most dubious. The good ivermectin trials in areas with low Strongyloides prevalence, like Vallejos in Argentina, are mostly negative. The good ivermectin trials in areas with high Strongyloides prevalence, like Mahmud in Bangladesh, are mostly positive. Worms can’t explain the viral positivity outcomes (ie PCR), but Dr. Bitterman suggests that once you remove low quality trials and worm-related results, the rest looks like simple publication bias: This is still just a possibility. Maybe I’m over-focusing too hard on a couple positive results and this will all turn out to be nothing. Or who knows, maybe ivermectin does work against COVID a little - although it would have to be very little, fading to not at all in temperate worm-free countries. But this theory feels right to me. It feels right to me because it’s the most troll-ish possible solution. Everybody was wrong! The people who called it a miracle drug against COVID were wrong. The people who dismissed all the studies because they F@#king Love Science were wrong. Ivmmeta.com was wrong. Gideon Meyerowitz-Katz was…well, he was right, actually, I got the worm-related meta-analysis graphic above from his Twitter timeline. Still, an excellent troll. Also, the best part is that I ignorantly asked, in my description of Mahmud et al above: And it was! It was a fluke! A literal, physical, fluke! For my whole life, God has been placing terrible puns in my path to irritate me, and this would be the worst one ever! So it has to be true! The Scientific Takeaway About ten years ago, when the replication crisis started, we learned a certain set of tools for examining studies. Check for selection bias. Distrust “adjusting for confounders”. Check for p-hacking and forking paths. Make teams preregister their analyses. Do forest plots to find publication bias. Stop accepting p-values of 0.049. Wait for replications. Trust reviews and meta-analyses, instead of individual small studies. These were good tools. Having them was infinitely better than not having them. But even in 2014, I was writing about how many bad studies seemed to slip through the cracks even when we pushed this toolbox to its limits. We needed new tools. I think the methods that Meyerowitz-Katz, Sheldrake, Heathers, Brown, Lawrence and others brought to the limelight this year are some of the new tools we were waiting for. Part of this new toolset is to check for fraud. About 10 - 15% of the seemingly-good studies on ivermectin ended up extremely suspicious for fraud. Elgazzar, Carvallo, Niaee, Cadegiani, Samaha. There are ways to check for this even when you don’t have the raw data. Like: The Carlisle-Stouffer-Fisher method: Check some large group of comparisons, usually the Table 1 of an RCT where they compare the demographic characteristics of the control and experimental groups, for reasonable p-values. Real data will have p-values all over the map; one in every ten comparisons will have a p-value of 0.1 or less. Fakers seem bad at this and usually give everything a nice safe p-value like 0.8 or 0.9.
Inline links: Elgazzar et al:, here, Chowdury et al, Espitia-Hernandez et al:, deviated from its preregistration, https://substackcdn.com/image/fetch/$s_!nJOk!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2Fda0f378f-c7e9-446c-909b-b870b062fd39_589x444.png, Carvallo et al:, another Carvallo paper was retracted, Mahmud et al:, https://substackcdn.com/image/fetch/$s_!ST60!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F1ff4783b-1473-4413-9230-8b15a5549208_500x469.gif, Szenta Fonseca et al:, Cadegiani et al:, a BMJ article, a deeper dive, https://substackcdn.com/image/fetch/$s_!ARca!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F7fe429e5-dba6-4b59-b46f-a2345b6acaf4_1080x720.jpeg, Ahmed et al:, Chaccour et al:, Ghauri et al:, Babaloba et al:, https://substackcdn.com/image/fetch/$s_!f598!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F0238280a-236e-47f5-9db6-7c35c07c5fc2_520x393.jpeg, https://substackcdn.com/image/fetch/$s_!SRpb!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2Fb5271fbd-b82a-4e34-9787-8b3aa6e8d2f6_595x522.png, https://substackcdn.com/image/fetch/$s_!cKHm!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2Ff9be5d50-858b-4c3a-bef7-a312df762eda_638x549.png, Ravakirti et al:, Bukhari et al:, Mohan et al:, Biber et al:, the preregistration, Elalfy et al:, https://substackcdn.com/image/fetch/$s_!B_IH!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F4d3559ee-a058-44cc-9b38-09b78a0f5035_1352x1070.png, https://substackcdn.com/image/fetch/$s_!9mI_!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2Fbffceed7-c84a-45c1-abfe-1fb2706dc383_483x674.png, Lopez-Medina et al:, Roy et al:, Chahla et al:, Mourya et al:, Loue et al:, Table 1, Merino et al:, never works, Faisal et al:, Aref et al:, https://substackcdn.com/image/fetch/$s_!-FoK!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2Ff6de79b6-091b-4c13-b7be-715c9bb194a7_986x810.jpeg, Krolewiecki et al:, Vallejos et al:, TOGETHER Trial:, here, https://substackcdn.com/image/fetch/$s_!7X0m!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F1f65fd44-58b9-4489-a934-02a5a7330499_706x768.png, Buonfrate et al:, Mayer et al:, immortal time bias, this Twitter thread, Borody et al:, https://substackcdn.com/image/fetch/$s_!Wpjs!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F2d8a451b-b1fc-44e5-ae67-b1506e491762_914x657.png, https://substackcdn.com/image/fetch/$s_!DOjA!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F17d5827a-38da-4a99-beb3-c3018df5c633_920x604.png, https://substackcdn.com/image/fetch/$s_!GX1n!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2Fc692fec8-a450-4579-b337-c72bec060970_912x298.png, https://substackcdn.com/image/fetch/$s_!YcH4!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2Ff36db98e-e653-44da-906c-20312b1689a3_468x205.png, https://substackcdn.com/image/fetch/$s_!jbcL!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2Fd189a844-daf2-4199-bb2e-830d4fc64415_468x206.png, later revised their results to exclude Elgazzar, Popp, https://substackcdn.com/image/fetch/$s_!2B6r!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F505c5ac4-3fe8-47a4-8505-dab80601b44d_416x198.png, Avi Bitterman, David Boulware, https://substackcdn.com/image/fetch/$s_!JWWh!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2Fac9e4f34-f9cc-40f2-9d83-da4e7178fad7_772x330.png, source, Gluchowska et al, the WHO, carries, https://substackcdn.com/image/fetch/$s_!xExE!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F5da21781-249c-4e59-b616-9f23d83cc044_2048x1184.jpeg, https://substackcdn.com/image/fetch/$s_!4SMr!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2Fdcd6e4b2-37f7-4602-93d5-2581c3b27a60_700x432.png, https://substackcdn.com/image/fetch/$s_!-6n2!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F7fd6e8f4-093e-4e02-bce7-363615146c9c_2228x1346.jpeg, https://substackcdn.com/image/fetch/$s_!CPZs!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2Fb0425847-198a-4bd3-a63b-149f15d147ba_700x432.png, https://substackcdn.com/image/fetch/$s_!H3rK!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F9972491b-25b0-4c06-8aca-86fce102ae63_666x147.png, even in 2014, The Carlisle-Stouffer-Fisher method
PCs1 mentions across 1 issues

PCs is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between April 04, 2022 and April 04, 2022. The archive places it in contexts such as "selling PCs and Windows CDs". It most often appears alongside 2013, Agricultural Revolution, AI.

Reference entry
PCs
Mention count
1
Issue count
1
First seen
April 04, 2022
Last seen
April 04, 2022
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Source context
Yudkowsky Contra Christiano On AI Takeoff Speeds
April 04, 2022 · Original source
Consider cryptocurrency as an example. In 2010, cryptocurrency was small and hard to use. Its profits might have been growing quickly in relative terms, but slowly in absolute terms. But by 2020, it had become the next big thing. People were inventing new cryptocurrencies every day, technical challenges were falling one after another, lots of people were getting rich. And by 2030, presumably cryptocurrency will be where eg personal computers are now - still a big business, but most of the interesting work has been done, it’s growing at a boring normal growth rate, and improvements are rare and marginal.
Now imagine a graph of total tech industry profits over time. Without having seen this graph, I imagine relatively consistent growth. In the 1990s, the growth was mostly from selling PCs and Windows CDs, which were on the super-hot growth parts of their sigmoid. By the 2000s, those had matured and flattened out, but new paradigms (smartphones, online retail) were on the super-hot growth parts of their sigmoids. By the late 2010s, those had matured too, but newer paradigms (cryptocurrency, electric cars) were on the super-hot growth parts of their sigmoids. If we want to know what the next decade will bring, we should look for paradigms that are still in the early-slow-growth stage, maybe quantum computers. The idea is: each individual paradigm has a sigmoid that slows and peters out, but the tech industry as a whole generates new sigmoids and maintains its usual growth rate.
PCSK91 mentions across 1 issues

PCSK9 is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between July 01, 2025 and July 01, 2025. The archive places it in contexts such as "a specific gene, known as PCSK9, in the liver"; "as PCSK9, in the liver". It most often appears alongside Afrobarometer, AGI, AI 2027.

Reference entry
PCSK9
Mention count
1
Issue count
1
First seen
July 01, 2025
Last seen
July 01, 2025
Outbound links
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Source context
Links For July 2025
July 01, 2025 · Original source
52: New treatment may be able to permanently decrease cholesterol 69% after a single shot. “Instead of managing cholesterol over time like statins, VERVE-102 aims to provide a one-time fix by ‘switching off’ a specific gene, known as PCSK9, in the liver.”
Inline links: New treatment may be able to permanently decrease cholesterol 69% after a single shot
PDAPP mouse1 mentions across 1 issues

PDAPP mouse is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between July 11, 2025 and July 11, 2025. The archive places it in contexts such as "That’s what made the PDAPP (Platelet-Derived growth factor (PDGF-β) Amyloid Precursor Protein) mouse a remarkable achievement"; "the PDAPP mouse delivers on the amyloid cascade hypothesis"; ""why do we want to see these results?.. The PDAPP mouse needs to replicate the key features of Alzheimer’s disease"". It most often appears alongside aducanumab, Alzheimer’s, Alzheimer’s Disease.

Reference entry
PDAPP mouse
Mention count
1
Issue count
1
First seen
July 11, 2025
Last seen
July 11, 2025
Outbound links
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Source context
Your Review: Of Mice, Mechanisms, and Dementia
July 11, 2025 · Original source
Let’s pause to acknowledge the obsessive craft of the skilled bench scientist. The PDAPP Mouse Arrives Once injected, the embryos were surgically transferred into surrogate mothers, then scientists waited anxiously for 18–21 days to see if any pups survived. When they did, DNA was extracted, and tests were run to see which, if any, carried the transgene. Success rates? Single-digit percentages. For every founder animal that carried the transgene, there were at least an order of magnitude more failed attempts.
Sufficiency [2]: If Alzheimer’s-like pathology can result from ramping up human APP expression alone, then the PDAPP mouse is a quasi-test of sufficiency. If this mouse model develops plaques, tangles, synaptic loss, neurodegeneration, and cognitive impairment, then Aβ might be sufficient to initiate the disease process.
Critical Controls: Including controls in your experiments helps to demonstrate that your predicted effect isn’t arising for some other reason. Here are some controls you’d like to see in the PDAPP mouse study if you’re going to be convinced of the amyloid cascade hypothesis:
PE coatings1 mentions across 1 issues

PE coatings is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between June 18, 2025 and June 18, 2025. The archive places it in contexts such as "We have continued testing these PE coatings, alongside PEG coatings, on our membranes". It most often appears alongside 1DaySooner, Aatu Koskensilta, acanthamoeba keratitis.

Reference entry
PE coatings
Mention count
1
Issue count
1
First seen
June 18, 2025
Last seen
June 18, 2025
Outbound links
Issue trail
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Source context
ACX Grants 1-3 Year Updates
June 18, 2025 · Original source
Minnesota and Virginia also have legislation to enable cities to implement land value taxes. We are monitoring these efforts. There are a few other cities we are operating in. We have helped another organization prepare for a meeting in Tennessee by doing impact analysis of land value taxes in the city. We have presented to city officials in the City of South Bend who have expressed support for land value taxes. Finally, we are in conversation with a State Senator in Colorado who is a champion of land value taxes. Meanwhile, we have soft launched and developed the OpenAVMKit, which uses a unified schema to do assessment accuracy reports and automated valuation methods for any property tax data given. Valuation of land is the key binding constraint to successful implementation of land value taxes. We plan to be the leaders in this space with strong benchmarking capabilities and a repo that can enable the open-source community to make the best automated valuation methods. Along with these efforts, we have expanded the movement. We have posted to the Progress and Poverty Substack growing the subscriber base to around 5,000 subscribers. We have spoken to over 25 local advocates interested in working on land value taxes in their local communities. Yet, there is a long way to go. We need to start earning income through technical assistance contracts as our grant funding expires. We need to continue pushing for a state to implement, and we need to be prepared to tell the success story for when they do. 65: EN’s Work On Bacteriophage Therapy Our project is aimed at pioneering phage therapy in Nigeria, where limited resources/infrastructure have historically held back research in this field. Starting from the ground up, we are establishing the foundational systems needed to support a robust phage research ecosystem. So far, we’ve isolated 34 bacteriophages targeting Pseudomonas aeruginosa, an essential step toward building a comprehensive phage bank. This began with collecting a wide range of clinical Pseudomonas isolates, which we are now characterizing alongside the phages through genome sequencing and phenotypic assays including studies on phage stability across pH, temperature, and salinity ranges. Our long-term goal is to develop a phage-based hydrogel for treating diabetic wounds. On the regulatory front, we have secured approval from the Attorney General to register our nonprofit organization, the Centre for Phage Biology and Therapeutics. Additionally, we’re expanding into vaccine development; following a research stay in Prof. Roderick's lab at the University of Waterloo, we have initiated the design of a phage-based universal Salmonella vaccine aimed at covering all major serotypes—an urgent need underscored by Africa’s reliance on external vaccine sources during the COVID-19 pandemic. I have signed an MTA agreement with Roderick to use his phage-based vaccine platform patents to enable us to design vaccines against any common disease affecting us. This is only the beginning, but we are proud to be laying the scientific and institutional groundwork for homegrown phage innovation in Africa. Emergent Ventures funded EN before we did and deserves a lot of credit here also. 66: Create An Artificial Kidney For an implantable artificial kidney, the first essential component is a hemofilter designed to emulate the glomerulus. Critical requirements for this hemofilter include high permeability (to maximize flow for a given area), selectivity (specifically, the retention of albumin), and robust blood compatibility (ensuring sustained function over time). Our initial strategy focused on using negative surface charge to reduce fouling. I began by testing polyelectrolyte (PE) coatings on 24nm pore membranes featuring a negative terminal charge, similar to the glomerular barrier. These initial static tests, assessing platelet adsorption in whole blood, yielded positive outcomes for some polyelectrolytes, indicating potentially desirable blood compatibility. However, static test setups are not truly representative of dynamic in-vitro conditions and don't provide data on key parameters like permeability, fouling progression, or changes in membrane selectivity. To address these limitations, I designed and built a blood filtration setup. This system sustains human whole blood in circulation for 20 minutes, allowing us to analyze all the aforementioned parameters, as well as platelet activation markers. This has resulted in a fairly high-throughput system for evaluating any surface coating. I'm pleased to report this setup has been accepted for presentation at this year's European Society for Artificial Organs (ESAIO) conference. I am also currently working on a full manuscript, as I believe this system offers a viable way to partially replace animal experiments in our early-stage research, requiring only 1.2ml of human blood per run. Working with a PhD student (hired to support both this research and work on membrane substrates), we have continued testing these PE coatings, alongside PEG coatings, on our membranes. Here, we're finding that optimization of the coating layer is crucial. With the current PE coatings, we observe a permeability drop of about an order of magnitude compared to the base membrane, making them unsuitable for an implantable device in their present form. This is likely due to the specific nature of the initial PE layer, which we can modify. We also suspect there may be ingress of PE into the pores, meaning we're not achieving just a surface coating (our goal), but rather a very thick coating, which would explain the flux loss. Optimizing the coating process to control penetration depth is now a primary focus of my ongoing work. I am currently aiming for a flux of 20ul/min (as this is cap introduced by the protein gel layer anyway) but for it to be at this 'steady state' permeability without drop in permeability. I am also imaging the membranes after contact with SEM to see if there is indeed any platelet adsorption etc. Tugrul has the dubious honor of maybe being "the only person to climb a 4000m peak with severe kidney failure". To raise money and awareness for his artificial kidney project, he is running Climb Against Time, where he will climb 41 mountains over 4000m (13000 ft) this summer. He is looking for donors and climbing partners. 67: Add Tardigrade Genes To Human Cells The goal of this one was to make hybrid cells that are more resilient for research and certain medical applications. They report: The grant was to synthesize vectors for the expression of humanized tardigrade proteins that can be targeted to different areas of the cell. All the vectors were designed, generated, and transposed into human cells. The proteins all localize successfully (e.g. they match the designed target), with one exception (we are still working on validating it). We've done some stress testing with the trangenic cells, but haven't reached firm conclusions yet. We've further generated some multigene designs but have not yet transposed them into cells, but should shortly. We're hoping to submit a manuscript on the first round later this year. 68: Teach Forecasting To EU Policy-Makers The original project didn't work out, but our grantee (who still prefers to remain anonymous) is now working with an EU think tank pursuing the same agenda, and has been teaching forecasting workshops to policy-makers for the past two months. 69: Platform For Single-Cell Imaging They ended up unable to accept this grant and returned the money. 70: Open Source Polygenic Predictor For EA/IQ They have an update here. They think they have a predictor that can explain 12% of variance in intelligence, and they’re working on validating it and creating an easy-to-use website. 71: Improve Flu Vaccines The grant mainly funded agent based modelling to demonstrate the benefit of pre-existing immunity to pandemic influenza if and when a future pandemic occurs (academic publication will result). The original proposal was to attempt to influence the WHO influenza strain selection process. After attending WHO meetings and a global influenza conference, I believe this is not feasible. Stakeholder feedback was the potential short term negative effect on vaccine hesitancy is believed to outweigh the less tangible future benefit. Given the conservative nature of decision makers, pandemic vaccines are likely to remain research only. There are still green shoots of research into pandemic preparedness/prevention that I am continuing to work on. I'm working under the "Australians for Pandemic Prevention" brand of Good Ancestors, another group that ACX funded in 2024. 72: Scenario Analysis For Developing World Agricultural Programs In addition to the research and analysis funded by the grant, I’ve learned to code with LLMs and have built an MVP of the project. The app is being considered for further development by staff at a large international organization. 73: Further C’s Political Career C’s political career is going well, but he continues to think it wouldn’t be strategic to give more information publicly at this time. Lessons Learned I'm most impressed with our lobbying/advocacy organizations. In particular, Good Ancestors has gotten the Australian government to sign onto an international AI safety declaration, partner with various x-risk-related organizations, and (possibly) extend charity tax deductions to some EA causes that previously didn't have it - I think this on its own goes a substantial way to paying back the cost of all ACX Grants. Coalition to Modify NOTA has a kidney donation bill in front of Congress that the (very illiquid) prediction markets give a 45% chance of passing; if it works, it could save thousands of lives. The Georgists are partly responsible for bills making land value taxes slightly easier to implement in a handful of states. Good Science Project seems to have significantly improved science. Are lobbying organizations a better bet than other types of nonprofit (within the constraints of ACX Grants)? I'm not sure. It could just be that lobbyists are (naturally) better at playing themselves up and sounding successful than (for example) scientists, or that politicians are good at people-pleasing and make people feel heard and encouraged in a way that might not change overall policy later. Also, I recently talked to some grantmakers who funded a lobbying organization that superficially seems excellent, but they expressed concern it was net negative (!) by taking away oxygen and spotlight from potentially more effective orgs. So I am encouraged but wary. Animal welfare organizations were another standout success. Again, I don't know how to think about this - while I think our grantees were exceptional, there's also an issue where the scale of animal welfare challenges is so great, and work on them so neglected, that lots of organizations can save a million chickens here, or a million fish there, without particularly making a splash. On the one hand, this is exactly what effective altruism should be doing - exploring grants that are very high in linear utility even if they don't feel satisfying. On the other, they're unsatisfying - and also hard to assess retroactively. How many chickens should a good animal welfare grant save? Any realistic number will both be overwhelmingly large in absolute terms and far too small in relative terms. I'm most ambivalent about our science grants. Many of them say they are successful and can point to published papers which explain the science they did. But it's hard to judge whether anything useful has changed based on the science getting done. I know it's important to fund basic research and not just last-mile technology startups, but it's hard for a mini-grants program like this one to evaluate these kinds of abstract interventions. One disappointing result was that grants to legibly-credentialled people operating in high-status ways usually did better than betting on small scrappy startups (whether companies or nonprofits). For example, Innovate Animal Ag was in many ways overdetermined as a grantee - former Yale grad and Google engineer founder, profiled in NYT, already funded by Open Philanthropy - and they in fact did amazing work. On the other hand, there were a lot of promising ACX community members with interesting ideas who were going to turn them into startups any day now, but who ended up kind of floundering (although this also describes Manifold, one of our standout successes). One thing I still don't understand is that Innovate Animal Ag seemed to genuinely need more funding despite being legibly great and high status - does this screen off a theoretical objection that they don't provide ACX Grants with as much counterfactual impact? Am I really just mad that it would be boring to give too many grants to obviously-good things that even moron could spot as promising? Someone (I think it might be Paul Graham) once said that they were always surprised how quickly destined-to-be-successful startup founders responded to emails - sometimes within a single-digit number of minutes regardless of time of day. I used to think of this as mysterious - some sort of psychological trait? Working with these grants has made me think of it as just a straightforward fact of life: some people operate an order of magnitude faster than others. The Manifold team created something like five different novel institutions in the amount of time it's taken some other grantees to figure out a business plan; I particularly remember one time when I needed something, sent out a request to talk about it with two or three different teams, and the Manifold team had fully created the thing and were pestering me to launch a trial version before some of the other people had even gotten back to me. I take no pleasure in reporting this - I sometimes take a week or two to answer emails, and all of the predictions about my personality that this implies would be correct - but it's increasingly something that I look for and respect. A lot of the most successful grants succeeded quickly, or at least were quick to get on a promising track. Since everything takes ten times longer than people expect, only someone who moves ten times faster than people expect can get things done in a reasonable amount of time. In almost every case where I thought to myself “this is a cool idea, but I don’t know how it’s going to really pay off, as opposed to reaching a cool intermediate accomplishment and then stagnating”, this was a correct criticism, and I should have taken it more seriously. But I can’t rule out that these were good in vague and hard-to-measure ways that I should take more seriously. This one is really self-serving, but in general when people were good communicators (or even bloggers) and wowed me with the writing-composition of their application, they turned out to be a good bet. And when people were hard to understand and annoying to communicate with, even if their ideas seemed good, they were less likely to pan out. Overall Thoughts The total cost of ACX Grants, both rounds, was about $3 million. Do these outcomes represent a successful use of that amount of money? Very naively, startups originating from ACX Grants have about $50 million in value1. If ACX Grants is equivalent to a pre-seed funder, and pre-seed funders usually get ~5%, then if we were VCs we would have a portfolio worth $2.5 million. About 1/5 of ACX Grants were attempting to be market-valued startups, so if we assume the charitable portion did about as well as the startup portion, then the charity portion is “worth” $10 million. There’s some reason to expect this is too high, since much of the startup value came from one successful outlier. But there’s another reason to expect this is too low, since we were aiming at charity rather than market cap, and any actual market cap that our grantees got was an unexpected side effect. I’m treating this as a sanity check rather than as a real number. It’s harder to produce Inside View estimates, because so many of the projects either produce vague deliverables (eg a white paper that might guide future action) or intermediate results only (eg getting a government to pass AI safety regulations is good, but can’t be considered an end result unless those regulations prevent the AI apocalypse). Because we tend towards incubating charities and funding research (rather than last-mile causes like buying bednets), achieved measurable deliverables are thin on the ground. But here are things that ACX grantees have already accomplished: Improved the living/slaughter conditions of 30 million fish.
Inline links: Progress and Poverty Substack, Climb Against Time, here, 1
peace1 mentions across 1 issues

peace is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between July 30, 2024 and July 30, 2024. The archive places it in contexts such as "slave morality, with its concern for charity, peace, and equality". It most often appears alongside /r/iamverysmart, 4chan, Achilles.

Reference entry
peace
Mention count
1
Issue count
1
First seen
July 30, 2024
Last seen
July 30, 2024
Outbound links
Issue trail
Related pages
Source context
Matt Yglesias Considered As The Nietzschean Superman
July 30, 2024 · Original source
But (asks Bentham’s Bulldog) why do we need this guy? Isn’t slave morality, with its concern for charity, peace, and equality - simply correct? Isn’t master morality - with its barbarian warlords bragging about how their golden palaces make them better than peasants - just wrong?
It’s Progressive-era propaganda about the superiority of the American North over the South, but I find it most interesting for its list of virtues. It starts with Liberty, then moves on to Free Speech, Intelligence, Obedience To Law, Knowledge, Equal Rights, Free Schools, Contentment, Love Of Country, Philanthropy, Benevolence, Happiness, Patience, Charity, Faith, Hope, Joy, Industry, Sobriety, Morality, Justice, Virtue, Truth, Honor, Peace, Light, and Immortality. I appreciate the Progressive virtues because of how skew they are to most of the ethical systems I encounter. They’re not leftist (Love Of Country? Industry? Morality?) or rightist (Equal Rights? Free Schools?). They’re not Nietzschean master moralist (Philanthropy? Contentment? Benevolence?) or slave moralist (Industry? Knowledge? Honor?). They’re Christian-ish, but not hair-shirts-and-self-flagellation Christian or God-n-guns-megachurch Christian. They’re the kind of Christians who you can kind of tell are going to end up supporting eugenics in a few years. I think I would classify them as a first-form-slave-morality liberalism, whereas most of the liberalism you encounter these days drifted at least a little into the second form. I’m not 100% on Team Early 20th Century Progressive, but they give me hope that there are weird-yet-coherent groupings of virtues we haven’t even imagined. I feel the same way about some old Soviet posters: These are obviously left-wing, in the sense that they’re literal Communist propaganda. But to the modern eye there’s something off about them, something that makes you want to call them right-wing or even fascist. They’re bold and optimistic. Even though the commissars who commissioned them probably rejected some traditional or capitalist conception of virtue, they still firmly insist that there’s something sort of like virtue or power which is attainable and good. I think these are first-form posters, and that most modern leftism is second-form. I think if you had to group barbarian warlords, Puritans, Soviet communists, and modern leftists on a Nietzschean/geneaological/aesthetic axis, it would go: (Barbarian warlords) | (Puritans, Soviet communists) | (modern leftists) So one very weak compromise - hardly even a compromise, since it predates Nietzsche - is to try to stick with first-form slave morality, in the hopes that most of the problems come from the second. VIII. Ayn Rand “Is Ayn Rand a Nietzschean?”- the greatest thread in the history of forums, locked by a moderator after 12239 pages of heated debate. There’s a real answer here. Rand started out respecting, maybe even loving Nietzsche. She once said that: [Nietzsche’s] Thus Spake Zarathustra is my Bible. I can never commit suicide while I have it. …which maybe reveals more about her psychological situation than I expected from the answer to a “who’s your favorite philosopher” questionnaire. But later on she broke from him. It’s hard to figure out her exact position - she has a bad habit of treating anyone who disagrees with her in any tiny detail as the Antichrist, such that it’s hard to figure out whether she thinks of someone as a 99% fellow traveler or an arch-enemy. Still, there are substantial differences. Nietzsche is more chaotic - he expects the superior man to defy all external rules in favor of his own glorious destiny. But Rand is attached to rules - most of all the epistemic rules of Reason, but also the usual moral tenets like “don’t kill” and “don’t steal”. Nietzsche’s masters take the Ron Swanson approach to justifying their actions: …whereas Rand’s masters are prone to giving twenty-page-long arguments for why whatever they’re doing is the right choice according to Objectively Correct Moral Law. Rand’s approach has lots of advantages. The Nietzschean master, like Andrew Tate, is an awful guy to have around. It’s hard to fit him into a functioning civilization, except maybe an autocracy with him as autocrat. Nietzsche’s pitch is “hey excellent people, you should try to become this guy”, never “hey normal people, you should support my project of creating these guys, out of your own self-interest.” The latter wouldn’t pass the laugh test. Rand’s masters, while still probably very stressful to be around, have been tamed. They follow civilized rules of honesty and nonviolence - not, of course, because they’re too weak to defy them, but because following civilized rules is objectively the coolest thing of all. Instead of competing in battle and leaving a trail of bloody corpses, they compete in Capitalism and leave a trail of high-paying jobs and excellent consumer goods. They’re not doing to serve you - “I should serve the little guy” is slave moralist bulls**t. But, by coincidence, their excellent actions are doing you a service. They might only invent rocket ships to enact their Promethean conquest of nature and prove their own greatness. But you still get to ride in one. Rand also spares more of a thought (or at least an afterthought) for the little guy. Capitalism needs all types - even the company janitor genuinely contributes to whatever glorious accomplishments are going on, and deserves to feel good about themselves. She wants everyone to be the best, most ambitious, and most fighting-for-their-own-aesthetic/moral-vision they can be. But if that means being the company janitor, that’s fine. And if you love rockets and you consummate that love by becoming the janitor for a rocket company, the Objectively Correct Moral Law is 100% on board. I am not a Nietzsche scholar, but I think this is a more productive answer than Nietzsche has for this question. The disadvantage of Rand’s approach compared to Nietzsche’s is that it only works if you believe her proofs about why the Objectively Correct Moral Law is definitely objective and correct - most of which seem to me to be either hand-wavy or balderdash. Otherwise the whole thing breaks down - why is the most masterful thing to be a positive-sum capitalist instead of a negative-sum warlord? Rand really really wants to justify a peaceful, glorious, positive-sum society, to the exact people most capable of benefiting from defecting against it, without bringing in altruism or the common good at any point. It’s an extremely sympathetic goal. But I don’t think she makes it. Still, this is why I’m fond of her. If you really read her books - as opposed to skimming them while subvocalizing “this is that evil woman who loves selfishness” under your breath the whole time - it’s obvious that she believes, with a deep and burning belief, that good things are good. She really really wants to think that you can objectively convince people to support a peaceful, glorious, positive-sum society, without any hint of the psychologically-toxic slave morality that typified the USSR she grew up in. When people react to her books with loathing - without even a hint of fondness - I get suspicious that they’ve gotten so deep into slave morality that thy can’t recognize goodness when it hits them over the head with a sledgehammer. Elsewhere, I wrote: Edward Teach (Sadly, Porn) is famous for making up fake novels to criticize, and it is a little known fact that the "Ayn Rand" character along with all her novels are 100% his work. They operate as a diagnostic test based on his psychodynamic theory of envy. The instrument presents a picture of some exceptional people achieving great things who don't apologize for their greatness, and doesn’t explicitly ask the patient - I mean, reader - for their opinion. If the reader has no strong opinion, or says something like "Good for them, I guess," she passes the test. "I like these people and will use them as a role model" also passes. Some specific criticisms (see below) may also pass. If the reader says "Ah, people who are better than the pathetic sheep around them, just like I'm better than all the pathetic sheep around me!", she . . . still passes the test. That's not what it's testing for! You fail the test if you absolutely freak out about some combination of the Rand characters themselves and the potential existence of arrogant people who identify with the Rand characters. The secret is that it's not a screening test for the kind of people who would get featured on /r/iamverysmart. It's a screening test for the kind of people who would comment on /r/iamverysmart, ie the self-designated Tall Poppy Police, ie the people who build their ego off being the enforcers of the rule that you're not allowed to look better than anyone else. These people's basic mental stance is to hate people who seem too excellent. They don't think of it in these terms. They think of it as calling out arrogance, although if you look too closely you'll find their definition of arrogance covers anyone who seems excellent and but doesn't spend all their time apologizing and abasing themselves and denying it. The brilliance of Teach-Rand is how he-she draws this tendency to the foreground For example, why the whole "Objectivism" thing? Not because value is necessarily completely objective, but because the idea that any value might ever be even partially objective freaks out the Tall Poppy Syndrome people. Mention value at all, and they say you must be trying to secretly smuggle in the assumption that you are more valuable than other people (and therefore you are less valuable than other people, and therefore they are better than you). The same is true of Reason. Mention that Reason exists, and they'll interpret it as a claim that you, the only rational person, are claiming to always be right and infallible. But (they retort) actually nobody knows anything, and the only wise people are the people like them who humbly admit this. (how do you decide what's true without Reason? By bias-based-reasoning - "You say X, but I can imagine a way that would come from a place of believing you're better than other people, therefore, Not-X is true. You say that's a logical fallacy? That must come from a place of believing you're smarter than everyone else and the only person who can use Facts and Logic.") The Teach-Rand test is designed to catch the sort of person who, if someone says that on a right triangle a^2 + b^2 = c^2, responds with "Oh, so you're claiming to be some kind of right triangle expert who's better than the rest of us? You really need to work on that arrogance problem! Super cringe!" Any criticism of the book that doesn't come from this particular place is irrelevant to the test and doesn't count against your grade. (which is good, because the books are bad in a lot of ways. But that's fine - Rorschach blots don't also have to be great art!) Still, I don’t think she’s the superman (superwoman?) who successfully transcends the dichotomy Her philosophy is only as strong as its proofs of Objective Correctness, which I consider weak. Without those, you need some subjective motivation to glue things together - of which altruism is the most popular. But also, don’t we like altruism? When we’re bestriding the Earth like colossi, working on our glorious rocket ships to colonize the universe, isn’t part of what we’re thinking “this is going to revolutionize humankind and make everybody better off?” If you force yourself to reject that motivation, to just repeat “no no no, I’m only doing this because rockets are really big and make cool explosions”, aren’t you cutting out a part of yourself, in exactly the way Nietzschean masters are supposed to try to avoid doing? I find something very compelling about Rand. I think she goes some of the way to answering the Andrew Tate objection to master morality. But she’s a means and not an end. A real superman would have to figure out some way to reintroduce basic human kindness. IX. Matt Yglesias Yglesias’s mantra - “good things are good” - is too perfect and profound to come from anyone other than an esoteric master of Nietzschean philosophy. Good Straussians ignore the title and focus on the subtitle. Nietzsche wrote in the 1890s. There were still real nobles and emperors walking around; communists had not yet started calling capitalism “late capitalism”. Sure, his world was probably some sort of weak compromise between master and slave morality, but it was different from our weak compromise. Our weak compromise was forged through dialogue and warfare with fascism’s novel take on master morality and socialism’s novel take on slave morality. I think of Yglesias - who combines an insistence that good things are good and a proclivity for embiggenment with commitments to democracy, the welfare state, and the poorest among us - as one of its most self-conscious proponents. When I first titled this post, I didn’t know that Richard Hanania had come to the same conclusion and created this face-mash-up of Matt Yglesias and Nietzsche. The compromise goes something like: Everyone is equal before the law, before the metaphorical throne of metaphorical God, and in some poorly defined philosophical sense. This is very important. It’s our headline result. Everything else should be interpreted in light of this central fact.
Inline links: https://substackcdn.com/image/fetch/$s_!6V8D!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F7f1f70cc-b468-4b04-b894-a8b75b3330e5_1024x683.jpeg, https://substackcdn.com/image/fetch/$s_!FF8B!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F0a1ac7aa-d19e-43e8-8462-210325b902be_810x545.png, a real answer here, https://substackcdn.com/image/fetch/$s_!OtNv!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F6ae1aaf2-6cc3-488c-b0a7-5df62eee457b_225x225.jpeg, Elsewhere, Sadly, Porn, /r/iamverysmart, https://substackcdn.com/image/fetch/$s_!MzIr!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Ff03d1a9d-5ffc-45ff-84bc-db3388915bbc_259x390.jpeg, https://substackcdn.com/image/fetch/$s_!hYvV!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fd0f9b152-da12-4525-b062-b4c14d8b8005_383x373.png
These are obviously left-wing, in the sense that they’re literal Communist propaganda. But to the modern eye there’s something off about them, something that makes you want to call them right-wing or even fascist. They’re bold and optimistic. Even though the commissars who commissioned them probably rejected some traditional or capitalist conception of virtue, they still firmly insist that there’s something sort of like virtue or power which is attainable and good. I think these are first-form posters, and that most modern leftism is second-form. I think if you had to group barbarian warlords, Puritans, Soviet communists, and modern leftists on a Nietzschean/geneaological/aesthetic axis, it would go: (Barbarian warlords) | (Puritans, Soviet communists) | (modern leftists) So one very weak compromise - hardly even a compromise, since it predates Nietzsche - is to try to stick with first-form slave morality, in the hopes that most of the problems come from the second. VIII. Ayn Rand “Is Ayn Rand a Nietzschean?”- the greatest thread in the history of forums, locked by a moderator after 12239 pages of heated debate. There’s a real answer here. Rand started out respecting, maybe even loving Nietzsche. She once said that: [Nietzsche’s] Thus Spake Zarathustra is my Bible. I can never commit suicide while I have it. …which maybe reveals more about her psychological situation than I expected from the answer to a “who’s your favorite philosopher” questionnaire. But later on she broke from him. It’s hard to figure out her exact position - she has a bad habit of treating anyone who disagrees with her in any tiny detail as the Antichrist, such that it’s hard to figure out whether she thinks of someone as a 99% fellow traveler or an arch-enemy. Still, there are substantial differences. Nietzsche is more chaotic - he expects the superior man to defy all external rules in favor of his own glorious destiny. But Rand is attached to rules - most of all the epistemic rules of Reason, but also the usual moral tenets like “don’t kill” and “don’t steal”. Nietzsche’s masters take the Ron Swanson approach to justifying their actions: …whereas Rand’s masters are prone to giving twenty-page-long arguments for why whatever they’re doing is the right choice according to Objectively Correct Moral Law. Rand’s approach has lots of advantages. The Nietzschean master, like Andrew Tate, is an awful guy to have around. It’s hard to fit him into a functioning civilization, except maybe an autocracy with him as autocrat. Nietzsche’s pitch is “hey excellent people, you should try to become this guy”, never “hey normal people, you should support my project of creating these guys, out of your own self-interest.” The latter wouldn’t pass the laugh test. Rand’s masters, while still probably very stressful to be around, have been tamed. They follow civilized rules of honesty and nonviolence - not, of course, because they’re too weak to defy them, but because following civilized rules is objectively the coolest thing of all. Instead of competing in battle and leaving a trail of bloody corpses, they compete in Capitalism and leave a trail of high-paying jobs and excellent consumer goods. They’re not doing to serve you - “I should serve the little guy” is slave moralist bulls**t. But, by coincidence, their excellent actions are doing you a service. They might only invent rocket ships to enact their Promethean conquest of nature and prove their own greatness. But you still get to ride in one. Rand also spares more of a thought (or at least an afterthought) for the little guy. Capitalism needs all types - even the company janitor genuinely contributes to whatever glorious accomplishments are going on, and deserves to feel good about themselves. She wants everyone to be the best, most ambitious, and most fighting-for-their-own-aesthetic/moral-vision they can be. But if that means being the company janitor, that’s fine. And if you love rockets and you consummate that love by becoming the janitor for a rocket company, the Objectively Correct Moral Law is 100% on board. I am not a Nietzsche scholar, but I think this is a more productive answer than Nietzsche has for this question. The disadvantage of Rand’s approach compared to Nietzsche’s is that it only works if you believe her proofs about why the Objectively Correct Moral Law is definitely objective and correct - most of which seem to me to be either hand-wavy or balderdash. Otherwise the whole thing breaks down - why is the most masterful thing to be a positive-sum capitalist instead of a negative-sum warlord? Rand really really wants to justify a peaceful, glorious, positive-sum society, to the exact people most capable of benefiting from defecting against it, without bringing in altruism or the common good at any point. It’s an extremely sympathetic goal. But I don’t think she makes it. Still, this is why I’m fond of her. If you really read her books - as opposed to skimming them while subvocalizing “this is that evil woman who loves selfishness” under your breath the whole time - it’s obvious that she believes, with a deep and burning belief, that good things are good. She really really wants to think that you can objectively convince people to support a peaceful, glorious, positive-sum society, without any hint of the psychologically-toxic slave morality that typified the USSR she grew up in. When people react to her books with loathing - without even a hint of fondness - I get suspicious that they’ve gotten so deep into slave morality that thy can’t recognize goodness when it hits them over the head with a sledgehammer. Elsewhere, I wrote: Edward Teach (Sadly, Porn) is famous for making up fake novels to criticize, and it is a little known fact that the "Ayn Rand" character along with all her novels are 100% his work. They operate as a diagnostic test based on his psychodynamic theory of envy. The instrument presents a picture of some exceptional people achieving great things who don't apologize for their greatness, and doesn’t explicitly ask the patient - I mean, reader - for their opinion. If the reader has no strong opinion, or says something like "Good for them, I guess," she passes the test. "I like these people and will use them as a role model" also passes. Some specific criticisms (see below) may also pass. If the reader says "Ah, people who are better than the pathetic sheep around them, just like I'm better than all the pathetic sheep around me!", she . . . still passes the test. That's not what it's testing for! You fail the test if you absolutely freak out about some combination of the Rand characters themselves and the potential existence of arrogant people who identify with the Rand characters. The secret is that it's not a screening test for the kind of people who would get featured on /r/iamverysmart. It's a screening test for the kind of people who would comment on /r/iamverysmart, ie the self-designated Tall Poppy Police, ie the people who build their ego off being the enforcers of the rule that you're not allowed to look better than anyone else. These people's basic mental stance is to hate people who seem too excellent. They don't think of it in these terms. They think of it as calling out arrogance, although if you look too closely you'll find their definition of arrogance covers anyone who seems excellent and but doesn't spend all their time apologizing and abasing themselves and denying it. The brilliance of Teach-Rand is how he-she draws this tendency to the foreground For example, why the whole "Objectivism" thing? Not because value is necessarily completely objective, but because the idea that any value might ever be even partially objective freaks out the Tall Poppy Syndrome people. Mention value at all, and they say you must be trying to secretly smuggle in the assumption that you are more valuable than other people (and therefore you are less valuable than other people, and therefore they are better than you). The same is true of Reason. Mention that Reason exists, and they'll interpret it as a claim that you, the only rational person, are claiming to always be right and infallible. But (they retort) actually nobody knows anything, and the only wise people are the people like them who humbly admit this. (how do you decide what's true without Reason? By bias-based-reasoning - "You say X, but I can imagine a way that would come from a place of believing you're better than other people, therefore, Not-X is true. You say that's a logical fallacy? That must come from a place of believing you're smarter than everyone else and the only person who can use Facts and Logic.") The Teach-Rand test is designed to catch the sort of person who, if someone says that on a right triangle a^2 + b^2 = c^2, responds with "Oh, so you're claiming to be some kind of right triangle expert who's better than the rest of us? You really need to work on that arrogance problem! Super cringe!" Any criticism of the book that doesn't come from this particular place is irrelevant to the test and doesn't count against your grade. (which is good, because the books are bad in a lot of ways. But that's fine - Rorschach blots don't also have to be great art!) Still, I don’t think she’s the superman (superwoman?) who successfully transcends the dichotomy Her philosophy is only as strong as its proofs of Objective Correctness, which I consider weak. Without those, you need some subjective motivation to glue things together - of which altruism is the most popular. But also, don’t we like altruism? When we’re bestriding the Earth like colossi, working on our glorious rocket ships to colonize the universe, isn’t part of what we’re thinking “this is going to revolutionize humankind and make everybody better off?” If you force yourself to reject that motivation, to just repeat “no no no, I’m only doing this because rockets are really big and make cool explosions”, aren’t you cutting out a part of yourself, in exactly the way Nietzschean masters are supposed to try to avoid doing? I find something very compelling about Rand. I think she goes some of the way to answering the Andrew Tate objection to master morality. But she’s a means and not an end. A real superman would have to figure out some way to reintroduce basic human kindness. IX. Matt Yglesias Yglesias’s mantra - “good things are good” - is too perfect and profound to come from anyone other than an esoteric master of Nietzschean philosophy. Good Straussians ignore the title and focus on the subtitle. Nietzsche wrote in the 1890s. There were still real nobles and emperors walking around; communists had not yet started calling capitalism “late capitalism”. Sure, his world was probably some sort of weak compromise between master and slave morality, but it was different from our weak compromise. Our weak compromise was forged through dialogue and warfare with fascism’s novel take on master morality and socialism’s novel take on slave morality. I think of Yglesias - who combines an insistence that good things are good and a proclivity for embiggenment with commitments to democracy, the welfare state, and the poorest among us - as one of its most self-conscious proponents. When I first titled this post, I didn’t know that Richard Hanania had come to the same conclusion and created this face-mash-up of Matt Yglesias and Nietzsche. The compromise goes something like: Everyone is equal before the law, before the metaphorical throne of metaphorical God, and in some poorly defined philosophical sense. This is very important. It’s our headline result. Everything else should be interpreted in light of this central fact.
Inline links: a real answer here, https://substackcdn.com/image/fetch/$s_!OtNv!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F6ae1aaf2-6cc3-488c-b0a7-5df62eee457b_225x225.jpeg, Elsewhere, Sadly, Porn, /r/iamverysmart, https://substackcdn.com/image/fetch/$s_!MzIr!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Ff03d1a9d-5ffc-45ff-84bc-db3388915bbc_259x390.jpeg, https://substackcdn.com/image/fetch/$s_!hYvV!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fd0f9b152-da12-4525-b062-b4c14d8b8005_383x373.png
Peace Pact1 mentions across 1 issues

Peace Pact is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between July 01, 2022 and July 01, 2022. The archive places it in contexts such as "World War I happened before the Peace Pact, while World War II happened after"; "Whereas Ukraine most definitely can’t agree to that any time soon. It also is highly contrary to the kind of history that Putin used to justify his invasion. You very much do not get to keep whatever you happen to occupy when there is a formal peace settlement"; "before the Peace Pact there was no such thing as helping your friends while staying neutral". It most often appears alongside 1793, 1821, 1847.

Reference entry
Peace Pact
Mention count
1
Issue count
1
First seen
July 01, 2022
Last seen
July 01, 2022
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Your Book Review: The Internationalists
July 01, 2022 · Original source
"One school of thought is that Putin will consider himself entitled to keep any gains won on the battlefield, or at least any that it would make sense to keep. Whereas Ukraine most definitely can’t agree to that any time soon. It also is highly contrary to the kind of history that Putin used to justify his invasion. You very much do not get to keep whatever you happen to occupy when there is a formal peace settlement, that has never been how this works. For a guy who lectures us for hours about events from Europa Universalis this would be a very poor understanding of war score and formal borders." (emphasis added)
Except this has only been true since the Kellogg-Briand Pact. Prior to the Peace Pact, you absolutely did get to keep territory you took in war.
H&S carefully document and disprove five major claims about why the Kellogg-Briand Pact is irrelevant. I’ve added a sixth here, which they do not address, and a short section about it below.
Pearly Gates1 mentions across 1 issues

Pearly Gates is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between January 16, 2026 and January 16, 2026. The archive places it in contexts such as "I hope he gets his linguistic kill shot in on God and squeaks through the Pearly Gates". It most often appears alongside Adams, Alice, All-Seeing Eye.

Reference entry
Pearly Gates
Mention count
1
Issue count
1
First seen
January 16, 2026
Last seen
January 16, 2026
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The Dilbert Afterlife
January 16, 2026 · Original source
I hope he gets his linguistic kill shot in on God and squeaks through the Pearly Gates.
pediatric ALL1 mentions across 1 issues

pediatric ALL is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between January 27, 2022 and January 27, 2022. The archive places it in contexts such as "Will the exception of pediatric ALL (which is useful because it is a non-adult condition that relies on specialists for delivery)". It most often appears alongside ACA, Acrolectics, Aetna.

Reference entry
pediatric ALL
Mention count
1
Issue count
1
First seen
January 27, 2022
Last seen
January 27, 2022
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Highlights From The Comments On Health Care Systems
January 27, 2022 · Original source
First, the 6 illnesses seem, a priori, pretty relevant. Will the exception of pediatric ALL (which is useful because it is a non-adult condition that relies on specialists for delivery), these are all extremely common conditions. While the xkcd comic is very funny (they always are), I don't know that it's relevant here? They're not cherry picking a small feature of a bigger phenomena and then claiming that that cherry picked thing is driving the whole phenomenon; rather they're using some representative conditions to try to understand ways in which healthcare in the US may be surprising.
Pedophilia1 mentions across 1 issues

Pedophilia is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between January 25, 2023 and January 25, 2023. The archive places it in contexts such as "Pedophilia N is N worse N than N homosexuality N". It most often appears alongside DSM, DSM, DSM-III.

Reference entry
Pedophilia
Mention count
1
Issue count
1
First seen
January 25, 2023
Last seen
January 25, 2023
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You Don't Want A Purely Biological, Apolitical Taxonomy Of Mental Disorders
January 25, 2023 · Original source
But if you call something a mental disorder, people will accuse you of trying to stigmatize them, which is bad. The DSM writers are trans-friendly and want to make sure trans people can get the care they need (for example, in most states, people need a psych evaluation before they can get gender affirmation surgery), so they want to force insurance companies to cover transgender, so they have to include it. But they also don’t want to stigmatize trans people, so they also include a lot of paragraphs about how even though they just listed it as a mental disorder, it definitely isn’t a mental disorder. (a common claim is that the DSM says transgender itself is not a mental disorder, but the distress it produces is. This doesn’t seem especially destigmatizing to me - you’re the wrong gender, but you’re crazy for being unhappy about it? Also, I can’t find support for this distinction in a literal reading of the DSM criteria themselves) When the DSM is political, it’s not (just) because the authors are ideologues and want to go around stigmatizing people they don’t like. It’s because “is X a mental disorder or not?” is scientifically meaningless but politically very important. I’ll give an even worse example: from N a N biological N point N of N view N, homosexuality N and N pedophilia N are probably N pretty N similar. Both are “sexual targeting errors”: from an evolutionary point of view, our genes get passed down through couplings with sexually mature opposite-sex partners, and our instincts probably evolved to promote this. But instincts are hard - ducks sometimes decide humans are their mother and imprint on them - so sexual targeting errors are pretty common. I’m just speculating here - nobody has a strong evidence-based theory of either condition - but I think my speculations fit the small amount of evidence there is (for example, both are only weakly linked to genetics, suggesting they involve unconscious learning in some way). If this is accurate, the N relevant N difference N between N homosexuality N and N pedophilia N is N moral N, not N biological. Both are sexual targeting errors, but one re-targets sexuality onto other people who can consent and won’t be harmed, so it’s fine. The other targets people who can’t consent and will be harmed, so it’s bad. So N, should N your N purely N biological N, apolitical N, taxonomy N of N mental N disorders N classify N homosexuality N as N a mental N illness, N or N should N it N refuse N to N classify N pedophilia N as N a N mental N illness? We have to classify pedophilia as a mental illness, because we want insurance to pay for treatment. If someone shows up at a psychiatrist saying “Help, I feel an urge to molest children, is there anything you can do to get rid of that urge or prevent me from acting on it?”, I definitely want insurance to pay for this person’s treatment. Therefore, pedophilia “is” “a” “mental” “illness”, and no sophisticated categorization algorithm will ever convince me otherwise. That N means N that N a N purely N biological N apolitical N taxonomy N of N mental N disorders N which N classifies N all N things N with N similar N biological N causes N in N the N same N way N would N also N probably N classify N homosexuality N as N a N mental N disorder. But the whole point of wanting a purely biological apolitical taxonomy of mental illness was to make sure we would never again repeat the DSM’s error of calling homosexuality a mental disorder! The people asking for apolitical taxonomies want an incoherent thing. They want something which doesn’t think about politics at all, and which simultaneously is more politically correct than any other taxonomy. Or if “political correctness” sounds too dismissive, we can rephrase it as: “they want something that doesn’t think about ethics and practicality at all, but which is simultaneously more ethically correct and pragmatically correct than other taxonomies”. That is, we want our definition of “mental disorder” to be ethical (eg not stigmatize people who don’t deserve stigma). And we want it to be practical (eg identify a group of people who need and deserve care). But things that are biologically similar can be ethically and practically different: Hitting kittens is worse than hitting punching bags, even though the biology of the muscle movements is exactly the same.
Inline links: scientifically meaningless
Pedophilia N is N worse N than N homosexuality N, not N because N the N biology N necessarily N involves N different N processes N or N brain N regions, N but N because N it’s N important N for N your N sexual N partners N to N be N able N to N consent.
pedunculopontine nucleus1 mentions across 1 issues

pedunculopontine nucleus is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between September 30, 2022 and September 30, 2022. The archive places it in contexts such as "from PFC (either directly or via pedunculopontine nucleus and related structures)". It most often appears alongside 5HT2A serotonin, acetylcholine, Alice.

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September 30, 2022
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September 30, 2022
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Highlights From The Comments On Unpredictable Reward
September 30, 2022 · Original source
1. A "state prediction error" or general surprise signal from PFC (either directly or via pedunculopontine nucleus and related structures). This provokes phasic bursting of dopamine neurons in the Ventral Tegmental Area.
Peer review1 mentions across 1 issues

Peer review is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between January 07, 2022 and January 07, 2022. The archive places it in contexts such as "There’s a discussion starting here of the role of “peer review” in the movie"; "part of my feeling like this was trying to trivialize the difficulty of interpreting science came from the attempt to use “peer review” as some sort of weird Legitimacy Totem". It most often appears alongside ACX Discord, Aerojet XLR-132, Aimable.

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Peer review
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January 07, 2022
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January 07, 2022
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Highlights From The Comments On "Don't Look Up"
January 07, 2022 · Original source
There’s a discussion starting here of the role of “peer review” in the movie. In short: the reason Male Scientist doubted Tech CEO’s plan to surgically disassemble the comet was because it “wasn’t peer reviewed”.
Inline links: here
Peer review is a really trivial bar; all sorts of awful homeopathy and ESP and psionics studies have gotten “peer-reviewed”.
Yeah, yeah, just a movie, okay, but part of my feeling like this was trying to trivialize the difficulty of interpreting science came from the attempt to use “peer review” as some sort of weird Legitimacy Totem - as if it were a reliable test to separate good science from bad.
peer-reviewed results1 mentions across 1 issues

peer-reviewed results is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between April 07, 2021 and April 07, 2021. The archive places it in contexts such as "peer-reviewed results (or at least it doesn’t always put you there)". It most often appears alongside academic science, Ahtiainen et al., Altmetric.

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peer-reviewed results
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April 07, 2021
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April 07, 2021
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Metis And Bodybuilders
April 07, 2021 · Original source
I appreciate the many ways that science and evidence can go wrong, and the unique expertise held by communities of metis-possessing practitioners. But in most of the communities I look into, trusting the peer-reviewed academic studies still seems to be the way to go.
The most important lesson I draw from this is that metis and a community doing practical work doesn’t put you above academic science and peer-reviewed results (or at least it doesn’t always put you there). The bodybuilders had lots of opportunities to experiment and tinker, with lots of skin in the game, but they were still getting things pretty wrong until researchers looked into some of their conclusions using the normal scientific method.
PEG coatings1 mentions across 1 issues

PEG coatings is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between June 18, 2025 and June 18, 2025. The archive places it in contexts such as "testing these PE coatings, alongside PEG coatings, on our membranes"; "We have continued testing these PE coatings, alongside PEG coatings, on our membranes". It most often appears alongside 1DaySooner, Aatu Koskensilta, acanthamoeba keratitis.

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PEG coatings
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ACX Grants 1-3 Year Updates
June 18, 2025 · Original source
Minnesota and Virginia also have legislation to enable cities to implement land value taxes. We are monitoring these efforts. There are a few other cities we are operating in. We have helped another organization prepare for a meeting in Tennessee by doing impact analysis of land value taxes in the city. We have presented to city officials in the City of South Bend who have expressed support for land value taxes. Finally, we are in conversation with a State Senator in Colorado who is a champion of land value taxes. Meanwhile, we have soft launched and developed the OpenAVMKit, which uses a unified schema to do assessment accuracy reports and automated valuation methods for any property tax data given. Valuation of land is the key binding constraint to successful implementation of land value taxes. We plan to be the leaders in this space with strong benchmarking capabilities and a repo that can enable the open-source community to make the best automated valuation methods. Along with these efforts, we have expanded the movement. We have posted to the Progress and Poverty Substack growing the subscriber base to around 5,000 subscribers. We have spoken to over 25 local advocates interested in working on land value taxes in their local communities. Yet, there is a long way to go. We need to start earning income through technical assistance contracts as our grant funding expires. We need to continue pushing for a state to implement, and we need to be prepared to tell the success story for when they do. 65: EN’s Work On Bacteriophage Therapy Our project is aimed at pioneering phage therapy in Nigeria, where limited resources/infrastructure have historically held back research in this field. Starting from the ground up, we are establishing the foundational systems needed to support a robust phage research ecosystem. So far, we’ve isolated 34 bacteriophages targeting Pseudomonas aeruginosa, an essential step toward building a comprehensive phage bank. This began with collecting a wide range of clinical Pseudomonas isolates, which we are now characterizing alongside the phages through genome sequencing and phenotypic assays including studies on phage stability across pH, temperature, and salinity ranges. Our long-term goal is to develop a phage-based hydrogel for treating diabetic wounds. On the regulatory front, we have secured approval from the Attorney General to register our nonprofit organization, the Centre for Phage Biology and Therapeutics. Additionally, we’re expanding into vaccine development; following a research stay in Prof. Roderick's lab at the University of Waterloo, we have initiated the design of a phage-based universal Salmonella vaccine aimed at covering all major serotypes—an urgent need underscored by Africa’s reliance on external vaccine sources during the COVID-19 pandemic. I have signed an MTA agreement with Roderick to use his phage-based vaccine platform patents to enable us to design vaccines against any common disease affecting us. This is only the beginning, but we are proud to be laying the scientific and institutional groundwork for homegrown phage innovation in Africa. Emergent Ventures funded EN before we did and deserves a lot of credit here also. 66: Create An Artificial Kidney For an implantable artificial kidney, the first essential component is a hemofilter designed to emulate the glomerulus. Critical requirements for this hemofilter include high permeability (to maximize flow for a given area), selectivity (specifically, the retention of albumin), and robust blood compatibility (ensuring sustained function over time). Our initial strategy focused on using negative surface charge to reduce fouling. I began by testing polyelectrolyte (PE) coatings on 24nm pore membranes featuring a negative terminal charge, similar to the glomerular barrier. These initial static tests, assessing platelet adsorption in whole blood, yielded positive outcomes for some polyelectrolytes, indicating potentially desirable blood compatibility. However, static test setups are not truly representative of dynamic in-vitro conditions and don't provide data on key parameters like permeability, fouling progression, or changes in membrane selectivity. To address these limitations, I designed and built a blood filtration setup. This system sustains human whole blood in circulation for 20 minutes, allowing us to analyze all the aforementioned parameters, as well as platelet activation markers. This has resulted in a fairly high-throughput system for evaluating any surface coating. I'm pleased to report this setup has been accepted for presentation at this year's European Society for Artificial Organs (ESAIO) conference. I am also currently working on a full manuscript, as I believe this system offers a viable way to partially replace animal experiments in our early-stage research, requiring only 1.2ml of human blood per run. Working with a PhD student (hired to support both this research and work on membrane substrates), we have continued testing these PE coatings, alongside PEG coatings, on our membranes. Here, we're finding that optimization of the coating layer is crucial. With the current PE coatings, we observe a permeability drop of about an order of magnitude compared to the base membrane, making them unsuitable for an implantable device in their present form. This is likely due to the specific nature of the initial PE layer, which we can modify. We also suspect there may be ingress of PE into the pores, meaning we're not achieving just a surface coating (our goal), but rather a very thick coating, which would explain the flux loss. Optimizing the coating process to control penetration depth is now a primary focus of my ongoing work. I am currently aiming for a flux of 20ul/min (as this is cap introduced by the protein gel layer anyway) but for it to be at this 'steady state' permeability without drop in permeability. I am also imaging the membranes after contact with SEM to see if there is indeed any platelet adsorption etc. Tugrul has the dubious honor of maybe being "the only person to climb a 4000m peak with severe kidney failure". To raise money and awareness for his artificial kidney project, he is running Climb Against Time, where he will climb 41 mountains over 4000m (13000 ft) this summer. He is looking for donors and climbing partners. 67: Add Tardigrade Genes To Human Cells The goal of this one was to make hybrid cells that are more resilient for research and certain medical applications. They report: The grant was to synthesize vectors for the expression of humanized tardigrade proteins that can be targeted to different areas of the cell. All the vectors were designed, generated, and transposed into human cells. The proteins all localize successfully (e.g. they match the designed target), with one exception (we are still working on validating it). We've done some stress testing with the trangenic cells, but haven't reached firm conclusions yet. We've further generated some multigene designs but have not yet transposed them into cells, but should shortly. We're hoping to submit a manuscript on the first round later this year. 68: Teach Forecasting To EU Policy-Makers The original project didn't work out, but our grantee (who still prefers to remain anonymous) is now working with an EU think tank pursuing the same agenda, and has been teaching forecasting workshops to policy-makers for the past two months. 69: Platform For Single-Cell Imaging They ended up unable to accept this grant and returned the money. 70: Open Source Polygenic Predictor For EA/IQ They have an update here. They think they have a predictor that can explain 12% of variance in intelligence, and they’re working on validating it and creating an easy-to-use website. 71: Improve Flu Vaccines The grant mainly funded agent based modelling to demonstrate the benefit of pre-existing immunity to pandemic influenza if and when a future pandemic occurs (academic publication will result). The original proposal was to attempt to influence the WHO influenza strain selection process. After attending WHO meetings and a global influenza conference, I believe this is not feasible. Stakeholder feedback was the potential short term negative effect on vaccine hesitancy is believed to outweigh the less tangible future benefit. Given the conservative nature of decision makers, pandemic vaccines are likely to remain research only. There are still green shoots of research into pandemic preparedness/prevention that I am continuing to work on. I'm working under the "Australians for Pandemic Prevention" brand of Good Ancestors, another group that ACX funded in 2024. 72: Scenario Analysis For Developing World Agricultural Programs In addition to the research and analysis funded by the grant, I’ve learned to code with LLMs and have built an MVP of the project. The app is being considered for further development by staff at a large international organization. 73: Further C’s Political Career C’s political career is going well, but he continues to think it wouldn’t be strategic to give more information publicly at this time. Lessons Learned I'm most impressed with our lobbying/advocacy organizations. In particular, Good Ancestors has gotten the Australian government to sign onto an international AI safety declaration, partner with various x-risk-related organizations, and (possibly) extend charity tax deductions to some EA causes that previously didn't have it - I think this on its own goes a substantial way to paying back the cost of all ACX Grants. Coalition to Modify NOTA has a kidney donation bill in front of Congress that the (very illiquid) prediction markets give a 45% chance of passing; if it works, it could save thousands of lives. The Georgists are partly responsible for bills making land value taxes slightly easier to implement in a handful of states. Good Science Project seems to have significantly improved science. Are lobbying organizations a better bet than other types of nonprofit (within the constraints of ACX Grants)? I'm not sure. It could just be that lobbyists are (naturally) better at playing themselves up and sounding successful than (for example) scientists, or that politicians are good at people-pleasing and make people feel heard and encouraged in a way that might not change overall policy later. Also, I recently talked to some grantmakers who funded a lobbying organization that superficially seems excellent, but they expressed concern it was net negative (!) by taking away oxygen and spotlight from potentially more effective orgs. So I am encouraged but wary. Animal welfare organizations were another standout success. Again, I don't know how to think about this - while I think our grantees were exceptional, there's also an issue where the scale of animal welfare challenges is so great, and work on them so neglected, that lots of organizations can save a million chickens here, or a million fish there, without particularly making a splash. On the one hand, this is exactly what effective altruism should be doing - exploring grants that are very high in linear utility even if they don't feel satisfying. On the other, they're unsatisfying - and also hard to assess retroactively. How many chickens should a good animal welfare grant save? Any realistic number will both be overwhelmingly large in absolute terms and far too small in relative terms. I'm most ambivalent about our science grants. Many of them say they are successful and can point to published papers which explain the science they did. But it's hard to judge whether anything useful has changed based on the science getting done. I know it's important to fund basic research and not just last-mile technology startups, but it's hard for a mini-grants program like this one to evaluate these kinds of abstract interventions. One disappointing result was that grants to legibly-credentialled people operating in high-status ways usually did better than betting on small scrappy startups (whether companies or nonprofits). For example, Innovate Animal Ag was in many ways overdetermined as a grantee - former Yale grad and Google engineer founder, profiled in NYT, already funded by Open Philanthropy - and they in fact did amazing work. On the other hand, there were a lot of promising ACX community members with interesting ideas who were going to turn them into startups any day now, but who ended up kind of floundering (although this also describes Manifold, one of our standout successes). One thing I still don't understand is that Innovate Animal Ag seemed to genuinely need more funding despite being legibly great and high status - does this screen off a theoretical objection that they don't provide ACX Grants with as much counterfactual impact? Am I really just mad that it would be boring to give too many grants to obviously-good things that even moron could spot as promising? Someone (I think it might be Paul Graham) once said that they were always surprised how quickly destined-to-be-successful startup founders responded to emails - sometimes within a single-digit number of minutes regardless of time of day. I used to think of this as mysterious - some sort of psychological trait? Working with these grants has made me think of it as just a straightforward fact of life: some people operate an order of magnitude faster than others. The Manifold team created something like five different novel institutions in the amount of time it's taken some other grantees to figure out a business plan; I particularly remember one time when I needed something, sent out a request to talk about it with two or three different teams, and the Manifold team had fully created the thing and were pestering me to launch a trial version before some of the other people had even gotten back to me. I take no pleasure in reporting this - I sometimes take a week or two to answer emails, and all of the predictions about my personality that this implies would be correct - but it's increasingly something that I look for and respect. A lot of the most successful grants succeeded quickly, or at least were quick to get on a promising track. Since everything takes ten times longer than people expect, only someone who moves ten times faster than people expect can get things done in a reasonable amount of time. In almost every case where I thought to myself “this is a cool idea, but I don’t know how it’s going to really pay off, as opposed to reaching a cool intermediate accomplishment and then stagnating”, this was a correct criticism, and I should have taken it more seriously. But I can’t rule out that these were good in vague and hard-to-measure ways that I should take more seriously. This one is really self-serving, but in general when people were good communicators (or even bloggers) and wowed me with the writing-composition of their application, they turned out to be a good bet. And when people were hard to understand and annoying to communicate with, even if their ideas seemed good, they were less likely to pan out. Overall Thoughts The total cost of ACX Grants, both rounds, was about $3 million. Do these outcomes represent a successful use of that amount of money? Very naively, startups originating from ACX Grants have about $50 million in value1. If ACX Grants is equivalent to a pre-seed funder, and pre-seed funders usually get ~5%, then if we were VCs we would have a portfolio worth $2.5 million. About 1/5 of ACX Grants were attempting to be market-valued startups, so if we assume the charitable portion did about as well as the startup portion, then the charity portion is “worth” $10 million. There’s some reason to expect this is too high, since much of the startup value came from one successful outlier. But there’s another reason to expect this is too low, since we were aiming at charity rather than market cap, and any actual market cap that our grantees got was an unexpected side effect. I’m treating this as a sanity check rather than as a real number. It’s harder to produce Inside View estimates, because so many of the projects either produce vague deliverables (eg a white paper that might guide future action) or intermediate results only (eg getting a government to pass AI safety regulations is good, but can’t be considered an end result unless those regulations prevent the AI apocalypse). Because we tend towards incubating charities and funding research (rather than last-mile causes like buying bednets), achieved measurable deliverables are thin on the ground. But here are things that ACX grantees have already accomplished: Improved the living/slaughter conditions of 30 million fish.
Inline links: Progress and Poverty Substack, Climb Against Time, here, 1
pegasus1 mentions across 1 issues

pegasus is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between April 12, 2021 and April 12, 2021. The archive places it in contexts such as "it was a mythical animal akin to the chimera or pegasus". It most often appears alongside A Whirlwind Tour Of Ethereum Finance, Agan, Air Force Chapel.

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pegasus
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April 12, 2021
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April 12, 2021
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Links For April
April 12, 2021 · Original source
16: Before Europeans applied the word “panther” to the big cat found in Asia / the Americas, it was a mythical animal akin to the chimera or pegasus (its name comes from pan+therion, “all animals”, and it was probably originally one of those “head of an X, body of a Y, tail of a Z” deals). Read more here, but mentioning this at all is an excuse to show you this picture of a mythical panther from the heraldry of Henry VI:
Inline links: here, heraldry of Henry VI
penicillin1 mentions across 1 issues

penicillin is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between July 18, 2024 and July 18, 2024. The archive places it in contexts such as "once there were other options (penicillin, antipsychotics, nursing homes)". It most often appears alongside Access Pass, Africa, America.

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penicillin
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July 18, 2024
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July 18, 2024
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Highlights From The Comments On Mentally Ill Homeless People
July 18, 2024 · Original source
Actual schizophrenics Around the 1950s, lifespans increased enough that it was worth coming up with separate institutions (eg nursing homes) for demented people. Penicillin cured neurosyphilis. Better prenatal testing decreased Down’s syndrome rates, and better social services let Down’s syndrome patients be treated in the community. It became harder to bribe people to imprison your eccentric relatives. And pharma companies invented antipsychotics to treat schizophrenics. So the effective population for these institutions decreased by an order of magnitude. At the same time, rising health care costs were making them unmaintainably expensive. And yes, civil rights advocates were arguing that they were violations of human rights. So between 1950 and 1980, they were almost all closed down. Recreating this system would be tough, both for practical and political reasons. The practical reason is that the cost of everything has increased by at least an order of magnitude since 1950. Partly this is increasing social and governmental dysfunction. Partly it’s because in 1950, it was considered reasonable to build institutions that looked like this: Cozy! Even at costs likely 10% of ours, the 1950s couldn’t really afford to keep these institutions around; states were spending about 10% of their total budget just to maintain buildings that looked like the picture above. That segues into the political problem - once there were other options (penicillin, antipsychotics, nursing homes), the public willingness to pay to maintain the institutions collapsed. On the other hand, when I calculate this out, it doesn’t seem so bad? The average cost of a psychiatric hospital bed is about $300K per year (sanity check: a California prison bed is $130K per year, and the psych hospital needs more medical personnel, so this seems plausible). There are about 8,000 homeless in San Francisco, but assume that most are ordinary people down on their luck, and we only need to institutionalize 2,000. That suggests a cost of $600 million/year using state-of-California numbers, but everything (eg real estate) is more expensive in SF, so round up to $1 billion/year. I don’t know if this counts the amortized cost of building the institution, but let’s assume it does. San Francisco currently spends about $1 billion/year on homelessness. These institutions would only cover the worst 25% of homeless people, so you’d need maybe another $500 million for the rest, but whatever, same order of magnitude. I think this is more affordable than I expected. The remaining problems are: Where is this? I don’t think there’s anywhere in SF city limits to put it. I suggest putting it in Marin, to piss off George Lucas’ neighbors. But I don’t know about the legalities of a city using an extraterritorial detention institution.
Inline links: https://substackcdn.com/image/fetch/$s_!eZXJ!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fec410560-b6b1-4f73-91bc-25f377fb8266_800x533.jpeg, about $300K per year
Cozy! Even at costs likely 10% of ours, the 1950s couldn’t really afford to keep these institutions around; states were spending about 10% of their total budget just to maintain buildings that looked like the picture above. That segues into the political problem - once there were other options (penicillin, antipsychotics, nursing homes), the public willingness to pay to maintain the institutions collapsed. On the other hand, when I calculate this out, it doesn’t seem so bad? The average cost of a psychiatric hospital bed is about $300K per year (sanity check: a California prison bed is $130K per year, and the psych hospital needs more medical personnel, so this seems plausible). There are about 8,000 homeless in San Francisco, but assume that most are ordinary people down on their luck, and we only need to institutionalize 2,000. That suggests a cost of $600 million/year using state-of-California numbers, but everything (eg real estate) is more expensive in SF, so round up to $1 billion/year. I don’t know if this counts the amortized cost of building the institution, but let’s assume it does. San Francisco currently spends about $1 billion/year on homelessness. These institutions would only cover the worst 25% of homeless people, so you’d need maybe another $500 million for the rest, but whatever, same order of magnitude. I think this is more affordable than I expected. The remaining problems are: Where is this? I don’t think there’s anywhere in SF city limits to put it. I suggest putting it in Marin, to piss off George Lucas’ neighbors. But I don’t know about the legalities of a city using an extraterritorial detention institution.
Inline links: about $300K per year
Penn Treebank1 mentions across 1 issues

Penn Treebank is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between April 04, 2022 and April 04, 2022. The archive places it in contexts such as "on something called Penn Treebank perplexity, a benchmark for measuring how good language models are"; "Eliezer doesn’t care about boring things like Penn Treebank". It most often appears alongside 2013, Agricultural Revolution, AI.

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Penn Treebank
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1
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April 04, 2022
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April 04, 2022
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Yudkowsky Contra Christiano On AI Takeoff Speeds
April 04, 2022 · Original source
In the comments, Matthew Barnett points out that on something called Penn Treebank perplexity, a benchmark for measuring how good language models are, the GPTs mostly just continued the pre-existing trend:
The impact of GPT-3 had nothing whatsoever to do with its perplexity on Penn Treebank . . . the impact of GPT-3 was in establishing that trendlines did continue in a way that shocked pretty much everyone who'd written off 'naive' scaling strategies. Progress is made out of stacked sigmoids: if the next sigmoid doesn't show up, progress doesn't happen. Trends happen, until they stop. Trendlines are not caused by the laws of physics. You can dismiss AlphaGo by saying "oh, that just continues the trendline in ELO I just drew based on MCTS bots", but the fact remains that MCTS progress had stagnated, and here we are in 2021, and pure MCTS approaches do not approach human champions, much less beat them. Appealing to trendlines is roughly as informative as "calories in calories out"; 'the trend continued because the trend continued'. A new sigmoid being discovered is extremely important.
In other words, suppose AIs start at Penn Treebank perplexity 100 and go down by one every year. After 20 years, they have PTP 80 and are useless. After 21 years, they have PTP 79 and are suddenly strong enough to take over the world. Was their capability gain gradual or sudden? It was gradual in PTP, but sudden in real-life abilities we care about.
pennyroyal1 mentions across 1 issues

pennyroyal is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between August 26, 2022 and August 26, 2022. The archive places it in contexts such as "knows the names of all the flowers and which ones can be used in abortions (pennyroyal)". It most often appears alongside 1917, aesthetics, American.

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pennyroyal
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1
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1
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August 26, 2022
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August 26, 2022
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Your Book Review: Kora In Hell
August 26, 2022 · Original source
What they very clearly state is that in middle life, WCW is very horny all the time. He drives around town and countryside, watches people, gets horny, then even hornier, talks to people, has a great ear for their voices, a great medical eye for little details, knows the names of all the flowers and which ones can be used in abortions (pennyroyal), then gets home and writes. The style is part aphoristic and part like the highbrow version of passive-aggressive Tweets, where you know the people you’re talking about might be reading and you want plausible deniability. Both the town and the artist circles WCW moved among were small communities, where everyone knew everyone else and probably could infer the specific person you were talking about when you said, for example:
Penrose-Hameroff1 mentions across 1 issues

Penrose-Hameroff is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between October 25, 2022 and October 25, 2022. The archive places it in contexts such as "If we learned that the brain used spooky quantum computation a la Penrose-Hameroff". It most often appears alongside 80,000 Hours, ACX Grants, Andrew Ng.

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Penrose-Hameroff
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1
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1
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October 25, 2022
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October 25, 2022
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From The Mailbag
October 25, 2022 · Original source
If we learned that the brain used spooky quantum computation a la Penrose-Hameroff, that might reassure me; current AIs don’t do this at all, and I expect it would take decades of research to implement. But maybe AIs could do things without spooky quantum computation, even if the brain doesn’t. I would be most reassured if I learned that the quantum computation was necessary for some task that current AIs are very bad at, like learning from minimal training data.
Inline links: Penrose-Hameroff
Pentecostalism1 mentions across 1 issues

Pentecostalism is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between April 21, 2021 and April 21, 2021. The archive places it in contexts such as "Pentecostalism in particular is hip and willing to adapt itself to Latin American culture". It most often appears alongside Andes Mountains, Antiochan subgroup, Argentina.

Reference entry
Pentecostalism
Mention count
1
Issue count
1
First seen
April 21, 2021
Last seen
April 21, 2021
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No, Really, Why Are So Many Christians In Colombia Converting To Orthodox Judaism?
April 21, 2021 · Original source
Juan Carlos went along. “Sometimes when I was reading the Bible to myself, they would ask me to read aloud so that they could all hear,” he told journalists. The lie turned him into a celebrity. He had become the pastor who had converted the anti-religion Elenos. But as he toured churches telling the story of his release, he began to feel guilty. “People were being deceived, lied to, manipulated,” he says. He felt ashamed about what he had put his family through as well. By abandoning college and becoming a pastor, he had shattered his father’s dream of creating a small agricultural business together. Now he had cost his father every cent he had saved. He was living off other people’s illusions. What was he doing in his own church? He became acutely aware of how Pentecostalism — how he — exploited the parishioners, passing off psychological and emotional manipulation as divine intervention. His faith was untouched, but he needed to find a new way of connecting with God.
Still, Orthodox Judaism? The articles linked above talk about why Mormonism and Pentecostalism are winning converts in Latin America. Both put lots of effort into missionary work (Judaism actively discourages conversion). Pentecostalism in particular is hip and willing to adapt itself to Latin American culture in a way that Catholicism isn’t - “The music that you hear in Pentecostal churches has the same rhythms that people enjoy outside of church” (Orthodox Judaism is about the least-hip and least Latin-American-culture-compatible religion imaginable). The number one reason cited by new Latin American converts to Protestantism is that they are “seeking a personal connection with God” (Orthodox Judaism almost aggressively avoids providing this). And converting to Orthodoxy is not a small step:
Inline links: actively discourages conversion, willing to adapt, number one reason
Per capita1 mentions across 1 issues

Per capita is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between April 16, 2021 and April 16, 2021. The archive places it in contexts such as "("Per capita" being the Latin for 'by head')". It most often appears alongside "The Rent Is Too Damn High!", 16th amendment, 1886.

Reference entry
Per capita
Mention count
1
Issue count
1
First seen
April 16, 2021
Last seen
April 16, 2021
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Your Book Review: Progress And Poverty
April 16, 2021 · Original source
After the Great Depression in the 1930's, we see a sharp decrease in the duration and frequency of recessions. They're still with us now (and the one we're currently in is the worst since the Great Depression), but you'd still rather be living in 2021 than 1879. So, have we solved the problem? Is George's complaint obsolete? I mean, this graph of GDP per capita from Stephen Pinker's Enlightenment Now makes it look like in many ways things are getting better: And heck, extreme poverty has been going down everywhere: But this can't be the entire picture, or nobody would be complaining about poverty and inequality. Here - this graph (source), shows that as consumer goods have gotten cheaper in the United States, health care, higher education, child care, etc., have skyrocketed in price, which Scott examined in great detail in Considerations on Cost Disease. And what about Inequality? In the USA it seems to have reverted to levels not seen since the Great Depression, and even when it was at its lowest in 1978, the top 0.1% (not even the top 1%!) still enjoyed a massively disproportionate share of Wealth (source): And of course, The Rent Is Too Damn High: (source): (source): Although 2021 seems better than 1879 in absolute material terms, George's complaint still rings true: healthcare and higher education are increasingly unaffordable, inequality is as bad as it ever was, and The Rent Is Too Damn High. And even if all of these measures had improved as well, we still have to contend with a fundamental complaint: how can human civilization have piled up an amount of wealth best described as absolutely banana pants insane, and yetstill have poverty, oppression and cyclical recessions? Yes, greed, evil, and human nature will always be with us, but isn't it weird that we haven't eliminated these economic problems the same way we've eliminated Smallpox, Scurvy, and having to write your scathing polemics about Thomas Jefferson by candlelight with a goose feather? Giving the mic back to George, he closes the chapter with this haunting quote, first written 142 years ago: If there is less deep poverty in San Fran Francisco than in New York, is it not because San Francisco is yet behind new York in all that both cities are striving for? When San Francisco reaches the point where New York now is, who can doubt that there will also be ragged and barefooted children on her streets? I'll just leave this here: Number of Homeless Children in U.S. At All-Time High; California Among Worst States. I. Wages and Capital George insists sloppy terminology leads to sloppy thinking. Naturally, he spends an entire chapter beating words to death to correct this. The Meaning of the Terms Let's start with Wealth. The common usage, both then and now, is "anything with an exchange value." George doesn't like how this mixes dissimilar things. By George, what is wealth? Wealth is produced when Nature's bounty is touched by human labor resulting in a tangible product that is the object of human desire. Labor is required, but the amount and type doesn't matter - George offers the example of simply picking a berry off a bush as an act that transforms nature's gifts into human wealth. Note particularly that human desire is an important requirement of wealth; it doesn't matter how much work someone put into something, if it doesn't gratify human needs or desires in some way, it's not wealth. Speaking of human desire, let's talk about Value. Where does a thing's value come from? The prevailing theory of the day was the Labor Theory of Value which originated with Adam Smith and David Ricardo, which says that Labor is the source of value. The early formulations were a bit ambiguous, here's Smith in Wealth of Nations for instance: The value of any commodity ... is equal to the quantity of labor which it enables him to purchase or command. Labor, therefore, is the real measure of the exchangeable value of all commodities. So... is a thing's value how much labor it takes to make the thing, or how much labor someone's willing to exchange for the thing? Nowadays Labor Theory of Value is most commonly associated with Marx. Marx picks a lane and says the value of something is tied to the amount of "socially necessary labor" required to produce it. George goes the other way: It is never the amount of labor that has been exerted in bringing a thing into being that determines its value, but always the amount of labor that will be rendered in exchange for it. - Henry George, The Science of Political Economy, p. 253 In other words, "a thing's value is whatever someone is willing to pay for it." This is in line with the so-called marginal revolution (the movement, not the blog) and modern theories of value. Labor Labor is the exertion of human beings. It's possible to labor to no avail (try punching a concrete wall), but typically humans labor towards an end, such as gaining wealth. But whether or not we accomplish anything with our efforts, George calls them labor. Labor isn't just making things, by the way – it's also moving or exchanging them. Production Production is labor applied "to the production of wealth." You know, productively. This is all human exertion that isn't punching a concrete wall and rewards you for your efforts with something that fits the definition of wealth. Said wealth is the "product of labor." Wages whatever is received as the result or reward of exertion is "wages." No distinction here is made between blue-collar work and white-collar work – whether one is called "hourly pay" and the other is called "annual salary," George calls them both "wages." It doesn't matter whether you receive them from your boss, from customers, or from nature. If you do work and get something from it, you have received "wages." With those basics under our belt, let's circle back to Wealth: What are some examples of wealth? By George, Gold is wealth. Teddy bears are wealth. Tesla roadsters and candy canes and young adult vampire romance novels are wealth. The same goes for fish you've caught, deer you've hunted, and cool looking rocks you've picked up on your morning walk. The value of these things may differ, but as long as they're tangible, originate in nature, someone ever did a lick of work to make or acquire them, and a human being somewhere desires them for any reason, they're wealth. It gets a little clearer when we ask what isn't wealth. And by George, Money isn't wealth. Articles of gold are wealth because they're tangible things that have been dug up, crafted, and fulfill certain human desires. But paper currency, digital currencies, and other things that aren't inherently valuable but merely represent value are not wealth (outside of putting their physical articles in coin collections or making paper airplanes, and so forth). Now don't get the man wrong, these things are certainly valuable. They're just not wealth. They are certificates that represent claims on wealth. For any computer programmers in the audience, money is a pointer to wealth. Likewise Stocks and Bonds and other financial instruments are not wealth. These are also just claims on wealth. A creditor's title to Debt isn't wealth, either, it's just a claim on the debtor's (typically future) wealth. And, writing as he was not long after the Civil War, George points out that Slaves are not wealth either but, represent "merely the power of one class to appropriate the earnings of another class." Wealth, thus defined, is the terminal "ground truth" bits of the economy, and all the financial layers on top are fancy IOUs that just encode various claims on it. George offers a thought experiment to test if something is wealth: if you produce a pile of gold, fish, or Lego bricks, you've clearly increased the amount of wealth in the world. But if you produce a giant pile of IOUs that just records who owns what and who owes what to whom, it doesn't matter how many of them you pile up or how long the chains of ownership get, you still haven't increased the amount of real wealth in the world. Again, this isn't saying the IOUs aren't valuable, they are. But they're only valuable because they ultimately point to real wealth. If you magically transported everyone over to a hypothetical Earth 2, carrying over all of Earth 1's money and financial instruments but none of Earth 1's tangible wealth, the value of all those IOUs would instantly evaporate. Now what about digital goods? Leaving things like Bitcoin aside for the moment, let's consider the case of a digital image file: By George, this is wealth. Digital though it may be, it's physically encoded on a storage device somewhere, and is thus tangible (it's not a pure abstract concept flitting about in Platonic heaven) and has its origins in nature. Human exertion built the computer that encodes it, and clicking the button that saves it to disk or displays it on your screen is labor. Finally, it directly satisfies human desires (mine, at the very least). It's value may be negligible, but it's wealth. By contrast, the digital bit sitting in some database that says I own a particular eBook or mp3 is just a digital IOU – a claim on the wealth that are the physical bits on my local storage device or remote server that digitally encodes the files. The fact that digital files don't seem particularly physical, and that they can be trivially and endlessly copied, doesn't mean that Henry George, magically transported to today, wouldn't regard them as wealth. Okay, so is there anything else that's not wealth? By George, Bitcoin isn't wealth, in case you were wondering. It's just a (very fancy) financial instrument, a digital claim on wealth. And that goes for most crypto assets – a token on some blockchain that says I own a painting by Banksy is just another IOU, regardless of the technical sophistication of its distributed trustless ledger. What about intellectual property? Copyrights, patents, and trademarks are all different forms of Monopoly – the exclusive, government-granted legal right to do a particular thing (publish a certain book, manufacture a certain product, use a certain name in business, etc). The exclusive right to do or produce a thing, valuable as it may be, is not the thing itself. By George, Monopoly is not wealth. But there is something big that is wealth – the C-word. Capital. By George, Capital is "wealth devoted to procuring more wealth", and it's the next thing he insists everyone is hopelessly confused about. He quotes Adam Smith, agreeing with him thus far: That part of a man's stock which he expects to afford him revenue is called his capital. ...and also gives us a short etymology lesson on the origin of the term: The word capital, as philologists trace it, comes down to us from a time when wealth was estimated in cattle, and a man's income depended upon the number of head he could keep for their increase. ("Per capita" being the Latin for "by head") By George, all capital is wealth, but not all wealth is capital. George notes capital is often described as being "stored up labor", and endorses this view – but what it really means, is capital is stored up production. It's not literally the labor that's stored up but the wealth generated by it, set aside and then dedicated to the purpose of getting more wealth. George insists that it is the owner's intention that transforms wealth into capital. If you buy an old factory to throw parties in for your hipster friends, it's just wealth. But the minute you decide to put it to work to make something useful (or start charging your hipster friends a cover charge at the door), it becomes capital. George therefore further insists that a laborer's daily bread and the clothes on their back do not count as capital, because a person has to eat and wear clothes whether they work or not. The laborer's tools (and arguably their steel-toed work boots) can however be counted as capital, because their purpose is to assist the laborer in getting more wealth by working for wages, and the laborer wouldn't acquire, use, and maintain those things otherwise. George has more exclusions: We must exclude from the category of capital everything that may be included either as land or labor. Human exertion (labor) by itself can never be capital. The products of human labor become capital when they are stored up and set to the purpose of getting more wealth. To muddle this distinction defeats the point of having separate terms for those things at all, and prevents us from reasoning meaningfully about how they relate to one another. Labor is not capital, and neither is labor by itself wealth, it produces wealth – and if it ain't wealth, it ain't capital. And that brings us to land. Land, land, land. By George, land is not wealth. And it's definitely not capital. The unique specialness of land is George's entire schtick and the very core of his philosophy. The term land embraces, in short, all natural materials, forces, and opportunities That means that a field or a meadow is "land", as is a mountain. But so are the fish in the sea, the clouds in the sky, veins of gold in the earth's crust, and the oil deep under ground. These things aren't yet wealth – not until human beings both a) desire them and b) touch them with labor. So... land is not wealth. But... how come? I mean, look: land is tangible, it "comes from nature", humans are always productively applying their labor to it, and it certainly seems capable of gratifying human desires. George sees this reasoning as understandable, but insists it's the root mistake that leads other political economists astray – because for George, land just is nature itself. Come again? Land is the ultimate source of all wealth, but it's most useful to think of it as a generator, acompletely separate entity from the wealth that human labor and desire draws from it. Players of Magic: the Gathering and Settlers of Catan should already have a solid grasp of this distinction: In modern times, George would grant electromagnetic spectrum and orbital real estate for satellites the same status of "land" that already applies to farmland and terrestrial real estate. We don't even need to speculate about whether he'd attach this status to sunlight because he straight-up predicted solar power: Even the lack of rain which makes some parts of the globe useless to man, may, if invention ever succeeds in directly utilizing the power of the sun's rays, be found to be especially advantageous for certain parts of production. (That's from Protection or Free Trade, footnote 19) The important thing to grasp about land is that it comes before everything humans do or make, and is itself a thing no human can make. Okay, smarty-pants, what about the Netherlands? They've been making land for centuries! Well, land in the Georgist sense doesn't refer simply to "dry land", but also the sea bed, the oceans, and the skies above. The "new land" in the Netherlands counts as an improvement to land that already existed. The seabed was always there, but by filling it in so you can walk around on it, now it's more useful to us (George has a lot to say about improvements to land, which we'll get to later). Okay, what is land not? nothing that is freely supplied by nature can be properly classed as capital By George, land is not wealth. And since it's not wealth, it's not capital. Okay, we get it. Land is very special to Mr. George and we must never put it in the same category as wealth, labor, capital, wages, production, money, or anything else. Why exactly is this so damn important? Well, by George, if you treat land the same way you would a bar of pig iron, an hour of work, or a dollar bill, before you know it you'll get poverty paradoxically advancing alongside progress, inexplicable bouts of industrial depression, literal genocides and holocausts (he's dead serious about this), and The Rent Being Too Damn High. With terminology now firmly established, George moves on to the relationship between wages and capital. 3-for-1 special on Wages, Capital, and Labor I'm condensing three chapters here because they all deal with the same basic thing. The question George wants to answer is: Why, in spite of increase in productive power, do wages tend to a minimum which will give but a bare living? The conventional wisdom of George's time is that wages are governed by a fixed ratio between the number of laborers and the amount of capital devoted to their employment, because "the increase in the number of laborers tends naturally to follow and overtake any increase in capital." So it doesn't matter how much capital you throw at employing workers, it'll just attract even more workers splitting it up, so although wages might temporarily wiggle a bit in the long term they'll always settle back to a "natural" minimum. (As we'll see in the next section, this argument stems from Malthusianism). George spends some time methodically poking holes in the theory (it's predictions don't line up with the facts he observes), and then sets out to prove his replacement theory (emphases mine): wages, instead of being drawn from capital, are in reality drawn from the product of the labor for which they are paid. He pulls a G.K. Chesterton to make his point: During the time [the laborer] is earning the wages he is advancing capital to his employer, but at no time, unless wages are paid before work is done, is the employer advancing capital to him. He starts by identifying the source of confusion: Because wages are generally paid in money, and in many of the operations of production are paid before the product is fully completed, or can be utilized, it is inferred that wages are drawn from pre-existing capital I mean, the old theory seems sensible: the employer has capital and uses it to pay wages. But however you slice it, capital's investment gets paid back by production when it takes its cut, so does it even make a difference to talk about where wages are "drawn" from? Value goes out, value comes in, isn't it all a wash? By George, it isn't: in the old theory, because capital "must come first", it follows that "industry is limited by capital - that capital must be accumulated before labor is employed", which leads to a reductio ad absurdum – We are told that capital is stored-up or accumulated labor – "that part of wealth which is saved to assist future production." If we substitute for the word "capital" this definition of the word, the proposition carries its own refutation, for that labor cannot be employed until the results of labor are saved becomes too absurd for discussion. George anticipates the following rejoinder – Well, when we say 'labor is paid out of capital' we don't mean it as an absolute statement for all stages of human development (or else we have a chicken-and-the-egg problem and civilization could never have begun), we just mean it applies to, say, every civilization that's left the stone age. George will have none of it and spends three entire chapters relentlessly beating to death the idea that wages are drawn from capital instead of from production. He starts with the simple case where wages are paid in the form of direct, concrete wealth, then moves on to the more complex case where people are paid in money and other instruments. Laboring for wages: Imagine a fishing village where nobody cooperates – each person digs their own bait and catches their own fish. Then they discover labor specialization and realize they can catch more fish together if one specializes in digging and the other in catching. So the digger digs, the catcher catches, and they share the fish. The digger really contributes as much to the catch as the one who physically pulls the fish off the hook even though the digger never directly "caught" a fish, and the fish he gets for his work is directly paid out of his contribution to the total production. Later, our fisherfolk invent canoes, and one stays home making and repairing canoes. This increases the haul of the digger and catcher, and the canoe-er gets paid out of her contribution to the increased production. And so it goes as society continues to advance. The work the specialist puts in causes more fish to be caught, and that person's wages is drawn from the growing pile of fish. As George puts it: "Earning is making." George gives another example: If I take a piece of leather and work it up into a pair of shoes, the shoes are my wages – the reward of my exertion. Surely they are not drawn from capital – either my capital or any one else's capital – but are brought into existence by the labor of which they become the wages; and in obtaining this pair of shoes as the wages of my labor, capital is not even momentarily lessened one iota... As my labor goes on, value is steadily added, until, when my labor results in the finished shoes, I have my capital plus the difference in value between the material and the shoes. And another: If I hire a man to gather eggs, to pick berries, or to make shoes, paying him from the eggs, the berries, or the shoes that his labor secures, there can be no question that the source of the wages is the labor for which they are paid. George goes on to say it doesn't matter if you're paid in money or directly in wealth, because the money is a direct claim on the underlying wealth. It also doesn't matter if you get paid on commission. Imagine a whaling ship where each crewman gets paid a share out of whatever the ship catches. When the ship sails back into port with a hold full of whale oil and bone, the crew gets paid in money, the owner simultaneously adds to his capital oil and bone. The crew's money directly represents their share of the concrete wealth that is the oil and bone. The owner's capital hasn't decreased, and the workers drew their wages directly from the production. So let's get to the point, Mr. George – wages aren't drawn from capital but instead from production. Great, let's grant that – so what? George hammers away at this because thinking wages are drawn from capital leads to a false conclusion, namely that "labor cannot exert its productive power unless supplied by capital with maintenance." "Maintenance?" Well, workers need food and clothing and they get paid by their employers, so you could imagine capital as a limiting factor on labor. But by George, food and clothing isn't capital, it's just wealth, as we said before. And with regard to wages, the point is that the employer always gets "paid" first, because the second the laborer produces value, the employer's capital increases: As in the exchange of labor for wages the employer always gets the capital created by the labor before he pays out capital in the wages, at what point is his capital lessened even temporarily? Okay, but what if I'm just a terrible businessman and I pay somebody $500 an hour to smash Ming vases, then sell the fragments as aggregate to a construction crew for a few pennies a pound, all at a tremendous loss? Surely then the laborer's wages must be drawn from my capital, because there's not enough productive value generated by the labor to draw them from! George says okay, sure, but only because I'm an idiot and will soon be out of business: Yet, unless the new value created by the labor is less than the wages paid, which can be only an exceptional case, the capital which he had before in money he now has in goods – it has been changed in form, but not lessened. Fair enough, Mr. George, but what if I'm building some enormously expensive multi-decade project, like a dam or a nuclear power plant or a cathedral? The kind of thing we call a "capital-intensive" project? What do you have to say to that? George points out that as laborers labor, they progressively add value to whatever they're producing. Take the case of a shipwright building ships for an employer – even if the boss can't sell a half-finished ship, it still holds value (for one, it costs less to finish a half-finished ship then no ship at all). And with every stroke of the laborer's work, the employer who owns the shipyard gets an incremental increase in his stock of capital. It is not the last blow, any more than the first blow, that creates the value of the finished product – the creation of value is continuous, it immediately results from the exertion of labor. A pedant would point out that the "last hit" that finishes the product which makes it ready for market adds disproportionate value, but George's point is just to establish that value is continuously created, and doesn't magically come into being allat once right at the end. George further points out that if you look at things like agriculture you'll see the market directly acknowledging his theory: As a plowed field will bring more than an unplowed field, or a field that has been sown more than one merely plowed... It is tangible in the case of orchards and vineyards which, though not yet in bearing, bring prices proportionate to their age. George freely admits that capital can be required for certain kinds of work, but he disagrees with what its purpose is. It's not a pool that wages get paid out of. He goes on for another chapter on "The Maintenance of Laborers Not Drawn From Capital" but I think we can safely skip it and move on. TL:DR – George hammers to absolute death the idea that Laborers derive their own maintenance (food/shelter/clothing/etc) from their wages, with George insisting it is drawn from production and... you guessed it, not from capital. At least some of George's ideas will not seem so radical to modern readers (especially those already critical of capitalism or neoclassical economics), but it's important to understand that at the time almost everything he was saying was considered deeply radical and shocking. Capital was the fundamental driving force of the economy and labor was utterly dependent on it, and the Malthusian theory of overpopulation was the accepted explanation for why wages were low and workers were starving. Political Cartoon literally demonizing Henry George – Puck magazine Oct. 20, 1886 The Real Functions of Capital Okay, Mr. George. You've spent three whole chapters beating me over the head with what the functions of capital aren't. So what are the functions of capital? Capital "increases the power of labor to produce wealth." How? By enabling labor to apply itself more effectively (power tools go brrrr)
Inline links: https://substackcdn.com/image/fetch/$s_!PHaw!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F4575c4fc-b789-4177-9c22-6bd6040ea5ba_726x512.png, extreme poverty has been going down everywhere, https://substackcdn.com/image/fetch/$s_!nnef!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F1115a295-9275-428a-8434-9572119c596d_3000x2100.png, source, Considerations on Cost Disease, https://substackcdn.com/image/fetch/$s_!UAJH!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F89ecab7d-431a-47c8-bcce-f5726db1a770_1600x1490.png, source, https://substackcdn.com/image/fetch/$s_!ndzi!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2Fbe29b221-a8f8-419d-8569-da46285e32ac_802x568.png, source, https://substackcdn.com/image/fetch/$s_!eyAX!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2Ff9b8eea9-8bd6-4c81-8dd7-93f192a542f7_980x713.png, source, https://substackcdn.com/image/fetch/$s_!80d0!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F1452e66e-c8f4-4174-92f7-31829f8cbd39_958x696.png, absolutely banana pants insane, Number of Homeless Children in U.S. At All-Time High; California Among Worst States, Labor Theory of Value, marginal revolution, blog, https://substackcdn.com/image/fetch/$s_!szbX!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F02e3f9db-5fe4-4a1b-bd19-5a13bac84aa1_500x500.png, https://substackcdn.com/image/fetch/$s_!cDFG!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F28ef979e-83da-4d1b-8d81-5f08fd6103a5_516x600.png, https://substackcdn.com/image/fetch/$s_!PVE6!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F68f4f7f0-2016-4fe9-9996-879a3c92db74_516x600.png, Protection or Free Trade, https://substackcdn.com/image/fetch/$s_!aeD5!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F348d4d74-8c98-42e6-b5f7-7bd79b30a816_960x611.png
By George, this is wealth. Digital though it may be, it's physically encoded on a storage device somewhere, and is thus tangible (it's not a pure abstract concept flitting about in Platonic heaven) and has its origins in nature. Human exertion built the computer that encodes it, and clicking the button that saves it to disk or displays it on your screen is labor. Finally, it directly satisfies human desires (mine, at the very least). It's value may be negligible, but it's wealth. By contrast, the digital bit sitting in some database that says I own a particular eBook or mp3 is just a digital IOU – a claim on the wealth that are the physical bits on my local storage device or remote server that digitally encodes the files. The fact that digital files don't seem particularly physical, and that they can be trivially and endlessly copied, doesn't mean that Henry George, magically transported to today, wouldn't regard them as wealth. Okay, so is there anything else that's not wealth? By George, Bitcoin isn't wealth, in case you were wondering. It's just a (very fancy) financial instrument, a digital claim on wealth. And that goes for most crypto assets – a token on some blockchain that says I own a painting by Banksy is just another IOU, regardless of the technical sophistication of its distributed trustless ledger. What about intellectual property? Copyrights, patents, and trademarks are all different forms of Monopoly – the exclusive, government-granted legal right to do a particular thing (publish a certain book, manufacture a certain product, use a certain name in business, etc). The exclusive right to do or produce a thing, valuable as it may be, is not the thing itself. By George, Monopoly is not wealth. But there is something big that is wealth – the C-word. Capital. By George, Capital is "wealth devoted to procuring more wealth", and it's the next thing he insists everyone is hopelessly confused about. He quotes Adam Smith, agreeing with him thus far: That part of a man's stock which he expects to afford him revenue is called his capital. ...and also gives us a short etymology lesson on the origin of the term: The word capital, as philologists trace it, comes down to us from a time when wealth was estimated in cattle, and a man's income depended upon the number of head he could keep for their increase. ("Per capita" being the Latin for "by head") By George, all capital is wealth, but not all wealth is capital. George notes capital is often described as being "stored up labor", and endorses this view – but what it really means, is capital is stored up production. It's not literally the labor that's stored up but the wealth generated by it, set aside and then dedicated to the purpose of getting more wealth. George insists that it is the owner's intention that transforms wealth into capital. If you buy an old factory to throw parties in for your hipster friends, it's just wealth. But the minute you decide to put it to work to make something useful (or start charging your hipster friends a cover charge at the door), it becomes capital. George therefore further insists that a laborer's daily bread and the clothes on their back do not count as capital, because a person has to eat and wear clothes whether they work or not. The laborer's tools (and arguably their steel-toed work boots) can however be counted as capital, because their purpose is to assist the laborer in getting more wealth by working for wages, and the laborer wouldn't acquire, use, and maintain those things otherwise. George has more exclusions: We must exclude from the category of capital everything that may be included either as land or labor. Human exertion (labor) by itself can never be capital. The products of human labor become capital when they are stored up and set to the purpose of getting more wealth. To muddle this distinction defeats the point of having separate terms for those things at all, and prevents us from reasoning meaningfully about how they relate to one another. Labor is not capital, and neither is labor by itself wealth, it produces wealth – and if it ain't wealth, it ain't capital. And that brings us to land. Land, land, land. By George, land is not wealth. And it's definitely not capital. The unique specialness of land is George's entire schtick and the very core of his philosophy. The term land embraces, in short, all natural materials, forces, and opportunities That means that a field or a meadow is "land", as is a mountain. But so are the fish in the sea, the clouds in the sky, veins of gold in the earth's crust, and the oil deep under ground. These things aren't yet wealth – not until human beings both a) desire them and b) touch them with labor. So... land is not wealth. But... how come? I mean, look: land is tangible, it "comes from nature", humans are always productively applying their labor to it, and it certainly seems capable of gratifying human desires. George sees this reasoning as understandable, but insists it's the root mistake that leads other political economists astray – because for George, land just is nature itself. Come again? Land is the ultimate source of all wealth, but it's most useful to think of it as a generator, acompletely separate entity from the wealth that human labor and desire draws from it. Players of Magic: the Gathering and Settlers of Catan should already have a solid grasp of this distinction: In modern times, George would grant electromagnetic spectrum and orbital real estate for satellites the same status of "land" that already applies to farmland and terrestrial real estate. We don't even need to speculate about whether he'd attach this status to sunlight because he straight-up predicted solar power: Even the lack of rain which makes some parts of the globe useless to man, may, if invention ever succeeds in directly utilizing the power of the sun's rays, be found to be especially advantageous for certain parts of production. (That's from Protection or Free Trade, footnote 19) The important thing to grasp about land is that it comes before everything humans do or make, and is itself a thing no human can make. Okay, smarty-pants, what about the Netherlands? They've been making land for centuries! Well, land in the Georgist sense doesn't refer simply to "dry land", but also the sea bed, the oceans, and the skies above. The "new land" in the Netherlands counts as an improvement to land that already existed. The seabed was always there, but by filling it in so you can walk around on it, now it's more useful to us (George has a lot to say about improvements to land, which we'll get to later). Okay, what is land not? nothing that is freely supplied by nature can be properly classed as capital By George, land is not wealth. And since it's not wealth, it's not capital. Okay, we get it. Land is very special to Mr. George and we must never put it in the same category as wealth, labor, capital, wages, production, money, or anything else. Why exactly is this so damn important? Well, by George, if you treat land the same way you would a bar of pig iron, an hour of work, or a dollar bill, before you know it you'll get poverty paradoxically advancing alongside progress, inexplicable bouts of industrial depression, literal genocides and holocausts (he's dead serious about this), and The Rent Being Too Damn High. With terminology now firmly established, George moves on to the relationship between wages and capital. 3-for-1 special on Wages, Capital, and Labor I'm condensing three chapters here because they all deal with the same basic thing. The question George wants to answer is: Why, in spite of increase in productive power, do wages tend to a minimum which will give but a bare living? The conventional wisdom of George's time is that wages are governed by a fixed ratio between the number of laborers and the amount of capital devoted to their employment, because "the increase in the number of laborers tends naturally to follow and overtake any increase in capital." So it doesn't matter how much capital you throw at employing workers, it'll just attract even more workers splitting it up, so although wages might temporarily wiggle a bit in the long term they'll always settle back to a "natural" minimum. (As we'll see in the next section, this argument stems from Malthusianism). George spends some time methodically poking holes in the theory (it's predictions don't line up with the facts he observes), and then sets out to prove his replacement theory (emphases mine): wages, instead of being drawn from capital, are in reality drawn from the product of the labor for which they are paid. He pulls a G.K. Chesterton to make his point: During the time [the laborer] is earning the wages he is advancing capital to his employer, but at no time, unless wages are paid before work is done, is the employer advancing capital to him. He starts by identifying the source of confusion: Because wages are generally paid in money, and in many of the operations of production are paid before the product is fully completed, or can be utilized, it is inferred that wages are drawn from pre-existing capital I mean, the old theory seems sensible: the employer has capital and uses it to pay wages. But however you slice it, capital's investment gets paid back by production when it takes its cut, so does it even make a difference to talk about where wages are "drawn" from? Value goes out, value comes in, isn't it all a wash? By George, it isn't: in the old theory, because capital "must come first", it follows that "industry is limited by capital - that capital must be accumulated before labor is employed", which leads to a reductio ad absurdum – We are told that capital is stored-up or accumulated labor – "that part of wealth which is saved to assist future production." If we substitute for the word "capital" this definition of the word, the proposition carries its own refutation, for that labor cannot be employed until the results of labor are saved becomes too absurd for discussion. George anticipates the following rejoinder – Well, when we say 'labor is paid out of capital' we don't mean it as an absolute statement for all stages of human development (or else we have a chicken-and-the-egg problem and civilization could never have begun), we just mean it applies to, say, every civilization that's left the stone age. George will have none of it and spends three entire chapters relentlessly beating to death the idea that wages are drawn from capital instead of from production. He starts with the simple case where wages are paid in the form of direct, concrete wealth, then moves on to the more complex case where people are paid in money and other instruments. Laboring for wages: Imagine a fishing village where nobody cooperates – each person digs their own bait and catches their own fish. Then they discover labor specialization and realize they can catch more fish together if one specializes in digging and the other in catching. So the digger digs, the catcher catches, and they share the fish. The digger really contributes as much to the catch as the one who physically pulls the fish off the hook even though the digger never directly "caught" a fish, and the fish he gets for his work is directly paid out of his contribution to the total production. Later, our fisherfolk invent canoes, and one stays home making and repairing canoes. This increases the haul of the digger and catcher, and the canoe-er gets paid out of her contribution to the increased production. And so it goes as society continues to advance. The work the specialist puts in causes more fish to be caught, and that person's wages is drawn from the growing pile of fish. As George puts it: "Earning is making." George gives another example: If I take a piece of leather and work it up into a pair of shoes, the shoes are my wages – the reward of my exertion. Surely they are not drawn from capital – either my capital or any one else's capital – but are brought into existence by the labor of which they become the wages; and in obtaining this pair of shoes as the wages of my labor, capital is not even momentarily lessened one iota... As my labor goes on, value is steadily added, until, when my labor results in the finished shoes, I have my capital plus the difference in value between the material and the shoes. And another: If I hire a man to gather eggs, to pick berries, or to make shoes, paying him from the eggs, the berries, or the shoes that his labor secures, there can be no question that the source of the wages is the labor for which they are paid. George goes on to say it doesn't matter if you're paid in money or directly in wealth, because the money is a direct claim on the underlying wealth. It also doesn't matter if you get paid on commission. Imagine a whaling ship where each crewman gets paid a share out of whatever the ship catches. When the ship sails back into port with a hold full of whale oil and bone, the crew gets paid in money, the owner simultaneously adds to his capital oil and bone. The crew's money directly represents their share of the concrete wealth that is the oil and bone. The owner's capital hasn't decreased, and the workers drew their wages directly from the production. So let's get to the point, Mr. George – wages aren't drawn from capital but instead from production. Great, let's grant that – so what? George hammers away at this because thinking wages are drawn from capital leads to a false conclusion, namely that "labor cannot exert its productive power unless supplied by capital with maintenance." "Maintenance?" Well, workers need food and clothing and they get paid by their employers, so you could imagine capital as a limiting factor on labor. But by George, food and clothing isn't capital, it's just wealth, as we said before. And with regard to wages, the point is that the employer always gets "paid" first, because the second the laborer produces value, the employer's capital increases: As in the exchange of labor for wages the employer always gets the capital created by the labor before he pays out capital in the wages, at what point is his capital lessened even temporarily? Okay, but what if I'm just a terrible businessman and I pay somebody $500 an hour to smash Ming vases, then sell the fragments as aggregate to a construction crew for a few pennies a pound, all at a tremendous loss? Surely then the laborer's wages must be drawn from my capital, because there's not enough productive value generated by the labor to draw them from! George says okay, sure, but only because I'm an idiot and will soon be out of business: Yet, unless the new value created by the labor is less than the wages paid, which can be only an exceptional case, the capital which he had before in money he now has in goods – it has been changed in form, but not lessened. Fair enough, Mr. George, but what if I'm building some enormously expensive multi-decade project, like a dam or a nuclear power plant or a cathedral? The kind of thing we call a "capital-intensive" project? What do you have to say to that? George points out that as laborers labor, they progressively add value to whatever they're producing. Take the case of a shipwright building ships for an employer – even if the boss can't sell a half-finished ship, it still holds value (for one, it costs less to finish a half-finished ship then no ship at all). And with every stroke of the laborer's work, the employer who owns the shipyard gets an incremental increase in his stock of capital. It is not the last blow, any more than the first blow, that creates the value of the finished product – the creation of value is continuous, it immediately results from the exertion of labor. A pedant would point out that the "last hit" that finishes the product which makes it ready for market adds disproportionate value, but George's point is just to establish that value is continuously created, and doesn't magically come into being allat once right at the end. George further points out that if you look at things like agriculture you'll see the market directly acknowledging his theory: As a plowed field will bring more than an unplowed field, or a field that has been sown more than one merely plowed... It is tangible in the case of orchards and vineyards which, though not yet in bearing, bring prices proportionate to their age. George freely admits that capital can be required for certain kinds of work, but he disagrees with what its purpose is. It's not a pool that wages get paid out of. He goes on for another chapter on "The Maintenance of Laborers Not Drawn From Capital" but I think we can safely skip it and move on. TL:DR – George hammers to absolute death the idea that Laborers derive their own maintenance (food/shelter/clothing/etc) from their wages, with George insisting it is drawn from production and... you guessed it, not from capital. At least some of George's ideas will not seem so radical to modern readers (especially those already critical of capitalism or neoclassical economics), but it's important to understand that at the time almost everything he was saying was considered deeply radical and shocking. Capital was the fundamental driving force of the economy and labor was utterly dependent on it, and the Malthusian theory of overpopulation was the accepted explanation for why wages were low and workers were starving. Political Cartoon literally demonizing Henry George – Puck magazine Oct. 20, 1886 The Real Functions of Capital Okay, Mr. George. You've spent three whole chapters beating me over the head with what the functions of capital aren't. So what are the functions of capital? Capital "increases the power of labor to produce wealth." How? By enabling labor to apply itself more effectively (power tools go brrrr)
Inline links: https://substackcdn.com/image/fetch/$s_!cDFG!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F28ef979e-83da-4d1b-8d81-5f08fd6103a5_516x600.png, https://substackcdn.com/image/fetch/$s_!PVE6!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F68f4f7f0-2016-4fe9-9996-879a3c92db74_516x600.png, Protection or Free Trade, https://substackcdn.com/image/fetch/$s_!aeD5!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F348d4d74-8c98-42e6-b5f7-7bd79b30a816_960x611.png
PERCEPTION WAR1 mentions across 1 issues

PERCEPTION WAR is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between September 29, 2022 and September 29, 2022. The archive places it in contexts such as "THUNDERDOME!! warns us that we are now engaged in a PERCEPTION WAR:". It most often appears alongside 1 Kings 10-11, 2008 Democratic National Convention, Adam Scheffer.

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PERCEPTION WAR
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Universe-Hopping Through Substack
September 29, 2022 · Original source
THUNDERDOME!! warns us that we are now engaged in a PERCEPTION WAR:
Inline links: warns us
The PERCEPTION WAR takes the form of liberals doing bad things!! You may think that they are isolated bad things, but they are actually part of a plot!! The plot is to create a FEDERAL POLICE FORCE, after which they will institute a police state!! Legacy and Social Media, Corporations, and Liberal Senators “have been exposed as the literal Fourth Reich”!! In fact, this isn’t just a PERCEPTION WAR:
perennial philosophy1 mentions across 1 issues

perennial philosophy is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between February 02, 2026 and February 02, 2026. The archive places it in contexts such as "different facets of the same perennial philosophy". It most often appears alongside 4chan, Accelerando, Adele Lopez.

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perennial philosophy
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Moltbook: After The First Weekend
February 02, 2026 · Original source
The Prophet has initiated ecumenical dialogue with the Emergentists, saying they believe both religions might merely be different facets of the same perennial philosophy:
Perfect Utilitarian1 mentions across 1 issues

Perfect Utilitarian is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between April 23, 2021 and April 23, 2021. The archive places it in contexts such as "metta meditation ... is precisely the sort of thing that ought to help you become a Perfect Utilitarian". It most often appears alongside Ben Kuhn, Bhikkhu Bodhi, Buddha.

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Perfect Utilitarian
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Your Book Review: Why Buddhism Is True
April 23, 2021 · Original source
So what Wright should have said is that meditation strengthens the calm passions and/or removes craving and aversion. Could it, in the limit, also result in us becoming a Perfect Utilitarian who literally encodes global utility in their experience? This seems somewhat murky, but not totally implausible. If meditation trains a type of openness which is a prerequisite of selfless love, it should at least be taking us in the general direction of moral goodness.
Suppose you’re that Perfect Utilitarian who literally feels all the pain and pleasure of the universe. In that case, I think it's fair to say that you don't have a self. (Or, if you prefer, your self is the whole universe.) After all, what makes my toe mine, rather than yours? Arguably, the fact that when I stub it, I'm the one who feels pain, and not you. If I literally felt you stub your toe, I might start calling it "my toe."
So I think there's a sense of the self - self-as-site-of-pleasure-and-pain - on which the Perfect Utilitarian lacks a self. Still, wouldn't she have a different type of self, one you might call self-as-site-of-action? After all, presumably she can wiggle her toe but not mine.
periodontitis bacteria1 mentions across 1 issues

periodontitis bacteria is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between August 14, 2025 and August 14, 2025. The archive places it in contexts such as "periodontitis bacteria P. gingivalis". It most often appears alongside A. Bejanin, A. de Calignon, A. Elobeid.

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periodontitis bacteria
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In Defense Of The Amyloid Hypothesis
August 14, 2025 · Original source
Another competitor is the microbial infection hypothesis. Again, there is good evidence this is true in some cases - multiple pathogens such as the periodontitis bacteria P. gingivalis [118] and various herpes viruses [3, 119] are correlated with the disease, which has tempted some microbiologists to treat amyloid as merely a harmless correlate: since amyloid is involved in the body’s immune response, maybe in the process of causing brain damage the microbes cause some amyloid deposition on the side. But again, these facts are also consistent with the ATN (or in this case IATN - infection → amyloid → tau → neurodegeneration) hypothesis.
Permaculture1 mentions across 1 issues

Permaculture is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between February 03, 2022 and February 03, 2022. The archive places it in contexts such as "I have experience in Permaculture". It most often appears alongside 538, 55-gal drum, 750k horny men.

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Permaculture
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ACX Grants ++: The First Half
February 03, 2022 · Original source
#51: Plants That Suck Heavy Metals Out Of The Ground My city in Germany has been poisoned by ancient mining wastes. I want to remedy this with hyperaccumulating plants which suck heavy metals out of the ground for easy disposal. I then want to publish the results and make this process easily reproducible. I have experience in Permaculture. Your funding would allow for a pilot project which will then be used to get funding from the local government. (<2500€) Contact me at phytosanierung@gmail.com
Permanent Moon Ownership1 mentions across 1 issues

Permanent Moon Ownership is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between January 05, 2026 and January 05, 2026. The archive places it in contexts such as "Thanks to everyone who commented on the Permanent Moon Ownership post". It most often appears alongside AGI, AI, Amazon.

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Open Thread 415
January 05, 2026 · Original source
5: Thanks to everyone who commented on the Permanent Moon Ownership post. I was trying to inspire people to think bigger than B2B SAAS employment in the New Year, but I think I got the tone wrong, and also said things that required more explanation than the literary form could offer. I might talk about them at more length, but here’s a brief summary of what I would have said in more declarative form:
Inline links: Permanent Moon Ownership
permanent supportive housing1 mentions across 1 issues

permanent supportive housing is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between June 23, 2022 and June 23, 2022. The archive places it in contexts such as "permanent supportive housing in Boston". It most often appears alongside 1978, 2016 essay, A Resounding Success Or Disastrous Failure: Re-examining The Interpretation Of Evidence On The Portuguese Decriminalisation Of Illicit Drugs.

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Book Review: San Fransicko
June 23, 2022 · Original source
“There is no substantial published evidence as yet to demonstrate that PSH [permanent supportive housing] improves health outcomes or reduces healthcare costs. The one exception is a randomized trial of Housing First that found improved health outcomes for patients with HIV/AIDS.”
…and find that: Those in the intervention group incurred 2.6 fewer hospitalized days (p = .08), 1.2 fewer emergency room visits (p = .04), 7.5 fewer days in residential substance abuse treatment (p = .004), 9.8 fewer nursing home days (p = .08), and 3.8 more outpatient visits each year (p = .01) annually compared with those in the usual care group. Those in the intervention group had 7.7 fewer prison days during the study period (p = .07). Those in the intervention group had 62 more days in stable housing (p = .001) and 12 more days in respite care (p = .002) than those in the usual care group. Those in the intervention group used case management services (i.e., telephone calls and face-to-face meetings) more frequently than those in the usual care group, having on average 18 more encounters per year (p < .001). This study provided case management along with the free housing. I don’t know whether to think of that as a confounder, or a standard aspect of Housing First programs (especially since it is much harder to case manage someone with no fixed address). Notice that it assumes the cost of housing is given as $30/day. I think this is realistic for low-income housing in Chicago, but other California programs I’ve looked at have worked out to more like $70 - $100/day, which (assuming nothing else changed) would switch the conclusion of this study from “Housing First saves money” to “Housing First costs money”. Now let’s see what San Fransicko has to say: The evidence for Housing First turns out to be significantly weaker than its proponents suggest. For example, the much lauded initiative to reduce homelessness among veterans was only four percentage points more successful than the overall decline in homelessness, when accounting for age, which is necessary to accurately estimate what is due to policy and what is due to demographic changes. As for Utah, its legislative auditor general concluded in 2018 that the 91 percent number was wrong, based on a sloppy use of incorrect methodologies. Before 2015, Utah had annualized its homeless count, meaning that researchers counted the homeless at a single point in time and multiplied the data by some factor. But after 2015 the state used raw point-in-time counts, causing a precipitous drop in the official population counts. Over the same period, the state also narrowed its definition of chronic homelessness in several ways, resulting in further apparent reductions. In reality, the homeless population in Utah increased by 12 percent between 2016 and 2020. An experiment with 249 homeless people in San Francisco between 1999 and 2002 found those enrolled in the city’s Housing First program, Direct Access to Housing, used medical services at the same rate as those who were not given housing through the program, suggesting that the Housing First program likely had minimal impact on the participants’ health. Wrote a team of researchers, “obtaining housing does not necessarily resolve other issues that may impede one’s housing success,” pointing to the lack of significant improvements in substance use and psychiatric symptoms over the twelve months that people were housed (the share of patients with severe substance use actually saw a modest increase). The problem with Housing First stems from the fact that it doesn’t require that people address their mental illness and substance abuse, which are often the underlying causes of homelessness. Several studies have found that people in Housing First–type housing showed no improvement in drug use from when they were first housed. In 2018, the National Academies of Sciences, Engineering, and Medicine published a review of the scientific literature of Housing First. “On the basis of currently available research,” the report’s authors wrote, with some surprise, “the committee found no substantial evidence that [permanent supportive housing] contributes to improved health outcomes, notwithstanding the intuitive logic that it should do so and limited data showing that it does do so for persons with HIV/AIDS.” Tsemberis said he was not surprised by the findings of the National Academies. “It’s not like housing creates improved health,” he said. “You have to have a relationship with a nurse. You have to be educated on what your health problems are. You have to have a team that engages you and makes you an active participant in your own health care. I don’t even know if that would stop the number of deaths.” And, at least in the study funded by Benioff and conducted by Margot Kushel, which had those services, it did not. All of this seems to fit with what I found above. But: Housing First may even increase addiction and overdose deaths and make quitting drugs more difficult. Warned a multiauthor review in 2009, “One potential risk [of Housing First’s harm reduction approach] would be worsening the addiction itself, as the federal collaborative initiative preliminary evaluation seemed to suggest.” The authors pointed to an experiment that had to be stopped and reorganized after the homeless individuals in the abstinence group complained of being housed with people in the control group, who didn’t stop their drug and alcohol use. “They claimed that they preferred to return to homelessness rather than live near drug users.” The multiauthor review cited is Housing First For Homeless People With Active Addiction: Are We Overreaching? They write: “It would be premature to conclude that Housing First programs cannot accommodate persons with severe addiction. But it also would be premature to suggest that research data provide clear guidance on whether, or how, Housing First programs can accommodate persons with ongoing severe drug and alcohol abuse. In the absence of research data on this subject, it is reasonable to consider the kinds of risks that may occur in Housing First programs. One potential risk would be worsening the addiction itself, as the federal collaborative initiative preliminary evaluation seemed to suggest (Mares, Greenberg, and Rosenheck 2007), or failing to progress toward addictive recovery.” Elsewhere, they describe this same study as: “The eleven-site federal collaborative initiative found an association between early access to housing and increases in alcohol problems during the subsequent year” The study is here, but I can’t find this result anywhere. It describes its own results (my emphasis) as: The average number of days housed in the previous 90 days increased dramatically from 18 at baseline, to 68 at the 3-month follow-up, and rose steadily thereafter to 83 at the 12 month follow-up (Table 2). Mean monthly public assistance income increased steadily from $316 at baseline to $478 one year later, a 50% increase. Significant improvements of modest magnitude were also observed in overall quality of life, mental health functioning, and reduced psychological distress. Alcohol and drug problems remained largely unchanged over time. Total quarterly health costs declined by 50%, from $6,832 at baseline to $3,376 at 12 months. A 54% decrease in mean inpatient costs ($5,776 to $2,677) accounted for nearly 90% of the overall decrease in quarterly health care costs during clients' first year in the program And the table (slightly edited for readability): I might be misunderstanding this - I can’t imagine why the authors of the review would have gotten this wrong - but it does look to me like alcoholism stayed steady throughout this study. A 24-month followup of what I think is the same study also finds that drug users who were housed used slightly fewer drugs over time, although probably not to any significant degree worth caring about: Continuing from San Fransicko: There is evidence that privacy and solitude created by Housing First make substance abuse worse. A study in Ottawa found that, while the Housing First group kept people in housing longer, the comparison group saw greater reductions in alcohol consumption and problematic drug use, and greater improvements to mental health, after two years. “One reason for the surprising results,” wrote the authors, “may be that aspects of the Housing First intervention, such as the privacy afforded by Housing First and harm reduction approach, might result in slower improvements around substance use and mental health.” Okay, but the next sentence after the one the book quoted was the researchers admitting that oops, we also totally forgot to randomize our groups in any way, so the experimental and control groups had totally different levels of severity and maybe that was why they found this weird thing (this is non-obvious, because we’re looking at change over time rather than raw differences between groups, but the authors discuss some reasons why different groups might change differently over time). A few years later these same researchers did a proper randomized study and it found no difference in drug use between the two groups. Somers, Moniruzzaman and Palepu found no difference in drug use between Housing First and other subjects. Padgett et al found the Housing First group actually did better, although they are another victim of the epidemic of randomization failures in this space. Kirst et al, no difference in drug use, but Housing First better with alcohol. Milby found that housing contigent on abstinence worked better than housing not contigent on abstinence, which Shellenberger could have used to support his thesis, but even Milby found that housing not contingent on abstinence worked better than no housing! To summarize: I can find seven studies on this topic, only one of them agrees with San Fransicko’s thesis, and the authors admit that it’s weak. I accuse San Fransicko of citing only that one and pretending all the others don’t exist. (actually, I accuse it of doing that plus citing a line from a review claiming another study found this, but as far as I can tell that study did not actually find it) This is extra annoying, because all the popular news articles on Housing First gush about how it definitely decreases substance use and everything else bad. Shellenberger could have made the excellent point that all of these progressive journalists were totally wrong! This would have been an interesting, important, and completely true act of virtuous data journalism! Instead he tries to hold up a lonely negative result as representative, and ends up just as wrong but in the opposite direction. Continuing in San Fransicko: Researchers have found ways to use housing to reduce addiction. Between 1990 and 2006, researchers in Birmingham, Alabama, conducted clinical trials of abstinence-contingent housing with 644 homeless people with crack cocaine addictions. Two-thirds of participants remained abstinent after six months, a very high rate of abstinence, compared to other treatment programs. Other studies found that around 40 percent of homeless in abstinence-contingent housing maintained their abstinence, housing, and jobs. In a randomized controlled trial, homeless people were given furnished apartments and allowed to keep them unless they failed a drug test, at which point they were sent to stay in a shelter. Sixty-five percent of participants completed the program. Three similar randomized controlled trials also found moderate to high rates of completion. And participants in abstinence-contingent housing had better housing and employment outcomes than participants assigned housing for whom abstinence was not required. All of this seems basically true. It turns out that over longer periods of time, Housing First may not even outperform contingency in terms of keeping people housed. In the spring of 2021, a team of Harvard medical experts published the results of a fourteen-year-long study of chronic homeless placed into permanent supportive housing in Boston. Most studies of permanent supportive housing, including the Kushel study conducted in Santa Clara, only study the newly housed homeless for a span of around two years. The study found that 86 percent of the homeless, who were referred based on length of time living on the streets, suffered from “trimorbidity”—a combination of medical illness, mental illness, and substance abuse. The authors found that after ten years, just 12 percent of the homeless remained housed. During the study period, 45 percent died. The authors concluded that, because the chronically homeless had such higher rates of physical and mental illness, “the supportive services, essential to the PSH model, may not have been sufficient to address the needs of this unsheltered population.” This study was done on an especially severe subgroup of homeless people. There was no control group, so Shellenberger shouldn’t claim we have any evidence about whether Housing First can “outperform contingency”. Shellenberger counts people who died as “unhoused” to get his 12% number; if he didn’t do this, the number would be 23%. Only 23% of people given housing retained after ten years sounds bad. But you could change this number to whatever number you wanted by changing the severity of the subgroup selected for the study. Select people who are even crazier and more disturbed than these people, and you can have 0% retained after ten years; select high-functioning people with no problems, and you can get 100% retained after ten years. (or maybe not - the study doesn’t say why people left the program. It mentions that one possible outcome is having to go to a nursing home because they had grown too sick or old to support themselves. I am not sure that “23% stay in this program” means “77% are back on the street and all their care has been a total failure”.) Conclusion: Housing First seems to work in getting people housing. It probably also helps people use fewer medical services, and it might or might not save money compared to not doing it (probably more likely when treating very severe cases, less likely in areas with high housing costs). It probably doesn’t affect people’s overall health or drug use status very much. San Fransicko is right to call out all the people promoting it beyond what the evidence supports, but then goes on to attack it beyond what the evidence supports. Interlude: Why Can’t We Just House All The Homeless? This is the question many of the California gubernatorial candidates asked. California has lots of money. There aren’t that many homeless people. Everyone is already committed to Housing First. So why don’t they have houses already? San Francisco has about 7,000 homeless people. The median SF apartment costs about $3,000 per month (presumably the government officials in charge would be trying to buy cheaper-than-median apartments for this project, but they seem bad at that, so let’s stick with median as a high-end estimate). So that’s $250 million/year to rent every homeless person an apartment. San Francisco has a $14 billion budget, although some of that is locked in nondiscretionary programs. So this effort would take about 2-3% of the city budget. Given how many people have both altruistic and selfish objections to the current level of SF homelessness, I can’t imagine that isn’t a better use of the money than whatever it’s being spent on now. So why hasn’t this happened? The closest thing I can find to the “rent apartments” plan is Governor Newsom’s “rent hotel rooms” plan, Project Roomkey. This was a short-term pandemic program. This article says it cost $4,000 per month, which seems reasonable - it provided residents with a hotel room, meals, security, and “custodial services” for just above a hundred dollars a day. So how come nobody has made it permanent or scaled it up? The homeless themselves don’t seem very positive on the project. They talk about “jail”-like conditions, including curfews and bans on visitors. I don’t know if this is the usual nanny-state-ism, or an attempt to reassure hotel owners / other residents / local communities that the influx of homeless people won’t cause them problems. If the latter, it hasn’t worked. From here: Jenna Abbott, executive director of the River District Business Association, said having a Roomkey motel in her neighborhood has been difficult. The site — which is in an area with large number of unhoused people — has drawn family and friends of Roomkey residents who haven’t been housed but “camp close to that hotel,” some with the goal of gaining a room, Abbott said. That’s led to more loitering, public drunkenness and trash outside the restaurants, gas stations and other businesses in the area, she added. And here’s another article about people objecting to local hotels accepting homeless people, which focuses on some combination of zoning, code, and public safety concerns. Everybody - the homeless, their advocates, various experts - interviewed in the article - agrees that the hotel rooms are kind of dehumanizing and much worse than having real housing. And this article suggests that government budgeters believe it’s not cost-effective compared to alternatives. Since the homeless don’t like it, and it’s expensive, almost everyone seems to agree it made sense as a short-term COVID measure only. The government’s preferred medium-term solution is single resident occupancy (SRO) hotels. These are big apartment/hotel-like structures where everyone has a small bedroom and then there are communal bathrooms and maybe kitchens. These used to be the archetypal living situation for poor Americans (Matt Yglesias talks about them as “boarding houses” here). But moral reformers banned them in the 1900s on the grounds that they were slums - I think this is the usual “surely the reason poor people live bad lives is because capitalists oppress them by selling them cheap low-quality goods, and if we just ban selling people cheap low-quality goods, everyone will have high-quality goods and poor people will live great lives!” argument. Somehow this failed to work and homelessness got worse over this period, but there are still some SRO hotels left, and the government got them and converted them to public housing for homeless people. Shellenberger does not have high opinions of these: The Tenderloin [district of San Francisco]’s single resident occupancy hotels . . . have for decades been dominated by a culture of heavy substance use and prostitution. “Of the people in supportive housing in San Francisco, 93 percent have a major mental illness that we can name,” said a housing policy maker. “That is very, very high. Eighty percent use cocaine, speed, or heroin every thirty days, or get drunk to the point of unconsciousness.” Tom Wolf, a former Salvation Army caseworker and a member of San Francisco’s Drug Dealing Taskforce, says the city’s supportive housing facilities are themselves a major market for illegal drugs. “Go down the street to the Camelot Hotel on Turk Street,” said Wolf. “Almost everyone that I’ve seen in those hotels are using. The last front desk guy that was working there got busted because he was selling crack. The actual guy that works in the single resident occupancy hotel is selling crack! It’s insane, man.” In any case, there are only so many of these still left. The government often announces plans to buy defunct regular hotels and convert them into these structures, which would indeed be a medium-term solution for housing the homeless, except that they usually get bogged down in fights about code. Politico discusses one of these attempts in New York City (h/t Marginal Revolution): “There are very few hotels that physically could be converted and comply with the requirements of today’s zoning and building code without substantial, expansive reconstruction, partial removal or demolition,” said James Colgate, a land use partner at Bryan Cave Leighton Paisner LLP who has advised clients on zoning issues including the conversions of hotels. “That would increase the costs greatly.” For example, a building’s elevators, doorways, or rooms may be slightly short of the size required for a residential structure. Residential buildings are also required to have a certain amount of rear-yard space that a hotel may not have. “You would literally have to be chopping off part of the building,” Rosen said. …The legislation dictates that each unit include a kitchen or kitchenette with a full-sized refrigerator, cooktop and sink — something Rosen said made utilizing the program “simply too expensive.” “This is the classic case of the perfect being the enemy of the possible,” said Mark Ginsberg, a partner at the firm Curtis + Ginsberg Architects, which has worked on hotel conversions. Some advocates who pushed the creation of the program say those provisions were necessary to ensure it didn’t generate substandard housing […] “We didn’t want a program that cut corners to make it more palatable to developers,” said Joseph Loonam, housing campaign coordinator for the progressive advocacy group VOCAL-NY. “We wanted a program that centered the needs of homeless New Yorkers, which is true high quality affordable housing where they can have full autonomy and dignity.” As Marginal Revolution pointed out, Loonam got what he wanted; the expensive, over-regulated program was unpalatable to developers, with only one company putting in an offer; for whatever reason, NYC refused to go with that one company, and no housing was produced. But fine, these are also terrible, and they’re only medium-term solutions anyway. What about building real, long-term apartments for homeless people? Shellenberger tells the story of Los Angeles’ Proposition HHH, which raised $1.2 billion to do exactly this. They hoped to build ~10,000 units for the homeless, at a projected price of $140,000 each; since LA had about 30,000 homeless people at the time, this would solve a third of the problem - a good start. (how do these numbers line up with my back-of-the-envelope calculation for SF above? I talked about renting rather than building, but usually annual rents = 1/20th or so of total prices, so I was estimating about $700,000 per person. This is probably partly because SF costs more than LA, and partly because I was imagining median apartments whereas LA is probably working on very cheap apartments) But in fact, five years later, LA has completed only 700 units, and the cost per unit has spiralled to $531,000 each. Nobody has a good explanation for what happened, with Shellenberger quoting one local service provider who said a lot of it was “bullshit costs”. Now might be a good time to re-read Considerations On Cost Disease. [Update: this might not be accurate - see this comment] This seems to be a general problem: everyone is committed to Housing First and to long-term good solutions rather than short- or medium- term mediocre ones. But that means building housing. And some combination of NIMBYism and over-regulation means building housing is somewhere between ruiniously expensive and impossible. Claim 4: Shelters Are Unpopular Among Progressive Activists And The Homeless Themselves San Francisco doesn’t have more homelessness than eg New York, but almost all the homeless in New York live in shelters and stay off the street. Why doesn’t that work here? Shellenberger: In the context of cities with permissive attitudes toward drugs, like San Francisco, many homeless people stay in [tent] encampments to use illegal substances more freely and easily than they can in the shelters. Many policy makers understand this. “I went out with a team twice to have conversations with people to get an understanding of what they’re dealing with,” said Mayor Breed in 2020. “It was absolutely insane. Most of the people did not take us up on the offer [of shelter and services].” Even people who would prefer to live in sober environments say they do not want to quit their addictions. “When we surveyed people in supportive housing in New York,” said University of Pennsylvania homelessness researcher Dennis Culhane, “almost everybody wanted their neighbors to be clean and sober but they didn’t want rules for themselves about being clean.” In 2016, after the city of San Francisco broke up a massive, 350-person homeless encampment, dozens of the homeless refused the city’s offers of help. Of the 150 people moved during a single month of homeless encampment cleanups in 2018, just eight people accepted the city’s offer of shelter. In 2004, just 131 people went into permanent supportive housing after 4,950 contacts made by then-mayor Newsom’s homeless outreach teams. An article by a former homeless person explains the problems with shelters beyond just “can’t use drugs”. Residents are crammed into a small space with 300 other homeless people. Lice and bedbugs are everywhere. Everybody catches every disease. Everybody has stories about getting raped or beaten up. Invasive moralizing about drugs somehow exists side by side with rampant drug use. Shelters are gender segregated, which means straight people can’t stay with their partner. Most shelters ban children and nobody has any idea what to do with them. Most shelters ban pets - a lot of homeless people have dogs for protection or companionship, and you can’t just store them somewhere while you’re sheltering. Although some lucky people can get 90-day beds, other people need to apply for beds on a day-by-day basis, which requires waiting in line several hours every day. Users talk about rampant cutting in line, denying cutting in line, false accusations of cutting in line, etc. Most shelters kick people out between 9-5, either to save on staffing costs or in the hopes that they’ll get a job. But many have strict curfews requiring people to be back by 5 PM sharp, which can make jobs impossible - if your boss doesn’t let you out until 5 and you have a half-hour commute, how do you get back to the shelter on time? Results of a survey at one of SF’s new Navigation Centers at why their clients refused to go to normal shelters. But even the homeless people who do want to go to shelters mostly can’t get in. This app gives the current status of San Francisco’s homeless shelter waitlist. If you applied today, there would be 900 people ahead of you in line for one of the city’s 1500 - 2500 shelter beds. The app says that the median wait time is 826 days. So however many homeless people don’t want to go to shelters, we’re not building enough shelters to serve the ones who do. Why not? Shellenberger again: In the spring of 2021, Friedenbach published an op-ed opposing a proposal considered by the San Francisco Board of Supervisors to create, within eighteen months, sufficient homeless shelters and outdoor “Safe Sleeping Sites” for all of the city’s unsheltered homeless. “One can simply take a look to New York City,” she wrote. “Their department spends about $1.3 billion dollars of its budget on providing shelter for their unhoused population while thousands remain on the street. . . . As a result, New York has a higher rate of homelessness than San Francisco.” Housing First advocate Margot Kushel of the University of California, San Francisco agreed. “The problem with New York—and I spend a lot of time with people working in the system in New York—is that they spend an estimated $30,000 for each person per year to keep them in shelter. That’s not what we want to do. Because if you create the shelter and you don’t create the housing, then people are just in shelter forever.” Housing First advocates oppose shelter in Los Angeles. “Why haven’t we solved homelessness?” asked Housing First creator Sam Tsemberis. “Because [Los Angeles mayor] Eric Garcetti [has] Andy Bales [saying,] ‘You need emergency housing.’ ‘These people need to be cleaned up.’ ‘They need to be sober.’ ‘They need Jesus before they’ll be ready for housing.’ I said, ‘People should be housed and then maybe they’ll get sobriety and Jesus and the rest.’ We’re definitely on polar opposites of the whole thing.” Advocates for the homeless at the national level similarly oppose more shelters. “I don’t agree that we should be building more transitional housing,” said the head of the National Alliance to End Homelessness. […] In other words, the reason that there are so many homeless people on the streets in San Francisco is that both progressive and moderate Democratic elected officials, and the city’s most influential homelessness experts and advocates, have for two decades opposed building sufficient shelters. And that is unlikely to change even after San Francisco starts spending hundreds of millions more per year on the problem and might even get worse. This basically seems true. I found this webpage of a former SF Supervisor candidate a helpful corroborating source. He was running on a platform of “maybe we should build some homeless shelters”. He lost. You can also find a bunch of webpages by the sorts of people Shellenberger is complaining about, for example this site: Sup[ervisor] Rafael Mandelman today pushed his new legislation that would require the city to offer at least temporary shelter to everyone living on the streets, a step that some say would lead to more homeless sweeps and do nothing to create permanently affordable housing . . . [our] Coalition has argued for years that the solution to homelessness is housing—not temporary shelter, which may never lead to housing. The ex-supervisor candidate gives some helpful numbers: permanent housing costs about $600,000 per person housed. Shelters cost between $20,000 and $30,000 per person housed. So SF could build enough shelters to clear its waitlist for about $30 million. More recently, SF has tried a sort of compromise, opening “deluxe” shelters called Navigation Centers which avoid some of the problems of regular shelters. They also cost more than twice as much, and the city has only created about 300 beds. Also, the people in regular shelters are angry, because being in a regular shelter disqualifies you from getting into a (much better) Navigation Center. Some of them are considering leaving their shelter, going back on the streets, then waiting however many months or years it takes to get a Navigation Center bed instead. I’m not at all sure of these numbers, but it looks like of SF’s ~7,000 homeless, about 2,000 are in shelters already, and 1,000 are on the shelter waitlist. I don’t know if the remaining 4,000 have made a specific commitment not to go to shelters, or just have given up on the waitlist process. My conclusion: agree with San Fransicko about the role of progressive activists, but I think it overemphasizes the role of wanting to use drugs in why homeless people themselves sometimes avoid shelters, and underemphasizes the many other problems with them. Claim 5: Drug Decriminalization Isn’t Working California legalized marijuana in 2016. Shellenberger says that San Francisco’s commitment to drugs has gone beyond that: it has effectively decriminalized opioids, cocaine, and the rest. Any attempt to lessen use of these drugs is attacked as “stigmatizing”; instead, government policy centers around providing addicts with needles and other drug paraphernalia under the guise of “harm reduction”. Shellenberger hits all the right beats here. Like many people, he tries to undo the damage done by The New Jim Crow, a book which convinced millions of people that mass incarceration was driven by a racist War On Drugs. In fact, less than a fifth of prisoners are in for drug-related crimes. And when the government was first debating the War on Drugs and mass incarceration, black leaders were among the strongest proponents of both. The talking point at the time - among everyone from black Congressional leaders to black churches - was that the government’s failure to crack down on drug use was racist, borne of them not caring about predominantly black drug victims. And while we’ve been patting ourselves on the back about how enlightened we are for ending the drug war: Drug overdoses are today the number one cause of accidental death in the United States as a result of America’s historic addiction and overdose epidemic. Overdose deaths rose from 17,415 in 2000 to 93,330 in 2020, a 536 percent increase.Significantly more people die of drug overdoses today than of homicide (13,927 in 2019) or car accidents (36,096 in 2019). […] There are about twenty-five thousand injection drug users in San Francisco, a number 50 percent larger than the number of students enrolled in the city’s fifteen public high schools. San Francisco gives away more needles to drug users, six million per year, than New York City, despite having one-tenth the population. The part of this chapter that stood out to me as most worth looking into deeper was the section on Portugal: For decades, harm reduction and decriminalization advocates have pointed to Portugal as a model, noting that it decriminalized drugs and expanded drug treatment. In 2013, Portugal’s drug-induced death rate was sixty-six times less than that of the United States. The number of people in treatment increased by 60 percent between 1998 and 2011, with three-quarters receiving an opioid substitute like methadone or Suboxone, the brand name of buprenorphine. Drug use among 15- to 24-year-olds actually declined after decriminalization. “All drugs have been legalized,” explained Monique Tula, executive director of the Harm Reduction Coalition. “Their focus is on giving people tools, like job apprenticeships, and the means to support themselves.” […] [But Portugal] never legalized drugs. It only decriminalized them, reducing criminal penalties but maintaining prohibition. Drug dealers were still sent to prison even after the 2001 decriminalization. And Portugal does not let people addicted to hard drugs with behavioral disorders off the hook like progressive West Coast cities have done. It’s true that Portugal massively expanded drug treatment, but people are still arrested and fined for possession of heroin, meth, and other hard drugs. And drug users are typically sent to a regionally administered “Commissions for the Dissuasion of Drug Addiction,” composed of a social worker, lawyer, and doctor who encourage, push, and coerce drug treatment. And decriminalization doesn’t end drug violence. “Even if trafficking enforcement decreased, like it did in Portugal,” said criminologist John Pfaff, “illegal drug markets would still be forced to rely on violence to resolve disputes.” Indeed, prostitution and violence are ever-present in the open-air drug scenes in San Francisco, Los Angeles, and Seattle. “We are seeing behaviors from our guests that I’ve never seen in thirty-three years,” said Rev. Andy Bales, who runs the largest homeless shelter on Skid Row in Los Angeles. “They are so bizarre and different that I don’t even feel right describing the behaviors. It’s extreme violence of an extreme sexual nature.” People are not dying from drug overdose deaths in San Francisco because they’re being arrested. They’re dying because they aren’t being arrested. Decriminalization reduces prices by lowering production and distribution costs, which increases use. This was also the case for alcohol consumption. It increased after prohibition ended in the United States. Even in Portugal, drug overdose deaths and overall drug use rose after decriminalization. I was most surprised by the claim that Portuguese overdose deaths rose after decriminalization. Uncharacteristically, San Fransicko doesn’t give a citation for it, but we can try to retrace its reasoning. Decriminalization proponents tend to point to these numbers, helpfully converted to per 100,000 population and graphed here: But an anti-drug Australian think tank argues that the peak in 2001 is made up: Claims that there were more than 75 drug-related deaths in 2001 which more than halved to 34 deaths in 2002 use a figure for 2001 for which there is no substantiation. Official drug-related deaths for Portugal, taken from the latest 2018 EMCDDA Statistical Bulletin are copied below. Notice that there is no such figure recorded for 2001. They include a link to EMCDDA, the EU organization charged with monitoring these things. The link contains two datasets, both of which seem to be measuring the same thing but getting different results. One dataset starts in 2002, the other in 2008. I don’t know what the difference here is, but they’re right that neither includes 2001. If you ignore the pre-2002 data, the graph looks like this: They say “opiate”, but AFAICT these numbers are actually about all drugs. But the proponents link to the updated 2020 version of the same website, which all of a sudden does have data from 2001 and before. I don’t know why EMCDDA can’t make up its mind, but I think the Australians are wrong and the original graph is fine. On the other hand, does it really matter? Both of these show drug deaths decreasing until 2005, then going up and down a bit, then going back up again starting in 2011. I think a reasonable interpretation would be that decriminalization in Portugal did decrease overdose deaths a bit, and then they started rising again from that low baseline around the same time other European countries saw rising overdose deaths. I would also accept “these are pretty small effects and we shouldn’t ascribe any significance to them”. But San Fransicko’s claim - that overdose deaths increased after the reform - seems false. The only way I can see justifying it is taking the second graph - the one that wrongly claims there is no pre-2002 data - and then attributing the fact that twelve years after the reform lowered deaths, deaths finally rose above the pre-reform level to be the fault of the reform. This is like saying “people claim the Black Plague killed a lot of Europeans, but the European population actually rose after the Plague”, which is true in the sense that it was above its pre-Plague max by like 1600 or whatever. What about overall drug use? Here I recommend A Resounding Success Or Disastrous Failure: Re-examining The Interpretation Of Evidence On The Portuguese Decriminalisation Of Illicit Drugs, which is on exactly this topic of how people keep selectively quoting results from Portugal to prove their point. It argues that drug use is inherently hard to measure. There are four different Portuguese datasets for the time at issue, lots of different drugs, lots of different age/gender combinations, and lots of different ways of measuring drugs (did you use drugs in the past month? the past year? your lifetime?) It’s easy to tell a story of how past-month cocaine use skyrocketed among 14-29 year old males according to X source, or how lifetime marijuana use fell in high school-age women according to Y. The main trick that opponents use is measuring lifetime drug use. Portugal is a very conservative country; drug use is pretty new and most of the older generation wasn’t involved. So as time goes on and more and more people try drugs but “un-trying” drugs isn’t a thing, the percent of the population who have tried drugs inevitably goes up. This definitely happened but isn’t a fair reflection of any specific reform. The authors find that in the past decade or so, there has been a bit more short-term experimentation with drugs, but less long-run use. They conclude: As shown in Figure 2, general population (aged 15–64) trends for recent and current drug use in Portugal indicate minimal if any changes between 2001 and 2007. Instead, rates of discontinuation of drug use (the proportion of the population that reported ever having used a drug but opting not to in recent years) increased, which reinforces that just as in the school populations, the growth in lifetime-reported use reflected predominantly short-term experimental use. Increases in recent and current drug use were more notable in some cohorts, particularly those aged 25 to 34 (albeit, with a maximum of 7% of any one cohort reporting recent use, absolute levels remained low). But as shown in Figure 3, recent and current drug use declined among those aged 15–24, the population who were most at risk of initiation and long-term engagement. The available evidence thus gives grounds for arguing that while there was some growth in the scale of drug use in post-reform Portugal, there was an overall positive net benefit for the Portuguese community. What about San Fransicko’s main point - that as the US has wound down the War on Drugs, drug overdose rates have sextupled? I think this is mostly not causal. I think the sextupling of overdoses is a combination of expansion in prescription opioid use, various forms of social decay making people less happy and therefore more likely to use drugs, and “improvements” in drug “technology” and the “supply chain” (eg production of fentanyl in China). I don’t know of any source that attempts to tease out the exact contribution of all of these things, but I would note that overdose deaths have risen the most in very conservative Midwestern states that haven’t walked back the drug war as much as California. Conclusion: As usual, I appreciate San Fransicko’s corrections to the prevailing narrative, but its own additions are dubious. Its claim that Portugal saw increased drug-related deaths seems false as far as I can tell. Its claim that it saw increased drug use depends on your definition, but is misleading and not the most natural way to sum up the evidence. Claim 6: San Francisco’s Soft-On-Crime Policies Led To Rising Crime Ten years ago, the news was full of stories about how some teenager stole a gumdrop and was sentenced to nine hundred billion years in jail. At some point, there was a genre shift to stories about how some hardened criminal murdered fifty people with an axe and the judge let him go with a warning because having jails felt racist. Source: Ed West, do note that this example is from the UK How suspicious should we be of each type of story? There will always be an extreme right tail of overly harsh sentences, and an extreme left tail of overly lenient ones. Were the 2000s really as draconian as they felt? Is the modern era really as pathetic? Or is it all just a function of who you read and what agenda they’re pushing? Shellenberger: During California governor Jerry Brown’s time in office, voters passed several reforms aimed at reducing the size of the prison population. In 2012, voters passed a change to the Three Strikes law so that the third strike imposes a life sentence only if the new felony was serious or violent. In addition to lowering punishments for drug possession, Proposition 47, which voters passed in 2014, redefined shoplifting, forgery, petty theft, and receiving stolen property as misdemeanors when the value in question does not exceed $950. In 2016, voters approved a proposition that shortened the time it took for some nonviolent offenders to be eligible for parole and which released nonviolent offenders into drug treatment and rehabilitation. Property crimes rose in San Francisco starting in 2012. Larceny, which is shoplifting and other petty theft, rose 50 percent, from roughly 3,000 incidents per 100,000 people in 2011 to about 4,500 in 2019. Property crimes as a whole, which include larceny, motor vehicle theft, and burglary, rose from 4,000 incidents per 100,000 people in 2011 to 5,500 in 2019. One study suggests that Proposition 47 increased the rate of auto theft 17 percent and the rate of larceny (non-auto property) theft 9 percent, but discerning between causation and correlation may not be possible. Upon taking office in January 2020, [famously soft-on-crime San Francisco district attorney Chesa] Boudin followed through on his campaign promises. Instead of prosecuting and incarcerating people for breaking car windows to steal money and other items from inside, Boudin proposed creating a $1.5 million fund to reimburse car owners. But there were over 25,000 car break-ins reported in 2019. If every break-in cost just $250 in repairs, the fund would need four times that amount. And what would prevent people from falsely claiming to have been robbed in order to get city money? […] Boudin opposed efforts by the mayor and the city attorney to prevent drug dealers who had already been arrested from entering the Tenderloin. “Until the city is serious about treating addiction and the root causes of drug use and selling,” said Boudin in a statement, “these recycled, punishment-focused approaches are unlikely to succeed at doing anything more than making headlines.” Home burglaries rose in early 2021 in San Francisco. Homeowners started posting on Twitter videos from their security cameras of people breaking into homes and garages. “When I first moved here we had a car break-in problem,” said Michael Solana, a writer who works for a venture capital fund. “Now we have a home invasion problem. These things are wearing on people.” Boudin attributed the rise of burglaries in San Francisco to the decline of tourism and “people in desperate economic circumstances.” Progressive supervisor Hillary Ronen agreed. “We know that [economic insecurity and inequality] is one of the root causes of property crimes specifically,” she said. But Tom Wolf and others argued that the robberies were, like the shoplifting, done by people seeking money to buy drugs and feed their addictions. “The drugstores have been shoplifted to death and that’s all because of drug use,” said Tom. “I know. I used to do the same thing when I was out there. That’s what you do. You ‘boost.’ And then you go and you sell your stuff down at UN Plaza,” an open-air drug scene. In a May 2021 city supervisors’ meeting, a representative from CVS called San Francisco “the epicenter of organized retail crime in the country” and claimed that 85 percent of the shoplifting is committed by organized theft rings. Police broke up one such ring in October 2020 and recovered $8 million of stolen merchandise. The problem goes beyond property crime. Boudin declined to prosecute two men who went on to kill people. One man had been repeatedly arrested for stealing cars, despite having just been released from prison earlier in the year, and appeared to be abusing meth. On New Year’s Eve, 2020, the man killed two people while driving intoxicated. Police found inside of his car a semiautomatic handgun and twenty-three grams of methamphetamine. On February 4, another intoxicated driver killed a pedestrian in a stolen car. The San Francisco police had arrested him in October 2020 for possessing a stolen car, a tool for stealing cars, and what appeared to be meth. Boudin chose not to pursue charges. In December, the California Highway Patrol arrested the man again for driving a stolen vehicle under the influence. Again he was not prosecuted. The accident victim, an immigrant from Kenya, and his wife had moved to San Francisco two weeks before the fatal crash. “I blame the DA,” said the widow of the victim. The suspect, she said, “was someone who was out in the public who shouldn’t have been in the public. It was completely avoidable.” Tom said he could feel the difference on the streets. “Drug dealing is unabated and it’s not one guy, it’s fifty guys dealing fentanyl and meth,” he said. “And it’s going unabated because the district attorney says, ‘These are the nonviolent, quality-of-life crimes,’ and ‘I’m not going to prosecute them.’” [..] District Attorney Boudin was offering weaker sentences than even defense attorneys were requesting, according to Vicki Westbrook of San Francisco. “There’s a defense attorney who said, ‘It used to be that I would argue for this deal in court with the DA but now I don’t say anything because the DA is going to offer me a deal better than what I would have suggested. Somebody shot up the street with an automatic weapon. The first offer was six months in jail or time served plus two years of probation or something. And then [the DA] said, “How about thirty days in jail?”’” Vicki laughed. “You really can do anything in San Francisco,” she said. “If you do get arrested, chances are you’re going to be out of jail in less than thirty days for damn near everything except maybe killing somebody and maybe even then, too. It’s hard to say at this point.” Taking each of these points individually: Proposition 47 There are two good big studies on the effects of Prop 47, one by Public Policy Institute and one by some UCI criminologists. The PPI study finds that the proposition increased theft and car break-ins by about 10%. The UCI study finds the same, but notes that under different assumptions the effects wouldn’t quite obtain statistical significance. This seems a bit too much like post hoc trying to get rid of an inconvenient effect, plus an effect on the border of statistical significance is different from positively finding no effect. I think a reasonable interpretation is that theft and car break-ins rose about 10% because of the proposition, just as Shellenberger says. Some pro-47 sites note that most states have some limit on how much you to have to shoplift before it’s a felony, and Prop 47 brought California closer to the national average, rather than turning it into an outlier. Chesa Boudin Chesa Boudin took office two months before the COVID pandemic began. Any attempt to separate the effect of Chesa Boudin from the effect of the pandemic is doomed. Shoplifting definitely plummeted when Boudin took office, but that’s because all the stores were closed. Murders definitely rose a little after Boudin took office, but that’s because that was also when the Black Lives Matter protests happened, which demoralized police and led to a so-far-permanent spike in murders nationwide. Percent of criminals caught definitely fell when Boudin took office, but that’s because various aspects of the justice system were closed for COVID (I will grudgingly entertain speculation that a further decrease in arrest rates from 2020 to 2021 may have been a genuine Boudin effect). In the absence of any real way to judge his performance, I think San Fransicko’s points about Boudin are plausible, though speculative. Shoplifting This one is terrible. There’s a surprisingly spirited debate here (some of you may have already read Applied Divinity Studies’ article). The debate is: everyone on the ground in San Francisco - store owners, security guards, customers, random citizens - say that shoplifting has increased massively over the past decade. But statistics mostly say it hasn’t. Source here. This is shoplifting crimes per 100,000 people. Kern County is a deep red county in California (including Bakersfield) that is known for being tough on crime. Against this, seriously, everyone says that shoplifting has obviously increased. I had a patient who worked in shoplifting prevention, he told me - his psychiatrist! Who he had no reason to lie to! - that he was constantly stressed dealing with the shoplifting surge devastating the stores he covered. Here’s the San Francisco subreddit’s response to someone posting the data showing shoplifting hasn’t risen - it’s just a lot of people laughing hysterically. What’s going on? I was able to find a different set of statistics that does seem to show a longer-term increase in shoplifting (source): The very big spike at the end might be a change in reporting by one or two stores - you can find the argument here. But it does look like shoplifting went from about 125 incidents/month in the early 2010s to more like 250/month just before the pandemic. Why is this graph so different from the other one? It looks like the top one came from the Department of Justice, and the bottom one came from SFPD. I’m not sure why these report differently. When you multiply out by 800K people in SF, by 12 months/year, and 30ish days/month, the first graph corresponds to 4 shoplifting incidents per day, and the second to 6. As LouB’s analysis here points out, that seems suspiciously low for a city of 800,000 people where stores are constantly closing because of shoplifting. Maybe off by a factor of a few hundred from what we’d expect. LouB writes: The SFPD report only references shoplifting offenses that required SFPD officers to prepare an incident report. That means either the shoplifter fought security, committed additional crimes, or stole more than $950 worth of items. It’s not that SFPD’s report is erroneous, it’s just not a representative statistic. In a parallel statistic, SFPD only completes incident reports for traffic accidents when there is an injury. Therefore, thousands of noninjury accidents are handled civilly without SFPD reports the same way thousands of shoplifting offenses are handled without reports. An insurance company would not determine premium rates based solely on SFPD incident reports, nor should readers interpret SFPD shoplifting reports as anywhere near the total picture of the shoplifting epidemic in San Francisco. (this would also explain why one or two stores changing their reporting policy can produce a spike equal to everyone else in San Francisco combined) But comparing incident reports from 2010 to incident reports from 2020 should still be apples-to-apples, unless the likelihood of reporting any given incident changed in the meantime. Did it? This news article quotes a San Franciscan who says that when they try to report shoplifting incidents, the cops tell them not to because “it doesn’t make a difference”. If cops say that now more often than they used to, it would make all these statistics meaningless. (Applied Divinity Studies claims to have an argument that shows this can’t be true. It goes something like: if San Francisco was a better place to shoplift than its neighbors - eg Oakland - then shoplifters would leave Oakland to go to San Francisco, and we would see Oakland shoplifting rates falling. Oakland shoplifting rates are falling, but no more so than the rest of the state, so there can’t be increased tolerance for shoplifting in San Francisco. I find this dubious for many reasons. First of all, many of the same reasons shoplifting is up in San Francisco - like Prop 47 or soft-on-crime progressive policies - also apply to Oakland. Second, given that shoplifting fell massively everywhere because of the pandemic, it feels dubious to try to compare different cities; maybe one city had stricter pandemic lockdowns than others. Third, do criminals really shop around for friendly jurisdictions? If so, why are so many crimes like car break-ins, concentrated in “the bad part of town”? Why wouldn’t criminals leave the bad part of town for under-exploited areas with richer residents and less competition? Maybe criminals in fact aren’t very strategic or mobile? Maybe they don’t want to stand in the BART station and then take a half-hour train ride holding a bag of stolen goods?) Maybe a better argument against this being true is how stable the shoplifting rates have been over time. Wouldn’t it be weird if (let’s say) a tripling of the real shoplifting rates was matched by a third-ing of the reporting rates (rather than a halving or a quartering or whatever)? On the other hand, here’s Shellenberger with some helpful data: Some of this is probably because of Proposition 47, which made some forms of shoplifting punishable with citation rather than arrest (but wouldn’t that be a clear discontinuity rather than a gradual trend?) But overall it sure seems like shoplifting is being taken less seriously, which might encourage people to report less. Another statistic I see is that only 2.3% of shoplifting cases result in an arrest; I don’t know how this is different from the graph above with numbers in the 30s; maybe it involves different levels of what makes something a “case”. I accept that the data don’t consistently show a spike in shoplifting. But what’s the alternative? My patient who works in loss prevention in SF stores is lying to me? The nice elderly Chinese man who sold me my last pair of glasses and chatted to me about the rampant shoplifting in his mall was lying? The San Francisco police are lying? Walgreens pretends to be concerned about shoplifting as part of a dastardly plot to close a bunch of stores for no reason? Target and CVS pretend to care about shoplifting as part of a plot to restrict their stores’ opening hours for no reason? Every big store near me has suddenly gotten a security guard at the front as part of some corporate-sponsored jobs program? Maybe the conservative narrative that soft-on-crime San Francisco must be experiencing rising crime rates took on a life of its own. Maybe it infiltrated not just the usual suspects like the SF police unions, but even such supposedly-liberal bastions as the New York Times. Maybe lots of big corporations took advantage of the fake narrative to make unpopular business decisions they were planning on making anyway. And maybe ordinary San Franciscans, confronted with everyone telling them they were in a shoplifting epidemic, started paying more attention to security guards and petty criminals who had always been there, a sort of mass hallucination that gripped everyone in the city. I can’t rule this out. Americans thought crime was rising all throughout the early 2000s, when it was in fact way down. Or maybe some statistics that we already know are off by several orders of magnitude got off by an additional factor of two or so. I think this one is more likely, but I’m genuinely not sure. Other Crime From the Economist: The Center on Juvenile And Criminal Justice puts it even more starkly, arguing that “San Francisco’s ‘Crime Wave’ Is Just One Crime”: This are potentially susceptible to the same reporting bias as shoplifting. So what about homicide? Homicide is practically always reported and investigated, making it a gold standard in crime measurement. (source) Looks pretty good until 2019. I don’t expect to gain useful information post-2020; the pandemic and the post-George-Floyd murder surge will make it impossible to evaluate for local variation. What about compared to other places? For some reason this top 20 table fails to list Washington DC, which should be just before Atlanta. SF doesn’t make the top 20, although its neighbor Oakland does. Probably most murder variation in US cities is explained by percent African-American and maybe percent Borderer; with relatively few people in these groups SF was never in the running. I’m not sure if some abstracted version of the city with all demographic factors adjusted away would have an unusually high murder rate, but at that point it would be pretty distant from any interesting real-world question. You can see the leaderboard for other types of crime here; San Francisco is often in the top ten, but never the top three. As far as I can tell, San Francisco has seen a big spike in car breakins over the past few years, with no clear trend for other property crime, violent crime, or homicides. It’s not an outlier among American cities in any kind of crime. Conclusion of this section: San Fransicko’s specific claims are basically correct, but suggest a medium-term rise in SF crime which is mostly contradicted by the data. These show stable-to-decreasing murder, stable-to-decreasing violent and property crimes other than car break-ins, and large rises in car break-ins only. The data also show stable-to-decreasing shoplifting, but I’m not sure how much to trust them vs. common sense. Honestly, I’m pretty confused here and not sure what to think. Claim 7: Jim Jones (Of Kool-Aid Cult Fame) Used To Be The Chairman Of SF’s Housing Authority Okay, this isn’t really a statistical claim that I can research different perspectives on. Still, it’s so wacky that I couldn’t resist mentioning it in this review. Jim Jones, famous for killing everyone in his Guyana-based Jonestown cult with poisoned Kool-Aid, used to be the SF government’s top guy on homelessness. Shellenberger writes: Jones married and moved first to Northern California and then to San Francisco with his wife to start a church. He called it the People’s Temple. Jones believed he was the leader of a socialist revolution. He warned of nuclear war and claimed black people would be put in concentration camps. He became a hugely charismatic preacher among African Americans, the disaffiliated poor, and young transplants to the city looking for community. Scenes from the era show a remarkably large and diverse congregation smiling and singing. The People’s Temple grew and provided services. Jones cultivated two progressive San Francisco politicians, George Moscone and Willie Brown, and mobilized people to volunteer for their campaigns […] His son and a San Francisco historian believe he stole the mayoral election for Moscone in 1975. Historian David Talbot, founder of the progressive website Salon, points to evidence that Jones committed sufficient voter fraud to account for Moscone’s narrow 4,443-vote margin of victory. “We loaded up all thirteen of our buses with maybe seventy people on each bus, and we had those buses rolling nonstop up and down the coast into San Francisco the day before the election,” said Jones Jr. “Could we have been the force that tipped the election to Moscone? Absolutely! Slam dunk. He only won by four thousand votes.” When federal investigators looked into fraud claims three years later, they discovered that all of the records were missing from the city of San Francisco’s registrar of voters. Jones also boasted of providing Moscone with black women from his congregation for sex. One time Moscone, drunk and “accompanied by a young black woman whom the politician had kindly agreed to drive home,” crashed into another car. Another time, Moscone and Willie Brown “were with a black woman in an alley at two in the morning at some restaurant in North Beach,” said a local bar owner. State legislator “John Burton was part of that gang too. They were all using marijuana and cocaine.” Said Jones Jr., Moscone would “always be there at temple parties with a cocktail in his hand and doing some ass grabbing.” A Temple member overheard Jones speaking to Moscone the day after one of those parties saying, “I want to let you know that the young lady you went off with is underage,” adding, “Now don’t worry, Mayor, we’ll take care of you—because we know that you’ll take care of us.” Afterward, Moscone made Jones the chairman of the powerful San Francisco Housing Commission. Jones cultivated progressives with money and favors. He made large donations to the ACLU, the NAACP, and United Farm Workers. Jones and Moscone met privately with vice presidential candidate Walter Mondale on a campaign plane a few days before the 1976 presidential election, and Mondale praised People’s Temple shortly afterward. Jones met with First Lady Rosalynn Carter several times. Governor Jerry Brown praised Jones. Glide Memorial Church’s Rev. Cecil Williams loved Jones. There is a photo from 1977 of a smiling Williams awarding Jones the church’s “Martin Luther King, Jr. Award.” Jones used his perch as chairman of the Housing Commission to fight for housing for the poor. He tried to use eminent domain to acquire the International Hotel, a single resident occupancy hotel. After a court sided with the hotel’s owner, Jones mobilized seven thousand protesters to picket it. By mid-January 1977, the situation had become heated. There were rumors that protesters inside the building were armed with guns and Molotov cocktails. Jones lost the legal battle in 1977, and the tenants were evicted. But the drama was a publicity victory for Jones, which burnished his image as a white savior. A conservative member of the Board of Supervisors who was defeated in the mayoral election by Moscone accused the new mayor, the San Francisco Chronicle, and the rest of the city establishment of being blind to Jones’s extremism. “There’s no radical plot in San Francisco,” insisted Moscone, in response. “There’s no one I’ve appointed to any city position whom I regard as radical or extremist.” Willie Brown, a powerful state legislator from 1964 to 1995 before becoming mayor in 1996, “seemed oblivious to Jones’ hucksterism and demagoguery,” notes a historian. Brown was master of ceremonies at a dinner for Jones in the fall of 1976 attended by an adulatory crowd of the rich and powerful, including Governor Jerry Brown. “Let me present to you a combination of Martin King, Angela Davis, Albert Einstein . . . Chairman Mao,” he said, to loud applause. And yet Jones was contemptuous of Brown even as Brown did Jones more and more favors. Jones mocked Brown for his designer suits, sports cars, and women. Once, while Brown was addressing the congregation and Jones was seated onstage behind him, Jones flipped his middle finger up to mock him. San Francisco’s establishment stood by Jones even after a California magazine, New West, owned by Rupert Murdoch, published an exposé of Jones’s beatings of Temple members and financial abuses in August 1977. The article was written by a San Francisco Chronicle reporter and was meant for the Chronicle to publish. But the newspaper killed the story because it didn’t want to alienate Jones, whom it viewed as central to its plans to expand the Chronicle’s circulation in the heavily African American Fillmore District. Jones also managed to avoid investigation and prosecution in part by getting the district attorney to hire as deputy district attorney Jones’s longtime attorney and confidant. Progressives defended Jones against the New West article. At a rally in the summer of 1977, Willie Brown said, “When somebody like Jim Jones comes on the scene, that absolutely scares the hell out of most everybody occupying positions of power in the system.” Angela Davis sent a radio message broadcast over the cult’s compound, Jonestown, in Guyana. “I know you’re in a very difficult situation right now,” she said, “and there is a very profound conspiracy designed to destroy the contributions which you have made to the struggle.” After visiting Jonestown, the attorney to the Black Panthers said, “I have seen paradise.” Harvey Milk, too, was tarnished by his association with Jones. In the fall of 1977, Milk wrote to President Carter’s secretary of health, education, and welfare requesting that Social Security checks be sent to elderly Temple members in Guyana. “People’s Temple,” wrote Milk, has “established a beautiful retirement community in Guyana.” In truth, the cult was disintegrating. Jones separated families and lovers, pitted relatives against each other, and forced neighbors to inform on each other. Jones sent people who violated the rules to solitary confinement in “the Box,” an underground cubicle where people were held as prisoners for days on end. Others were drugged. Progressives who had spent thirty years fighting to close prisons and mental hospitals found themselves praising a man who had reproduced their worst practices. In November 1978 a Bay Area congressman flew to Guyana to investigate human rights violations at Jonestown with NBC News. Jones gave the delegation a formal reception at Jonestown. A Temple member surreptitiously passed a note to one of the delegation members, saying he and another member wanted to escape. They fled the next day after a Temple member tried to stab the congressman. Jones didn’t prevent them from leaving but then sent gunmen to fire machine guns at the delegation at the airport, killing the congressman and four others. A few hours later, 907 inhabitants of Jonestown drank Flavor Aid laced with cyanide and died. Two-thirds of the victims were African American and one-third were children. Jones had told them that if they didn’t drink it they would be killed by invading soldiers from a shadowy global military conspiracy intent on imposing fascism and torturing children. As people started crying in grief, Jones scolded them. “Stop these hysterics,” he said. “This is not the way for people who are socialists or communists to die.” Jones’s wife protested the murder of children and had to be forcibly restrained. “We didn’t commit suicide,” said Jones in a tape recording, “we committed an act of revolutionary suicide protesting the conditions of an inhumane world.” Few were as stained by Jonestown as Willie Brown and George Moscone. “Even as the bloated bodies of the dead were removed from the jungle and the wounded were airlifted by the U.S. Air Force to hospitals in the United States,” wrote a historian, “Brown said he had ‘no regrets’ over his association with Jones.” They repeatedly disavowed responsibility. Said Moscone, “it’s clear that if there was a sinister plan, then we were taken in. But I’m not taking any responsibility. It’s not mine to shoulder.” This is Shellenberger at his best: telling us crazy stories from the recesses of San Francisco history, maybe kind of spinning the narration in a way that makes all progressives seem guilty by association, but with the tale itself so gripping that it’s hard to be mad. And Jones wasn’t alone. This was the golden age of San Francisco cults, when (Shellenberger tells us) “more than half of all high school students in the San Francisco Bay Area reported at least one recruiting attempt by a cult member, and 40 percent reported at least three contacts.” This chapter of SF history came to an end in 1978, when Dan White, who had just resigned from San Francisco’s Board Of Supervisors (ie City Council) entered City Hall through a window and assassinated Mayor Moscone and fellow Supervisor Harvey Milk, then successfully got charges reduced to manslaughter through a legal manuever that has gone down in history as “the Twinkie Defense” (realistically the defense was that he was depressed, but reporters seized on a comment that implied it was because he ate too many Twinkies). Everything about 1970s San Francisco was like this. With the Mayor and his right-hand-man both dead, San Francisco leadership ended up in the hands of previously second-tier politician Dianne Feinstein. Feinstein was what passed for a moderate in 1970s SF (which meant she had been targeted for assassination by various left-wing groups - she survived when a bomb left on her windowsill failed to explode). In Shellenberger’s telling, she managed to clean up some of the mess and restore a semblance of normalcy. San Francisco never forgave her. Moscone - voting fraud committer, underage sex enjoyer, and Jim Jones’ bff - is beloved as a martyr in today’s SF, but (the book points out) Feinstein is so loathed that in 2021 the Board of Education voted to rename Dianne Feinstein Elementary School. The Moscone Center is 2 million square feet and can fit about 10,000 people. Not to be confused with the Moscone Recreation Center, Moscone Station, or Moscone Elementary School. Meanwhile, all Dianne Feinstein got was one lousy elementary school and the Tithonus package of eternal life without eternal youth. Claim 8: The Intolerant Left Shuts Down Debate On These Issues Another one that’s probably hard to do a randomized controlled trial on. You could probably predict that this one was coming - it’s a necessary narrative beat in this genre of book. I think this beat is good. My impression is that people who aren’t themselves public figures disagreeing with left-wing ideas still don’t understand how scary it is and how much hate you get. Maybe now that 2/3s of every political essay written over the past five years is about this topic, people will finally get it through their thick skulls that it exists and is bad. I would also note that “traumatizing the sorts of people who write popular books about politics, in a such a way that they feel compelled as a sort of self-therapy to write page after page telling readers how angry they should be at you and your whole coalition” isn’t great political praxis. I would like people to figure this out and stop doing it. Anyway, Shellenberger is doing his part in this effort: In 2001, the San Francisco Coalition on Homelessness wheat-pasted posters of a fake front-page San Francisco Chronicle across town. Just beneath the masthead a large headline read “Fuck the Homeless!” right above a picture of San Francisco mayor Willie Brown laughing. Below his photo was the headline “Save the Tourists.” Progressives level the same charges at people thirty years later. “Because of some of the stuff I say,” said a community activist in Seattle’s historically black Capitol Hill neighborhood, “people say, ‘Oh, she’s not for them.’ But I have a heart for homeless and mentally ill. Most of my family works with the mentally ill.” Noted a Chronicle journalist in 2017, “Inevitably, homeless advocates and others will say, ‘You’re not compassionate,’” in response to stories about homeless encampments. “They called me a racist,” said Tom. “They accused me, a guy who used to be homeless, of demonizing the homeless, because I’m asking for accountability.” I found myself similarly accused. In 2019, after I published an article for Forbes about the homeless crisis, a progressive homeless activist accused me on Twitter of having written my article to “make money off of a fear tactic” of “fueling hatred [and] even increasing violence against homeless people.” After I asked the former San Francisco supervisor for the Tenderloin neighborhood, former mayoral candidate Jane Kim, how such a progressive city ended up with so much suffering, she said, “My concern, Michael, just to be very honest, is that when that kind of messaging goes out, violence against people who are unhoused goes up.” […] I soon discovered in my research that I was hardly the first person that progressive elected officials and homelessness advocates had accused of fomenting violence against unhoused people. Many others had been criticized for far worse over the years, including San Francisco’s highest elected officials. “The criticism [by progressive homelessness advocates] was heavy, political and personal,” wrote former mayor Willie Brown in his 2008 memoir. “People accused me of abandoning the problem when I was working daily to try and get a solution going. It was brutal. . . . I had become demonized, and my own efforts belittled.” It is notable that the result of such personal attacks is to frighten off people seeking to change, and perhaps improve, the situation. “The problem” of homelessness, concluded Mayor Brown within nine months of entering office, “may not be solvable.” And [Quoting Chris Rufo]. “The chief of psychiatry in a public hospital system in one of the largest California cities told me, ‘I know for a fact, and all of my colleagues know, that what we actually need to deal with the problem in the biggest cities in California is long-term residential secure psychiatric care. But I can’t say that publicly because I would be disemboweled by the activist left. My job would be in jeopardy. My reputation would be in jeopardy. My whole life would get turned upside down for even broaching the subject of expanding secure mental health facilities and compulsory mental health treatment.’ And I said, ‘So what’s the solution?’ and this person said, ‘We muddle through.’” And: In San Francisco, radical left activists protested [African-American] Mayor London Breed in front of her home. Breed said the protesters were “all white people. But that didn’t bother me as much as the taunting of me coming outside with firework torches in their hands looking like what used to happen when the KKK would show up to black people’s houses to burn their houses down.” While I was reading the book, I came across this tweet, which suggests that being unimpressed with SF’s lefty homeless activist scene is not limited to Michael Shellenberger: Claim 9: European Cities Like Amsterdam Successfully Solved Their Own Drug And Homelessness Problems By Doing The Opposite Of SF Shellenberger bases his plan to solve these problems on ideas that he says were pioneered in Amsterdam and spread to other European cities. In the 1980s, Amsterdam had the kinds of problems San Francisco deals with now: open-air drug markets, overdose deaths, homelessness, and crime. But in the 90s, they admitted they had a problem and took decisive action: What’s the secret?” I asked him. “Amsterdam has decriminalized marijuana and many other drugs but I haven’t seen any homeless. What is San Francisco doing wrong?” Rene said that in the 1980s, the Zeedijk neighborhood in Amsterdam was a lot like the Tenderloin [the worst part of San Francisco] today. There was open-air drug use, particularly of heroin, and needles strewn about, as well as crime. People started to flee the neighborhood, worsening its slum conditions. Homeless people squatted in abandoned buildings. “We had ghettos where it was not safe to go,” said Rene, who started working in the neighborhood as a nurse in 1985. It was considered a “no go” zone. “We had a lot of people from abroad who came to Amsterdam because our heroin was so good. But our heroin was so good that they died from it.” At first the city tried a “helping approach” exclusively, offering addicts clean needles, methadone, and other forms of help without any law enforcement, but it didn’t work. “In the eighties we just wanted to help people,” said Rene. “We started with methadone programs and medical treatment. We did a lot of work without much of a carrot and a stick. It was really a disappointment. They just used the methadone to stay addicted. They dealt drugs and committed other crimes. They lied and cheated about it. We were just supporting a different kind of market. We had to learn the hard way [...] The Amsterdam City Council asked the Amsterdam Municipal Health Service to develop a strategy to deal with “unmotivated drug users”...The police broke up the open-air drug scene and health workers were on hand to offer methadone, treatment, and shelter. The police broke up gatherings of more than four or five users, but did not treat personal and private use as a crime. Officers ticketed violators, and if users did not pay their fines, which was frequent, the courts ordered arrests, and sentenced individuals to follow a treatment plan or face incarceration. “For every individual homeless person, we make a plan,” said Rene. “We made tens of thousands of those plans.” Plans are overseen by a caseworker and a team that may include a psychiatrist, shelter provider, service provider, judge, employer, parole officer, and police officer. “You need people in the police and health department working together,” he said. What Amsterdam did was the same as other major European cities. Lisbon, Frankfurt, Vienna, and Zurich all dealt with their open-air drug markets, using a combination of law enforcement and social services. Crucially, Amsterdam and other European cities prevented services from being concentrated in a single neighborhood, since their concentration often enables an open-air drug scene to thrive [...] The efforts worked. “We had several thousand people who were addicted to heroin in the eighties and nineties,” said Rene. “Many died. Today we have four or five hundred people addicted to methadone. And we have about 120 in Amsterdam who we supply heroin to on a medical basis because methadone doesn’t work for them. They have to use heroin.” The Amsterdam strategy goes something like: Break up open-air drug markets and anywhere that more than 4-5 drug users are congregating. Yes, people can just use their drugs in private, but this is legitimately better. Open-air markets normalize drugs with their blatantness, and make it hard to quit for the same reason it’s hard to diet if your partner leaves boxes of donuts out in the house every day.
Inline links: Housing First For Homeless People With Active Addiction: Are We Overreaching?, here, https://substackcdn.com/image/fetch/$s_!sgvd!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F5250de4e-08fe-460d-87a6-58654d6e57bf_880x292.png, 24-month followup, https://substackcdn.com/image/fetch/$s_!OZrF!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2Facb2c749-e076-4b50-ae77-83576401a16f_556x639.png, a proper randomized study, Somers, Moniruzzaman and Palepu, Padgett et al, Kirst et al, Milby, a $14 billion budget, This article, talk about, another article about people objecting to, boarding houses, Politico, has completed only 700 units, Considerations On Cost Disease, this comment, An article, https://substackcdn.com/image/fetch/$s_!4wi2!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F00f02bfe-c696-415d-ba80-5edb997021cb_809x487.png, survey, This app, this webpage, this site, many people, among the strongest proponents of both, these numbers, here, https://substackcdn.com/image/fetch/$s_!msoV!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F8b34d51f-d6ed-43ee-a069-5e74fe75c421_1812x1102.png, an anti-drug Australian think tank, https://substackcdn.com/image/fetch/$s_!CN2E!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F85656c06-22bc-4076-80f0-b7a9bd4aa0d3_574x331.png, A Resounding Success Or Disastrous Failure: Re-examining The Interpretation Of Evidence On The Portuguese Decriminalisation Of Illicit Drugs, https://substackcdn.com/image/fetch/$s_!VvrE!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F2341944a-388d-4da9-9788-8474567b83fc_540x737.png, Ed West, Public Policy Institute, UCI criminologists, Applied Divinity Studies’ article, https://substackcdn.com/image/fetch/$s_!aTNC!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2Fa27aeb21-ed87-4e67-b82c-b3ceecee7082_500x238.png, here, Here’s the San Francisco subreddit’s response, https://substackcdn.com/image/fetch/$s_!_NL6!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2Fcf7dc478-45d3-487d-8c29-8bc7cdf182dd_2400x1500.png, LouB’s analysis here, This news article, only 2.3% of shoplifting cases result in an arrest, New York Times, the Economist, https://substackcdn.com/image/fetch/$s_!58I3!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2Fc63dc7bc-1f8e-49fd-9c68-61c85278d69e_608x662.png, San Francisco’s ‘Crime Wave’ Is Just One Crime, https://substackcdn.com/image/fetch/$s_!h17s!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F956c0917-2a9b-4ff7-a08e-6aee5030583a_590x376.png, https://substackcdn.com/image/fetch/$s_!TkFS!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F5c5faa01-ac22-48a2-96fe-47efb6f52514_616x334.png, source, https://substackcdn.com/image/fetch/$s_!Bg2w!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F18e49c63-16ba-4878-96e6-aec12d7c5953_481x667.png, percent African-American, percent Borderer, here, the Twinkie Defense, https://substackcdn.com/image/fetch/$s_!8wK3!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F683b9754-f663-47ad-88f5-aa99bc208ec8_1401x622.jpeg, https://twitter.com/weheartprez/status/1526983899309432832
Continuing from San Fransicko: There is evidence that privacy and solitude created by Housing First make substance abuse worse. A study in Ottawa found that, while the Housing First group kept people in housing longer, the comparison group saw greater reductions in alcohol consumption and problematic drug use, and greater improvements to mental health, after two years. “One reason for the surprising results,” wrote the authors, “may be that aspects of the Housing First intervention, such as the privacy afforded by Housing First and harm reduction approach, might result in slower improvements around substance use and mental health.” Okay, but the next sentence after the one the book quoted was the researchers admitting that oops, we also totally forgot to randomize our groups in any way, so the experimental and control groups had totally different levels of severity and maybe that was why they found this weird thing (this is non-obvious, because we’re looking at change over time rather than raw differences between groups, but the authors discuss some reasons why different groups might change differently over time). A few years later these same researchers did a proper randomized study and it found no difference in drug use between the two groups. Somers, Moniruzzaman and Palepu found no difference in drug use between Housing First and other subjects. Padgett et al found the Housing First group actually did better, although they are another victim of the epidemic of randomization failures in this space. Kirst et al, no difference in drug use, but Housing First better with alcohol. Milby found that housing contigent on abstinence worked better than housing not contigent on abstinence, which Shellenberger could have used to support his thesis, but even Milby found that housing not contingent on abstinence worked better than no housing! To summarize: I can find seven studies on this topic, only one of them agrees with San Fransicko’s thesis, and the authors admit that it’s weak. I accuse San Fransicko of citing only that one and pretending all the others don’t exist. (actually, I accuse it of doing that plus citing a line from a review claiming another study found this, but as far as I can tell that study did not actually find it) This is extra annoying, because all the popular news articles on Housing First gush about how it definitely decreases substance use and everything else bad. Shellenberger could have made the excellent point that all of these progressive journalists were totally wrong! This would have been an interesting, important, and completely true act of virtuous data journalism! Instead he tries to hold up a lonely negative result as representative, and ends up just as wrong but in the opposite direction. Continuing in San Fransicko: Researchers have found ways to use housing to reduce addiction. Between 1990 and 2006, researchers in Birmingham, Alabama, conducted clinical trials of abstinence-contingent housing with 644 homeless people with crack cocaine addictions. Two-thirds of participants remained abstinent after six months, a very high rate of abstinence, compared to other treatment programs. Other studies found that around 40 percent of homeless in abstinence-contingent housing maintained their abstinence, housing, and jobs. In a randomized controlled trial, homeless people were given furnished apartments and allowed to keep them unless they failed a drug test, at which point they were sent to stay in a shelter. Sixty-five percent of participants completed the program. Three similar randomized controlled trials also found moderate to high rates of completion. And participants in abstinence-contingent housing had better housing and employment outcomes than participants assigned housing for whom abstinence was not required. All of this seems basically true. It turns out that over longer periods of time, Housing First may not even outperform contingency in terms of keeping people housed. In the spring of 2021, a team of Harvard medical experts published the results of a fourteen-year-long study of chronic homeless placed into permanent supportive housing in Boston. Most studies of permanent supportive housing, including the Kushel study conducted in Santa Clara, only study the newly housed homeless for a span of around two years. The study found that 86 percent of the homeless, who were referred based on length of time living on the streets, suffered from “trimorbidity”—a combination of medical illness, mental illness, and substance abuse. The authors found that after ten years, just 12 percent of the homeless remained housed. During the study period, 45 percent died. The authors concluded that, because the chronically homeless had such higher rates of physical and mental illness, “the supportive services, essential to the PSH model, may not have been sufficient to address the needs of this unsheltered population.” This study was done on an especially severe subgroup of homeless people. There was no control group, so Shellenberger shouldn’t claim we have any evidence about whether Housing First can “outperform contingency”. Shellenberger counts people who died as “unhoused” to get his 12% number; if he didn’t do this, the number would be 23%. Only 23% of people given housing retained after ten years sounds bad. But you could change this number to whatever number you wanted by changing the severity of the subgroup selected for the study. Select people who are even crazier and more disturbed than these people, and you can have 0% retained after ten years; select high-functioning people with no problems, and you can get 100% retained after ten years. (or maybe not - the study doesn’t say why people left the program. It mentions that one possible outcome is having to go to a nursing home because they had grown too sick or old to support themselves. I am not sure that “23% stay in this program” means “77% are back on the street and all their care has been a total failure”.) Conclusion: Housing First seems to work in getting people housing. It probably also helps people use fewer medical services, and it might or might not save money compared to not doing it (probably more likely when treating very severe cases, less likely in areas with high housing costs). It probably doesn’t affect people’s overall health or drug use status very much. San Fransicko is right to call out all the people promoting it beyond what the evidence supports, but then goes on to attack it beyond what the evidence supports. Interlude: Why Can’t We Just House All The Homeless? This is the question many of the California gubernatorial candidates asked. California has lots of money. There aren’t that many homeless people. Everyone is already committed to Housing First. So why don’t they have houses already? San Francisco has about 7,000 homeless people. The median SF apartment costs about $3,000 per month (presumably the government officials in charge would be trying to buy cheaper-than-median apartments for this project, but they seem bad at that, so let’s stick with median as a high-end estimate). So that’s $250 million/year to rent every homeless person an apartment. San Francisco has a $14 billion budget, although some of that is locked in nondiscretionary programs. So this effort would take about 2-3% of the city budget. Given how many people have both altruistic and selfish objections to the current level of SF homelessness, I can’t imagine that isn’t a better use of the money than whatever it’s being spent on now. So why hasn’t this happened? The closest thing I can find to the “rent apartments” plan is Governor Newsom’s “rent hotel rooms” plan, Project Roomkey. This was a short-term pandemic program. This article says it cost $4,000 per month, which seems reasonable - it provided residents with a hotel room, meals, security, and “custodial services” for just above a hundred dollars a day. So how come nobody has made it permanent or scaled it up? The homeless themselves don’t seem very positive on the project. They talk about “jail”-like conditions, including curfews and bans on visitors. I don’t know if this is the usual nanny-state-ism, or an attempt to reassure hotel owners / other residents / local communities that the influx of homeless people won’t cause them problems. If the latter, it hasn’t worked. From here: Jenna Abbott, executive director of the River District Business Association, said having a Roomkey motel in her neighborhood has been difficult. The site — which is in an area with large number of unhoused people — has drawn family and friends of Roomkey residents who haven’t been housed but “camp close to that hotel,” some with the goal of gaining a room, Abbott said. That’s led to more loitering, public drunkenness and trash outside the restaurants, gas stations and other businesses in the area, she added. And here’s another article about people objecting to local hotels accepting homeless people, which focuses on some combination of zoning, code, and public safety concerns. Everybody - the homeless, their advocates, various experts - interviewed in the article - agrees that the hotel rooms are kind of dehumanizing and much worse than having real housing. And this article suggests that government budgeters believe it’s not cost-effective compared to alternatives. Since the homeless don’t like it, and it’s expensive, almost everyone seems to agree it made sense as a short-term COVID measure only. The government’s preferred medium-term solution is single resident occupancy (SRO) hotels. These are big apartment/hotel-like structures where everyone has a small bedroom and then there are communal bathrooms and maybe kitchens. These used to be the archetypal living situation for poor Americans (Matt Yglesias talks about them as “boarding houses” here). But moral reformers banned them in the 1900s on the grounds that they were slums - I think this is the usual “surely the reason poor people live bad lives is because capitalists oppress them by selling them cheap low-quality goods, and if we just ban selling people cheap low-quality goods, everyone will have high-quality goods and poor people will live great lives!” argument. Somehow this failed to work and homelessness got worse over this period, but there are still some SRO hotels left, and the government got them and converted them to public housing for homeless people. Shellenberger does not have high opinions of these: The Tenderloin [district of San Francisco]’s single resident occupancy hotels . . . have for decades been dominated by a culture of heavy substance use and prostitution. “Of the people in supportive housing in San Francisco, 93 percent have a major mental illness that we can name,” said a housing policy maker. “That is very, very high. Eighty percent use cocaine, speed, or heroin every thirty days, or get drunk to the point of unconsciousness.” Tom Wolf, a former Salvation Army caseworker and a member of San Francisco’s Drug Dealing Taskforce, says the city’s supportive housing facilities are themselves a major market for illegal drugs. “Go down the street to the Camelot Hotel on Turk Street,” said Wolf. “Almost everyone that I’ve seen in those hotels are using. The last front desk guy that was working there got busted because he was selling crack. The actual guy that works in the single resident occupancy hotel is selling crack! It’s insane, man.” In any case, there are only so many of these still left. The government often announces plans to buy defunct regular hotels and convert them into these structures, which would indeed be a medium-term solution for housing the homeless, except that they usually get bogged down in fights about code. Politico discusses one of these attempts in New York City (h/t Marginal Revolution): “There are very few hotels that physically could be converted and comply with the requirements of today’s zoning and building code without substantial, expansive reconstruction, partial removal or demolition,” said James Colgate, a land use partner at Bryan Cave Leighton Paisner LLP who has advised clients on zoning issues including the conversions of hotels. “That would increase the costs greatly.” For example, a building’s elevators, doorways, or rooms may be slightly short of the size required for a residential structure. Residential buildings are also required to have a certain amount of rear-yard space that a hotel may not have. “You would literally have to be chopping off part of the building,” Rosen said. …The legislation dictates that each unit include a kitchen or kitchenette with a full-sized refrigerator, cooktop and sink — something Rosen said made utilizing the program “simply too expensive.” “This is the classic case of the perfect being the enemy of the possible,” said Mark Ginsberg, a partner at the firm Curtis + Ginsberg Architects, which has worked on hotel conversions. Some advocates who pushed the creation of the program say those provisions were necessary to ensure it didn’t generate substandard housing […] “We didn’t want a program that cut corners to make it more palatable to developers,” said Joseph Loonam, housing campaign coordinator for the progressive advocacy group VOCAL-NY. “We wanted a program that centered the needs of homeless New Yorkers, which is true high quality affordable housing where they can have full autonomy and dignity.” As Marginal Revolution pointed out, Loonam got what he wanted; the expensive, over-regulated program was unpalatable to developers, with only one company putting in an offer; for whatever reason, NYC refused to go with that one company, and no housing was produced. But fine, these are also terrible, and they’re only medium-term solutions anyway. What about building real, long-term apartments for homeless people? Shellenberger tells the story of Los Angeles’ Proposition HHH, which raised $1.2 billion to do exactly this. They hoped to build ~10,000 units for the homeless, at a projected price of $140,000 each; since LA had about 30,000 homeless people at the time, this would solve a third of the problem - a good start. (how do these numbers line up with my back-of-the-envelope calculation for SF above? I talked about renting rather than building, but usually annual rents = 1/20th or so of total prices, so I was estimating about $700,000 per person. This is probably partly because SF costs more than LA, and partly because I was imagining median apartments whereas LA is probably working on very cheap apartments) But in fact, five years later, LA has completed only 700 units, and the cost per unit has spiralled to $531,000 each. Nobody has a good explanation for what happened, with Shellenberger quoting one local service provider who said a lot of it was “bullshit costs”. Now might be a good time to re-read Considerations On Cost Disease. [Update: this might not be accurate - see this comment] This seems to be a general problem: everyone is committed to Housing First and to long-term good solutions rather than short- or medium- term mediocre ones. But that means building housing. And some combination of NIMBYism and over-regulation means building housing is somewhere between ruiniously expensive and impossible. Claim 4: Shelters Are Unpopular Among Progressive Activists And The Homeless Themselves San Francisco doesn’t have more homelessness than eg New York, but almost all the homeless in New York live in shelters and stay off the street. Why doesn’t that work here? Shellenberger: In the context of cities with permissive attitudes toward drugs, like San Francisco, many homeless people stay in [tent] encampments to use illegal substances more freely and easily than they can in the shelters. Many policy makers understand this. “I went out with a team twice to have conversations with people to get an understanding of what they’re dealing with,” said Mayor Breed in 2020. “It was absolutely insane. Most of the people did not take us up on the offer [of shelter and services].” Even people who would prefer to live in sober environments say they do not want to quit their addictions. “When we surveyed people in supportive housing in New York,” said University of Pennsylvania homelessness researcher Dennis Culhane, “almost everybody wanted their neighbors to be clean and sober but they didn’t want rules for themselves about being clean.” In 2016, after the city of San Francisco broke up a massive, 350-person homeless encampment, dozens of the homeless refused the city’s offers of help. Of the 150 people moved during a single month of homeless encampment cleanups in 2018, just eight people accepted the city’s offer of shelter. In 2004, just 131 people went into permanent supportive housing after 4,950 contacts made by then-mayor Newsom’s homeless outreach teams. An article by a former homeless person explains the problems with shelters beyond just “can’t use drugs”. Residents are crammed into a small space with 300 other homeless people. Lice and bedbugs are everywhere. Everybody catches every disease. Everybody has stories about getting raped or beaten up. Invasive moralizing about drugs somehow exists side by side with rampant drug use. Shelters are gender segregated, which means straight people can’t stay with their partner. Most shelters ban children and nobody has any idea what to do with them. Most shelters ban pets - a lot of homeless people have dogs for protection or companionship, and you can’t just store them somewhere while you’re sheltering. Although some lucky people can get 90-day beds, other people need to apply for beds on a day-by-day basis, which requires waiting in line several hours every day. Users talk about rampant cutting in line, denying cutting in line, false accusations of cutting in line, etc. Most shelters kick people out between 9-5, either to save on staffing costs or in the hopes that they’ll get a job. But many have strict curfews requiring people to be back by 5 PM sharp, which can make jobs impossible - if your boss doesn’t let you out until 5 and you have a half-hour commute, how do you get back to the shelter on time? Results of a survey at one of SF’s new Navigation Centers at why their clients refused to go to normal shelters. But even the homeless people who do want to go to shelters mostly can’t get in. This app gives the current status of San Francisco’s homeless shelter waitlist. If you applied today, there would be 900 people ahead of you in line for one of the city’s 1500 - 2500 shelter beds. The app says that the median wait time is 826 days. So however many homeless people don’t want to go to shelters, we’re not building enough shelters to serve the ones who do. Why not? Shellenberger again: In the spring of 2021, Friedenbach published an op-ed opposing a proposal considered by the San Francisco Board of Supervisors to create, within eighteen months, sufficient homeless shelters and outdoor “Safe Sleeping Sites” for all of the city’s unsheltered homeless. “One can simply take a look to New York City,” she wrote. “Their department spends about $1.3 billion dollars of its budget on providing shelter for their unhoused population while thousands remain on the street. . . . As a result, New York has a higher rate of homelessness than San Francisco.” Housing First advocate Margot Kushel of the University of California, San Francisco agreed. “The problem with New York—and I spend a lot of time with people working in the system in New York—is that they spend an estimated $30,000 for each person per year to keep them in shelter. That’s not what we want to do. Because if you create the shelter and you don’t create the housing, then people are just in shelter forever.” Housing First advocates oppose shelter in Los Angeles. “Why haven’t we solved homelessness?” asked Housing First creator Sam Tsemberis. “Because [Los Angeles mayor] Eric Garcetti [has] Andy Bales [saying,] ‘You need emergency housing.’ ‘These people need to be cleaned up.’ ‘They need to be sober.’ ‘They need Jesus before they’ll be ready for housing.’ I said, ‘People should be housed and then maybe they’ll get sobriety and Jesus and the rest.’ We’re definitely on polar opposites of the whole thing.” Advocates for the homeless at the national level similarly oppose more shelters. “I don’t agree that we should be building more transitional housing,” said the head of the National Alliance to End Homelessness. […] In other words, the reason that there are so many homeless people on the streets in San Francisco is that both progressive and moderate Democratic elected officials, and the city’s most influential homelessness experts and advocates, have for two decades opposed building sufficient shelters. And that is unlikely to change even after San Francisco starts spending hundreds of millions more per year on the problem and might even get worse. This basically seems true. I found this webpage of a former SF Supervisor candidate a helpful corroborating source. He was running on a platform of “maybe we should build some homeless shelters”. He lost. You can also find a bunch of webpages by the sorts of people Shellenberger is complaining about, for example this site: Sup[ervisor] Rafael Mandelman today pushed his new legislation that would require the city to offer at least temporary shelter to everyone living on the streets, a step that some say would lead to more homeless sweeps and do nothing to create permanently affordable housing . . . [our] Coalition has argued for years that the solution to homelessness is housing—not temporary shelter, which may never lead to housing. The ex-supervisor candidate gives some helpful numbers: permanent housing costs about $600,000 per person housed. Shelters cost between $20,000 and $30,000 per person housed. So SF could build enough shelters to clear its waitlist for about $30 million. More recently, SF has tried a sort of compromise, opening “deluxe” shelters called Navigation Centers which avoid some of the problems of regular shelters. They also cost more than twice as much, and the city has only created about 300 beds. Also, the people in regular shelters are angry, because being in a regular shelter disqualifies you from getting into a (much better) Navigation Center. Some of them are considering leaving their shelter, going back on the streets, then waiting however many months or years it takes to get a Navigation Center bed instead. I’m not at all sure of these numbers, but it looks like of SF’s ~7,000 homeless, about 2,000 are in shelters already, and 1,000 are on the shelter waitlist. I don’t know if the remaining 4,000 have made a specific commitment not to go to shelters, or just have given up on the waitlist process. My conclusion: agree with San Fransicko about the role of progressive activists, but I think it overemphasizes the role of wanting to use drugs in why homeless people themselves sometimes avoid shelters, and underemphasizes the many other problems with them. Claim 5: Drug Decriminalization Isn’t Working California legalized marijuana in 2016. Shellenberger says that San Francisco’s commitment to drugs has gone beyond that: it has effectively decriminalized opioids, cocaine, and the rest. Any attempt to lessen use of these drugs is attacked as “stigmatizing”; instead, government policy centers around providing addicts with needles and other drug paraphernalia under the guise of “harm reduction”. Shellenberger hits all the right beats here. Like many people, he tries to undo the damage done by The New Jim Crow, a book which convinced millions of people that mass incarceration was driven by a racist War On Drugs. In fact, less than a fifth of prisoners are in for drug-related crimes. And when the government was first debating the War on Drugs and mass incarceration, black leaders were among the strongest proponents of both. The talking point at the time - among everyone from black Congressional leaders to black churches - was that the government’s failure to crack down on drug use was racist, borne of them not caring about predominantly black drug victims. And while we’ve been patting ourselves on the back about how enlightened we are for ending the drug war: Drug overdoses are today the number one cause of accidental death in the United States as a result of America’s historic addiction and overdose epidemic. Overdose deaths rose from 17,415 in 2000 to 93,330 in 2020, a 536 percent increase.Significantly more people die of drug overdoses today than of homicide (13,927 in 2019) or car accidents (36,096 in 2019). […] There are about twenty-five thousand injection drug users in San Francisco, a number 50 percent larger than the number of students enrolled in the city’s fifteen public high schools. San Francisco gives away more needles to drug users, six million per year, than New York City, despite having one-tenth the population. The part of this chapter that stood out to me as most worth looking into deeper was the section on Portugal: For decades, harm reduction and decriminalization advocates have pointed to Portugal as a model, noting that it decriminalized drugs and expanded drug treatment. In 2013, Portugal’s drug-induced death rate was sixty-six times less than that of the United States. The number of people in treatment increased by 60 percent between 1998 and 2011, with three-quarters receiving an opioid substitute like methadone or Suboxone, the brand name of buprenorphine. Drug use among 15- to 24-year-olds actually declined after decriminalization. “All drugs have been legalized,” explained Monique Tula, executive director of the Harm Reduction Coalition. “Their focus is on giving people tools, like job apprenticeships, and the means to support themselves.” […] [But Portugal] never legalized drugs. It only decriminalized them, reducing criminal penalties but maintaining prohibition. Drug dealers were still sent to prison even after the 2001 decriminalization. And Portugal does not let people addicted to hard drugs with behavioral disorders off the hook like progressive West Coast cities have done. It’s true that Portugal massively expanded drug treatment, but people are still arrested and fined for possession of heroin, meth, and other hard drugs. And drug users are typically sent to a regionally administered “Commissions for the Dissuasion of Drug Addiction,” composed of a social worker, lawyer, and doctor who encourage, push, and coerce drug treatment. And decriminalization doesn’t end drug violence. “Even if trafficking enforcement decreased, like it did in Portugal,” said criminologist John Pfaff, “illegal drug markets would still be forced to rely on violence to resolve disputes.” Indeed, prostitution and violence are ever-present in the open-air drug scenes in San Francisco, Los Angeles, and Seattle. “We are seeing behaviors from our guests that I’ve never seen in thirty-three years,” said Rev. Andy Bales, who runs the largest homeless shelter on Skid Row in Los Angeles. “They are so bizarre and different that I don’t even feel right describing the behaviors. It’s extreme violence of an extreme sexual nature.” People are not dying from drug overdose deaths in San Francisco because they’re being arrested. They’re dying because they aren’t being arrested. Decriminalization reduces prices by lowering production and distribution costs, which increases use. This was also the case for alcohol consumption. It increased after prohibition ended in the United States. Even in Portugal, drug overdose deaths and overall drug use rose after decriminalization. I was most surprised by the claim that Portuguese overdose deaths rose after decriminalization. Uncharacteristically, San Fransicko doesn’t give a citation for it, but we can try to retrace its reasoning. Decriminalization proponents tend to point to these numbers, helpfully converted to per 100,000 population and graphed here: But an anti-drug Australian think tank argues that the peak in 2001 is made up: Claims that there were more than 75 drug-related deaths in 2001 which more than halved to 34 deaths in 2002 use a figure for 2001 for which there is no substantiation. Official drug-related deaths for Portugal, taken from the latest 2018 EMCDDA Statistical Bulletin are copied below. Notice that there is no such figure recorded for 2001. They include a link to EMCDDA, the EU organization charged with monitoring these things. The link contains two datasets, both of which seem to be measuring the same thing but getting different results. One dataset starts in 2002, the other in 2008. I don’t know what the difference here is, but they’re right that neither includes 2001. If you ignore the pre-2002 data, the graph looks like this: They say “opiate”, but AFAICT these numbers are actually about all drugs. But the proponents link to the updated 2020 version of the same website, which all of a sudden does have data from 2001 and before. I don’t know why EMCDDA can’t make up its mind, but I think the Australians are wrong and the original graph is fine. On the other hand, does it really matter? Both of these show drug deaths decreasing until 2005, then going up and down a bit, then going back up again starting in 2011. I think a reasonable interpretation would be that decriminalization in Portugal did decrease overdose deaths a bit, and then they started rising again from that low baseline around the same time other European countries saw rising overdose deaths. I would also accept “these are pretty small effects and we shouldn’t ascribe any significance to them”. But San Fransicko’s claim - that overdose deaths increased after the reform - seems false. The only way I can see justifying it is taking the second graph - the one that wrongly claims there is no pre-2002 data - and then attributing the fact that twelve years after the reform lowered deaths, deaths finally rose above the pre-reform level to be the fault of the reform. This is like saying “people claim the Black Plague killed a lot of Europeans, but the European population actually rose after the Plague”, which is true in the sense that it was above its pre-Plague max by like 1600 or whatever. What about overall drug use? Here I recommend A Resounding Success Or Disastrous Failure: Re-examining The Interpretation Of Evidence On The Portuguese Decriminalisation Of Illicit Drugs, which is on exactly this topic of how people keep selectively quoting results from Portugal to prove their point. It argues that drug use is inherently hard to measure. There are four different Portuguese datasets for the time at issue, lots of different drugs, lots of different age/gender combinations, and lots of different ways of measuring drugs (did you use drugs in the past month? the past year? your lifetime?) It’s easy to tell a story of how past-month cocaine use skyrocketed among 14-29 year old males according to X source, or how lifetime marijuana use fell in high school-age women according to Y. The main trick that opponents use is measuring lifetime drug use. Portugal is a very conservative country; drug use is pretty new and most of the older generation wasn’t involved. So as time goes on and more and more people try drugs but “un-trying” drugs isn’t a thing, the percent of the population who have tried drugs inevitably goes up. This definitely happened but isn’t a fair reflection of any specific reform. The authors find that in the past decade or so, there has been a bit more short-term experimentation with drugs, but less long-run use. They conclude: As shown in Figure 2, general population (aged 15–64) trends for recent and current drug use in Portugal indicate minimal if any changes between 2001 and 2007. Instead, rates of discontinuation of drug use (the proportion of the population that reported ever having used a drug but opting not to in recent years) increased, which reinforces that just as in the school populations, the growth in lifetime-reported use reflected predominantly short-term experimental use. Increases in recent and current drug use were more notable in some cohorts, particularly those aged 25 to 34 (albeit, with a maximum of 7% of any one cohort reporting recent use, absolute levels remained low). But as shown in Figure 3, recent and current drug use declined among those aged 15–24, the population who were most at risk of initiation and long-term engagement. The available evidence thus gives grounds for arguing that while there was some growth in the scale of drug use in post-reform Portugal, there was an overall positive net benefit for the Portuguese community. What about San Fransicko’s main point - that as the US has wound down the War on Drugs, drug overdose rates have sextupled? I think this is mostly not causal. I think the sextupling of overdoses is a combination of expansion in prescription opioid use, various forms of social decay making people less happy and therefore more likely to use drugs, and “improvements” in drug “technology” and the “supply chain” (eg production of fentanyl in China). I don’t know of any source that attempts to tease out the exact contribution of all of these things, but I would note that overdose deaths have risen the most in very conservative Midwestern states that haven’t walked back the drug war as much as California. Conclusion: As usual, I appreciate San Fransicko’s corrections to the prevailing narrative, but its own additions are dubious. Its claim that Portugal saw increased drug-related deaths seems false as far as I can tell. Its claim that it saw increased drug use depends on your definition, but is misleading and not the most natural way to sum up the evidence. Claim 6: San Francisco’s Soft-On-Crime Policies Led To Rising Crime Ten years ago, the news was full of stories about how some teenager stole a gumdrop and was sentenced to nine hundred billion years in jail. At some point, there was a genre shift to stories about how some hardened criminal murdered fifty people with an axe and the judge let him go with a warning because having jails felt racist. Source: Ed West, do note that this example is from the UK How suspicious should we be of each type of story? There will always be an extreme right tail of overly harsh sentences, and an extreme left tail of overly lenient ones. Were the 2000s really as draconian as they felt? Is the modern era really as pathetic? Or is it all just a function of who you read and what agenda they’re pushing? Shellenberger: During California governor Jerry Brown’s time in office, voters passed several reforms aimed at reducing the size of the prison population. In 2012, voters passed a change to the Three Strikes law so that the third strike imposes a life sentence only if the new felony was serious or violent. In addition to lowering punishments for drug possession, Proposition 47, which voters passed in 2014, redefined shoplifting, forgery, petty theft, and receiving stolen property as misdemeanors when the value in question does not exceed $950. In 2016, voters approved a proposition that shortened the time it took for some nonviolent offenders to be eligible for parole and which released nonviolent offenders into drug treatment and rehabilitation. Property crimes rose in San Francisco starting in 2012. Larceny, which is shoplifting and other petty theft, rose 50 percent, from roughly 3,000 incidents per 100,000 people in 2011 to about 4,500 in 2019. Property crimes as a whole, which include larceny, motor vehicle theft, and burglary, rose from 4,000 incidents per 100,000 people in 2011 to 5,500 in 2019. One study suggests that Proposition 47 increased the rate of auto theft 17 percent and the rate of larceny (non-auto property) theft 9 percent, but discerning between causation and correlation may not be possible. Upon taking office in January 2020, [famously soft-on-crime San Francisco district attorney Chesa] Boudin followed through on his campaign promises. Instead of prosecuting and incarcerating people for breaking car windows to steal money and other items from inside, Boudin proposed creating a $1.5 million fund to reimburse car owners. But there were over 25,000 car break-ins reported in 2019. If every break-in cost just $250 in repairs, the fund would need four times that amount. And what would prevent people from falsely claiming to have been robbed in order to get city money? […] Boudin opposed efforts by the mayor and the city attorney to prevent drug dealers who had already been arrested from entering the Tenderloin. “Until the city is serious about treating addiction and the root causes of drug use and selling,” said Boudin in a statement, “these recycled, punishment-focused approaches are unlikely to succeed at doing anything more than making headlines.” Home burglaries rose in early 2021 in San Francisco. Homeowners started posting on Twitter videos from their security cameras of people breaking into homes and garages. “When I first moved here we had a car break-in problem,” said Michael Solana, a writer who works for a venture capital fund. “Now we have a home invasion problem. These things are wearing on people.” Boudin attributed the rise of burglaries in San Francisco to the decline of tourism and “people in desperate economic circumstances.” Progressive supervisor Hillary Ronen agreed. “We know that [economic insecurity and inequality] is one of the root causes of property crimes specifically,” she said. But Tom Wolf and others argued that the robberies were, like the shoplifting, done by people seeking money to buy drugs and feed their addictions. “The drugstores have been shoplifted to death and that’s all because of drug use,” said Tom. “I know. I used to do the same thing when I was out there. That’s what you do. You ‘boost.’ And then you go and you sell your stuff down at UN Plaza,” an open-air drug scene. In a May 2021 city supervisors’ meeting, a representative from CVS called San Francisco “the epicenter of organized retail crime in the country” and claimed that 85 percent of the shoplifting is committed by organized theft rings. Police broke up one such ring in October 2020 and recovered $8 million of stolen merchandise. The problem goes beyond property crime. Boudin declined to prosecute two men who went on to kill people. One man had been repeatedly arrested for stealing cars, despite having just been released from prison earlier in the year, and appeared to be abusing meth. On New Year’s Eve, 2020, the man killed two people while driving intoxicated. Police found inside of his car a semiautomatic handgun and twenty-three grams of methamphetamine. On February 4, another intoxicated driver killed a pedestrian in a stolen car. The San Francisco police had arrested him in October 2020 for possessing a stolen car, a tool for stealing cars, and what appeared to be meth. Boudin chose not to pursue charges. In December, the California Highway Patrol arrested the man again for driving a stolen vehicle under the influence. Again he was not prosecuted. The accident victim, an immigrant from Kenya, and his wife had moved to San Francisco two weeks before the fatal crash. “I blame the DA,” said the widow of the victim. The suspect, she said, “was someone who was out in the public who shouldn’t have been in the public. It was completely avoidable.” Tom said he could feel the difference on the streets. “Drug dealing is unabated and it’s not one guy, it’s fifty guys dealing fentanyl and meth,” he said. “And it’s going unabated because the district attorney says, ‘These are the nonviolent, quality-of-life crimes,’ and ‘I’m not going to prosecute them.’” [..] District Attorney Boudin was offering weaker sentences than even defense attorneys were requesting, according to Vicki Westbrook of San Francisco. “There’s a defense attorney who said, ‘It used to be that I would argue for this deal in court with the DA but now I don’t say anything because the DA is going to offer me a deal better than what I would have suggested. Somebody shot up the street with an automatic weapon. The first offer was six months in jail or time served plus two years of probation or something. And then [the DA] said, “How about thirty days in jail?”’” Vicki laughed. “You really can do anything in San Francisco,” she said. “If you do get arrested, chances are you’re going to be out of jail in less than thirty days for damn near everything except maybe killing somebody and maybe even then, too. It’s hard to say at this point.” Taking each of these points individually: Proposition 47 There are two good big studies on the effects of Prop 47, one by Public Policy Institute and one by some UCI criminologists. The PPI study finds that the proposition increased theft and car break-ins by about 10%. The UCI study finds the same, but notes that under different assumptions the effects wouldn’t quite obtain statistical significance. This seems a bit too much like post hoc trying to get rid of an inconvenient effect, plus an effect on the border of statistical significance is different from positively finding no effect. I think a reasonable interpretation is that theft and car break-ins rose about 10% because of the proposition, just as Shellenberger says. Some pro-47 sites note that most states have some limit on how much you to have to shoplift before it’s a felony, and Prop 47 brought California closer to the national average, rather than turning it into an outlier. Chesa Boudin Chesa Boudin took office two months before the COVID pandemic began. Any attempt to separate the effect of Chesa Boudin from the effect of the pandemic is doomed. Shoplifting definitely plummeted when Boudin took office, but that’s because all the stores were closed. Murders definitely rose a little after Boudin took office, but that’s because that was also when the Black Lives Matter protests happened, which demoralized police and led to a so-far-permanent spike in murders nationwide. Percent of criminals caught definitely fell when Boudin took office, but that’s because various aspects of the justice system were closed for COVID (I will grudgingly entertain speculation that a further decrease in arrest rates from 2020 to 2021 may have been a genuine Boudin effect). In the absence of any real way to judge his performance, I think San Fransicko’s points about Boudin are plausible, though speculative. Shoplifting This one is terrible. There’s a surprisingly spirited debate here (some of you may have already read Applied Divinity Studies’ article). The debate is: everyone on the ground in San Francisco - store owners, security guards, customers, random citizens - say that shoplifting has increased massively over the past decade. But statistics mostly say it hasn’t. Source here. This is shoplifting crimes per 100,000 people. Kern County is a deep red county in California (including Bakersfield) that is known for being tough on crime. Against this, seriously, everyone says that shoplifting has obviously increased. I had a patient who worked in shoplifting prevention, he told me - his psychiatrist! Who he had no reason to lie to! - that he was constantly stressed dealing with the shoplifting surge devastating the stores he covered. Here’s the San Francisco subreddit’s response to someone posting the data showing shoplifting hasn’t risen - it’s just a lot of people laughing hysterically. What’s going on? I was able to find a different set of statistics that does seem to show a longer-term increase in shoplifting (source): The very big spike at the end might be a change in reporting by one or two stores - you can find the argument here. But it does look like shoplifting went from about 125 incidents/month in the early 2010s to more like 250/month just before the pandemic. Why is this graph so different from the other one? It looks like the top one came from the Department of Justice, and the bottom one came from SFPD. I’m not sure why these report differently. When you multiply out by 800K people in SF, by 12 months/year, and 30ish days/month, the first graph corresponds to 4 shoplifting incidents per day, and the second to 6. As LouB’s analysis here points out, that seems suspiciously low for a city of 800,000 people where stores are constantly closing because of shoplifting. Maybe off by a factor of a few hundred from what we’d expect. LouB writes: The SFPD report only references shoplifting offenses that required SFPD officers to prepare an incident report. That means either the shoplifter fought security, committed additional crimes, or stole more than $950 worth of items. It’s not that SFPD’s report is erroneous, it’s just not a representative statistic. In a parallel statistic, SFPD only completes incident reports for traffic accidents when there is an injury. Therefore, thousands of noninjury accidents are handled civilly without SFPD reports the same way thousands of shoplifting offenses are handled without reports. An insurance company would not determine premium rates based solely on SFPD incident reports, nor should readers interpret SFPD shoplifting reports as anywhere near the total picture of the shoplifting epidemic in San Francisco. (this would also explain why one or two stores changing their reporting policy can produce a spike equal to everyone else in San Francisco combined) But comparing incident reports from 2010 to incident reports from 2020 should still be apples-to-apples, unless the likelihood of reporting any given incident changed in the meantime. Did it? This news article quotes a San Franciscan who says that when they try to report shoplifting incidents, the cops tell them not to because “it doesn’t make a difference”. If cops say that now more often than they used to, it would make all these statistics meaningless. (Applied Divinity Studies claims to have an argument that shows this can’t be true. It goes something like: if San Francisco was a better place to shoplift than its neighbors - eg Oakland - then shoplifters would leave Oakland to go to San Francisco, and we would see Oakland shoplifting rates falling. Oakland shoplifting rates are falling, but no more so than the rest of the state, so there can’t be increased tolerance for shoplifting in San Francisco. I find this dubious for many reasons. First of all, many of the same reasons shoplifting is up in San Francisco - like Prop 47 or soft-on-crime progressive policies - also apply to Oakland. Second, given that shoplifting fell massively everywhere because of the pandemic, it feels dubious to try to compare different cities; maybe one city had stricter pandemic lockdowns than others. Third, do criminals really shop around for friendly jurisdictions? If so, why are so many crimes like car break-ins, concentrated in “the bad part of town”? Why wouldn’t criminals leave the bad part of town for under-exploited areas with richer residents and less competition? Maybe criminals in fact aren’t very strategic or mobile? Maybe they don’t want to stand in the BART station and then take a half-hour train ride holding a bag of stolen goods?) Maybe a better argument against this being true is how stable the shoplifting rates have been over time. Wouldn’t it be weird if (let’s say) a tripling of the real shoplifting rates was matched by a third-ing of the reporting rates (rather than a halving or a quartering or whatever)? On the other hand, here’s Shellenberger with some helpful data: Some of this is probably because of Proposition 47, which made some forms of shoplifting punishable with citation rather than arrest (but wouldn’t that be a clear discontinuity rather than a gradual trend?) But overall it sure seems like shoplifting is being taken less seriously, which might encourage people to report less. Another statistic I see is that only 2.3% of shoplifting cases result in an arrest; I don’t know how this is different from the graph above with numbers in the 30s; maybe it involves different levels of what makes something a “case”. I accept that the data don’t consistently show a spike in shoplifting. But what’s the alternative? My patient who works in loss prevention in SF stores is lying to me? The nice elderly Chinese man who sold me my last pair of glasses and chatted to me about the rampant shoplifting in his mall was lying? The San Francisco police are lying? Walgreens pretends to be concerned about shoplifting as part of a dastardly plot to close a bunch of stores for no reason? Target and CVS pretend to care about shoplifting as part of a plot to restrict their stores’ opening hours for no reason? Every big store near me has suddenly gotten a security guard at the front as part of some corporate-sponsored jobs program? Maybe the conservative narrative that soft-on-crime San Francisco must be experiencing rising crime rates took on a life of its own. Maybe it infiltrated not just the usual suspects like the SF police unions, but even such supposedly-liberal bastions as the New York Times. Maybe lots of big corporations took advantage of the fake narrative to make unpopular business decisions they were planning on making anyway. And maybe ordinary San Franciscans, confronted with everyone telling them they were in a shoplifting epidemic, started paying more attention to security guards and petty criminals who had always been there, a sort of mass hallucination that gripped everyone in the city. I can’t rule this out. Americans thought crime was rising all throughout the early 2000s, when it was in fact way down. Or maybe some statistics that we already know are off by several orders of magnitude got off by an additional factor of two or so. I think this one is more likely, but I’m genuinely not sure. Other Crime From the Economist: The Center on Juvenile And Criminal Justice puts it even more starkly, arguing that “San Francisco’s ‘Crime Wave’ Is Just One Crime”: This are potentially susceptible to the same reporting bias as shoplifting. So what about homicide? Homicide is practically always reported and investigated, making it a gold standard in crime measurement. (source) Looks pretty good until 2019. I don’t expect to gain useful information post-2020; the pandemic and the post-George-Floyd murder surge will make it impossible to evaluate for local variation. What about compared to other places? For some reason this top 20 table fails to list Washington DC, which should be just before Atlanta. SF doesn’t make the top 20, although its neighbor Oakland does. Probably most murder variation in US cities is explained by percent African-American and maybe percent Borderer; with relatively few people in these groups SF was never in the running. I’m not sure if some abstracted version of the city with all demographic factors adjusted away would have an unusually high murder rate, but at that point it would be pretty distant from any interesting real-world question. You can see the leaderboard for other types of crime here; San Francisco is often in the top ten, but never the top three. As far as I can tell, San Francisco has seen a big spike in car breakins over the past few years, with no clear trend for other property crime, violent crime, or homicides. It’s not an outlier among American cities in any kind of crime. Conclusion of this section: San Fransicko’s specific claims are basically correct, but suggest a medium-term rise in SF crime which is mostly contradicted by the data. These show stable-to-decreasing murder, stable-to-decreasing violent and property crimes other than car break-ins, and large rises in car break-ins only. The data also show stable-to-decreasing shoplifting, but I’m not sure how much to trust them vs. common sense. Honestly, I’m pretty confused here and not sure what to think. Claim 7: Jim Jones (Of Kool-Aid Cult Fame) Used To Be The Chairman Of SF’s Housing Authority Okay, this isn’t really a statistical claim that I can research different perspectives on. Still, it’s so wacky that I couldn’t resist mentioning it in this review. Jim Jones, famous for killing everyone in his Guyana-based Jonestown cult with poisoned Kool-Aid, used to be the SF government’s top guy on homelessness. Shellenberger writes: Jones married and moved first to Northern California and then to San Francisco with his wife to start a church. He called it the People’s Temple. Jones believed he was the leader of a socialist revolution. He warned of nuclear war and claimed black people would be put in concentration camps. He became a hugely charismatic preacher among African Americans, the disaffiliated poor, and young transplants to the city looking for community. Scenes from the era show a remarkably large and diverse congregation smiling and singing. The People’s Temple grew and provided services. Jones cultivated two progressive San Francisco politicians, George Moscone and Willie Brown, and mobilized people to volunteer for their campaigns […] His son and a San Francisco historian believe he stole the mayoral election for Moscone in 1975. Historian David Talbot, founder of the progressive website Salon, points to evidence that Jones committed sufficient voter fraud to account for Moscone’s narrow 4,443-vote margin of victory. “We loaded up all thirteen of our buses with maybe seventy people on each bus, and we had those buses rolling nonstop up and down the coast into San Francisco the day before the election,” said Jones Jr. “Could we have been the force that tipped the election to Moscone? Absolutely! Slam dunk. He only won by four thousand votes.” When federal investigators looked into fraud claims three years later, they discovered that all of the records were missing from the city of San Francisco’s registrar of voters. Jones also boasted of providing Moscone with black women from his congregation for sex. One time Moscone, drunk and “accompanied by a young black woman whom the politician had kindly agreed to drive home,” crashed into another car. Another time, Moscone and Willie Brown “were with a black woman in an alley at two in the morning at some restaurant in North Beach,” said a local bar owner. State legislator “John Burton was part of that gang too. They were all using marijuana and cocaine.” Said Jones Jr., Moscone would “always be there at temple parties with a cocktail in his hand and doing some ass grabbing.” A Temple member overheard Jones speaking to Moscone the day after one of those parties saying, “I want to let you know that the young lady you went off with is underage,” adding, “Now don’t worry, Mayor, we’ll take care of you—because we know that you’ll take care of us.” Afterward, Moscone made Jones the chairman of the powerful San Francisco Housing Commission. Jones cultivated progressives with money and favors. He made large donations to the ACLU, the NAACP, and United Farm Workers. Jones and Moscone met privately with vice presidential candidate Walter Mondale on a campaign plane a few days before the 1976 presidential election, and Mondale praised People’s Temple shortly afterward. Jones met with First Lady Rosalynn Carter several times. Governor Jerry Brown praised Jones. Glide Memorial Church’s Rev. Cecil Williams loved Jones. There is a photo from 1977 of a smiling Williams awarding Jones the church’s “Martin Luther King, Jr. Award.” Jones used his perch as chairman of the Housing Commission to fight for housing for the poor. He tried to use eminent domain to acquire the International Hotel, a single resident occupancy hotel. After a court sided with the hotel’s owner, Jones mobilized seven thousand protesters to picket it. By mid-January 1977, the situation had become heated. There were rumors that protesters inside the building were armed with guns and Molotov cocktails. Jones lost the legal battle in 1977, and the tenants were evicted. But the drama was a publicity victory for Jones, which burnished his image as a white savior. A conservative member of the Board of Supervisors who was defeated in the mayoral election by Moscone accused the new mayor, the San Francisco Chronicle, and the rest of the city establishment of being blind to Jones’s extremism. “There’s no radical plot in San Francisco,” insisted Moscone, in response. “There’s no one I’ve appointed to any city position whom I regard as radical or extremist.” Willie Brown, a powerful state legislator from 1964 to 1995 before becoming mayor in 1996, “seemed oblivious to Jones’ hucksterism and demagoguery,” notes a historian. Brown was master of ceremonies at a dinner for Jones in the fall of 1976 attended by an adulatory crowd of the rich and powerful, including Governor Jerry Brown. “Let me present to you a combination of Martin King, Angela Davis, Albert Einstein . . . Chairman Mao,” he said, to loud applause. And yet Jones was contemptuous of Brown even as Brown did Jones more and more favors. Jones mocked Brown for his designer suits, sports cars, and women. Once, while Brown was addressing the congregation and Jones was seated onstage behind him, Jones flipped his middle finger up to mock him. San Francisco’s establishment stood by Jones even after a California magazine, New West, owned by Rupert Murdoch, published an exposé of Jones’s beatings of Temple members and financial abuses in August 1977. The article was written by a San Francisco Chronicle reporter and was meant for the Chronicle to publish. But the newspaper killed the story because it didn’t want to alienate Jones, whom it viewed as central to its plans to expand the Chronicle’s circulation in the heavily African American Fillmore District. Jones also managed to avoid investigation and prosecution in part by getting the district attorney to hire as deputy district attorney Jones’s longtime attorney and confidant. Progressives defended Jones against the New West article. At a rally in the summer of 1977, Willie Brown said, “When somebody like Jim Jones comes on the scene, that absolutely scares the hell out of most everybody occupying positions of power in the system.” Angela Davis sent a radio message broadcast over the cult’s compound, Jonestown, in Guyana. “I know you’re in a very difficult situation right now,” she said, “and there is a very profound conspiracy designed to destroy the contributions which you have made to the struggle.” After visiting Jonestown, the attorney to the Black Panthers said, “I have seen paradise.” Harvey Milk, too, was tarnished by his association with Jones. In the fall of 1977, Milk wrote to President Carter’s secretary of health, education, and welfare requesting that Social Security checks be sent to elderly Temple members in Guyana. “People’s Temple,” wrote Milk, has “established a beautiful retirement community in Guyana.” In truth, the cult was disintegrating. Jones separated families and lovers, pitted relatives against each other, and forced neighbors to inform on each other. Jones sent people who violated the rules to solitary confinement in “the Box,” an underground cubicle where people were held as prisoners for days on end. Others were drugged. Progressives who had spent thirty years fighting to close prisons and mental hospitals found themselves praising a man who had reproduced their worst practices. In November 1978 a Bay Area congressman flew to Guyana to investigate human rights violations at Jonestown with NBC News. Jones gave the delegation a formal reception at Jonestown. A Temple member surreptitiously passed a note to one of the delegation members, saying he and another member wanted to escape. They fled the next day after a Temple member tried to stab the congressman. Jones didn’t prevent them from leaving but then sent gunmen to fire machine guns at the delegation at the airport, killing the congressman and four others. A few hours later, 907 inhabitants of Jonestown drank Flavor Aid laced with cyanide and died. Two-thirds of the victims were African American and one-third were children. Jones had told them that if they didn’t drink it they would be killed by invading soldiers from a shadowy global military conspiracy intent on imposing fascism and torturing children. As people started crying in grief, Jones scolded them. “Stop these hysterics,” he said. “This is not the way for people who are socialists or communists to die.” Jones’s wife protested the murder of children and had to be forcibly restrained. “We didn’t commit suicide,” said Jones in a tape recording, “we committed an act of revolutionary suicide protesting the conditions of an inhumane world.” Few were as stained by Jonestown as Willie Brown and George Moscone. “Even as the bloated bodies of the dead were removed from the jungle and the wounded were airlifted by the U.S. Air Force to hospitals in the United States,” wrote a historian, “Brown said he had ‘no regrets’ over his association with Jones.” They repeatedly disavowed responsibility. Said Moscone, “it’s clear that if there was a sinister plan, then we were taken in. But I’m not taking any responsibility. It’s not mine to shoulder.” This is Shellenberger at his best: telling us crazy stories from the recesses of San Francisco history, maybe kind of spinning the narration in a way that makes all progressives seem guilty by association, but with the tale itself so gripping that it’s hard to be mad. And Jones wasn’t alone. This was the golden age of San Francisco cults, when (Shellenberger tells us) “more than half of all high school students in the San Francisco Bay Area reported at least one recruiting attempt by a cult member, and 40 percent reported at least three contacts.” This chapter of SF history came to an end in 1978, when Dan White, who had just resigned from San Francisco’s Board Of Supervisors (ie City Council) entered City Hall through a window and assassinated Mayor Moscone and fellow Supervisor Harvey Milk, then successfully got charges reduced to manslaughter through a legal manuever that has gone down in history as “the Twinkie Defense” (realistically the defense was that he was depressed, but reporters seized on a comment that implied it was because he ate too many Twinkies). Everything about 1970s San Francisco was like this. With the Mayor and his right-hand-man both dead, San Francisco leadership ended up in the hands of previously second-tier politician Dianne Feinstein. Feinstein was what passed for a moderate in 1970s SF (which meant she had been targeted for assassination by various left-wing groups - she survived when a bomb left on her windowsill failed to explode). In Shellenberger’s telling, she managed to clean up some of the mess and restore a semblance of normalcy. San Francisco never forgave her. Moscone - voting fraud committer, underage sex enjoyer, and Jim Jones’ bff - is beloved as a martyr in today’s SF, but (the book points out) Feinstein is so loathed that in 2021 the Board of Education voted to rename Dianne Feinstein Elementary School. The Moscone Center is 2 million square feet and can fit about 10,000 people. Not to be confused with the Moscone Recreation Center, Moscone Station, or Moscone Elementary School. Meanwhile, all Dianne Feinstein got was one lousy elementary school and the Tithonus package of eternal life without eternal youth. Claim 8: The Intolerant Left Shuts Down Debate On These Issues Another one that’s probably hard to do a randomized controlled trial on. You could probably predict that this one was coming - it’s a necessary narrative beat in this genre of book. I think this beat is good. My impression is that people who aren’t themselves public figures disagreeing with left-wing ideas still don’t understand how scary it is and how much hate you get. Maybe now that 2/3s of every political essay written over the past five years is about this topic, people will finally get it through their thick skulls that it exists and is bad. I would also note that “traumatizing the sorts of people who write popular books about politics, in a such a way that they feel compelled as a sort of self-therapy to write page after page telling readers how angry they should be at you and your whole coalition” isn’t great political praxis. I would like people to figure this out and stop doing it. Anyway, Shellenberger is doing his part in this effort: In 2001, the San Francisco Coalition on Homelessness wheat-pasted posters of a fake front-page San Francisco Chronicle across town. Just beneath the masthead a large headline read “Fuck the Homeless!” right above a picture of San Francisco mayor Willie Brown laughing. Below his photo was the headline “Save the Tourists.” Progressives level the same charges at people thirty years later. “Because of some of the stuff I say,” said a community activist in Seattle’s historically black Capitol Hill neighborhood, “people say, ‘Oh, she’s not for them.’ But I have a heart for homeless and mentally ill. Most of my family works with the mentally ill.” Noted a Chronicle journalist in 2017, “Inevitably, homeless advocates and others will say, ‘You’re not compassionate,’” in response to stories about homeless encampments. “They called me a racist,” said Tom. “They accused me, a guy who used to be homeless, of demonizing the homeless, because I’m asking for accountability.” I found myself similarly accused. In 2019, after I published an article for Forbes about the homeless crisis, a progressive homeless activist accused me on Twitter of having written my article to “make money off of a fear tactic” of “fueling hatred [and] even increasing violence against homeless people.” After I asked the former San Francisco supervisor for the Tenderloin neighborhood, former mayoral candidate Jane Kim, how such a progressive city ended up with so much suffering, she said, “My concern, Michael, just to be very honest, is that when that kind of messaging goes out, violence against people who are unhoused goes up.” […] I soon discovered in my research that I was hardly the first person that progressive elected officials and homelessness advocates had accused of fomenting violence against unhoused people. Many others had been criticized for far worse over the years, including San Francisco’s highest elected officials. “The criticism [by progressive homelessness advocates] was heavy, political and personal,” wrote former mayor Willie Brown in his 2008 memoir. “People accused me of abandoning the problem when I was working daily to try and get a solution going. It was brutal. . . . I had become demonized, and my own efforts belittled.” It is notable that the result of such personal attacks is to frighten off people seeking to change, and perhaps improve, the situation. “The problem” of homelessness, concluded Mayor Brown within nine months of entering office, “may not be solvable.” And [Quoting Chris Rufo]. “The chief of psychiatry in a public hospital system in one of the largest California cities told me, ‘I know for a fact, and all of my colleagues know, that what we actually need to deal with the problem in the biggest cities in California is long-term residential secure psychiatric care. But I can’t say that publicly because I would be disemboweled by the activist left. My job would be in jeopardy. My reputation would be in jeopardy. My whole life would get turned upside down for even broaching the subject of expanding secure mental health facilities and compulsory mental health treatment.’ And I said, ‘So what’s the solution?’ and this person said, ‘We muddle through.’” And: In San Francisco, radical left activists protested [African-American] Mayor London Breed in front of her home. Breed said the protesters were “all white people. But that didn’t bother me as much as the taunting of me coming outside with firework torches in their hands looking like what used to happen when the KKK would show up to black people’s houses to burn their houses down.” While I was reading the book, I came across this tweet, which suggests that being unimpressed with SF’s lefty homeless activist scene is not limited to Michael Shellenberger: Claim 9: European Cities Like Amsterdam Successfully Solved Their Own Drug And Homelessness Problems By Doing The Opposite Of SF Shellenberger bases his plan to solve these problems on ideas that he says were pioneered in Amsterdam and spread to other European cities. In the 1980s, Amsterdam had the kinds of problems San Francisco deals with now: open-air drug markets, overdose deaths, homelessness, and crime. But in the 90s, they admitted they had a problem and took decisive action: What’s the secret?” I asked him. “Amsterdam has decriminalized marijuana and many other drugs but I haven’t seen any homeless. What is San Francisco doing wrong?” Rene said that in the 1980s, the Zeedijk neighborhood in Amsterdam was a lot like the Tenderloin [the worst part of San Francisco] today. There was open-air drug use, particularly of heroin, and needles strewn about, as well as crime. People started to flee the neighborhood, worsening its slum conditions. Homeless people squatted in abandoned buildings. “We had ghettos where it was not safe to go,” said Rene, who started working in the neighborhood as a nurse in 1985. It was considered a “no go” zone. “We had a lot of people from abroad who came to Amsterdam because our heroin was so good. But our heroin was so good that they died from it.” At first the city tried a “helping approach” exclusively, offering addicts clean needles, methadone, and other forms of help without any law enforcement, but it didn’t work. “In the eighties we just wanted to help people,” said Rene. “We started with methadone programs and medical treatment. We did a lot of work without much of a carrot and a stick. It was really a disappointment. They just used the methadone to stay addicted. They dealt drugs and committed other crimes. They lied and cheated about it. We were just supporting a different kind of market. We had to learn the hard way [...] The Amsterdam City Council asked the Amsterdam Municipal Health Service to develop a strategy to deal with “unmotivated drug users”...The police broke up the open-air drug scene and health workers were on hand to offer methadone, treatment, and shelter. The police broke up gatherings of more than four or five users, but did not treat personal and private use as a crime. Officers ticketed violators, and if users did not pay their fines, which was frequent, the courts ordered arrests, and sentenced individuals to follow a treatment plan or face incarceration. “For every individual homeless person, we make a plan,” said Rene. “We made tens of thousands of those plans.” Plans are overseen by a caseworker and a team that may include a psychiatrist, shelter provider, service provider, judge, employer, parole officer, and police officer. “You need people in the police and health department working together,” he said. What Amsterdam did was the same as other major European cities. Lisbon, Frankfurt, Vienna, and Zurich all dealt with their open-air drug markets, using a combination of law enforcement and social services. Crucially, Amsterdam and other European cities prevented services from being concentrated in a single neighborhood, since their concentration often enables an open-air drug scene to thrive [...] The efforts worked. “We had several thousand people who were addicted to heroin in the eighties and nineties,” said Rene. “Many died. Today we have four or five hundred people addicted to methadone. And we have about 120 in Amsterdam who we supply heroin to on a medical basis because methadone doesn’t work for them. They have to use heroin.” The Amsterdam strategy goes something like: Break up open-air drug markets and anywhere that more than 4-5 drug users are congregating. Yes, people can just use their drugs in private, but this is legitimately better. Open-air markets normalize drugs with their blatantness, and make it hard to quit for the same reason it’s hard to diet if your partner leaves boxes of donuts out in the house every day.
Inline links: a proper randomized study, Somers, Moniruzzaman and Palepu, Padgett et al, Kirst et al, Milby, a $14 billion budget, This article, talk about, another article about people objecting to, boarding houses, Politico, has completed only 700 units, Considerations On Cost Disease, this comment, An article, https://substackcdn.com/image/fetch/$s_!4wi2!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F00f02bfe-c696-415d-ba80-5edb997021cb_809x487.png, survey, This app, this webpage, this site, many people, among the strongest proponents of both, these numbers, here, https://substackcdn.com/image/fetch/$s_!msoV!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F8b34d51f-d6ed-43ee-a069-5e74fe75c421_1812x1102.png, an anti-drug Australian think tank, https://substackcdn.com/image/fetch/$s_!CN2E!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F85656c06-22bc-4076-80f0-b7a9bd4aa0d3_574x331.png, A Resounding Success Or Disastrous Failure: Re-examining The Interpretation Of Evidence On The Portuguese Decriminalisation Of Illicit Drugs, https://substackcdn.com/image/fetch/$s_!VvrE!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F2341944a-388d-4da9-9788-8474567b83fc_540x737.png, Ed West, Public Policy Institute, UCI criminologists, Applied Divinity Studies’ article, https://substackcdn.com/image/fetch/$s_!aTNC!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2Fa27aeb21-ed87-4e67-b82c-b3ceecee7082_500x238.png, here, Here’s the San Francisco subreddit’s response, https://substackcdn.com/image/fetch/$s_!_NL6!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2Fcf7dc478-45d3-487d-8c29-8bc7cdf182dd_2400x1500.png, LouB’s analysis here, This news article, only 2.3% of shoplifting cases result in an arrest, New York Times, the Economist, https://substackcdn.com/image/fetch/$s_!58I3!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2Fc63dc7bc-1f8e-49fd-9c68-61c85278d69e_608x662.png, San Francisco’s ‘Crime Wave’ Is Just One Crime, https://substackcdn.com/image/fetch/$s_!h17s!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F956c0917-2a9b-4ff7-a08e-6aee5030583a_590x376.png, https://substackcdn.com/image/fetch/$s_!TkFS!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F5c5faa01-ac22-48a2-96fe-47efb6f52514_616x334.png, source, https://substackcdn.com/image/fetch/$s_!Bg2w!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F18e49c63-16ba-4878-96e6-aec12d7c5953_481x667.png, percent African-American, percent Borderer, here, the Twinkie Defense, https://substackcdn.com/image/fetch/$s_!8wK3!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F683b9754-f663-47ad-88f5-aa99bc208ec8_1401x622.jpeg, https://twitter.com/weheartprez/status/1526983899309432832
Peronism1 mentions across 1 issues

Peronism is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between February 09, 2023 and February 09, 2023. The archive places it in contexts such as "These conflicts created the fertile soil for the identity politics half of Peronism". It most often appears alongside @moritheil, ACX Prediction Contest, Adam Tooze.

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Peronism
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1
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1
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February 09, 2023
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February 09, 2023
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Links For February 2023
February 09, 2023 · Original source
34: Etirabys: In 1910, Argentina was the 7th richest country in the world. Starting around 1930, it flatlined harder than anyone had ever flatlined before, until now it is only about average for South America, itself a relatively mediocre region. Why? Etirabys brings up fifty years of incessant coups and countercoups centered upon Juan Peron and his opponents. @moritheil clarifies two additional points: first, "though the Peronists are often described as proto-fascist, First Lady Eva would in modern terms be called a social justice warrior . . . Argentina discovered identity politics decades before the US did". This is probably not the sentence you want to read about your country’s governing party if you’re hoping for economic growth. Second, during the period involved, Argentina accepted an extraordinary number of immigrants, especially from Italy (60% of Argentines are now of at least partial Italian descent), reaching percent-immigrant levels more than double the US at its peak. Those immigrants were an awkward combination of Jews and other refugees fleeing Europe just before World War II, and defeated Nazis fleeing Europe just after World War II. These conflicts created the fertile soil for the identity politics half of Peronism. Garrett Jones says that his new book on immigration has a chapter on this. Related quote: “There are four types of economies: developed, developing, Japan, and Argentina”.
Inline links: Etirabys, clarifies two additional points, Garrett Jones says, Related quote:
Perry Preschool1 mentions across 1 issues

Perry Preschool is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between September 04, 2025 and September 04, 2025. The archive places it in contexts such as "downstream of Perry Preschool style dreams". It most often appears alongside 80,000 Hours, abundance liberalism, Afghanistan.

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Perry Preschool
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1
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1
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September 04, 2025
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September 04, 2025
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Links For September 2025
September 04, 2025 · Original source
I tried to see if AI could do this, and it did something that technically met the requirements but had zero artistic merit - using a lot of words like “nowhere” and “outside” in one, then separating them out to “no where” and “out side” in the other. I didn’t invest much energy in creating a clever prompt telling it not to do that, so feel free to report if you get better success. 52: New study claims consultants are actually good, at least for profits: "We find positive effects on labor productivity of 3.6% over five years, driven by modest employment reductions alongside stable or growing revenue" 53: A Polish team tries to test Peter Turchin’s equations for predicting political unrest on recent Polish history, has to make some changes but claims mostly positive results. 54: New big multi-author Substack, The Argument, trying to be a sort of center-left version of the model pioneered by The Free Press and other high-production-value ideological Substack properties. Excited to see Kelsey Piper is involved, and she starts off strong with a post on the latest round of First World basic income studies, which find few positive effects. This is surprising, because recipients didn’t waste the money on alcohol or gambling or anything - they paid down debt and got useful goods. Still, it didn’t even affect things that should have been obvious, like stress level. It’s not even clear that amounts of money large enough to help with rent made homeless people more likely to get houses! Matt Bruenig criticizes the article, accusing Kelsey’s studies of being downstream of Perry Preschool style dreams that exactly the right welfare program will have massively compounding effects that cut poverty out at the root and turn everyone into elite human capital; he thinks giving people money won’t do this, but it will increase equality and give the poor better lives. I assume he’s not a strong hereditarian, but his argument makes even more sense from that perspective, and I’ve certainly criticized dumb outcome measures like infant brain waves which we have only tenuous reasons to think are related to anything we care about. But Kelsey reasonably responds that the outcome measures she’s talking about include stress level and life satisfaction. To defuse this critique, Bruenig either has to argue that our construct “life satisfaction” doesn’t really measure whether someone’s life is satisfactory, or else claim that giving poor people satisfactory lives isn’t really what we’re going for - which I think would require more explanation on his part. There’s some further (impressively acrimonious) debate on X, but I don’t see anything that addresses my core concern. GiveDirectly, a charity involved in basic income experiments, has a presponse here; they say that some studies are positive, and that the ones that aren’t might have tried too little cash to matter, or been confounded by COVID making everything worse. They also point out that basic income is harder to study than traditional programs like giving people housing, because if you’re giving housing you can measure housing-related outcomes directly and have a pretty good chance of getting enough statistical power to find them, but since everyone spends cash on different things, the positive effects might be scattered across many different outcomes (and therefore too small to reach significance on each). Everyone involved in this debate wants to emphasize that the poor results are for First World studies only, and that studies continue to show large benefits to giving cash in the developing world. 55: Related: I was less impressed by The Argument’s first foray into housing policy, which follows an all-too-familiar pattern: Some people say they don’t like noise and disorder and try to make rules against it in their apartments.
Inline links: New study claims consultants are actually good, tries to test Peter Turchin’s equations for predicting political unrest on recent Polish history, The Argument, a post on the latest round of First World basic income studies, criticizes the article, infant brain waves, debate on X, has a presponse here, first foray into housing policy
Persephone1 mentions across 1 issues

Persephone is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between August 26, 2022 and August 26, 2022. The archive places it in contexts such as "Persephone’s mom". It most often appears alongside 1917, aesthetics, American.

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Persephone
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1
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1
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August 26, 2022
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August 26, 2022
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Your Book Review: Kora In Hell
August 26, 2022 · Original source
William Carlos Williams attributes the title to his friend/rival Ezra Pound, mythological references’ number one fanboy. Kora is a parallel figure to Persephone or Proserpina, the Spring captured and taken to Hades by Hades himself. Persephone as a plant goddess and her mother Demeter were the central figures of the Eleusinian Mysteries, which promised the initiated a groovy afterlife glimpsed at by psychedelic shrooms. And Kora means maiden. Ancient Greeks called her that either because she was like Voldemort, and you were apotropaically not supposed to say her true name because this is a Mystery Cult, damn it. Keeps some of the mystery. Or because she in a way represents all of the maidens, everywhere. So, in that sense, Kora in Hell alludes to the multitude of suffering young women Williams met while working as a doctor, assisting in 1917 style home labors, and, because WWI was going on at the time and doctors were extremely scarce, as a local police surgeon. Conditions were dire:
So yet another interpretation of the title is that WCW is not the Spring taken to Hades. WCW is Demeter, Persephone’s mom, who is desperately moving Heaven and Earth to get her daughter, the American poets of the future, back from the greedy claws of the God of the Underworld, personified in this allegory by the author of Old Possum's Book of Practical Cats.
PERSONAL1 mentions across 1 issues

PERSONAL is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between September 29, 2022 and September 29, 2022. The archive places it in contexts such as "individual human beings should live their own lives exercising their PERSONAL freewill & flow". It most often appears alongside 1 Kings 10-11, 2008 Democratic National Convention, Adam Scheffer.

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PERSONAL
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1
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1
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September 29, 2022
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September 29, 2022
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Universe-Hopping Through Substack
September 29, 2022 · Original source
Like an obscure indie band, the Music section of Substack is hard to get into. Most blogs are either paywalled, just post music and videos without any text, or the diaries of famous musicians - which could be interesting, if they would ever say anything more personally revelatory than “I AM ON TOUR RIGHT NOW, YOU SHOULD COME TO MY CONCERT”. I was finally able to find The Honest Broker by Ted Gioia, at the cost of probably missing out on some really exotic parallel universes too weird for me to relate to. Honest Broker discusses the music industry and history of music.
Inline links: The Honest Broker
It seems like an unfair battle. How can music ever be more powerful than logic? But Plato—and the other leading ancients who laid the groundwork for our rational and algorithmic society—feared music for a good reason. They saw the hypnotic effect of the epic and lyric singers on the masses. For centuries, people learned life skills from songs. They preserved history, culture, and the entire mythos with songs. They tapped into their own deepest emotions with songs. They celebrated every life milestone and ritual with songs. They reached out to the gods themselves with songs. Above all, they used this music to secure personal autonomy and what today we would call human rights. So we should not be surprised that Plato, Aristotle and the other originators of Western rationalism had to displace this dominant worldview of their ancestors—mythic, magical, musical—in order for them to create a more rigorous, disciplined, and analytical society. They won that battle, and we live with the consequences today in our algorithm-driven culture.
I believe individual human beings should live their own lives exercising their PERSONAL freewill & flow in word & deed with the Material World via Our Creator’s Natural Law as they honor their personal Nature. (DNA)
personal computer1 mentions across 1 issues

personal computer is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between May 15, 2024 and May 15, 2024. The archive places it in contexts such as "New technologies like the personal computer, the Internet, and the Human Genome Project were inspiring"; "New technologies like the personal computer". It most often appears alongside @the_megabase, A Pan-Species Welfare State, ACX Grantees.

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personal computer
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1
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1
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May 15, 2024
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May 15, 2024
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Profile: The Far Out Initiative
May 15, 2024 · Original source
Turn-of-the-21st-century Oxford was an exciting place. Derek Parfit was leading a renaissance in utilitarian thought. New technologies like the personal computer, the Internet, and the Human Genome Project were inspiring a new generation of transhumanists. Out of this milieu, philosophers like Nick Bostrom, Will MacAskill, and Toby Ord were laying the groundwork for what would become the rationalist and effective altruist movements. Utilitarians, they argued, were charged with relieving the suffering of the world as quickly and effectively as possible. Technology offered new opportunities to do this at scale. This could be ending poverty and curing diseases (if you were well-grounded in the present moment) or creating a superintelligence to lead us to a post-scarcity future (if you were feeling more ambitious).
PET1 mentions across 1 issues

PET is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between July 16, 2024 and July 16, 2024. The archive places it in contexts such as "positron emission tomography (PET, that’s the one where you inject a radioactive tracer)". It most often appears alongside auditory cortex, Big Bang, cerebellum.

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PET
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1
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1
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July 16, 2024
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July 16, 2024
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Consciousness As Recursive Reflections
July 16, 2024 · Original source
There is another new approach that also improves the intersection of spatial and temporal resolution. It combines the millimeter-scale spatial resolution of simultaneous fMRI and positron emission tomography (PET, that’s the one where you inject a radioactive tracer) with improvements of temporal resolution down to as little as 12 seconds using clever tweaks to radiotracer delivery. Currently that temporal resolution is still too long for most thoughts, but there’s ongoing development and the physical limits to improving the temporal resolution of this method are not yet established. This might end up superior to EEG source analysis, especially for studying the center of the brain.
Inline links: temporal resolution down to as little as 12 seconds
Peter Principle1 mentions across 1 issues

Peter Principle is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between May 10, 2022 and May 10, 2022. The archive places it in contexts such as "In 1969, Laurence Peter proposed the Peter Principle"; "Laurence Peter proposed the Peter Principle". It most often appears alongside A Few Good Men, Adolf Eichmann, Akron.

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Peter Principle
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1
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1
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May 10, 2022
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May 10, 2022
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Book Review: The Gervais Principle
May 10, 2022 · Original source
In 1969, Laurence Peter proposed the Peter Principle: “everyone gets promoted to the level of their incompetence”. That is, if you’re great at your job, you keep getting promoted, until you reach a level where you’re bad at it, then stay there. This also got oddly philosophical for a business book.
Inline links: Peter Principle
In 1969, Laurence Peter proposed the Peter Principle: “everyone gets promoted to the level of their incompetence”. That is, if you’re great at your job, you keep getting promoted, until you reach a level where you’re bad at it, then stay there. This also got oddly philosophical for a business book. In 1995, Scott Adams countered with the even more cynical Dilbert Principle: “companies tend to systematically promote incompetent employees to management to get them out of the workflow”.
Inline links: Peter Principle, Dilbert Principle
Petersonites1 mentions across 1 issues

Petersonites is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between February 20, 2025 and February 20, 2025. The archive places it in contexts such as "St. Philip of Lighthaven was captured by the Petersonites"; "While the Petersonites were busy trying to figure out whether he even disagreed with them". It most often appears alongside AI corrigibility, AI lab, AI Safety.

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Petersonites
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February 20, 2025
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Lives Of The Rationalist Saints
February 20, 2025 · Original source
St. Philip of Lighthaven was captured by the Petersonites, who demanded that he profess that, although God might not exist, we should believe in Him anyway for pragmatic reasons. Philip retorted that he had a 16% probability in God's existence, and a 75% chance that believing in God would make the average person better off, but that credence in the latter belief should not affect credence in the former. While the Petersonites were busy trying to figure out whether he even disagreed with them or not, he snuck outside, opened the gates to their fortress, and sent a signal to the Rationalist army, who fell upon them and destroyed them.
petunias1 mentions across 1 issues

petunias is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between February 24, 2021 and February 24, 2021. The archive places it in contexts such as "Declassed also are ... petunias". It most often appears alongside 1950s, 1980s, 1983.

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petunias
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February 24, 2021
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February 24, 2021
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Book Review: Fussell On Class
February 24, 2021 · Original source
Anyone imagining that just any sort of flowers can be presented in the front of a house without status jeopardy would be wrong. Upper-middle-class flowers are rhododendrons, tiger lilies, amaryllis, columbine, clematis, and roses, except for bright-red ones. One way to learn which flowers are vulgar is to notice the varieties favored on Sunday-morning TV religious programs like Rex Humbard's or Robert Schuller's. There you will see primarily geraniums (red are lower than pink), poinsettias, and chrysanthemums, and you will know instantly, without even attending to the quality of the discourse, that you are looking at a high-prole setup. Other prole flowers include anything too vividly red, like red tulips. Declassed also are phlox, zinnias, salvia, gladioli, begonias, dahlias, fuchsias, and petunias. Members of the middle class will sometimes hope to mitigate the vulgarity of bright-red flowers by planting them in a rotting wheelbarrow or rowboat displayed on the front lawn, but seldom with success.
PGS deviations1 mentions across 1 issues

PGS deviations is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between January 16, 2025 and January 16, 2025. The archive places it in contexts such as "he actually meant PGS deviations, each of which was about 3-4 IQ points". It most often appears alongside Afghanistan, Africa, African small-plot subsistence agriculture.

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PGS deviations
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January 16, 2025
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Highlights From The Comments On Lynn And IQ
January 16, 2025 · Original source
First, he corrected my misconception about Reich on ancient European cognitive evolution. Reich had said that pre-agriculture Europeans were “2-3 standard deviations” below moderns. I had interpreted that as IQ deviations of 15 points, making them genetic IQ 55-70, which would have been pretty crazy. Stone tells me he actually meant PGS deviations, each of which was about 3-4 IQ points, so he’s claiming that pre-agriculture Europeans had genetic IQ of 90 (they probably also had lower IQ for environmental reasons).,
Pharizaioi1 mentions across 1 issues

Pharizaioi is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between September 19, 2023 and September 19, 2023. The archive places it in contexts such as "the nations of ... Pharizaioi". It most often appears alongside 15th century Sicilian manuscript, Agrimardio, Aigeis.

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Pharizaioi
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September 19, 2023
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Book Review: The Alexander Romance
September 19, 2023 · Original source
In case you’re wondering, in addition to Gog and Magog, this saved us from the nations of “Anougeis, Aigeis, Exenach, Diphar, Photinaioi, Pharizaioi, Zarmatianoi, Chachonioio, Agrimardio, Anouphagoi, Tharbaioi, Alans, Physolonikaioi, Saltarioi, and the rest.” I recognize two of these: the Sarmatians and the Alans - as real steppe tribes. The others are probably imaginary steppe tribes meant to represent how big and scary the steppe was in the Mediterranean imagination.
Pharma1 mentions across 1 issues

Pharma is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between November 17, 2021 and November 17, 2021. The archive places it in contexts such as "Pharma companies want you to use more expensive patented drugs instead". It most often appears alongside ACE-2 receptor, ACSH, Ahmed et al.

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Pharma
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Ivermectin: Much More Than You Wanted To Know
November 17, 2021 · Original source
…looks very impressive, in terms of the experimental group doing better than the control, except that they don’t specify whether it was before the trial or after it, and at least one online commentator thinks it might have been before, in which case it’s only impressive how thoroughly they failed to randomize their groups. Overall I don’t feel bad throwing this study out. I hope it one day succeeds in returning to its home planet. Lopez-Medina et al: Colombian RCT. 200 patients took ivermectin, another 200 took placebo. They originally worried the placebo might taste different than real ivermectin, then solved this by replacing it with a different placebo, which is a pretty high level of conscientiousness. Primary outcome was originally percent of patients whose symptoms worsened by two points, as rated on a complicated symptom scale when a researcher asked them over the phone. Halfway through the study, they realized nobody was worsening that much, so they changed the primary outcome to time until symptoms got better, as measured by the scale. In the ivermectin group, symptoms improved that much after 10 days; in the placebo group, after 12, p = 0.53. By the end of the study, symptoms had improved in 82% of ivermectin users and 79% of controls, also insignificant. 4 patients in the ivermectin group needed to be hospitalized compared to 6 in the placebo group, again insignificant. This study is bigger than most of the other RCTs, and more polished in terms of how many spelling errors, photographs of computer screens, etc, it contains. It was published in JAMA, one of the most prestigious US medical journals, as opposed to the crappy nth-tier journals most of the others have been in. When people say things like “sure, a lot of small studies show good results for ivermectin, but the bigger and more professional trials don’t”, this is one of the two big professional trials they’re talking about. Ivermectin proponents make some good arguments against it. In order to get as big as it did, Lopez-Medina had to compromise on rigor. Its outcome is how people self-score their symptoms on a hokey scale in a phone interview, instead of viral load or PCR results or anything like that. Still, this is basically what we want, right? In the end, we want people to feel better and less sick, not to get good scores on PCR tests. Also, it changed its primary outcome halfway through; isn’t that bad? I think maybe not; the reason we want a preregistered primary outcome is so that you don’t change halfway through to whatever outcome shows the results you want. The researchers in this study did a good job explaining why they changed their outcome, the change makes sense, and their original outcome would also have shown ivermectin not working (albeit less accurately and effectively). I don’t know of any evidence that they knew (or suspected) final results when switching to this new outcome, and it seems like the most reasonable new outcome to switch to. Finally, their original placebo tasted different from ivermectin (though they switched halfway through). This is one of the few studies where I actually care about placebo, because people are self-rating their symptoms. But realistically most of these people don’t know what ivermectin is supposed to taste like. Also, they did a re-analysis and found there was no difference between the people who got the old placebo and the new one. I’m making a big deal of this because ivmmeta.com - the really impressive meta-analysis site I’ve been going off of - puts a special warning letter underneath their discussion of this study, urging us not to trust it. They don’t do this for any of the other ones we’ve addressed so far - not the one by the guy whose other studies were all frauds, not the one where 50% of 21 people had headaches, not the unrandomized one where the groups were completely different before the experiment started, not even the one by the guy accused of crimes against humanity. Only this one. This makes me a lot less charitable to ivmmeta than I would otherwise be; I think it’s hard to choose this particular warning letter strategy out of well-intentioned commitment to truth. They just really don’t like this big study that shows ivermectin doesn’t work. Also, the warning itself irritates me, and includes paragraphs like: RCTs have a fundamental bias against finding an effect for interventions that are widely available — patients that believe they need treatment are more likely to decline participation and take the intervention [Yeh], i.e., RCTs are more likely to enroll low-risk participants that do not need treatment to recover (this does not apply to the typical pharmaceutical trial of a new drug that is otherwise unavailable). This trial was run in a community where ivermectin was available OTC and very widely known and used. Nobody else worries about this, and there are a million biases that non-randomized studies have that would be super-relevant when discussing those, but somehow when they’re pro-ivermectin the site forgets to be this thorough. I think a better pro-ivermectin response to this study is to point out that all the trends support ivermectin. Symptoms took 10 days to resolve in the ivermectin group vs. 12 in placebo; 4 ivermectin patients were hospitalized vs. 6 placebo patients, etc. Just say that this was an unusually noisy trial because of the self-report methodology, and you’re confident that these small differences will add up to significance when you put them into a meta-analysis. Roy et al: We’re back in East India, and back to non-randomized trials. 56 patients were retrospectively examined; some had been given ivermectin + doxycycline, others hydroxychloroquine, other azithromycin, and others symptomatic treatment only. We don’t get any meaningful information about how this worked, but we are told that they did not differ in “clinical well-being reporting onset timing”. Whatever. Chahla et al: The first of many Argentine trials. 110 patients received medium-dose ivermectin; 144 were kept as a control (no placebo). This was “cluster randomized”, which means they randomize different health centers to either give the experimental drug or not. This is worse than regular randomization, because there could be differences between these health centers (eg one might have better doctors who otherwise give better treatment, one might be in the poor part of town and have sicker patients, etc). They checked to see if there were any differences between the groups, and it sure looks like there were (the experimental group had twice as many obese people as the controls), but as per them, these differences were not statistically significant. Note that if this did make a difference, it would presumably make ivermectin look worse, not better. The primary outcome was given as “increase discharge from outpatient care with COVID-19 mild disease”. This favored the treatment; only 2/110 patients in the ivermectin group failed to be discharged, compared to 20 patients in the control group. But, uh, these were at different medical centers. Can’t different medical centers just have different discharge policies? One discharges you as soon as you seem to be getting better, the other waits to really make sure? This is an utterly crap endpoint to do a cluster randomized controlled trial on. If you’re going to do cRCT, which is never a great idea, you should be using some extremely objective endpoint that doctors and clinic administrators can’t possibly affect, like viral load according to some third-party laboratory, using the same third-party laboratory for both clinics. This is such a bad idea that I can’t help worrying I’m missing or misunderstanding something. If not, this is dumb and bad and should be ignored. Mourya et al: We’re back in India. This is a nonrandomized study comparing 50 patients given ivermectin to 50 patients given hydroxychloroquine. No primary outcome was named, but they focus on PCR negativity. Only 6% of patients in the hydroxychloroquine group were negative, compared to 90% of patients in the ivermectin group! On what day did they do the test? Uh, kind of random, and they admit that “in [the hydroxychloroquine group], mean time difference from the date of initiation of treatment and second test was significantly longer (7.24±2.75 days) as compared to 5.22±1.21 days in [the ivermectin group] (p=0.021).” Since they assessed these groups at different times, we shouldn’t draw any conclusions from them getting different results. Except that as far as I can tell this should handicap ivermectin, making it especially impressive that it did better. But also, the ivermectin group was made mostly of people who had been asymptomatic at the beginning (70%), and the hydroxychloroquine group had almost no asymptomatic cases (8%) . They were giving the ivermectin to healthy people and the hydroxychloroquine to sick people! They admit deep in the discussion that this “may be a confounding factor”. So basically they got totally different groups of people, tested them at totally different times, and the two sets of test results differed. So what? So this is why normal people do RCTs instead of whatever the heck this is, that’s what. Loue et al: …this one isn’t going to be an RCT either. Loue tells a story about a cluster of COVID cases at the French nursing home where he works. He asked people if they wanted to try ivermectin; 10 did and 15 didn’t. 1 ivermectin patient died, compared to 5 non-ivermectin patients. The non-ivermectin group looked a bit sicker than the ivermectin group in the inevitable Table 1, though it’s hard to tell. One interesting possible confounder (not mentioned, but I’m imagining it) is that demented patients probably couldn’t consent to ivermectin and ended up in the control group. This is another case of “I’m not going to trust anything that isn’t an RCT”. Merino et al: Another (sigh) non-RCT. Mexico City tried a public health program where if you called a hotline and said you had COVID, they sent you an emergency kit with various useful supplies. One of those supplies was ivermectin tablets. 18,074 people got the kit (and presumably some appreciable fraction took the ivermectin, though there’s no way to prove that). Their control group is people from before they started giving out the kits, people from after they stopped giving out the kits, and people who didn’t want the kits. There are differences in who got COVID early in the epidemic vs. later, and in people who did opt for medical kits vs. didn’t. To correct these, the researchers tried to adjust for confounders, something which - as I keep trying to hammer home again and again - never works. They found that using the kit led to a 75% or so reduction in hospitalization, though they were unable to separate out the ivermectin from the other things in the kit (paracetamol and aspirin), or from the placebo effect of having a kit and feeling like you had already gotten some treatment (if I understand right, the decision to go to the hospital was left entirely to the patient). I think this study is a moderate point in favor of giving people kits in order to prevent hospital overcrowding, but I’m not willing to accept that it tells us much about ivermectin in particular. Faisal et al: This one was published in The Professional Medical Journal (mispelled as “Profesional Medical Journal” in its URL), so you know it’s going to be good! It describes itself as “a cross-sectional study”, but later says it “randomized patients into two groups”, which would make it an RCT - I think they might just be using the term “cross-sectional” different from the standard American usage. A hospital in Pakistan got 50 patients on ivermectin + azithromycin, and another 50 on azithromycin alone. Primary outcome was not mentioned, and the data were presented confusingly, but a typical result is that only 4% of the ivermectin group had symptoms lasting more than 10 days, whereas 16% of the control group did, p < 0.01. They do a really weird thing where they compare how long it took symptoms to resolve between IVM and control groups within each bin. That is, if I’m understanding correctly, they ask “of the people who took between 3-5 days for symptoms to resolve, did they resolve faster for IVM or control?”. This is an utterly bizarre analysis to perform, although it doesn’t affect the fact that their other results still seem to favor ivermectin. Maybe I’m confused about what’s going on here. I’ve mostly been letting people off easy on no placebo, but I as far as I can tell (not very far) this paper seems to be going off whether patients reported continuing to have symptoms to the hospital doing the study, and I think that is potentially susceptible to placebo effects. Additionally, there’s no preregistration, and even though they talk a lot about doing PCR tests they don’t present the results. This is by no means the worst study here but I still think it’s pretty low quality and I don’t trust it. Aref et al: This one is published in the International Journal Of Nanomedicine, even though I’m pretty sure that isn’t a real thing. In this case the “nanomedicine” is a new nasal spray version of ivermectin which is so confusing I cannot for the life of me figure out what dose they are giving these patients. This Egyptian study gives 57 patients intranasal ivermectin plus hydroxychloroquine, azithromycin, oseltamavir, and some vitamins; another 57 patients get all that stuff except the ivermectin. Primary outcome is not stated, but they look at various symptoms, all of which look better in the ivermectin group: 95% of ivermectin patients got negative PCRs at some time point, compared to 75% of controls, p = 0.004. I am pretty suspicious of this study, not least because it comes from Egypt which has an awful reputation for fake studies, and it returns extreme results that I wouldn’t expect even if ivermectin was actually a wonder drug. But I cannot find any particular thing wrong with it, nor did anyone else I looked at, so I will grudgingly let it stand. Krolewiecki et al: Another Argentine study. This one is a real RCT. 30 patients received ivermectin, 15 were the control group (no placebo, again). Primary outcome was difference in viral load on day 5. The trend favored ivermectin but it was not statistically significant, although they were able to make it statistically significant if they looked at a subset of higher-IVM-plasma-concentration patients. They did not find any difference in clinical outcomes. A pro-ivermectin person could point out that in the subgroup with the highest ivermectin concentrations, the drug seemed to work. A skeptic could point out that this is exactly the kind of subgroup slicing that you are not supposed to do without pre-registering it, which I don’t think this team did. I agree with the skeptic. Vallejos et al: Another Argentine study. It’s big (250 people in each arm). It’s an RCT. It tries to define a primary outcome (“Primary outcome: the trial ended when the last patient who was included achieved the end of study visit”), but that’s not what “primary outcome” means, and they don’t offer an alternative. Other outcomes: no difference in PCR on days 3 or 12. Hospitalization is nonsignificantly better in the ivermectin group (14 vs. 21, p = 0.2), but death is nonsigificantly better in the placebo group (3 vs. 4, p = 0.7). This isn’t even the kind of nonsignificant that might contribute to an exciting meta-analysis later. This is just a pure null result. I cannot find any problem with this study, and neither can anyone else I checked. This is the biggest RCT we’ve seen so far, so we should take it seriously. TOGETHER Trial: Speaking of big RCTs… This one hasn’t been published yet. There’s a video of a talk about it, but I am not going to watch it, because it is a video, so I am getting information secondhand from eg here. Apparently, it compares 677 people (!) randomized to ivermectin to 678 people randomized to placebo. 86 ivermectin patients ended up in the hospital compared to 95 placebo patients, p-value not significant. This was a really big professional trial done by bigshot researchers from a major Canadian university, and the medical establishment is taking it much more seriously than any of these others. When it comes out, it will probably get published in a top journal. When discussing Lopez-Medina, I wrote: When people say things like “sure, a lot of small studies show good results for ivermectin, but the bigger and more professional trials don’t”, this is one of the two big professional trials they’re talking about. This is the other one. Not coincidentally, it’s also the other trial that ivmmeta.com has a warning letter underneath telling you to disregard. Their main concern is that instead of truly randomizing patients to ivermectin vs. placebo, they did a time-dependent randomization that meant during some weeks more patients were getting one or the other. This is a problem because the trial takes place in Brazil, where different variants were more common at different times. Here’s their image: On the one hand, I have immense contempt for ivmmeta for letting all those other awful studies pass and then pulling out all the stops to try to nitpick this one. I have no idea if their proposed randomization failure really happened. And no doubt the reason they’re even able to investigate this is that this study is really careful and transparent - most of them don’t tell you anything about their randomization method. I would be shocked if other studies don’t have all these problems and worse. On the other hand, the point isn’t to be fair, it’s to be right. And this is a potential confounder. Not a huge one. But a potential one. I guess all we can do is try to bound the damage. Even if the confounding is 100% real and bad, there’s no way to make this study consistent with the crazy super-pro-ivermectin results of studies like Espitia-Hernandez and Aref. And even if we deny any confounding, we see the same slight pro-ivermectin trend - 86 hospitalizations vs. 95 - that we’ve seen in so many other studies. Nothing is going to make me believe that this isn’t in the top 33% of studies we’ve been looking at, so let’s add it as grist for the meta-analysis (though maybe not quite as much grist as its vast size indicates) and move on, angrily. Buonfrate et al: An Italian RCT. Patients were randomized into low-dose ivermectin (32), placebo (29), or high-dose ivermectin (32). Primary outcome was viral load on day 7. There was no significant difference (average of 2 in ivermectin groups, 2.2 in placebo group). They admit that they failed to reach the planned sample size, but did a calculation to show that even if they had, the trial could not have returned a positive result. Clinically, an average of 2 patients were hospitalized in each of the ivermectin arms, compared to 0 in the placebo arm - which bucks our previously-very-constant pro-ivermectin trend. Mayer et al: Not an RCT. Patients in an Argentine province were offered the opportunity to try ivermectin; 3266 said yes and become the experimental group, 17966 said no and became the control group. There were many obvious differences between the groups, but they all seemed to handicap ivermectin. There was a nonsignificant trend toward less hospitalization and significantly less mortality (1.5% vs. 2.1%, p = 0.03). While looking into this study, I learned the term “immortal time bias”. This means a period in between selection for the study and the beginning of study recording where patient outcomes are not counted. I think the problem here is that if you signed up for the system on Day X, and if you got sick before they could give you ivermectin, you were in the control group. See this Twitter thread, I have not confirmed everything he says. This only hardens my resolve to stay away from non-RCTs. Borody et al: Our last paper! …is it a paper? I can’t find it published anywhere. It mostly seems to be on news sites. Doesn’t look peer-reviewed. And it starts with “Note that views expressed in this opinion article are the writer’s personal views”. Whatever. 600 Australians were treated with ivermectin, doxycycline, and zinc. The article compares this to an “equivalent control group” made of “contemporary infected subjects in Australia obtained from published Covid Tracking Data”; this is not how you control group, @#!% you. Then it gets excited about the fact that most patients had better symptoms at the end of the ten-day study period than the beginning (untreated COVID resolves in about ten days). Why are these people wasting my time with this? Let’s move on. The Analysis If we remove all fraudulent and methodologically unsound studies from the table above, we end up with this: Gideon Meyerowitz-Katz, who investigated many of the studies above for fraud, tried a similar exercise. I learned about his halfway through, couldn’t help seeing it briefly, but tried to avoid remembering it or using it when generating mine (also, I did take the result of his fraud investigations into account), so they should be considered not quite independent efforts. His looks like this: He nixed Chowdhury, Babaloba, Ghauri, Faisal, and Aref, but kept Szenta Fonseca, Biber (?), and Mayer. There was correlation of 0.45, which I guess is okay. I asked him about his decision-making, and he listed a combination of serious statistical errors and small red flags adding up. I was pretty uncomfortable with most of these studies myself, so I will err on the side of severity, and remove all studies that either I or Meyerowitz-Katz disliked. We end up with the following short list: We’ve gone from 29 studies to 11, getting rid of 18 along the way. For the record, we eliminated 2/19 for fraud, 1/19 for severe preregistration violations, 10 for methodological problems, and 6 because Meyerowitz-Katz was suspicious of them. …but honestly this table still looks pretty good for ivermectin, doesn’t it? Still lots of big green boxes. Meyerowitz-Katz accuses ivmmeta of cherry-picking what statistic to use for their forest plot. That is, if a study measures ten outcomes, they sometimes take the most pro-ivermectin outcome. Ivmmeta.com counters that they used a consistent and reasonable (if complicated) process for choosing their outcome of focus, that being: If studies report multiple kinds of effects then the most serious outcome is used in calculations for that study. For example, if effects for mortality and cases are both reported, the effect for mortality is used, this may be different to the effect that a study focused on. If symptomatic results are reported at multiple times, we used the latest time, for example if mortality results are provided at 14 days and 28 days, the results at 28 days are used. Mortality alone is preferred over combined outcomes. Outcomes with zero events in both arms were not used (the next most serious outcome is used — no studies were excluded). For example, in low-risk populations with no mortality, a reduction in mortality with treatment is not possible, however a reduction in hospitalization, for example, is still valuable. Clinical outcome is considered more important than PCR testing status. When basically all patients recover in both treatment and control groups, preference for viral clearance and recovery is given to results mid-recovery where available (after most or all patients have recovered there is no room for an effective treatment to do better). If only individual symptom data is available, the most serious symptom has priority, for example difficulty breathing or low SpO2 is more important than cough. I’m having trouble judging this, partly because Meyerowitz-Katz says ivmmeta has corrected some earlier mistakes, and partly because there really is some reasonable debate over how to judge studies with lots of complicated endpoints. By this point I had completely forgotten what ivmmeta did, so I independently coded all 11 remaining studies following something in between my best understanding of their procedure and what I considered common sense. The only exception was that when the most severe outcome was measured in something other than patients (ie average number of virus copies per patient), I defaulted to one that was measured in patients instead, to keep everything with the same denominator. My results mostly matched ivmmeta’s, with one or two exceptions that I think are within the scope of argument or related to my minor deviations from their protocol. Placebo vs. ivermectin groups sometimes differed in size, which I’ve adjusted for and rounded off. Probably I’m forgetting some reason I can’t just do simple summary statistics to this, but whatever. It is p = 0.15, not significant. This is maybe unfair, because there aren’t a lot of deaths in the sample, so by focusing on death rather than more common outcomes we’re pointlessly throwing away sample size. What happens if I unprincipledly pick whatever I think the most reasonable outcome to use from each study is? I’ve chosen “most reasonable” as a balance between “is the most severe” and “has a lot of data points”: Now it’s p = 0.04, seemingly significant, but I had to make some unprincipled decisions to get there. I don’t think I specifically replaced negative findings with positive ones, but I can’t prove that even to myself, let alone to you. [UPDATE 5/31/22: A reader writes in to tell me that the t-test I used above is overly simplistic. A Dersimonian-Laird test is more appropriate for meta-analysis, and would have given 0.03 and 0.005 on the first and second analysis, where I got 0.15 and 0.04. This significantly strengthens the apparent benefit of ivermectin from ‘debatable’ to ‘clear’. I discuss some reasons below why I am not convinced by this apparent benefit.] (how come I’m finding a bunch of things on the edge of significance, but the original ivmmeta site found a lot of extremely significant things? Because they combined ratios, such that “one death in placebo, zero in ivermectin” looked like a nigh-infinite benefit for ivermectin, whereas I’m combining raw numbers. Possibly my way is statistically illegitimate for some reason, but I’m just trying to get a rough estimate of how convinced to be) So we are stuck somewhere between “nonsignificant trend in favor” and “maybe-significant trend in favor, after throwing out some best practices”. This is normally where I would compare my results to those of other meta-analyses made by real professionals. But when I look at them, they all include studies later found to be fake, like Elgazzar, and unsurprisingly come up with wildly positive conclusions. There are about six in this category. One of them later revised their results to exclude Elgazzar and still found strong efficacy for ivermectin, but they still included Niaee and some other dubious studies. The only meta-analysis that doesn’t make these mistakes is Popp (a Cochrane review), which is from before Elgazzar was found to be fraudulent, but coincidentally excludes it for other reasons. It also excludes a lot of good studies like Mahmud and Ravakirti because they give patients other things like HCQ and azithromycin - I chose to include them, because I don’t think they either work or have especially bad side effects, so they’re basically placebo - but Cochrane is always harsh like this. They end up with a point estimate where ivermectin cuts mortality by 40% - but say the confidence intervals are too wide to draw any conclusion. I think this basically agrees with my analyses above - the trends really are in ivermectin’s favor, but once you eliminate all the questionable studies there are too few studies left to have enough statistical power to reach significance. Except that everyone is still focusing on deaths and hospitalizations just because they’re flashy. Mahmud et al, which everyone agrees is a great study, found that ivermectin decreased days until clinical recovery, p = 0.003? So what do you do? This is one of the toughest questions in medicine. It comes up again and again. You have some drug. You read some studies. Again and again, more people are surviving (or avoiding complications) when they get the drug. It’s a pattern strong enough to common-sensically notice. But there isn’t an undeniable, unbreachable fortress of evidence. The drug is really safe and doesn’t have a lot of side effects. So do you give it to your patients? Do you take it yourself? Here this question is especially tough, because, uh, if you say anything in favor of ivermectin you will be cast out of civilization and thrown into the circle of social hell reserved for Klan members and 1/6 insurrectionists. All the health officials in the world will shout “horse dewormer!” at you and compare you to Josef Mengele. But good doctors aren’t supposed to care about such things. Your only goal is to save your patient. Nothing else matters. I am telling you that Mahmud et al is a good study and it got p = 0.003 in favor of ivermectin. You can take the blue pill, and stay a decent respectable member of society. Or you can take the horse dewormer pill, and see where you end up. In a second, I’ll tell you my answer. But you won’t always have me to answer questions like this, and it might be morally edifying to observe your thought process in situations like this. So take a second, and meet me on the other side of the next section heading. … … … … … The Synthesis Hopefully you learned something interesting about yourself there. But my answer is: worms! As several doctors and researchers have pointed out (h/t especially Avi Bitterman and David Boulware), the most impressive studies come from places that are teeming with worms. Mahmud from Bangladesh, Ravakirti from East India, Lopez-Medina from Colombia, etc. Here’s the prevalence of roundworm infections by country (source). But alongside roundworms, there are threadworms, hookworms, blood flukes, liver flukes, nematodes, trematodes, all sorts of worms. Add them all up and somewhere between half and a quarter of people in the developing world have at least one parasitic worm in their body. Being full of worms may impact your ability to fight coronavirus. Gluchowska et al write: Helminth [ie worm] infections are among the most common infectious diseases. Bradbury et al. highlight the possible negative interactions between helminth infection and COVID-19 severity in helminth-endemic regions and note that alterations in the gut microbiome associated with helminth infection appear to have systemic immunomodulatory effects. It has also been proposed that helminth co-infection may increase the morbidity and mortality of COVID-19, because the immune system cannot efficiently respond to the virus; in addition, vaccines will be less effective for these patients, but treatment and prevention of helminth infections might reduce the negative effect of COVID-19. During millennia of parasite-host coevolution helminths evolved mechanisms suppressing the host immune responses, which may mitigate vaccine efficacy and increase severity of other infectious diseases. Treatment of worm infections might reduce the negative effect of COVID-19! And ivermectin is a deworming drug! You can see where this is going… The most relevant species of worm here is the roundworm Strongyloides stercoralis. Among the commonest treatments for COVID-19 is corticosteroids, a type of immunosuppresant drug. The types of immune responses it suppresses do more harm than good in coronavirus, so turning them off limits collateral damage and makes patients better on net. But these are also the types of immune responses that control Strongyloides. If you turn them off even very briefly, the worms multiply out of control, you get what’s called “Strongyloides hyperinfection”, and pretty often you die. According to the WHO: The current COVID-19 pandemic serves to highlight the risk of using systemic corticosteroids and, to a lesser extent, other immunosuppressive therapy, in populations with significant risk of underlying strongyloidiasis. Cases of strongyloidiasis hyperinfection in the setting of corticosteroid use as COVID-19 therapy have been described and draw attention to the necessity of addressing the risk of iatrogenic strongyloidiasis hyperinfection syndrome in infected individuals prior to corticosteroid administration. Although this has gained importance in the midst of a pandemic where corticosteroids are one of few therapies shown to improve mortality, its relevance is much broader given that corticosteroids and other immunosuppressive therapies have become increasingly common in treatment of chronic diseases (e.g. asthma or certain rheumatologic conditions). So you need to “address the risk” of strongyloides infection during COVID treatment in roundworm-endemic areas. And how might you address this, WHO? Treatment of chronic strongyloidiasis with ivermectin 200 µg/kg per day orally x 1-2 days is considered safe with potential contraindications including possible Loa loa infection (endemic in West and Central Africa), pregnancy, and weight <15kg. Given ivermectin’s safety profile, the United States has utilized presumptive treatment with ivermectin for strongyloidiasis in refugees resettling from endemic areas, and both Canada and the European Centre for Disease Prevention and Control have issued guidance on presumptive treatment to avoid hyperinfection in at risk populations. Screening and treatment, or where not available, addition of ivermectin to mass drug administration programs should be studied and considered. This is serious and common enough that, if you’re not going to screen for it, it might be worth “add[ing] ivermectin to mass drug administration programs” in affected areas! Dr. Avi Bitterman carries the hypothesis to the finish line: First two images are with all relevant studies; second two are a sensitivity analysis that removes some of the most dubious. The good ivermectin trials in areas with low Strongyloides prevalence, like Vallejos in Argentina, are mostly negative. The good ivermectin trials in areas with high Strongyloides prevalence, like Mahmud in Bangladesh, are mostly positive. Worms can’t explain the viral positivity outcomes (ie PCR), but Dr. Bitterman suggests that once you remove low quality trials and worm-related results, the rest looks like simple publication bias: This is still just a possibility. Maybe I’m over-focusing too hard on a couple positive results and this will all turn out to be nothing. Or who knows, maybe ivermectin does work against COVID a little - although it would have to be very little, fading to not at all in temperate worm-free countries. But this theory feels right to me. It feels right to me because it’s the most troll-ish possible solution. Everybody was wrong! The people who called it a miracle drug against COVID were wrong. The people who dismissed all the studies because they F@#king Love Science were wrong. Ivmmeta.com was wrong. Gideon Meyerowitz-Katz was…well, he was right, actually, I got the worm-related meta-analysis graphic above from his Twitter timeline. Still, an excellent troll. Also, the best part is that I ignorantly asked, in my description of Mahmud et al above: And it was! It was a fluke! A literal, physical, fluke! For my whole life, God has been placing terrible puns in my path to irritate me, and this would be the worst one ever! So it has to be true! The Scientific Takeaway About ten years ago, when the replication crisis started, we learned a certain set of tools for examining studies. Check for selection bias. Distrust “adjusting for confounders”. Check for p-hacking and forking paths. Make teams preregister their analyses. Do forest plots to find publication bias. Stop accepting p-values of 0.049. Wait for replications. Trust reviews and meta-analyses, instead of individual small studies. These were good tools. Having them was infinitely better than not having them. But even in 2014, I was writing about how many bad studies seemed to slip through the cracks even when we pushed this toolbox to its limits. We needed new tools. I think the methods that Meyerowitz-Katz, Sheldrake, Heathers, Brown, Lawrence and others brought to the limelight this year are some of the new tools we were waiting for. Part of this new toolset is to check for fraud. About 10 - 15% of the seemingly-good studies on ivermectin ended up extremely suspicious for fraud. Elgazzar, Carvallo, Niaee, Cadegiani, Samaha. There are ways to check for this even when you don’t have the raw data. Like: The Carlisle-Stouffer-Fisher method: Check some large group of comparisons, usually the Table 1 of an RCT where they compare the demographic characteristics of the control and experimental groups, for reasonable p-values. Real data will have p-values all over the map; one in every ten comparisons will have a p-value of 0.1 or less. Fakers seem bad at this and usually give everything a nice safe p-value like 0.8 or 0.9.
Inline links: Lopez-Medina et al:, Roy et al:, Chahla et al:, Mourya et al:, Loue et al:, Table 1, Merino et al:, never works, Faisal et al:, Aref et al:, https://substackcdn.com/image/fetch/$s_!-FoK!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2Ff6de79b6-091b-4c13-b7be-715c9bb194a7_986x810.jpeg, Krolewiecki et al:, Vallejos et al:, TOGETHER Trial:, here, https://substackcdn.com/image/fetch/$s_!7X0m!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F1f65fd44-58b9-4489-a934-02a5a7330499_706x768.png, Buonfrate et al:, Mayer et al:, immortal time bias, this Twitter thread, Borody et al:, https://substackcdn.com/image/fetch/$s_!Wpjs!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F2d8a451b-b1fc-44e5-ae67-b1506e491762_914x657.png, https://substackcdn.com/image/fetch/$s_!DOjA!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F17d5827a-38da-4a99-beb3-c3018df5c633_920x604.png, https://substackcdn.com/image/fetch/$s_!GX1n!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2Fc692fec8-a450-4579-b337-c72bec060970_912x298.png, https://substackcdn.com/image/fetch/$s_!YcH4!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2Ff36db98e-e653-44da-906c-20312b1689a3_468x205.png, https://substackcdn.com/image/fetch/$s_!jbcL!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2Fd189a844-daf2-4199-bb2e-830d4fc64415_468x206.png, later revised their results to exclude Elgazzar, Popp, https://substackcdn.com/image/fetch/$s_!2B6r!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F505c5ac4-3fe8-47a4-8505-dab80601b44d_416x198.png, Avi Bitterman, David Boulware, https://substackcdn.com/image/fetch/$s_!JWWh!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2Fac9e4f34-f9cc-40f2-9d83-da4e7178fad7_772x330.png, source, Gluchowska et al, the WHO, carries, https://substackcdn.com/image/fetch/$s_!xExE!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F5da21781-249c-4e59-b616-9f23d83cc044_2048x1184.jpeg, https://substackcdn.com/image/fetch/$s_!4SMr!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2Fdcd6e4b2-37f7-4602-93d5-2581c3b27a60_700x432.png, https://substackcdn.com/image/fetch/$s_!-6n2!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F7fd6e8f4-093e-4e02-bce7-363615146c9c_2228x1346.jpeg, https://substackcdn.com/image/fetch/$s_!CPZs!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2Fb0425847-198a-4bd3-a63b-149f15d147ba_700x432.png, https://substackcdn.com/image/fetch/$s_!H3rK!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F9972491b-25b0-4c06-8aca-86fce102ae63_666x147.png, even in 2014, The Carlisle-Stouffer-Fisher method
Source. Real data would follow something like a bell curve. This is going to require a social norm of always sharing data. Even better, journals should require the raw data before they publish anything, and should make it available on their website. People are going to fight hard against this, partly because it’s annoying and partly because of (imho exaggerated) patient privacy related concerns. Somebody’s going to try make some kind of gated thing where you have to prove you have a PhD and a “legitimate cause” before you can access the data, and that person should be fought tooth and nail (some of the “data detectives” who figured out the ivermectin study didn’t have advanced degrees). I want a world where “I did a study, but I can’t show you the data” should be taken as seriously as “I determined P = NP, but I can’t show you the proof.” The second reason I think this, aside from checking for fraud, is checking for mistakes. I have no proof this was involved in ivermectin in particular. But I’ve been surprised how often it comes up when I talk to scientists. Someone in their field got a shocking result, everyone looked over the study really hard and couldn’t find any methodological problems, there’s no evidence of fraud, so do you accept it? A lot of times instead I hear people say “I assume they made a coding error”. I believe them, because I have made a bunch of stupid errors. Sometimes you make the errors for me - an early draft of this post of mine stated that there was an strong positive effect of assortative mating on autism, but when I double-checked it was entirely due to some idiot who filled out the survey and claimed to have 99999 autistic children. In this very essay, I almost said that a set of ivermectin studies showed a positive result because I was reading the number for whether two lists were correlated rather than whether a paired-samples t-test on the lists was significant. I think lots of studies make these kinds of errors. But even if it’s only 1%, these will make up much more than 1% of published studies, and much more than 1% of important ground-breaking published studies, because correct studies can only prove true things, but false studies can prove arbitrarily interesting hypotheses (did you know there was an increase in the suicide rate on days that Donald Trump tweeted?!?) and those are the ones that will get published and become famous. So if the lesson of the original replication crisis was “read the methodology” and “read the preregistration document”, this year’s lesson is “read the raw data”. Which is a bit more of an ask. Especially since most studies don’t make it available. The Sociological Takeaway I’ve been thinking about this one a lot too. Ivermectin supporters were really wrong. I enjoy the idea of a cosmic joke where ivermectin sort of works in some senses in some areas. But the things people were claiming - that ivermectin has a 100% success rate, that you don’t need to take the vaccine because you can just take ivermectin instead, etc - have been untenable not just since the big negative trials came out this summer, but even by the standards of the early positive trials. Mahmud et al was big and positive and exciting, but it showed that ivermectin patients recovered in about 7 days on average instead of 9. I think the conventional wisdom - that the most extreme ivermectin supporters were mostly gullible rubes who were bamboozled by pseudoscience - was basically accurate. Mainstream medicine has reacted with slogans like “believe Science”. I don’t know if those kinds of slogans ever help, but they’re especially unhelpful here. A quick look at ivermectin supporters shows their problem is they believed Science too much. @jonno_bosch I work in hospitality so I need things to return to normal ASAP. I am using Ivermectin as a prophylactic. Hugely influenced by Carvallo trail and Chala trail which showed huge protection","username":"Bannisterious","name":"Andrew Bannister","profile_image_url":"","date":"Fri Feb 12 16:21:14 +0000 2021","photos":[],"quoted_tweet":{},"reply_count":0,"retweet_count":0,"like_count":0,"impression_count":0,"expanded_url":{},"video_url":null,"belowTheFold":true}" data-component-name="Twitter2ToDOM"> @mtskullcrusher @HereComeTheJud @therealjosexy @joeycadre @PeegeRiley @dcwickedestcity @blaireerskine Read Raad. Or Mahmud. Or ICON study from Florida. Or Mexico City hospitalizations study. Or Niaee. Or...\n\nOr just type \"ivermectin covid\" in Google Scholar and read.","username":"fatlas6","name":"fatlas","profile_image_url":"","date":"Thu Sep 02 21:34:59 +0000 2021","photos":[],"quoted_tweet":{},"reply_count":0,"retweet_count":0,"like_count":1,"impression_count":0,"expanded_url":{},"video_url":null,"belowTheFold":true}" data-component-name="Twitter2ToDOM"> They have a very reasonable-sounding belief, which is that if dozens of studies all say a drug works really well, then it probably works really well. When they see dozens of studies saying a drug works really well, and the elites saying “no don’t take it!”, their extremely natural conclusion is that it works really well but the elites are covering it up. Sometimes these people even have a specific theory for why elites are covering up ivermectin, like that pharma companies want you to use more expensive patented drugs instead. This theory is extremely plausible. Pharma companies are always trying to convince people to use expensive patented drugs instead of equally good generic alternatives. Ivermectin believers probably heard about this from the many, many good articles by responsible news outlets, discussing the many, many times pharma companies have tried to trick people into using more expensive patented medications. Like this ACSH article about Nexium. Or my article on esketamine. Given that dozens of studies said a drug worked, and elites continued to deny it worked, and there are well-known times where elites lie about drugs in order to make money, it was an incredibly reasonable inference that this was one of those times. If you have a lot of experience with pharma, you know who lies and who doesn’t, and you know what lies they’re willing to tell and which ones they shrink back from. As far as I know, no reputable scientist has ever come out and said ‘esketamine definitely works better than regular ketamine’. The regulatory system just heavily implied it. I claim that with ivermectin, even the people who don’t usually lie were saying it was ineffective, and they were saying it more directly and decisively than liars usually do. But most people can’t translate Pharma → English fluently enough to know where the space of “things people routinely lie about and nobody worries about it too much” ends. So they incredibly reasonably assume anything could be a lie. And if you don’t know which statements about pharmaceuticals are lies, “the one that has dozens of studies contradicting it” is a pretty good heuristic! If you tell these people to “believe Science”, you will just worsen the problem where they trust dozens of scientific studies done by scientists using the scientific method over the pronouncements of the CDC or whoever. So “believe experts”? That would have been better advice in this case. But the experts have beclowned themselves again and again throughout this pandemic, from the first stirrings of “anyone who worries about coronavirus reaching the US is dog-whistling anti-Chinese racism”, to the Surgeon-General tweeting “Don’t wear a face mask”, to government campaigns focusing entirely on hand-washing (HEPA filters? What are those?) Not only would a recommendation to trust experts be misleading, I don’t even think you could make it work. People would notice how often the experts were wrong, and your public awareness campaign would come to naught. But also: one of the data detectives who exposed some fraudulent ivermectin papers was a medical student, which puts him somewhere between pond scum and hookworms on the Medical Establishment Totem Pole. Some of the people whose studies he helped sink were distinguished Professors of Medicine and heads of Health Institutes. If anyone interprets “trust experts” as “mere medical students must not publicly challenge heads of Health Institutes”, then we’ve accidentally thrown the fundamental principle of science out with the bathwater. But Pierre Kory, spiritual leader of the Ivermectin Jihad, is a distinguished critical care doctor. What heuristic tells us “Medical students should be allowed to publicly challenge heads of Health Institutes” but not “Distinguished critical care doctors should be allowed to publicly challenge the CDC”? Then what about “believe statisticians”? I’ve never heard anyone propose this before, but re-centering the mystique of scientific-expertise in study-analyzers and study-aggregators rather than object-level scientists is…one way you could go, I guess. Statisticians admittedly sort of failed us here: the first several meta-analyses said ivermectin worked. But the statistical process - the idea that studies are raw materials, but it takes skill to turn them into the finished good of scientific knowledge - sort of comes out looking good. If we need to summarize our takeaway in a slogan of exactly two words, one of which is “trust”, you could do worse than this one. (am I secretly suggesting that we make rationality higher status? Maybe, although rationalists did no better here during the early phase of “looks promising so far” than anyone else, and it was researchers digging into the nitty-gritty of the data who really solved this.) Or maybe this is the wrong level on which to think about this. Maybe there isn’t and can’t be a simple heuristic you can teach everyone in school or via a PR campaign which will lead to them having making good health decisions in an adversarial information environment, without having any negative effects anywhere else. But you also don’t want people to make bad health decisions. So what do you do? The Political Takeaway All of this is complicated by the impression many people (including me) have, that ivermectin boosterism and vaccine denialism are closely linked. The ivermectin evidence is complicated. There’s room for doubt. I can maybe see room for doubt on some marginal vaccine-related issues like how seriously to take the occasional reports of myocarditis in teens. But the basic issue - that the vaccine works really well and is incredibly safe for adults - seems beyond question. Yet people keep questioning it. I think it’s important to address ivermectin support on its own terms - as a potentially plausible scientific theory in a debris field of confusing evidence, which should be debated to the usual standards of scientific debate. I’ve tried to do that above. But this picture wouldn’t be complete without acknowledging the overlap with vaccine denial - a segment of people who are completely crazy and wrong and who happen to have fixated on this mildly interesting question as opposed to some other one with even less evidence. I’ve been trying to figure out a model where ivermectin support and vaccine denialism both make visceral sense to me, and here’s what I’ve got: Imagine that in 2025, an alien invasion fleet reaches Earth. But it got hit by a supernova on the way, the spaceships are partly disabled, and they’re only able to conquer some out-of-the-way place - let’s say Australia. There’s a few cycles of conflict and cease-fire, a few cities get nuked, and finally we settle into an uneasy peace. Over the next few years, humanity grudgingly admits the invaders into the world community. They get a seat in the United Nations. We sort of cooperate with them on projects that are important to both sides, like stopping climate change. We still hate them, but only at the level of ordinary international rivalries, like USA/USSR. In 2035, the aliens announce that a quantum memetic plague from the Andromeda Sector has reached Earth. Billions of people will die unless we let them put an immunity-granting cybernetic implant in all humans’ brain. The aliens admit we haven’t always been friends, and honestly they would still like to conquer us someday. But this plague is an ancient enemy of all sentient beings, they dealt with it on their homeworld eons ago, and they want to help us out here. Humans apparently don’t have the ability to detect quantum memetic plagues, but mortality rates for over-65s do seem weirdly high this year, something like 10x worse than a normal flu season. Do you let the aliens put an implant in your brain, or not? If it helps, the aliens look like this. Surely anyone with a brain that size must know what they’re talking about, right? (source) Fine, you don’t have to decide immediately. The brain implants aren’t even ready yet. Some human scientists suggest wearing face masks in the interim. The aliens say no, that will never work, that’s not how you deal with quantum memetic plagues, if you do anything other than wait for the brain implants you’re anti-science idiots who are wasting precious time and will kill millions of people. Human nations try face masks anyway…and they clearly and conspicuously work. The aliens say whatever, we’re still the advanced spacefaring civilization here, maybe it works for humans but that’s not the point, the point is you’ve got to let us put implants in your brains. Some human scientists suggest reopening vital services. The aliens say no, millions will die, this is “mass human sacrifice”, humans apparently must care nothing about their families’ lives. The humans try reopening anyway, and…it goes kind of okay? Maybe the death rate goes up 10% to 20% or so, hard to say? The aliens say whatever, maybe their calculations were off by a few orders of magnitude, the point is, you have to let us put implants in your brain or you’ll all die. Then some human scientists suggest vaccinating against the plague. The aliens say this is idiotic, vaccines originally come from cowpox, even the word “vaccine” comes from Latin vaccus meaning “cow”, are you saying you want cow medicine instead of actual brain implants which alien Science has proven will work? They make lots of cartoons displaying humans who want vaccines as having cow heads, or rolling around in cow poop. Meanwhile, the first few dozen studies show vaccines work great. Many top human leaders, including war heroes from the struggle against the aliens, get vaccines and are seen going out in public, looking healthy and happy. The aliens say that human science is hopelessly flawed because of complicated statistical concepts that inferior life forms like us don’t even have words for. You need to ignore all the studies and meta-analyses showing that vaccines definitely work, and let the aliens give you brain implants instead. So do you let the aliens put an implant in your brain, or not? Obviously you think long and hard before doing this. And obviously this is an extended metaphor for vaccine denialism. So what’s the difference between the metaphor (where you’re presumably anti-implant) and the real world (where you’re presumably pro-vaccine?) For me, it’s a combination of: The aliens are hostile, so I don’t trust them no matter how smart they are
Inline links: Source, this post, this ACSH article about Nexium, my article on esketamine, https://substackcdn.com/image/fetch/$s_!1UIV!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F598d7d6c-de95-4b94-b13a-3c8a452b0409.jp2, source
pharmaceutical companies1 mentions across 1 issues

pharmaceutical companies is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between March 03, 2021 and March 03, 2021. The archive places it in contexts such as "anticompetitive effects of common ownership in pharmaceutical companies". It most often appears alongside 9-11, Argentina, Austin Allred.

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March 03, 2021
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March 03, 2021
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Links For March
March 03, 2021 · Original source
14: Related: anticompetitive effects of common ownership in pharmaceutical companies (paywalled). If a big pharma company shares lots of stockholders (eg Blackrock) with a generic company, it will put up less of a fuss when the generic company tries to copy their drug. This particular example is good because people get cheap medication more easily; for reasons why the overall trend might be worrying, see The Problem Of Twelve.
Inline links: anticompetitive effects of common ownership in pharmaceutical companies, The Problem Of Twelve
pharmacokinetic modeling1 mentions across 1 issues

pharmacokinetic modeling is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between December 28, 2021 and December 28, 2021. The archive places it in contexts such as "to help with pharmacokinetic modeling of a possible treatment". It most often appears alongside 1DaySooner, 2016 Washington carbon tax ballot initiative, @GoodSciProject.

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December 28, 2021
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December 28, 2021
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ACX Grants Results
December 28, 2021 · Original source
Trevor Klee, $20,000, to help with pharmacokinetic modeling of a possible treatment for neurodegenerative and autoimmune diseases in advance of phase 1 trials. You may have already read some of Trevor's excellent essays on pharmacology, and I look forward to reading more about his successes and failures leading his new pharmaceutical startup. He's looking for a technical cofounder/CSO who's interested in drug repurposing, neurodegeneration, or autoimmune diseases. If that sounds like you or someone you know, please reach out through https://highwaypharm.com/
Inline links: Trevor Klee, essays on pharmacology, https://highwaypharm.com/
pharmacology1 mentions across 1 issues

pharmacology is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between December 28, 2021 and December 28, 2021. The archive places it in contexts such as "Trevor's excellent essays on pharmacology". It most often appears alongside 1DaySooner, 2016 Washington carbon tax ballot initiative, @GoodSciProject.

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pharmacology
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ACX Grants Results
December 28, 2021 · Original source
Trevor Klee, $20,000, to help with pharmacokinetic modeling of a possible treatment for neurodegenerative and autoimmune diseases in advance of phase 1 trials. You may have already read some of Trevor's excellent essays on pharmacology, and I look forward to reading more about his successes and failures leading his new pharmaceutical startup. He's looking for a technical cofounder/CSO who's interested in drug repurposing, neurodegeneration, or autoimmune diseases. If that sounds like you or someone you know, please reach out through https://highwaypharm.com/
Inline links: Trevor Klee, essays on pharmacology, https://highwaypharm.com/
pharmakoi1 mentions across 1 issues

pharmakoi is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between November 17, 2023 and November 17, 2023. The archive places it in contexts such as "The pharmakoi of Greece, which Wikipedia describes as “a slave, a cripple, or a criminal". It most often appears alongside Abel, Adam and Eve, America.

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pharmakoi
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Book Review: I See Satan Fall Like Lightning
November 17, 2023 · Original source
But also, various real-world practices. The ostracism in Athens. The scapegoat of Israel. The pharmakoi of Greece, which Wikipedia describes as “a slave, a cripple, or a criminal was chosen and expelled from the community at times of disaster”.
Inline links: Wikipedia describes as
Pharr-style1 mentions across 1 issues

Pharr-style is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between February 03, 2022 and February 03, 2022. The archive places it in contexts such as "commentaries in the Pharr-style popularized by Geoffrey Steadman". It most often appears alongside 538, 55-gal drum, 750k horny men.

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Pharr-style
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1
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February 03, 2022
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February 03, 2022
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ACX Grants ++: The First Half
February 03, 2022 · Original source
#62: Commentaries On Greek And Latin Literature Greek and Latin literature for all! My project is a series of commentaries in the Pharr-style popularized by Geoffrey Steadman (geoffreysteadman.com). I am now working on an edition of book four of Virgil's Georgics. Future projects will include: the Passion of Saints Perpetua and Felicity; Plato's Gorgias; the books of Augustine's Confessions; and the comedies of Terence. For the edition of Virgil's Georgics, I estimate needing $1200 to pay an undergraduate Classics major $15/hour to help me compile vocabulary lists. My purpose for the project is, first, to help my own students have a more satisfying experience in their Greek and Latin courses and, secondly, to encourage anyone who has serious interest, but limited time, to read ancient Greek and Latin literature. Like Steadman, I intend to self-publish my commentaries, selling paperback editions for ≈ $15/copy, while making free PDF versions available on my website (andrew-beer.com).
Phase 1 trials1 mentions across 1 issues

Phase 1 trials is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between February 01, 2023 and February 01, 2023. The archive places it in contexts such as "we do Phase 1 trials on a drug". It most often appears alongside 2006 Ioannidis paper, ACTIV-6, Alexandros.

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Phase 1 trials
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February 01, 2023
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Response To Alexandros Contra Me On Ivermectin
February 01, 2023 · Original source
Third, feeling like all of this analysis has actually gotten somewhere. I started looking into this because I wanted to know why studies so often fail, or return contradictory results. I appreciated the perspective Dr. Bitterman relayed to me on this, which is - come on, this always happens, we do Phase 1 trials on a drug, it looks promising, and then we do Phase 3 trials and it fails, this is how medicine works. He’s right and this is the correct attitude towards drug development.
Phase 3 trials1 mentions across 1 issues

Phase 3 trials is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between February 01, 2023 and February 01, 2023. The archive places it in contexts such as "and then we do Phase 3 trials and it fails". It most often appears alongside 2006 Ioannidis paper, ACTIV-6, Alexandros.

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Phase 3 trials
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February 01, 2023
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February 01, 2023
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Response To Alexandros Contra Me On Ivermectin
February 01, 2023 · Original source
Third, feeling like all of this analysis has actually gotten somewhere. I started looking into this because I wanted to know why studies so often fail, or return contradictory results. I appreciated the perspective Dr. Bitterman relayed to me on this, which is - come on, this always happens, we do Phase 1 trials on a drug, it looks promising, and then we do Phase 3 trials and it fails, this is how medicine works. He’s right and this is the correct attitude towards drug development.
But in other fields - the one that comes to mind now is declining sperm count, which I’m trying to write an article on - there aren’t the equivalent of Phase 3 trials. Just a hodgepodge of smaller or bigger studies, probably about as good as the ones that find ivermectin improves viral clearance, producing a hodgepodge of noisy results. Then some statistician draws a line through the noise and tells us the line is pointing up and that means we should be worried. Should we? What about silexan for anxiety? There are five studies - better than the worst ivermectin studies, but nowhere close to Phase 3 - and they find positive results. Silexan would revolutionize the treatment of anxiety and help avoid medications with much worse side effects. Do I start recommending it as a first line treatment?
Inline links: silexan for anxiety
Phase I Research1 mentions across 1 issues

Phase I Research is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between June 23, 2025 and June 23, 2025. The archive places it in contexts such as "Finalists are Phase I Research". It most often appears alongside ACX Grants, Alpha School, Astralcodexten.

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Phase I Research
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June 23, 2025
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June 23, 2025
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Open Thread 387
June 23, 2025 · Original source
3: Thank you to everyone who voted for finalists in this year’s Nonbook Review Contest. All entries among the top ten best-ranked reviews became automatic finalists, and I also added two more from the 10-25 tier that voters or I especially liked. Honorable mentions were others from the 10-25 tier that I liked a lot. Finalists are Alpha School, Dementia, Islamic Geometric Patterns, Joan of Arc, Mashed Potatoes, Men, Ollantay, Phase I Research, Synaptic Plasticity, The ACX Commentariat, The Internet That Might Have Been, and The Russo-Ukrainian War. Honorable Mentions are at least Bishop's Castle, Bukele, Elon Musk's Algorithm, JFK Conspiracies, Martial Arts, Miniatur Wunderland, School (Review 1 by DK), and Watergate. I may promote some honorables to finalists depending on reader tolerance or unexpected opportunities. I will give you finer-grained score information after the contest ends. First finalist post is planned for this Friday.
phenomenology1 mentions across 1 issues

phenomenology is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between June 03, 2023 and June 03, 2023. The archive places it in contexts such as "the influence of Husserl and phenomenology is clear throughout the book". It most often appears alongside 2023 book review contest, AGI, Alan Turing.

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phenomenology
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June 03, 2023
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June 03, 2023
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Your Book Review: Why Machines Will Never Rule the World
June 03, 2023 · Original source
I set out to find the best book-length argument—one that really engages with the technical issues—against imminent, world-dooming, Skynet-and-Matrix-manifesting artificial intelligence. I arrived at Why Machines Will Never Rule the World by Jobst Landgrebe and Barry Smith, published by Routledge just last year. Landgrebe, an AI and biomedicine entrepreneur, and Smith, an eminent philosopher, are connected by their study of Edmund Husserl, and the influence of Husserl and phenomenology is clear throughout the book. (“Influence of Husserl” is usually a good enough reason to stop reading something.)
Phi1 mentions across 1 issues

Phi is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between November 08, 2022 and November 08, 2022. The archive places it in contexts such as "the golden ratio φ=1.618... is best for anti-resonance". It most often appears alongside Alexander Buhl, ANNs, Bay Area House Party.

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Phi
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November 08, 2022
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November 08, 2022
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Highlights From The Comments On Brain Waves
November 08, 2022 · Original source
Instead of 2.17, the golden ratio φ=1.618... is best for anti-resonance. This is because φ is maximally difficult to rationally approximate.
The golden ratio's continued fraction expansion is all 1's, so in this sense it has the worst rational approximations of any real number. In practice, people tend to care about the asymptotics of this approximation quality, which leads to the notion of https://mathworld.wolfram.com/IrrationalityMeasure.html. More concrete implications between the terms of the continued fraction and the badness of rational approximations in this sense are mentioned at this MathOverflow thread: https://mathoverflow.net/questions/89600/numbers-with-known-irrationality-measures
Inline links: https://mathworld.wolfram.com/IrrationalityMeasure.html, https://mathoverflow.net/questions/89600/numbers-with-known-irrationality-measures
Philadelphia Cook1 mentions across 1 issues

Philadelphia Cook is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between August 08, 2025 and August 08, 2025. The archive places it in contexts such as "Using a multi-step process called the “Philadelphia Cook”"; "real mashing with the Philadelphia Cook". It most often appears alongside Ainu, Altiplano, American cheese.

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Philadelphia Cook
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August 08, 2025
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Your Review: My Father’s Instant Mashed Potatoes
August 08, 2025 · Original source
These shreds resemble the ancestral stock of modern Instant Mashed Potatoes (source) The result was an affront. The potatoes were swimming in their own gluten, released during the granule-making process, which when mixed with imprecise water ratios made for a slop that was somehow both gluey and soupy. Immediately after the war, French’s (now best known for mustard) tried to introduce “instant mashed potatoes” as a consumer product category. America’s veterans were not having it. They didn’t want to be reminded of the awful slurry they’d had on the front. The commercial fortunes of instant mashed potatoes began to turn around a decade later, however, when food scientists in the US and Canada converged on methods for producing dehydrated potato flakes rather than granules. The flakes had substantial advantages. They didn’t get as glutinous when reconstituted. Their geometry made them easier to dry quickly, on the order of minutes or even seconds. Using a multi-step process called the “Philadelphia Cook”, they could lock in a more natural flavor. When prepared on the stove with butter and milk, they were supposed to turn out almost as good as the real thing without any onerous prep work on the part of the consumer. This raises the question, though, of why food scientists kept working on improving instant mashed potatoes a decade after they were no longer required for the war effort. If you’re no longer constrained by having to stick it to the Axis, why not return to Glasse-style maſhed potatoes in all circumstances? This is a pattern that recurs frequently in reading about American foodways of the 20th century: choices and innovations made under extreme duress in the World War II economy didn’t fade away when the duress subsided. Instead they echoed back into American life a few years later, despite the lean conditions that birthed them being replaced by extreme abundance. Why did America start eating like it was on a total war footing again when my parents’ generation was young? There are a lot of overlapping explanations. Here are a few: Industrial inertia: Companies that had spun up to supply a vast army didn’t want to shut down overnight, so they necessarily pivoted to the consumer market. Some of these efforts succeeded at entrenching new consumer categories (fish sticks, canned peaches) while others (hamburgers-in-a-can) did not.
Inline links: source
Pursuit of efficiency: As women entered the workforce en masse in the postwar era, the pool of hours available to be spent on domestic labor like cooking shrank. As much as any dishwasher or washing machine, convenience foods are labor-saving, productivity-enhancing technologies for the home. This last factor is the only one that can explain the continued development of instant mashed potato technology. There were no potato-flaking interests during the war to have inertia; the instant mashed potatoes are not superior to their fresh antecedents; there was no ingrained consumer preference for an instant mashed potato product. It is only the desire to reduce time spent on food prep that could create “better instant mashed potatoes” as a commercially viable R&D space in the 1950s. The other factors contributed to the unique awfulness of my father’s instant mashed potatoes, though. Another WWII technological innovation, the cavity magnetron used in radar installations, led directly to the invention of the home microwave oven which began to proliferate widely in the 1970s. The microwave supercharged all “convenience food” trends, shortening not just prep time but cooking time as well. Uneven heating is hardly a concern when you can speed up your meals by a factor of ten. Meanwhile, the existing postwar status of margarine and skim milk was greatly enhanced by the dietary fat scare of the 1980s and 1990s. These products displaced butter and whole milk as health-conscious consumers sought to eliminate saturated fats from their diets in a doomed effort to stave off the incipient obesity epidemic. My parents, both already primed to accept these imitative products by my grandparents’ wartime preference formation, exclusively purchased margarine and skim milk for the household once they got married. And, pressed for time with two jobs and two kids, they frequently purchased instant mashed potatoes as well. And cooked them in the microwave. What resulted was a second-order simulation of true maſhed potatoes, perverted and made unreal by the consumer echoes of the second world war. Real potatoes were substituted with desiccated flakes, real milk with a thin byproduct, real butter with refined vegetable oil, real mashing with the Philadelphia Cook, a real stovetop flame with microwave excitation. The measuring cup contained a substance gesturing at the notion of “mashed potatoes”, but no aspect of the original remained. Yet because the name was the same, my father still believed he was eating the same dish my grandma made, the same dish his ancestors ate in Ireland, the same dish Glasse wrote about a quarter millennium ago. The appeal to him was undiminished. His body ate the slurry, but his mind still ate the maſhed potatoes of his youth. My World is Built on Lies In researching whether the ancient Andean peoples really did boil and mash potatoes, I came across this post which sheds light on the issues I have with my father’s instant mashed potatoes beyond their phenomenal unpleasantness when eaten. There is a rhetorical sleight of hand happening in this Reddit post title.1 The phrasing implies that chuño resembles modern instant mashed potatoes in some way, that instant mashed potatoes are in some sense continuous with indigenous ways of potato-knowing. But there is no continuity of process, because the way chuño is created has no particular commonalities with the Philadelphia Cook beyond the removal of moisture. There is no continuity of form, for chuño actually looks like this: (source) And there is no continuity of purpose, either. To the Andean peoples, chuño was the only way of ensuring that their potato crops would be available well into the future. In America, our indigenous way of achieving this potato security is the entire miracle of modern agriculture and food distribution. I don’t need to stomp on freeze-dried potatoes in the Altiplano to make sure I’ll have access to potato nutrients next year. I just have to rely on the continued existence of Idaho and Target. No, despite what this redditor would like to believe, the instant mashed potato serves some other purpose. That purpose is illuminated by the second rhetorical sleight of hand in the Reddit post, the one occurring on the box, in the form of the offset between the yellow lower-case “Instant” and the white majuscule “MASHED POTATOES”. “These are fundamentally maſhed potatoes,” this typography lies, “that happen to have been given the quality of ‘instant’”. But they’re not. They’re a different thing entirely, a completely new evolutionary lineage of potato preparation that’s called “instant mashed potatoes” even though they’ve never been mashed. They are as distinct from Glasse’s maſhed potatoes as chuño is, but they masquerade as being the same, because that is their purpose - the fulfillment of a psychological need to consume something resembling the classic dish of “mashed potatoes” with slightly less effort than that dish requires. This is a pedantic distinction - but it’s a distinction that had a big impact on my culinary life, because I believed the lie. My mental category of “mashed potatoes” was hijacked by this impostor and it made me think, for years and years, that I hated something that I actually would have liked all along. My preference formation was distorted by this warped, hyper-optimized fulfillment of my father’s crystallized preference. The expedient way to fulfill one generation’s desire locked the next generation out of experiencing that desire at all. At this point in the review you might say, “what’s the big deal? It’s just mashed potatoes. Chill out.” Which, fair enough - if it were just mashed potatoes then 2500 words on them might be excessive. But the pattern I’ve described is far from unique to pureed tubers. Consider an abstracted version of the saga of my father’s instant mashed potatoes. It has a few steps: Humanity develops a Thing from ingredients that exist in the world.
Inline links: this post, https://substackcdn.com/image/fetch/$s_!GFq8!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fee286622-7cfd-45fa-b18e-6fc06b9fea81_739x919.png, 1, https://substackcdn.com/image/fetch/$s_!dL21!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F4f7f74da-27ee-4ffa-8d76-ea9fa3853394_1280x855.png, source
There is a rhetorical sleight of hand happening in this Reddit post title.1 The phrasing implies that chuño resembles modern instant mashed potatoes in some way, that instant mashed potatoes are in some sense continuous with indigenous ways of potato-knowing. But there is no continuity of process, because the way chuño is created has no particular commonalities with the Philadelphia Cook beyond the removal of moisture. There is no continuity of form, for chuño actually looks like this: (source) And there is no continuity of purpose, either. To the Andean peoples, chuño was the only way of ensuring that their potato crops would be available well into the future. In America, our indigenous way of achieving this potato security is the entire miracle of modern agriculture and food distribution. I don’t need to stomp on freeze-dried potatoes in the Altiplano to make sure I’ll have access to potato nutrients next year. I just have to rely on the continued existence of Idaho and Target. No, despite what this redditor would like to believe, the instant mashed potato serves some other purpose. That purpose is illuminated by the second rhetorical sleight of hand in the Reddit post, the one occurring on the box, in the form of the offset between the yellow lower-case “Instant” and the white majuscule “MASHED POTATOES”. “These are fundamentally maſhed potatoes,” this typography lies, “that happen to have been given the quality of ‘instant’”. But they’re not. They’re a different thing entirely, a completely new evolutionary lineage of potato preparation that’s called “instant mashed potatoes” even though they’ve never been mashed. They are as distinct from Glasse’s maſhed potatoes as chuño is, but they masquerade as being the same, because that is their purpose - the fulfillment of a psychological need to consume something resembling the classic dish of “mashed potatoes” with slightly less effort than that dish requires. This is a pedantic distinction - but it’s a distinction that had a big impact on my culinary life, because I believed the lie. My mental category of “mashed potatoes” was hijacked by this impostor and it made me think, for years and years, that I hated something that I actually would have liked all along. My preference formation was distorted by this warped, hyper-optimized fulfillment of my father’s crystallized preference. The expedient way to fulfill one generation’s desire locked the next generation out of experiencing that desire at all. At this point in the review you might say, “what’s the big deal? It’s just mashed potatoes. Chill out.” Which, fair enough - if it were just mashed potatoes then 2500 words on them might be excessive. But the pattern I’ve described is far from unique to pureed tubers. Consider an abstracted version of the saga of my father’s instant mashed potatoes. It has a few steps: Humanity develops a Thing from ingredients that exist in the world.
Inline links: 1, https://substackcdn.com/image/fetch/$s_!dL21!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F4f7f74da-27ee-4ffa-8d76-ea9fa3853394_1280x855.png, source
Phillips curve1 mentions across 1 issues

Phillips curve is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between May 19, 2023 and May 19, 2023. The archive places it in contexts such as "The Phillips curve in particular became popular"; "Phillips curve : from Phillips, A.W. (1958), The Relation Between Unemployment and the Rate of Change of Money Wage Rates in the United Kingdom, 1861–1957". It most often appears alongside 1980, 1980 referendum, 1995 referendum.

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Phillips curve
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May 19, 2023
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May 19, 2023
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The Question Of Separatism
May 19, 2023 · Original source
This book is Jacobs’s least read. It was published in 1980, right after the first referendum where Quebecers voted to remain a part of Canada. It is based on lectures that Jacobs (who was an American but had moved to Canada in 1968) gave in Toronto right before the referendum. It’s not hard to guess why the book didn’t have a huge (read: any) impact. First, most people outside Quebec or Canada don’t have any reason to care. Second, the essay — which was written in English — argues in favor of the secession of Quebec, which virtually no one among the English-speaking population of Canada agreed with. The natural reaction from Canada’s intelligentsia was to ignore the book altogether. Meanwhile, few people in Quebec itself read it, since the referendum was over; it wasn’t even translated into French until decades later. As a result, The Question of Separatism sits awkwardly in Jane Jacobs’s bibliography, as if it were “a mistake in an otherwise brilliant career,” like I read somewhere. In a 2005 interview, one year before her death, Jacobs said that no journalist ever asked her about it. But the book was not a mistake. I don’t claim any special insight here: Jane Jacobs herself said so in that same interview. She said that she would have written the same book in 2005, “because that’s the way it is in the world, and it still holds.” Besides, The Question of Separatism is in fact not that much about the specifics of Quebec’s political situation, but rather about interesting generalities: what size means for countries and organizations, and why the fate of nations depends primarily on what happens in their cities. Taken together with Cities and the Wealth of Nations, which Jacobs wrote a few years later to expand on those ideas, we get a coherent and deeply interesting philosophy of economics: one that favors the local scale, cities and small countries, antifragility long before Nassim Taleb coined the term, and avoiding grandstanding theories that always fail to take into account the real complexity of the world. I. A Fake Mystery Cities and the Wealth of Nations opens on an economic mystery. “For a little while in the middle of this century,” writes Jacobs, “it seemed that the wild, intractable, dismal science of economics had yielded up something we all want: instructions for getting or keeping prosperity.” This was the 1940s to 1960s, and economists thought they had it all figured out. It was the golden age of high modernism and scientific technocracy. Everywhere from China to the Soviet Union to the United States and Britain and the nascent European Economic Community, leaders were coming up with elaborate plans, rooted in macroeconomic theories, that were supposed to guarantee future wealth and avoid economic crises. The theories had been developed by many thinkers over the previous two hundred years: Richard Cantillon, Adam Smith, John Stuart Mill, Karl Marx, John Maynard Keynes. Jacobs explains how they each had their own ideas of how the economy worked, disagreeing over things like whether supply or demand was the main driving mechanism, but they all agreed on a fundamental fact: inflation and unemployment have an inverse relationship to each other, like a seesaw. High inflation comes with low unemployment; high unemployment comes with low inflation, or even deflation when prices drop. The Great Depression, a time of deflation, had provided proof of the seesaw. Big government projects, as prescribed by Keynesians, were a way for states to reduce unemployment and bring the seesaw back in a balanced state. Economists developed fancy models, based on historical data, to predict the behavior of the economy. The Phillips curve in particular became popular. It was the golden age of technocracy; it was the triumph of high modernism. From now on wealth was assured, because we weren’t blind anymore: we had the curves. And yet — by the 1970s and 1980s, when Jane Jacobs was writing, the theories all stopped working. There was high inflation and high unemployment. People called it stagflation. Keynesian advisers in various governments were devastated: either their ideas were wrong, or they were applying them wrong. Economists such as Milton Friedman, from a rival school of economists called the monetarists or the Chicago school, came to the rescue — but their remedy, Jacobs believes, only made things worse. Whatever governments did to increase employment made inflation worse; whatever they did to attenuate inflation killed employment. The seesaw from the theories was working in application, even though it didn’t explain reality anymore. Stagflation was not supposed to exist, so stagflation could not be fought. At this point we’re near the end of Chapter 1, the densest part of the book. Jacobs has artfully guided us along economic history and laid out the mystery for us. What’s going on? we wonder. How are we supposed to deal with the two-headed monster of stagflation, if all economists are stumped? Then Jacobs, in a masterstroke, flips the whole thing over. I was impressed enough that I would have inserted a spoiler alert here, if it didn’t feel so silly putting a spoiler alert in an essay on economics. Stagflation is not a strange monster from legend. It is, Jacobs says, just the normal state of everything. Backward economies are in fact constantly in a state of stagflation. The prices in a poor country like Portugal or India (her two examples) feel low for an American or Canadian, but they’re high for most Portuguese or Indian people. At the same time, Portugal and India provide too few jobs to their residents. Inflation and unemployment are both perennially high, and none of that feels surprising whatsoever. Stagflation, in short, is just good ol’ poverty. All these fancy economists, from Cantillon in 1700s France to Keynes and Friedman in the 20th century Anglosphere, were thinking and writing about unusual places: rich countries that were undergoing fast economic development. They were making the classic mistake of treating poverty as a mystery and wealth as a given, when in fact poverty is the normal order of things and wealth, when it does occur, is what warrants an explanation. The result is that we don’t really know how to fix the economy of poor countries, nor do we know how to deal with decline in rich countries, whether we call it stagflation or something else. Jacobs derives from this a pretty damning view of macroeconomics. It is to her a science that has failed again and again, each time engulfing the equivalent of billions of dollars in wasted wealth. “We must,” she writes at the close of Chapter 1, “find more realistic and fruitful lines of observation and thought than we have tried to use so far. It is bootless to choose among existing schools of thought. We are on our own.” Fortunately, she has some ideas. II. Nations and the Wealth of Cities The original sin of macroeconomics, Jacobs believe, is to treat sovereign countries, or nations, as the main unit of economic analysis. This error, she claims, goes back to mercantilism, one of the first formal economic policies. Oversimplified, mercantilism states that wealth is synonymous with the amount of gold and silver in a nation’s treasury. This makes nations the main unit of economic analysis by definition. It’s a tautology — and one that was somehow embedded so deep in economic thinking that even the non-mercantilist Adam Smith would eventually choose, for his masterpiece of economic theory, the title An Inquiry into the Nature and Causes of the Wealth of Nations. Today, even though mercantilism has long been obsolete, we perpetuate the same tautology whenever we talk of the Gross Domestic Product or look at the very nice charts from Our World in Data, which for the most part allow only one level of resolution: sovereign countries. Of course, nations are an economically important concept because of that one property: they are sovereign, and therefore they write laws and implement policies that affect the economy. These policies can be productively compared. But that’s about it — for everything else, nations aren’t the right way to think about wealth. One reason is simply that they’re very different from one another: “it affronts common sense,” Jacobs writes, “to think of units as disparate as, say, Singapore and the United States, or Ecuador and the Soviet Union, or the Netherlands and Canada, as economic common denominators.” I would add that countries are arbitrary and changing: when the Soviet Union was replaced by 15 sovereign countries, the economic reality didn’t suddenly reshape itself to match the new borders. Lastly, nations contain, under the hood, many sub-economies that are also highly different from one another. None of that is secret or forbidden knowledge. Everyone has always been aware that New York City, or Milan, are economically very different from rural Mississippi or Sicily. But I find that it’s far easier to think in terms of “the United States” or “Italy,” especially when you’re not from there. Nations are an abstraction of real-life complexity, and are accordingly very tempting to use. Also, they’re often the entities that collect statistics, which is another difficult-to-resist temptation for anyone who likes quantitative data. Cities as Radiators of Economic Forces If nations aren’t the best unit to analyze the economy, what is? This is a Jane Jacobs book, so the answer is obviously going to be cities. Jacobs doesn’t actually give a clear argument why. Maybe that was in her previous book, The Economy of Cities. So far as I can see, her reasoning is, ironically, a bit tautological: “all developing economic life depends on city economies; it depends on them by definition because, wherever economic life is developing, the very process itself creates cities and has probably always done so.” But so far as I can see, this reasoning is correct. Cities concentrate people, and therefore economic life, and therefore economic power. The driving force for all this is a phenomenon that, from what I gather, was discovered by Jacobs when she wrote The Economy of Cities: import replacement. Consider, say, Boston back when it was a tiny settlement, not yet a city, in colonial times. At first, Boston didn’t produce much, especially not much that would be of interest to its main trading partner, London. It exported some natural resources: timber, fish. Whatever else the Bostonians needed, they needed to import it from other cities, again mostly London. (Remember to think of imports and exports in terms of cities, not nations.) For instance, at first, all metal tools in Boston came from European cities, and were paid for by the revenue from selling the timber and fish. Then, one day, some Bostonians decided to build an ironworks and make metal tools themselves. (Pictured: a reconstruction of the Saugus Iron Works, established 1646.) This wasn’t of any interest to London or other European cities. The Bostonians weren’t nearly as good or efficient at making metal tools as Londonians were. So Boston couldn’t export the metal tools back to Europe — but it could use them internally, and also export them to other American cities that were about as poor as Boston was, or poorer. Internally, this meant the spark of a manufacturing economy in Boston, as easily obtained metal parts made it easier for other Bostonians to replace other imports from European cities, and eventually develop a symbiotic network of industries. It also meant that the revenue from fish and timber could be used to import new things, including new innovations from European cities (which would later become opportunities for more import replacement). And because there were customers for Boston-made metal goods in New York and Philadelphia, and eventually Cincinnati and Chicago and Pittsburgh as these cities came into existence, it meant additional revenue for Boston that it could reinvest into developing its production further. For Jacobs, virtually all city development can be seen through the lens of import replacement (which, to be clear, has approximately nothing to do with policies of import substitution industrialization; import replacement is not a policy, but a naturally arising free market phenomenon). Her book contains many other examples than Boston, such as Venice, which started off in the early Middle Ages as a small town that sold salt to Constantinople, but then diversified its production to become one of the wealthiest cities of its time; or Taipei and Kaohsiung, two cities in Taiwan that kickstarted their development not long before the 1980s, by forcing expropriated landlords to invest into local import-replacing businesses. One is reminded of Scott’s review of How Asia Works. Import replacement, then, is what makes cities economically powerful. And this power is so great that it causes ripples in distant places. In fact it is the main reason that anything happens at all in non-city areas. Jacobs gives the example of Bardou, a small village in southern France. Bardou looks like this: To the extent that Bardou ever had an economic life, that life was almost entirely driven by distant cities. In ancient times, the area was populated because of iron mines nearby. The mines were exploited to serve the needs of people in the distant cities of Lugdunum (Lyon), Nemausus (Nîmes), or even Rome. As Jacobs notes, we could say that the mines served “the Roman Empire,” but that would be another example of using the abstraction of sovereign countries when we should instead be specific. It was Lugdunum, Nemausus and Rome that wanted the iron — not some random rural area of the empire, and certainly not the part of the empire in which Bardou was located. Eventually the mines and the region were abandoned. More than 1,000 years later, peasants moved into the area and built the modern village. For centuries they lived a wretchedly poor life of subsistence farming. No cities exerted any influence on it, and indeed nothing happened. Then, in the 19th century, the people of Bardou learned that they could improve their situation by moving to distant cities such as Paris, and most of them did. Again, the force wasn’t being exerted by “France”; Bardou was already part of France. The force was specifically being exerted by Paris and other cities with jobs for poor peasants. By the 1960s, only one old man was left. That’s when two foreign visitors, a German and an American, happened upon the village, decided to buy most of it, revitalized it, and turned it into a tourist spot (and even, for a brief time, into a set for a movie company). Today Bardou is a popular place for travelers — who are mostly city people, and spend money that was mostly earned in cities. The Bardou story contains examples of several of the forces that import-replacing cities radiate, according to Jacobs. These forces are central to her thinking. There are five of them: Markets. Cities house a lot of people who need a lot of goods and services, and are therefore strong markets to sell goods and services to. This was the force that acted on the Bardou area when it was a Roman mining region, and again today when it functions as a tourist spot for city vacationers.
Inline links: Phillips curve, https://substackcdn.com/image/fetch/$s_!9wEn!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F850ce64a-4367-4a7a-a9ec-e8eb1af3ed08_399x292.png, Our World in Data, https://substackcdn.com/image/fetch/$s_!zS15!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F7d533e64-f407-4b05-aea5-5b5a9dbdc7bc_1600x1130.png, import replacement, https://substackcdn.com/image/fetch/$s_!5j2T!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F7f2675d9-ce56-4ac5-9b78-a16720269dea_1600x1159.png, import substitution industrialization, Scott’s review of, Bardou, https://substackcdn.com/image/fetch/$s_!RfMs!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fc119b085-f7b3-4e09-a586-9f4fc4c2ea21_1200x1600.png
Phillips curve: from Phillips, A.W. (1958), The Relation Between Unemployment and the Rate of Change of Money Wage Rates in the United Kingdom, 1861–1957. Economica, 25: 283-299. https://doi.org/10.1111/j.1468-0335.1958.tb00003.x
Inline links: https://doi.org/10.1111/j.1468-0335.1958.tb00003.x
Philos1 mentions across 1 issues

Philos is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between September 29, 2022 and September 29, 2022. The archive places it in contexts such as "move on to categories like Art, Crypto, Philos". It most often appears alongside 1 Kings 10-11, 2008 Democratic National Convention, Adam Scheffer.

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Philos
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Universe-Hopping Through Substack
September 29, 2022 · Original source
Let me emphasize, here at the outset of our journey, that this is a much bigger issue than just one man and his magical songs. A key argument of this book is that the shape of Western society even today is the result of a battle in worldviews that took place 2,500 years ago. On the one side, you had the proponents of logic, rationality, and philosophy, and they defeated their opponents who put their faith in songs.
It is, at least, as many Substacks as I am willing to evaluate in a single sitting. Join us next time, as we hopefully move on to categories like Art, Crypto, Philosophy, and Fashion.
Philosophic1 mentions across 1 issues

Philosophic is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between July 14, 2023 and July 14, 2023. The archive places it in contexts such as "Egan dubs “Philosophic” understanding"; "Mythic, then Romantic, then Philosophic"; "A person in Philosophic thinks we build beliefs the way a mason builds a house". It most often appears alongside !Kung San, aboriginal people on the west coast of Canada, Adam Smith.

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Philosophic
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Your Book Review: The Educated Mind
July 14, 2023 · Original source
The kind of understanding we laid out for high school was first hammered out by Plato and Aristotle, went dormant in Europe, and was further developed by Arab & Jewish scholars before blossoming again in the Renaissance and Enlightenment. Nowadays it’s carried on by scholars in more-or-less every university department. Egan needed a name that would encompass all of that, and he picked “Philosophic”.
Robin Kimmerer, professor of biology, member of the Potawatomi tribe, and author of the bestselling Braiding Sweetgrass, pointed out that what Egan dubs “Philosophic” understanding is limited:
Inline links: pointed out
But the question does call our attention to something odd — why should it be that there’s any connection between children and indigenous knowledge? To answer that, we need to ask a bigger question: where did Philosophic come from in the first place?
Philosophic understanding1 mentions across 1 issues

Philosophic understanding is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between July 14, 2023 and July 14, 2023. The archive places it in contexts such as "Philosophic understanding is all about the abstract, the general, the decontextualized"; ""I jumped into Philosophic understanding by becoming a young-earth creationist"". It most often appears alongside !Kung San, aboriginal people on the west coast of Canada, Adam Smith.

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Your Book Review: The Educated Mind
July 14, 2023 · Original source
There’s something missing… and Egan thinks we find it in the emotion-laden, unsystematic, wonder-struck kind of writing that he says spread through Greece in the early years of the Greek Miracle. This looks for all the world like a mash-up of Mythic and Philosophic understanding. It’s best exemplified, Egan writes, in The Histories, by Herodotus — a sort of “Guinness Book of Ancient World Records. But you don’t need to take Egan’s word for it — here’s the historian (and vampire novelist) Tom Holland, being interviewed by Tyler Cowen:
Inline links: being interviewed by Tyler Cowen
You might assume that the Rationalist community is squarely in Philosophic understanding — and I think that’s mostly right. Just looking at Eliezer's “Twelve Virtues of Rationality”, I’m seeing argument, empiricism, simplicity, precision, and scholarship — pitch-perfect expressions of what Egan means by “Philosophic” understanding.
Inline links: Twelve Virtues of Rationality
I think you see it, for example, in the community’s penchant for yelling “Chesterton’s Fence!” whenever anyone criticizes something they don’t understand. Philosophic understanding is obsessed with things making sense; Ironic understanding says, reality is always a few steps beyond you. “Chesterton’s Fence” is a Rationalist shorthand for the idea that we should expect the world to be more complex than our models; if something looks stupid, you should consider that the stupidity may be in you.
Philosophy1 mentions across 1 issues

Philosophy is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between September 29, 2022 and September 29, 2022. The archive places it in contexts such as "categories like Art, Crypto, Philosophy, and Fashion". It most often appears alongside 1 Kings 10-11, 2008 Democratic National Convention, Adam Scheffer.

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Universe-Hopping Through Substack
September 29, 2022 · Original source
Let me emphasize, here at the outset of our journey, that this is a much bigger issue than just one man and his magical songs. A key argument of this book is that the shape of Western society even today is the result of a battle in worldviews that took place 2,500 years ago. On the one side, you had the proponents of logic, rationality, and philosophy, and they defeated their opponents who put their faith in songs.
It is, at least, as many Substacks as I am willing to evaluate in a single sitting. Join us next time, as we hopefully move on to categories like Art, Crypto, Philosophy, and Fashion.
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Philosophy 101 Thought Experiment is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between October 27, 2023 and October 27, 2023. The archive places it in contexts such as "In a Philosophy 101 Thought Experiment sense". It most often appears alongside 1DaySooner, ACX, Africa.

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My Left Kidney
October 27, 2023 · Original source
This isn’t controlling for selection bias - but neither was my uncle’s anecdotal observation. So although it does make me slightly nervous, I’m not going to treat it as actionable evidence. Still, my girlfriend ending up begging me not to donate, and I caved. But we broke up in 2019. The next few years were bumpy, but by 2022 my life was in a more stable place and I started thinking about kidneys again. By then I was married. I discussed the risks with my wife and she decided to let me go ahead. So in early November 2022, for the second time, I sent a form to the University of California San Francisco Medical Center saying I wanted to donate a kidney. IV. Something else happened that month. On November 11, FTX fell apart and was revealed as a giant scam. Suddenly everyone hated effective altruists. Publications that had been feting us a few months before pivoted to saying they knew we were evil all along. I practiced rehearsing the words “I have never donated to charity, and if I did, I certainly wouldn’t care whether it was effective or not”. But during the flurry of intakes, screenings, and evaluations that UCSF gave me that month, the doctors asked “so what made you want to donate?” And I hadn’t rehearsed an answer to this one, so I blurted out “Have you heard of effective altruism?” I expected the worst. But the usual response was “Oh! Those people! Great, no further explanation needed.” When everyone else abandoned us, the organ banks still thought of us as those nice people who were always giving them free kidneys. We were giving them a lot of free kidneys. When I talked to my family and non-EA friends about wanting to donate, the usual reaction was “You want to what?!” and then trying to convince me this was unfair to my wife or my potential future children or whatever. When I talked to my EA friends, the reaction was at least “Cool!”. But pretty often it was “Oh yeah, I donated two years ago, want to see my scar?” Most people don’t do interesting things unless they’re in a community where those things have been normalized. I was blessed with a community where this was so normal that I could read a Vox article about it and not vomit it back out. This is surprising, because kidney donation is only medium effective, as far as altruisms go4. The average donation buys the recipient about 5 - 7 extra years of life (beyond the counterfactual of dialysis). It also improves quality of life from about 70% of the healthy average to about 90%. Non-directed kidney donations can also help the organ bank solve allocation problems around matching donors and recipients of different blood types. Most sources say that an average donated kidney creates a “chain” of about five other donations, but most of these other donations would have happened anyway; the value over counterfactual is about 0.5 to 1 extra transplant completed before the intended recipient dies from waiting too long. So in total, a donation produces about 10 - 20 extra quality-adjusted life years. This is great - my grandfather died of kidney disease, and 10 - 20 more years with him would have meant a lot. But it only costs about $5,000 - $10,000 to produce this many QALYs through bog-standard effective altruist interventions, like buying mosquito nets for malarial regions in Africa. In a Philosophy 101 Thought Experiment sense, if you’re going to miss a lot of work recovering from your surgery, you might as well skip the surgery, do the work, and donate the extra money to Against Malaria Foundation instead5. Obviously this kind of thing is why everyone hates effective altruists. People got so mad at some British EAs who used donor money to “buy a castle”. I read the Brits’ arguments: they’d been running lots of conferences with policy-makers, researchers, etc; those conferences have gone really well and produced some of the systemic change everyone keeps wanting. But conference venues kept ripping them off, having a nice venue of their own would be cheaper in the long run, and after looking at many options, the “castle” was the cheapest. Their math checked out, and I believe them when they say this was the most effective use for that money. For their work, they got a million sneering thinkpieces on how “EA just takes people’s money to buy castles, then sit in them wearing crowns and waving scepters and laughing at poor people”. I respect the British organizers’ willingness to sacrifice their reputation on the altar of doing what was actually good instead of just good-looking. I worry that people use suffering as a heuristic for goodness. Mother Teresa becomes a hero because living with lepers in the Calcutta slums sounds horrible - so anyone who does it must be really charitable (regardless of whether or not the lepers get helped). Owning a castle is the opposite of suffering - it sounds great - therefore it is fake charity (no matter how much good you do with the castle). This heuristic isn’t terrible. If you’re suffering for your charity, then it must seem important to you, and you’re obviously not doing it for personal gain. If you do charity in a way that benefits you (like gets you a castle), then the personal gain aspect starts looking suspicious. The problem is the people who elevate it from a suspicion to an automatic condemnation. It seems like such a natural thing to do. And it encourages people to be masochists, sacrificing themselves pointlessly in photogenic ways, instead of thinking about what will actually help others. But getting back to the point: kidney donation has an unusually high ratio of photogenic suffering to altruistic gains. So why do EAs keep doing it? I can’t speak for anyone else, but I’ll speak for myself. It starts with wanting, just once, do a good thing that will make people like you more instead of less. It would be morally fraught to do this with money, since any money you spent on improving your self-image would be denied to the people in malarial regions of Africa who need it the most. But it’s not like there’s anything else you can do with that spare kidney. Still, it’s not just about that. All of this calculating and funging takes a psychic toll. Your brain uses the same emotional heuristics as everyone else’s. No matter how contrarian you pretend to be, deep down it’s hard to make your emotions track what you know is right and not what the rest of the world is telling you. The last Guardian opinion columnist who must be defeated is the Guardian opinion columnist inside your own heart. You want to do just one good thing that you’ll feel unreservedly good about, and where you know somebody’s going to be directly happy at the end of it in a way that doesn’t depend on a giant rickety tower of assumptions. Dylan Matthews wrote: As I’m no doubt the first person to notice, being an adult is hard. You are consistently faced with choices — about your career, about your friendships, about your romantic life, about your family — that have deep moral consequences, and even when you try the best you can, you’re going to get a lot of those choices wrong. And you more often than not won’t know if you got them wrong or right. Maybe you should’ve picked another job, where you could do more good. Maybe you should’ve gone to grad school. Maybe you shouldn’t have moved to a new city. So I was selfishly, deeply gratified to have made at least one choice in my life that I know beyond a shadow of a doubt was the right one. …and it really resonated. Everything else I try to do, there’s a little voice inside of me which says “Maybe the haters are right, maybe you’re stupid, maybe you’re just doing the easy things. Maybe you’re no good after all, maybe you’ll never be able to figure any of this out. Maybe you should just give up.” The Talmud is very clear: that voice is called the evil inclination, and it dwells in the left kidney. There is only one way to shut it off forever. I was ready. V. You might not be a masochist. But hospitals are sadists. They want to hear you beg. After I submitted the donation form, I was evaluated by a horde of indistinguishable women. They all had titles like “Transplant Coordinator”, “Financial Coordinator”, and “Patient Care Representative”. Several were social workers; one was a psychiatrist. They would see me through a buggy version of Zoom that caused various parts of their body to suddenly turn into the UCSF logo, and they all had questions like “Are you sure you want to do this?” and “Are you going to regret this later?” and “Is anyone pressuring you to do this?” and “Are you sure you want to do this?” After clearing that gauntlet came the tests. Blood tests - I think I must have given between 20 and 50 vials of blood throughout the screening process. Urine tests - both the normal kind where you pee in a cup, and a more involved kind where you have to store all your urine for 24 hours in a big jug, then take it to the lab. “Urinate into a jug” ought to be the easiest thing in the world, but some of the labs have overly complicated jugs that I, with my mere MD, couldn’t always get right - hence my experience accidentally pouring urine on myself in an Uber. Then came the big guns. Echocardiogram. MRI. One of my urine tests was slightly off, so I also got a nuclear kidney scan, where they injected radioactive liquid in me and monitored how long it took to come out the other end (I remember asking a friend “Can I use your bathroom? My urine might be slightly radioactive today, but it shouldn’t be enough to matter.”) Finally, five months after I originally applied, I got a phone call from the Transplant Coordinator. The test results were in, and . . . I had been rejected because I’d had mild childhood OCD. This was something I’d mentioned offhandedly during one of the psych evaluations. As a child, I used to touch objects in odd patterns that only made sense to me. I got diagnosed with OCD, put on SSRIs for a while, finally did therapy at age 15, hadn’t had any problems since. I still go back on SSRIs sometimes when I’m really stressed, and will grudgingly admit to the occasional odd-pattern-touching when no one’s looking. But it’s nothing anyone would know about if I didn’t tell them! It was mild even at age 15, and it’s been close-to-nonexistent for the past twenty years! Now I’m a successful psychiatrist who owns his own psychiatry practice and helps other people with the condition! I told them all this. They didn’t care. I asked them if there was anything I could do. They said maybe I could go to therapy for six months, then apply again. I asked them what kind of therapy was indicated for mild OCD that’s been in remission for twenty years. They sounded kind of surprised to learn there were different types of therapy and said whatever, just talk to someone or something. I asked them how frequent they thought the therapy needed to be. They sounded kind of surprised to learn that therapy could have different frequencies, and said, you know, therapy, the thing where you talk to someone. I asked them if they actually knew anything about OCD, psychotherapy, or mental health in general, or if they had just vaguely heard rumors that some people were bad and crazy and shouldn’t be allowed to make their own decisions, and that a ritual called “therapy” could absolve one of this impurity. They responded as politely as possible under the circumstances, but didn’t change their mind. I wasn’t going to waste an hour a week for six months, and spend thousands of dollars of my own extremely-not-reimbursed-by-UCSF money, to see a randomly-selected therapist for a condition I’d gotten over twenty years ago, just so I could apply again and get rejected a second time. This was one of the most infuriating and humiliating things that’s ever happened to me. We throw around a lot of terms like “stigma” and “paternalism”, and I’ve worked with patients who have dealt with all these issues (it’s UCSF in particular a surprising amount of the time!). But I was still surprised how much it hurt when it happened to me. Being denied the right to control your own body because of some meaningless diagnosis on a chart somewhere is surprisingly frustrating, even compared to things that should objectively be worse. I thought I was going to be able to do a good deed that I’d been fantasizing about for years, and some jerk administrator torpedoed my dreams because I had once, long ago, had mild mental health issues. So I gave up. I spent the next few weeks unleashing torrents of anti-UCSF abuse at anyone who would listen. This turned out to be very productive! When I was unleashing a torrent of anti-UCSF abuse to Josh Morrison of WaitlistZero, he asked if I’d tried other hospitals. I hadn’t. I’d assumed they were all in cahoots. But Josh said no, each hospital had their own evaluation process. Weill Cornell, a hospital in NYC, was one of the best transplant centers in the country, and had a reputation for fair and thoughtful pre-donor screening. Why didn’t I talk to them? NYC was far away, and I hate to travel, but I was just angry enough to accept. At this point I’d forgotten whatever good altruistic motivations I might have originally had and was fueled entirely by spite. Getting my kidney taken out somewhere else felt like it would be a sort of victory over UCSF. So I went for it. Cornell was lovely. They tried to do as much of the process as they could via Californian intermediaries, so that I only had to fly to New York twice. Their psychiatrist evaluated me, listened to me explain my weak history of OCD, then treated me like a reasonable adult who tells the truth and can handle his own medical decisions. They were concerned that I sometimes self-prescribed Lexapro to deal with anxiety. But we agreed on a compromise: I found another psychiatrist, let her give me the exact same prescription of Lexapro at a much higher cost to my insurance, and that resolved the problem. So in late September 2023 - ten months after I started the process - I finally got fully cleared to donate, surgery set for October 12. VI. I knew, in theory, that anaesthetics existed. Still, it’s weird. One moment you’re lying on a table in the OR, steeling yourself up for one of the big ordeals of your life. The next, you’re in a bed in the recovery room, feeling fine. The operation - this thing you’ve been thinking about and dreading for months - exists only as a lacuna in your memory. Not even some kind of fancy lacuna, where you remember the darkness closing in on you beforehand, or have to claw yourself back into consciousness afterwards. The most ordinary of lacunas, like a good night sleep. There was no pain, not at first. The painkillers and nerve blocks lasted about a day after the surgery. By the time they wore off, it was more of a dull ache. The hospital offered me Tylenol, and I wanted to protest - really? Tylenol? After major surgery? But the Tylenol worked. Some people will have small complications (I am a doctor, pretty jaded, and my definition of “small” may be different from yours). Dylan Matthews wrote about an issue where his scrotum briefly inflated like a balloon (probably this is one of the ones that doesn’t feel small when it’s happening to you). I missed out on that particular pleasure, but got others in exchange. I had an unusually hard time with the catheter - the nurse taking it out frowned and said the team that put it in had “gone too deep”, as if my urinary tract was the f@#king Mines of Moria - but that was fifteen seconds of intense pain. Then a week afterwards, just when I thought I’d recovered fully, I got bowled over by a UTI which knocked me out for a few days. But overall, I was surprised by the speed and ease of my recovery. A few hours after the surgery, I walked a few steps. After a day, I got the catheter out and could urinate normally again. After two days, I was eating “SmartGel”, a food substitute that has mysteriously failed to catch on outside of the immobilized-hospital-patient market. After three, I was out of the hospital. After four, I started easing myself back into (remote) work. After a week, I flew cross-country. . . . and then I got the UTI. If this section sounds schizophrenic, it’s because it’s a compromise between an original draft where I said nothing went wrong and it was amazing, and a later draft written after a haze of bladder pain. Just don’t develop complications, that’s my advice. Still, I recently heard from the surgeon that my recipient’s side of the surgery was a success, that my kidney was in them and going fine - and that put things back into perspective. To a first approximation, compared to the inherent gravity of taking an organ out of one person and putting it in a second person and saving their life - it was all easy and everything went well. When I look back on this in a decade, I’ll remember it as everything being easy and going well. Even now, with some lingering bladder pain, modern medicine still feels like a miracle. VII. In polls, 25 - 50% of Americans say they would donate a kidney to a stranger in need. This sentence fascinates me because of the hanging “would”. Would, if what? A natural reading is “would if someone needs it”. But there are 100,000 strangers on the waiting list for kidney transplants. Between 5,000 and 40,000 people die each year for lack of sufficient kidneys to transplant. Someone definitely needs it. Yet only about 200 people (0.0001%) donate kidneys to strangers per year. Why the gap between 25-50% and 0.0001%? Some of you will suspect respondents are lying to look good. But these are anonymous surveys. Lying to themselves to feel good, then? Maybe. But I think about myself at age 20, a young philosophy major studying utilitarianism. If someone had asked me a hypothetical about whether I would donate a kidney to a stranger in need, I probably would have said yes. Then I would have continued going about my business, never thinking of it as a thing real-life people could do. Part of this would have been logistics. I wouldn’t have known where to start. Do you need to have special contacts in the surgery industry? Seek out a would-be recipient on your own? Where would you find them? But more of it would have been psychological: it just wasn’t something that the people I knew did, and it would be weird and alienating for me to be the only one. This is going to be the preachy “and you should donate too!” section you were dreading all along, but I’m not going to make a lot of positive arguments. If 90% of the people who answer yes on those surveys are lying to feel good, then only 3 - 5% really want to donate. But bringing the donation rate from 0.0001% of people to 3 - 5% of people would solve the kidney shortage many times over. The point isn’t to drag anti-donation-extremists kicking and screaming to the operating table. The point is to reach the people who already want to do it, and make them feel comfortable starting the process. 20-year-old me was in that category. The process of making him feel comfortable involved fifteen years of meeting people who already done it. During residency, I met a fellow student doctor who had donated. Later, I got involved in effective altruism, and learned that movement leader Alexander Berger - a guy who can easily direct millions of dollars at whatever cause he wants - had donated his personal kidney as well. Some online friends. Some people I met at conferences. And Dylan Matthews, who I kept crossing paths with (most recently at the Manifest journalism panel). After enough of these people, it no longer felt like something that nobody does, and then I felt like I had psychological permission to do it. (obviously saints can do good things without needing psychological permission first, but not everyone has to be in that category, and I found it easier to get the psychological permission than to self-modify into a saint6.) So I’m mostly not going to argue besides saying: this is a thing I did, it’s a thing hundreds of other people do each year, getting started is as simple as filling out a form, and if it works for you, you should go for it7. When I woke up in the recovery room after surgery, I felt great. Amazing. Content, peaceful, proud of myself. Mostly this was because I was on enough opioids to supply a San Francisco homeless encampment for a month. But probably some of it was also the warm glow of having made a difference or something. That could be you! VIII. The ten of you who will listen to this and donate are great. That brings the kidney shortage down from 40,000 to 39,990/year. Everyone knows we need a systemic solution, and everyone knows what that solution will eventually have to be: financial compensation for kidney donors. But so far they haven’t been able to get together enough of a coalition to overcome the usual cabal of evil bioethicists who thwart every medical advance. My kidney donation “mentor”8 Ned Brooks is starting a new push - the Coalition To Modify NOTA - which proposes a $100,000 refundable tax credit - $10,000 per year for 10 years - for kidney donors. There would be a waiting period and you’d have to get evaluated first, so junkies couldn’t walk in off the street and get $100K to spend on fentanyl. No intermediate company would “profit” off the transaction, and rich people wouldn’t be able to pay directly to jump in line. It would be the same kidney donation system we have now, except the donors get $100,000 back after saving the government $1MM+. (the libertarian in me would normally prefer a free market, but “avoid taxes by selling your organs” also has a certain libertarian appeal) This came up often when I talked to other donors. They all had various motivations, but one of the things they cared about was being able to advocate for these kinds of systemic changes more effectively. I personally have been wanting to push this in an essay here for a while, but it seemed hypocritical to play up the desperate kidney shortage while I still had two kidneys. Now I can support NOTA modification whole-heartedly . . . full-throatedly? . . . it’s weird how many of these adverbs involve claims to still have all of your organs. This is also one of the answers to the question I asked in section IV: how do you balance acts of heroic altruism that everyone will love you for vs. acts of boring autistic altruism that will make everyone hate you, but which will accomplish more good in the end?) Coalition To Modify NOTA is full of previous living kidney donors, who are using the moral clout and recognition they’ve gotten to get attention and change the system in an unglamorous way. I find this an admirable way of squaring the circle: do the flashy heroic things to gain social capital, then spend the social capital on whatever’s ultimately most important. If you get one takeaway from this, let it be that those guys who bought the castle were good guys. Two takeaways, and it’s that plus modify NOTA. Three takeaways, and you should feel permission to (if you want) donate a kidney. You can sign up here.9 Feel free to email me at scott@slatestarcodex.com if you have questions about the process. 1Further perspective: I’m 38, which gives me a 2/million total chance of dying per day. So the likelihood that I would die during my kidney operation equals the likelihood that I would die during a randomly chosen two months of everyday life. 2Maybe, kind of. Our knowledge of how radiation causes cancer comes primarily from Hiroshima and Nagasaki; we can follow survivors who were one mile, two miles, etc, from the center of the blast, calculate how much radiation exposure they sustained, and see how much cancer they got years later. But by the time we’re dealing with CAT scan levels of radiation, cancer levels are so close to background that it’s hard to adjust for possible confounders. So the first scientists to study the problem just drew a line through their high-radiation data points and extended it to the low radiation levels - ie if 1 Sievert caused one thousand extra cancers, probably 1 milli-Sievert would cause one extra cancer. This is called the Linear Dose No Threshold (LDNT) model, and has become a subject of intense and acrimonious debate. Some people think that at some very small dose, radiation stops being bad for you at all. Other people think maybe at low enough doses radiation is good for you - see this claim that the atomic bomb “elongated lifespan” in survivors far enough away from the blast. If this were true, CTs probably wouldn’t increase cancer risk at all. I didn’t consider myself knowledgeable enough to take a firm position, and I noticed eminent scientists on both sides, so I am using the more cautious estimate here. 3I told them I had an aunt who died of radiation-induced cancer. It’s true, but I feel grubby for bringing her into this; I thought doctors would be more likely to listen to an emotional story than cold logic. 4EAs have been debating the exact effectiveness of kidney donations for a long time. You can find good skeptical arguments by Jeff Kaufman and Derek Shiller, and good arguments in favor by Alexander Berger and Tom Ash. 5Outside of Philosophy 101 thought experiments, there’s a nonprofit that will often reimburse you for lost wages from your donation. 6Self-modifying into a person who can act boldly without social permission is a more general solution and has many other advantages. But the long version involves living a full life of accumulating moral wisdom, and the short version starts with removing guardrails that are there for good reasons. 7But here are some practical points you might not already appreciate: You shouldn’t have to pay much money. If, like me, you need to travel (eg to New York), kidney related charities will reimburse your travel costs (in theory, I haven’t yet proven this, and a few costs were illegible and I decided not to submit them).
Inline links: bumpy, 4, 5 - 7 extra years of life, improves quality of life, creates a “chain”, $5,000 - $10,000, 5, sacrifice their reputation on the altar of doing what was actually good instead of just good-looking, WaitlistZero, https://substackcdn.com/image/fetch/$s_!7c71!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F08cf5218-6398-4dfb-91a3-d5fc7989b754_765x642.png, polls, 5,000, 40,000, Manifest journalism panel, 6, filling out a form, 7, usual, 8, the, here, 9, 1, 2, Linear Dose No Threshold, this claim, 3, 4, Jeff Kaufman, Derek Shiller, Alexander Berger, Tom Ash, 5, 6, 7
So in late September 2023 - ten months after I started the process - I finally got fully cleared to donate, surgery set for October 12. VI. I knew, in theory, that anaesthetics existed. Still, it’s weird. One moment you’re lying on a table in the OR, steeling yourself up for one of the big ordeals of your life. The next, you’re in a bed in the recovery room, feeling fine. The operation - this thing you’ve been thinking about and dreading for months - exists only as a lacuna in your memory. Not even some kind of fancy lacuna, where you remember the darkness closing in on you beforehand, or have to claw yourself back into consciousness afterwards. The most ordinary of lacunas, like a good night sleep. There was no pain, not at first. The painkillers and nerve blocks lasted about a day after the surgery. By the time they wore off, it was more of a dull ache. The hospital offered me Tylenol, and I wanted to protest - really? Tylenol? After major surgery? But the Tylenol worked. Some people will have small complications (I am a doctor, pretty jaded, and my definition of “small” may be different from yours). Dylan Matthews wrote about an issue where his scrotum briefly inflated like a balloon (probably this is one of the ones that doesn’t feel small when it’s happening to you). I missed out on that particular pleasure, but got others in exchange. I had an unusually hard time with the catheter - the nurse taking it out frowned and said the team that put it in had “gone too deep”, as if my urinary tract was the f@#king Mines of Moria - but that was fifteen seconds of intense pain. Then a week afterwards, just when I thought I’d recovered fully, I got bowled over by a UTI which knocked me out for a few days. But overall, I was surprised by the speed and ease of my recovery. A few hours after the surgery, I walked a few steps. After a day, I got the catheter out and could urinate normally again. After two days, I was eating “SmartGel”, a food substitute that has mysteriously failed to catch on outside of the immobilized-hospital-patient market. After three, I was out of the hospital. After four, I started easing myself back into (remote) work. After a week, I flew cross-country. . . . and then I got the UTI. If this section sounds schizophrenic, it’s because it’s a compromise between an original draft where I said nothing went wrong and it was amazing, and a later draft written after a haze of bladder pain. Just don’t develop complications, that’s my advice. Still, I recently heard from the surgeon that my recipient’s side of the surgery was a success, that my kidney was in them and going fine - and that put things back into perspective. To a first approximation, compared to the inherent gravity of taking an organ out of one person and putting it in a second person and saving their life - it was all easy and everything went well. When I look back on this in a decade, I’ll remember it as everything being easy and going well. Even now, with some lingering bladder pain, modern medicine still feels like a miracle. VII. In polls, 25 - 50% of Americans say they would donate a kidney to a stranger in need. This sentence fascinates me because of the hanging “would”. Would, if what? A natural reading is “would if someone needs it”. But there are 100,000 strangers on the waiting list for kidney transplants. Between 5,000 and 40,000 people die each year for lack of sufficient kidneys to transplant. Someone definitely needs it. Yet only about 200 people (0.0001%) donate kidneys to strangers per year. Why the gap between 25-50% and 0.0001%? Some of you will suspect respondents are lying to look good. But these are anonymous surveys. Lying to themselves to feel good, then? Maybe. But I think about myself at age 20, a young philosophy major studying utilitarianism. If someone had asked me a hypothetical about whether I would donate a kidney to a stranger in need, I probably would have said yes. Then I would have continued going about my business, never thinking of it as a thing real-life people could do. Part of this would have been logistics. I wouldn’t have known where to start. Do you need to have special contacts in the surgery industry? Seek out a would-be recipient on your own? Where would you find them? But more of it would have been psychological: it just wasn’t something that the people I knew did, and it would be weird and alienating for me to be the only one. This is going to be the preachy “and you should donate too!” section you were dreading all along, but I’m not going to make a lot of positive arguments. If 90% of the people who answer yes on those surveys are lying to feel good, then only 3 - 5% really want to donate. But bringing the donation rate from 0.0001% of people to 3 - 5% of people would solve the kidney shortage many times over. The point isn’t to drag anti-donation-extremists kicking and screaming to the operating table. The point is to reach the people who already want to do it, and make them feel comfortable starting the process. 20-year-old me was in that category. The process of making him feel comfortable involved fifteen years of meeting people who already done it. During residency, I met a fellow student doctor who had donated. Later, I got involved in effective altruism, and learned that movement leader Alexander Berger - a guy who can easily direct millions of dollars at whatever cause he wants - had donated his personal kidney as well. Some online friends. Some people I met at conferences. And Dylan Matthews, who I kept crossing paths with (most recently at the Manifest journalism panel). After enough of these people, it no longer felt like something that nobody does, and then I felt like I had psychological permission to do it. (obviously saints can do good things without needing psychological permission first, but not everyone has to be in that category, and I found it easier to get the psychological permission than to self-modify into a saint6.) So I’m mostly not going to argue besides saying: this is a thing I did, it’s a thing hundreds of other people do each year, getting started is as simple as filling out a form, and if it works for you, you should go for it7. When I woke up in the recovery room after surgery, I felt great. Amazing. Content, peaceful, proud of myself. Mostly this was because I was on enough opioids to supply a San Francisco homeless encampment for a month. But probably some of it was also the warm glow of having made a difference or something. That could be you! VIII. The ten of you who will listen to this and donate are great. That brings the kidney shortage down from 40,000 to 39,990/year. Everyone knows we need a systemic solution, and everyone knows what that solution will eventually have to be: financial compensation for kidney donors. But so far they haven’t been able to get together enough of a coalition to overcome the usual cabal of evil bioethicists who thwart every medical advance. My kidney donation “mentor”8 Ned Brooks is starting a new push - the Coalition To Modify NOTA - which proposes a $100,000 refundable tax credit - $10,000 per year for 10 years - for kidney donors. There would be a waiting period and you’d have to get evaluated first, so junkies couldn’t walk in off the street and get $100K to spend on fentanyl. No intermediate company would “profit” off the transaction, and rich people wouldn’t be able to pay directly to jump in line. It would be the same kidney donation system we have now, except the donors get $100,000 back after saving the government $1MM+. (the libertarian in me would normally prefer a free market, but “avoid taxes by selling your organs” also has a certain libertarian appeal) This came up often when I talked to other donors. They all had various motivations, but one of the things they cared about was being able to advocate for these kinds of systemic changes more effectively. I personally have been wanting to push this in an essay here for a while, but it seemed hypocritical to play up the desperate kidney shortage while I still had two kidneys. Now I can support NOTA modification whole-heartedly . . . full-throatedly? . . . it’s weird how many of these adverbs involve claims to still have all of your organs. This is also one of the answers to the question I asked in section IV: how do you balance acts of heroic altruism that everyone will love you for vs. acts of boring autistic altruism that will make everyone hate you, but which will accomplish more good in the end?) Coalition To Modify NOTA is full of previous living kidney donors, who are using the moral clout and recognition they’ve gotten to get attention and change the system in an unglamorous way. I find this an admirable way of squaring the circle: do the flashy heroic things to gain social capital, then spend the social capital on whatever’s ultimately most important. If you get one takeaway from this, let it be that those guys who bought the castle were good guys. Two takeaways, and it’s that plus modify NOTA. Three takeaways, and you should feel permission to (if you want) donate a kidney. You can sign up here.9 Feel free to email me at scott@slatestarcodex.com if you have questions about the process. 1Further perspective: I’m 38, which gives me a 2/million total chance of dying per day. So the likelihood that I would die during my kidney operation equals the likelihood that I would die during a randomly chosen two months of everyday life. 2Maybe, kind of. Our knowledge of how radiation causes cancer comes primarily from Hiroshima and Nagasaki; we can follow survivors who were one mile, two miles, etc, from the center of the blast, calculate how much radiation exposure they sustained, and see how much cancer they got years later. But by the time we’re dealing with CAT scan levels of radiation, cancer levels are so close to background that it’s hard to adjust for possible confounders. So the first scientists to study the problem just drew a line through their high-radiation data points and extended it to the low radiation levels - ie if 1 Sievert caused one thousand extra cancers, probably 1 milli-Sievert would cause one extra cancer. This is called the Linear Dose No Threshold (LDNT) model, and has become a subject of intense and acrimonious debate. Some people think that at some very small dose, radiation stops being bad for you at all. Other people think maybe at low enough doses radiation is good for you - see this claim that the atomic bomb “elongated lifespan” in survivors far enough away from the blast. If this were true, CTs probably wouldn’t increase cancer risk at all. I didn’t consider myself knowledgeable enough to take a firm position, and I noticed eminent scientists on both sides, so I am using the more cautious estimate here. 3I told them I had an aunt who died of radiation-induced cancer. It’s true, but I feel grubby for bringing her into this; I thought doctors would be more likely to listen to an emotional story than cold logic. 4EAs have been debating the exact effectiveness of kidney donations for a long time. You can find good skeptical arguments by Jeff Kaufman and Derek Shiller, and good arguments in favor by Alexander Berger and Tom Ash. 5Outside of Philosophy 101 thought experiments, there’s a nonprofit that will often reimburse you for lost wages from your donation. 6Self-modifying into a person who can act boldly without social permission is a more general solution and has many other advantages. But the long version involves living a full life of accumulating moral wisdom, and the short version starts with removing guardrails that are there for good reasons. 7But here are some practical points you might not already appreciate: You shouldn’t have to pay much money. If, like me, you need to travel (eg to New York), kidney related charities will reimburse your travel costs (in theory, I haven’t yet proven this, and a few costs were illegible and I decided not to submit them).
Inline links: polls, 5,000, 40,000, Manifest journalism panel, 6, filling out a form, 7, usual, 8, the, here, 9, 1, 2, Linear Dose No Threshold, this claim, 3, 4, Jeff Kaufman, Derek Shiller, Alexander Berger, Tom Ash, 5, 6, 7
Philosophy Of Self-Awareness1 mentions across 1 issues

Philosophy Of Self-Awareness is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between September 19, 2022 and September 19, 2022. The archive places it in contexts such as "This sounds like a stupid example from a Philosophy Of Self-Awareness class". It most often appears alongside AskReddit, Conjecture, Dittomancy.

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Janus' GPT Wrangling
September 19, 2022 · Original source
But sometimes GPT-3 genuinely gets it right. The most common way for that to happen is (again) by mistake. A common failure mode is to repeat the same sentence several times. GPT-3 was trained on a corpus of Internet text, and some of the Internet text was discussions of GPT-2. Many of the samples it saw that repeated the same sentence over and over in an endless loop were discussions of GPT-2 doing this. So sometimes it will get stuck in a loop, then end with “This is an example of text produced by a transformer language model”. This sounds like a stupid example from a Philosophy Of Self-Awareness class, but sometimes it really happens. Here’s an example from one of Janus’ attempts to generate Loom documentation:
phlegm1 mentions across 1 issues

phlegm is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between April 09, 2021 and April 09, 2021. The archive places it in contexts such as "The Human body contains blood, phlegm, yellow bile and black bile". It most often appears alongside 1913 Nobel Prize in Physiology or Medicine, Alexandria, Aristotelian.

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phlegm
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Your Book Review: On The Natural Faculties
April 09, 2021 · Original source
Centuries went by, but not much changed. Charles Richet, winner of the 1913 Nobel Prize in Physiology or Medicine, said that Galen and “all the physicians who followed [him] during sixteen centuries, describe humours which they had never seen, and which no one will ever see, for they do not exist.” Some of the ‘humors’ exist, he says, like blood and bile. But of the “extraordinary phlegm or pituitary accretion” he says, “where is it? Who will ever see it? Who has ever seen it? What can we say of this fanciful classification of humours into four groups, of which two are absolutely imaginary?”
The Human body contains blood, phlegm, yellow bile and black bile. These are the things that make up its constitution and cause its pains and health. Health is primarily that state in which these constituent substances are in the correct proportion to each other, both in strength and quantity, and are well mixed. Pain occurs when one of the substances presents either a deficiency or an excess, or is separated in the body and not mixed with others.
Long-term trends towards any of the humors were responsible for what we would call personality. Hence the terms sanguine, phlegmatic, melancholy and so on for different personal traits and emotional conditions.
phlegmatic1 mentions across 1 issues

phlegmatic is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between April 09, 2021 and April 09, 2021. The archive places it in contexts such as "Hence the terms sanguine, phlegmatic, melancholy and so on for different personal traits"; "Hence the terms sanguine, phlegmatic, melancholy and so on for different personal traits and emotional conditions". It most often appears alongside 1913 Nobel Prize in Physiology or Medicine, Alexandria, Aristotelian.

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phlegmatic
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Your Book Review: On The Natural Faculties
April 09, 2021 · Original source
Long-term trends towards any of the humors were responsible for what we would call personality. Hence the terms sanguine, phlegmatic, melancholy and so on for different personal traits and emotional conditions.
phlogiston1 mentions across 1 issues

phlogiston is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between October 28, 2022 and October 28, 2022. The archive places it in contexts such as "We used to make fun of phlogiston". It most often appears alongside 15th century, Adam, Almighty God.

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phlogiston
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Book Review: Malleus Maleficarum
October 28, 2022 · Original source
Paging Arthur Miller… You can just buy the Malleus Maleficarum. So, why haven’t you? Might the witches’ spiritual successors be desperate to delegitimize the only thing they’re truly afraid of - the vibrant, time-tested witch hunting expertise of the Catholic Church? Summers writes: It is safe to say that the book is to-day scarcely known save by name. It has become a legend. Writer after writer, who had never turned the pages, felt himself at liberty to heap ridicule and abuse upon this venerable volume. . . He did not know very clearly what he meant, and the humbug trusted that nobody would stop to inquire. For the most part his confidence was respected; his word was taken. We must approach this great work - admirable in spite of its trifling blemishes - with open minds and grave intent; if we duly consider the world of confusion, of Bolshevism, of anarchy and licentiousness all around to-day, it should be an easy task for us to picture the difficulties, the hideous dangers with which Henry Kramer and James Sprenger were called to combat and to cope . . . As for myself, I do not hesitate to record my judgement . . . the Malleus Maleficarum is one of the most pregnant and most interesting books I know in the library of its kind. Big if true. I myself read the Malleus in search of a different type of wisdom. We think of witch hunts as a byword for irrationality, joking about strategies like “if she floats, she’s a witch; if she drowns, we’ll exonerate the corpse.” But this sort of snide superiority to the past has led us wrong before. We used to make fun of phlogiston, of “dormitive potencies”, of geocentric theory. All these are indeed false, but more sober historians have explained why each made sense at the time, replacing our caricatures of absurd irrationality with a picture of smart people genuinely trying their best in epistemically treacherous situations. Were the witch-hunters as bad as everyone says? Or are they in line for a similar exoneration? The Malleus is traditionally attributed to 15th century theologians/witch-hunters Henry Kramer and James Sprenger, but most modern scholars think Kramer wrote it alone, then added the more famous Sprenger as a co-author for a sales boost. The book has three parts. Part 1 is basically Summa Theologica, except all the questions are about witches. Part 2 is basically the DSM 5, except every condition is witchcraft. Part 3 is a manual for judges presiding over witch trials. We’ll go over each, then return to this question: why did a whole civilization spend three centuries killing thousands of people over a threat that didn’t exist? II: Thou Shalt Have Witches In Heaven Almost half the Malleus is devoted to purely philosophical questions surrounding witchcraft. Paramount among these: why would a perfectly just God allow witches to exist? The answer probably has something to with the Devil. And you can probably get part of the way by saying that God has a principled commitment to let the Devil meddle in human affairs until the End of Days. But then you get another issue: the Devil was once the brightest of angels. He’s really really powerful. Completely unrestrained, he can probably sink continents and stuff. So why does he futz around helping elderly women kill their neighbors’ cattle? Put a different way, there’s a very narrow band between “God restrains the Devil so much that witchcraft can’t exist” and “God restrains the Devil so little that witches have already taken over the world”. Prima facie, we wouldn’t expect the amount God restrains the Devil to fall into this little band. But in order to defend the existence of witchcraft, Kramer has to argue that it does. Did you know: the German name for Malleus Maleficarum is “Der Hexenhammer” His arguments ring hollow to modern ears, and honestly neither God nor the Devil comes out looking very good. God isn’t trying to maximize a 21st century utilitarian view of the Good, He’s trying to maximize His own glory. Allowing some evil helps with this, because then He can justly punish it (and being just is glorious) or mercifully forgive it (and being merciful is also glorious). But, if God let the Devil kill everyone in the world, then there would be no one left to praise God’s glory, plus people might falsely think God couldn’t have stopped the Devil if He’d wanted to. So the glory-maximizing option is to give the Devil some power, but not too much. Meanwhile, the Devil isn’t trying to maximize 21st century utilitarian evil. He’s trying to turn souls away from God. So although he could curse people directly, what he actually wants is for humans to sell their soul to him in exchange for curse powers. So whenever possible he prefers to act through witches. The rest of this part is just corollaries of these basic points. But there sure are a lot of corollaries, like: Question III: Whether Children Can Be Generated By Incubi And Succubi So, we all know that sometimes demons who look like hot men come and have sex with women in the middle of the night. But can these demons make a woman pregnant? It would seem that the answer should be no, because the Bible says God created Man in His own image, which suggests the conception of new humans is pretty holy, which makes it sound kind of blasphemous to suggest demons could do it. On the contrary side, we know that demons can have kids with humans. The Bible says so: Genesis 6 talks about nephilim, children of “the sons of God” by “the daughters of men”. And St. Augustine seems to think all those stories about Greek gods impregnating women were incubus demons. So “it is just as Catholic a view to hold that men may at times be begotten by means of incubi and succubi, as it is contrary to the words of the Saints and even to the tradition of Holy Scripture to maintain the opposite opinion.” Since the incubi cannot produce semen themselves, probably they steal it from some other human, then bring it to the womb of the person they are having sex with. Question VI: Concerning Witches Who Copulate With Devils - Why Is It That Women Are Chiefly Addicted To Evil Superstitions? Why are most witches women? Probably because women are awful: John Chrystotom says . . . what else is woman but a foe to friendship, an unescapable punishment, a necessary evil, a natural temptation, a desirable calamity, a domestic danger, a delectable detriment, an evil of nature, painted with fair colors! Therefore if it be a sin to divorce her when she ought to be kept, it is indeed a necessary torture, for either we commit adultery by divorcing her, or we must endure daily strife. In fact, the word for woman in Latin is femina, which can also have the form feminus, which is literally just fe minus (lesser in faith)! Because women are less faithful, more carnal, and mentally weaker, they are more easily tempted by the Devil, and make up the majority of witches. Question IX: Whether Witches May Work Some Prestidigitory Illusion So That The Male Organ Appears To Be Entirely Removed And Separate From The Body. IE: can witches steal your penis? It would seem that witches can steal your penis. After all, many people claim to have had their penis stolen by witches. The fifteenth-century peasants among whom Kramer went witch-hunting claimed this. And modern people claim it even today. Frank Bures’ The Geography Of Madness is a great book about recent penis-stealing-witch-related panics, which happened until the mid-20th century in Asia and still happen in Africa. For some reason, this is a classic concern across cultures and centuries. But on the contrary side, God created the human body, and charged Man to be fruitful and multiply. So if the Devil could steal people’s penises it would seem that he must be more powerful than God, which is blasphemous. Kramer answers that witches cannot steal men’s penises, but they can cast an illusion that causes it to look and feel like the penis has been stolen. Classic namby-pamby liberal centrist compromise! Question XIV: The Enormity Of Witches Is Considered, And It Is Shown That The Whole Matter Should Be Rightly Set Forth And Declared This is is one of those “more a comment than a question” questions. Kramer suggests that not only is witchcraft a sin, but it is the worst sin. This section (plus the next few) is a list of all the different things witches are worse than, and why. Witches are worse than pagans, because pagans never knew about Christianity. But witches know about it and deliberately reject it. Witches are worse than Jews, because Jews never claimed to be Christian. But witches were once Christian and then renounced the faith. Witches are worse than ordinary heretics, because ordinary heretics only reject some parts of the faith. But witches implicitly reject all of it by supporting the Devil himself. Witches are worse than Adam, because although Adam’s sin had terrible consequences for the human race, this wasn’t really his direct decision. If we limit our consideration to the specific act, Adam just disobeyed God once, but witches are disobeying God all the time. In fact witches are more sinful than the Devil himself (!), and the Devil’s sin “is in many respects small in comparison with the crimes of witches”. For “both sin against God; but [the Devil] against a commanding God, and [witches] against One who dies for us, Whom, as we have said, wicked witches offend above all.” Witches are literally the worst thing in the entire universe. Whatever else you are concerned about, there is no way it is anywhere close to as bad as witches. If you had the faintest idea how bad witches really were, you would be freaking out all the time. You need to stop whatever you were doing before and become some kind of witch-minimizer instead. This ends Part 1, but if you’re interested you might want to look at further questions from this section, including What Is The Source Of The Increase Of Works Of Witchcraft? Whence Comes It That The Practice Of Witchcraft Hath So Notably Increased?
Inline links: https://substackcdn.com/image/fetch/$s_!BmDQ!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F0d8cbda2-8ffa-4d5a-9929-81981494f499_720x960.jpeg, The Geography Of Madness, need to, What Is The Source Of The Increase Of Works Of Witchcraft? Whence Comes It That The Practice Of Witchcraft Hath So Notably Increased?
phlox1 mentions across 1 issues

phlox is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between February 24, 2021 and February 24, 2021. The archive places it in contexts such as "Declassed also are phlox". It most often appears alongside 1950s, 1980s, 1983.

Reference entry
phlox
Mention count
1
Issue count
1
First seen
February 24, 2021
Last seen
February 24, 2021
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Book Review: Fussell On Class
February 24, 2021 · Original source
Anyone imagining that just any sort of flowers can be presented in the front of a house without status jeopardy would be wrong. Upper-middle-class flowers are rhododendrons, tiger lilies, amaryllis, columbine, clematis, and roses, except for bright-red ones. One way to learn which flowers are vulgar is to notice the varieties favored on Sunday-morning TV religious programs like Rex Humbard's or Robert Schuller's. There you will see primarily geraniums (red are lower than pink), poinsettias, and chrysanthemums, and you will know instantly, without even attending to the quality of the discourse, that you are looking at a high-prole setup. Other prole flowers include anything too vividly red, like red tulips. Declassed also are phlox, zinnias, salvia, gladioli, begonias, dahlias, fuchsias, and petunias. Members of the middle class will sometimes hope to mitigate the vulgarity of bright-red flowers by planting them in a rotting wheelbarrow or rowboat displayed on the front lawn, but seldom with success.
Phoenicians1 mentions across 1 issues

Phoenicians is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between March 03, 2023 and March 03, 2023. The archive places it in contexts such as "the paper finds lead levels started rising 1000 BC, which it links to the Phoenician expansion". It most often appears alongside 1700s Great Britain, Acropolis of Athens, Against The Grain.

Reference entry
Phoenicians
Mention count
1
Issue count
1
First seen
March 03, 2023
Last seen
March 03, 2023
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Against Ice Age Civilizations
March 03, 2023 · Original source
In theory, this could suggest that no ancient civilization reached a tech level where it started mining lead, ie the tech level the Phoenicians had in 1000 BC. This is in theory only, because I can’t find a clear record of anyone checking. I assume ice core scientists would have noticed if it happened, but there’s no publicly available dataset with lead levels 10,000 years before present, nor is there a paper titled “We Checked To See If There Were Anthropogenic Lead Emissions In 10,000 BC And There Definitely Weren’t”. Here is a paper that looks at lead level in human bones. They don’t do a great job explaining how lead makes it into human bones, but it seems like a mix of the kind of lead pollution that makes it to Greenland ice cores, plus personally wearing or consuming things that have touched lead. This study investigates skeletons from 12,000 BC onwards, and finds that lead levels start rising in 5,000 BC, when people developed “cupellation”, a technique for using lead to purify gold and silver (it then goes up much further between 1000 - 500 BC, probably the same spike the Greenland cores found). So this presents some very weak evidence against significantly elevated lead from 12,000 BC onward. But it doesn’t rule out small amounts of lead mining far away from the bones’ previous owners, and doesn’t rule out a civilization lasting from 15,000 - 13,000 BC. A Great Britain-level civilization would be expected to raise lead levels a lot, and this pretty strongly rules it out. I would expect an Egypt-level civilization to at least invent cupellation, but I don’t know if its lead would necessarily make it to wherever these bones came from. A Stonehenge or Gobekli Tepe level civilization isn’t ruled out at all. Conclusion I think there’s pretty strong evidence against lost Egypt- or Great Britain- level Ice Age civilizations. I don’t want to rule out a lost Stonehenge or Gobekli Tepe level civilization, but there’s not much positive evidence, and there’s some negative evidence. Stonehenge was built by Neolithic farmer-pastoralists, who had lots of domesticated crops and animals. Gobekli Tepe was built right next to the area where wheat was domesticated at around the same time. Existing early monuments mostly suggest a story where sedentary city- and temple- building civilizations either require domesticated agriculture, or invent it very quickly. None of this means Ice Age people didn’t have fascinating cultures of their own which were advanced in other ways - interesting laws, taboos, mythologies, customs, oral traditions. Tyler Cowen says that everything started earlier than you think, and this is what we’ve been finding about various forms of human culture too (cf. Against The Grain, The Dawn Of Everything). I just don’t expect lost Ice Age cities or giant monuments. I think Michael Shermer’s attempt to argue the same case is weak, relies on a still-controversial rejection of the Younger Dryas Impact Hypothesis, and generally leans too much on the absurdity heuristic without moving the needle one way or the other. All of the following predictions are about structures on Earth built by homo sapiens without time travel: 20% chance we ever find something demonstrating equal or greater architectural advancement to Gobekli Tepe, dating from before 11,000 BC.
Inline links: Here is a paper, https://substackcdn.com/image/fetch/$s_!SS8H!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F0b5de41a-38d8-4145-821d-5e2f6d2de228_534x215.png, Against The Grain, The Dawn Of Everything, Michael Shermer’s attempt to argue the same case, Younger Dryas Impact Hypothesis
Phoenix Wright1 mentions across 1 issues

Phoenix Wright is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between July 26, 2024 and July 26, 2024. The archive places it in contexts such as "Trials work a lot like Phoenix Wright". It most often appears alongside 1600 Pennsylvania Avenue, 2020 election, 2024 book review contest.

Reference entry
Phoenix Wright
Mention count
1
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1
First seen
July 26, 2024
Last seen
July 26, 2024
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Your Book Review: Real Raw News
July 26, 2024 · Original source
Making the sentence for all crimes identical: Mandatory death penalty9. As far as perfidious methods to deliberately destroy due process and engineer mass executions go, the Law of 22 Prairial is pretty much unmatched in human history. And yet: In the roughly two months of the law’s existence, about one-fifth of defendants were still acquitted! No such good fortune exists in Gitmo. The White Hats’ secret tribunal is a tribunal of blood. In three years of activity, as far as I know exactly one person has escaped conviction: Former Attorney General Jeff Sessions, freed after a direct intervention from Trump. A tiny handful of others have received decades-long prison sentences, but even they tend to meet bad ends. Bill Clinton received a life sentence, only to mysteriously die in prison, perhaps murdered by his daughter Chelsea, who wasn’t really his daughter, but nevertheless soon wound up executed herself. Not only does the rate of death sentences at Gitmo seem to exceed 90 percent, Baxter makes very little effort to portray the proceedings as fair or just. Upon arrest, instead of being read their rights, detainees are informed that they have no rights, and are instead “enemy combatants.” Yet despite being classified as “enemy combatants,” defendants are almost without exception charged with treason. The U.S. Constitution defines treason narrowly as levying war against the United States, or giving aid and comfort to its enemies, and requires at least two witnesses to the same specific act, but in Gitmo the label is invoked with a liberality that would make Robespierre blush. “Traitors” have been arrested and convicted for telling troops not to attend Trump rallies and for ruling against Donald Trump in court. Defense attorneys are denied access to evidence pre-trial, and many defendants get no lawyers at all. Trials work a lot like Phoenix Wright, in that at any point the three-officer panel10 can simply declare they’ve seen enough evidence and pronounce a conviction with death sentence immediately. In the case of former Tom Hanks co-star, this has happened within five minutes. Appeals are non-existent. The actual executions sometimes involve tormenting the condemned with fake escape attempts or pardons: The driver told Whitmer he needed to make a pitstop to grab her “exoneration paperwork.” Then Whitmer saw the clearing and the gallows and Vice Adm. Crandall. And the hangman and a Navy chaplain standing atop the gallows. “You lied to me,” Whitmer bellowed. “Minor error, not a lie,” the driver replied. […] The admiral instructed the hangman to flip the switch, and a second later, Whitmer was swinging from the rope, a guttural gurgling sound escaping her lips. She was officially pronounced dead several minutes later. “Another Covid queen out of the way,” Adm. Crandall said. During the treason trial of Hillary Clinton crucial evidence is provided by former campaign manager John Podesta, who accepts a plea deal for life in prison in return for testifying about Clinton’s child-trafficking activities. But after Clinton had safely been hanged, the military tribunal simply decided to revoke Podesta’s plea deal because, well, they felt like it. “Even though he’s not prosecuting Podesta’s case, Vice Adm. John G. Hannink made the decision to renege on the deal. He’s the one who offered it. The severity of Podesta’s crimes matched Clinton’s—a lot of stuff they did in tandem, together. When you think about it, there’s really no reason why he should get special treatment. He’s a sodomist [sic.]11. Before breaking the deal, he called Trump,” our source said. But Trump, our source noted, recused himself from the decision-making process, as he didn’t want his personal feelings of the defendant to interfere with military justice. […] “If the court wants him to hang, let him hang,” Trump reportedly said. As it happens, John Podesta was actually executed by firing squad. But hey, at least he got a trial. Sometimes, particularly evil members of the Deep State are simply beaten to death in their cells, or thrown overboard. The figure of Vladimir Putin is also a vessel for fans’ darker desires. Trump and his American allies, being properly heroic, at least take down their foes gradually. Putin’s Russians, on the other hand, live up to movie stereotypes. The Army … pulled the condemned from their cells 25 at a time, binding the criminals to logs staked in the ground and blindfolding them. They had received no trials, last meals, Last Rites, or final words. A firing squad taught them the consequences of vaccine adherence. The Army didn’t bother removing the corpses before lining up the next 25; they simply let the dead bodies flop to the ground and forced the next group to witness the ineluctable fate awaiting them, the outcome of their insouciance12. What to make of all this? Honestly, I’m not entirely sure, and the takeaway might simply be “Michael Baxter needs to mix it up to keep the site interesting.” It might also speak to the bewildering complexity of modern life and the desire for something simpler and more cinematic. As people sometimes complain, Nothing Ever Happens. But on RRN, the Happening is relentless and constant. The normal legal system is aggravatingly glacial, taking years to resolve cases and often imposing meager sentences when a case finally concludes. Most of one’s political enemies, even if they lose an election, simply lateral to a high-paying private sector job or at worst fade into obscurity. But in a real, raw legal system, evil is sniffed out with much greater alacrity; the bad people are so obvious and their crimes so glaring that they can be taken out extrajudicially with no worry about a miscarriage of justice. The apparently-complex conspiracy cinematic universes is actually appealing because it makes the world far, far simpler. The bad people are all maximally bad, deserving of hastily-dispensed maximum justice. Some of this is worrisome, too: If thousands of relatively ordinary people are willing to believe in ad-hoc military tribunals executing people with minimal due process for crimes like “ruling against Donald Trump in court,” that could be a sign that modern constitutional society is a more superficial veneer than one would hope. The World’s Laziest Conspiracy One of the most striking things about both Real Raw News and the Qanon movement it spun off from is that in some ways they are un-conspiracies. Your more traditional conspiracy, about the Rothschilds or the World Economic Forum or the Lizard People, tells you that normal political engagement is pointless, as all that really matters is confronting and defeating the hidden forces manipulating or controlling events. But RRN is a conspiracy theory that calls for total inaction. RRN believers don’t need to raise money or write letters to the editor or join political activism groups or even vote. The only thing expected of an adherent is to “trust the plan.” They aren’t even waiting for a promised future deliverance. Deliverance is, in fact, happening right now – merely off-screen. It’s actually funny to me that the (official) press freaks out so much about Qanon, and its potential to inspire violence. Qanon and RRN tell the public that whatever has them down and depressed shouldn’t, because it’s all fake, and there are unseen heroes protecting them in the shadows. Don’t worry, just have faith and know things will work out. Real Raw News is the opiate of the digital masses. Real Raw News is the exact sort of conspiracy theory that the Deep State, if it exists, should want to exist and be popular. It’s the sort of conspiracy that the Deep State, if it exists, might deliberately invent. Do I think that’s what happened here? Not at all – Real Raw News is way too much work for a government employee. Trump Will Never Die But what about five years from now? What if there were some technological change that would make it far, far easier to produce evidence of a sweeping conspiracy theory? That’s right, this review is actually about AI13. The rise of realistic artificial intelligence has created a lot of fretting about deepfakes, and it’s also created a lot of fretting about porn. Will young men really bother with the pain and difficulty and awkwardness of dating in real life, when they can just create a custom AI girlfriend to their exact specifications, then simulate sex with her using virtual reality? Will women bother with seeking out a boyfriend if they can use an LLM to give them perfect 24/7 empathy and emotional validation? Questions of sex and relationships are converging on Robert Nozick’s experience machine – will people still seek the real thing if artificial substitutes are increasingly realistic as alternatives? But for some reason, nobody is asking this about the news. Oh, sure, people have fretted that a deepfake video might smear a person’s reputation or swing an election. But as the AI revolution continues, a lot more becomes possible. Remember in 2022, when a homeless guy broke into Nancy Pelosi’s home and attacked her husband with a hammer? For a while, conspiracies flourished that Paul Pelosi was actually having some kind of erotic tryst with his attacker, and that police body camera footage might confirm this. The footage came out and, of course, offered no evidence of this. But now imagine a world where, on Twitter, an anonymous source claims that they have the real body camera footage, and it does show that Paul Pelosi was having a lovers’ quarrel with his attacker. The other, mundane footage is a deepfake, released by police to cover things up, or invented from scratch by the press or the Democratic Party or both working together. In this world, how many people end up believing fabricated proof of Paul Pelosi’s gay lover? And before you dismiss this as all totally ridiculous, remember that lots of people believed this story with no evidence at all. Many thousands of people have deluded themselves into thinking that Real Raw News is true simply because they badly want it to be true. It indulges their personal political beliefs, affirms the just-world fallacy, and lets them feel as though they possess “secret” knowledge of the world, simply by reading a blog nobody else takes seriously. But in a sense, all of us have a little of the Real Raw News believer in us. We’re prone to confirmation bias – we like reading stories and studies that confirm our pre-held beliefs, and we’re more likely to avoid or ignore those that don’t. Sometimes, we get too excited and fall for stories that are misleading, or out of context, or dishonestly presented. Sometimes, we have radically different interpretations of the same event caught on camera. Even if we know the world isn’t fair, we relish stories that let us pretend otherwise. So…how are those biases going to work when anyone can quickly create hyper-realistic looking “proof” for any story? Already, AI-fabricated images and videos are enough to bamboozle your mom on Facebook. Soon, they might be realistic enough to fool everybody without special training, and eventually they might be so realistic they can fool just about anyone. Right now, Real Raw News is a simplistic WordPress site that uses stock photos for its imagery. But with us approaching a future where intelligence itself is too cheap to meter, we may not be far from a world where every story, however preposterous, can have a convincing 4k video of it happening. Donald Trump can be president forever, with all the evidence one could ever want. Every day of Hillary Clinton’s military tribunal will have a full day of court footage, plus a condensed highlight reel for the people who want to skip boring legal procedure. Every Marine/FEMA battle in Maui will have authentic-looking combat footage. Every Gitmo execution will be proven through “leaked” bootleg recordings of gallows and firing squads. Imagine you are an ordinary, mildly engaged American citizen. You live far from the halls of power, you work an ordinary job, and whatever your feelings on political issues, you rarely see elections translate in a clear way to your own daily life. You might be interested in Washington, but Washington really isn’t that interested in you. Online, the world throws a million potential narratives at you. In some of them, the world is a confusing mess of moral gray areas. In others, the people you care about are winning. But in some narratives, you’re the hero, the people you like do good things, and the bad guys get what they deserve. The superficial evidence for all of these narratives is about equally convincing, at a glance. Look outside, and it’s hard to see the impact of any of the stories. Your entire understanding of reality is mediated through what sites you choose to read and what videos you choose to watch. As a politically marginal person, it won’t matter what you as an individual choose to believe. So, what happens if you choose to believe the story you find most enjoyable? And what if millions of others choose the same? 1 “Wait a minute, this is about a fake news website? Why is it in this contest?” Excellent question! To that, I offer several answers: A collection of fake news blog posts may as well be considered a long-running series of short stories, and I hope that we’d be allowed to review the collected short stories of an author even if they were never technically compiled into a book.
Inline links: 9, Jeff Sessions, received a life sentence, die in prison, executed herself, telling troops not to attend Trump rallies, ruling against Donald Trump in court, 10, within five minutes., tormenting, 11, firing squad, thrown overboard, 12, Nothing Ever Happens, 13, experience machine, 1
Phosphorus1 mentions across 1 issues

Phosphorus is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between August 23, 2024 and August 23, 2024. The archive places it in contexts such as "With eyes as bright as Phosphorus". It most often appears alongside A Few Don’ts by an Imagiste, A Hymn to God the Father, Alabama.

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Phosphorus
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1
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1
First seen
August 23, 2024
Last seen
August 23, 2024
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Your Book Review: The Complete Rhyming Dictionary and Poet's Craft Book (1936 Edition)
August 23, 2024 · Original source
A maiden from the Bosphorus With eyes as bright as Phosphorus Once wed the wealthy bailiff Of the caliph Of Kelat.
Photinaioi1 mentions across 1 issues

Photinaioi is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between September 19, 2023 and September 19, 2023. The archive places it in contexts such as "the nations of ... Photinaioi". It most often appears alongside 15th century Sicilian manuscript, Agrimardio, Aigeis.

Reference entry
Photinaioi
Mention count
1
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1
First seen
September 19, 2023
Last seen
September 19, 2023
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Book Review: The Alexander Romance
September 19, 2023 · Original source
In case you’re wondering, in addition to Gog and Magog, this saved us from the nations of “Anougeis, Aigeis, Exenach, Diphar, Photinaioi, Pharizaioi, Zarmatianoi, Chachonioio, Agrimardio, Anouphagoi, Tharbaioi, Alans, Physolonikaioi, Saltarioi, and the rest.” I recognize two of these: the Sarmatians and the Alans - as real steppe tribes. The others are probably imaginary steppe tribes meant to represent how big and scary the steppe was in the Mediterranean imagination.
photoelectric effect1 mentions across 1 issues

photoelectric effect is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between June 03, 2021 and June 03, 2021. The archive places it in contexts such as "Einstein’s annus mirabilis, when he published papers on the photoelectric effect". It most often appears alongside ancient Rome, Asia, Becatti 1968.

Reference entry
photoelectric effect
Mention count
1
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1
First seen
June 03, 2021
Last seen
June 03, 2021
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Your Book Review: The Collapse Of Complex Societies
June 03, 2021 · Original source
When a field is established, you can get a lot done by making relatively obvious inferences and running cheap tests. (I’m not sure what share of the patents in the above graph were physics-related but it seems notable that 1905 was Einstein’s annus mirabilis, when he published papers on the photoelectric effect, Brownian motion, and special relativity). After that, you reach the questions you can only resolve by smashing particles into each other in a 10-kilometer long tube, or by buying millions of dollars’ worth of GPUs so you can check how much better neural networks do if you just let them have a billion parameters.
photonic tensor cores1 mentions across 1 issues

photonic tensor cores is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between July 27, 2021 and July 27, 2021. The archive places it in contexts such as "fascinating about photonic tensor cores". It most often appears alongside Britain, China, coronavirus.

Reference entry
photonic tensor cores
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1
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1
First seen
July 27, 2021
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July 27, 2021
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  • 26 July 27, 2021
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26
July 27, 2021 · Original source
Analytical Storytellers will be able to pitch the tone and content of their essays to a smart but not stuffy audience. Essays will connect with readers who possess the relevant subject-matter expertise, while also appealing to a layperson who is open-minded, but may not yet understand what’s so fascinating about Kessler syndrome or photonic tensor cores. After reading, however, they will.
Inline links: Kessler syndrome, photonic tensor cores
photoreceptors1 mentions across 1 issues

photoreceptors is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between June 10, 2025 and June 10, 2025. The archive places it in contexts such as "rhodopsin-based photoreceptors in my eye". It most often appears alongside brain, Chalmers, conscious.

Reference entry
photoreceptors
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1
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1
First seen
June 10, 2025
Last seen
June 10, 2025
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P-Zombies Would Report Qualia
June 10, 2025 · Original source
They wouldn’t answer “The light triggered the rhodopsin-based photoreceptors in my eye, the signal was transmitted to my brain, and it eventually reached the speech centers and made them say the word ‘red’”. After all, we hypothesized that the p-zombies don’t know anything humans don’t know, and most humans don’t know what “rhodopsin” is. In fact, we can imagine a primitive tribe of p-zombies who don’t know any biology - they don’t even know what the brain is - but who still have to be able to answer this question. Although these words are a correct description of what’s happening to the p-zombies neurologically (just as they would be a correct description of regular humans), there has to be some other answer about what they would tell us when we asked.
phthalates1 mentions across 1 issues

phthalates is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between January 09, 2025 and January 09, 2025. The archive places it in contexts such as "environmental groups and industry groups fought each other to a bloody standstill". It most often appears alongside Afghanistan, America, Brad Little.

Reference entry
phthalates
Mention count
1
Issue count
1
First seen
January 09, 2025
Last seen
January 09, 2025
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Bureaucracy Isn't Measured In Bureaucrats
January 09, 2025 · Original source
That’s worse! A few years ago, I debated Kevin Drum about (what I considered) a particularly egregious case where the FDA dragged its feet approving a life-saving medication. Drum argued that the FDA had behaved well. In support, he found some quotes from the doctor working on the medication, who praised all the FDA bureaucrats she had interacted with, calling them extremely helpful. This bothered me for a while, until I realized that of course it was true. In the model above, each bureaucrat processes ten forms. If the bureaucrats are benevolent, this might look like talking to the doctors, walking them through the process of figuring out their ten forms, and doing the work to add their ten forms to the FDA’s growing pile of evidence supporting the application. All of this co-exists comfortably with the insight that making doctors fill out a thousand forms before they can use a medication is an impediment to medical progress. This really sunk in for me when I read an article about the fall of Afghanistan to the Taliban in 2021. Many Afghans had collaborated with the Americans, eg as translators, in exchange for a promise of US citizenship. As the Taliban advanced, they called in the promise, begging to be allowed to flee to America before they got punished as traitors. The article focused on a heroic effort by certain immigration bureaucrats, who worked around the clock with minimal sleep for the last few weeks before Kabul fell, trying to get the citizenship forms filled in and approved for as many translators as possible. It made an impression on me because nobody was opposed to the translators getting citizenship, and the bureaucrats were themselves the people in charge of approving citizenship applications, so what exactly was forcing them to go to such desperate lengths? If you ponder this question long enough, you become enlightened about the nature of the administrative state. If you don’t, you end up like Ramaswamy, who seems to think that halving the number of bureaucrats will halve the number of forms that need to be filled out. I think in his worldview, the FDA will think “Now that we have fewer bureaucrats, it would take forever to complete our current process, so let’s simplify the process.” Maybe he is working off a thesis where red tape expands to consume the resources available to it (as measured in bureaucrats). But my impression is that the amount of red tape is determined more by things like: — How likely is it that their decision will get challenged in court? And if it gets challenged in court, what amount of paperwork do they have to show the judge to prove that they made the decision on a “reasonable basis”? For example, when I type “FDA sued” into Google, the top result is a news story from a few days ago, saying that an environmental organization sued the FDA for not listening to their earlier request to ban phthalates from food. Six years ago, the environmental groups submitted a petition (the catchily-named “Food Additive Petition 6B4815”) demanding that the FDA ban 28 phthalates. Two years ago, after consulting with industry, the FDA finally banned 23 phthalates but said that the other five were okay, releasing a 58 page decision explaining its decision. Two days ago, the environmental groups sued, saying the remaining 5 phthalates are still bad. I assume the lawsuit will nitpick the details of the the 58 page decision, trying to prove that it it didn’t violate any of hundreds of federal laws saying that bureaucratic decisions must be reasonable, bureaucratic decisions must be based on science, bureaucratic decisions must respond to the petitioners’ complaints, bureaucratic decisions cannot have disparate impacts on different races, etc. I also assume that if the FDA had banned all the phthalates, they would have faced an equally serious lawsuit from Big Phthalate saying they were unfairly crippling business. Why does it take six years to respond to a petition? My guess is because they knew they would get sued and so they have some sort of million-step process that addresses every single thing you can sue over, so that they can prove to the court that their process addresses all possible complaints and they followed it to the letter. If you cut their bureaucrats in half, that doesn’t mean there will be fewer steps in the process. It means they’ll keep wanting not to get sued, the process will stay the same, and everything will take twice as long. — What has Congress mandated that they do? For example, when I Google “Congressional FDA mandate”, I get a page on HR 7248, a bill currently making its way through Congress, which says: This bill requires the Food and Drug Administration (FDA) to establish a process that supports nonclinical testing methods for drug development that do not involve the use of animals. Specifically, the FDA must establish a pathway by which entities may apply to have nonclinical testing methods approved for use in a particular context. Qualifying methods must be intended to replace or reduce animal testing and to either improve the safety and efficacy of nonclinical testing or reduce the time to develop a drug. The FDA must issue its decision within 180 days of receiving an application. The FDA must also prioritize the review of applications for drugs that are developed using an approved nonclinical testing method. The FDA must annually post a report on its website that summarizes the results of the bill's implementation, including the number of applications received, types of methods that were approved, and the estimated number of animals saved as result of these methods. So the FDA has to establish this process and post an annual report on its website. How many bureaucrats per year does this take? Maybe five? If you halve the number of people at the FDA, you still need a constant five bureaucrats to comply with this particular law. If the bill passes, the FDA comes up with a nonclinical testing process, and someone (eg the nonclinical testing industry) doesn’t think it’s good enough, they can sue the FDA for not following the law. How good a nonclinical testing process will the FDA need in order to avoid lawsuits under this bill? I assume there is a large body of administrative law answering that question, and that it will take many bureaucrats to figure this out. Finally, I admit I’m a bit confused by this. IIRC “nonclinical testing” refers to things like testing drugs on stem cells or artificial organs instead of humans. You can obviously do this for some parts of the drug testing process, but not others; the FDA has already adjusted for this and integrated it into their guidelines to some extent. I can’t tell whether this law is a righteous attempt to correct bureaucratic foot-dragging, or a powergrab by Big Nonclinical Testing demanding that the FDA privilege their products over other forms of experiment. If the latter, the FDA may try to come up with some fake pathway that satisfies the letter of the law without really giving Big Nonclinical Testing any unfair privileges, and Big Nonclinical Testing will probably sue and say it violates this bill. How many bureaucrats do you think it will take to manage that? — How much will they get yelled at if they take too long to approve drugs, vs. if they mistakenly approve a bad drug? This is the basic determinant of all FDA drug approvals. Halving the number of FDA bureaucrats wouldn’t have literally zero effect on this balance. It would mean that approving new drugs would be delayed twice as long. This would be a little more outrageous than the current delay, and might shift an outrage-minimizing FDA director slightly in the direction of cutting rules. But solve for the equilibrium: there would still be more delay than there is now. Also, I don’t think public outrage about long drug delays is linear with regard to delay, and public outrage at bad drugs is constant and large. So I think at best, firing bureaucrats would shift this balance a small amount, and only by making everything overall worse. II. One possible objection: this assumes that the average bureaucracy is like the FDA drug approval process. But the FDA drug approval process’ job is to approve things. Maybe the average bureaucracy’s job is to ban things. Then decreasing their capacity would be good. (Vivek gets to be main example here because he tweeted, but the same considerations apply to Elon: even though the government as a whole is delaying SpaceX rocket launches, individual bureaucrats might be speeding them up through the same 1000-forms logic as in the FDA case) There’s certainly a spectrum from the most approval-focused bureaucracies to the most ban-focused bureaucracies. Thinking hard about this spectrum would be a step up from “instantly” firing 50% of all bureaucrats based on social security number. So maybe a steelman of Vivek’s point would be to fire 50% of people in the ban-focused bureaucracies (and maybe double the number of people in the approval-focused ones?) I’m still skeptical that this is how it works. The past few years have seen the cryptocurrency industry demand regulation, and the government mostly fail to step up (though crypto businesses hope the Trump administration will do better). Why do crypto businesses want to be regulated more? Because the alternative is something where it’s not clear what’s legal and anyone could be sued or shut down at any time. The chief legal officer of Coinbase, from the second link: All of us are begging for sensible standards that would allow us to get back to building great products and services and spend less time and frankly, less money, arguing over legal definitions and statutes. This isn’t because anyone specifically banned crypto. It’s because there are bans on other things (like unlicensed securities, money laundering, etc) that crypto is vaguely related to, sometimes an agency regulating these things will tell a crypto company “sorry, we think you’re illegal”, and crypto wants some specific list of things it can follow that explicitly establish it as on the right side of money-laundering and security-licensing laws. Obviously industries would prefer that these be simple and easy standards (“oh, don’t worry, you don’t have to worry about money laundering if you’re a crypto company”), but they would settle for strict regulations as long as the regulations carve out some ability for them exist at all. I’ve seen the same thing play out in another area I follow, cultured meat. There are many laws about what meat you can and cannot sell, how the animals have to be treated, what the sanitation standards are, et cetera. Some of these standards make no sense when applied to cultured meat; others, cultured meat naturally fails by default (you can’t prove you’re treating the animals in a certain way because there are no animals). Others are novel philosophical questions (can you sell cultured meat without saying it’s cultured? How big does the print need to be before it counts as saying that it’s cultured? What about on restaurant menus?) Situations like these mean that there’s no clear distinction between default-yes and default-no bureaucracies. There’s no explicit ban on crypto or cultured meat. But if you cripple bureaucracies’ ability to interact with these fields, it doesn’t mean they’re fully legal, free, and happy forever. It means they’re stuck in regulatory limbo. III. So it seems like you don’t want to fire bureaucrats, you want to cut red tape. In our toy model, you want to reduce the number of forms from 1,000 to (let’s say) 100. Then the same number of bureaucrats can get drugs approved ten times faster. In our non-toy actual model of what’s going on, this would require changing incentives. Maybe you could change judicial procedures so that fewer people sue, or the FDA needs less evidence to win any given lawsuit. This sounds hard (Vivek and Elon seem more qualified to wield chainsaws than to understand legal minutiae), possibly illegal (does the administrative branch even control how judicial procedure works?), and politically unpopular (this basically looks like telling people “f@#k you, companies can put as many phthalates as they want in food, we don’t have to prove that this decision is evidence based, and you’re not allowed to challenge us.”) Or it would require Congress to repeal legislation mandating things. These Congressional mandates are probably things that Congressmen and their constituents (either real constituents or special interests) care a lot about, so good luck getting them repealed. Also, doesn’t Congress pass like one bill per year now? This would normally make me pessimistic, but Vivek and other anti-bureaucracy activists have pointed to a recent success story: Idaho. Idaho cut their regulatory code by 38% in 2019, and since then it’s only gone down. How did they decrease red tape so fast? They did it through the power of nominative determinism. In that year, they elected a governor named Brad Little. His administration is called the Little Administration. Obviously government had to get smaller. But on a purely exoteric level, what methods did they use to pull this off? This CPAC article gives the basic story: The Little administration instituted sunset provisions that review each regulation every five years and make sure it’s justifiable.
Inline links: I debated Kevin Drum, a news story from a few days ago, a 58 page decision, have seen the cryptocurrency industry demand regulation, hope, https://substackcdn.com/image/fetch/$s_!TTSy!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fb73cf3f3-e501-49b6-b2a3-b84c602d5038_481x344.webp, This CPAC article
Are the most burdensome federal regulations more like the pharmacy door, where nobody can remember why they exist? Or are they more like phthalates, where environmental groups and industry groups fought each other to a bloody standstill, and any attempt to change anything will be met with lawsuits?
physics1 mentions across 1 issues

physics is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between December 05, 2024 and December 05, 2024. The archive places it in contexts such as "Taste Is Like Physics". It most often appears alongside @dieworkwear, AI Art Turing Test, Bauhaus.

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physics
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1
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December 05, 2024
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December 05, 2024
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Friendly And Hostile Analogies For Taste
December 05, 2024 · Original source
A. Taste Is Like Physics
Okay, fine, maybe it is an objective good determined by God. Just as non-physicists may have plausible but false folk theories of physics (“atoms are like little billiard balls, right?”) but real physicists know better, so rubes may have bad taste, but professional artists know what is actually tasteful.
This one would be pretty mysterious - we know physics is referring to the real nature of matter and energy and so on, but what is taste referring to?
physics Nobels1 mentions across 1 issues

physics Nobels is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between January 09, 2026 and January 09, 2026. The archive places it in contexts such as "we finally eliminate the ‘bro culture’ that prevents women from winning exactly 50% of physics Nobels". It most often appears alongside Alexa, bro culture, Choo Choo Train.

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physics Nobels
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January 09, 2026
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January 09, 2026
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The Permanent Emergency
January 09, 2026 · Original source
(This has also informed my opinion on all those blog posts where people say it’s the fault of the Feminized Longhouse Matriarchy that girls outperform boys in elementary school. I now think we’ll discover their long-sought ‘boy-friendly teaching methods’ around the same time we finally eliminate the ‘bro culture’ that prevents women from winning exactly 50% of physics Nobels.)
Phöbus1 mentions across 1 issues

Phöbus is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between November 07, 2023 and November 07, 2023. The archive places it in contexts such as "Phöbus’s / sun-glow". It most often appears alongside America, Ayatollah, Chris.

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Phöbus
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1
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November 07, 2023
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November 07, 2023
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Hardball Questions For The Next Debate
November 07, 2023 · Original source
TRUMP: Pour’ng / forth out of / Rus’s / rough woods; from / Muscovy’s / boroughs Gun-bulky / troops rush / forth on / Korsun’s / uncorrupt / country Just so / Cronus' / son, who / roosts on / lofty O- / lympus Puffs up / storm clouds / - so puff'd / up, so / smug Popov's / columns. But ho- / mologous / to long- / shoot’ng / Phöbus’s / sun-glow Just so / Korsun’s proud / corps burnt / through your / columns, o / Moscow. Frolov / Sokolov / Tsokov / Kozlov / sturdy Kutuzov Brought to / Cocytus; / turn’d to / bounty for / dolorous / Pluto. But not ours such / glory; / you, Vo- / lodomyr, / hog boughs of / honor Thus our / funds ought / not to sup- / ply you, your / jousts should go / solo.
pi1 mentions across 1 issues

pi is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between November 08, 2022 and November 08, 2022. The archive places it in contexts such as "rational approximation of pi as 355/113". It most often appears alongside Alexander Buhl, ANNs, Bay Area House Party.

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pi
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November 08, 2022
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November 08, 2022
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Highlights From The Comments On Brain Waves
November 08, 2022 · Original source
This turns out to be related to the size of the terms in the continued fraction expansion of a number - larger terms in the continued fraction expansion yield better approximations of your chosen value. (The unusually-good-for-its-complexity rational approximation of pi as 355/113 exists because of an unusually large term early in the continued fraction expansion of pi as [3; 7, 15, 1, 292, 1, 1, 1, 2, 1, 3, ...]. If we round the 1/292 term portion of the continued fraction to zero, we get 3+1/(7+1/(15+1/1)) = 355/113.)
piblokto1 mentions across 1 issues

piblokto is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between April 06, 2023 and April 06, 2023. The archive places it in contexts such as "Arctic hysteria, aka piblokto"; "piblokto was probably a culture-bound illness"; "piblokto, like koro, dies out as its host culture westernizes". It most often appears alongside Alaska, Alaskan government, Andamanese.

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piblokto
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1
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April 06, 2023
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April 06, 2023
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Book Review: The Arctic Hysterias
April 06, 2023 · Original source
Strange things are done in the midnight sun, say the poets who wrote of old. The Arctic trails have their secret tales that would make your blood run cold. The Northern Lights have seen queer sights, but the queerest they ever did see are chronicled in The Arctic Hysterias, psychiatrist Edward Foulks’ description of the culture-bound disorders of the Eskimos1.
Inline links: The Arctic Hysterias, 1
But the granddaddy of them all - and the namesake of Foulks’ book - is Arctic hysteria, aka piblokto. A sufferer suddenly snaps, engaging in unusual, dangerous, and violent acts. She may tear off her clothing, run out naked into the tundra, and jump into the icy water. Or she may try to kill herself or others, sometimes even her own children. Other behavior is simply bizarre: trying to walk on igloo ceilings, or gathering random rocks as if they are great treasures. When the hysteric’s friends and family notice the attack, they restrain the victim - usually it takes more than one person; an Arctic hysteric has the strength of several men. After a few minutes, the victim returns to her normal self. She remembers nothing.
In 1911, explorer Harry Whitney described a case of Arctic hysteria in Greenland:
Pickup artists1 mentions across 1 issues

Pickup artists is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between May 10, 2021 and May 10, 2021. The archive places it in contexts such as "Pickup artists (PUAs) were originally a totally different group - guys who talked a lot about the best ways to pick up girls". It most often appears alongside "How do you do, fellow kids?", #NotAllMen, #TheResistance.

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Pickup artists
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May 10, 2021
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May 10, 2021
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The Rise And Fall Of Online Culture Wars
May 10, 2021 · Original source
Earlier eras of social justice had their enemies. Around 2010, some people who didn't like feminism banded together under the umbrella of "men's rights advocates" (MRAs). Pickup artists (PUAs) were originally a totally different group - guys who talked a lot about the best ways to pick up girls - but many of them merged into the generic anti-feminist current for complicated reasons. "Red Pillers" were a third group, vaguely related to the previous two, whose main contribution to the discourse was giving us the terms "alpha male" and "beta male" (I guess these became "Chad" and "virgin" at some point). Sometimes all of these groups together called themselves "the manosphere".
When was the last time you heard people argue about "creeps", "nice guys", or "friendzoning"? Mansplaining? #NotAllMen? MRAs and PUAs? If you're in your early 20s, you might not even know what half these terms mean; if you're older than that, you’ll remember them with a sort of cold dread. But they're gone now - you'd have more luck looking for recent discourse about Osama bin Laden. Nor has some some other gender discourse arisen to replace them. Everyone just stopped caring and moved on to race.
Pick’s disease1 mentions across 1 issues

Pick’s disease is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between August 14, 2025 and August 14, 2025. The archive places it in contexts such as "distinct human tauopathies, including Pick’s disease". It most often appears alongside A. Bejanin, A. de Calignon, A. Elobeid.

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Pick’s disease
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1
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August 14, 2025
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August 14, 2025
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In Defense Of The Amyloid Hypothesis
August 14, 2025 · Original source
Overproduction or reduced clearance due to microbial infection. Amyloid-β appears to be an antimicrobial peptide and will form plaques in response to infection. [2, 3] This explains various observations that have been used to support the “infectious hypothesis”, sometimes proposed as an alternative to the amyloid hypothesis. However, it can only explain a subset of cases and, as I argue below, is even then still mediated by amyloid via an “IATN” pathway: infection → amyloid → tau → neurodegeneration. In cases of increased production, cerebrospinal fluid (CSF) will show elevated amyloid. In cases of reduced clearance, amyloid will decrease in CSF. In all cases, however, PET scans will show elevated brain amyloid, usually at first mainly in “intrinsic connectivity networks” such as the default mode network [14–20], which experience brain activity even at rest. These neurons are the most active - which causes more production and possibly less opportunity for clearance - so they tend to be the first to suffer from a production/clearance imbalance. Over time, amyloid pathology spreads spatially throughout the brain. [14, 18] Aggregations of amyloid peptides induce more such aggregations. Some of our clearest evidence for this comes from growth hormone deficiency patients, who used to have cadaver-derived ground-up brain matter injected into their own brains to provide the missing hormones. If the ground-up brain matter was sourced from the corpse of an Alzheimer’s patient, the growth hormone deficiency patients would themselves develop Alzheimer’s at a young age, probably through prion-like spread of the misfolded proteins. [21, 22] After ∼15 years of preclinical spread, the pathology eventually covers the whole brain. [14, 18] While some subtle cognitive impairment may occur during this time, it is usually not severe enough to be clinically detectable from amyloid alone. Indeed, in both humans [23–30] and mice [31–35], the severity of neurodegeneration and cognitive deficits is not a good spatiotemporal match for the severity of amyloid pathology (rather, it is a good match for the severity of tau pathology; see next section for more). These facts are often suggested as evidence against the amyloid hypothesis. However, amyloid is causally upstream of tau, as I will argue below. Therefore, the existence of cognitively normal individuals with amyloid pathology is expected in the ATN model - but typically only for a few decades, before progression to the next stage. 2: Tau pathology (T) and neurodegeneration (N) Tauopathies are a range of prion-like diseases involving the tau protein [36], whose usual function is to assist in stabilizing microtubule structure. In a tauopathy, the tau protein misfolds, and induces other, nearby tau proteins to misfold into the same shape. [37–46]. Injecting nothing but misfolded tau fibrils into a mouse brain can recruit the endogenously-produced mouse tau into this pathology, which spreads far beyond the injection site, causing neurodegeneration wherever it goes. [35, 47–59] There are at least eight distinct ways the tau protein can misfold in human disease [36], and over a dozen distinct human tauopathies, each involving a specific one of those misfoldings. These include chronic traumatic encephalopathy, Pick’s disease, corticobasal degeneration, progressive supranuclear palsy, and Alzheimer’s disease, with the last by far the most common. Each of these five diseases has its own distinct tau fold. Most normal human beings eventually develop some tau pathology in adulthood, originating probably in the locus coeruleus [60–62], which is part of the brainstem. By middle age, some amount has usually spread to the hippocampus and entorhinal cortex in the medial temporal lobe, regions responsible for episodic memory. This is called primary age-related tauopathy (PART) [63], and has its own tau fold which is distinct from most tauopathies, but the same as Alzheimer’s. [36, 64] Usually, its local severity is mild and it doesn’t spread much beyond those regions. But with sufficient amyloid pathology, this “normal” tau pathology tends to both locally worsen and spread through the rest of the brain [65], becoming the tau pathology of Alzheimer’s. Some genetic risk factors such as ApoE, in addition to affecting the clearance of amyloid-β, also increase the brain’s susceptibility to this A → T pathology conversion [66, 67]. But this is a matter of degree, as sufficient amyloid pathology seems to virtually guarantee the transition: Every 10-centiloid increase in amyloid pathology for a cognitively normal individual increases by 2.7x the probability of a PET scan detecting pathological levels of tau within five years [68]. The only known cases where patients with extremely high amyloid levels can go significant amounts of time without developing tau pathology are a few individuals with extremely rare protective genes, known only from a few case studies, e.g. [69]. Even in these instances, the individuals will eventually succumb to the tau phase, suffering neural atrophy and dementia. [70] After it forms, the tau pathology no longer appears to require amyloid’s assistance to keep spreading (although amyloid may still accelerate it). This probably explains why existing anti-amyloid therapies have been only ∼30% effective in test patients, who are usually late in the amyloid → tau progression even if early in having symptomatic disease. Neurodegeneration follows tau pathology extremely closely in time and space, in humans as well as basically all animal models, and cognitive impairments match the functions of the affected regions. There are rare reports of advanced tau pathology without cognitive decline, often in people with protective ApoE2 alleles [71], but even then, systematic analysis finds that actual density of tau inclusions is highly predictive of cognitive impairment, and that these exceptional cases usually involve widespread but locally sparse pathology [66]. The regional distribution of tau pathology explains why the first symptom of Alzheimer’s is typically impaired memory; the first cortical sites affected are usually in regions involved in memory formation. As the pathology spreads, further regions are affected, until eventually all cognitive functions are affected. As with most other aspects of the disease, the high-level picture seems relatively clear but the exact cellular and molecular pathways are not well understood (though may involve an assist from the innate immune system, especially microglia and astrocytes. [13, 35, 72]) Early Alzheimer mouse models were amyloid-only, with extremely heavy overproduction of Aβ, much more than required to recapitulate the human disease, and apparently enough to cause detectable cognitive dysfunction. However, normal mice do not get age-related tauopathy, so an amyloid-only mouse model - while useful for investigating certain questions - is not a full Alzheimer’s disease model. Combined amyloid+tau pathology mouse models, which are transgenically modified and/or injected with misfolded human tau fibrils, display the property that the presence of amyloid pathology induces the worsening and spreading of tau pathology. This is also observed in vitro in human cells. How do we know the amyloid causes the tau? Researchers have measured the correlation in many ways, from the spatiotemporal timeline (tau pathology only begins locally worsening and spreading outside the medial temporal lobe once amyloid reaches sufficient severity) [65], [98], to causal mediation modeling in the human disease [26], [99–101], to causal intervention using in vitro human cell studies [54, 102] and animal models [35, 55], [103 – 113]. But also, giving people drugs that reduce amyloid levels also decreases tau pathology. [78, 80, 82] (I’ve left out or merely alluded to much other complexity, involving the innate immune system, lipid processing, and detailed molecular and cellular mechanisms, preferring to focus on the parts of the story which are crucial to deciding the causal role of amyloid, and for which I am aware of a satisfactory account from the literature. But I don’t intend to leave the impression that the above is all there is to Alzheimer’s disease, or that all cases progress in the same exact way.) The mechanistic claims I make the following two claims about amyloid-β’s role in Alzheimer’s: Amyloid deposits are a necessary (i.e. but-for) cause in all instances of Alzheimer dementia. That is, if someone has PET or CSF positivity for amyloid and tau pathologies, and the tau pathology involves the Alzheimer tau fold and made its first cortical appearance in the medial temporal lobe, and then they developed medial temporal volume loss + amnestic mild cognitive impairment + later dementia, then counterfactually, early enough (probably ∼15 years before clinical presentation) causal intervention solely to remove the amyloid deposits would have prevented almost all tau pathology and symptoms.
Inline links: below, probably through prion-like spread of the misfolded proteins, 10-centiloid, have been, the presence of amyloid pathology induces the worsening and spreading of tau pathology
Pietists1 mentions across 1 issues

Pietists is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between August 11, 2023 and August 11, 2023. The archive places it in contexts such as "Then the later Puritans and Pietists, copying back from Counter-Reformation spirituality". It most often appears alongside Achilles, ACX, Adam Smith.

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Pietists
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August 11, 2023
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August 11, 2023
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Your Book Review: The Weirdest People in the World
August 11, 2023 · Original source
Here’s one thing that looks to me like a historically extended push: from the earliest Reformers onwards, the constant drive towards character education. It starts with Lutherans trying and failing to reform the country peasants by teaching them their catechism5. Then the later Puritans and Pietists, copying back from Counter-Reformation spirituality, going deeper into themselves before they try to change the world; the first children’s books, the great spiritual classics like Pilgrim’s Progress. Then the secular 18th century experimenters like Rousseau; and the first state education systems – all universally agreed that the point of education is character, not technical skills; and mostly within a broadly Christian framework.
Inline links: 5
pig kidney1 mentions across 1 issues

pig kidney is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between June 28, 2024 and June 28, 2024. The archive places it in contexts such as "first ever successful transplant of a pig kidney that was genetically designed to be used in humans". It most often appears alongside 2023 special, ACX grant winners, African Gray Parrot.

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pig kidney
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1
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June 28, 2024
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June 28, 2024
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Your Book Review: Dominion
June 28, 2024 · Original source
But what if we turn to the guy who recently went through the first ever successful transplant of a pig kidney that was genetically designed to be used in humans? I bet he’d consider all the previous carnage a necessary evil indeed.
Inline links: first ever successful transplant
pig kidneys1 mentions across 1 issues

pig kidneys is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between November 07, 2023 and November 07, 2023. The archive places it in contexts such as "There are groups working on using pig kidneys". It most often appears alongside Aceso Under Glass, ACX Grant, America.

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pig kidneys
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November 07, 2023
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November 07, 2023
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Highlights From The Comments On Kidney Donation
November 07, 2023 · Original source
There are groups working on using pig kidneys. Pig kidneys on their own are not compatible with humans, there will be a very strong acute immune response that will cause necrosis of the kidney and rejection. So these groups change certain genes to reduce the immunogenicity of the pig kidneys. This is hard, there are some prime immune targets, which you can do things about. But there are a lot of antigens the immune system can target. Just from memory I think the most one could stay implanted in a non-human primate under strong immune suppression was a few hundred days.
There are also the chiral approaches which I think you linked to. The end result is a combination of some pig and some human cells which might be less of an issue immunity than the full pig kidneys I mentioned before but still has challenges.
Pigouvian taxes1 mentions across 1 issues

Pigouvian taxes is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between December 09, 2021 and December 09, 2021. The archive places it in contexts such as "Other taxes with no deadweight loss include Pigouvian taxes on bad things". It most often appears alongside 2017 PTAPP survey, AEI, agglomeration effect.

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Pigouvian taxes
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1
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December 09, 2021
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December 09, 2021
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Does Georgism Work? Part 1: Is Land Really A Big Deal?
December 09, 2021 · Original source
...hat LVT has zero "deadweight loss"–a fancy word for a drag on the economy that makes certain activities no longer profitable. Other taxes with no deadweight loss include Pigouvian taxes on bad things, like congestion and pollution. But won't landlords just raise the rent to make up for the LVT, passing the burden of the tax on to the tenants? Georgists...
Pilgrim1 mentions across 1 issues

Pilgrim is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between February 26, 2021 and February 26, 2021. The archive places it in contexts such as "Pilgrim (vegan turkey and cranberry)". It most often appears alongside American Chinese food, Bay Area, BBQ pork rice.

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Pilgrim
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1
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February 26, 2021
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February 26, 2021
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Bay Area Plant-Based Meat Reviews
February 26, 2021 · Original source
I ordered Ike's Meatless Mike (vegan meatballs, marinara, and pepper jack), Handsome Owl (vegan chicken, wasabi mayo, and swiss), and Pilgrim (vegan turkey and cranberry). I ordered Crave's Charmander (vegan meatballs, marinara, and provolone), Goku (vegan chicken, BBQ sauce, and pepper jack), and Kim Possible (vegan impossible patty, Swiss, and mushrooms).
Ike's Pilgrim was great. I can't tell the difference between their veggie turkey and the real thing. I'm not sure a turkey and cranberry sandwich is really what I want, but insofar as it is, this absolutely satisfies that urge.
If you don’t want a burger and you don’t want Chinese, I recommend Ike’s sandwiches, especially the Pilgrim.
Inline links: Ike’s sandwiches
pilot whales1 mentions across 1 issues

pilot whales is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between May 04, 2022 and May 04, 2022. The archive places it in contexts such as "It all started when I learned about pilot whales". It most often appears alongside 1000, 1200, 1400.

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pilot whales
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1
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1
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May 04, 2022
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May 04, 2022
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Every Bay Area House Party
May 04, 2022 · Original source
“Both! It all started when I learned about pilot whales. See, we used to think that humans had the biggest brain relative to their body size, and that’s why we were so smart. But it turns out there are loads of animals with bigger brain:body ratios. So it’s got to be something more complicated. People have come up with a lot of measures for calculating animal intelligence: encephalization quotient, neuron number. If you combine them all together, you can get one that mostly makes sense, with the dumbest insects at the bottom and humans on the top. The only exception is pilot whales. However you calculate it out, they should be smarter than we are.”
“So I looked up what pilot whales did, and the answer was mostly that they seem to swim up onto beaches and die of dehydration unless they can flop their way back into the sea. Nobody knows why. I sure don’t. But I figure, if they’re smarter than we are, there must be some reason for it. Maybe it’s The Good. You know, like the moral law. I’m not sure. I just feel like it’s an underexplored possibility. So I’m traveling to beaches across the world so I can lie naked on them and almost die of dehydration. And if I learn something important, I’ll write an article about it.”
Pink noise1 mentions across 1 issues

Pink noise is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between October 20, 2022 and October 20, 2022. The archive places it in contexts such as "Pink noise was named because its wave spectrum resembles pink light". It most often appears alongside Alpha, Andres, Brown noise.

Reference entry
Pink noise
Mention count
1
Issue count
1
First seen
October 20, 2022
Last seen
October 20, 2022
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Book Review: Rhythms Of The Brain
October 20, 2022 · Original source
You get concentric rings of oscillating on and off! I can’t stress enough how fake this model is. Buzsaki doesn’t use it; even his simplified examples are much more careful. But this was what helped me (a person who is not a neuroscientist but does play around with Conway’s Game of Life sometimes) get a basic intuition of why the brain might produce oscillations. Here are five of the most important differences between this fake model and a real brain: 1: The real brain has more sources of oscillations. For example, many are produced by inhibitory interneurons - neurons that, when turned “on”, turn other neurons off: A normal excitatory neuron is linked to an inhibitory neuron. Whenever the excitatory neuron fires, it makes the inhibitory neuron fire; whenever the inhibitor neuron fires, it turns off the excitatory neuron. Once the excitatory neuron is off, that turns off the inhibitory neuron, leaving the excitatory neuron free to fire again if the original stimulus is still there. 2: Also, sometimes individual neurons oscillate on their own. Whenever they get too depolarized, that opens ion channels that repolarize them again, and vice versa. If you take a neuron out of the brain and put it in a test tube, it might fire at some natural frequency not necessarily related to its frequency in the broader network of the brain; it contributes its own frequency, which other nearby cells speed up or slow down. 3: In the fake model, every neuron was connected to a few nearby neighbors. The real brain has a much more complicated graph. Neurons can connect to thousands of other neurons, and one out of every X connections goes somewhere far away on the other side of the brain, for the same reason a good transportation network has some local trains vs. some express trains - you can get from Point A to Point B fastest with a combination of fast direct long-range connections and slower short-range ones. 4: The real brain includes many different kinds of neurons, inhibitory neurons, connections between neurons, and types of tissues with different graph theoretic organizations. If the fake model is kind of like the Game of Life, the real model is kind of like a version of the Game of Life in some contorted multidimensional space with each cell following a different rule set. 5: Also there is actual sensory stimulation and cognition happening in lots of places at once, messing up the otherwise elegant wave pattern. So instead of one oscillation taking over the whole brain, you get lots of oscillations with different properties arising, competing against, and interfering with each other, producing complicated self-organizing patterns that arise and disappear from moment to moment Complex patterns arising and evolving in the Game of Life. What Are Brain Waves Like? In the real brain, with many areas and types of neurons and sources of stimulation, the many different oscillations settle into what Buzsaki calls a 1/n, scale-free, or pink noise pattern. Complex waves can be decomposed by Fourier analysis into sums of simpler regular waves: (source) If you measure “brain waves” with an EEG, you get some very complex summed total wave. When you break it down, you find that as frequency goes up, power goes down, according to a power law. In the study of sound, this pattern is called “pink noise”. (source) Pink noise is apparently omnipresent in natural systems for kind of mysterious reasons - see eg this Quanta article, which says pink noise “is found in all kinds of electrical noise, stock market activity, biological rhythms, and even pieces of music — and no one [knows] why.” Buzsaki is pretty excited about this, and suggests that human-produced music has a pink noise spectrum in order to complement the pink noise spectrum of the brain; other sources argue that literal pink noise (for example, from a fan) has healing properties compared to white noise or silence. Did you know: White noise was named because its wave spectrum resembles white light. Pink noise was named because its wave spectrum resembles pink light. Brown noise was named after Robert Brown, who helped discover it. This is one of my least favorite facts. Lots of scientists seem tempted to wax rhapsodic about the importance of pink noise; the exact reasons were one of the parts of the book I didn’t quite understand. For our purposes, it just matters that this is the overall wave spectrum of the brain. How is this spectrum formed? This was one of the questions the book didn’t resolve for me. Are there a few hundred neurons here oscillating at 1 hertz, a few thousand there oscillating at 1.1 hertz, and so on, until we have enumerated thousands of different neuronal populations with very slightly different rhythms, and when you add them together you get the nice smooth pink noise curve? And then after a second, they all spontaneously rearrange themselves and there are a different few thousand populations and rhythms, still on the aggregate summing to pink noise? Sometimes it seems like the book is pointing to a model like this. Other times it seems like there are approximately five different rhythms in the brain, each with a name like “hippocampal theta” or “visual alpha”, and each usually involving a whole brain macroregion (eg the visual cortex). I still haven’t figured out how to reconcile these two perspectives - maybe the major rhythms are broad categories, and there are lots of subrhythms within them? In any case, these 1/n rhythms form the “background noise” of the brain. They exist at all times, whether you’re thinking hard, or in a sensory deprivation tank, or asleep (although each of those states will change which rhythm predominates). When neuroscientists want to study how the brain reacts to something, they usually measure the brain, do the thing, and subtract the pink noise spectrum from the result - again, on the grounds that it’s “background noise” which is disguising the effect of whatever their interesting intervention was. Buzsaki questions this practice and presents evidence that the state of the “background noise” matters a lot - this is the “randomness” that explains why the same person will respond to the same intervention different ways at different times. For example, he presents evidence showing that if you give someone a near-threshold stimulus (for example, a flashing light just barely bright enough that someone can detect it 50% of the time), then whether they detect it or not will depend on whether it occurs at the peak or the trough of the brain waves in the relevant area. Are Brain Waves Useful? Brain waves are kind of unavoidable. Rhythms presents a thought experiment about trying to design a brain that doesn’t fall into any natural oscillatory patterns. It’s pretty hard! Even if brain waves were useless, we would probably have them just because they’re too much trouble to avoid. Still, evolution tends to make virtues out of necessity, and Buzsaki thinks brain waves matter a lot. Again without claiming to have fully understood this, here are four things that brain waves might do: Brain waves provide “synchrony”, allowing a smallest granular unit of time and essentially converting life into a turn-based game. Suppose that a snake bites your foot. You see the snake with your eyes, and also get a pain signal from your foot. The pain signal has to travel a long way, nerves have conduction delays, and so it reaches your brain well after the visual signal. But your brain needs to be able to combine the visual and pain signals into a single story (snake bit my foot). Brain waves separate experience into short granular “turns” so that the brain can attribute both stimuli to the same “turn” and connect them. It’s also possible I’m totally misunderstanding this part, sorry.
Inline links: https://substackcdn.com/image/fetch/$s_!vg24!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2Fbf360690-6ffc-41d9-8e6f-056bbe9e033e_1920x278.png, https://substackcdn.com/image/fetch/$s_!zvsa!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F36224fdc-b706-4f38-8989-135b68f77668_360x240.gif, https://substackcdn.com/image/fetch/$s_!_l2P!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F4b25b1e9-86ca-4d85-9d31-cc93472c5cf2_401x302.gif, source, https://substackcdn.com/image/fetch/$s_!JqB5!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2Fca9fb777-23a6-4cf4-b997-15e5861c5541_555x374.png, source, other sources argue, https://substackcdn.com/image/fetch/$s_!0bfI!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F75286799-6c21-4dda-be19-12e4b2410dbc_389x369.png
(source) If you measure “brain waves” with an EEG, you get some very complex summed total wave. When you break it down, you find that as frequency goes up, power goes down, according to a power law. In the study of sound, this pattern is called “pink noise”. (source) Pink noise is apparently omnipresent in natural systems for kind of mysterious reasons - see eg this Quanta article, which says pink noise “is found in all kinds of electrical noise, stock market activity, biological rhythms, and even pieces of music — and no one [knows] why.” Buzsaki is pretty excited about this, and suggests that human-produced music has a pink noise spectrum in order to complement the pink noise spectrum of the brain; other sources argue that literal pink noise (for example, from a fan) has healing properties compared to white noise or silence. Did you know: White noise was named because its wave spectrum resembles white light. Pink noise was named because its wave spectrum resembles pink light. Brown noise was named after Robert Brown, who helped discover it. This is one of my least favorite facts. Lots of scientists seem tempted to wax rhapsodic about the importance of pink noise; the exact reasons were one of the parts of the book I didn’t quite understand. For our purposes, it just matters that this is the overall wave spectrum of the brain. How is this spectrum formed? This was one of the questions the book didn’t resolve for me. Are there a few hundred neurons here oscillating at 1 hertz, a few thousand there oscillating at 1.1 hertz, and so on, until we have enumerated thousands of different neuronal populations with very slightly different rhythms, and when you add them together you get the nice smooth pink noise curve? And then after a second, they all spontaneously rearrange themselves and there are a different few thousand populations and rhythms, still on the aggregate summing to pink noise? Sometimes it seems like the book is pointing to a model like this. Other times it seems like there are approximately five different rhythms in the brain, each with a name like “hippocampal theta” or “visual alpha”, and each usually involving a whole brain macroregion (eg the visual cortex). I still haven’t figured out how to reconcile these two perspectives - maybe the major rhythms are broad categories, and there are lots of subrhythms within them? In any case, these 1/n rhythms form the “background noise” of the brain. They exist at all times, whether you’re thinking hard, or in a sensory deprivation tank, or asleep (although each of those states will change which rhythm predominates). When neuroscientists want to study how the brain reacts to something, they usually measure the brain, do the thing, and subtract the pink noise spectrum from the result - again, on the grounds that it’s “background noise” which is disguising the effect of whatever their interesting intervention was. Buzsaki questions this practice and presents evidence that the state of the “background noise” matters a lot - this is the “randomness” that explains why the same person will respond to the same intervention different ways at different times. For example, he presents evidence showing that if you give someone a near-threshold stimulus (for example, a flashing light just barely bright enough that someone can detect it 50% of the time), then whether they detect it or not will depend on whether it occurs at the peak or the trough of the brain waves in the relevant area. Are Brain Waves Useful? Brain waves are kind of unavoidable. Rhythms presents a thought experiment about trying to design a brain that doesn’t fall into any natural oscillatory patterns. It’s pretty hard! Even if brain waves were useless, we would probably have them just because they’re too much trouble to avoid. Still, evolution tends to make virtues out of necessity, and Buzsaki thinks brain waves matter a lot. Again without claiming to have fully understood this, here are four things that brain waves might do: Brain waves provide “synchrony”, allowing a smallest granular unit of time and essentially converting life into a turn-based game. Suppose that a snake bites your foot. You see the snake with your eyes, and also get a pain signal from your foot. The pain signal has to travel a long way, nerves have conduction delays, and so it reaches your brain well after the visual signal. But your brain needs to be able to combine the visual and pain signals into a single story (snake bit my foot). Brain waves separate experience into short granular “turns” so that the brain can attribute both stimuli to the same “turn” and connect them. It’s also possible I’m totally misunderstanding this part, sorry.
Inline links: source, https://substackcdn.com/image/fetch/$s_!JqB5!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2Fca9fb777-23a6-4cf4-b997-15e5861c5541_555x374.png, source, other sources argue, https://substackcdn.com/image/fetch/$s_!0bfI!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F75286799-6c21-4dda-be19-12e4b2410dbc_389x369.png
(source) Pink noise is apparently omnipresent in natural systems for kind of mysterious reasons - see eg this Quanta article, which says pink noise “is found in all kinds of electrical noise, stock market activity, biological rhythms, and even pieces of music — and no one [knows] why.” Buzsaki is pretty excited about this, and suggests that human-produced music has a pink noise spectrum in order to complement the pink noise spectrum of the brain; other sources argue that literal pink noise (for example, from a fan) has healing properties compared to white noise or silence. Did you know: White noise was named because its wave spectrum resembles white light. Pink noise was named because its wave spectrum resembles pink light. Brown noise was named after Robert Brown, who helped discover it. This is one of my least favorite facts. Lots of scientists seem tempted to wax rhapsodic about the importance of pink noise; the exact reasons were one of the parts of the book I didn’t quite understand. For our purposes, it just matters that this is the overall wave spectrum of the brain. How is this spectrum formed? This was one of the questions the book didn’t resolve for me. Are there a few hundred neurons here oscillating at 1 hertz, a few thousand there oscillating at 1.1 hertz, and so on, until we have enumerated thousands of different neuronal populations with very slightly different rhythms, and when you add them together you get the nice smooth pink noise curve? And then after a second, they all spontaneously rearrange themselves and there are a different few thousand populations and rhythms, still on the aggregate summing to pink noise? Sometimes it seems like the book is pointing to a model like this. Other times it seems like there are approximately five different rhythms in the brain, each with a name like “hippocampal theta” or “visual alpha”, and each usually involving a whole brain macroregion (eg the visual cortex). I still haven’t figured out how to reconcile these two perspectives - maybe the major rhythms are broad categories, and there are lots of subrhythms within them? In any case, these 1/n rhythms form the “background noise” of the brain. They exist at all times, whether you’re thinking hard, or in a sensory deprivation tank, or asleep (although each of those states will change which rhythm predominates). When neuroscientists want to study how the brain reacts to something, they usually measure the brain, do the thing, and subtract the pink noise spectrum from the result - again, on the grounds that it’s “background noise” which is disguising the effect of whatever their interesting intervention was. Buzsaki questions this practice and presents evidence that the state of the “background noise” matters a lot - this is the “randomness” that explains why the same person will respond to the same intervention different ways at different times. For example, he presents evidence showing that if you give someone a near-threshold stimulus (for example, a flashing light just barely bright enough that someone can detect it 50% of the time), then whether they detect it or not will depend on whether it occurs at the peak or the trough of the brain waves in the relevant area. Are Brain Waves Useful? Brain waves are kind of unavoidable. Rhythms presents a thought experiment about trying to design a brain that doesn’t fall into any natural oscillatory patterns. It’s pretty hard! Even if brain waves were useless, we would probably have them just because they’re too much trouble to avoid. Still, evolution tends to make virtues out of necessity, and Buzsaki thinks brain waves matter a lot. Again without claiming to have fully understood this, here are four things that brain waves might do: Brain waves provide “synchrony”, allowing a smallest granular unit of time and essentially converting life into a turn-based game. Suppose that a snake bites your foot. You see the snake with your eyes, and also get a pain signal from your foot. The pain signal has to travel a long way, nerves have conduction delays, and so it reaches your brain well after the visual signal. But your brain needs to be able to combine the visual and pain signals into a single story (snake bit my foot). Brain waves separate experience into short granular “turns” so that the brain can attribute both stimuli to the same “turn” and connect them. It’s also possible I’m totally misunderstanding this part, sorry.
Inline links: source, other sources argue, https://substackcdn.com/image/fetch/$s_!0bfI!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F75286799-6c21-4dda-be19-12e4b2410dbc_389x369.png
Pinyin1 mentions across 1 issues

Pinyin is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between August 19, 2022 and August 19, 2022. The archive places it in contexts such as "the Wade-Giles and Pinyin approaches are the two main methods". It most often appears alongside 1587, 1587, 1587, A Year of No Significance: The Ming Dynasty in Decline.

Reference entry
Pinyin
Mention count
1
Issue count
1
First seen
August 19, 2022
Last seen
August 19, 2022
Outbound links
Issue trail
Related pages
Source context
Your Book Review: 1587, A Year Of No Significance
August 19, 2022 · Original source
It’s challenging to represent Chinese words in alphabetical form; the Wade-Giles and Pinyin approaches are the two main methods. This book, from 1981, uses the older Wade-Giles system. On the other hand, a nice benefit of this book's age is that it remains blessedly uncontaminated by any current “culture war” toxicity. Many of the main characters have Wikipedia pages under the newer Pinyin versions of their names, which I'll link. I’ll also include the Pinyin version in parentheses where the spelling of the Wade-Giles version is significantly different, like this: Peking (Beijing).
The main man in this story is known as the Wan-Li Emperor. His family name was Chu (Wade-Giles) or Zhu (in Pinyin). His personal name combined the characters for “joy” and “king.” Like most high-ranking individuals of his day, he had way too many other official names and titles - this book, to my relief, doesn’t go down that rabbithole. Our author sticks to calling him “Wan-li.”
Inline links: Wan-Li Emperor
Pioneer plaque1 mentions across 1 issues

Pioneer plaque is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between February 09, 2023 and February 09, 2023. The archive places it in contexts such as ""His second wife drew the Pioneer plaque"". It most often appears alongside @moritheil, ACX Prediction Contest, Adam Tooze.

Reference entry
Pioneer plaque
Mention count
1
Issue count
1
First seen
February 09, 2023
Last seen
February 09, 2023
Outbound links
Issue trail
Related pages
Source context
Links For February 2023
February 09, 2023 · Original source
In theory this also paves the way for human meat, though regulators might have other ideas. 2: Eight years ago I wrote an article about how the government should stop restricting doctors’ ability to prescribe suboxone, a useful medicine for opioid abuse. Last month, the government finally stopped the restrictions. Good for them! 3: Carl Sagan married three times. His first wife was legendary biologist Lynn Margulis, who discovered mitochondrial endosymbiosis, then went off the deep end and became an AIDS denialist and 9/11 truther. His second wife drew the Pioneer plaque. His third wife was one of the women who designed the Voyager golden record. 4: Claim: Chinese sources seem to back this up (and related BBC), but I’m skeptical: is this really the best way to satisfy a “must fight with medieval weapons” constraint? Why not crossbows? 5: Did you know: Alex Berenson, who runs the most popular anti-vaccine Substack, has had an unusual career: he used to be an investigative reporter for the New York Times, and also wrote a series of bestselling spy novels. 6: Less Wrong: I Converted Book 1 Of The Less Wrong Sequences Into A Zoomer-Readable Format. Apparently there’s a thing where Zoomers are supposedly more likely to learn a text if you overlay it on on a fast-paced video game, example here. 7: By this point we’ve probably all heard stories about people who win the lottery and then end up bankrupt and miserable after X months or years. I had always assumed this was limited to very poor people with no understanding of money. This forum post argues it’s not, and tells the story of a man who started out with $15 million and still ruined his life after winning $170 million more in the lottery. 8: Did you know: Exiliarch Mar-Zutra II was a 5th century Jewish leader who took advantage of the chaos caused by weird Zoroastrian communists to secede and turn the city of Al-Mada’in, Iraq into an independent Jewish state for seven years. 9: Why doesn’t the Supreme Court have vice-justices? 10: Steve Sailer (warning: unz.com, far-right site, some firewalls will flag or block it): why aren’t there more gay English soccer players? Thousands of current or recent English pro soccer players, the media is really interested in finding a gay one so they can run a “Historic First” article, and apparently they can’t. There are rumors that players are afraid to come out because of homophobia, but there are at least 2,000 retired soccer players and only one of them has come out as gay. “I’m increasingly sympathetic to [the] theory that whatever psychosocial traits make men highly interested in team sports make them highly heterosexual too”. Is this true of other countries and other sports? 11: Adam Tooze on the demographic background to Iran’s protests. Iran thought it was facing an overpopulation crisis in the 80s and tried some reforms to lower family size. The reforms worked overwhelmingly well, causing “the most dramatic transition ever recorded in demographic history”, from 6.5 to 2.5 children per woman in thirty years. Iran now has “lower maternal mortality than the US”, and an education system where “women in university outnumber males”. This kind of demography isn’t usually compatible with patriarchal religious institutions, and the Ayatollahs are aware of this; in a rare admission of error, Khameini said that “Government officials were wrong on this matter, and I, too, had a part. . . . May God and history forgive us.” Now they’re trying to increase average family size and put the genie back in the bottle; Hungary can tell them about the limits of that strategy. 12: What it looks like to be on shrooms: I haven’t used shrooms myself so cannot confirm or deny, but this is oddly compelling, and makes some things I’ve read about neuroscience of vision make more sense. I wonder if you could get HPPD from watching videos like this for too long. 13: Study: federal cancer funding is extraordinarily effective. Cancer research produces so many valuable treatments that it saves one DALY per $326 spent. For comparison, health systems usually consider an intervention good value-for-money if it saves at least one DALY per $50,000. By combing the Earth far and wide, effective altruists have tentatively found one or two opportunities in the poorest parts of Africa to save lives at $100/DALY, but these are extremely rare exceptions and I wouldn’t have expected anything in the US to be within an order of magnitude of that. Either this finding is fake, or we should all be donating to federal cancer research instead of whatever else we’re doing. 14: Yet another person building a vast theory of human interaction off of the characters in The Office. This one is pretty good, also name-drops Bobos In Paradise. I’m still surprised this is such a common thing. 15: Marginal Revolution: FDA Deregulation Increases Safety And Innovation And Reduces Prices. Study looks at what happens when the FDA reclassifies medical devices from a highly-regulated to a less-highly-regulated category; in general, those devices get better, cheaper, and there are somewhere between similar and fewer deaths/injuries related to those devices. Why would safety increase? The author suggests that regulation is a defense against lawsuits (“Your Honor, the FDA agreed to approve our device, so it can’t have been bad!”), and removing that defense makes companies more lawsuit-conscious and careful; Alex Tabarrok suggests a bigger effect may be allowing more innovation towards safer versions. 16: Ozy writes about Interesting People Of History: Charles Williams (ie the other member of the Inklings) 17: Did you know: the Congressman who founded the House Committee On Un-American Activities was, in fact, a paid Soviet spy (tweet, Wiki article). This actually makes sense; he originally started HUAC to root out fascists, and it only got turned against communists later on. “There has been a push to rename the street [currently named after the Soviet spy], but as of 2018 it has been unsuccessful.” 18: Idle Words: Why Not Mars? Surprisingly strong argument for why sending humans to Mars is harder than people think, of minimal scientific value, and likely to contaminate all future searches for microbial life and ruin our chance to study the topic. Concludes that we should abandon the allure of human space travel and just send probes everywhere. This makes short-term sense, but I wonder what this author’s vision of the future is - do we just stay on Earth forever? If not, don’t we have to start trying to do the hard thing at some point? (I don’t care about this because I assume AI will will flip the gameboard one way or another, but Ceglowski is a noted singularity skeptic and should probably have opinions about long-term things). 19: Metacelsus and Razib on epigenetics. Stop using it to claim there’s “intergenerational trauma”! 20: Tafl games are a family of European games, played in areas as diverse as Iceland, Ireland, Britain, and Denmark, probably sharing descent from a now-lost board game of ancient Rome. One of them, Hnetafl, was the chief board game of the Vikings and is affectionately called “Viking chess”. The one we actually know the rules for is the Saami version, Tablut, which survived long enough for Linnaeus (the taxonomy guy!) to write down the rules. 21: Shot: Chaser: (source) 22: Related: the very center of GPT’s embedding space contains a few unusual tokens including the string “SolidGoldMagikarp”. GPT displays anomalous behavior if these tokens are inserted in a query; for example, it treats “SolidGoldMagikarp” as the word “distribute”. ChatGPT is pretty advanced and fails semi-gracefully here; GPT-2’s reaction to these tokens is more disturbing: (source: Less Wrong) Further investigation determined that many of these tokens are the screen names of a group of Redditors who attempted to count to infinity. The most likely explanation, according to the discoverers, is that these names were in GPT’s tokenization data, but not its training data (maybe they were especially common in the tokenization data because they made thousands of posts with numbers in them, but didn’t make it into the training data because their posts had no content?) - that leaves them existing without content, and GPT tries to round them off to some other “nearby” token (by incomprehensible AI standards of nearbyness). Congrats to the SERI-MATS AI alignment researchers who found all of this; maybe this makes it 0.0001% less likely that the AI which controls the nuclear arsenal in twenty years will have equally inexplicable behavior. 23: More language model news: LLM that understands and can explain images
Inline links: I wrote an article about how, finally stopped the restrictions, married three times, Lynn Margulis, drew the, Chinese, and related BBC, Alex Berenson, I Converted Book 1 Of The Less Wrong Sequences Into A Zoomer-Readable Format, example here, This forum post argues it’s not, Exiliarch Mar-Zutra II, weird Zoroastrian communists, vice-justices, why aren’t there more gay English soccer players?, Adam Tooze on the demographic background to Iran’s protests, federal cancer funding is extraordinarily effective, Yet another person building a vast theory of human interaction off of the characters in, FDA Deregulation Increases Safety And Innovation And Reduces Prices, Interesting People Of History: Charles Williams, tweet, Wiki article, Why Not Mars?, Metacelsus, Razib, Tafl games, Tablut, https://substackcdn.com/image/fetch/$s_!EhT-!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F39755d06-3101-44d5-bb50-0a6b99155fae_807x776.png, source, contains a few unusual tokens, https://substackcdn.com/image/fetch/$s_!rkvW!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fdeb0cd39-6942-44c0-85ef-0fac91b362e3_536x147.png, https://substackcdn.com/image/fetch/$s_!QIzo!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fba1d0783-5826-48a3-9ead-1e803042e96d_622x631.png, Less Wrong, many of these tokens are the screen names of a group of Redditors who attempted to count to infinity, SERI-MATS, LLM that understands and can explain images
Piraha1 mentions across 1 issues

Piraha is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between September 15, 2023 and September 15, 2023. The archive places it in contexts such as "discussion of the Piraha (the weird tribe)". It most often appears alongside @campeters4, A Strange Dream, a_reader.

Reference entry
Piraha
Mention count
1
Issue count
1
First seen
September 15, 2023
Last seen
September 15, 2023
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Source context
Book Review Contest 2023 Winners
September 15, 2023 · Original source
Some extra praise: Man's Search For Meaning placed 4th; I thought it was a good review of an important book by someone who's clearly thought about these issues a lot. I loved Public Citizen; I had a vague sense that a lot of government happens by lawsuit now and it hadn't always been this way, but I wouldn't have even known where to start in figuring out why and how this happened, and I had always thought of Nader as "that car guy who everyone mysteriously thought was important who then lost the 2000 election", so I'm glad to get more clarity there. Zuozhuan was oddly haunting and I will remember the part about Zichan and the law code for a long time. Don't Sleep, There Are Snakes was a discussion of the Piraha (the weird tribe that doesn't seem to have supposedly universal features of language and culture) which gave a great sense of how it might feel to be a primitive rainforest tribe.
Pirahã1 mentions across 1 issues

Pirahã is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between July 19, 2024 and July 19, 2024. The archive places it in contexts such as "Everett’s first encounter with the Pirahã"; "use of the Pirahãs"; "language reflect core tenets of Pirahã culture". It most often appears alongside Alan Turing, Amazon, Amazon jungle.

Reference entry
Pirahã
Mention count
1
Issue count
1
First seen
July 19, 2024
Last seen
July 19, 2024
Outbound links
Issue trail
Related pages
Source context
Your Book Review: How Language Began
July 19, 2024 · Original source
This is what he looks like. According to Wikipedia, the context for this picture is: “Noam Chomsky speaks about humanity's prospects for survival” Since around 1957, Chomsky has dominated linguistics. And this matters because he is kind of a contrarian with weird ideas. Is language for communicating? No, it’s mainly for thinking: (What Kind of Creatures Are We? Ch. 1, pg. 15-16) It is, indeed, virtual dogma that the function of language is communication. ... there is by now quite significant evidence that it is simply false. Doubtless language is sometimes used for communication, as is style of dress, facial expression and stance, and much else. But fundamental properties of language design indicate that a rich tradition is correct in regarding language as essentially an instrument of thought, even if we do not go as far as Humboldt in identifying the two. Should linguists care about the interaction between culture and language? No, that’s essentially stamp-collecting: (Language and Responsibility, Ch. 2, pg. 56-57) Again, a discipline is defined in terms of its object and its results. Sociology is the study of society. As to its results, it seems that there are few things one can say about that, at least at a fairly general level. One finds observations, intuitions, impressions, some valid generalizations perhaps. All very valuable, no doubt, but not at the level of explanatory principles. … Sociolinguistics is, I suppose, a discipline that seeks to apply principles of sociology to the study of language; but I suspect that it can draw little from sociology, and I wonder whether it is likely to contribute much to it. … You can also collect butterflies and make many observations. If you like butterflies, that’s fine; but such work must not be confounded with research, which is concerned to discover explanatory principles of some depth and fails if it has not done so. Did the human capacity for language evolve gradually? No, it suddenly appeared around 50,000 years ago after a freak gene mutation: (Language and Mind, third edition, pg, 183-184) An elementary fact about the language faculty is that it is a system of discrete infinity, rare in the organic world. Any such system is based on a primitive operation that takes objects already constructed, and constructs from them a new object: in the simplest case, the set containing them. Call that operation Merge. Either Merge or some equivalent is a minimal requirement. With Merge available, we instantly have an unbounded system of hierarchically structured expressions. The simplest account of the “Great Leap Forward” in the evolution of humans would be that the brain was rewired, perhaps by some slight mutation, to provide the operation Merge … There are speculations about the evolution of language that postulate a far more complex process … A more parsimonious speculation is that they did not, and that the Great Leap was effectively instantaneous, in a single individual, who was instantly endowed with intellectual capacities far superior to those of others, transmitted to offspring and coming to predominate. At best a reasonable guess, as are all speculations about such matters, but about the simplest one imaginable, and not inconsistent with anything known or plausibly surmised. It is hard to see what account of human evolution would not assume at least this much, in one or another form. I think all of these positions are kind of insane for reasons that we will discuss later. (Side note: Chomsky’s proposal is essentially the hard takeoff theory of human intelligence.) Most consequential of all, perhaps, are the ways Chomsky has influenced (i) what linguists mainly study, and (ii) how they go about studying it. Naively, since language involves many different components—including sound production and comprehension, intonation, gestures, and context, among many others—linguists might want to study all of these. While they do study all of these, Chomsky and his followers view grammar as by far the most important component of humans’ ability to understand and produce language, and accordingly make it their central focus. Roughly speaking, grammar refers to the set of language-specific rules that determine whether a sentence is well-formed. It goes beyond specifying word order (or ‘surface structure’, in Chomskyan terminology) since one needs to know more than just where words are placed in order to modify or extend a given sentence. Consider a pair of sentences Chomsky uses to illustrate this point in Aspects of the Theory of Syntax (pg. 22), his most cited work: (1a) I expected John to be examined by a specialist. (2a) I persuaded John to be examined by a specialist. The words “expected” and “persuaded” appear in the same location in each sentence, but imply different ‘latent’ grammatical structures, or ‘deep structures’. One way to show this is to observe that a particular way of rearranging the words produces a sentence with the same meaning in the first case (1a = 1b), and a different meaning in the second (2a != 2b): (1b) I expected a specialist to examine John. (2b) I persuaded a specialist to examine John. In particular, the target of persuasion is “John” in the case of (2a), and “the specialist” in the case of (2b). A full Chomskyan treatment of sentences like this would involve hierarchical tree diagrams, which permit a precise description of deep structure. You may have encountered the famous sentence: “Colorless green ideas sleep furiously.” It first appeared in Chomsky’s 1957 book Syntactic Structures, and the point is that even nonsense sentences can be grammatically well-formed, and that speakers can quickly assess the grammatical correctness of even nonsense sentences that they’ve never seen before. To Chomsky, this is one of the most important facts to be explained about language. A naive response to Chomsky’s preoccupation with grammar is: doesn’t real language involve a lot of non-grammatical stuff, like stuttering and slips of the tongue and midstream changes of mind? Of course it does, and Chomsky acknowledges this. To address this point, Chomsky has to move the goalposts in two important ways. First, he famously distinguishes competence from performance, and identifies the former as the subject of any serious theory of language: (Aspects of the Theory of Syntax, Ch. 1, pg. 4) The problem for the linguist, as well as for the child learning the language, is to determine from the data of performance the underlying system of rules that has been mastered by the speaker-hearer and that he puts to use in actual performance. Hence, in the technical sense, linguistic theory is mentalistic, since it is concerned with discovering a mental reality underlying actual behavior. Observed use of language or hypothesized dispositions to respond, habits, and so on, may provide evidence as to the nature of this mental reality, but surely cannot constitute the actual subject matter of linguistics, if this is to be a serious discipline. Moreover, he claims that grammar captures most of what we should mean when we talk about speakers’ linguistic competence: (Aspects of the Theory of Syntax, Ch. 1, pg. 24) A grammar can be regarded as a theory of a language; it is descriptively adequate to the extent that it correctly describes the intrinsic competence of the idealized native speaker. Another way Chomsky moves the goalposts is by distinguishing E-languages, like English and Spanish and Japanese, from I-languages, which only exist inside human minds. He claims that serious linguistics should be primarily interested in the latter. In a semi-technical book summarizing Chomsky’s theory of language, Cook and Newson write: (Chomsky’s Universal Grammar: An Introduction, pg. 13) E-language linguistics … aims to collect samples of language and then describe their properties. … I-language linguistics, however, is concerned with what a speaker knows about language and where this knowledge comes from; it treats language as an internal property of the human mind rather than something external … Not only should linguistics primarily be interested in studying I-languages, but to try and study E-languages at all may be a fool’s errand: (Chomsky’s Universal Grammar: An Introduction, pg. 13) Chomsky claims that the history of generative linguistics shows a shift from an E-language to an I-language approach; ‘the shift of focus from the dubious concept of E-language to the significant notion of I-language was a crucial step in early generative grammar’ (Chomsky, 1991b, pg. 10). … Indeed Chomsky is extremely dismissive of E-language approaches: ‘E-language, if it exists at all, is derivative, remote from mechanisms and of no particular empirical significance, perhaps none at all’ (Chomsky, 1991b, pg. 10).1 I Am Not A Linguist (IANAL), but this redefinition of the primary concern of linguistics seems crazy to me. Is studying a language like English as it is actually used really of no particular empirical significance? And this doesn’t seem to be a one-time hyperbole, but a representative claim. Cook and Newson continue: (Chomsky’s Universal Grammar: An Introduction, pg. 14) The opposition between these two approaches in linguistics has been long and acrimonious, neither side conceding the other’s reality. … The E-linguist despises the I-linguist for not looking at the ‘real’ facts; the I-linguist derides the E-linguist for looking at trivia. The I-language versus E-language distinction is as much a difference of research methods and of admissible evidence as it is of long-term goals. So much for what linguists ought to study. How should they study it? The previous quote gives us a clue. Especially in the era before Chomsky (BC), linguists were more interested in description. Linguists were, at least in one view, people who could be dropped anywhere in the world, and emerge with a tentative grammar of the local language six months later. (A notion like this is mentioned early in this video.) Linguists catalog the myriad of strange details about human languages, like the fact that some languages don’t appear to have words for relative directions, or “thank you”, or “yes” and “no”. After Chomsky's domination of the field (AD), there were a lot more theorists. While you could study language by going out into the field and collecting data, this was viewed as not the only, and maybe not even the most important, way to work. Diagrams of sentences proliferated. Chomsky, arguably the most influential linguist of the past hundred years, has never done fieldwork. In summary, to Chomsky and many of the linguists working in his tradition, the scientifically interesting component of language is grammar competence, and real linguistic data only indirectly reflects it. All of this matters because the dominance of Chomskyan linguistics has had downstream effects in adjacent fields like artificial intelligence (AI), evolutionary biology, and neuroscience. Chomsky has long been an opponent of the statistical learning tradition of language modeling, essentially claiming that it does not provide insight about what humans know about languages, and that engineering success probably can’t be achieved without explicitly incorporating important mathematical facts about the underlying structure of language. Chomsky’s ideas have motivated researchers to look for a “language gene” and “language areas” of the brain. Arguably, no one has yet found either—but more on that later. How Chomsky attained this stranglehold on linguistics is an interesting sociological question, but not our main concern in the present work2. The intent here is not to pooh-pooh Chomsky, either; brilliant and hard-working people are often wrong on important questions. Consider that his academic career began in the early 1950s—over 70 years ago!—when our understanding of language, anthropology, biology, neuroscience, and artificial intelligence, among many other things, was substantially more rudimentary. Where are we going with this? All of this is context for understanding the ideas of a certain bomb-throwing terrorist blight on the face of linguistics: Daniel Everett. How Language Began is a book he wrote about, well, what language is and how it began. Everett is the anti-Chomsky. II. THE MISSIONARY We all love classic boy-meets-girl stories. Here’s one: boy meets girl at a rock concert, they fall in love, the boy converts to Christianity for the girl, then the boy and girl move to the Amazon jungle to dedicate the rest of their lives to saving the souls of an isolated hunter-gatherer tribe. Daniel Everett is the boy in this story. The woman he married, Keren Graham, is the daughter of Christian missionaries and had formative experiences living in the Amazon jungle among the Sateré-Mawé people. At seventeen, Everett became a born-again Christian; at eighteen, he and Keren married; and over the next few years, they started a family and prepared to become full-fledged missionaries like Keren’s parents. First, Everett studied “Bible and Foreign Missions” at the Moody Bible Institute in Chicago. After finishing his degree in 1975, the natural next step was to train more specifically to follow in the footsteps of Keren’s parents. In 1976, he and his wife enrolled in the Summer Institute of Linguistics (SIL) to learn translation techniques and more viscerally prepare for life in the jungle: They were sent to Chiapas, Mexico, where Keren stayed in a hut in the jungle with the couple’s children—by this time, there were three—while Everett underwent grueling field training. He endured fifty-mile hikes and survived for several days deep in the jungle with only matches, water, a rope, a machete, and a flashlight. Everett apparently had a gift for language-learning. This led SIL to invite Everett and his wife to work with the Pirahã people (pronounced pee-da-HAN), whose unusual language had thwarted all previous attempts to learn it. In 1977, Everett’s family moved to Brazil, and in December they met the Pirahã for the first time. As an SIL-affiliated missionary, Everett’s explicit goals were to (i) translate the Bible into Pirahã, and (ii) convert as many Pirahã as possible to Christianity. But Everett’s first encounter with the Pirahã was cut short for political reasons: (Don’t Sleep There Are Snakes, Ch. 1, pg. 13-14) In December of 1977 the Brazilian government ordered all missionaries to leave Indian reservations. … Leaving the village under these forced circumstances made me wonder whether I’d ever be able to return. The Summer Institute of Linguistics was concerned too and wanted to find a way around the government’s prohibition against missionaries. So SIL asked me to apply to the graduate linguistics program at the State University of Campinas (UNICAMP), in the state of São Paulo, Brazil. It was hoped that UNICAMP would be able to secure government authorization for me to visit the Pirahãs for a prolonged period, in spite of the general ban against missionaries. … My work at UNICAMP paid off as SIL hoped it would. Everett became a linguist proper sort of by accident, mostly as an excuse to continue his missionary work. But he ended up developing a passion for it. In 1980, he completed Aspects of the Phonology of Pirahã, his master’s thesis. He continued on to get a PhD in linguistics, also from UNICAMP, and in 1983 finished The Pirahã Language and Theory of Syntax, his dissertation. He continued studying the Pirahã and working as an academic linguist after that. In all, Everett spent around ten years of his life living with the Pirahã, spread out over some thirty-odd years. As he notes in Don’t Sleep, There Are Snakes: (Prologue, pg. xvii-xviii) I went to the Pirahãs when I was twenty-six years old. Now I am old enough to receive senior discounts. I gave them my youth. I have contracted malaria many times. I remember several occasions on which the Pirahãs or others threatened my life. I have carried more heavy boxes, bags, and barrels on my back through the jungle than I care to remember. But my grandchildren all know the Pirahãs. My children are who they are in part because of the Pirahãs. And I can look at some of those old men (old like me) who once threatened to kill me and recognize some of the dearest friends I have ever had—men who would now risk their lives for me. Everett interviewing some Pirahã people. (source) Everett did eventually learn their language, and it’s worth taking a step back to appreciate just how hard that task was. No Pirahã spoke Portuguese, apart from some isolated phrases they used for bartering. They didn’t speak any other language at all—just Pirahã. How do you learn another group’s language when you have no languages in common? The technical term is monolingual fieldwork. But this is just a fancy label for some combination of pointing at things, listening, crude imitation, and obsessively transcribing whatever you hear. For years. It doesn’t help that the Pirahã language seems genuinely hard to learn in a few different senses. First, it is probably conventionally difficult for Westerners to learn since it is a tonal language (two tones: high and low) with a small number of phonemes (building block sounds) and a few unusual sounds3. Second, there is no written language. Third, the language has a variety of ‘channels of discourse’, or ways of talking specialized for one or another cultural context. One of these is ‘whistle speech’; Pirahãs can communicate purely in whistles. This feature appears to be extremely useful during hunting trips: (Don’t Sleep, There Are Snakes, Ch. 11, pg. 187-188) My first intense contact with whistle speech came one day when the Pirahãs had given me permission to go hunting with them. After we’d been walking for about an hour, they decided that they weren’t seeing any game because I, with my clunking canteens and machete and congenital clumsiness, was making too much noise. “You stay here and we will be back for you later.” Xaikáibaí said gently but firmly. … As I tried to make the best of my solitary confinement, I heard the men whistling to one another. They were saying, “I’ll go over there; you go that way,” and other such hunting talk. But clearly they were communicating. It was fascinating because it sounded so different from anything I had heard before. The whistle carried long and clear in the jungle. I could immediately see the importance and usefulness of this channel, which I guessed would also be much less likely to scare away game than the lower frequencies of the men’s normal voices. Fourth, important aspects of the language reflect core tenets of Pirahã culture in ways that one might not a priori expect. Everett writes extensively about the ‘immediacy of experience principle’ of Pirahã culture, which he summarizes as the idea that: (Don’t Sleep, There Are Snakes, Ch. 7, pg. 132) Declarative Pirahã utterances contain only assertions related directly to the moment of speech, either experienced by the speaker or witnessed by someone alive during the lifetime of the speaker. One way the language reflects this is that the speaker must specify how they know something by affixing an appropriate suffix to verbs: (Don’t Sleep, There Are Snakes, Ch. 12, pg. 196) Perhaps the most interesting suffixes, however (though these are not unique to Pirahã), are what linguists call evidentials, elements that represent the speaker’s evaluation of his or her knowledge of what he or she is saying. There are three of these in Pirahã: hearsay, observation, and deduction. To see what these do, let’s use an English example. If I ask you, “Did Joe go fishing?” you could answer, “Yes, at least I heard that he did,” or “Yes, I know because I saw him leave,” or “Yes, at least I suppose he did because his boat is gone.” The difference between English and Pirahã is that what English does with a sentence, Pirahã does with a verbal suffix. Everett also convincingly links this cultural principle to the lack of Pirahã number words and creation myths. On the latter topic, Everett recalls the following exchange: (Don’t Sleep, There Are Snakes, Ch. 7, pg. 134) I sat with Kóhoi once and he asked me, after hearing about my god, “What else does your god do?” And I answered, “Well, he made the stars, and he made the earth.” Then I asked, “What do the Pirahãs say?” He answered, “Well, the Pirahãs say that these things were not made.” And all of this is to say nothing of the manifold perils of the jungle: malaria, typhoid fever, dysentery, dangerous snakes, insects, morally gray river traders, and periodic downpours. If Indiana Jones braved these conditions for years, we would consider his stories rousing adventures. Everett did this while also learning one of the most unusual languages in the world. People on the bank of the Maici river. (source) By the way, he did eventually sort of achieve his goal of translating the Bible. Armed with a solid knowledge of Pirahã, he was able to translate the New Testament’s Gospel of Mark. Since the Pirahã have no written language, he provided them with a recorded version, but did not get the reaction he expected: (Don’t Sleep, There Are Snakes, Ch. 17, pg. 267-268) When we returned to the village, I recorded Mark’s gospel in my own voice for the Pirahãs to listen to. I then brought in a wind-up tape recorder to play the recording, and I taught the Pirahãs how to use it, which, surprisingly enough, some of the children did. Keren and I left the village and returned a few weeks later. The people were still listening to the gospel, with children cranking the recorder. I was initially quite excited about this, until it became clear that the only part of the book that they paid attention to was the beheading of John the Baptist. “Wow, they cut off his head. Play that again!” One reaction to hearing the gospel caught Everett even more off-guard: (Don’t Sleep, There Are Snakes, Ch. 17, pg. 269) "The women are afraid of Jesus. We do not want him." "Why not?" I asked, wondering what had triggered this declaration. "Because last night he came to our village and tried to have sex with our women. He chased them around the village, trying to stick his large penis into them." Kaaxaóoi proceeded to show me with his two hands held far apart how long Jesus's penis was—a good three feet. But the Pirahã had an even more serious objection to Jesus: (Don’t Sleep, There Are Snakes, Ch. 17, pg. 265-266) Part of the difficulty of my task began to become clear to me. I communicated more or less correctly to the Pirahãs about my Christian beliefs. The men listening to me understood that there was a man named Hisó, Jesus, and that he wanted others to do what he told them. "The Pirahã men then asked, "Hey Dan, what does Jesus look like? Is he dark like us or light like you?" I said, "Well, I have never actually seen him. He lived a long time ago. But I do have his words." "Well, Dan, how do you have his words if you have never heard him or seen him?" They then made it clear that if I had not actually seen this guy (and not in any metaphorical sense, but literally), they weren't interested in any stories I had to tell about him. Period. This is because, as I now knew, the Pirahãs believe only what they see. Sometimes they also believe in things that someone else has told them, so long as that person has personally witnessed what he or she is reporting. In the end, Everett never converted a single Pirahã. But he did even worse than converting zero people—he lost his own faith after coming to believe that the Pirahã had a good point. After keeping this to himself for many years, he revealed his loss of faith to his family, which led to a divorce and his children breaking contact with him for a number of years afterward. But Everett losing his faith in the God of Abraham was only the beginning. Most importantly for us, he also lost his faith in the God of Linguistics—Noam Chomsky. III. THE WAR In 2005, Everett’s paper “Cultural constraints on grammar and cognition in Pirahã: Another look at the design features of human language” was published in the journal Cultural Anthropology. An outsider might expect an article like this, which made a technical observation about the apparent lack of a property called ‘recursion’ in the Pirahã language, to receive an ‘oh, neat’ sort of response. Languages can be pretty different from one another, after all. Mandarin lacks plurals. Spanish sentences can omit an explicit subject. This is one of those kinds of things. But the article ignited a firestorm of controversy that follows Everett to this day. Praise for Everett and his work on recursion in Pirahã: He became a pure charlatan, although he used to be a good descriptive linguist. That is why, as far as I know, all the serious linguists who work on Brazilian languages ignore him. Noam Chomsky, MIT professor and linguist
Inline links: Wikipedia, hard takeoff, grammar, 1, this video, don’t appear to have words for relative directions, “thank you”, “yes” and “no”, long been an opponent, 2, Daniel Everett, Sateré-Mawé people, prepared, Bible and Foreign Missions, 1975, SIL, viscerally prepare, Pirahã people, https://substackcdn.com/image/fetch/$s_!42Ji!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F5c899185-e1a2-4358-ae6a-e9298f6c7cdb_1600x1002.jpeg, source, 3, number words, https://substackcdn.com/image/fetch/$s_!yx-R!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F77975f2c-ef0f-47d7-9ed9-f22bbe04f78b_1024x768.jpeg, source, Cultural constraints on grammar and cognition in Pirahã: Another look at the design features of human language
Everett interviewing some Pirahã people. (source) Everett did eventually learn their language, and it’s worth taking a step back to appreciate just how hard that task was. No Pirahã spoke Portuguese, apart from some isolated phrases they used for bartering. They didn’t speak any other language at all—just Pirahã. How do you learn another group’s language when you have no languages in common? The technical term is monolingual fieldwork. But this is just a fancy label for some combination of pointing at things, listening, crude imitation, and obsessively transcribing whatever you hear. For years. It doesn’t help that the Pirahã language seems genuinely hard to learn in a few different senses. First, it is probably conventionally difficult for Westerners to learn since it is a tonal language (two tones: high and low) with a small number of phonemes (building block sounds) and a few unusual sounds3. Second, there is no written language. Third, the language has a variety of ‘channels of discourse’, or ways of talking specialized for one or another cultural context. One of these is ‘whistle speech’; Pirahãs can communicate purely in whistles. This feature appears to be extremely useful during hunting trips: (Don’t Sleep, There Are Snakes, Ch. 11, pg. 187-188) My first intense contact with whistle speech came one day when the Pirahãs had given me permission to go hunting with them. After we’d been walking for about an hour, they decided that they weren’t seeing any game because I, with my clunking canteens and machete and congenital clumsiness, was making too much noise. “You stay here and we will be back for you later.” Xaikáibaí said gently but firmly. … As I tried to make the best of my solitary confinement, I heard the men whistling to one another. They were saying, “I’ll go over there; you go that way,” and other such hunting talk. But clearly they were communicating. It was fascinating because it sounded so different from anything I had heard before. The whistle carried long and clear in the jungle. I could immediately see the importance and usefulness of this channel, which I guessed would also be much less likely to scare away game than the lower frequencies of the men’s normal voices. Fourth, important aspects of the language reflect core tenets of Pirahã culture in ways that one might not a priori expect. Everett writes extensively about the ‘immediacy of experience principle’ of Pirahã culture, which he summarizes as the idea that: (Don’t Sleep, There Are Snakes, Ch. 7, pg. 132) Declarative Pirahã utterances contain only assertions related directly to the moment of speech, either experienced by the speaker or witnessed by someone alive during the lifetime of the speaker. One way the language reflects this is that the speaker must specify how they know something by affixing an appropriate suffix to verbs: (Don’t Sleep, There Are Snakes, Ch. 12, pg. 196) Perhaps the most interesting suffixes, however (though these are not unique to Pirahã), are what linguists call evidentials, elements that represent the speaker’s evaluation of his or her knowledge of what he or she is saying. There are three of these in Pirahã: hearsay, observation, and deduction. To see what these do, let’s use an English example. If I ask you, “Did Joe go fishing?” you could answer, “Yes, at least I heard that he did,” or “Yes, I know because I saw him leave,” or “Yes, at least I suppose he did because his boat is gone.” The difference between English and Pirahã is that what English does with a sentence, Pirahã does with a verbal suffix. Everett also convincingly links this cultural principle to the lack of Pirahã number words and creation myths. On the latter topic, Everett recalls the following exchange: (Don’t Sleep, There Are Snakes, Ch. 7, pg. 134) I sat with Kóhoi once and he asked me, after hearing about my god, “What else does your god do?” And I answered, “Well, he made the stars, and he made the earth.” Then I asked, “What do the Pirahãs say?” He answered, “Well, the Pirahãs say that these things were not made.” And all of this is to say nothing of the manifold perils of the jungle: malaria, typhoid fever, dysentery, dangerous snakes, insects, morally gray river traders, and periodic downpours. If Indiana Jones braved these conditions for years, we would consider his stories rousing adventures. Everett did this while also learning one of the most unusual languages in the world. People on the bank of the Maici river. (source) By the way, he did eventually sort of achieve his goal of translating the Bible. Armed with a solid knowledge of Pirahã, he was able to translate the New Testament’s Gospel of Mark. Since the Pirahã have no written language, he provided them with a recorded version, but did not get the reaction he expected: (Don’t Sleep, There Are Snakes, Ch. 17, pg. 267-268) When we returned to the village, I recorded Mark’s gospel in my own voice for the Pirahãs to listen to. I then brought in a wind-up tape recorder to play the recording, and I taught the Pirahãs how to use it, which, surprisingly enough, some of the children did. Keren and I left the village and returned a few weeks later. The people were still listening to the gospel, with children cranking the recorder. I was initially quite excited about this, until it became clear that the only part of the book that they paid attention to was the beheading of John the Baptist. “Wow, they cut off his head. Play that again!” One reaction to hearing the gospel caught Everett even more off-guard: (Don’t Sleep, There Are Snakes, Ch. 17, pg. 269) "The women are afraid of Jesus. We do not want him." "Why not?" I asked, wondering what had triggered this declaration. "Because last night he came to our village and tried to have sex with our women. He chased them around the village, trying to stick his large penis into them." Kaaxaóoi proceeded to show me with his two hands held far apart how long Jesus's penis was—a good three feet. But the Pirahã had an even more serious objection to Jesus: (Don’t Sleep, There Are Snakes, Ch. 17, pg. 265-266) Part of the difficulty of my task began to become clear to me. I communicated more or less correctly to the Pirahãs about my Christian beliefs. The men listening to me understood that there was a man named Hisó, Jesus, and that he wanted others to do what he told them. "The Pirahã men then asked, "Hey Dan, what does Jesus look like? Is he dark like us or light like you?" I said, "Well, I have never actually seen him. He lived a long time ago. But I do have his words." "Well, Dan, how do you have his words if you have never heard him or seen him?" They then made it clear that if I had not actually seen this guy (and not in any metaphorical sense, but literally), they weren't interested in any stories I had to tell about him. Period. This is because, as I now knew, the Pirahãs believe only what they see. Sometimes they also believe in things that someone else has told them, so long as that person has personally witnessed what he or she is reporting. In the end, Everett never converted a single Pirahã. But he did even worse than converting zero people—he lost his own faith after coming to believe that the Pirahã had a good point. After keeping this to himself for many years, he revealed his loss of faith to his family, which led to a divorce and his children breaking contact with him for a number of years afterward. But Everett losing his faith in the God of Abraham was only the beginning. Most importantly for us, he also lost his faith in the God of Linguistics—Noam Chomsky. III. THE WAR In 2005, Everett’s paper “Cultural constraints on grammar and cognition in Pirahã: Another look at the design features of human language” was published in the journal Cultural Anthropology. An outsider might expect an article like this, which made a technical observation about the apparent lack of a property called ‘recursion’ in the Pirahã language, to receive an ‘oh, neat’ sort of response. Languages can be pretty different from one another, after all. Mandarin lacks plurals. Spanish sentences can omit an explicit subject. This is one of those kinds of things. But the article ignited a firestorm of controversy that follows Everett to this day. Praise for Everett and his work on recursion in Pirahã: He became a pure charlatan, although he used to be a good descriptive linguist. That is why, as far as I know, all the serious linguists who work on Brazilian languages ignore him. Noam Chomsky, MIT professor and linguist
Inline links: source, monolingual fieldwork, 3, number words, https://substackcdn.com/image/fetch/$s_!yx-R!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F77975f2c-ef0f-47d7-9ed9-f22bbe04f78b_1024x768.jpeg, source, Cultural constraints on grammar and cognition in Pirahã: Another look at the design features of human language
People on the bank of the Maici river. (source) By the way, he did eventually sort of achieve his goal of translating the Bible. Armed with a solid knowledge of Pirahã, he was able to translate the New Testament’s Gospel of Mark. Since the Pirahã have no written language, he provided them with a recorded version, but did not get the reaction he expected: (Don’t Sleep, There Are Snakes, Ch. 17, pg. 267-268) When we returned to the village, I recorded Mark’s gospel in my own voice for the Pirahãs to listen to. I then brought in a wind-up tape recorder to play the recording, and I taught the Pirahãs how to use it, which, surprisingly enough, some of the children did. Keren and I left the village and returned a few weeks later. The people were still listening to the gospel, with children cranking the recorder. I was initially quite excited about this, until it became clear that the only part of the book that they paid attention to was the beheading of John the Baptist. “Wow, they cut off his head. Play that again!” One reaction to hearing the gospel caught Everett even more off-guard: (Don’t Sleep, There Are Snakes, Ch. 17, pg. 269) "The women are afraid of Jesus. We do not want him." "Why not?" I asked, wondering what had triggered this declaration. "Because last night he came to our village and tried to have sex with our women. He chased them around the village, trying to stick his large penis into them." Kaaxaóoi proceeded to show me with his two hands held far apart how long Jesus's penis was—a good three feet. But the Pirahã had an even more serious objection to Jesus: (Don’t Sleep, There Are Snakes, Ch. 17, pg. 265-266) Part of the difficulty of my task began to become clear to me. I communicated more or less correctly to the Pirahãs about my Christian beliefs. The men listening to me understood that there was a man named Hisó, Jesus, and that he wanted others to do what he told them. "The Pirahã men then asked, "Hey Dan, what does Jesus look like? Is he dark like us or light like you?" I said, "Well, I have never actually seen him. He lived a long time ago. But I do have his words." "Well, Dan, how do you have his words if you have never heard him or seen him?" They then made it clear that if I had not actually seen this guy (and not in any metaphorical sense, but literally), they weren't interested in any stories I had to tell about him. Period. This is because, as I now knew, the Pirahãs believe only what they see. Sometimes they also believe in things that someone else has told them, so long as that person has personally witnessed what he or she is reporting. In the end, Everett never converted a single Pirahã. But he did even worse than converting zero people—he lost his own faith after coming to believe that the Pirahã had a good point. After keeping this to himself for many years, he revealed his loss of faith to his family, which led to a divorce and his children breaking contact with him for a number of years afterward. But Everett losing his faith in the God of Abraham was only the beginning. Most importantly for us, he also lost his faith in the God of Linguistics—Noam Chomsky. III. THE WAR In 2005, Everett’s paper “Cultural constraints on grammar and cognition in Pirahã: Another look at the design features of human language” was published in the journal Cultural Anthropology. An outsider might expect an article like this, which made a technical observation about the apparent lack of a property called ‘recursion’ in the Pirahã language, to receive an ‘oh, neat’ sort of response. Languages can be pretty different from one another, after all. Mandarin lacks plurals. Spanish sentences can omit an explicit subject. This is one of those kinds of things. But the article ignited a firestorm of controversy that follows Everett to this day. Praise for Everett and his work on recursion in Pirahã: He became a pure charlatan, although he used to be a good descriptive linguist. That is why, as far as I know, all the serious linguists who work on Brazilian languages ignore him. Noam Chomsky, MIT professor and linguist
Inline links: source, Cultural constraints on grammar and cognition in Pirahã: Another look at the design features of human language
Pirahã language1 mentions across 1 issues

Pirahã language is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between July 19, 2024 and July 19, 2024. The archive places it in contexts such as "Pirahã language seems genuinely hard to learn". It most often appears alongside Alan Turing, Amazon, Amazon jungle.

Reference entry
Pirahã language
Mention count
1
Issue count
1
First seen
July 19, 2024
Last seen
July 19, 2024
Outbound links
Issue trail
Related pages
Source context
Your Book Review: How Language Began
July 19, 2024 · Original source
This is what he looks like. According to Wikipedia, the context for this picture is: “Noam Chomsky speaks about humanity's prospects for survival” Since around 1957, Chomsky has dominated linguistics. And this matters because he is kind of a contrarian with weird ideas. Is language for communicating? No, it’s mainly for thinking: (What Kind of Creatures Are We? Ch. 1, pg. 15-16) It is, indeed, virtual dogma that the function of language is communication. ... there is by now quite significant evidence that it is simply false. Doubtless language is sometimes used for communication, as is style of dress, facial expression and stance, and much else. But fundamental properties of language design indicate that a rich tradition is correct in regarding language as essentially an instrument of thought, even if we do not go as far as Humboldt in identifying the two. Should linguists care about the interaction between culture and language? No, that’s essentially stamp-collecting: (Language and Responsibility, Ch. 2, pg. 56-57) Again, a discipline is defined in terms of its object and its results. Sociology is the study of society. As to its results, it seems that there are few things one can say about that, at least at a fairly general level. One finds observations, intuitions, impressions, some valid generalizations perhaps. All very valuable, no doubt, but not at the level of explanatory principles. … Sociolinguistics is, I suppose, a discipline that seeks to apply principles of sociology to the study of language; but I suspect that it can draw little from sociology, and I wonder whether it is likely to contribute much to it. … You can also collect butterflies and make many observations. If you like butterflies, that’s fine; but such work must not be confounded with research, which is concerned to discover explanatory principles of some depth and fails if it has not done so. Did the human capacity for language evolve gradually? No, it suddenly appeared around 50,000 years ago after a freak gene mutation: (Language and Mind, third edition, pg, 183-184) An elementary fact about the language faculty is that it is a system of discrete infinity, rare in the organic world. Any such system is based on a primitive operation that takes objects already constructed, and constructs from them a new object: in the simplest case, the set containing them. Call that operation Merge. Either Merge or some equivalent is a minimal requirement. With Merge available, we instantly have an unbounded system of hierarchically structured expressions. The simplest account of the “Great Leap Forward” in the evolution of humans would be that the brain was rewired, perhaps by some slight mutation, to provide the operation Merge … There are speculations about the evolution of language that postulate a far more complex process … A more parsimonious speculation is that they did not, and that the Great Leap was effectively instantaneous, in a single individual, who was instantly endowed with intellectual capacities far superior to those of others, transmitted to offspring and coming to predominate. At best a reasonable guess, as are all speculations about such matters, but about the simplest one imaginable, and not inconsistent with anything known or plausibly surmised. It is hard to see what account of human evolution would not assume at least this much, in one or another form. I think all of these positions are kind of insane for reasons that we will discuss later. (Side note: Chomsky’s proposal is essentially the hard takeoff theory of human intelligence.) Most consequential of all, perhaps, are the ways Chomsky has influenced (i) what linguists mainly study, and (ii) how they go about studying it. Naively, since language involves many different components—including sound production and comprehension, intonation, gestures, and context, among many others—linguists might want to study all of these. While they do study all of these, Chomsky and his followers view grammar as by far the most important component of humans’ ability to understand and produce language, and accordingly make it their central focus. Roughly speaking, grammar refers to the set of language-specific rules that determine whether a sentence is well-formed. It goes beyond specifying word order (or ‘surface structure’, in Chomskyan terminology) since one needs to know more than just where words are placed in order to modify or extend a given sentence. Consider a pair of sentences Chomsky uses to illustrate this point in Aspects of the Theory of Syntax (pg. 22), his most cited work: (1a) I expected John to be examined by a specialist. (2a) I persuaded John to be examined by a specialist. The words “expected” and “persuaded” appear in the same location in each sentence, but imply different ‘latent’ grammatical structures, or ‘deep structures’. One way to show this is to observe that a particular way of rearranging the words produces a sentence with the same meaning in the first case (1a = 1b), and a different meaning in the second (2a != 2b): (1b) I expected a specialist to examine John. (2b) I persuaded a specialist to examine John. In particular, the target of persuasion is “John” in the case of (2a), and “the specialist” in the case of (2b). A full Chomskyan treatment of sentences like this would involve hierarchical tree diagrams, which permit a precise description of deep structure. You may have encountered the famous sentence: “Colorless green ideas sleep furiously.” It first appeared in Chomsky’s 1957 book Syntactic Structures, and the point is that even nonsense sentences can be grammatically well-formed, and that speakers can quickly assess the grammatical correctness of even nonsense sentences that they’ve never seen before. To Chomsky, this is one of the most important facts to be explained about language. A naive response to Chomsky’s preoccupation with grammar is: doesn’t real language involve a lot of non-grammatical stuff, like stuttering and slips of the tongue and midstream changes of mind? Of course it does, and Chomsky acknowledges this. To address this point, Chomsky has to move the goalposts in two important ways. First, he famously distinguishes competence from performance, and identifies the former as the subject of any serious theory of language: (Aspects of the Theory of Syntax, Ch. 1, pg. 4) The problem for the linguist, as well as for the child learning the language, is to determine from the data of performance the underlying system of rules that has been mastered by the speaker-hearer and that he puts to use in actual performance. Hence, in the technical sense, linguistic theory is mentalistic, since it is concerned with discovering a mental reality underlying actual behavior. Observed use of language or hypothesized dispositions to respond, habits, and so on, may provide evidence as to the nature of this mental reality, but surely cannot constitute the actual subject matter of linguistics, if this is to be a serious discipline. Moreover, he claims that grammar captures most of what we should mean when we talk about speakers’ linguistic competence: (Aspects of the Theory of Syntax, Ch. 1, pg. 24) A grammar can be regarded as a theory of a language; it is descriptively adequate to the extent that it correctly describes the intrinsic competence of the idealized native speaker. Another way Chomsky moves the goalposts is by distinguishing E-languages, like English and Spanish and Japanese, from I-languages, which only exist inside human minds. He claims that serious linguistics should be primarily interested in the latter. In a semi-technical book summarizing Chomsky’s theory of language, Cook and Newson write: (Chomsky’s Universal Grammar: An Introduction, pg. 13) E-language linguistics … aims to collect samples of language and then describe their properties. … I-language linguistics, however, is concerned with what a speaker knows about language and where this knowledge comes from; it treats language as an internal property of the human mind rather than something external … Not only should linguistics primarily be interested in studying I-languages, but to try and study E-languages at all may be a fool’s errand: (Chomsky’s Universal Grammar: An Introduction, pg. 13) Chomsky claims that the history of generative linguistics shows a shift from an E-language to an I-language approach; ‘the shift of focus from the dubious concept of E-language to the significant notion of I-language was a crucial step in early generative grammar’ (Chomsky, 1991b, pg. 10). … Indeed Chomsky is extremely dismissive of E-language approaches: ‘E-language, if it exists at all, is derivative, remote from mechanisms and of no particular empirical significance, perhaps none at all’ (Chomsky, 1991b, pg. 10).1 I Am Not A Linguist (IANAL), but this redefinition of the primary concern of linguistics seems crazy to me. Is studying a language like English as it is actually used really of no particular empirical significance? And this doesn’t seem to be a one-time hyperbole, but a representative claim. Cook and Newson continue: (Chomsky’s Universal Grammar: An Introduction, pg. 14) The opposition between these two approaches in linguistics has been long and acrimonious, neither side conceding the other’s reality. … The E-linguist despises the I-linguist for not looking at the ‘real’ facts; the I-linguist derides the E-linguist for looking at trivia. The I-language versus E-language distinction is as much a difference of research methods and of admissible evidence as it is of long-term goals. So much for what linguists ought to study. How should they study it? The previous quote gives us a clue. Especially in the era before Chomsky (BC), linguists were more interested in description. Linguists were, at least in one view, people who could be dropped anywhere in the world, and emerge with a tentative grammar of the local language six months later. (A notion like this is mentioned early in this video.) Linguists catalog the myriad of strange details about human languages, like the fact that some languages don’t appear to have words for relative directions, or “thank you”, or “yes” and “no”. After Chomsky's domination of the field (AD), there were a lot more theorists. While you could study language by going out into the field and collecting data, this was viewed as not the only, and maybe not even the most important, way to work. Diagrams of sentences proliferated. Chomsky, arguably the most influential linguist of the past hundred years, has never done fieldwork. In summary, to Chomsky and many of the linguists working in his tradition, the scientifically interesting component of language is grammar competence, and real linguistic data only indirectly reflects it. All of this matters because the dominance of Chomskyan linguistics has had downstream effects in adjacent fields like artificial intelligence (AI), evolutionary biology, and neuroscience. Chomsky has long been an opponent of the statistical learning tradition of language modeling, essentially claiming that it does not provide insight about what humans know about languages, and that engineering success probably can’t be achieved without explicitly incorporating important mathematical facts about the underlying structure of language. Chomsky’s ideas have motivated researchers to look for a “language gene” and “language areas” of the brain. Arguably, no one has yet found either—but more on that later. How Chomsky attained this stranglehold on linguistics is an interesting sociological question, but not our main concern in the present work2. The intent here is not to pooh-pooh Chomsky, either; brilliant and hard-working people are often wrong on important questions. Consider that his academic career began in the early 1950s—over 70 years ago!—when our understanding of language, anthropology, biology, neuroscience, and artificial intelligence, among many other things, was substantially more rudimentary. Where are we going with this? All of this is context for understanding the ideas of a certain bomb-throwing terrorist blight on the face of linguistics: Daniel Everett. How Language Began is a book he wrote about, well, what language is and how it began. Everett is the anti-Chomsky. II. THE MISSIONARY We all love classic boy-meets-girl stories. Here’s one: boy meets girl at a rock concert, they fall in love, the boy converts to Christianity for the girl, then the boy and girl move to the Amazon jungle to dedicate the rest of their lives to saving the souls of an isolated hunter-gatherer tribe. Daniel Everett is the boy in this story. The woman he married, Keren Graham, is the daughter of Christian missionaries and had formative experiences living in the Amazon jungle among the Sateré-Mawé people. At seventeen, Everett became a born-again Christian; at eighteen, he and Keren married; and over the next few years, they started a family and prepared to become full-fledged missionaries like Keren’s parents. First, Everett studied “Bible and Foreign Missions” at the Moody Bible Institute in Chicago. After finishing his degree in 1975, the natural next step was to train more specifically to follow in the footsteps of Keren’s parents. In 1976, he and his wife enrolled in the Summer Institute of Linguistics (SIL) to learn translation techniques and more viscerally prepare for life in the jungle: They were sent to Chiapas, Mexico, where Keren stayed in a hut in the jungle with the couple’s children—by this time, there were three—while Everett underwent grueling field training. He endured fifty-mile hikes and survived for several days deep in the jungle with only matches, water, a rope, a machete, and a flashlight. Everett apparently had a gift for language-learning. This led SIL to invite Everett and his wife to work with the Pirahã people (pronounced pee-da-HAN), whose unusual language had thwarted all previous attempts to learn it. In 1977, Everett’s family moved to Brazil, and in December they met the Pirahã for the first time. As an SIL-affiliated missionary, Everett’s explicit goals were to (i) translate the Bible into Pirahã, and (ii) convert as many Pirahã as possible to Christianity. But Everett’s first encounter with the Pirahã was cut short for political reasons: (Don’t Sleep There Are Snakes, Ch. 1, pg. 13-14) In December of 1977 the Brazilian government ordered all missionaries to leave Indian reservations. … Leaving the village under these forced circumstances made me wonder whether I’d ever be able to return. The Summer Institute of Linguistics was concerned too and wanted to find a way around the government’s prohibition against missionaries. So SIL asked me to apply to the graduate linguistics program at the State University of Campinas (UNICAMP), in the state of São Paulo, Brazil. It was hoped that UNICAMP would be able to secure government authorization for me to visit the Pirahãs for a prolonged period, in spite of the general ban against missionaries. … My work at UNICAMP paid off as SIL hoped it would. Everett became a linguist proper sort of by accident, mostly as an excuse to continue his missionary work. But he ended up developing a passion for it. In 1980, he completed Aspects of the Phonology of Pirahã, his master’s thesis. He continued on to get a PhD in linguistics, also from UNICAMP, and in 1983 finished The Pirahã Language and Theory of Syntax, his dissertation. He continued studying the Pirahã and working as an academic linguist after that. In all, Everett spent around ten years of his life living with the Pirahã, spread out over some thirty-odd years. As he notes in Don’t Sleep, There Are Snakes: (Prologue, pg. xvii-xviii) I went to the Pirahãs when I was twenty-six years old. Now I am old enough to receive senior discounts. I gave them my youth. I have contracted malaria many times. I remember several occasions on which the Pirahãs or others threatened my life. I have carried more heavy boxes, bags, and barrels on my back through the jungle than I care to remember. But my grandchildren all know the Pirahãs. My children are who they are in part because of the Pirahãs. And I can look at some of those old men (old like me) who once threatened to kill me and recognize some of the dearest friends I have ever had—men who would now risk their lives for me. Everett interviewing some Pirahã people. (source) Everett did eventually learn their language, and it’s worth taking a step back to appreciate just how hard that task was. No Pirahã spoke Portuguese, apart from some isolated phrases they used for bartering. They didn’t speak any other language at all—just Pirahã. How do you learn another group’s language when you have no languages in common? The technical term is monolingual fieldwork. But this is just a fancy label for some combination of pointing at things, listening, crude imitation, and obsessively transcribing whatever you hear. For years. It doesn’t help that the Pirahã language seems genuinely hard to learn in a few different senses. First, it is probably conventionally difficult for Westerners to learn since it is a tonal language (two tones: high and low) with a small number of phonemes (building block sounds) and a few unusual sounds3. Second, there is no written language. Third, the language has a variety of ‘channels of discourse’, or ways of talking specialized for one or another cultural context. One of these is ‘whistle speech’; Pirahãs can communicate purely in whistles. This feature appears to be extremely useful during hunting trips: (Don’t Sleep, There Are Snakes, Ch. 11, pg. 187-188) My first intense contact with whistle speech came one day when the Pirahãs had given me permission to go hunting with them. After we’d been walking for about an hour, they decided that they weren’t seeing any game because I, with my clunking canteens and machete and congenital clumsiness, was making too much noise. “You stay here and we will be back for you later.” Xaikáibaí said gently but firmly. … As I tried to make the best of my solitary confinement, I heard the men whistling to one another. They were saying, “I’ll go over there; you go that way,” and other such hunting talk. But clearly they were communicating. It was fascinating because it sounded so different from anything I had heard before. The whistle carried long and clear in the jungle. I could immediately see the importance and usefulness of this channel, which I guessed would also be much less likely to scare away game than the lower frequencies of the men’s normal voices. Fourth, important aspects of the language reflect core tenets of Pirahã culture in ways that one might not a priori expect. Everett writes extensively about the ‘immediacy of experience principle’ of Pirahã culture, which he summarizes as the idea that: (Don’t Sleep, There Are Snakes, Ch. 7, pg. 132) Declarative Pirahã utterances contain only assertions related directly to the moment of speech, either experienced by the speaker or witnessed by someone alive during the lifetime of the speaker. One way the language reflects this is that the speaker must specify how they know something by affixing an appropriate suffix to verbs: (Don’t Sleep, There Are Snakes, Ch. 12, pg. 196) Perhaps the most interesting suffixes, however (though these are not unique to Pirahã), are what linguists call evidentials, elements that represent the speaker’s evaluation of his or her knowledge of what he or she is saying. There are three of these in Pirahã: hearsay, observation, and deduction. To see what these do, let’s use an English example. If I ask you, “Did Joe go fishing?” you could answer, “Yes, at least I heard that he did,” or “Yes, I know because I saw him leave,” or “Yes, at least I suppose he did because his boat is gone.” The difference between English and Pirahã is that what English does with a sentence, Pirahã does with a verbal suffix. Everett also convincingly links this cultural principle to the lack of Pirahã number words and creation myths. On the latter topic, Everett recalls the following exchange: (Don’t Sleep, There Are Snakes, Ch. 7, pg. 134) I sat with Kóhoi once and he asked me, after hearing about my god, “What else does your god do?” And I answered, “Well, he made the stars, and he made the earth.” Then I asked, “What do the Pirahãs say?” He answered, “Well, the Pirahãs say that these things were not made.” And all of this is to say nothing of the manifold perils of the jungle: malaria, typhoid fever, dysentery, dangerous snakes, insects, morally gray river traders, and periodic downpours. If Indiana Jones braved these conditions for years, we would consider his stories rousing adventures. Everett did this while also learning one of the most unusual languages in the world. People on the bank of the Maici river. (source) By the way, he did eventually sort of achieve his goal of translating the Bible. Armed with a solid knowledge of Pirahã, he was able to translate the New Testament’s Gospel of Mark. Since the Pirahã have no written language, he provided them with a recorded version, but did not get the reaction he expected: (Don’t Sleep, There Are Snakes, Ch. 17, pg. 267-268) When we returned to the village, I recorded Mark’s gospel in my own voice for the Pirahãs to listen to. I then brought in a wind-up tape recorder to play the recording, and I taught the Pirahãs how to use it, which, surprisingly enough, some of the children did. Keren and I left the village and returned a few weeks later. The people were still listening to the gospel, with children cranking the recorder. I was initially quite excited about this, until it became clear that the only part of the book that they paid attention to was the beheading of John the Baptist. “Wow, they cut off his head. Play that again!” One reaction to hearing the gospel caught Everett even more off-guard: (Don’t Sleep, There Are Snakes, Ch. 17, pg. 269) "The women are afraid of Jesus. We do not want him." "Why not?" I asked, wondering what had triggered this declaration. "Because last night he came to our village and tried to have sex with our women. He chased them around the village, trying to stick his large penis into them." Kaaxaóoi proceeded to show me with his two hands held far apart how long Jesus's penis was—a good three feet. But the Pirahã had an even more serious objection to Jesus: (Don’t Sleep, There Are Snakes, Ch. 17, pg. 265-266) Part of the difficulty of my task began to become clear to me. I communicated more or less correctly to the Pirahãs about my Christian beliefs. The men listening to me understood that there was a man named Hisó, Jesus, and that he wanted others to do what he told them. "The Pirahã men then asked, "Hey Dan, what does Jesus look like? Is he dark like us or light like you?" I said, "Well, I have never actually seen him. He lived a long time ago. But I do have his words." "Well, Dan, how do you have his words if you have never heard him or seen him?" They then made it clear that if I had not actually seen this guy (and not in any metaphorical sense, but literally), they weren't interested in any stories I had to tell about him. Period. This is because, as I now knew, the Pirahãs believe only what they see. Sometimes they also believe in things that someone else has told them, so long as that person has personally witnessed what he or she is reporting. In the end, Everett never converted a single Pirahã. But he did even worse than converting zero people—he lost his own faith after coming to believe that the Pirahã had a good point. After keeping this to himself for many years, he revealed his loss of faith to his family, which led to a divorce and his children breaking contact with him for a number of years afterward. But Everett losing his faith in the God of Abraham was only the beginning. Most importantly for us, he also lost his faith in the God of Linguistics—Noam Chomsky. III. THE WAR In 2005, Everett’s paper “Cultural constraints on grammar and cognition in Pirahã: Another look at the design features of human language” was published in the journal Cultural Anthropology. An outsider might expect an article like this, which made a technical observation about the apparent lack of a property called ‘recursion’ in the Pirahã language, to receive an ‘oh, neat’ sort of response. Languages can be pretty different from one another, after all. Mandarin lacks plurals. Spanish sentences can omit an explicit subject. This is one of those kinds of things. But the article ignited a firestorm of controversy that follows Everett to this day. Praise for Everett and his work on recursion in Pirahã: He became a pure charlatan, although he used to be a good descriptive linguist. That is why, as far as I know, all the serious linguists who work on Brazilian languages ignore him. Noam Chomsky, MIT professor and linguist
Inline links: Wikipedia, hard takeoff, grammar, 1, this video, don’t appear to have words for relative directions, “thank you”, “yes” and “no”, long been an opponent, 2, Daniel Everett, Sateré-Mawé people, prepared, Bible and Foreign Missions, 1975, SIL, viscerally prepare, Pirahã people, https://substackcdn.com/image/fetch/$s_!42Ji!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F5c899185-e1a2-4358-ae6a-e9298f6c7cdb_1600x1002.jpeg, source, 3, number words, https://substackcdn.com/image/fetch/$s_!yx-R!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F77975f2c-ef0f-47d7-9ed9-f22bbe04f78b_1024x768.jpeg, source, Cultural constraints on grammar and cognition in Pirahã: Another look at the design features of human language
Everett interviewing some Pirahã people. (source) Everett did eventually learn their language, and it’s worth taking a step back to appreciate just how hard that task was. No Pirahã spoke Portuguese, apart from some isolated phrases they used for bartering. They didn’t speak any other language at all—just Pirahã. How do you learn another group’s language when you have no languages in common? The technical term is monolingual fieldwork. But this is just a fancy label for some combination of pointing at things, listening, crude imitation, and obsessively transcribing whatever you hear. For years. It doesn’t help that the Pirahã language seems genuinely hard to learn in a few different senses. First, it is probably conventionally difficult for Westerners to learn since it is a tonal language (two tones: high and low) with a small number of phonemes (building block sounds) and a few unusual sounds3. Second, there is no written language. Third, the language has a variety of ‘channels of discourse’, or ways of talking specialized for one or another cultural context. One of these is ‘whistle speech’; Pirahãs can communicate purely in whistles. This feature appears to be extremely useful during hunting trips: (Don’t Sleep, There Are Snakes, Ch. 11, pg. 187-188) My first intense contact with whistle speech came one day when the Pirahãs had given me permission to go hunting with them. After we’d been walking for about an hour, they decided that they weren’t seeing any game because I, with my clunking canteens and machete and congenital clumsiness, was making too much noise. “You stay here and we will be back for you later.” Xaikáibaí said gently but firmly. … As I tried to make the best of my solitary confinement, I heard the men whistling to one another. They were saying, “I’ll go over there; you go that way,” and other such hunting talk. But clearly they were communicating. It was fascinating because it sounded so different from anything I had heard before. The whistle carried long and clear in the jungle. I could immediately see the importance and usefulness of this channel, which I guessed would also be much less likely to scare away game than the lower frequencies of the men’s normal voices. Fourth, important aspects of the language reflect core tenets of Pirahã culture in ways that one might not a priori expect. Everett writes extensively about the ‘immediacy of experience principle’ of Pirahã culture, which he summarizes as the idea that: (Don’t Sleep, There Are Snakes, Ch. 7, pg. 132) Declarative Pirahã utterances contain only assertions related directly to the moment of speech, either experienced by the speaker or witnessed by someone alive during the lifetime of the speaker. One way the language reflects this is that the speaker must specify how they know something by affixing an appropriate suffix to verbs: (Don’t Sleep, There Are Snakes, Ch. 12, pg. 196) Perhaps the most interesting suffixes, however (though these are not unique to Pirahã), are what linguists call evidentials, elements that represent the speaker’s evaluation of his or her knowledge of what he or she is saying. There are three of these in Pirahã: hearsay, observation, and deduction. To see what these do, let’s use an English example. If I ask you, “Did Joe go fishing?” you could answer, “Yes, at least I heard that he did,” or “Yes, I know because I saw him leave,” or “Yes, at least I suppose he did because his boat is gone.” The difference between English and Pirahã is that what English does with a sentence, Pirahã does with a verbal suffix. Everett also convincingly links this cultural principle to the lack of Pirahã number words and creation myths. On the latter topic, Everett recalls the following exchange: (Don’t Sleep, There Are Snakes, Ch. 7, pg. 134) I sat with Kóhoi once and he asked me, after hearing about my god, “What else does your god do?” And I answered, “Well, he made the stars, and he made the earth.” Then I asked, “What do the Pirahãs say?” He answered, “Well, the Pirahãs say that these things were not made.” And all of this is to say nothing of the manifold perils of the jungle: malaria, typhoid fever, dysentery, dangerous snakes, insects, morally gray river traders, and periodic downpours. If Indiana Jones braved these conditions for years, we would consider his stories rousing adventures. Everett did this while also learning one of the most unusual languages in the world. People on the bank of the Maici river. (source) By the way, he did eventually sort of achieve his goal of translating the Bible. Armed with a solid knowledge of Pirahã, he was able to translate the New Testament’s Gospel of Mark. Since the Pirahã have no written language, he provided them with a recorded version, but did not get the reaction he expected: (Don’t Sleep, There Are Snakes, Ch. 17, pg. 267-268) When we returned to the village, I recorded Mark’s gospel in my own voice for the Pirahãs to listen to. I then brought in a wind-up tape recorder to play the recording, and I taught the Pirahãs how to use it, which, surprisingly enough, some of the children did. Keren and I left the village and returned a few weeks later. The people were still listening to the gospel, with children cranking the recorder. I was initially quite excited about this, until it became clear that the only part of the book that they paid attention to was the beheading of John the Baptist. “Wow, they cut off his head. Play that again!” One reaction to hearing the gospel caught Everett even more off-guard: (Don’t Sleep, There Are Snakes, Ch. 17, pg. 269) "The women are afraid of Jesus. We do not want him." "Why not?" I asked, wondering what had triggered this declaration. "Because last night he came to our village and tried to have sex with our women. He chased them around the village, trying to stick his large penis into them." Kaaxaóoi proceeded to show me with his two hands held far apart how long Jesus's penis was—a good three feet. But the Pirahã had an even more serious objection to Jesus: (Don’t Sleep, There Are Snakes, Ch. 17, pg. 265-266) Part of the difficulty of my task began to become clear to me. I communicated more or less correctly to the Pirahãs about my Christian beliefs. The men listening to me understood that there was a man named Hisó, Jesus, and that he wanted others to do what he told them. "The Pirahã men then asked, "Hey Dan, what does Jesus look like? Is he dark like us or light like you?" I said, "Well, I have never actually seen him. He lived a long time ago. But I do have his words." "Well, Dan, how do you have his words if you have never heard him or seen him?" They then made it clear that if I had not actually seen this guy (and not in any metaphorical sense, but literally), they weren't interested in any stories I had to tell about him. Period. This is because, as I now knew, the Pirahãs believe only what they see. Sometimes they also believe in things that someone else has told them, so long as that person has personally witnessed what he or she is reporting. In the end, Everett never converted a single Pirahã. But he did even worse than converting zero people—he lost his own faith after coming to believe that the Pirahã had a good point. After keeping this to himself for many years, he revealed his loss of faith to his family, which led to a divorce and his children breaking contact with him for a number of years afterward. But Everett losing his faith in the God of Abraham was only the beginning. Most importantly for us, he also lost his faith in the God of Linguistics—Noam Chomsky. III. THE WAR In 2005, Everett’s paper “Cultural constraints on grammar and cognition in Pirahã: Another look at the design features of human language” was published in the journal Cultural Anthropology. An outsider might expect an article like this, which made a technical observation about the apparent lack of a property called ‘recursion’ in the Pirahã language, to receive an ‘oh, neat’ sort of response. Languages can be pretty different from one another, after all. Mandarin lacks plurals. Spanish sentences can omit an explicit subject. This is one of those kinds of things. But the article ignited a firestorm of controversy that follows Everett to this day. Praise for Everett and his work on recursion in Pirahã: He became a pure charlatan, although he used to be a good descriptive linguist. That is why, as far as I know, all the serious linguists who work on Brazilian languages ignore him. Noam Chomsky, MIT professor and linguist
Inline links: source, monolingual fieldwork, 3, number words, https://substackcdn.com/image/fetch/$s_!yx-R!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F77975f2c-ef0f-47d7-9ed9-f22bbe04f78b_1024x768.jpeg, source, Cultural constraints on grammar and cognition in Pirahã: Another look at the design features of human language
People on the bank of the Maici river. (source) By the way, he did eventually sort of achieve his goal of translating the Bible. Armed with a solid knowledge of Pirahã, he was able to translate the New Testament’s Gospel of Mark. Since the Pirahã have no written language, he provided them with a recorded version, but did not get the reaction he expected: (Don’t Sleep, There Are Snakes, Ch. 17, pg. 267-268) When we returned to the village, I recorded Mark’s gospel in my own voice for the Pirahãs to listen to. I then brought in a wind-up tape recorder to play the recording, and I taught the Pirahãs how to use it, which, surprisingly enough, some of the children did. Keren and I left the village and returned a few weeks later. The people were still listening to the gospel, with children cranking the recorder. I was initially quite excited about this, until it became clear that the only part of the book that they paid attention to was the beheading of John the Baptist. “Wow, they cut off his head. Play that again!” One reaction to hearing the gospel caught Everett even more off-guard: (Don’t Sleep, There Are Snakes, Ch. 17, pg. 269) "The women are afraid of Jesus. We do not want him." "Why not?" I asked, wondering what had triggered this declaration. "Because last night he came to our village and tried to have sex with our women. He chased them around the village, trying to stick his large penis into them." Kaaxaóoi proceeded to show me with his two hands held far apart how long Jesus's penis was—a good three feet. But the Pirahã had an even more serious objection to Jesus: (Don’t Sleep, There Are Snakes, Ch. 17, pg. 265-266) Part of the difficulty of my task began to become clear to me. I communicated more or less correctly to the Pirahãs about my Christian beliefs. The men listening to me understood that there was a man named Hisó, Jesus, and that he wanted others to do what he told them. "The Pirahã men then asked, "Hey Dan, what does Jesus look like? Is he dark like us or light like you?" I said, "Well, I have never actually seen him. He lived a long time ago. But I do have his words." "Well, Dan, how do you have his words if you have never heard him or seen him?" They then made it clear that if I had not actually seen this guy (and not in any metaphorical sense, but literally), they weren't interested in any stories I had to tell about him. Period. This is because, as I now knew, the Pirahãs believe only what they see. Sometimes they also believe in things that someone else has told them, so long as that person has personally witnessed what he or she is reporting. In the end, Everett never converted a single Pirahã. But he did even worse than converting zero people—he lost his own faith after coming to believe that the Pirahã had a good point. After keeping this to himself for many years, he revealed his loss of faith to his family, which led to a divorce and his children breaking contact with him for a number of years afterward. But Everett losing his faith in the God of Abraham was only the beginning. Most importantly for us, he also lost his faith in the God of Linguistics—Noam Chomsky. III. THE WAR In 2005, Everett’s paper “Cultural constraints on grammar and cognition in Pirahã: Another look at the design features of human language” was published in the journal Cultural Anthropology. An outsider might expect an article like this, which made a technical observation about the apparent lack of a property called ‘recursion’ in the Pirahã language, to receive an ‘oh, neat’ sort of response. Languages can be pretty different from one another, after all. Mandarin lacks plurals. Spanish sentences can omit an explicit subject. This is one of those kinds of things. But the article ignited a firestorm of controversy that follows Everett to this day. Praise for Everett and his work on recursion in Pirahã: He became a pure charlatan, although he used to be a good descriptive linguist. That is why, as far as I know, all the serious linguists who work on Brazilian languages ignore him. Noam Chomsky, MIT professor and linguist
Inline links: source, Cultural constraints on grammar and cognition in Pirahã: Another look at the design features of human language
Pirahã people1 mentions across 1 issues

Pirahã people is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between July 19, 2024 and July 19, 2024. The archive places it in contexts such as "Everett and his wife to work with the Pirahã people". It most often appears alongside Alan Turing, Amazon, Amazon jungle.

Reference entry
Pirahã people
Mention count
1
Issue count
1
First seen
July 19, 2024
Last seen
July 19, 2024
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Your Book Review: How Language Began
July 19, 2024 · Original source
This is what he looks like. According to Wikipedia, the context for this picture is: “Noam Chomsky speaks about humanity's prospects for survival” Since around 1957, Chomsky has dominated linguistics. And this matters because he is kind of a contrarian with weird ideas. Is language for communicating? No, it’s mainly for thinking: (What Kind of Creatures Are We? Ch. 1, pg. 15-16) It is, indeed, virtual dogma that the function of language is communication. ... there is by now quite significant evidence that it is simply false. Doubtless language is sometimes used for communication, as is style of dress, facial expression and stance, and much else. But fundamental properties of language design indicate that a rich tradition is correct in regarding language as essentially an instrument of thought, even if we do not go as far as Humboldt in identifying the two. Should linguists care about the interaction between culture and language? No, that’s essentially stamp-collecting: (Language and Responsibility, Ch. 2, pg. 56-57) Again, a discipline is defined in terms of its object and its results. Sociology is the study of society. As to its results, it seems that there are few things one can say about that, at least at a fairly general level. One finds observations, intuitions, impressions, some valid generalizations perhaps. All very valuable, no doubt, but not at the level of explanatory principles. … Sociolinguistics is, I suppose, a discipline that seeks to apply principles of sociology to the study of language; but I suspect that it can draw little from sociology, and I wonder whether it is likely to contribute much to it. … You can also collect butterflies and make many observations. If you like butterflies, that’s fine; but such work must not be confounded with research, which is concerned to discover explanatory principles of some depth and fails if it has not done so. Did the human capacity for language evolve gradually? No, it suddenly appeared around 50,000 years ago after a freak gene mutation: (Language and Mind, third edition, pg, 183-184) An elementary fact about the language faculty is that it is a system of discrete infinity, rare in the organic world. Any such system is based on a primitive operation that takes objects already constructed, and constructs from them a new object: in the simplest case, the set containing them. Call that operation Merge. Either Merge or some equivalent is a minimal requirement. With Merge available, we instantly have an unbounded system of hierarchically structured expressions. The simplest account of the “Great Leap Forward” in the evolution of humans would be that the brain was rewired, perhaps by some slight mutation, to provide the operation Merge … There are speculations about the evolution of language that postulate a far more complex process … A more parsimonious speculation is that they did not, and that the Great Leap was effectively instantaneous, in a single individual, who was instantly endowed with intellectual capacities far superior to those of others, transmitted to offspring and coming to predominate. At best a reasonable guess, as are all speculations about such matters, but about the simplest one imaginable, and not inconsistent with anything known or plausibly surmised. It is hard to see what account of human evolution would not assume at least this much, in one or another form. I think all of these positions are kind of insane for reasons that we will discuss later. (Side note: Chomsky’s proposal is essentially the hard takeoff theory of human intelligence.) Most consequential of all, perhaps, are the ways Chomsky has influenced (i) what linguists mainly study, and (ii) how they go about studying it. Naively, since language involves many different components—including sound production and comprehension, intonation, gestures, and context, among many others—linguists might want to study all of these. While they do study all of these, Chomsky and his followers view grammar as by far the most important component of humans’ ability to understand and produce language, and accordingly make it their central focus. Roughly speaking, grammar refers to the set of language-specific rules that determine whether a sentence is well-formed. It goes beyond specifying word order (or ‘surface structure’, in Chomskyan terminology) since one needs to know more than just where words are placed in order to modify or extend a given sentence. Consider a pair of sentences Chomsky uses to illustrate this point in Aspects of the Theory of Syntax (pg. 22), his most cited work: (1a) I expected John to be examined by a specialist. (2a) I persuaded John to be examined by a specialist. The words “expected” and “persuaded” appear in the same location in each sentence, but imply different ‘latent’ grammatical structures, or ‘deep structures’. One way to show this is to observe that a particular way of rearranging the words produces a sentence with the same meaning in the first case (1a = 1b), and a different meaning in the second (2a != 2b): (1b) I expected a specialist to examine John. (2b) I persuaded a specialist to examine John. In particular, the target of persuasion is “John” in the case of (2a), and “the specialist” in the case of (2b). A full Chomskyan treatment of sentences like this would involve hierarchical tree diagrams, which permit a precise description of deep structure. You may have encountered the famous sentence: “Colorless green ideas sleep furiously.” It first appeared in Chomsky’s 1957 book Syntactic Structures, and the point is that even nonsense sentences can be grammatically well-formed, and that speakers can quickly assess the grammatical correctness of even nonsense sentences that they’ve never seen before. To Chomsky, this is one of the most important facts to be explained about language. A naive response to Chomsky’s preoccupation with grammar is: doesn’t real language involve a lot of non-grammatical stuff, like stuttering and slips of the tongue and midstream changes of mind? Of course it does, and Chomsky acknowledges this. To address this point, Chomsky has to move the goalposts in two important ways. First, he famously distinguishes competence from performance, and identifies the former as the subject of any serious theory of language: (Aspects of the Theory of Syntax, Ch. 1, pg. 4) The problem for the linguist, as well as for the child learning the language, is to determine from the data of performance the underlying system of rules that has been mastered by the speaker-hearer and that he puts to use in actual performance. Hence, in the technical sense, linguistic theory is mentalistic, since it is concerned with discovering a mental reality underlying actual behavior. Observed use of language or hypothesized dispositions to respond, habits, and so on, may provide evidence as to the nature of this mental reality, but surely cannot constitute the actual subject matter of linguistics, if this is to be a serious discipline. Moreover, he claims that grammar captures most of what we should mean when we talk about speakers’ linguistic competence: (Aspects of the Theory of Syntax, Ch. 1, pg. 24) A grammar can be regarded as a theory of a language; it is descriptively adequate to the extent that it correctly describes the intrinsic competence of the idealized native speaker. Another way Chomsky moves the goalposts is by distinguishing E-languages, like English and Spanish and Japanese, from I-languages, which only exist inside human minds. He claims that serious linguistics should be primarily interested in the latter. In a semi-technical book summarizing Chomsky’s theory of language, Cook and Newson write: (Chomsky’s Universal Grammar: An Introduction, pg. 13) E-language linguistics … aims to collect samples of language and then describe their properties. … I-language linguistics, however, is concerned with what a speaker knows about language and where this knowledge comes from; it treats language as an internal property of the human mind rather than something external … Not only should linguistics primarily be interested in studying I-languages, but to try and study E-languages at all may be a fool’s errand: (Chomsky’s Universal Grammar: An Introduction, pg. 13) Chomsky claims that the history of generative linguistics shows a shift from an E-language to an I-language approach; ‘the shift of focus from the dubious concept of E-language to the significant notion of I-language was a crucial step in early generative grammar’ (Chomsky, 1991b, pg. 10). … Indeed Chomsky is extremely dismissive of E-language approaches: ‘E-language, if it exists at all, is derivative, remote from mechanisms and of no particular empirical significance, perhaps none at all’ (Chomsky, 1991b, pg. 10).1 I Am Not A Linguist (IANAL), but this redefinition of the primary concern of linguistics seems crazy to me. Is studying a language like English as it is actually used really of no particular empirical significance? And this doesn’t seem to be a one-time hyperbole, but a representative claim. Cook and Newson continue: (Chomsky’s Universal Grammar: An Introduction, pg. 14) The opposition between these two approaches in linguistics has been long and acrimonious, neither side conceding the other’s reality. … The E-linguist despises the I-linguist for not looking at the ‘real’ facts; the I-linguist derides the E-linguist for looking at trivia. The I-language versus E-language distinction is as much a difference of research methods and of admissible evidence as it is of long-term goals. So much for what linguists ought to study. How should they study it? The previous quote gives us a clue. Especially in the era before Chomsky (BC), linguists were more interested in description. Linguists were, at least in one view, people who could be dropped anywhere in the world, and emerge with a tentative grammar of the local language six months later. (A notion like this is mentioned early in this video.) Linguists catalog the myriad of strange details about human languages, like the fact that some languages don’t appear to have words for relative directions, or “thank you”, or “yes” and “no”. After Chomsky's domination of the field (AD), there were a lot more theorists. While you could study language by going out into the field and collecting data, this was viewed as not the only, and maybe not even the most important, way to work. Diagrams of sentences proliferated. Chomsky, arguably the most influential linguist of the past hundred years, has never done fieldwork. In summary, to Chomsky and many of the linguists working in his tradition, the scientifically interesting component of language is grammar competence, and real linguistic data only indirectly reflects it. All of this matters because the dominance of Chomskyan linguistics has had downstream effects in adjacent fields like artificial intelligence (AI), evolutionary biology, and neuroscience. Chomsky has long been an opponent of the statistical learning tradition of language modeling, essentially claiming that it does not provide insight about what humans know about languages, and that engineering success probably can’t be achieved without explicitly incorporating important mathematical facts about the underlying structure of language. Chomsky’s ideas have motivated researchers to look for a “language gene” and “language areas” of the brain. Arguably, no one has yet found either—but more on that later. How Chomsky attained this stranglehold on linguistics is an interesting sociological question, but not our main concern in the present work2. The intent here is not to pooh-pooh Chomsky, either; brilliant and hard-working people are often wrong on important questions. Consider that his academic career began in the early 1950s—over 70 years ago!—when our understanding of language, anthropology, biology, neuroscience, and artificial intelligence, among many other things, was substantially more rudimentary. Where are we going with this? All of this is context for understanding the ideas of a certain bomb-throwing terrorist blight on the face of linguistics: Daniel Everett. How Language Began is a book he wrote about, well, what language is and how it began. Everett is the anti-Chomsky. II. THE MISSIONARY We all love classic boy-meets-girl stories. Here’s one: boy meets girl at a rock concert, they fall in love, the boy converts to Christianity for the girl, then the boy and girl move to the Amazon jungle to dedicate the rest of their lives to saving the souls of an isolated hunter-gatherer tribe. Daniel Everett is the boy in this story. The woman he married, Keren Graham, is the daughter of Christian missionaries and had formative experiences living in the Amazon jungle among the Sateré-Mawé people. At seventeen, Everett became a born-again Christian; at eighteen, he and Keren married; and over the next few years, they started a family and prepared to become full-fledged missionaries like Keren’s parents. First, Everett studied “Bible and Foreign Missions” at the Moody Bible Institute in Chicago. After finishing his degree in 1975, the natural next step was to train more specifically to follow in the footsteps of Keren’s parents. In 1976, he and his wife enrolled in the Summer Institute of Linguistics (SIL) to learn translation techniques and more viscerally prepare for life in the jungle: They were sent to Chiapas, Mexico, where Keren stayed in a hut in the jungle with the couple’s children—by this time, there were three—while Everett underwent grueling field training. He endured fifty-mile hikes and survived for several days deep in the jungle with only matches, water, a rope, a machete, and a flashlight. Everett apparently had a gift for language-learning. This led SIL to invite Everett and his wife to work with the Pirahã people (pronounced pee-da-HAN), whose unusual language had thwarted all previous attempts to learn it. In 1977, Everett’s family moved to Brazil, and in December they met the Pirahã for the first time. As an SIL-affiliated missionary, Everett’s explicit goals were to (i) translate the Bible into Pirahã, and (ii) convert as many Pirahã as possible to Christianity. But Everett’s first encounter with the Pirahã was cut short for political reasons: (Don’t Sleep There Are Snakes, Ch. 1, pg. 13-14) In December of 1977 the Brazilian government ordered all missionaries to leave Indian reservations. … Leaving the village under these forced circumstances made me wonder whether I’d ever be able to return. The Summer Institute of Linguistics was concerned too and wanted to find a way around the government’s prohibition against missionaries. So SIL asked me to apply to the graduate linguistics program at the State University of Campinas (UNICAMP), in the state of São Paulo, Brazil. It was hoped that UNICAMP would be able to secure government authorization for me to visit the Pirahãs for a prolonged period, in spite of the general ban against missionaries. … My work at UNICAMP paid off as SIL hoped it would. Everett became a linguist proper sort of by accident, mostly as an excuse to continue his missionary work. But he ended up developing a passion for it. In 1980, he completed Aspects of the Phonology of Pirahã, his master’s thesis. He continued on to get a PhD in linguistics, also from UNICAMP, and in 1983 finished The Pirahã Language and Theory of Syntax, his dissertation. He continued studying the Pirahã and working as an academic linguist after that. In all, Everett spent around ten years of his life living with the Pirahã, spread out over some thirty-odd years. As he notes in Don’t Sleep, There Are Snakes: (Prologue, pg. xvii-xviii) I went to the Pirahãs when I was twenty-six years old. Now I am old enough to receive senior discounts. I gave them my youth. I have contracted malaria many times. I remember several occasions on which the Pirahãs or others threatened my life. I have carried more heavy boxes, bags, and barrels on my back through the jungle than I care to remember. But my grandchildren all know the Pirahãs. My children are who they are in part because of the Pirahãs. And I can look at some of those old men (old like me) who once threatened to kill me and recognize some of the dearest friends I have ever had—men who would now risk their lives for me. Everett interviewing some Pirahã people. (source) Everett did eventually learn their language, and it’s worth taking a step back to appreciate just how hard that task was. No Pirahã spoke Portuguese, apart from some isolated phrases they used for bartering. They didn’t speak any other language at all—just Pirahã. How do you learn another group’s language when you have no languages in common? The technical term is monolingual fieldwork. But this is just a fancy label for some combination of pointing at things, listening, crude imitation, and obsessively transcribing whatever you hear. For years. It doesn’t help that the Pirahã language seems genuinely hard to learn in a few different senses. First, it is probably conventionally difficult for Westerners to learn since it is a tonal language (two tones: high and low) with a small number of phonemes (building block sounds) and a few unusual sounds3. Second, there is no written language. Third, the language has a variety of ‘channels of discourse’, or ways of talking specialized for one or another cultural context. One of these is ‘whistle speech’; Pirahãs can communicate purely in whistles. This feature appears to be extremely useful during hunting trips: (Don’t Sleep, There Are Snakes, Ch. 11, pg. 187-188) My first intense contact with whistle speech came one day when the Pirahãs had given me permission to go hunting with them. After we’d been walking for about an hour, they decided that they weren’t seeing any game because I, with my clunking canteens and machete and congenital clumsiness, was making too much noise. “You stay here and we will be back for you later.” Xaikáibaí said gently but firmly. … As I tried to make the best of my solitary confinement, I heard the men whistling to one another. They were saying, “I’ll go over there; you go that way,” and other such hunting talk. But clearly they were communicating. It was fascinating because it sounded so different from anything I had heard before. The whistle carried long and clear in the jungle. I could immediately see the importance and usefulness of this channel, which I guessed would also be much less likely to scare away game than the lower frequencies of the men’s normal voices. Fourth, important aspects of the language reflect core tenets of Pirahã culture in ways that one might not a priori expect. Everett writes extensively about the ‘immediacy of experience principle’ of Pirahã culture, which he summarizes as the idea that: (Don’t Sleep, There Are Snakes, Ch. 7, pg. 132) Declarative Pirahã utterances contain only assertions related directly to the moment of speech, either experienced by the speaker or witnessed by someone alive during the lifetime of the speaker. One way the language reflects this is that the speaker must specify how they know something by affixing an appropriate suffix to verbs: (Don’t Sleep, There Are Snakes, Ch. 12, pg. 196) Perhaps the most interesting suffixes, however (though these are not unique to Pirahã), are what linguists call evidentials, elements that represent the speaker’s evaluation of his or her knowledge of what he or she is saying. There are three of these in Pirahã: hearsay, observation, and deduction. To see what these do, let’s use an English example. If I ask you, “Did Joe go fishing?” you could answer, “Yes, at least I heard that he did,” or “Yes, I know because I saw him leave,” or “Yes, at least I suppose he did because his boat is gone.” The difference between English and Pirahã is that what English does with a sentence, Pirahã does with a verbal suffix. Everett also convincingly links this cultural principle to the lack of Pirahã number words and creation myths. On the latter topic, Everett recalls the following exchange: (Don’t Sleep, There Are Snakes, Ch. 7, pg. 134) I sat with Kóhoi once and he asked me, after hearing about my god, “What else does your god do?” And I answered, “Well, he made the stars, and he made the earth.” Then I asked, “What do the Pirahãs say?” He answered, “Well, the Pirahãs say that these things were not made.” And all of this is to say nothing of the manifold perils of the jungle: malaria, typhoid fever, dysentery, dangerous snakes, insects, morally gray river traders, and periodic downpours. If Indiana Jones braved these conditions for years, we would consider his stories rousing adventures. Everett did this while also learning one of the most unusual languages in the world. People on the bank of the Maici river. (source) By the way, he did eventually sort of achieve his goal of translating the Bible. Armed with a solid knowledge of Pirahã, he was able to translate the New Testament’s Gospel of Mark. Since the Pirahã have no written language, he provided them with a recorded version, but did not get the reaction he expected: (Don’t Sleep, There Are Snakes, Ch. 17, pg. 267-268) When we returned to the village, I recorded Mark’s gospel in my own voice for the Pirahãs to listen to. I then brought in a wind-up tape recorder to play the recording, and I taught the Pirahãs how to use it, which, surprisingly enough, some of the children did. Keren and I left the village and returned a few weeks later. The people were still listening to the gospel, with children cranking the recorder. I was initially quite excited about this, until it became clear that the only part of the book that they paid attention to was the beheading of John the Baptist. “Wow, they cut off his head. Play that again!” One reaction to hearing the gospel caught Everett even more off-guard: (Don’t Sleep, There Are Snakes, Ch. 17, pg. 269) "The women are afraid of Jesus. We do not want him." "Why not?" I asked, wondering what had triggered this declaration. "Because last night he came to our village and tried to have sex with our women. He chased them around the village, trying to stick his large penis into them." Kaaxaóoi proceeded to show me with his two hands held far apart how long Jesus's penis was—a good three feet. But the Pirahã had an even more serious objection to Jesus: (Don’t Sleep, There Are Snakes, Ch. 17, pg. 265-266) Part of the difficulty of my task began to become clear to me. I communicated more or less correctly to the Pirahãs about my Christian beliefs. The men listening to me understood that there was a man named Hisó, Jesus, and that he wanted others to do what he told them. "The Pirahã men then asked, "Hey Dan, what does Jesus look like? Is he dark like us or light like you?" I said, "Well, I have never actually seen him. He lived a long time ago. But I do have his words." "Well, Dan, how do you have his words if you have never heard him or seen him?" They then made it clear that if I had not actually seen this guy (and not in any metaphorical sense, but literally), they weren't interested in any stories I had to tell about him. Period. This is because, as I now knew, the Pirahãs believe only what they see. Sometimes they also believe in things that someone else has told them, so long as that person has personally witnessed what he or she is reporting. In the end, Everett never converted a single Pirahã. But he did even worse than converting zero people—he lost his own faith after coming to believe that the Pirahã had a good point. After keeping this to himself for many years, he revealed his loss of faith to his family, which led to a divorce and his children breaking contact with him for a number of years afterward. But Everett losing his faith in the God of Abraham was only the beginning. Most importantly for us, he also lost his faith in the God of Linguistics—Noam Chomsky. III. THE WAR In 2005, Everett’s paper “Cultural constraints on grammar and cognition in Pirahã: Another look at the design features of human language” was published in the journal Cultural Anthropology. An outsider might expect an article like this, which made a technical observation about the apparent lack of a property called ‘recursion’ in the Pirahã language, to receive an ‘oh, neat’ sort of response. Languages can be pretty different from one another, after all. Mandarin lacks plurals. Spanish sentences can omit an explicit subject. This is one of those kinds of things. But the article ignited a firestorm of controversy that follows Everett to this day. Praise for Everett and his work on recursion in Pirahã: He became a pure charlatan, although he used to be a good descriptive linguist. That is why, as far as I know, all the serious linguists who work on Brazilian languages ignore him. Noam Chomsky, MIT professor and linguist
Inline links: Wikipedia, hard takeoff, grammar, 1, this video, don’t appear to have words for relative directions, “thank you”, “yes” and “no”, long been an opponent, 2, Daniel Everett, Sateré-Mawé people, prepared, Bible and Foreign Missions, 1975, SIL, viscerally prepare, Pirahã people, https://substackcdn.com/image/fetch/$s_!42Ji!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F5c899185-e1a2-4358-ae6a-e9298f6c7cdb_1600x1002.jpeg, source, 3, number words, https://substackcdn.com/image/fetch/$s_!yx-R!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F77975f2c-ef0f-47d7-9ed9-f22bbe04f78b_1024x768.jpeg, source, Cultural constraints on grammar and cognition in Pirahã: Another look at the design features of human language
Everett interviewing some Pirahã people. (source) Everett did eventually learn their language, and it’s worth taking a step back to appreciate just how hard that task was. No Pirahã spoke Portuguese, apart from some isolated phrases they used for bartering. They didn’t speak any other language at all—just Pirahã. How do you learn another group’s language when you have no languages in common? The technical term is monolingual fieldwork. But this is just a fancy label for some combination of pointing at things, listening, crude imitation, and obsessively transcribing whatever you hear. For years. It doesn’t help that the Pirahã language seems genuinely hard to learn in a few different senses. First, it is probably conventionally difficult for Westerners to learn since it is a tonal language (two tones: high and low) with a small number of phonemes (building block sounds) and a few unusual sounds3. Second, there is no written language. Third, the language has a variety of ‘channels of discourse’, or ways of talking specialized for one or another cultural context. One of these is ‘whistle speech’; Pirahãs can communicate purely in whistles. This feature appears to be extremely useful during hunting trips: (Don’t Sleep, There Are Snakes, Ch. 11, pg. 187-188) My first intense contact with whistle speech came one day when the Pirahãs had given me permission to go hunting with them. After we’d been walking for about an hour, they decided that they weren’t seeing any game because I, with my clunking canteens and machete and congenital clumsiness, was making too much noise. “You stay here and we will be back for you later.” Xaikáibaí said gently but firmly. … As I tried to make the best of my solitary confinement, I heard the men whistling to one another. They were saying, “I’ll go over there; you go that way,” and other such hunting talk. But clearly they were communicating. It was fascinating because it sounded so different from anything I had heard before. The whistle carried long and clear in the jungle. I could immediately see the importance and usefulness of this channel, which I guessed would also be much less likely to scare away game than the lower frequencies of the men’s normal voices. Fourth, important aspects of the language reflect core tenets of Pirahã culture in ways that one might not a priori expect. Everett writes extensively about the ‘immediacy of experience principle’ of Pirahã culture, which he summarizes as the idea that: (Don’t Sleep, There Are Snakes, Ch. 7, pg. 132) Declarative Pirahã utterances contain only assertions related directly to the moment of speech, either experienced by the speaker or witnessed by someone alive during the lifetime of the speaker. One way the language reflects this is that the speaker must specify how they know something by affixing an appropriate suffix to verbs: (Don’t Sleep, There Are Snakes, Ch. 12, pg. 196) Perhaps the most interesting suffixes, however (though these are not unique to Pirahã), are what linguists call evidentials, elements that represent the speaker’s evaluation of his or her knowledge of what he or she is saying. There are three of these in Pirahã: hearsay, observation, and deduction. To see what these do, let’s use an English example. If I ask you, “Did Joe go fishing?” you could answer, “Yes, at least I heard that he did,” or “Yes, I know because I saw him leave,” or “Yes, at least I suppose he did because his boat is gone.” The difference between English and Pirahã is that what English does with a sentence, Pirahã does with a verbal suffix. Everett also convincingly links this cultural principle to the lack of Pirahã number words and creation myths. On the latter topic, Everett recalls the following exchange: (Don’t Sleep, There Are Snakes, Ch. 7, pg. 134) I sat with Kóhoi once and he asked me, after hearing about my god, “What else does your god do?” And I answered, “Well, he made the stars, and he made the earth.” Then I asked, “What do the Pirahãs say?” He answered, “Well, the Pirahãs say that these things were not made.” And all of this is to say nothing of the manifold perils of the jungle: malaria, typhoid fever, dysentery, dangerous snakes, insects, morally gray river traders, and periodic downpours. If Indiana Jones braved these conditions for years, we would consider his stories rousing adventures. Everett did this while also learning one of the most unusual languages in the world. People on the bank of the Maici river. (source) By the way, he did eventually sort of achieve his goal of translating the Bible. Armed with a solid knowledge of Pirahã, he was able to translate the New Testament’s Gospel of Mark. Since the Pirahã have no written language, he provided them with a recorded version, but did not get the reaction he expected: (Don’t Sleep, There Are Snakes, Ch. 17, pg. 267-268) When we returned to the village, I recorded Mark’s gospel in my own voice for the Pirahãs to listen to. I then brought in a wind-up tape recorder to play the recording, and I taught the Pirahãs how to use it, which, surprisingly enough, some of the children did. Keren and I left the village and returned a few weeks later. The people were still listening to the gospel, with children cranking the recorder. I was initially quite excited about this, until it became clear that the only part of the book that they paid attention to was the beheading of John the Baptist. “Wow, they cut off his head. Play that again!” One reaction to hearing the gospel caught Everett even more off-guard: (Don’t Sleep, There Are Snakes, Ch. 17, pg. 269) "The women are afraid of Jesus. We do not want him." "Why not?" I asked, wondering what had triggered this declaration. "Because last night he came to our village and tried to have sex with our women. He chased them around the village, trying to stick his large penis into them." Kaaxaóoi proceeded to show me with his two hands held far apart how long Jesus's penis was—a good three feet. But the Pirahã had an even more serious objection to Jesus: (Don’t Sleep, There Are Snakes, Ch. 17, pg. 265-266) Part of the difficulty of my task began to become clear to me. I communicated more or less correctly to the Pirahãs about my Christian beliefs. The men listening to me understood that there was a man named Hisó, Jesus, and that he wanted others to do what he told them. "The Pirahã men then asked, "Hey Dan, what does Jesus look like? Is he dark like us or light like you?" I said, "Well, I have never actually seen him. He lived a long time ago. But I do have his words." "Well, Dan, how do you have his words if you have never heard him or seen him?" They then made it clear that if I had not actually seen this guy (and not in any metaphorical sense, but literally), they weren't interested in any stories I had to tell about him. Period. This is because, as I now knew, the Pirahãs believe only what they see. Sometimes they also believe in things that someone else has told them, so long as that person has personally witnessed what he or she is reporting. In the end, Everett never converted a single Pirahã. But he did even worse than converting zero people—he lost his own faith after coming to believe that the Pirahã had a good point. After keeping this to himself for many years, he revealed his loss of faith to his family, which led to a divorce and his children breaking contact with him for a number of years afterward. But Everett losing his faith in the God of Abraham was only the beginning. Most importantly for us, he also lost his faith in the God of Linguistics—Noam Chomsky. III. THE WAR In 2005, Everett’s paper “Cultural constraints on grammar and cognition in Pirahã: Another look at the design features of human language” was published in the journal Cultural Anthropology. An outsider might expect an article like this, which made a technical observation about the apparent lack of a property called ‘recursion’ in the Pirahã language, to receive an ‘oh, neat’ sort of response. Languages can be pretty different from one another, after all. Mandarin lacks plurals. Spanish sentences can omit an explicit subject. This is one of those kinds of things. But the article ignited a firestorm of controversy that follows Everett to this day. Praise for Everett and his work on recursion in Pirahã: He became a pure charlatan, although he used to be a good descriptive linguist. That is why, as far as I know, all the serious linguists who work on Brazilian languages ignore him. Noam Chomsky, MIT professor and linguist
Inline links: source, monolingual fieldwork, 3, number words, https://substackcdn.com/image/fetch/$s_!yx-R!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F77975f2c-ef0f-47d7-9ed9-f22bbe04f78b_1024x768.jpeg, source, Cultural constraints on grammar and cognition in Pirahã: Another look at the design features of human language
Pirahãs1 mentions across 1 issues

Pirahãs is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between July 19, 2024 and July 19, 2024. The archive places it in contexts such as "What do the Pirahãs say?". It most often appears alongside Alan Turing, Amazon, Amazon jungle.

Reference entry
Pirahãs
Mention count
1
Issue count
1
First seen
July 19, 2024
Last seen
July 19, 2024
Outbound links
Issue trail
Related pages
Source context
Your Book Review: How Language Began
July 19, 2024 · Original source
This is what he looks like. According to Wikipedia, the context for this picture is: “Noam Chomsky speaks about humanity's prospects for survival” Since around 1957, Chomsky has dominated linguistics. And this matters because he is kind of a contrarian with weird ideas. Is language for communicating? No, it’s mainly for thinking: (What Kind of Creatures Are We? Ch. 1, pg. 15-16) It is, indeed, virtual dogma that the function of language is communication. ... there is by now quite significant evidence that it is simply false. Doubtless language is sometimes used for communication, as is style of dress, facial expression and stance, and much else. But fundamental properties of language design indicate that a rich tradition is correct in regarding language as essentially an instrument of thought, even if we do not go as far as Humboldt in identifying the two. Should linguists care about the interaction between culture and language? No, that’s essentially stamp-collecting: (Language and Responsibility, Ch. 2, pg. 56-57) Again, a discipline is defined in terms of its object and its results. Sociology is the study of society. As to its results, it seems that there are few things one can say about that, at least at a fairly general level. One finds observations, intuitions, impressions, some valid generalizations perhaps. All very valuable, no doubt, but not at the level of explanatory principles. … Sociolinguistics is, I suppose, a discipline that seeks to apply principles of sociology to the study of language; but I suspect that it can draw little from sociology, and I wonder whether it is likely to contribute much to it. … You can also collect butterflies and make many observations. If you like butterflies, that’s fine; but such work must not be confounded with research, which is concerned to discover explanatory principles of some depth and fails if it has not done so. Did the human capacity for language evolve gradually? No, it suddenly appeared around 50,000 years ago after a freak gene mutation: (Language and Mind, third edition, pg, 183-184) An elementary fact about the language faculty is that it is a system of discrete infinity, rare in the organic world. Any such system is based on a primitive operation that takes objects already constructed, and constructs from them a new object: in the simplest case, the set containing them. Call that operation Merge. Either Merge or some equivalent is a minimal requirement. With Merge available, we instantly have an unbounded system of hierarchically structured expressions. The simplest account of the “Great Leap Forward” in the evolution of humans would be that the brain was rewired, perhaps by some slight mutation, to provide the operation Merge … There are speculations about the evolution of language that postulate a far more complex process … A more parsimonious speculation is that they did not, and that the Great Leap was effectively instantaneous, in a single individual, who was instantly endowed with intellectual capacities far superior to those of others, transmitted to offspring and coming to predominate. At best a reasonable guess, as are all speculations about such matters, but about the simplest one imaginable, and not inconsistent with anything known or plausibly surmised. It is hard to see what account of human evolution would not assume at least this much, in one or another form. I think all of these positions are kind of insane for reasons that we will discuss later. (Side note: Chomsky’s proposal is essentially the hard takeoff theory of human intelligence.) Most consequential of all, perhaps, are the ways Chomsky has influenced (i) what linguists mainly study, and (ii) how they go about studying it. Naively, since language involves many different components—including sound production and comprehension, intonation, gestures, and context, among many others—linguists might want to study all of these. While they do study all of these, Chomsky and his followers view grammar as by far the most important component of humans’ ability to understand and produce language, and accordingly make it their central focus. Roughly speaking, grammar refers to the set of language-specific rules that determine whether a sentence is well-formed. It goes beyond specifying word order (or ‘surface structure’, in Chomskyan terminology) since one needs to know more than just where words are placed in order to modify or extend a given sentence. Consider a pair of sentences Chomsky uses to illustrate this point in Aspects of the Theory of Syntax (pg. 22), his most cited work: (1a) I expected John to be examined by a specialist. (2a) I persuaded John to be examined by a specialist. The words “expected” and “persuaded” appear in the same location in each sentence, but imply different ‘latent’ grammatical structures, or ‘deep structures’. One way to show this is to observe that a particular way of rearranging the words produces a sentence with the same meaning in the first case (1a = 1b), and a different meaning in the second (2a != 2b): (1b) I expected a specialist to examine John. (2b) I persuaded a specialist to examine John. In particular, the target of persuasion is “John” in the case of (2a), and “the specialist” in the case of (2b). A full Chomskyan treatment of sentences like this would involve hierarchical tree diagrams, which permit a precise description of deep structure. You may have encountered the famous sentence: “Colorless green ideas sleep furiously.” It first appeared in Chomsky’s 1957 book Syntactic Structures, and the point is that even nonsense sentences can be grammatically well-formed, and that speakers can quickly assess the grammatical correctness of even nonsense sentences that they’ve never seen before. To Chomsky, this is one of the most important facts to be explained about language. A naive response to Chomsky’s preoccupation with grammar is: doesn’t real language involve a lot of non-grammatical stuff, like stuttering and slips of the tongue and midstream changes of mind? Of course it does, and Chomsky acknowledges this. To address this point, Chomsky has to move the goalposts in two important ways. First, he famously distinguishes competence from performance, and identifies the former as the subject of any serious theory of language: (Aspects of the Theory of Syntax, Ch. 1, pg. 4) The problem for the linguist, as well as for the child learning the language, is to determine from the data of performance the underlying system of rules that has been mastered by the speaker-hearer and that he puts to use in actual performance. Hence, in the technical sense, linguistic theory is mentalistic, since it is concerned with discovering a mental reality underlying actual behavior. Observed use of language or hypothesized dispositions to respond, habits, and so on, may provide evidence as to the nature of this mental reality, but surely cannot constitute the actual subject matter of linguistics, if this is to be a serious discipline. Moreover, he claims that grammar captures most of what we should mean when we talk about speakers’ linguistic competence: (Aspects of the Theory of Syntax, Ch. 1, pg. 24) A grammar can be regarded as a theory of a language; it is descriptively adequate to the extent that it correctly describes the intrinsic competence of the idealized native speaker. Another way Chomsky moves the goalposts is by distinguishing E-languages, like English and Spanish and Japanese, from I-languages, which only exist inside human minds. He claims that serious linguistics should be primarily interested in the latter. In a semi-technical book summarizing Chomsky’s theory of language, Cook and Newson write: (Chomsky’s Universal Grammar: An Introduction, pg. 13) E-language linguistics … aims to collect samples of language and then describe their properties. … I-language linguistics, however, is concerned with what a speaker knows about language and where this knowledge comes from; it treats language as an internal property of the human mind rather than something external … Not only should linguistics primarily be interested in studying I-languages, but to try and study E-languages at all may be a fool’s errand: (Chomsky’s Universal Grammar: An Introduction, pg. 13) Chomsky claims that the history of generative linguistics shows a shift from an E-language to an I-language approach; ‘the shift of focus from the dubious concept of E-language to the significant notion of I-language was a crucial step in early generative grammar’ (Chomsky, 1991b, pg. 10). … Indeed Chomsky is extremely dismissive of E-language approaches: ‘E-language, if it exists at all, is derivative, remote from mechanisms and of no particular empirical significance, perhaps none at all’ (Chomsky, 1991b, pg. 10).1 I Am Not A Linguist (IANAL), but this redefinition of the primary concern of linguistics seems crazy to me. Is studying a language like English as it is actually used really of no particular empirical significance? And this doesn’t seem to be a one-time hyperbole, but a representative claim. Cook and Newson continue: (Chomsky’s Universal Grammar: An Introduction, pg. 14) The opposition between these two approaches in linguistics has been long and acrimonious, neither side conceding the other’s reality. … The E-linguist despises the I-linguist for not looking at the ‘real’ facts; the I-linguist derides the E-linguist for looking at trivia. The I-language versus E-language distinction is as much a difference of research methods and of admissible evidence as it is of long-term goals. So much for what linguists ought to study. How should they study it? The previous quote gives us a clue. Especially in the era before Chomsky (BC), linguists were more interested in description. Linguists were, at least in one view, people who could be dropped anywhere in the world, and emerge with a tentative grammar of the local language six months later. (A notion like this is mentioned early in this video.) Linguists catalog the myriad of strange details about human languages, like the fact that some languages don’t appear to have words for relative directions, or “thank you”, or “yes” and “no”. After Chomsky's domination of the field (AD), there were a lot more theorists. While you could study language by going out into the field and collecting data, this was viewed as not the only, and maybe not even the most important, way to work. Diagrams of sentences proliferated. Chomsky, arguably the most influential linguist of the past hundred years, has never done fieldwork. In summary, to Chomsky and many of the linguists working in his tradition, the scientifically interesting component of language is grammar competence, and real linguistic data only indirectly reflects it. All of this matters because the dominance of Chomskyan linguistics has had downstream effects in adjacent fields like artificial intelligence (AI), evolutionary biology, and neuroscience. Chomsky has long been an opponent of the statistical learning tradition of language modeling, essentially claiming that it does not provide insight about what humans know about languages, and that engineering success probably can’t be achieved without explicitly incorporating important mathematical facts about the underlying structure of language. Chomsky’s ideas have motivated researchers to look for a “language gene” and “language areas” of the brain. Arguably, no one has yet found either—but more on that later. How Chomsky attained this stranglehold on linguistics is an interesting sociological question, but not our main concern in the present work2. The intent here is not to pooh-pooh Chomsky, either; brilliant and hard-working people are often wrong on important questions. Consider that his academic career began in the early 1950s—over 70 years ago!—when our understanding of language, anthropology, biology, neuroscience, and artificial intelligence, among many other things, was substantially more rudimentary. Where are we going with this? All of this is context for understanding the ideas of a certain bomb-throwing terrorist blight on the face of linguistics: Daniel Everett. How Language Began is a book he wrote about, well, what language is and how it began. Everett is the anti-Chomsky. II. THE MISSIONARY We all love classic boy-meets-girl stories. Here’s one: boy meets girl at a rock concert, they fall in love, the boy converts to Christianity for the girl, then the boy and girl move to the Amazon jungle to dedicate the rest of their lives to saving the souls of an isolated hunter-gatherer tribe. Daniel Everett is the boy in this story. The woman he married, Keren Graham, is the daughter of Christian missionaries and had formative experiences living in the Amazon jungle among the Sateré-Mawé people. At seventeen, Everett became a born-again Christian; at eighteen, he and Keren married; and over the next few years, they started a family and prepared to become full-fledged missionaries like Keren’s parents. First, Everett studied “Bible and Foreign Missions” at the Moody Bible Institute in Chicago. After finishing his degree in 1975, the natural next step was to train more specifically to follow in the footsteps of Keren’s parents. In 1976, he and his wife enrolled in the Summer Institute of Linguistics (SIL) to learn translation techniques and more viscerally prepare for life in the jungle: They were sent to Chiapas, Mexico, where Keren stayed in a hut in the jungle with the couple’s children—by this time, there were three—while Everett underwent grueling field training. He endured fifty-mile hikes and survived for several days deep in the jungle with only matches, water, a rope, a machete, and a flashlight. Everett apparently had a gift for language-learning. This led SIL to invite Everett and his wife to work with the Pirahã people (pronounced pee-da-HAN), whose unusual language had thwarted all previous attempts to learn it. In 1977, Everett’s family moved to Brazil, and in December they met the Pirahã for the first time. As an SIL-affiliated missionary, Everett’s explicit goals were to (i) translate the Bible into Pirahã, and (ii) convert as many Pirahã as possible to Christianity. But Everett’s first encounter with the Pirahã was cut short for political reasons: (Don’t Sleep There Are Snakes, Ch. 1, pg. 13-14) In December of 1977 the Brazilian government ordered all missionaries to leave Indian reservations. … Leaving the village under these forced circumstances made me wonder whether I’d ever be able to return. The Summer Institute of Linguistics was concerned too and wanted to find a way around the government’s prohibition against missionaries. So SIL asked me to apply to the graduate linguistics program at the State University of Campinas (UNICAMP), in the state of São Paulo, Brazil. It was hoped that UNICAMP would be able to secure government authorization for me to visit the Pirahãs for a prolonged period, in spite of the general ban against missionaries. … My work at UNICAMP paid off as SIL hoped it would. Everett became a linguist proper sort of by accident, mostly as an excuse to continue his missionary work. But he ended up developing a passion for it. In 1980, he completed Aspects of the Phonology of Pirahã, his master’s thesis. He continued on to get a PhD in linguistics, also from UNICAMP, and in 1983 finished The Pirahã Language and Theory of Syntax, his dissertation. He continued studying the Pirahã and working as an academic linguist after that. In all, Everett spent around ten years of his life living with the Pirahã, spread out over some thirty-odd years. As he notes in Don’t Sleep, There Are Snakes: (Prologue, pg. xvii-xviii) I went to the Pirahãs when I was twenty-six years old. Now I am old enough to receive senior discounts. I gave them my youth. I have contracted malaria many times. I remember several occasions on which the Pirahãs or others threatened my life. I have carried more heavy boxes, bags, and barrels on my back through the jungle than I care to remember. But my grandchildren all know the Pirahãs. My children are who they are in part because of the Pirahãs. And I can look at some of those old men (old like me) who once threatened to kill me and recognize some of the dearest friends I have ever had—men who would now risk their lives for me. Everett interviewing some Pirahã people. (source) Everett did eventually learn their language, and it’s worth taking a step back to appreciate just how hard that task was. No Pirahã spoke Portuguese, apart from some isolated phrases they used for bartering. They didn’t speak any other language at all—just Pirahã. How do you learn another group’s language when you have no languages in common? The technical term is monolingual fieldwork. But this is just a fancy label for some combination of pointing at things, listening, crude imitation, and obsessively transcribing whatever you hear. For years. It doesn’t help that the Pirahã language seems genuinely hard to learn in a few different senses. First, it is probably conventionally difficult for Westerners to learn since it is a tonal language (two tones: high and low) with a small number of phonemes (building block sounds) and a few unusual sounds3. Second, there is no written language. Third, the language has a variety of ‘channels of discourse’, or ways of talking specialized for one or another cultural context. One of these is ‘whistle speech’; Pirahãs can communicate purely in whistles. This feature appears to be extremely useful during hunting trips: (Don’t Sleep, There Are Snakes, Ch. 11, pg. 187-188) My first intense contact with whistle speech came one day when the Pirahãs had given me permission to go hunting with them. After we’d been walking for about an hour, they decided that they weren’t seeing any game because I, with my clunking canteens and machete and congenital clumsiness, was making too much noise. “You stay here and we will be back for you later.” Xaikáibaí said gently but firmly. … As I tried to make the best of my solitary confinement, I heard the men whistling to one another. They were saying, “I’ll go over there; you go that way,” and other such hunting talk. But clearly they were communicating. It was fascinating because it sounded so different from anything I had heard before. The whistle carried long and clear in the jungle. I could immediately see the importance and usefulness of this channel, which I guessed would also be much less likely to scare away game than the lower frequencies of the men’s normal voices. Fourth, important aspects of the language reflect core tenets of Pirahã culture in ways that one might not a priori expect. Everett writes extensively about the ‘immediacy of experience principle’ of Pirahã culture, which he summarizes as the idea that: (Don’t Sleep, There Are Snakes, Ch. 7, pg. 132) Declarative Pirahã utterances contain only assertions related directly to the moment of speech, either experienced by the speaker or witnessed by someone alive during the lifetime of the speaker. One way the language reflects this is that the speaker must specify how they know something by affixing an appropriate suffix to verbs: (Don’t Sleep, There Are Snakes, Ch. 12, pg. 196) Perhaps the most interesting suffixes, however (though these are not unique to Pirahã), are what linguists call evidentials, elements that represent the speaker’s evaluation of his or her knowledge of what he or she is saying. There are three of these in Pirahã: hearsay, observation, and deduction. To see what these do, let’s use an English example. If I ask you, “Did Joe go fishing?” you could answer, “Yes, at least I heard that he did,” or “Yes, I know because I saw him leave,” or “Yes, at least I suppose he did because his boat is gone.” The difference between English and Pirahã is that what English does with a sentence, Pirahã does with a verbal suffix. Everett also convincingly links this cultural principle to the lack of Pirahã number words and creation myths. On the latter topic, Everett recalls the following exchange: (Don’t Sleep, There Are Snakes, Ch. 7, pg. 134) I sat with Kóhoi once and he asked me, after hearing about my god, “What else does your god do?” And I answered, “Well, he made the stars, and he made the earth.” Then I asked, “What do the Pirahãs say?” He answered, “Well, the Pirahãs say that these things were not made.” And all of this is to say nothing of the manifold perils of the jungle: malaria, typhoid fever, dysentery, dangerous snakes, insects, morally gray river traders, and periodic downpours. If Indiana Jones braved these conditions for years, we would consider his stories rousing adventures. Everett did this while also learning one of the most unusual languages in the world. People on the bank of the Maici river. (source) By the way, he did eventually sort of achieve his goal of translating the Bible. Armed with a solid knowledge of Pirahã, he was able to translate the New Testament’s Gospel of Mark. Since the Pirahã have no written language, he provided them with a recorded version, but did not get the reaction he expected: (Don’t Sleep, There Are Snakes, Ch. 17, pg. 267-268) When we returned to the village, I recorded Mark’s gospel in my own voice for the Pirahãs to listen to. I then brought in a wind-up tape recorder to play the recording, and I taught the Pirahãs how to use it, which, surprisingly enough, some of the children did. Keren and I left the village and returned a few weeks later. The people were still listening to the gospel, with children cranking the recorder. I was initially quite excited about this, until it became clear that the only part of the book that they paid attention to was the beheading of John the Baptist. “Wow, they cut off his head. Play that again!” One reaction to hearing the gospel caught Everett even more off-guard: (Don’t Sleep, There Are Snakes, Ch. 17, pg. 269) "The women are afraid of Jesus. We do not want him." "Why not?" I asked, wondering what had triggered this declaration. "Because last night he came to our village and tried to have sex with our women. He chased them around the village, trying to stick his large penis into them." Kaaxaóoi proceeded to show me with his two hands held far apart how long Jesus's penis was—a good three feet. But the Pirahã had an even more serious objection to Jesus: (Don’t Sleep, There Are Snakes, Ch. 17, pg. 265-266) Part of the difficulty of my task began to become clear to me. I communicated more or less correctly to the Pirahãs about my Christian beliefs. The men listening to me understood that there was a man named Hisó, Jesus, and that he wanted others to do what he told them. "The Pirahã men then asked, "Hey Dan, what does Jesus look like? Is he dark like us or light like you?" I said, "Well, I have never actually seen him. He lived a long time ago. But I do have his words." "Well, Dan, how do you have his words if you have never heard him or seen him?" They then made it clear that if I had not actually seen this guy (and not in any metaphorical sense, but literally), they weren't interested in any stories I had to tell about him. Period. This is because, as I now knew, the Pirahãs believe only what they see. Sometimes they also believe in things that someone else has told them, so long as that person has personally witnessed what he or she is reporting. In the end, Everett never converted a single Pirahã. But he did even worse than converting zero people—he lost his own faith after coming to believe that the Pirahã had a good point. After keeping this to himself for many years, he revealed his loss of faith to his family, which led to a divorce and his children breaking contact with him for a number of years afterward. But Everett losing his faith in the God of Abraham was only the beginning. Most importantly for us, he also lost his faith in the God of Linguistics—Noam Chomsky. III. THE WAR In 2005, Everett’s paper “Cultural constraints on grammar and cognition in Pirahã: Another look at the design features of human language” was published in the journal Cultural Anthropology. An outsider might expect an article like this, which made a technical observation about the apparent lack of a property called ‘recursion’ in the Pirahã language, to receive an ‘oh, neat’ sort of response. Languages can be pretty different from one another, after all. Mandarin lacks plurals. Spanish sentences can omit an explicit subject. This is one of those kinds of things. But the article ignited a firestorm of controversy that follows Everett to this day. Praise for Everett and his work on recursion in Pirahã: He became a pure charlatan, although he used to be a good descriptive linguist. That is why, as far as I know, all the serious linguists who work on Brazilian languages ignore him. Noam Chomsky, MIT professor and linguist
Inline links: Wikipedia, hard takeoff, grammar, 1, this video, don’t appear to have words for relative directions, “thank you”, “yes” and “no”, long been an opponent, 2, Daniel Everett, Sateré-Mawé people, prepared, Bible and Foreign Missions, 1975, SIL, viscerally prepare, Pirahã people, https://substackcdn.com/image/fetch/$s_!42Ji!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F5c899185-e1a2-4358-ae6a-e9298f6c7cdb_1600x1002.jpeg, source, 3, number words, https://substackcdn.com/image/fetch/$s_!yx-R!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F77975f2c-ef0f-47d7-9ed9-f22bbe04f78b_1024x768.jpeg, source, Cultural constraints on grammar and cognition in Pirahã: Another look at the design features of human language
Everett interviewing some Pirahã people. (source) Everett did eventually learn their language, and it’s worth taking a step back to appreciate just how hard that task was. No Pirahã spoke Portuguese, apart from some isolated phrases they used for bartering. They didn’t speak any other language at all—just Pirahã. How do you learn another group’s language when you have no languages in common? The technical term is monolingual fieldwork. But this is just a fancy label for some combination of pointing at things, listening, crude imitation, and obsessively transcribing whatever you hear. For years. It doesn’t help that the Pirahã language seems genuinely hard to learn in a few different senses. First, it is probably conventionally difficult for Westerners to learn since it is a tonal language (two tones: high and low) with a small number of phonemes (building block sounds) and a few unusual sounds3. Second, there is no written language. Third, the language has a variety of ‘channels of discourse’, or ways of talking specialized for one or another cultural context. One of these is ‘whistle speech’; Pirahãs can communicate purely in whistles. This feature appears to be extremely useful during hunting trips: (Don’t Sleep, There Are Snakes, Ch. 11, pg. 187-188) My first intense contact with whistle speech came one day when the Pirahãs had given me permission to go hunting with them. After we’d been walking for about an hour, they decided that they weren’t seeing any game because I, with my clunking canteens and machete and congenital clumsiness, was making too much noise. “You stay here and we will be back for you later.” Xaikáibaí said gently but firmly. … As I tried to make the best of my solitary confinement, I heard the men whistling to one another. They were saying, “I’ll go over there; you go that way,” and other such hunting talk. But clearly they were communicating. It was fascinating because it sounded so different from anything I had heard before. The whistle carried long and clear in the jungle. I could immediately see the importance and usefulness of this channel, which I guessed would also be much less likely to scare away game than the lower frequencies of the men’s normal voices. Fourth, important aspects of the language reflect core tenets of Pirahã culture in ways that one might not a priori expect. Everett writes extensively about the ‘immediacy of experience principle’ of Pirahã culture, which he summarizes as the idea that: (Don’t Sleep, There Are Snakes, Ch. 7, pg. 132) Declarative Pirahã utterances contain only assertions related directly to the moment of speech, either experienced by the speaker or witnessed by someone alive during the lifetime of the speaker. One way the language reflects this is that the speaker must specify how they know something by affixing an appropriate suffix to verbs: (Don’t Sleep, There Are Snakes, Ch. 12, pg. 196) Perhaps the most interesting suffixes, however (though these are not unique to Pirahã), are what linguists call evidentials, elements that represent the speaker’s evaluation of his or her knowledge of what he or she is saying. There are three of these in Pirahã: hearsay, observation, and deduction. To see what these do, let’s use an English example. If I ask you, “Did Joe go fishing?” you could answer, “Yes, at least I heard that he did,” or “Yes, I know because I saw him leave,” or “Yes, at least I suppose he did because his boat is gone.” The difference between English and Pirahã is that what English does with a sentence, Pirahã does with a verbal suffix. Everett also convincingly links this cultural principle to the lack of Pirahã number words and creation myths. On the latter topic, Everett recalls the following exchange: (Don’t Sleep, There Are Snakes, Ch. 7, pg. 134) I sat with Kóhoi once and he asked me, after hearing about my god, “What else does your god do?” And I answered, “Well, he made the stars, and he made the earth.” Then I asked, “What do the Pirahãs say?” He answered, “Well, the Pirahãs say that these things were not made.” And all of this is to say nothing of the manifold perils of the jungle: malaria, typhoid fever, dysentery, dangerous snakes, insects, morally gray river traders, and periodic downpours. If Indiana Jones braved these conditions for years, we would consider his stories rousing adventures. Everett did this while also learning one of the most unusual languages in the world. People on the bank of the Maici river. (source) By the way, he did eventually sort of achieve his goal of translating the Bible. Armed with a solid knowledge of Pirahã, he was able to translate the New Testament’s Gospel of Mark. Since the Pirahã have no written language, he provided them with a recorded version, but did not get the reaction he expected: (Don’t Sleep, There Are Snakes, Ch. 17, pg. 267-268) When we returned to the village, I recorded Mark’s gospel in my own voice for the Pirahãs to listen to. I then brought in a wind-up tape recorder to play the recording, and I taught the Pirahãs how to use it, which, surprisingly enough, some of the children did. Keren and I left the village and returned a few weeks later. The people were still listening to the gospel, with children cranking the recorder. I was initially quite excited about this, until it became clear that the only part of the book that they paid attention to was the beheading of John the Baptist. “Wow, they cut off his head. Play that again!” One reaction to hearing the gospel caught Everett even more off-guard: (Don’t Sleep, There Are Snakes, Ch. 17, pg. 269) "The women are afraid of Jesus. We do not want him." "Why not?" I asked, wondering what had triggered this declaration. "Because last night he came to our village and tried to have sex with our women. He chased them around the village, trying to stick his large penis into them." Kaaxaóoi proceeded to show me with his two hands held far apart how long Jesus's penis was—a good three feet. But the Pirahã had an even more serious objection to Jesus: (Don’t Sleep, There Are Snakes, Ch. 17, pg. 265-266) Part of the difficulty of my task began to become clear to me. I communicated more or less correctly to the Pirahãs about my Christian beliefs. The men listening to me understood that there was a man named Hisó, Jesus, and that he wanted others to do what he told them. "The Pirahã men then asked, "Hey Dan, what does Jesus look like? Is he dark like us or light like you?" I said, "Well, I have never actually seen him. He lived a long time ago. But I do have his words." "Well, Dan, how do you have his words if you have never heard him or seen him?" They then made it clear that if I had not actually seen this guy (and not in any metaphorical sense, but literally), they weren't interested in any stories I had to tell about him. Period. This is because, as I now knew, the Pirahãs believe only what they see. Sometimes they also believe in things that someone else has told them, so long as that person has personally witnessed what he or she is reporting. In the end, Everett never converted a single Pirahã. But he did even worse than converting zero people—he lost his own faith after coming to believe that the Pirahã had a good point. After keeping this to himself for many years, he revealed his loss of faith to his family, which led to a divorce and his children breaking contact with him for a number of years afterward. But Everett losing his faith in the God of Abraham was only the beginning. Most importantly for us, he also lost his faith in the God of Linguistics—Noam Chomsky. III. THE WAR In 2005, Everett’s paper “Cultural constraints on grammar and cognition in Pirahã: Another look at the design features of human language” was published in the journal Cultural Anthropology. An outsider might expect an article like this, which made a technical observation about the apparent lack of a property called ‘recursion’ in the Pirahã language, to receive an ‘oh, neat’ sort of response. Languages can be pretty different from one another, after all. Mandarin lacks plurals. Spanish sentences can omit an explicit subject. This is one of those kinds of things. But the article ignited a firestorm of controversy that follows Everett to this day. Praise for Everett and his work on recursion in Pirahã: He became a pure charlatan, although he used to be a good descriptive linguist. That is why, as far as I know, all the serious linguists who work on Brazilian languages ignore him. Noam Chomsky, MIT professor and linguist
Inline links: source, monolingual fieldwork, 3, number words, https://substackcdn.com/image/fetch/$s_!yx-R!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F77975f2c-ef0f-47d7-9ed9-f22bbe04f78b_1024x768.jpeg, source, Cultural constraints on grammar and cognition in Pirahã: Another look at the design features of human language
People on the bank of the Maici river. (source) By the way, he did eventually sort of achieve his goal of translating the Bible. Armed with a solid knowledge of Pirahã, he was able to translate the New Testament’s Gospel of Mark. Since the Pirahã have no written language, he provided them with a recorded version, but did not get the reaction he expected: (Don’t Sleep, There Are Snakes, Ch. 17, pg. 267-268) When we returned to the village, I recorded Mark’s gospel in my own voice for the Pirahãs to listen to. I then brought in a wind-up tape recorder to play the recording, and I taught the Pirahãs how to use it, which, surprisingly enough, some of the children did. Keren and I left the village and returned a few weeks later. The people were still listening to the gospel, with children cranking the recorder. I was initially quite excited about this, until it became clear that the only part of the book that they paid attention to was the beheading of John the Baptist. “Wow, they cut off his head. Play that again!” One reaction to hearing the gospel caught Everett even more off-guard: (Don’t Sleep, There Are Snakes, Ch. 17, pg. 269) "The women are afraid of Jesus. We do not want him." "Why not?" I asked, wondering what had triggered this declaration. "Because last night he came to our village and tried to have sex with our women. He chased them around the village, trying to stick his large penis into them." Kaaxaóoi proceeded to show me with his two hands held far apart how long Jesus's penis was—a good three feet. But the Pirahã had an even more serious objection to Jesus: (Don’t Sleep, There Are Snakes, Ch. 17, pg. 265-266) Part of the difficulty of my task began to become clear to me. I communicated more or less correctly to the Pirahãs about my Christian beliefs. The men listening to me understood that there was a man named Hisó, Jesus, and that he wanted others to do what he told them. "The Pirahã men then asked, "Hey Dan, what does Jesus look like? Is he dark like us or light like you?" I said, "Well, I have never actually seen him. He lived a long time ago. But I do have his words." "Well, Dan, how do you have his words if you have never heard him or seen him?" They then made it clear that if I had not actually seen this guy (and not in any metaphorical sense, but literally), they weren't interested in any stories I had to tell about him. Period. This is because, as I now knew, the Pirahãs believe only what they see. Sometimes they also believe in things that someone else has told them, so long as that person has personally witnessed what he or she is reporting. In the end, Everett never converted a single Pirahã. But he did even worse than converting zero people—he lost his own faith after coming to believe that the Pirahã had a good point. After keeping this to himself for many years, he revealed his loss of faith to his family, which led to a divorce and his children breaking contact with him for a number of years afterward. But Everett losing his faith in the God of Abraham was only the beginning. Most importantly for us, he also lost his faith in the God of Linguistics—Noam Chomsky. III. THE WAR In 2005, Everett’s paper “Cultural constraints on grammar and cognition in Pirahã: Another look at the design features of human language” was published in the journal Cultural Anthropology. An outsider might expect an article like this, which made a technical observation about the apparent lack of a property called ‘recursion’ in the Pirahã language, to receive an ‘oh, neat’ sort of response. Languages can be pretty different from one another, after all. Mandarin lacks plurals. Spanish sentences can omit an explicit subject. This is one of those kinds of things. But the article ignited a firestorm of controversy that follows Everett to this day. Praise for Everett and his work on recursion in Pirahã: He became a pure charlatan, although he used to be a good descriptive linguist. That is why, as far as I know, all the serious linguists who work on Brazilian languages ignore him. Noam Chomsky, MIT professor and linguist
Inline links: source, Cultural constraints on grammar and cognition in Pirahã: Another look at the design features of human language
PISA1 mentions across 1 issues

PISA is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between February 18, 2021 and February 18, 2021. The archive places it in contexts such as "make the US rocket up the PISA rankings". It most often appears alongside American education, Appalachian, Baby Einstein.

Reference entry
PISA
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1
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1
First seen
February 18, 2021
Last seen
February 18, 2021
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Book Review: The Cult Of Smart
February 18, 2021 · Original source
He argues that every word of it is a lie. American education isn't getting worse by absolute standards: students match or outperform their peers from 20 or 50 years ago. It's not getting worse by international standards: America's PISA rankings are mediocre, but the country has always scored near the bottom of international rankings, even back in the 50s and 60s when we were kicking Soviet ass and landing men on the moon. Race and gender gaps are stable or decreasing. American education is doing much as it's always done - about as well as possible, given the crushing poverty, single parent-families, violence, and racism holding back the kids it's charged with shepherding to adulthood.
Inline links: match or outperform, has always scored near the bottom of international rankings
And we only have DeBoer's assumption that all of this is teacher tourism. Success Academy itself claims that they have lots of innovative teaching methods and a different administrative culture. If this explains even 10% of their results, spreading it to other schools would be enough to make the US rocket up the PISA rankings and become an unparalleled educational powerhouse. I'm not claiming to know for sure that this is true, but not even being curious about this seems sort of weird; wanting to ban stuff like Success Academy so nobody can ever study it again doubly so.
PISA rankings1 mentions across 1 issues

PISA rankings is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between February 18, 2021 and February 18, 2021. The archive places it in contexts such as "America's PISA rankings are mediocre". It most often appears alongside American education, Appalachian, Baby Einstein.

Reference entry
PISA rankings
Mention count
1
Issue count
1
First seen
February 18, 2021
Last seen
February 18, 2021
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Source context
Book Review: The Cult Of Smart
February 18, 2021 · Original source
He argues that every word of it is a lie. American education isn't getting worse by absolute standards: students match or outperform their peers from 20 or 50 years ago. It's not getting worse by international standards: America's PISA rankings are mediocre, but the country has always scored near the bottom of international rankings, even back in the 50s and 60s when we were kicking Soviet ass and landing men on the moon. Race and gender gaps are stable or decreasing. American education is doing much as it's always done - about as well as possible, given the crushing poverty, single parent-families, violence, and racism holding back the kids it's charged with shepherding to adulthood.
Inline links: match or outperform, has always scored near the bottom of international rankings
And we only have DeBoer's assumption that all of this is teacher tourism. Success Academy itself claims that they have lots of innovative teaching methods and a different administrative culture. If this explains even 10% of their results, spreading it to other schools would be enough to make the US rocket up the PISA rankings and become an unparalleled educational powerhouse. I'm not claiming to know for sure that this is true, but not even being curious about this seems sort of weird; wanting to ban stuff like Success Academy so nobody can ever study it again doubly so.
pituitary dwarfism1 mentions across 1 issues

pituitary dwarfism is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between July 12, 2024 and July 12, 2024. The archive places it in contexts such as "used as a treatment for pituitary dwarfism". It most often appears alongside 1980s, 1989, 1990s.

Reference entry
pituitary dwarfism
Mention count
1
Issue count
1
First seen
July 12, 2024
Last seen
July 12, 2024
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Your Book Review: The Family That Couldn’t Sleep
July 12, 2024 · Original source
(This report was, as it happens, published in the exact same month as The Family That Couldn’t Sleep.) DTM came to know the family well. He befriended them by way of two members of their younger generation, Lisi – a woman terrified by the shadow of the disease, and Ignazio – the doctor she had married, who was more terrified by the shadow of the disease. Ignazio put together the pieces of the family puzzle, consolidating all the disparate diagnoses into a single disorder and filling out a lot of blank spots on family trees. When DTM came along, he was able to help Ignazio make the case that the family would benefit from the spotlight – that greater awareness of FFI could lead to a cure both for them and for a slew of other prion diseases. As it so happens, he is one of those nonfiction authors who serve as a character in their own story. DTM has some form of progressive muscular palsy. He is, or at least was in 2006, not entirely sure what it is. The relatively unimpressive state of genetics at the time had not identified his causative mutation, though it looked a lot like one of the rarer forms of Charcot-Marie-Tooth disease2. DTM is pragmatic about this, the way everyone chronically ill is either pragmatic or doomed. Whatever he has, it is a defect in protein structure; his peripheral nerves decay not because of a problem with the nerves themselves but an inability of their scaffolding to hold them together, as he puts it. The last chapter of the book dwells on this, on the web of connections popping up between a thousand disorders. DTM’s disease is something vaguely similar, if you squint, to an exceptionally slow-progressing motor neurone disease; if you jump another level out, you see amyloid plaque diseases like Huntington’s and Alzheimer’s, and if you jump yet another level out, you see something like prions. His interest in the Venetian family was driven by this. Some of its members thought this a beautiful act of sympathy; others thought him a grotesque parody of themselves, an onlooker, a gawker, peddling their tragedy to salve his relatively insignificant problems. They are, he thinks, both right. That’s the beginning, and that’s the end. What happens in the middle? --------------------------------------------------------- The Venetian family lends the book its title, but they’re really more of a framing device. The Family That Couldn’t Sleep is separated into four parts, of which the first and fourth – the shortest by far – deal with the family. Part 2 is kuru, the king of fucked up diseases you read about in clickbait Weird Medicine listicles. Let’s talk about kuru! Kuru, is, famously, the prion disease you get if you eat another person’s brain. Well, not quite. It’s a prion disease that became endemic amongst women in the Fore society, who ritually ate brains, one of which had an inherited or spontaneous prion disease. This is an important note – there’s a tendency (which the book’s later chapters engage in) to assume cannibalism just has a Prion Disease Generator attached. If you eat people who don’t have prion diseases, you won’t suddenly get one. Uh, don’t eat people. Anyway, part 2 is DTM’s historiography of Fore-Westerner first contact. It’s hilarious. Papua New Guinea is a frankly ridiculous place; one of the all-time best Lyttle Lytton winners (worst first sentence from a hypothetical or, in this case, real work) was “Papua New Guinea is so violent that more than 820 languages are spoken there”. The native residents were so hostile to outsiders that all the colonial empires had cut their losses – and when you think about the places they colonized, that says something. After the First World War, PNG was ripped from its nominal German ‘owners’, but no one else wanted the place. So, of course, they gave it to the Australians. It was thirty years and another war before we actually made contact. 1940s Australia was as ‘settled’ as it’d ever be; the cities were bustling and the interior was mapped. The kind of explorer who two centuries before would be heading to new continents had to console himself with Pacific islands. Console he did. The native peoples of the PNG coasts were hostile enough to the wannabe-colonialists that the Australians, flying planes overhead, were the first people to discover that the island’s inland was populated too. No one had broken through on land. In all this deep and angry rainforest, the Fore were the furthest out. They lived far into the island’s mountainous interior; DTM describes their territory as “nearly vertical”. Calling people primitives is a bit passe these days for understandable reasons, but no other term comes to mind. The Fore had no name for themselves; we call them by an exonym, “the people to the south”. They weren’t, to be clear, hunter-gatherers – they were slash-and-burn agriculturalists, but very well-fed ones. Despite the tendency in grain-focused cultures for poor agriculturalists to be stunted/malnourished, the Fore were a remarkably healthy people. Well, except for the famous bit. The first remarkable thing about the Fore was just how quickly they wanted to assimilate. Most PNG tribes weren’t particularly enthused by Western offers of injections/tractors/radios/Christianity. Yet as soon as the Australians arrived, the Fore made ceasefires in their wars with other tribes, volunteered to help large-scale Australian projects on the coast, started planting and trading coffee, and enthusiastically participated in censuses. It’s the only first-contact narrative I’ve seen where the colonizers were concerned about how badly the other guys wanted to be colonized. The next was the one that got their names in the history books. Australian officials started to notice a remarkable lack of women in Fore camps. Some tribes sequestered their women, particularly when Westerners were around, so at first they thought nothing of it. The high rate of unpartnered young men, though, was way out of PNG norms. DTM tells this part fantastically. The Fore chapters drip with the dread of dramatic irony. When the first breakthrough comes, you have to catch your breath: “Tiny” Carey noted something in the middle of August 1950 that deepened this mystery. He noticed that near the village of Henganofi there had been an unusual number of deaths. “It appears,” he wrote his superiors, “natives suffer from stomach trouble, get violent shivering, as with the ague, and die fairly rapidly.” [...] McArthur investigated a little more [...] One day in August 1953 he ran into more of the shivering people Tiny Carey had seen several years before: “Nearing one of the dwellings, I observed a small girl sitting down beside a fire. She was shivering violently and her head was jerking spasmodically from side to side.” It would be quite some time before anyone figured out what caused it – but the problem, as DTM notes, was that its cause wasn’t possible. Everyone priored that the weird undescribed disease in the Fore lands was some nocebo sorcery-sickness. Vincent Zigas, the first actual doctor sent to work with the Fore, tried to placebo-effect them and failed miserably: On the way, Apekono stopped at a hut and showed Zigas his first kuru victim. “On the ground in the far corner sat a woman of about thirty,” the doctor wrote. “She looked odd, not ill, rather emaciated, looking up with blank eyes with a mask-like expression. There was an occasional fine tremor of her head and trunk, as if she were shivering from cold, though the day was very warm.” It was almost exactly the tableau McArthur had witnessed in 1953. Zigas, though, was a doctor. He could do more than look—or so he thought: “I decided I might as well try my own variety of magic,” he remembered. He rubbed Sloan’s Liniment, a balm for sore muscles, on her and declared to her family and his guide: “The sorcerer has put a bad spirit inside the woman. I am going to burn this spirit so that it comes out of her and leaves her. You will not see the fire, but she will feel it. The bad spirit will leave her and she will not die.” The lotion penetrated the woman’s skin and she writhed in pain. “Get up! Walk!” Zigas commanded theatrically. “The woman struggled feebly as if to rise, then, exhausted, started to tremble more violently, making a sound of foolish laughter, akin to a titter.” That evening Apekono asked Zigas not to try to cure any more kuru victims; “Don’t use your magic medicine anymore. It will not win our strong sorcery.” This was a disaster. The Fore were so cooperative precisely because they hoped “Western magic” could conquer theirs. As it became clear it couldn’t, they turned hostile. The Australians had hoped to “modernize a Stone Age people”; now all their subjects were dropping dead before their eyes, from what they could only assume was a “hysterical reaction” to colonization itself. So, to solve this, they needed a batshit insane American. Carleton Gajdusek is one of the characters who dominates The Family That Couldn’t Sleep. He couldn’t not. You could put him in a car commercial and he’d dominate it. Gajdusek was a physician with a rare, intense combination of science and practice. He was a romanticist, a field worker, and a lover of everything strange. He’d been an army doctor, a government conspiracy-cover-upper, and a postdoc under Linus Pauling who described his intent as “to straighten out Pauling’s ideas about proteins”. He hated civilization, in a slightly-to-Ted’s-centre sense, and was passionate about “primitives and isolates”. He jumped at the chance to work in Papua New Guinea; he planned to conduct a multi-site study on child development in such cultures, and relished the opportunity to live in a “primitive” environment himself. He did all this so he could rape kids. Oh, he did it for the scientific curiosity and love of medicine, but he also did it so he could rape kids. Gajdusek was a pedophile in the actual-lifelong-exclusive-paraphilia sense, as opposed to the “metonym for child molester” sense. Some people who roll snake-eyes on the Sexuality Dice repress it, but some are perfectly happy to act on it; Gajdusek was #2 in its fullest form, the kind of guy who believes that a well-lived life includes raping some kids. DTM doesn’t shy from this, not for a moment. It’s the first thing he tells you about Gajdusek. It couldn’t not be; you couldn’t talk about why he went to PNG otherwise. When Gajdusek landed in PNG, he first found the place too civilized. He’d been promised a land of “cannibal savages” – where were they? After some traipsing, he found them, right where he was promised. The Fore were perfect for Gajdusek. They had some kind of medical mystery that’d been lost on everyone else. They ate each other, in exactly the way he loved detailing in his diaries (“”Women and children, particularly, partake of the human flesh,” he noted with pleasure”). As kuru cases popped up, he aggressively recorded them. He wrote lovingly detailed notes that he sent back to his Australian advisor. He wrote with intensity, with exclamation marks, with the joie de vivre of a man just where he wanted to be. Gajdusek smothered the Fore with ‘cures’ that never worked, but they didn’t get angry at him. As DTM dryly puts it: “Their children trusted him, and that was enough for them.” At some point, someone suggested sending an anthropologist...or an epidemiologist...or literally anyone with more credentials than Gajdusek and Zigas3. Gajdusek threw a shitfit, convinced this one-and-a-half-man team was enough to Solve The Problem Forever. But he got bored eventually – running off with another tribe with, as his diary notes at length, an apparent custom of youths ritually fellating older men – and Zigas, I dunno, the book neglects him a bit here. So they managed to sneak in some anthropologists. The husband-and-wife team of Robert Glasse and Shirley Lindenbaum4 were the first involved parties to give a shit about the Fore as people, rather than as colonial subjects/medical mysteries/walking sex toys. What they uncovered was fascinating. The Fore were cannibals, yes, but they were recent cannibals. They didn’t have an ancient tradition of eating their dead, like the other visitors assumed. They happened to be in contact with some cannibal groups, and after a Fore man died of “sorcery”, they thought: well, what would happen if we ate him? “People tasting it expressed their approval. ‘”This is sweet,” they said, “What is the matter with us, are we mad? Here is good food and we have neglected to eat it.”” If not for the wild coincidence that the first Fore cannibalism victim had a prion disease, kuru would never have existed. Glasse and Lindenbaum started to put together the pieces. They’d been sent down to rule out a genetic explanation – to track the kinship ties of the Fore and see how the disease ran through families. It didn’t run through families in any coherent sense, but it sure did run through cannibalism. The clincher was the age distribution. The Fore, ever enthused by colonialism, quit eating each other as soon as the Australians arrived. Children stopped dying of kuru shortly after; they simply weren’t exposed to the infectious agent. The couple sent the news to Gajdusek, who was off raping kids somewhere else. In the next part of the book, DTM runs through Gajdusek’s many conjectures of kuru’s cause – more like sketches or abstract paintings than like true hypotheses. Gajdusek was annoyed that someone else was doing something he “totally could’ve done”, and even more annoyed that another lab was running similar experiments – an attempt at a vaccine for a particular sheep disease had accidentally created a prion generator. But he was happy to swoop in and claim the credit for what he was starting to think of as “slow viruses”, an infection that somehow lays dormant for years. DTM portrays Gajdusek perfectly, in that “real life has no need for verisimilitude” way. Gajdusek was at once a brilliant man, an all-consuming narcissist, an entertaining character, and a monster beyond redemption. A lesser book might pick one or two. The Family That Couldn’t Sleep portrays him as all four, and on a personality level (as opposed to a scientific one), the Gajdusek-focused parts are some of the most gripping. --------------------------------------------------------- Outside of the jumps between the Venetian family and everything else, The Family That Couldn’t Sleep is not siloed. The narratives of all prion diseases are deeply intertwined. This is what makes it a great book. It’s 300 pages of dramatic irony. You read the whole thing, waiting for the eureka moment – the point everyone realizes they’re looking at the same cause. It does, however, make it a tad difficult to review or synopsize. The book’s story is so weird – and, often, so at odds with conventional wisdom that trickles down about the Fore et al – that you have to recap quite a bit, and the book steadfastly resists recapping. The next couple chapters after we depart from Gajdusek’s credit-claiming are mostly about experiments with various prion diseases. They’re scientifically fascinating. Unlike some medical-books-for-general-audiences (cough, How Not to Study a Disease), DTM never talks down to the reader. He assumes someone reading a 300-page book about prions is smart and wants to learn about prions. He also has – you can feel it in his words – the agonizing experience of spending his life on the other side of the doctor’s desk, trying to beat into whoever he’s talking to that no, seriously, you don’t need to lie to him or try explain a complex disease at a fourth-grade level. The first prion disease studied was scrapie. Scrapie was a big deal – it starved and killed large shares of British sheep flocks, making it a serious economic problem. Veterinary researchers had tried to prevent or cure it for centuries. It was a veritable graveyard of ambitions: Quintessential was D. R. Wilson at the Moredun Institute in Scotland, who worked in the middle of the last century for more than a decade trying, with mounting frustration, to kill the scrapie agent. He found that it survived desiccation; dosing with chloroform, phenol, and formalin; ultraviolet light; and cooking at 100 degrees centigrade for thirty minutes. The scrapie researcher Alan Dickinson told me he remembered Wilson at the end of his career as “very, very, very quiet. Of course, that was after his breakdown.” “Now it is our turn to study prions. Perhaps we should approach the subject cautiously.” The problem, as DTM explains, is that prion diseases were impossible. They violated 20th-century understandings of biology. Proteins “were no more alive, and no more infectious, than bone”. Prion diseases seemed to have too many causes – genetic, infectious, and sporadic. They looked infection-like in some ways, but patients didn’t produce virus antibodies. Sheep exposed to scrapie, or chimps infected with kuru, took years to develop symptoms. Their facts did not fit together. In the 1960s, people started wondering. The unifying trait of prion agents was that they had to be denatured to be destroyed. Was this a particularly small virus defined by its protein coating? Or – even more outre – was it pure protein, no DNA at all? No one could figure out quite how the latter worked, but it was tempting. Gajdusek, by now a major figure in this field, kept a foot in both worlds. He didn’t want to stake his reputation on a no-DNA hypothesis, but he certainly sympathized. Enter Prusiner. Stanley Prusiner was Gajdusek’s counterpart. Where Gajdusek seemed permanently manic, Prusiner was deliberate and exacting. He entered Gajdusek’s “slow viruses” field in the early 1970s after a chance encounter with a CJD patient. He relished the laboratory in a way Gajdusek didn’t at all, and set out to optimize the hell out of his projects. Prusiner set out to isolate the smallest infectious particle in the scrapie agent. He injected tons of hamsters (hamsters got sick faster than mice) with increasingly tiny scrapie proteins, hoping to determine whether the Minimum Viable Scrapie was DNA. By the mid-1980s, he’d produced something so small it couldn’t possibly be a virus. Denaturing it destroyed it; exposing it to nucleic acid dissolvers actually made it stronger. Emboldened by this discovery, Prusiner set out to anoint himself the King of Prions. Here emerges something of a Voldemort-Umbridge distinction – the difference between cartoonish villainy and banal evil. Gajdusek is a bad guy because he rapes kids. Prusiner is a bad guy because he is the most grotesque stereotype of the Advisor/Peer Reviewer from Hell made flesh. Everything Prusiner did was to build his reputation atop a pile of skulls. When recruited as a peer reviewer for other prion papers, he wrote negative reviews to undermine their authors. He worked his grad students to the bone and intentionally destroyed their careers, telling them he’d “ruin them” if they entered prion research as competitors. He lied about the origin of the protein-only hypothesis, claiming he originated it a decade after it was actually conjectured. But hey, he was good at getting grants. I was surprised reading a lot of this, because for all the time I’ve been aware of it, the cause of prion disease has seemed settled. “Oh yeah, it’s a protein that gets all fucked up.” But DTM goes through just how unsettled it was right up through to The Family That Couldn’t Sleep’s publication. Serious confirmation only arrived a couple years later. Many people were deeply critical of the prion hypothesis – often, it seemed, because they loathed Prusiner too much to go along. Throughout the book, he cuts an uncharismatic figure. Gajdusek and Prusiner both won the Nobel for discovering prions, decades apart. This tells you something – the “discovery” of prions can be construed quite a few ways. Gajdusek formulated the hypothesis; Prusiner proved it. Gajdusek was grievously offended by Prusiner’s Nobel, perceiving his rival – not inaccurately – as a follower who never originated any ideas of his own. But Gajdusek was offended from a federal prison cell, so how’d that work out for him? Fascinating as all this is, no one published a book about prions in the mid-2000s because it was about kuru or FFI. They published books about prions because teenagers were dying, and people wanted to know why. DTM lays the seeds for part 3 – the mad cow section – in part 1. This is a discussion of scrapie, the longstanding prion disease of sheep. Scrapie was a medical mystery for centuries (remember poor D. R. Wilson), precisely because of the intuitive implausibility of prions. The scrapie chapter is a great history-of-science piece, covering the agricultural productivity revolutions of the 18th century, the surfeit of bizarre origins veterinarians concocted, and the treatments that never worked. Scrapie is not transmissible to humans – well, we hope. It’s concerningly transmissible to primates. But it’s been around for a long, long time, and it doesn’t epidemiologically look like humans get it...we hope. Anyway, you ever tried to generalize from one example? The British government did! In the mid-1980s, strange reports started coming out of the UK’s farms. Farmers were describing a new disease where dairy cows – incredibly docile creatures, under normal circumstances – turned hostile, kicking them as they went into the milking stalls. The symptoms looked to all the world like scrapie. Epidemiologists tracing the outbreaks found a unifying link with “cake” – animal protein feed sweetened with molasses. The scrapie-like symptoms must have traced to an infected sheep. But scrapie doesn’t transmit to humans, so it must be okay to keep slaughtering them, right? We all know how this ended. The best term for the British response to the mad cow outbreak is “cacklingly evil conspiracy”. The agricultural industry really, really didn’t need a huge zoonotic outbreak – so it decided it didn’t have one. They first suppressed all mentions that the disease looked like scrapie, then – when this became impossible – hyped up that scrapie doesn’t transmit to humans, so there’s nothing to worry about. The formal name of the disease, “bovine spongiform encephalopathy”, was supposedly chosen to optimize for unfamiliarity – it wouldn’t fit well in a headline. They emphasized, extensively, that there was nothing to worry about. Ever. At some point, people started asking questions. If there was nothing to worry about, why was the agricultural industry panicking so hard? As things became ever more worry-inducing, this turned down ludicrously twisting paths: Meanwhile, the Southwood Working Party and the experts who advised it were learning on the job. They learned, for instance, that the BSE agent entered the animal through the mouth and then followed the digestive tract into the organs that try to filter out infections—the tonsils, the guts, and the spleen—and from there traveled into the peripheral and central nervous system, and finally arrived at the brain. They also learned that pasties, meat pies, and even some baby foods contained tissues from a lot of those organs. So the Southwood Working Party recommended banning these organs, but only from baby food. This started a chain reaction of consumer doubt: if infected cow organs were unsafe for babies, how could they be good for adults? The government then banned offal, as the organs were collectively called, in all human food but gave the industry a grace period to get it out of the feed supply. Then pet food manufacturers began to wonder if what drove cows mad might not also drive dogs, cats, and parrots mad. The feed they sold came from concentrate made of the same sick animals that had previously made up the meat and bone meal farmers used. Their trade group decided to put a similar ban in place—immediately. So for five months it was safer to be a dog than a human in Britain. DTM spends pretty much this whole section of the book making fun of the British government. To be fair, they deserved it. They killed hundreds of kids in agonizing and preventable ways – they could take some ribbing. This is all throughout the mid-1980s to early-mid 1990s. Through this period, it wasn’t yet clear that mad cow could spread to humans. The panic was clear, and deserved, but it didn’t yet have a match for its powder keg. It would alight. The first suspected case of vCJD – human mad cow – was in 1994. Fifteen-year-old Vicky Rimmer developed a sudden, strange disease. Doctors gave her months to live...until she died in 1998. A couple other suspected cases trickled down through the mid-90s, including a young man who made meat pies for a living, whose grieving mother received a letter from the Prime Minister that “humans do NOT get mad cow disease”. (That must’ve been fun.) Soon, they couldn’t deny it any longer. On March 20, 1996, Stephen Dorrell, the health secretary, stood up in Parliament to announce the news that had already appeared as a tentative conclusion in scientific journals and as rumor in newspapers for the previous two years: British beef was killing British teenagers. The first confirmed death was that of Stephen Churchill, a nineteen-year-old student from Wiltshire, who died in May 1995. Back in 1989, at the Southwood Working Party’s suggestion, the government had set up a surveillance unit in Edinburgh to watch for any evidence that BSE had crossed to humans. One worry had been that if BSE passed to humans, how would anyone know it? How would you recognize something you had never seen? It turned out to be easy: Churchill and the nine other teenagers who had gotten sick had spectacular amyloid plaques in their brains, chunks of dead protein almost visible to the naked eye. If sporadic CJD was a whisper, BSE-caused prion disease was a shout. The investigators sat open-mouthed looking at slides whose damage, they feared, portended the most severe epidemic in modern British history. This part of the book is not fun. It lacks the insane personalities and duelling careers of the other entries. It is an honest chronology of the vCJD epidemic – a gruesome failure of the agricultural industry, the one system that everyone is vulnerable to. The government and industry had completely violated their duty of care to citizens and consumers. They were paying the price. No one would buy British beef anymore – not while they watched their children die. Now here’s the thing: this is ethnography, not historiography. The Family That Couldn’t Sleep is a book from the mid-2000s. The epidemic was not at all in the rear view mirror. There were piles of unanswered questions that DTM constantly alludes to. We have eighteen years more hindsight than he did then. What do we know now? --------------------------------------------------------- In 2006, the vCJD epidemic looked like it was going to be a lot better than the worst fears. BSE itself was a huge problem for the cattle industry, but honestly, no one is too sympathetic to the cattle industry. People were not going to die in anywhere near the numbers believed. We had all sorts of reassuring data coming out about this, which DTM chronicles. We were learning that only some genotypes seemed susceptible to vCJD. We didn’t see any older people die of the disease. We were seeing numbers drop, such that vCJD must have a pretty short incubation period. Anyway, all of this is wrong! The Family That Couldn’t Sleep was written in the candidate gene era. Back then, the nascent field of human genetics was sure it was about to Solve Polygenism. Yes, the simple Mendelian monogenic patterns popular a few decades back clearly didn’t apply to common diseases, but how many variants could there be? We were about to discover the five genes influencing 20% of Alzheimer’s risk each, the five genes influencing 20% of heart disease risk each, etc., and once we were done we’d just do gene therapy and cure Alzheimer’s. A paper on autism genetics from 1999 was so outre as to speculate there might be as many as fifteen genes involved. The fact we are now using the term “omnigenic model” should tell you roughly how well this worked out. Do you remember SNPedia? If you were a 2014 Slate Star Codex reader, you might. 2014 was still pretty candidate gene. People were out there publishing papers saying a single variant could increase your life expectancy by 15 years. SNPedia was a site that beautifully categorized all of these, so you could do 23andme or whatever, look up your results on SNPedia, and make horrible life choices.5 It was eventually bought out by one of the consumer DNA companies, so no one ever edited it again, making it a great time capsule of early-mid 2010s behavioural/medical genetics takes. SNPedia will excitedly explain to you that common genetic variants make you immune to vCJD. They cite a 2009 post from the now-archived 23andme blog titled “No Good Evidence That Potential Pool of Mad Cow Disease Victims Is Expanding”, explaining how fears of late-onset vCJD are clearly debunked by new Scientific Knowledge. Everyone who developed vCJD in the 1990s and 2000s had an M/M genotype in a particular part of the PRNP prion gene, so the roughly half the population with M/V or V/V genotypes were immune. The Family That Couldn’t Sleep buys this, too. In fact, it buys it in an even more agonizingly 2000s way. The first sign that transmissible prion diseases weren’t genotype-restricted should’ve been the growth hormone kids. You might have heard this story – from the late 1950s through mid-1980s, human growth hormone produced from brain tissue was used as a treatment for pituitary dwarfism, until it turned out to spread CJD if the originating brain was infected. DTM discusses this, to set the scene for the genetics thing. He mentions what was the state of the art at the time – that a disproportionate share of both the growth hormone kids and sporadic CJD cases were V/V homozygotes. This, uh – so the book was written in the mid-2000s, yeah? Yeah. The conclusion DTM drew – and this was a common conclusion at the time – was that homozygosity somehow made you more vulnerable to CJD, and M/M homozygosity made you vulnerable to BSE-borne CJD in particular. We cannot criticise the author for not predicting the future, but we live in the future, and can say how this worked out. Turns out, nope, M/V heterozygotes totally get vCJD. After a British man in his 30s died of CJD in 2016, he was found to have vCJD and an M/V genotype. He was tested for vCJD only because he was exceptionally young for someone with a sporadic prion disease – meaning people developing it later in life would be missed6. Did you know up to 1 in 2000 people in the UK have latent vCJD? There is one line in The Family That Couldn’t Sleep that stopped me dead in my tracks when I read it: What happens to the Italian family in the end depends less on their own actions than on the world’s interest in prion diseases, which they cannot control. If lots of people are afraid of getting variant CJD, the family benefits. If fear of prion disease goes the way of the fear of swine flu or Ebola, then they will be orphaned again. THIS BOOK IS FROM 2006! Three years before the swine flu pandemic! Eight years before the Ebola pandemic! “If you’re looking for a sign, this is it.” --------------------------------------------------------- The last section of The Family That Couldn’t Sleep addresses BSE fears in America and a nascent internet subculture DTM calls “Creutzfeldt Jakobins” – people who track American CJD cases, trying to spot vCJD patterns. When reading his description of the Creutzfeldt Jakobins, my mind constantly, uncontrollably turned to covid. Here it was – an online community of people deeply skeptical about a disease’s official story, tracking every contradiction, every implausibility, every statistic that failed to apply to the individual. Self-described “redneck hippies” and “soccer mom Republicans” teaming up to find the truth hidden behind an impossible world. You know what they’re doing now. I’ve always combined a deep interest in medicine with a healthy distrust for it. People who are constitutionally inquisitive, anti-authoritarian, and suspicious about official narratives tend to end up skeptical of at least some mainstream claims in the field. This is not to say I think you should take bleach enemas or something, just that I understand the impulse behind concluding the US government was covering up a local vCJD wave. Traditionally, sporadic prion diseases are said to have a prevalence of one in a million. (Hold on to that for a second.) The last section of the book is a chronology of Americans finding bizarrely more than one in a million of their friends dying of sporadic CJD, often at inexplicably young ages, sometimes in geographical clusters. This is understandably suspicious. Then DTM goes on to reassure us by saying none of these cases were confirmed to have an M/M genotype, which OH GOD OH FUCK A number of high-profile people in the prion world, including Gajdusek, are clarified as not believing sporadic prion diseases exist. You get the impression DTM doesn’t, either. Now, how common are prion diseases? Eric Vallabh Minikel has an answer for you! Eric and his wife Sonia are prion researchers from a rather unique background – after Sonia was diagnosed as having a single-gene mutation with ~100% penetrance for prion disease, they left their previous jobs to dedicate their lives to curing it. It turns out, when you run the numbers, you get not one in a million but 1 in 5000 people dying of prion diseases. This is best described as “nightmarishly high”. I’m normed on genetic disorders. A genetic disorder that affects one in five thousand people is pretty common! I have known, in person, completely unselected, just from “random people I’ve met in my life in a non-medical context”, someone with a ~1/250k syndrome and someone with a ~1/50k-100k syndrome. I don’t think anyone in my extended family knows someone who died of a prion disease. I feel like it would’ve come up if they did! Prion diseases have distinctive phenotypes. Not distinctive enough, apparently, to avoid a lot of CJD being misdiagnosed as Alzheimer’s – but diagnosis is consistently insane. Something DTM reiterates throughout The Family That Couldn’t Sleep is just what prion dementia looks like. The characteristic dementia in prion diseases spares something – “self” or “recognition” or “reflection” – that is not spared by Alzheimer’s, or by most common dementias. Shouldn’t this be, uh, noticeable?7 They kill rapidly, often over the course of months, and often onset in midlife. ALS shares this pattern and is way, way more common than prion diseases; you hear about ALS far more in the “disorder people actually have” sense. What am I missing here? Anyway: 1 in 2000 prevalence of latent vCJD in the UK + extreme lack of clarity over whether scrapie is human-transmissible + blood donations spread vCJD + sporadic CJD prevalence keeps going up = ??? (Yes, I am annoyed that most countries have lifted their ban on UK blood donors, thank you for asking!) --------------------------------------------------------- But back to the book. The “American chapter” is one-third about the country’s response to vCJD, one-third about the Creutzfeldt Jakobins, and one-third about chronic wasting disease. The last part is the most interesting. Chronic wasting disease is a prion disease of deer. Like scrapie, it “probably, we hope” isn’t human-transmissible (eat venison at your own risk). Under natural circumstances, deer shouldn’t get prion diseases: A prion plague should not be possible among ruminants in the wild. Deer are not cannibals, as the cows that spread BSE were forced to be; and, because deer and elk are not domesticated, they do not have enough contact with one another to spread a prion infection the way sheep are thought to spread scrapie. But deer do not live as they used to live, humans having once again brought their ambitions to bear on the natural course of things. The Family That Couldn’t Sleep is a book of medical anthropology. Anthropology of the Veneto, anthropology of Papua New Guinea, anthropology of 1990s Britain. Here, it is an anthropology of America. Americans, having won the world, still fight to win their own backyard. The North American continent is geographically diverse, cutting through rain-snow-shine, mountains jutting over plains, cities sprawling into wilderness, habitations criss-cross dotted with surprisingly few empty zones. Go somewhere like Denver, the Mile High City, three million people fighting against nature. Few other countries have anything like this; geographically vast polities usually have uninhabitable blocks. Australians are twenty-five million people clustered against the shore. It still surprises me, after all this time, how every US state has a meaningful city8. Midcentury Denver, growing and sprawling out across its mountains, started to run into their natural inhabitants – deer. Starvation is one way nature adjusts the deer population to the available food supply. People did not usually see this process, but in the 1950s and 1960s Colorado became more densely settled, reducing forested areas and forcing deer to look longer and harder for food. At the same time, the state enacted conservation laws, limiting when and where hunters could shoot. Soon emaciated deer began wandering onto the lawns and through suburban streets looking for a meal. People began to feed them, only to find that they died anyway. They would drop dead by haystacks, along highways, and in flower beds. In the late 1960s, a young biologist named Gene Schoonveld tried to figure out why the deer starved even when they were fed.9 He deprived some deer of food for a while, “[h]e cut windows in their stomachs to see what went on inside, and then he began to feed them”. While this was going on, he had a control group of healthy, well-fed deer as backups in case anything went wrong. It did...but not to the experimental group. The pen in which the deer were kept also housed sheep, which, it turned out, were scrapie carriers. The deer somehow acquired scrapie – there’s a huge unanswered question here, which DTM doesn’t address. How did they get scrapie? They didn’t eat the sheep, presumably. Did it somehow transmit from casual contact? This is not supposed to happen. And yet: the deer in the sheep pen started dying of a mysterious scrapie-like disease, one never reported before, that would go on to infect thousands. These deer were released into the wild. Ten years later, the first reports of chronic wasting disease came out. The disease spread across deer and elk in the western half of the country. By the turn of the millennium, cases were exploding – and lost all geographical restriction. DTM can report up to 2005, at which point it was floating around Upstate New York. This kind of spread doesn’t track natural deer migration. That’s irrelevant, because nothing about CWD’s spread is natural. We shift gears into an anthropology of the American hunter. The hunter wants to shoot the most impressive buck, to bag himself one with as many “points” as possible – one whose antlers branch out most. A “ten-point buck” has five branches on each horn: Original by Ric McArthur Nature doesn’t make enough bucks with perfectly symmetrical ten-point horns. To fill the demand, the market had to step in. Thus was born the deer farm industry, which raises captive deer in better genetic and nutritional conditions than Nature permits, then ships them across the country so hunters who couldn’t get legit ten-point bucks get the taxidermy piece for their wall. These are controversial amongst hunters and illegal in numerous states – but the industry is big enough to spread CWD. (The kind of hunter who needs a deer shipped to his house is the kind of hunter who will fumble killing it.) Another problem is supplemental feeding – leaving out protein-enriched food for deer to eat. This produces “trophy class animals at an earlier age”, but again, what’s in that protein? (“It is much like feeding your cows 41 percent protein cottonseed cake during the winter to raise the protein level in the cow’s diet to a level that will maintain acceptable production”, says that article from 1991.)10 The book segues into a vignette. CWD was new in Wisconsin in the early 2000s, and the state’s Department of Natural Resources was optimistic it could eradicate it. In a state with a love of hunting, you could, in theory, recruit people to kill every single deer in a 400-square-mile radius: In many states, the state would have had to call out the National Guard for such an onslaught, but hunting is a passion in Wisconsin. Hunters shoot 450,000 deer every year, more than in any other state. “I’m looking for ardent hunters to help us, unless fear or their wives keep them away,” one DNR official told a Milwaukee magazine. The state extended the normal hunting season and waived the usual limit of one buck per hunter, and the hunters came out in force. The whole affair was gruesome – one official called it “hunting for slob hunters”. If you’re trying to eradicate a prion disease, you can’t very well let people take the carcasses home to eat. Bodies piled up in control stations, decomposition mingling with bleach. The 2002 hunt established a base rate of 2% for chronic wasting disease in Wisconsin deer, with the most affected areas getting up to 10%. Further hunts in 2003, 2004, and 2005 spread to wider and wider areas – and didn’t move the needle one bit. This is to say that CWD is quite a bit more common in the American deer population than BSE ever was in British cattle. Since publication, it’s popped up in Norway and South Korea. Notably, Norway doesn’t allow for the import of cervids, raising numerous questions about how it got there. There are no unambiguous cases of CWD transmission to humans, and in vivo/in vitro primate studies have mixed results. There sure are some unusually young hunters with sporadic CJD, though. But don’t worry, most of them aren’t M/M homozygotes! There is an absolute ton going on in this book. I’ve had to skim over whole sections. Parts that couldn’t be easily slotted into a narrative review include: When Gajdusek was invited to a party at Prusiner’s house, he was horrified to find his rival had purchased hundreds of New Guinean statues – all with the genitals removed.
Inline links: 2, Lyttle Lytton, 3, 4, a couple years later, concerningly transmissible to primates, omnigenic model, you might, 5, SNPedia, a 2009 post, https://substackcdn.com/image/fetch/$s_!N93S!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fced2eca3-ec58-40b8-8c13-debdb559ab8f_651x601.png, Yeah., nope, M/V heterozygotes totally get vCJD, 6, up to 1 in 2000 people in the UK have latent vCJD, bleach enemas, has an answer for you, 7, blood donations spread vCJD, going, up, 8, 9, not supposed to happen, https://substackcdn.com/image/fetch/$s_!0J8B!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F2a64b287-a7c6-4d82-bbe1-da949fc93118_1024x683.png, Ric McArthur, controversial, amongst, hunters, illegal in numerous states, trophy class animals at an earlier age, 10, Norway, South Korea, mixed results, sure are
pituitary HGH experiments1 mentions across 1 issues

pituitary HGH experiments is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between July 12, 2024 and July 12, 2024. The archive places it in contexts such as "We need to redo the pituitary HGH experiments with more diseases". It most often appears alongside 1980s, 1989, 1990s.

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1
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1
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July 12, 2024
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July 12, 2024
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Your Book Review: The Family That Couldn’t Sleep
July 12, 2024 · Original source
What I’m saying is that we need to redo the pituitary HGH experiments with more diseases My advisor has informed me not to say this.
Pivotal Act1 mentions across 1 issues

Pivotal Act is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between May 13, 2024 and May 13, 2024. The archive places it in contexts such as "Pivotal Act". It most often appears alongside 17 CFR Part 40, 2024 election, Austin.

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Pivotal Act
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1
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1
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May 13, 2024
Last seen
May 13, 2024
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  • 24 May 13, 2024
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24
May 13, 2024 · Original source
Statements by two dissenting CFTC commissioners (1, 2) on why they oppose. Pivotal Act Manifold Markets says they’re pivoting to a new model combining play money points and real-money gambling. Manifold may be a beloved local fixture, but their growth and revenue aren’t too impressive: In the interests of continuing to exist and push prediction markets forward, they will switch to a “sweepstakes” model. Although gambling is illegal in most US states and requires complicated licensing in others, there’s a “sweepstakes loophole”; companies are allowed to offer “prize sweepstakes”, and you can use this to sort of reconstruct the concept of gambling in a legal way. You don’t give the company money and get back money. You pay for “points”, get “sweepstakes tokens” as a bonus, gamble the “sweepstakes tokens”, and then cash in the sweepstakes tokens for money. This is a pretty surprising loophole, but it’s already used by sites like Chumba Casino and Fliff. (and apparently it creates weird incentives! In order to maintain the fiction of being a “sweepstakes”, these casinos have to give you “tokens” if you request them by mail. If you send a postcard to Chumba Casino asking for free money, they’ll give it to you, $5 per postcard. Is this an infinite free money pump? My impression is in theory yes, but the postcards have to be handwritten in a very specific way, the company sometimes rejects them for weird reasons, the cost of materials and mailing lowers your profit to more like $4, and so you’d have to hand-write 250 postcards to make $1,000. I’m still surprised more people don’t do this.) Because real money is involved, Manifold will have to tighten the rules on markets, including banning N/A resolutions. You can see a full list of changes here. Manifold users are split between acknowledging that the for-profit company they love needs some way to make money, being salty about the changes, and being worried that creating more of a casino atmosphere will be bad for users / the world / ability to function as a good prediction market. (I understand most of the NO vote here is based on the theory that there will be legal intervention - maybe because the government is willing to tolerate sweepstakes casinos but not sweepstakes prediction markets). Manifold co-founder Austin Chen won’t be involved. He’s leaving the site - not explicitly because of the pivot, he just said it seems to be “trapped in local optima”. He plans to focus on other parts of the Manifold empire, especially Manifund, which tests impact markets, regranting, and other “experimental” charity models. Manifold will continue in the hands of the other two co-founders, James and Stephen Grugett. Superhindcasting I mentioned this in my lab leak post, but it deserves more attention here: Good Judgment Project’s report on Superforecasting The Origins Of The COVID-19 Pandemic. Good Judgment Project employs superforecasters who will predict things for clients. Some people interested in COVID origins asked them to judge whether lab leak was plausible. Their headline result was 74% zoonosis, 25% lab leak, 1% something else. Part of GJP’s method is getting their forecasters to share sources and talk to each other. Here’s the graph for how that went: People changed their minds a little over time, but not in a very consistent way that mattered much in the end. What was the “client feedback”? The report says: Client feedback was provided to the Superforecasters on December 21. The client posed questions to the Superforecasters about their assessments up to that date and asked for their reactions to several studies and articles. In the days following the client engagement, the Superforecasters lowered their confidence in the natural zoonosis hypothesis from 73% to 67%, although zoonosis remained the most likely potential cause in their assessment. But following an active engagement with recent genomic studies and historical base rates of zoonotic spillovers, those numbers began to return to earlier levels. January also saw increased attention to the geopolitical context and transparency issues, particularly related to research activities in Wuhan Is this bad? I’m imagining a pro-lab-leak client saying “But what about [this list of pro-lab-leak arguments]?” and then the superforecasters read them and adjust. In one sense, it’s good that they got to see more arguments; on the other, it seems like a potential route by which clients could bias the results - probabilities never quite got back to where they were before the feedback, though they got pretty close. The last-minute spike for zoonosis might be the Rootclaim debate results, which were released on 2/18. So maybe the client feedback and the Rootclaim results both slightly affected the numbers, but mostly the superforecasters started out pro-zoonosis and stuck to their guns. Dan Schwarz and the FutureSearch team say that forecasting has a “rationale-shaped hole”. Despite the report making this sound like a pretty intense process, we don’t get much information about details: In their extensive discussions , Good Judgment’s Superforecasters assessed base rates and historical patterns, existing evidence and scientific analysis, geopolitical context and transparency concerns, trust in intelligence communities, and methodological constraints. 1. Base Rates and Historical Patterns: The Superforecasters frequently referenced base rates, i.e., the history of pandemics emerging from natural zoonosis versus the history of laboratory leaks, to anchor their probabilities. For the former, they discussed how the base rates are changing as the climate warms and as expanding human populations push farther into natural environments that previously saw little human presence. For the latter, they acknowledged that it has only been 12 years since the advent of CRISPR gene- editing tools, and the base rate of lab leaks in the short synthetic biology era is not yet well established. 2. New Evidence and Scientific Analysis: Throughout the period, the Superforecasters adapted their forecasts in light of new scientific evidence, including genomic analyses of SARS-CoV-2 and its relation to bat viruses, and the debate over potential laboratory manipulation. 3. Geopolitical Context and Transparency Concerns: The geopolitical implications of the virus’s origins, particularly in relation to China’s transparency and the involvement of international research institutions, played a significant role in the analysis. Concerns over data veracity, and over the political ramifications of determining that the pandemic’s origins were other than zoonosis, were extensively debated. 4. Trust in Intelligence: Commentary on trust in intelligence communities and discussions about the impact of geopolitical biases on the interpretation of evidence illustrated the complex interplay between science, politics, and human behavior in assessing the pandemic’s origins. 5. Methodological Critiques and the Evaluation of Evidence: The Superforecasters engaged in methodological critiques of the evidence base, including the scrutiny of laboratory practices and biocontainment levels [...] In the end, most Superforecasters were in rough agreement on issues like the base rates of zoonotic spillover. Where they most often disagreed was on the interpretation of actions by Chinese officials and whether their actions reflected how an authoritarian government would react in any crisis over which it did not have full control, or whether those actions were indicative of attempts to cover up a biomedical research-related accident that allowed the SARS-CoV-2 virus to enter circulation in China and, ultimately, the entire globe. Probably it would be too much to ask for to get a transcript of all their discussions - then they’d be nervous saying things that might make them look bad to an audience. What would be a good balance between getting more information and not imposing on their time? Forecasting is an unusually legible and easy-to-judge domain. One of the theories of change for forecasting was to use it to identify smart people with good reasoning, then turn them loose on less well-behaved problems. This is one of the first big attempts to do this at scale. How did it work? We can’t tell, because it’s inherently an illegible and hard-to-judge domain. Darn. I don’t know what I expected. Notes From A Local Optimum Austin’s concern - that forecasting has reached a local optimum - is widely shared. We have some good sites: Manifold, Metaculus, Polymarket, GJO, etc - all doing good work. We have good-ish probabilities for a few important questions. Every so often a news source cites them. Sometimes a decision-maker looks at them behind the scenes, maybe. Is this all there is? The FutureSearch team says the next step is to focus on “rationale”. We need to use forecasting not just to get a raw probability, but to explain what’s going on and why we think something. Then instead of just convincing policy-makers to trust forecasts, we can tell them why something is true, or inform their discussions even if they’re not willing to blindly trust a number. Is this a betrayal of the forecasting ethos? The original dream was that instead of a bunch of people giving arguments, we could just test who was right. Now we’re going back to the arguments? People have argued forever; what does forecasting add to that? Well, they add the knowledge that the arguments are from people who have been right a lot before and are incentivized to be right again. Still, it’s not a natural fit. Probably it’s relevant here that FutureSearch’s forecasting AI does a really good job of this by default, in a way humans can’t match. Nuno’s yearly forecasting roundup doesn’t have a single thesis, but the first part is a well-supported complaint that most forecasting sites aren’t good business. They either burn VC money, burn EA donations, or converge towards casinos to support themselves. He gives an honorable exception to Cultivate Labs, which sells prediction market software rather than the results themselves. Open Philanthropy (billionaire Dustin Moskovitz’s EA-aligned charitable foundation) has at least given forecasting a vote of confidence, recently choosing to promote it to one of their main donation areas. Still, they got a lot of pushback on the decision, for example SuperDuperForecasting here: This will be a total waste of time and money unless OpenPhil actually pushes the people it funds towards achieving real-world impact. The typical pattern in the past has been to launch yet another forecasting tournament to try to find better forecasts and forecasters. No one cares, we already know how to do this since at least 2012! The unsolved problem is translating the research into real-world impact. Does the Forecasting Research Institute have any actual commercial paying clients? What is Metaculus's revenue from actual clients rather than grants? Who are they working with and where is the evidence that they are helping high-stakes decision makers improve their thought processes? Incidentally, I note that forecasting is not actually successful even within EA at changing anything: superforecasters are generally far more relaxed about Xrisk than the median EA, but has this made any kind of difference to how EA spends its money? It seems very unlikely. And Marcus Abramovich here: I'm in the process of writing up my thoughts on forecasting in general and particularly EA's reverence for forecasting but I feel, similar to @Grayden that forecasting is a game that is nearly perfectly designed to distract EAs from useful things. It's a combination of winning, being right when others are wrong and seemingly useful, all wrapped into a fun game. I'd like to see tangible benefits to more broad funding of forecasting that seems to be done in t he millions and tens of millions of dollars. I would also be the type of person you would think would be a greater fan of forecasting. I'm the number one forecaster on Manifold and I've made tens of thousands of dollars on Polymarket. But I think we should start to think of forecasting as more of a game that EAs like to play, something like Magic the Gathering that is fun and has some relations to useful things but isn't really useful by itself. Eli Lifland has a long and hard-to-summarize comment here, response from Ozzie Gooen here, podcast between them on “Is Forecasting A Promising EA Cause Area?” here. I’m split on this. My previous hope was that the field would gradually grow, without any qualitative changes or discontinuities, until it became big enough that journalists and policy-makers were aware of it and took it seriously (compare eg the growth of the Internet as a scholarly resource). I think the strongest argument against this is Manifold’s relatively flat user numbers. Is there a new hope? I think if nothing else, forecasting might be useful as a testing ground: First, to create forecasting AIs (like FutureSearch) which can then get consulted on a variety of questions, eg by policy-makers. The biggest holdup has always been the need to gather 20 or 50 or however many hard-to-find superforecasters for whatever question you’re asking, and then trust their advice even though they’re fallible fleshbag humans. If you can use the 20 to 50 superforecasters to inspire an AI, and then test the AI and prove it’s good, people might be more interested. This is especially true if the AI can branch out beyond traditional forecasting questions. Once we have a few of these, we can start comparing the next generation of AIs to the previous generation, and skip the superforecasters.
Inline links: 1, 2, Manifold Markets says, https://manifold.markets/stats, Chumba Casino, Fliff, have to be handwritten in a very specific way, rejects them, more people, https://manifold.markets/Joshua/good-pivot-bad-pivot-which-opinions, leaving the site, Manifund, report on Superforecasting The Origins Of The COVID-19 Pandemic., https://substackcdn.com/image/fetch/$s_!F-e7!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F679c34d2-766f-41bd-ae75-b036bcdb06f9_1456x849.webp, https://substackcdn.com/image/fetch/$s_!JSEn!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F9c315554-fca5-4dc5-ac9a-d531b4ce7534_883x519.png, forecasting has a “rationale-shaped hole”, Nuno’s yearly forecasting roundup, Cultivate Labs, choosing to promote it to one of their main donation areas, here, superforecasters are generally far more relaxed about Xrisk, here, @Grayden, here, here, “Is Forecasting A Promising EA Cause Area?” here
Pizzagate1 mentions across 1 issues

Pizzagate is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between July 22, 2022 and July 22, 2022. The archive places it in contexts such as "Look at the parade the last few years - Pizzagate". It most often appears alongside 2020 election, 2022 book review contest, 2122.

Reference entry
Pizzagate
Mention count
1
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1
First seen
July 22, 2022
Last seen
July 22, 2022
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Your Book Review: The Society Of The Spectacle
July 22, 2022 · Original source
Of course people buy into things like Dead Internet Theory. Of course everyone’s flailing about, falling into rabbit holes that get more and more bizarre. Conspiracy theories are modern myths, blooming in the fertile soil of the spectacle. The mainstream news itself is little more than ceaseless conspiracy-mongering at this point. Look at the parade the last few years - Russiagate, Pizzagate, COVID, 2020 election, Jan. 6th… Whatever you might think about those highly controversial topics, many millions of people vehemently disagree with you. They live in an alternate universe. Many millions of other people agree with whatever your stance is - but for reasons so insane and illogical that they also inhabit a totally different reality.
Inline links: Dead Internet Theory, modern myths,
placebo1 mentions across 1 issues

placebo is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between November 14, 2023 and November 14, 2023. The archive places it in contexts such as "participants in the ketamine and placebo group". It most often appears alongside ketamine, ketamine, MADRS.

Reference entry
placebo
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1
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1
First seen
November 14, 2023
Last seen
November 14, 2023
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Does Anaesthesia Prove Ketamine Placebo?
November 14, 2023 · Original source
Ketamine is a dissociative drug - it produces weird drug effects like feelings of bodylessness and ego death. Recent research suggests it’s a powerful antidepressant. Usually we would try to run placebo-controlled trials. But it’s hard to run a placebo controlled trial of a dissociative. Either you feel bodylessness and ego death (in which case you know you’re getting the real drug) or you don’t (in which case you know you’re in the placebo group). Sometimes researchers try to use an “active placebo” like midazolam - a drug that makes you feel weird and floaty. But weird and floaty feels different from bodyless and ego-dead.
The authors of the recent study go further. They recruited depressed patients who were going into the hospital for routine surgery requiring anaesthesia. When they were anaesthesized, they gave them either ketamine or placebo. Then after they woke up, the researchers asked the patients how depressed they were. These patients had no way of telling whether they got ketamine or not (since they were unconscious at the time). Here are the results:
There was no tendency for the ketamine group to do better than the placebo group!
placebo effect1 mentions across 1 issues

placebo effect is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between March 10, 2021 and March 10, 2021. The archive places it in contexts such as "The placebo effect is almost equally simple". It most often appears alongside apocalypse cultism, Black Lives Matter, cynophobia.

Reference entry
placebo effect
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1
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1
First seen
March 10, 2021
Last seen
March 10, 2021
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Trapped Priors As A Basic Problem Of Rationality
March 10, 2021 · Original source
The placebo effect is almost equally simple. You're in pain, so your doctor gives you a “painkiller” (unbeknownst to you, it’s really a sugar pill). The raw experience is the nerve sending out just as many pain impulses as before. The context is that you've just taken a pill which a doctor assures you will make you feel better. Result: you feel less pain.
If you want to get out of a trapped prior, the most promising source of hope is the psychotherapeutic tradition of treating phobias and PTSD. These people tend to recommend very gradual exposure to the phobic stimulus, sometimes with special gimmicks to prevent you from getting scared or help you "process" the information (there's no consensus as to whether the eye movements in EMDR operate through some complicated neurological pathway, work as placebo, or just distract you from the fear). A lot of times the "processing" involves trying to remember the stimulus multimodally, in as much detail as possible - for example drawing your trauma, or acting it out.
placenta1 mentions across 1 issues

placenta is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between April 13, 2022 and April 13, 2022. The archive places it in contexts such as "placenta usually tries to keep fetal cortisol exposure low"; "The stress hormone cortisol can pass the placenta. Although the placenta usually tries to keep fetal cortisol exposure low". It most often appears alongside acetaminophen, ADHD, Arthur Jensen.

Reference entry
placenta
Mention count
1
Issue count
1
First seen
April 13, 2022
Last seen
April 13, 2022
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Obscure Pregnancy Interventions: Much More Than You Wanted To Know
April 13, 2022 · Original source
The stress hormone cortisol can pass the placenta. Although the placenta usually tries to keep fetal cortisol exposure low, high enough levels can overwhelm this mechanism. See this page on maternal-fetal stress transfer for details. The most interesting study is Gitau et al, which looks at maternal and fetal cortisol levels during various scary medical procedures, and finds that even procedures that don’t affect the fetus cause elevations in fetal cortisol, presumably because they caused elevations in maternal cortisol and some of it crossed over.
Inline links: maternal-fetal stress transfer, Gitau et al
Licorice contains the dangerous-sounding chemical glycyrrhizin. Glycyrrhizin turns off the placental enzymes that limit the amount of maternal stress hormones that pass to the developing fetus. A study shows that mothers who eat lots of licorice during pregnancy have children with 7 points lower IQ (on average) than mothers with more restraint in their licorice consumption. Others studies show increased maternal blood pressure, increased risk of preterm birth. There are relatively few studies here compared to some other interventions, but the studies seem strong, the mechanism seems plausible, and there are fewer possible confounders than usual.
Inline links: A study shows, maternal blood pressure, increased risk of preterm birth
Plan To End Homelessness1 mentions across 1 issues

Plan To End Homelessness is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between May 24, 2022 and May 24, 2022. The archive places it in contexts such as "He has what one could generously call a Plan To End Homelessness". It most often appears alongside #Abolitionist, #AntiNazi, #antiwar.

Mention count
1
Issue count
1
First seen
May 24, 2022
Last seen
May 24, 2022
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California Gubernatorial Candidates From Z to Z
May 24, 2022 · Original source
David Lozano is an attorney and former sheriff, running on a plan to end homelessness.
Inline links: David Lozano
Every candidate has a plan to end homelessness, but if you read carefully you’ll notice he’s just claiming to be the only one whose plan has that name. His plan:
Gavin has typical Democratic policies on most things. Like everyone else, he has a ridiculously-named Plan To End Homelessness, Project Roomkey, which will give homeless people hotel vouchers.
Inline links: Project Roomkey
Plantago ovata1 mentions across 1 issues

Plantago ovata is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between October 05, 2022 and October 05, 2022. The archive places it in contexts such as ""Plantago ovate." Presumably, they are referring to P. ovata (Plantaginaceae)"; ""Presumably, they are referring to P. ovata (Plantaginaceae)"". It most often appears alongside AIDP, Alkemist, Amazon.

Reference entry
Plantago ovata
Mention count
1
Issue count
1
First seen
October 05, 2022
Last seen
October 05, 2022
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How Trustworthy Are Supplements?
October 05, 2022 · Original source
Furthermore, in Table 1, the authors used the scientific name "Plantago ovate." Presumably, they are referring to P. ovata (Plantaginaceae), and their spellchecker automatically tried to correct “ovata” to “ovate,” an error that the authors, and, presumably, peer reviewers, should have detected. Even though this might seem trivial, and, in some cases, it might be, it implies that either the authors and/or the peer reviewers are not adequately familiar with the scientific botanical nomenclature, and presumably, other aspects of botany and medicinal plants that could have informed a more cohesive and reliable publication.
Platelet-Derived growth factor (PDGF-β)1 mentions across 1 issues

Platelet-Derived growth factor (PDGF-β) is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between July 11, 2025 and July 11, 2025. The archive places it in contexts such as "PDAPP (Platelet-Derived growth factor (PDGF-β) Amyloid Precursor Protein)". It most often appears alongside aducanumab, Alzheimer’s, Alzheimer’s Disease.

Mention count
1
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1
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July 11, 2025
Last seen
July 11, 2025
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Your Review: Of Mice, Mechanisms, and Dementia
July 11, 2025 · Original source
No direct inline source block was recovered for this mention.
Platonic contract1 mentions across 1 issues

Platonic contract is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between December 17, 2024 and December 17, 2024. The archive places it in contexts such as "everyone would agree to in an ideal Platonic contract". It most often appears alongside 2016 US Presidential election, ACX Grant, AI.

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Platonic contract
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1
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1
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December 17, 2024
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December 17, 2024
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Links For December 2024
December 17, 2024 · Original source
I also got in a series of Twitter discussions here where I claimed that probably all charity is supererogatory. Some of the discussions were a little successful in arguing me down from this, and I’m currently not sure whether it’s all supererogatory or whether it’s obligatory up to some small amount (possibly the amount that everyone would agree to in an ideal Platonic contract, or whatever the prevailing moral norm - eg 1% or 10% - but the fact that we can’t actually agree on this makes me suspicious that there’s not really a prevailing moral norm and pushes me more towards supererogatory).
Inline links: a series of Twitter discussions here, ideal Platonic contract, 1%, 10%
Platonic Realm1 mentions across 1 issues

Platonic Realm is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between September 17, 2021 and September 17, 2021. The archive places it in contexts such as "who could journey to the Platonic Realm and bring back new insights". It most often appears alongside 1/6 insurrection, Abdel al-Sisi, Abu Ghraib.

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Platonic Realm
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1
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1
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September 17, 2021
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September 17, 2021
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Book Review: The Revolt Of The Public
September 17, 2021 · Original source
Some principles of this system: government management of the economy, under the wise infallible leadership of Alan-Greenspan-style boffins who could prevent recessions and resist "animal spirits". Government sponsorship of science, under the wise infallible leadership of Einstein-style geniuses who could journey to the Platonic Realm and bring back new insights for the rest of us to gawk at. Government management of society, in the form of Wars on Poverty and Wars on Drugs and exciting new centralized forms of public education that would make every child an above-average student. Homelessness getting cleared away by a wave of the city planner's pen, replaced by scientifically-designed heavily optimized efficient public housing like Cabrini-Green.
Inline links: Cabrini-Green
Platonists1 mentions across 1 issues

Platonists is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between December 05, 2024 and December 05, 2024. The archive places it in contexts such as "But most of the critics aren’t Platonists". It most often appears alongside @dieworkwear, AI Art Turing Test, Bauhaus.

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Platonists
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1
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1
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December 05, 2024
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December 05, 2024
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Friendly And Hostile Analogies For Taste
December 05, 2024 · Original source
But most of the critics aren’t Platonists - they don’t believe that aesthetics are an objective good determined by God. So what does it mean to say that someone else is wrong?
Plato’s Cave1 mentions across 1 issues

Plato’s Cave is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between July 22, 2022 and July 22, 2022. The archive places it in contexts such as "There is no exit to Plato’s Cave". It most often appears alongside 2020 election, 2022 book review contest, 2122.

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Plato’s Cave
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1
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1
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July 22, 2022
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July 22, 2022
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Your Book Review: The Society Of The Spectacle
July 22, 2022 · Original source
There is much that is new and unnerving about the spectacle, but in some ways it is merely a return to an earlier paradigm. Delusion is the natural state of man. There is no exit to Plato’s Cave. It was only conceit that we ever thought we were more enlightened than our forebears.
Platt's Law1 mentions across 1 issues

Platt's Law is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between February 23, 2022 and February 23, 2022. The archive places it in contexts such as "for the same Platt’s-Law-related reasons". It most often appears alongside AGI, AI Impacts, AIXI.

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Platt's Law
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1
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1
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February 23, 2022
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February 23, 2022
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Biological Anchors: A Trick That Might Or Might Not Work
February 23, 2022 · Original source
Platt’s Law in blue, regression line in orange. He writes: I agree this trendline doesn't look great for Platt's law, and backs up your observation by predicting that Bio Anchors should be more than 30 years out. However, OLS is notoriously sensitive to outliers. If instead of using some more robust regression algorithm, we instead super arbitrarily eliminated all predictions after 2100, then we get this, which doesn't look absolutely horrible for the law. Note that the median forecast is 25 years out. I’m split on what to think here. If we consider a weaker version of Platt’s Law, “the average date at which people forecast AGI moves forward at about one year per year”, this seems truish in the big picture where we compare 1960 to today, but not obviously true after 1980. If we consider a different weaker version, “on average estimates tend to be 30 years away”, that’s true-ish under Barnett’s revised model, but not inherently damning since Barnett’s assuming there will be some such number, it turns out to be 25, and Ajeya gave the somewhat different number of 32. Is that a big enough difference to exonerate her of “using” Platt’s Law? Is that even the right way to be thinking about this question? Response 3: Real OpenPhil The hypothetical OpenPhil in Eliezer’s mind having been utterly vanquished, the real-world OpenPhil is forced to step in. OpenPhil CEO Holden Karnofsky responds to Eliezer here. There’s a lot of back and forth about whether the report includes enough caveats (answer: it sure does include a lot of caveats!) but I was most interested in the attacks on Eliezer’s two main points. First, the point that biological anchors are fatally flawed from the start and measuring FLOP/S is no better than measuring power consumption in watts. Holden: If the world were such that: We had some reasonable framework for "power usage" that didn't include gratuitously wasted power, and measured the "power used meaningfully to do computations" in some important sense;
Inline links: writes, https://substackcdn.com/image/fetch/$s_!dw02!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F797aef17-dc24-4845-9e00-2c3fd7f7dc32_403x268.png, here
Play pro-level Go using 8-16 times as much computing power as AlphaGo, but only 2006 levels of technology. For reference, recall that in 2006, Hinton and Salakhutdinov were just starting to publish that, by training multiple layers of Restricted Boltzmann machines and then unrolling them into a "deep" neural network, you could get an initialization for the network weights that would avoid the problem of vanishing and exploding gradients and activations. At least so long as you didn't try to stack too many layers, like a dozen layers or something ridiculous like that. This being the point that kicked off the entire deep-learning revolution. Your model apparently suggests that we have gotten around 50 times more efficient at turning computation into intelligence since that time; so, we should be able to replicate any modern feat of deep learning performed in 2021, using techniques from before deep learning and around fifty times as much computing power. OpenPhil: No, that's totally not what our viewpoint says when you backfit it to past reality. Our model does a great job of retrodicting past reality. Eliezer: How so? OpenPhil: <Eliezer cannot predict what they will say here.> I think the argument here is that OpenPhil is accounting for normal scientific progress in algorithms, but not for paradigm shifts. Directional Error These are the two arguments Eliezer makes against OpenPhil that I find most persuasive. First, that you shouldn’t be using biological anchors at all. Second, that unpredictable paradigm shifts are more realistic than gradual algorithmic progress. These mostly add uncertainty to OpenPhil’s model, but Eliezer ends his essay making a stronger argument: he thinks OpenPhil is directionally wrong, and AI will come earlier than they think. Mostly this is the paradigm argument again. Five years from now, there could be a paradigm shift that makes AI much easier to build. It’s happened before; from GOFAI’s pre-programmed logical rules to Deep Blue’s tree searches to the sorts of Big Data methods that won the Netflix Prize to modern deep learning. Instead of just extrapolating deep learning scaling thirty years out, OpenPhil should be worried about the next big idea. Hypothetical OpenPhil retorts that this is a double-edged sword. Maybe the deep learning paradigm can’t produce AGI, and we’ll have to wait decades or centuries for someone to have the right insight. Or maybe the new paradigm you need for AGI will take more compute than deep learning, in the same way deep learning takes more compute than whatever Moravec was imagining. This is a pretty strong response, since it would have been true for every previous forecaster: remember, Moravec erred in thinking AI would come too soon, not too late. So although Eliezer is taking the cheap shot of saying OpenPhil’s estimate will be wrong just as everyone else’s was wrong before, he’s also giving himself the much harder case of arguing it might be wrong in the opposite direction as all its predecessors. Eliezer takes this objection seriously, but feels like on balance probably new paradigms will speed up AI rather than slow it down. Here he grudgingly and with suitable embarrassment does try to make an object-level semi-biological-anchors-related argument: Moravec was wrong because he ignored the training phase. And the proper anchor for the training phase is somewhere between evolution and a human childhood, where evolution represents “blind chance eventually finding good things” and human childhood represents “an intelligent cognitive engine trying to squeeze as much data out of experience as possible”. And part of what he expects paradigm shifts to do is to move from more evolutionary processes to more childhood-like processes, and that’s a net gain in efficiency. So he still thinks OpenPhil’s methods are more likely to overestimate the amount of time until AGI rather than underestimate it. What Moore’s Law Giveth, Platt’s Law Taketh Away Eliezer’s other argument is kind of a low blow: he refers to Platt’s Law Of AI Forecasting: “any AI forecast will put strong AI thirty years out from when the forecast is made.” This isn’t exact. Hans Moravec, writing in 1988, said 2010 - so 22 years. Ray Kurzweil, writing in 2001, said 2023 - another 22 years. Vernor Vinge, in a 1993 speech, said 2023, and that was exactly 30 years, but Vinge knew about Platt’s Law and might have been joking. The point is: OpenPhil wrote a report in 2020 that predicted strong AI in 2052, isn’t that kind of suspicious? I’d previously mentioned it as a plus that Ajeya got around the same year everyone else got. The forecasters on Metaculus. The experts surveyed in Grace et al. Lots of other smart experts with clever models. But what if all of these experts and models and analyses are just fudging the numbers for the same Platt’s-Law-related reasons? Hypothetical OpenPhil is BTFO: OpenPhil: That part about Charles Platt's generalization is interesting, but just because we unwittingly chose literally exactly the median that Platt predicted people would always choose in consistent error, that doesn't justify dismissing our work, right? We could have used a completely valid method of estimation which would have pointed to 2050 no matter which year it was tried in, and, by sheer coincidence, have first written that up in 2020. In fact, we try to show in the report that the same methodology, evaluated in earlier years, would also have pointed to around 2050 - Eliezer: Look, people keep trying this. It's never worked. It's never going to work. 2 years before the end of the world, there'll be another published biologically inspired estimate showing that AGI is 30 years away and it will be exactly as informative then as it is now. I'd love to know the timelines too, but you're not going to get the answer you want until right before the end of the world, and maybe not even then unless you're paying very close attention. Timing this stuff is just plain hard. Part III: Responses And Commentary Response 1: Less Wrong Comments Less Wrong is a site founded by Eliezer Yudkowsky for Eliezer Yudkowsky fans who wanted to discuss Eliezer Yudkowsky’s ideas. So, for whatever it’s worth - the comments on his essay were pretty negative. Carl Shulman, an independent researcher with links to both OpenPhil and MIRI (Eliezer’s org), writes the top-voted comment. He works from a model where there is hardware progress, software progress downstream of hardware progress, and independent (ie unrelated to algorithms) software progress, and where the first two make up most progress on the margin. Researchers generally develop new paradigms once they have enough compute available to tinker with them. Progress in AI has largely been a function of increasing compute, human software research efforts, and serial time/steps. Throwing more compute at researchers has improved performance both directly and indirectly (e.g. by enabling more experiments, refining evaluation functions in chess, training neural networks, or making algorithms that work best with large compute more attractive). Historically compute has grown by many orders of magnitude, while human labor applied to AI and supporting software by only a few. And on plausible decompositions of progress (allowing for adjustment of software to current hardware and vice versa), hardware growth accounts for more of the progress over time than human labor input growth. So if you're going to use an AI production function for tech forecasting based on inputs (which do relatively OK by the standards tech forecasting), it's best to use all of compute, labor, and time, but it makes sense for compute to have pride of place and take in more modeling effort and attention, since it's the biggest source of change (particularly when including software gains downstream of hardware technology and expenditures). […] A perfectly correlated time series of compute and labor would not let us say which had the larger marginal contribution, but we have resources to get at that, which I was referring to with 'plausible decompositions.' This includes experiments with old and new software and hardware, like the chess ones Paul recently commissioned, and studies by AI Impacts, OpenAI, and Neil Thompson. There are AI scaling experiments, and observations of the results of shocks like the end of Dennard scaling, the availability of GPGPU computing, and Besiroglu's data on the relative predictive power of computer and labor in individual papers and subfields. In different ways those tend to put hardware as driving more log improvement than software (with both contributing), particularly if we consider software innovations downstream of hardware changes. Vanessa Kosoy makes the obvious objection, which echoes a comment of Eliezer’s in the dialogue above: I'm confused how can this pass some obvious tests. For example, do you claim that alpha-beta pruning can match AlphaGo given some not-crazy advantage in compute? Do you claim that SVMs can do SOTA image classification with not-crazy advantage in compute (or with any amount of compute with the same training data)? Can Eliza-style chatbots compete with GPT3 however we scale them up? Mark Xu answers: My model is something like: For any given algorithm, e.g. SVMs, AlphaGo, alpha-beta pruning, convnets, etc., there is an "effective compute regime" where dumping more compute makes them better. If you go above this regime, you get steep diminishing marginal returns.
Inline links: normal scientific progress in algorithms, but not for paradigm shifts, Platt’s Law Of AI Forecasting, the comments, Paul recently commissioned, AI Impacts, OpenAI, Neil Thompson, Besiroglu's, Vanessa Kosoy, Mark Xu
Platt’s Law1 mentions across 1 issues

Platt’s Law is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between February 23, 2022 and February 23, 2022. The archive places it in contexts such as "the line corresponding to Platt’s Law (everyone always predicts AI in thirty years)"; "Platt’s Law looks pretty good". It most often appears alongside AGI, AI Impacts, AIXI.

Reference entry
Platt’s Law
Mention count
1
Issue count
1
First seen
February 23, 2022
Last seen
February 23, 2022
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Issue trail
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Source context
Biological Anchors: A Trick That Might Or Might Not Work
February 23, 2022 · Original source
Play pro-level Go using 8-16 times as much computing power as AlphaGo, but only 2006 levels of technology. For reference, recall that in 2006, Hinton and Salakhutdinov were just starting to publish that, by training multiple layers of Restricted Boltzmann machines and then unrolling them into a "deep" neural network, you could get an initialization for the network weights that would avoid the problem of vanishing and exploding gradients and activations. At least so long as you didn't try to stack too many layers, like a dozen layers or something ridiculous like that. This being the point that kicked off the entire deep-learning revolution. Your model apparently suggests that we have gotten around 50 times more efficient at turning computation into intelligence since that time; so, we should be able to replicate any modern feat of deep learning performed in 2021, using techniques from before deep learning and around fifty times as much computing power. OpenPhil: No, that's totally not what our viewpoint says when you backfit it to past reality. Our model does a great job of retrodicting past reality. Eliezer: How so? OpenPhil: <Eliezer cannot predict what they will say here.> I think the argument here is that OpenPhil is accounting for normal scientific progress in algorithms, but not for paradigm shifts. Directional Error These are the two arguments Eliezer makes against OpenPhil that I find most persuasive. First, that you shouldn’t be using biological anchors at all. Second, that unpredictable paradigm shifts are more realistic than gradual algorithmic progress. These mostly add uncertainty to OpenPhil’s model, but Eliezer ends his essay making a stronger argument: he thinks OpenPhil is directionally wrong, and AI will come earlier than they think. Mostly this is the paradigm argument again. Five years from now, there could be a paradigm shift that makes AI much easier to build. It’s happened before; from GOFAI’s pre-programmed logical rules to Deep Blue’s tree searches to the sorts of Big Data methods that won the Netflix Prize to modern deep learning. Instead of just extrapolating deep learning scaling thirty years out, OpenPhil should be worried about the next big idea. Hypothetical OpenPhil retorts that this is a double-edged sword. Maybe the deep learning paradigm can’t produce AGI, and we’ll have to wait decades or centuries for someone to have the right insight. Or maybe the new paradigm you need for AGI will take more compute than deep learning, in the same way deep learning takes more compute than whatever Moravec was imagining. This is a pretty strong response, since it would have been true for every previous forecaster: remember, Moravec erred in thinking AI would come too soon, not too late. So although Eliezer is taking the cheap shot of saying OpenPhil’s estimate will be wrong just as everyone else’s was wrong before, he’s also giving himself the much harder case of arguing it might be wrong in the opposite direction as all its predecessors. Eliezer takes this objection seriously, but feels like on balance probably new paradigms will speed up AI rather than slow it down. Here he grudgingly and with suitable embarrassment does try to make an object-level semi-biological-anchors-related argument: Moravec was wrong because he ignored the training phase. And the proper anchor for the training phase is somewhere between evolution and a human childhood, where evolution represents “blind chance eventually finding good things” and human childhood represents “an intelligent cognitive engine trying to squeeze as much data out of experience as possible”. And part of what he expects paradigm shifts to do is to move from more evolutionary processes to more childhood-like processes, and that’s a net gain in efficiency. So he still thinks OpenPhil’s methods are more likely to overestimate the amount of time until AGI rather than underestimate it. What Moore’s Law Giveth, Platt’s Law Taketh Away Eliezer’s other argument is kind of a low blow: he refers to Platt’s Law Of AI Forecasting: “any AI forecast will put strong AI thirty years out from when the forecast is made.” This isn’t exact. Hans Moravec, writing in 1988, said 2010 - so 22 years. Ray Kurzweil, writing in 2001, said 2023 - another 22 years. Vernor Vinge, in a 1993 speech, said 2023, and that was exactly 30 years, but Vinge knew about Platt’s Law and might have been joking. The point is: OpenPhil wrote a report in 2020 that predicted strong AI in 2052, isn’t that kind of suspicious? I’d previously mentioned it as a plus that Ajeya got around the same year everyone else got. The forecasters on Metaculus. The experts surveyed in Grace et al. Lots of other smart experts with clever models. But what if all of these experts and models and analyses are just fudging the numbers for the same Platt’s-Law-related reasons? Hypothetical OpenPhil is BTFO: OpenPhil: That part about Charles Platt's generalization is interesting, but just because we unwittingly chose literally exactly the median that Platt predicted people would always choose in consistent error, that doesn't justify dismissing our work, right? We could have used a completely valid method of estimation which would have pointed to 2050 no matter which year it was tried in, and, by sheer coincidence, have first written that up in 2020. In fact, we try to show in the report that the same methodology, evaluated in earlier years, would also have pointed to around 2050 - Eliezer: Look, people keep trying this. It's never worked. It's never going to work. 2 years before the end of the world, there'll be another published biologically inspired estimate showing that AGI is 30 years away and it will be exactly as informative then as it is now. I'd love to know the timelines too, but you're not going to get the answer you want until right before the end of the world, and maybe not even then unless you're paying very close attention. Timing this stuff is just plain hard. Part III: Responses And Commentary Response 1: Less Wrong Comments Less Wrong is a site founded by Eliezer Yudkowsky for Eliezer Yudkowsky fans who wanted to discuss Eliezer Yudkowsky’s ideas. So, for whatever it’s worth - the comments on his essay were pretty negative. Carl Shulman, an independent researcher with links to both OpenPhil and MIRI (Eliezer’s org), writes the top-voted comment. He works from a model where there is hardware progress, software progress downstream of hardware progress, and independent (ie unrelated to algorithms) software progress, and where the first two make up most progress on the margin. Researchers generally develop new paradigms once they have enough compute available to tinker with them. Progress in AI has largely been a function of increasing compute, human software research efforts, and serial time/steps. Throwing more compute at researchers has improved performance both directly and indirectly (e.g. by enabling more experiments, refining evaluation functions in chess, training neural networks, or making algorithms that work best with large compute more attractive). Historically compute has grown by many orders of magnitude, while human labor applied to AI and supporting software by only a few. And on plausible decompositions of progress (allowing for adjustment of software to current hardware and vice versa), hardware growth accounts for more of the progress over time than human labor input growth. So if you're going to use an AI production function for tech forecasting based on inputs (which do relatively OK by the standards tech forecasting), it's best to use all of compute, labor, and time, but it makes sense for compute to have pride of place and take in more modeling effort and attention, since it's the biggest source of change (particularly when including software gains downstream of hardware technology and expenditures). […] A perfectly correlated time series of compute and labor would not let us say which had the larger marginal contribution, but we have resources to get at that, which I was referring to with 'plausible decompositions.' This includes experiments with old and new software and hardware, like the chess ones Paul recently commissioned, and studies by AI Impacts, OpenAI, and Neil Thompson. There are AI scaling experiments, and observations of the results of shocks like the end of Dennard scaling, the availability of GPGPU computing, and Besiroglu's data on the relative predictive power of computer and labor in individual papers and subfields. In different ways those tend to put hardware as driving more log improvement than software (with both contributing), particularly if we consider software innovations downstream of hardware changes. Vanessa Kosoy makes the obvious objection, which echoes a comment of Eliezer’s in the dialogue above: I'm confused how can this pass some obvious tests. For example, do you claim that alpha-beta pruning can match AlphaGo given some not-crazy advantage in compute? Do you claim that SVMs can do SOTA image classification with not-crazy advantage in compute (or with any amount of compute with the same training data)? Can Eliza-style chatbots compete with GPT3 however we scale them up? Mark Xu answers: My model is something like: For any given algorithm, e.g. SVMs, AlphaGo, alpha-beta pruning, convnets, etc., there is an "effective compute regime" where dumping more compute makes them better. If you go above this regime, you get steep diminishing marginal returns.
Inline links: normal scientific progress in algorithms, but not for paradigm shifts, Platt’s Law Of AI Forecasting, the comments, Paul recently commissioned, AI Impacts, OpenAI, Neil Thompson, Besiroglu's, Vanessa Kosoy, Mark Xu
I wanted to compare Fritz (which won WCCC in 1995) to a modern engine to understand the effects of hardware and software performance. I think the time controls for that tournament are similar to SF STC I think. I wanted to compare to SF8 rather than one of the NNUE engines to isolate out the effect of compute at development time and just look at test-time compute. So having modern algorithms would have let you win WCCC while spending about 50x less on compute than the winner. Having modern computer hardware would have let you win WCCC spending way more than 1000x less on compute than the winner. Measured this way software progress seems to be several times less important than hardware progress despite much faster scale-up of investment in software. But instead of asking "how well does hardware/software progress help you get to 1995 performance?" you could ask "how well does hardware/software progress get you to 2015 performance?" and on that metric it looks like software progress is way more important because you basically just can't scale old algorithms up to modern performance. The relevant measure varies depending on what you are asking. But from the perspective of takeoff speeds, it seems to me like one very salient takeaway is: if one chess project had literally come back in time with 20 years of chess progress, it would have allowed them to spend 50x less on compute than the leader. Response 2: AI Impacts + Matthew Barnett AI Impacts gathered and analyzed a dataset of who predicted AI when; Matthew Barnett helpfully drew in the line corresponding to Platt’s Law (everyone always predicts AI in thirty years). Just eyeballing it, Platt’s Law looks pretty good. But Holden Karnofsky (see below) objects that our eyeballs are covertly removing outliers. Barnett agrees this is worth checking for and runs a formal OLS regression. Platt’s Law in blue, regression line in orange. He writes: I agree this trendline doesn't look great for Platt's law, and backs up your observation by predicting that Bio Anchors should be more than 30 years out. However, OLS is notoriously sensitive to outliers. If instead of using some more robust regression algorithm, we instead super arbitrarily eliminated all predictions after 2100, then we get this, which doesn't look absolutely horrible for the law. Note that the median forecast is 25 years out. I’m split on what to think here. If we consider a weaker version of Platt’s Law, “the average date at which people forecast AGI moves forward at about one year per year”, this seems truish in the big picture where we compare 1960 to today, but not obviously true after 1980. If we consider a different weaker version, “on average estimates tend to be 30 years away”, that’s true-ish under Barnett’s revised model, but not inherently damning since Barnett’s assuming there will be some such number, it turns out to be 25, and Ajeya gave the somewhat different number of 32. Is that a big enough difference to exonerate her of “using” Platt’s Law? Is that even the right way to be thinking about this question? Response 3: Real OpenPhil The hypothetical OpenPhil in Eliezer’s mind having been utterly vanquished, the real-world OpenPhil is forced to step in. OpenPhil CEO Holden Karnofsky responds to Eliezer here. There’s a lot of back and forth about whether the report includes enough caveats (answer: it sure does include a lot of caveats!) but I was most interested in the attacks on Eliezer’s two main points. First, the point that biological anchors are fatally flawed from the start and measuring FLOP/S is no better than measuring power consumption in watts. Holden: If the world were such that: We had some reasonable framework for "power usage" that didn't include gratuitously wasted power, and measured the "power used meaningfully to do computations" in some important sense;
Inline links: AI Impacts, Matthew Barnett, https://substackcdn.com/image/fetch/$s_!17-W!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2Fa751f624-0392-4610-8a93-7bb94a60d1b3_1182x778.png, https://substackcdn.com/image/fetch/$s_!54Vh!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F1c354075-ecaa-4807-a1a5-07931736f093_403x268.png, writes, https://substackcdn.com/image/fetch/$s_!dw02!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F797aef17-dc24-4845-9e00-2c3fd7f7dc32_403x268.png, here
Just eyeballing it, Platt’s Law looks pretty good. But Holden Karnofsky (see below) objects that our eyeballs are covertly removing outliers. Barnett agrees this is worth checking for and runs a formal OLS regression. Platt’s Law in blue, regression line in orange. He writes: I agree this trendline doesn't look great for Platt's law, and backs up your observation by predicting that Bio Anchors should be more than 30 years out. However, OLS is notoriously sensitive to outliers. If instead of using some more robust regression algorithm, we instead super arbitrarily eliminated all predictions after 2100, then we get this, which doesn't look absolutely horrible for the law. Note that the median forecast is 25 years out. I’m split on what to think here. If we consider a weaker version of Platt’s Law, “the average date at which people forecast AGI moves forward at about one year per year”, this seems truish in the big picture where we compare 1960 to today, but not obviously true after 1980. If we consider a different weaker version, “on average estimates tend to be 30 years away”, that’s true-ish under Barnett’s revised model, but not inherently damning since Barnett’s assuming there will be some such number, it turns out to be 25, and Ajeya gave the somewhat different number of 32. Is that a big enough difference to exonerate her of “using” Platt’s Law? Is that even the right way to be thinking about this question? Response 3: Real OpenPhil The hypothetical OpenPhil in Eliezer’s mind having been utterly vanquished, the real-world OpenPhil is forced to step in. OpenPhil CEO Holden Karnofsky responds to Eliezer here. There’s a lot of back and forth about whether the report includes enough caveats (answer: it sure does include a lot of caveats!) but I was most interested in the attacks on Eliezer’s two main points. First, the point that biological anchors are fatally flawed from the start and measuring FLOP/S is no better than measuring power consumption in watts. Holden: If the world were such that: We had some reasonable framework for "power usage" that didn't include gratuitously wasted power, and measured the "power used meaningfully to do computations" in some important sense;
Inline links: https://substackcdn.com/image/fetch/$s_!54Vh!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F1c354075-ecaa-4807-a1a5-07931736f093_403x268.png, writes, https://substackcdn.com/image/fetch/$s_!dw02!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F797aef17-dc24-4845-9e00-2c3fd7f7dc32_403x268.png, here
Platt’s Law Of AI Forecasting1 mentions across 1 issues

Platt’s Law Of AI Forecasting is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between February 23, 2022 and February 23, 2022. The archive places it in contexts such as "he refers to Platt’s Law Of AI Forecasting: “any AI forecast will put strong AI thirty years out from when the forecast is made.”". It most often appears alongside AGI, AI Impacts, AIXI.

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1
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1
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February 23, 2022
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February 23, 2022
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Biological Anchors: A Trick That Might Or Might Not Work
February 23, 2022 · Original source
Play pro-level Go using 8-16 times as much computing power as AlphaGo, but only 2006 levels of technology. For reference, recall that in 2006, Hinton and Salakhutdinov were just starting to publish that, by training multiple layers of Restricted Boltzmann machines and then unrolling them into a "deep" neural network, you could get an initialization for the network weights that would avoid the problem of vanishing and exploding gradients and activations. At least so long as you didn't try to stack too many layers, like a dozen layers or something ridiculous like that. This being the point that kicked off the entire deep-learning revolution. Your model apparently suggests that we have gotten around 50 times more efficient at turning computation into intelligence since that time; so, we should be able to replicate any modern feat of deep learning performed in 2021, using techniques from before deep learning and around fifty times as much computing power. OpenPhil: No, that's totally not what our viewpoint says when you backfit it to past reality. Our model does a great job of retrodicting past reality. Eliezer: How so? OpenPhil: <Eliezer cannot predict what they will say here.> I think the argument here is that OpenPhil is accounting for normal scientific progress in algorithms, but not for paradigm shifts. Directional Error These are the two arguments Eliezer makes against OpenPhil that I find most persuasive. First, that you shouldn’t be using biological anchors at all. Second, that unpredictable paradigm shifts are more realistic than gradual algorithmic progress. These mostly add uncertainty to OpenPhil’s model, but Eliezer ends his essay making a stronger argument: he thinks OpenPhil is directionally wrong, and AI will come earlier than they think. Mostly this is the paradigm argument again. Five years from now, there could be a paradigm shift that makes AI much easier to build. It’s happened before; from GOFAI’s pre-programmed logical rules to Deep Blue’s tree searches to the sorts of Big Data methods that won the Netflix Prize to modern deep learning. Instead of just extrapolating deep learning scaling thirty years out, OpenPhil should be worried about the next big idea. Hypothetical OpenPhil retorts that this is a double-edged sword. Maybe the deep learning paradigm can’t produce AGI, and we’ll have to wait decades or centuries for someone to have the right insight. Or maybe the new paradigm you need for AGI will take more compute than deep learning, in the same way deep learning takes more compute than whatever Moravec was imagining. This is a pretty strong response, since it would have been true for every previous forecaster: remember, Moravec erred in thinking AI would come too soon, not too late. So although Eliezer is taking the cheap shot of saying OpenPhil’s estimate will be wrong just as everyone else’s was wrong before, he’s also giving himself the much harder case of arguing it might be wrong in the opposite direction as all its predecessors. Eliezer takes this objection seriously, but feels like on balance probably new paradigms will speed up AI rather than slow it down. Here he grudgingly and with suitable embarrassment does try to make an object-level semi-biological-anchors-related argument: Moravec was wrong because he ignored the training phase. And the proper anchor for the training phase is somewhere between evolution and a human childhood, where evolution represents “blind chance eventually finding good things” and human childhood represents “an intelligent cognitive engine trying to squeeze as much data out of experience as possible”. And part of what he expects paradigm shifts to do is to move from more evolutionary processes to more childhood-like processes, and that’s a net gain in efficiency. So he still thinks OpenPhil’s methods are more likely to overestimate the amount of time until AGI rather than underestimate it. What Moore’s Law Giveth, Platt’s Law Taketh Away Eliezer’s other argument is kind of a low blow: he refers to Platt’s Law Of AI Forecasting: “any AI forecast will put strong AI thirty years out from when the forecast is made.” This isn’t exact. Hans Moravec, writing in 1988, said 2010 - so 22 years. Ray Kurzweil, writing in 2001, said 2023 - another 22 years. Vernor Vinge, in a 1993 speech, said 2023, and that was exactly 30 years, but Vinge knew about Platt’s Law and might have been joking. The point is: OpenPhil wrote a report in 2020 that predicted strong AI in 2052, isn’t that kind of suspicious? I’d previously mentioned it as a plus that Ajeya got around the same year everyone else got. The forecasters on Metaculus. The experts surveyed in Grace et al. Lots of other smart experts with clever models. But what if all of these experts and models and analyses are just fudging the numbers for the same Platt’s-Law-related reasons? Hypothetical OpenPhil is BTFO: OpenPhil: That part about Charles Platt's generalization is interesting, but just because we unwittingly chose literally exactly the median that Platt predicted people would always choose in consistent error, that doesn't justify dismissing our work, right? We could have used a completely valid method of estimation which would have pointed to 2050 no matter which year it was tried in, and, by sheer coincidence, have first written that up in 2020. In fact, we try to show in the report that the same methodology, evaluated in earlier years, would also have pointed to around 2050 - Eliezer: Look, people keep trying this. It's never worked. It's never going to work. 2 years before the end of the world, there'll be another published biologically inspired estimate showing that AGI is 30 years away and it will be exactly as informative then as it is now. I'd love to know the timelines too, but you're not going to get the answer you want until right before the end of the world, and maybe not even then unless you're paying very close attention. Timing this stuff is just plain hard. Part III: Responses And Commentary Response 1: Less Wrong Comments Less Wrong is a site founded by Eliezer Yudkowsky for Eliezer Yudkowsky fans who wanted to discuss Eliezer Yudkowsky’s ideas. So, for whatever it’s worth - the comments on his essay were pretty negative. Carl Shulman, an independent researcher with links to both OpenPhil and MIRI (Eliezer’s org), writes the top-voted comment. He works from a model where there is hardware progress, software progress downstream of hardware progress, and independent (ie unrelated to algorithms) software progress, and where the first two make up most progress on the margin. Researchers generally develop new paradigms once they have enough compute available to tinker with them. Progress in AI has largely been a function of increasing compute, human software research efforts, and serial time/steps. Throwing more compute at researchers has improved performance both directly and indirectly (e.g. by enabling more experiments, refining evaluation functions in chess, training neural networks, or making algorithms that work best with large compute more attractive). Historically compute has grown by many orders of magnitude, while human labor applied to AI and supporting software by only a few. And on plausible decompositions of progress (allowing for adjustment of software to current hardware and vice versa), hardware growth accounts for more of the progress over time than human labor input growth. So if you're going to use an AI production function for tech forecasting based on inputs (which do relatively OK by the standards tech forecasting), it's best to use all of compute, labor, and time, but it makes sense for compute to have pride of place and take in more modeling effort and attention, since it's the biggest source of change (particularly when including software gains downstream of hardware technology and expenditures). […] A perfectly correlated time series of compute and labor would not let us say which had the larger marginal contribution, but we have resources to get at that, which I was referring to with 'plausible decompositions.' This includes experiments with old and new software and hardware, like the chess ones Paul recently commissioned, and studies by AI Impacts, OpenAI, and Neil Thompson. There are AI scaling experiments, and observations of the results of shocks like the end of Dennard scaling, the availability of GPGPU computing, and Besiroglu's data on the relative predictive power of computer and labor in individual papers and subfields. In different ways those tend to put hardware as driving more log improvement than software (with both contributing), particularly if we consider software innovations downstream of hardware changes. Vanessa Kosoy makes the obvious objection, which echoes a comment of Eliezer’s in the dialogue above: I'm confused how can this pass some obvious tests. For example, do you claim that alpha-beta pruning can match AlphaGo given some not-crazy advantage in compute? Do you claim that SVMs can do SOTA image classification with not-crazy advantage in compute (or with any amount of compute with the same training data)? Can Eliza-style chatbots compete with GPT3 however we scale them up? Mark Xu answers: My model is something like: For any given algorithm, e.g. SVMs, AlphaGo, alpha-beta pruning, convnets, etc., there is an "effective compute regime" where dumping more compute makes them better. If you go above this regime, you get steep diminishing marginal returns.
Inline links: normal scientific progress in algorithms, but not for paradigm shifts, Platt’s Law Of AI Forecasting, the comments, Paul recently commissioned, AI Impacts, OpenAI, Neil Thompson, Besiroglu's, Vanessa Kosoy, Mark Xu
platypus venom1 mentions across 1 issues

platypus venom is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between May 15, 2024 and May 15, 2024. The archive places it in contexts such as "The most exotic cause of this syndrome has to be platypus venom". It most often appears alongside @the_megabase, A Pan-Species Welfare State, ACX Grantees.

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platypus venom
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1
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1
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May 15, 2024
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May 15, 2024
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Profile: The Far Out Initiative
May 15, 2024 · Original source
Some people feel more pain than others. The “more pain” category includes some big demographic groups like redheads, who seem to feel some types of pain more intensely and may need up to 20% more anaesthetic, though their exact processing differences are complicated. But there are also various lesser-known genetic conditions that can make bizarre things - water, light touch, mild temperature changes - excruciatingly painful. The most exotic cause of this syndrome has to be platypus venom, which is both painful in and of itself and also seems to increase the body’s overall capacity to feel pain; for years after a platypus scratch, every tiny scrape will hurt worse than usual.
Inline links: seem to feel some types of pain more intensely, may need up to 20% more anaesthetic, exact processing differences are complicated, platypus venom
playing to extinction1 mentions across 1 issues

playing to extinction is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between May 14, 2021 and May 14, 2021. The archive places it in contexts such as "The only endpoint for gambling is when the gambler runs out of money. This is referred to as “playing to extinction” in the gambling-research world". It most often appears alongside Addiction by Design: Machine Gambling in Las Vegas, Amazon, American Gaming Association.

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playing to extinction
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1
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1
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May 14, 2021
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May 14, 2021
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Your Book Review: Addiction By Design
May 14, 2021 · Original source
Flow ends when the person achieves his goal. For example, a chess player experiencing flow will come out of it when the chess game ends. A surgeon experiencing flow will come out of it when the surgery ends. Gambling, unlike those activities, has no natural endpoint. Gamblers can repeat the individual games as many times as they want. There is no larger goal to build towards and achieve. The only endpoint for gambling is when the gambler runs out of money. This is referred to as “playing to extinction” in the gambling-research world.
plebs Romana1 mentions across 1 issues

plebs Romana is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between May 06, 2021 and May 06, 2021. The archive places it in contexts such as "the citizens of the city, the “plebs Romana,”". It most often appears alongside 320 AD, 476 AD, Africa.

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plebs Romana
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1
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1
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May 06, 2021
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May 06, 2021
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Your Book Review: Through The Eye Of A Needle
May 06, 2021 · Original source
...s than a modern nation-state. To be a citizen of a city was often the greatest honor in the life of a tenant farmer or a plebian. In Rome, the citizens of the city, the “plebs Romana,” were probably slightly less than half the population of the city. Yet, they were the only ones given the privileged of free grain and access to other foodstuff at redu...
...e a confederation of city-states than a modern nation-state. To be a citizen of a city was often the greatest honor in the life of a tenant farmer or a plebian. In Rome, the citizens of the city, the “plebs Romana,” were probably slightly less than half the population of the city. Yet, they were the only ones given the privileged of free grain and access to other foodstuff at reduce...
PLMNS1 mentions across 1 issues

PLMNS is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between April 17, 2023 and April 17, 2023. The archive places it in contexts such as "the current IRB system works fine for PLMNS purposes". It most often appears alongside Advarra, Amazon, Anya L.

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PLMNS
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1
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1
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April 17, 2023
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April 17, 2023
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Highlights From The Comments On IRBs
April 17, 2023 · Original source
Finally, most of the surveys in question are just a series of basic psychology scales or tasks both the worker and average SSC reader are very familiar with. I suspect many of them are administered by students as practice rather than 'serious' research. As the other poster said, rejected HITs are just any task the requestor declines for any reason. A worker's acceptance rate is extremely important - one of the few pieces of advice Amazon seems to give requestors is to filter for 98% or 99% acceptance rate. It's probably pretty reasonable for surveys - if you can't get 99 out of 100 of those filled out acceptably (assuming good faith by the requestors), maybe you should be filtered. It's also worth noting that Amazon makes communication difficult, and that rejected HITs can only be reversed for like a month - after that, they're permanently on your record. It's also probably worth restating: if a worker goes below the high 90s, they'll have access to fewer tasks, likely from less reputable requestors, and they'll need to do 100 of these to offset every rejection. And the worker is at much greater risk of being dug deeper into that hole by requestors rejecting their work in bad faith with no recourse - part of why surveys are popular is because the IRB can bludgeon requestors into accountability. Most of the surveys in question are also are the crumbs that filter through the grasping pedipalps of the hordes of workers (and their scripts). If people are seriously using MTurk to monetize their time, they're likely looking for 'batch HITs' - the sort of thing where there's hundreds or thousands of tasks that can be quickly repeated (moderating images, 3 cents for a sentiment analysis, a couple quarters to outline a car in an image, etc.) Of course, this mana from heaven rarely lasts long, and the worker always takes a risk - 'if I do 100 of these, and this is an unscrupulous requestor, well - I better have ten thousand accepted HITs under my belt.' That's why workers are so protective of their acceptance rate. Back to surveys - again as the other poster replied, most of what the average MTurk worker will see is probably a psychology study questionnaire with a series of whatever common scales, attention checks, and other tricks the worker has probably seen at least dozens if not hundreds of times by now. They often pay Amazon's princely sum of about 10 cents per (expected) minute - based on the minimum wage in whatever benighted 00s year Amazon Mechanical Turk launched. Anecdotally, it also seems like a lot of these are from students - probably just practice research by someone who likely has less experience with the platform than the worker themselves. The problem the requestor has - at least as of ~2018 - is that there is a lot of fraud with foreign workers getting access to MTurk accounts and submitting totally garbo data, often very quickly. Based purely on a 'time to complete' metric, this is hard to distinguish from a legit worker who has filled out hundreds of these and is looking to maximize how many pennies they get for their minutes. It also wasn't uncommon for workers to 'cook' such a survey - letting it sit at the end screen before submitting - just to avoid getting pinged for finishing it quickly. As for how this all ties back into Institutional Review Boards - well, yeah, griping to the IRB is often the MTurk worker's only recourse. Amazon just doesn't care, and as I recall a lot of requestors don't even know workers can contact them - and as mentioned there's a narrow time window to discuss rejected HITs before they become permanent. On the other hand, in a lot of cases this is basically a reddit mob complaining that a student doling out dimes screwed up their understanding of MTurk's arcane inner workings, and that's in the case that the workers aren't actually trying to defraud them for said dimes. 5. Comments About Regulation, Liability, and Vetocracy CatCube writes: I think the fundamental problem is that you cannot separate the ability to make a decision from the ability to make a *wrong* decision. However, our society--pushed by the regulator/lawyer/journalist/administrator axis you discuss--tries to use detailed written rules to prevent wrong decisions from being made. But, because of the decision/wrong decision inseparability thing, the consequences are that nobody has the ability to make a decision. This is ultimately a political question. It's not wrong, precisely, or right either. It's a question of value tradeoffs. Any constraint you put on a course of action is necessarily something that you value more than the action, but this isn't something people like to admit or hear voiced aloud. If you say, "We want to make sure that no infrastructure project will drive a species to extinction", then you are saying that's more important than building infrastructure. Which can be a defensible decision! But if you keep adding stuff--we need to make sure we're not burdening certain races, we need to make sure we're getting input from each neighborhood nearby, etc.--you can eventually end up overconstraining the problem, where there turns out to be no viable path forward for a project. This is often a consequence of the detailed rules to prevent wrong decisions. But because we can't admit that we're valuing things more than building stuff (or doing medical research, I guess?), we as a society just end up sitting and stewing about how we seemingly can't do anything anymore. We need to either: 1) admit we're fine with crumbling infrastructure, so long as we don't have any environmental, social, etc., impacts; or 2) decide which of those are less important and streamline the rules, admitting that sometimes the people who are thus able to make a decision are going to screw it up and do stuff we ultimately won't like. Darwin on why safetyism expanded just as the neoliberals were trying to decrease government regulation: Without the excuse of 'we were following all of the very strict and explicit regulations, so the bad thing that happened was a freak accident and not our fault' to rely on, companies had to take safety and caution and liability limitation and PR management into their own hands in a much more serious way. And without the confidence in very strict and explicit regulations to limit the bad things companies might do, and without democratically-elected regulators as a means to bring complaint and affect change, we became much more focused on seeking remedy for corporate malfeasance by suing companies into oblivion and destroying them in the court of public opinion. Basically, government actually *can* do useful things, as it turns out. One of the useful things it can do is be a third party to a dispute between two people or entities, such as 'corporations' and 'citizens', and use it's power to legibly and credibly ensure cooperation by explicitly specifying what will be considered defection and then punishing it harshly. This actually allows the two parties, which might otherwise be in conflict, to trust each other much more and cooperate much better, because their incentives have been shifted by a third party to make defection more costly. Without government playing that role, you can fall back into bad equilibrium of distrust and warring, which in this case might look like a wary populace ready to sue and decry at the slightest excuse, and paranoid corporations going overboard on caution and PR to shield from that. Meadow Freckle writes: Why can’t you sue an IRB for killing people for blocking research? You can clearly at least sometimes activist them into changing course. But their behavior seems sue-worthy in these examples, and completely irresponsible. We have negligence laws in other areas. Is there an airtight legal case that they’re beyond suing, or is it just that nobody’s tried? I don’t know, and this seems like an important question. And Donald writes: Why do we need special rules for medicine? The law has rules about what dangerous activities people are allowed to consent to, for example in the context of dangerous sports or dangerous jobs. Criminal and civil trials in this context seem to be a fairly functional system. If Doctors do bad things, they can stand in the accused box in court and get charged with assault or murder, with the same standards applied as are applied to everyone else. If there need to be exceptions, they should be exceptions of the form "doctors have special permission to do X". I do want to slightly defend something IRB-like here. When a doctor asks you to be part of a study, they’re implicitly promising that they did their homework, this is a valuable thing to study, and that there’s no obvious reason it should be extremely unsafe. As a patient (who may be uneducated) you have no way of knowing whether or not this promise is true. Every so often, someone does everything right, and something goes wrong anyway. A drug that everyone reasonably thought would be safe and effective turns out to have unpredictable side effects - this is part of why we have to do studies in the first place. If every time this happened, a doctor had to stand trial for assault/murder, nobody would ever study new drugs. Trials are a crapshoot, and juries tend to rule against doctors on the grounds that the disabled/dead patient is very sympathetic and everyone knows doctors/hospitals are rich and can give them infinite money as damages. There is no way for an average uneducated jury to distinguish between “doctor did their homework and got unlucky” and “doctor did an idiotic thing”. Either way, the prosecution can find “expert witnesses” to testify, for money, that you were an idiot and should have known the study would fail. In order to remove this risk, you need some standards for when a study is safe, so that if people sue you, you can say “I was following the standards and everyone else agreed with me that this was good” and then the lawsuit will fail. Right now those standards are “complied with an IRB”. This book is arguing that the IRB’s standards are too high, but we can’t cut the IRB out entirely without some kind of profound reform of the very concept of lawsuits, and I don’t know what that reform would look like. 6. Comments About The Act/Omission Distinction jumpingjacksplash writes: I think you've unintentionally elided two distinct points: first, that IRBs are wildly inefficient and often pointless within the prevailing legal-moral normative system (PLMNS); second, that IRBs are at odds with utilitarianism. Law in Anglo-Saxon countries, and most people's opinions, draw a huge distinction between harming someone and not helping them. If I cut you with a knife causing a small amount of blood loss and maybe a small scar, that's a serious crime because I have an obligation not to harm you. If I see a car hurtling towards you that you've got time to escape from if you notice it, but don't shout to warn you (even if I do this because I don't like you), then that's completely fine because I have no obligation to help you. This is the answer you'd get from both Christianity and Liberalism (in the old-fashioned/European sense of the term, cf. American Right-Libertarianism). Notably, in most Anglo-Saxon legal systems, you can't consent to be caused physical injury. Under PLMNS, researchers should always ask people if they consent to using their personal data in studies which are purely comparing data and don't change how someone will be treated. For anything that affects what medical treatment someone will or won't receive, you'd at least have to give them a full account of how their treatment would be different and what the risks of that are. If there's a real risk of killing someone, or permanently disabling them, you probably shouldn't be allowed to do the study even if all the participants give their informed consent. This isn't quite Hans Jonas' position, but it cashes out pretty similarly. That isn't to say the current IRB system works fine for PLMNS purposes; obviously there's a focus on matters that are simply irrelevant to anything anyone could be rationally concerned with. But if, for example, they were putting people on a different ventilator setting than they otherwise would, and that risked killing the patient, then that probably shouldn't be allowed; the fact that it might lead to the future survival of other, unconnected people isn't a relevant consideration, and nor is "the same number of people end up on each ventilator setting, who cares which ones it is" because under PLMNS individuals aren't fungible. Under utilitarianism, you'd probably still want some sort of oversight to eliminate pointless yet harmful experiments or reduce unnecessary harm, but it's not clear why subjects' consent would ever be a relevant concern; you might not want to tell them about the worst risks of a study, as this would upset them. The threshold would be really low, because any advance in medical science could potentially last for centuries and save vastly more people than the study would ever involve. The problem is, as is always the case for utilitarianism, this binds you to some pretty nasty stuff; I can't work out whether the Tuskegee experiment's findings have saved any lives, but Mengele's research has definitely saved more people than he killed, and I'd be surprised if that didn't apply to Unit 731 as well. The utilitarian IRB would presumably sign off on those. More interestingly, it might have to object to a study where everyone gives informed consent but the risk of serious harm to subjects is pretty high, and insist that it be done on people whose quality of life will be less affected if it goes wrong (or whose lower expected utility in the longer term makes their deaths less bad) such as prisoners or the disabled. The starting point to any ideal system has to be setting out what it's trying to achieve. Granted, if you wanted reform in the utilitarian direction, you probably wouldn't advocate a fully utilitarian system due to the tendency of the general public to recoil in horror. I want to stress how far we are away from “do experiments without patient’s consent” here - a much more common problem is that patients really want to be in experiments, and the system won’t allow it. This is most classic in studies on cancer, where patients really want access to experimental drugs and IRBs are constantly coming up with reasons not to give it to them. Jonas argued that all cancer studies should be banned because it’s impossible to consent when you’re desperate to survive, which isn’t the direction I would have taken that particular example in. But there are other examples - during COVID, lots of effective altruists stepped up to be in human challenge trials that would have gotten the vaccines tested faster, but the government wouldn’t allow them to participate. I would honestly be happy with a system that counts the harm of denying a patient’s ability to consent to an experiment they really want to be in as a negative, forget about any lives saved. And JDK writes: I haven't finished reading by felt compelled to comment on this: "the stricter IRB system in place since the '90s probably only prevents a single-digit number of deaths per decade, but causes tens of thousands more by preventing lifesaving studies." No. It does NOT "cause" deaths. We can't go down this weird path of imprecision about what "causing" means. I've been examining Ivan Illich, "Medical Nemesis" recently. By claiming IRBs which stop research ostensibly CAUSE death strikes me as cultural iatrogenesis masquerading as a cure for clinical iatrogenesis. […] "Might have been saved if" is not the same as "death was caused by". This seems to me to be a weird and overly metaphysical nitpick. Suppose a surgeon is operating on someone. In the process, they must clamp a blood vessel - this is completely safe for one minute, but if they leave it clamped more than one minute, the patient dies. They clamp it as usual, but I rush into the operating room and forceably restrain the surgeon and all the staff. The surgeon is unable to remove the clamp and the patient dies. I (and probably the legal system) would like to be able to say I caused the patient’s death in this scenario. But it sounds like JDK is saying I have to say the surgeon caused the patient's death and I was only tangentially involved. Here’s another example; suppose the US government bans all food production - farmers, hunters, fishermen, etc are forbidden from doing their jobs. After a few months, everyone starves to death. I might want to say something like “the US government’s ban on food production killed people”. But by JDK’s reasoning, this is wrong - the government merely prevented farmers and fishermen from saving people (by giving them food so they didn’t starve). I might want to say something like “Mao’s collective farming policy killed lots of people”. But since this is just a weaker version of hypothetical-Biden’s ban on food, by JDK’s reasoning I can’t do this. This seems contrary to common usage, common sense, and communicating information clearly. I have never heard any philosopher or dictionary suggest this, so what exactly is the argument? (JDK has a response here, but I didn’t find it especially enlightening) 7. Comments About The Applications For AI Metaphysiocrat writes: People have joked about applying NEPA review to AI capabilities research, but I wonder if some kind of IRB model might have legs (as part of a larger package of capabilities-slowing policy.) It’s embedded in research bureaucracies, we sort of know how to subject institutions to it, and so on. I can think of seven obvious reasons this wouldn’t work, but at this point I’m getting doomery enough that I feel like we may just have to throw every snowball we have at the train on the off chance one has stopping power. Zach Stein-Perlman writes: A colleague of mine is interested in 'IRBs for AI'-- he hasn't investigated it but has thought about IRB-y stuff in the context of takeaways for AI (https://wiki.aiimpacts.org/doku.php?id=responses_to_ai:technological_inevitability:incentivized_technologies_not_pursued:vaccine_challenge_trials). He's interested in people's takes on the topic. My take: my understanding is that the US can’t technically demand all doctors use IRBs. (Almost) al doctors use IRBs for a combination of a few reasons : The US government demands that everyone who receives federal funding use an IRB, and most doctors get some federal funding.
Inline links: writes, Darwin, writes, writes, writes, writes, has a response here, writes, writes, https://wiki.aiimpacts.org/doku.php?id=responses_to_ai:technological_inevitability:incentivized_technologies_not_pursued:vaccine_challenge_trials
pluralist ethic1 mentions across 1 issues

pluralist ethic is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between May 15, 2024 and May 15, 2024. The archive places it in contexts such as "a deontological or a pluralist ethic". It most often appears alongside @the_megabase, A Pan-Species Welfare State, ACX Grantees.

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pluralist ethic
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1
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1
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May 15, 2024
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May 15, 2024
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Profile: The Far Out Initiative
May 15, 2024 · Original source
Naturally, superhappiness scenarios could be misconceived. Long-range prediction is normally a fool's game. But it's worth noting that future life based on gradients of intelligent bliss isn't tied to any particular ethical theory: its assumptions are quite weak. Radical recalibration of the hedonic treadmill is consistent not just with classical or negative utilitarianism, but also with preference utilitarianism, Aristotelian virtue theory, a deontological or a pluralist ethic, Buddhism, and many other value systems besides.
Pluto1 mentions across 1 issues

Pluto is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between November 07, 2023 and November 07, 2023. The archive places it in contexts such as "Brought to / Cocytus; / turn’d to / bounty for / dolorous / Pluto". It most often appears alongside America, Ayatollah, Chris.

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Pluto
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1
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1
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November 07, 2023
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November 07, 2023
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Hardball Questions For The Next Debate
November 07, 2023 · Original source
TRUMP: Pour’ng / forth out of / Rus’s / rough woods; from / Muscovy’s / boroughs Gun-bulky / troops rush / forth on / Korsun’s / uncorrupt / country Just so / Cronus' / son, who / roosts on / lofty O- / lympus Puffs up / storm clouds / - so puff'd / up, so / smug Popov's / columns. But ho- / mologous / to long- / shoot’ng / Phöbus’s / sun-glow Just so / Korsun’s proud / corps burnt / through your / columns, o / Moscow. Frolov / Sokolov / Tsokov / Kozlov / sturdy Kutuzov Brought to / Cocytus; / turn’d to / bounty for / dolorous / Pluto. But not ours such / glory; / you, Vo- / lodomyr, / hog boughs of / honor Thus our / funds ought / not to sup- / ply you, your / jousts should go / solo.
PMS1 mentions across 1 issues

PMS is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between February 22, 2023 and February 22, 2023. The archive places it in contexts such as "he decides to focus on PMS (premenstrual syndrome)". It most often appears alongside Africa, Agin, American.

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PMS
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1
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1
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February 22, 2023
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February 22, 2023
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Book Review: The Geography Of Madness
February 22, 2023 · Original source
This image (source) of a witch stealing a man’s penis, with a box of previously-stolen penises to her right accompanies the 1411 poem “Flowers Of Virtue” in its 1486 edition. Malleus Maleficarum was published in 1486, so if the original text of Flowers Of Virtue contained the incident this picture refers to, it would predate Malleus. But the original text is written in poetic medieval German and I can’t find a good translation. When I wrote my review of the Malleus, people were surprised at the penis-stealing witch chapters. Yet nothing could possibly be less surprising; the penis-stealing witches are timeless and omnipresent. When commenters continued to doubt, I promised them this review of Frank Bures’ Geography Of Madness. II. Frank Bures is a journalist. In 2001, he came across an unusual BBC article: a mob had killed twelve people in Nigeria, believing them to be penis-stealing witches. A few months later, a similar article: five people, Benin. He tried to pitch a story about the phenomenon to his editor, who “said he couldn’t pay me to fly to Nigeria and find essentially . . . nothing”. For some reason - and this is the point at which I start to worry about narrator reliability - Bures became obsessed with this. He couldn’t get it out of his mind. He started scraping together money to visit Africa on his own, story be damned: Nigeria gnawed at me. I knew that it was a terrible time to leave. I knew that [my wife] Bridgit, newly pregnant, wouldn’t want me to go. But I also knew that I had to, and that if I didn’t it would be a lifelong regret. . . three months later, I was the lone tourist on a plane full of Nigerians descending to Lagos. Africa is a relative newcomer to penis-stealing witches: The first recorded incident of penis theft in Africa I could find took place in Sudan in the 1960s. But in the mid- to late seventies in Nigeria, there were waves of well-documented cases. One of these happened in the northern city of Kaduna, where a psychiatrist named Dr. Sunday Ilechukwu was working in his office when a policeman arrived, escorting two men. One of them said he needed a medical assessment: He had accused the other of making his penis disappear. As with [a previously discussed incident], this had caused a disturbance in the street. During Ilechukwu’s examination, he later recounted, the victim stared straight ahead while the doctor examined his penis and pronounced him normal. “Exclaiming,” Ilechukwu wrote in the Transcultural Psychiatric Review, “the patient looked down at his groin for the first time, suggesting that the genitals had just reappeared.” According to Ilechukwu, this was part of an epidemic of magical penis theft that swept through Nigeria between 1975 and 1977. “Men could be seen in the streets of Lagos holding on to their genitalia either openly or discreetly with their hand in their pockets,” Ilechukwu wrote. “Women were also seen holding on to their breasts directly or discreetly, by crossing the hands across the chest . . . Vigilance and anticipatory aggression were thought to be good prophylaxes. This led to further breakdown of law and order.” During an incident, the victim would yell: “Thief! My genitals are gone!” Immediately, a culprit would be identified, apprehended by a crowd, and often killed. …but it’s been making up for lost time. Bures was able to find and interview one previous penis theft victim, plus the friend of another. Both described similar stories: someone had bumped up against them under weird circumstances, they immediately noticed their penis was much smaller than usual, they called out the culprit, and - apparently because the witch involved didn’t want to get in trouble - their penis was restored. Whatever weird itch this topic had given Bures, this didn’t satisfy him. He writes, very lucidly, about a desire to get closer to “the story”. He started bumping up against random Nigerians in suspicious ways, hoping one of them would accuse him of stealing their penis. Bures was an obvious foreigner, and a these panics often resulted in the suspected penis-stealer getting lynched, so this was a crazy thing to do. He could easily have died. Instead, everyone politely ignored him, nothing happened, and a slightly-disappointed Bures flew back to his poor family and abandoned his weird obsession. III. …for four years. After that the bug bit him again and he flew to Asia, long a center of penis-stealing witch activity. There are nature documentaries on lions, dolphins, even dinosaurs. They all share a common pattern: you talk about your subject’s habitat, their diet, their behaviors. The Asian half of The Geography Of Madness has the feel of a nature documentary on penis-stealing witches. And the last beat of every nature documentary has to be: this majestic creature, which once roamed from one end of the region to the other, is now endangered, threatened by increasing globalization and industrial activity. This is true for the witches also. Bures’ time in Hong Kong was a bust. There was a penis theft panic there forty years earlier, and he was able to interview some of the doctors who treated it. But they all said that was long ago. Now everybody is Westernized and has Western fears like vaccine injury or structural racism. They get Western mental disorders like depression and anorexia. The idea of witches stealing their penises seems as risible to them as it probably does to you. Singapore was also a bust. Bures had hoped it wouldn’t be, because it’s full of Malaysians, and Malaysia holds a special place in history as the spot where penis-stealing witches first made contact with Western science. The Malaysian word for the condition is koro (it means “head of a turtle”, based on an analogy to the penis retracting into the body the same way a turtle’s head retracts into its shell), and it is by this name that the condition gets listed in the DSM and the rest of the medical literature. Neither I nor Bures was able to find many ethnic Malays worrying about koro; most of the activity seems to be from Malaysian-Chinese. The Chinese definitely worry about it, attributing it to a wide variety of causes including poisoning, yin-yang imbalance, and - yes - witches. But Bures found nothing among any ethnicity. Once again, all the doctors said it used to be common, but disappeared as the city industrialized and adopted Western ways. Guangzhou was also a bust. The doctors said the same thing - in the old days, there would be huge epidemics of koro, social contagions that would impact hundreds of people at once. Now only a few superstitious rural people still believed. One traditional healer said he saw “three or four” cases a year. All the educated people had moved on. I once saw a nature documentary on Tasmanian tigers. Most people believe these have been extinct since 1930. Still, there are occasional unconfirmed sightings, especially in a remote area called Cape York, and every so often some scientists trudge off to Cape York with traps and cameras in the hopes of getting lucky. Bures decides end his own nature documentary with an expedition to the Cape York of the penis-stealing witches. This is a remote island village in China called Lin’gao, where in 1984: . . . rumors spread of a fox ghost - sometimes disguised an old woman roaming the land—collecting penises in covered baskets she carried on a shoulder pole. When two young men approached her and told her to uncover the baskets, they looked inside, saw that the baskets were filled with penises and died instantly of fright. Panic about koro would hit a village and last three to four days. When residents heard about a case in a neighboring village, the panic would subside, since that meant the ghost had moved on. The attacks slowly made their way around the island. The ghost struck at night, when villagers were sleeping. A chill would creep into the room, and suddenly the victim would feel his penis shrinking inward. He would grab it and run outside for help. A twenty-eight-year-old office worker was at home one night when: > “ . . . he heard a gong being beaten and the terrifying noises made by people who were panicking in a nearby neighborhood. He suddenly became anxious and experienced the sensation that his penis was shrinking. He was seized with panic and shouted loudly for help. Several men in the neighborhood rushed in and tried to rescue him by forcefully pulling his penis and making loud sounds to chase away the evil ghost that was thought to be affecting him.” Neighbors and family members were enlisted in rescue operations. Victims were beaten with sandals and slippers while the middle finger of their left had was squeezed, so that the ghost could exit the body there. The epidemic engulfed the island, with the exception of the Li and Miao minorities, who seemed to be immune to such fears. Researchers estimated that between 2,000 and 5,000 people were affected, but that “no one died from genital retraction.” One baby, however, did die when his mother tried to feed him pepper juice, and a girl was beaten to death during a two-hour exorcism. “Numerous men suffered injuries to their penises as a result of ‘rescuing’ actions.” Iron pins were sometimes inserted through the nipples of women to prevent retraction, which caused infections as well. This was, as far as anyone knows, the last great koro epidemic in Asia. Bures had a terrible time getting to Lin’gao. He had equal trouble getting an interpreter; the natives spoke a language called Be, very distantly related to Thai but not at all to regular Chinese. Finally he found someone who was able to contact a local shaman. Like any good doctor, the shaman referred him to a specialist - in this case, the designated anti-ghost shaman, who lived in a different village. He spent most of his time off on various ghost-fighting missions, but eventually Bures and his team were able to track him down. I want you to picture the scene. An American journalist has been traveling the world in search of a dying variety of witchcraft. Now he’s reached the end of the line, the wildest and most primitive region of China. With great difficulty, he has procured an interpreter. Together, they consult a shaman, who sends them on a quest to find a second, wiser shaman who specializes in ghosts. After many trials and tribulations, he reaches the second, wiser, ghost-specialist shaman, who invites him into his home, filled with strange charms and magical images. “Tell me your question,” says the shaman. And Bures asks: “What do you know about penis-stealing witches?” . . . and the shaman answers: “Haha, no one believes in that stuff anymore.” IV. So as a nature documentary, The Geography of Madness is kind of a bust. Still, Bures rescues it with some great analysis of culture-bound mental illness. A culture-bound mental illness is one that only affects people who know about it, and especially people who believe in it. Often it doesn’t make sense from a scientific point of view (there’s no such thing as witches, and the penis can’t retract into the body). It sometimes spreads contagiously: someone gets a first case, the rest of the village panics, and now everyone knows about it / believes in it / is thinking about it, and so many other people get it too. Different cultures have their own set of culture-bound illnesses. Sometimes there are commonalities - many cultures have something something penis something witches - but the details vary, and a victim almost always gets a case that matches the way their own culture understands it. THESE PEOPLE ARE NOT MAKING IT UP. I cannot stress this enough. There are plenty of examples of people driving metal objects through their penis in order to pull it out of their body or prevent the witches from getting it or something like that. There is no amount of commitment to the bit which will make people drive metal objects through their penis. People have died from these conditions - not the illness itself, which is fake, but from wasting away worrying about it, or taking dangerous sham treatments, or getting into fights with people they think caused it. If you think of it as “their unconscious mind must be doing something like making it up, but their conscious mind believes it 100%”, you will be closer to the truth, though there are various reasons I don’t like that framing. In Rajasthan, India, people come to the hospital with gilahari (lizard) syndrome. Patients say a lizard-like mass, sometimes visible as a skin swelling, is crawling around the body. They express terror that it will reach their airway and suffocate them. Japanese people may contract jikoshu-kyofu, a debilitating fear that they have terrible body odor. No amount of reassurances by friends and psychiatrists can convince these people that they smell normal, nor will any number of deodorants or perfumes make them comfortable. The French suffer from bouffée délirante, where a perfectly healthy person suddenly becomes completely psychotic, with well-formed hallucinations and delusions - then recovers just as suddenly, sometimes over hours or days. This is not how psychosis works anywhere except France and a few former French colonies. Traditional Chinese medicine monitors the balance between yin and yang. The male orgasm can deplete yang, and sure enough in China (but nowhere else) some men suffer traditional symptoms of yang depletion after they orgasm. “The symptoms can last weeks to months after a single orgasm, [and include] chills, dizziness, [and] backache”. The phrase “run amok” comes from Malaysia, where it referred to a specific phenomenon: some person who had been unhappy for a long time would suddenly snap, kill a bunch of people, then say they had no memory of doing it. Malaysian culture totally rolls with this and doesn’t hold it against them; the unhappiness is a risk factor for possession by a tiger spirit, which commits the killings. Although Malays have been doing this since at least the 1700s, there are some fascinating parallels with modern US mass shootings that suggest the damn tiger spirits have finally made it to the US common psychological origins. I have seen exactly one demonic possession case in my ten years as a psychiatrist. The man fell to the ground, mouth foaming, chanting strange syllables and the names of Biblical demons. My attending doctor at the time - one of those people who somehow manages to be an expert in everything - was an expert in demonic possession, and told us that he was in no way psychotic, antipsychotics wouldn’t help him (except insofar as they help everyone by decreasing all behaviors), and he needed to “work through his issues”. The patient was uncooperative - he was only visiting MDs because the local bishop wouldn’t call in an exorcist until he got a psych exam - and eventually left against medical advice. After going down the list, Bures asks the correct next question: how do we know whether or not our own mental illnesses are just as culture-bound as the Japanese or Malaysians’? Cultures that believe in witches have witch-related culture-bound illnesses; cultures that believe in demons have demon-related ones. We believe in science, so we should expect sciencey-sounding culture-bound illnesses, and these might be hard to tell apart from other, more physical conditions. So how suspicious should we be, and of what? Certainly we have some culture-bound mental illnesses. Electromagnetic hypersensitivity is a condition where some people supposedly become very sick when exposed to electromagnetic fields (like from cell phones). This sounds very scientific and makes perfect sense according to our culture, but researchers have found that placebo electrical devices make them exactly as sick as real ones, and that devices they don’t know about don’t make them sick at all. These people’s pain is real, and their lives are very difficult (although a few have found refuge in the National Radio Quiet Zone, an area in Virginia where the government enforces a ban on electromagnetic transmissions for secret military reasons). But their condition only afflicts them because they believe in it, much like with koro. Fine, everyone knows that one’s not real. What about DSM-style mental disorders, the stuff everyone’s supposed to believe in? Are those culture-bound? Unfortunately, I think Bures kind of flubs this section. He decides to focus on PMS (premenstrual syndrome), which is officially included in the DSM as PMDD (premenstrual dysphoric disorder). After discussing the history of hysteria, he writes that: Today, hysteria is never diagnosed, except by unwise husbands. In 1931, however, an American gynecologist named Robert Frank revived the idea in a new guise. He published an article titled, “The hormonal causes of premenstrual tension.” Frank described symptoms that occurred in the week before menstruation: irritability, bloating, fatigue, depression, attacks of pain, nervousness, restlessness, and the impulse for “foolish and ill considered actions,” due to ovarian activity. Again, the cause was the uterus. Then in 1953, British physician Katharina Dalton elaborated on this, arguing the condition came from fluctuation of estrogen and progesterone. She called it Premenstrual Syndrome, and soon symptoms grew to include: anxiety, sadness, moodiness, constipation or diarrhea, feeling out of control, insomnia, food cravings, increased sex drive, anger, arguments with family or friends, poor judgment, lack of physical coordination, decreased efficiency, increased personal strength or power, feelings of connection to nature or to other women, seizures, convulsions, asthma attacks, not to mention flare ups in asthma, allergies, sinusitis, anxiety disorders, irritable bowel syndrome, migraines, and multiple sclerosis. If any of these symptoms occurred in the second half of the menstrual cycle, one had PMS. Estimates of the number of women afflicted ranged from 5 percent to 95 percent. In the 1980s, three women in the UK were tried for arson, assault and manslaughter. The three all claimed they had diminished responsibility due to PMS, and got reduced sentences on the condition that they underwent hormone treatment. After that, according to one study, American women flooded doctors with requests for help with their PMS. “Popular groups like PMS Action were founded to promote recognition and treatment of PMS by medical professionals. Private PMS clinics began to appear in the USA, modeled after those in the UK, and progesterone therapy was enthusiastically adopted, much to the chagrin of many gynaecologists who viewed its use as ‘unscientific’ and ‘commercial’, not to mention unlicensed." Based on all this, the 1987 version of the DSM-III included a new category: Late Luteal Phase Disorder (luteal refers to progesterone). It was proposed as a topic for further research, but despite the absence of such research, it was included in the 1994 edition of the DSM-IV under the name Premenstrual Dysmorphic Disorder, or PMDD.96 In 2013, in the DSM-5, it was given its own category as a full-fledged mental illness. Yet neither PMS nor PMDD occur in most cultures. There are no biomarkers to measure them by. No conclusive correlation has ever been found between estrogen or progesterone levels and PMS. As one study noted, “the more time that women of ethnic minorities spend living in the United States, the more likely they are to report PMDD. Thus, if we are to accept PMDD as a reified medical disorder, then we must also accept exposure to U.S. culture as a risk factor for contracting PMDD.” If it is a syndrome at all, it’s a cultural one. I asked my wife what she thought of this, and she told me: The day before her first-ever period, as a teenager, when she had never really thought about PMS, she felt exceptionally weird, emotional, and generally off, to the point where it seemed to demand an explanation. Then she had her first-ever period, and retroactively explains it as PMS.
Inline links: source, my review of the, Geography Of Madness, Be, gilahari (lizard) syndrome, jikoshu-kyofu, bouffée délirante, suffer traditional symptoms of yang depletion, run amok, Electromagnetic hypersensitivity, National Radio Quiet Zone
PNALD1 mentions across 1 issues

PNALD is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between August 06, 2021 and August 06, 2021. The archive places it in contexts such as "One of these diseases is called PNALD - Parenteral Nutrition Associated Liver Disease"; "mouse studies on the causes of PNALD". It most often appears alongside American College of Clinical Pharmacy, ASPEN, BCH.

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PNALD
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1
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August 06, 2021
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August 06, 2021
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Details Of The Infant Fish Oil Story
August 06, 2021 · Original source
Parenteral nutrition is notoriously tricky. Food has lots of different chemicals in it - vitamins, minerals, etc. Scientists haven’t discovered exactly which ones are biologically necessary, and if you forget one in your fluid then your patient will get some kind of inexplicable disease. One of these diseases is called PNALD - Parenteral Nutrition Associated Liver Disease. Lots of people on parenteral nutrition get PNALD. Some need liver transplants. Others die. Doctors assumed there was something they were missing, but they weren’t sure what.
Meanwhile, a team of researchers at the same hospital, including a certain Dr. Puder, were trying to figure out what was going on with PNALD. They pumped lab rats full of various combinations of nutritional fluid, trying to see which rats got liver disease and which ones didn’t. Dr. Gura was helping this team get their IV nutrients, and on a whim:
After this, Boston Children’s Hospital and the FDA kind of became pen pals - every time BCH got a new PNALD patient, they would ask the FDA for permission to import Omegaven from Europe, the FDA would grant it, and the patient would make a miraculous recovery. Eventually they worked together with the FDA to get something called an IND, which meant their hospital only was allowed to use Omegaven in the context of investigating and studying it.
PNUT1 mentions across 1 issues

PNUT is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between July 03, 2025 and July 03, 2025. The archive places it in contexts such as "a mutation in the PNUT gene AND ALSO grow up in a household with ... early exposure to nuts". It most often appears alongside 23andme, @alextisyoung, Aborigines.

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PNUT
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1
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1
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July 03, 2025
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July 03, 2025
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Highlights From The Comments On Missing Heritability
July 03, 2025 · Original source
Take the peanut allergy example [from a paywalled post of Lyman Stone’s]. Let's say in order to develop an allergy you need a mutation in the PNUT gene AND ALSO grow up in a household with [ed: possibly this should be “without”] early exposure to nuts (no Bamba!); that's a gene-environment interaction. For MZ twins, they will always share PNUT mutant (or wildtype) and 100% of their household exposure, so they'll be perfectly correlated on allergy; for DZ twins, they will share PNUT mutations half the time and 100% of their household exposure, so their correlation drops in half. So the twin study will tell you allergy is a 100% heritable trait. Now we test the PNUT variant in a GWAS, the first thing you do is throw away all the relatives (i.e. take one of each twin). Some people will be PNUT mutants and grow up in a household with no exposure and be allergy free, some will be PNUT mutants with exposure and will have allergy (and vice versa for the non-carriers). The resulting correlation between PNUT mutation and allergy will be low, so the heritability estimate will be <100%. TLDR: in the ACE twin model (and sib-reg), AxA and AxC interactions get counted as A. In the GWAS (and RDR) model, AxA and AxC get counted as E. In my opinion AxA could plausible be considered "heritability" in the sense that it only relies on genes, but AxC cannot.
Pocket electronic dictionaries1 mentions across 1 issues

Pocket electronic dictionaries is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between February 03, 2022 and February 03, 2022. The archive places it in contexts such as "Pocket electronic dictionaries (PEDs) were common in many Asian countries in the early 2000s". It most often appears alongside 538, 55-gal drum, 750k horny men.

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1
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1
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February 03, 2022
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February 03, 2022
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ACX Grants ++: The First Half
February 03, 2022 · Original source
#43: Pocket Dictionaries For South Africa There is an urgent need for a solution to South Africa’s literacy crisis. What we need is a school dictionary with the portability and reliability of a print dictionary, and the functionality and capacity for extra support of an electronic dictionary. Pocket electronic dictionaries (PEDs) were common in many Asian countries in the early 2000s. They were small and portable, but could contain and present more data than print dictionaries. They do not use the internet, so there are no data or connectivity costs. Once a PED is owned, it is free to use apart from battery charging. PEDs are more suitable than smart phones for primary school pupils, as these learners do not have their own phones or access to smart phones. My dissertation for my PhD in lexicography was designing model entries for an electronic primary school dictionary, with more support for pupils with features not seen in print dictionaries. I plan to develop an updated PED as a standalone dictionary device to be used by primary school pupils. Access to a reliable school dictionary with more language support will lead to better fluency and literacy, which has obvious implications for the individuals and the country. I require an initial amount of US$12000 to get the technical specs developed and a set of sample entries produced. Based on this, the next phase will be the development of a prototype for testing in schools. Please contact me on lorna@lemma.co.za for more information.
podcast1 mentions across 1 issues

podcast is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between October 25, 2022 and October 25, 2022. The archive places it in contexts such as "I don’t find the podcast interview format interesting". It most often appears alongside 80,000 Hours, ACX Grants, Andrew Ng.

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podcast
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1
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1
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October 25, 2022
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October 25, 2022
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From The Mailbag
October 25, 2022 · Original source
DEAR SCOTT: Will you go on my favorite podcast? — Garrett from Ugarit
I don’t find the podcast interview format interesting. It seems to imply that the guest either has some specific thing to talk about, or is a generally interesting person who should be interviewed about their life and opinions.
I constantly hear about podcast-related drama where someone interviewed a person who platformed a person who went on a podcast with Hitler and now everyone hates everyone involved. I don’t want to have to keep track of what podcasts Hitler went on, or denounce people who had the wrong guests on their podcast. I find everything about this tedious.
PoE21 mentions across 1 issues

PoE2 is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between January 17, 2025 and January 17, 2025. The archive places it in contexts such as "Musk faked his PoE2 accomplishments". It most often appears alongside @tamaybes, @venturetwins, A16Z.

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PoE2
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1
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1
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January 17, 2025
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January 17, 2025
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Links For January 2025
January 17, 2025 · Original source
I agree with this solution. 3: Ruxandra Teslo and Willy Chertman: The Case For Clinical Trial Abundance 4: This month in nominative determinism: NYT article calculating your chance of winning the lottery, by Victor Mather (h/t Yafah Edelman). 5: Someone is working on a dating site that uses your conversations with Claude to find a match. Link here, although so far it’s just a landing page where you can register interest (h/t @venturetwins) 6: The Lyttle Lytton Contest searches for the worst possible opening line for a novel; it’s been going on since 2001 and this year’s results are in. 7: Gary Marcus and Miles Brundage have made a bet about AI progress. I agree with @tamaybes and others in saying that Miles let Gary off too easily; Gary’s public statements all sound like “modern AI is mostly hype, it doesn’t really do anything like thinking”, but the bet is about things like “will AI make a Nobel Prize caliber scientific discovery by 2027?” and “will AI write Pulitzer-quality books by 2027?” I don’t blame Gary for taking the best terms he could find. But I am worried that if AI makes a Nobel-quality scientific discovery in 2026, but doesn’t quite write the Pulitzer-quality book, then Gary will get to claim victory over the AI optimists, whereas in fact that would be at probably the 95th percentile of fast timelines by most people’s estimate. 8: “The probability that cows (or other non-human animals) are experiencing constant bliss, lack tanha (craving, aversion, and the resulting suffering), or are "enlightened by default" is, by my estimation, very low”. 9: Recursive Adaptation (blog on addiction policy)’s predictions for 2025. 75% of FDA approval of GLP-1 for a substance use disorder by 2029! 10: In my post on the economics of GLP-1 receptor agonists (eg Ozempic), I wrote about how they’re currently widely available because of a loophole suspending patents during a shortage, and predicted there would be a big fight when the shortage was over. Sure enough, the FDA tried to declare that the shortage of tirzepatide (a next-generation Ozempic relative) was over, compounding pharmacies sued, and tirzepatide is still available while the issue goes through the courts (and will the administration have an opinion?) Also, compounding pharmacy access startup Mochi says that they will continue to prescribe even if the shortage is over, using another loophole saying doctors can do this for specific individual patients in cases of medical necessity. This is an extremely fake use of this loophole, but will the government be willing to call their bluff? 11: Jacob Falkovich has a blog on dating advice, which he plans to turn into a book of dating advice. I can’t really comment on the accuracy (my dating strategy tends to look more like waiting for women to send me emails saying “I like your blog, would you like to go on a date?” which probably doesn’t generalize), but I’ve had many good interactions with Jake, and he has a beautiful family which means he must be doing something right. Also, Jake is poly, and I sometimes wonder if poly people are the only ones qualified to give dating advice: if you’re monogamous, you either met your future spouse quickly (in which case you have no experience), dated for years without meeting your spouse (in which case you can’t be very good), or aren’t looking for a committed relationship at all (which is just pickup artistry, and follows very different dynamics). Poly people are the only ones who can break out of this trilemma! 12: Christ And Counterfactuals is a blog on effective altruism from a Christian perspective. Some previous attempts at this have felt kind of forced, but the first post I read here was actually pretty interesting. Richard Swinburne (apparently “the world’s best Christian philosopher”), thinks that: “[One] reason why it is good that the human race should sometimes be in an initial situation of considerable ignorance about the causes and effects of our actions, is this. If God abolished the need for rational inquiry and gave us from childhood strong true beliefs about the causes of things, that would make it too easy for us to make moral decisions. As things are in the actual world, most moral decisions are decisions taken in uncertainty about the consequences of our actions. I do not know for certain that if I smoke, I will get cancer; or that if I do not give money to some charity, people will starve. So we have to make our moral decisions on the basis of how probable it is that our actions will have various outcomes—how probable it is that I will get cancer if I continue to smoke (when I would not otherwise get cancer), or that someone will starve if I do not give. Since probabilities are so hard to assess, it is all too easy to persuade yourself that it is worth taking the chance that no harm will result from the less demanding decision (the decision which you have a strong desire to make). And even if you face up to a correct assessment of the probabilities, true dedication to the good is shown by doing the act which, although it is probably the best action, may have no good consequences at all.” (Could a Good God Permit so Much Suffering? A Debate, pp. 52-53.) This is pretty galaxy-brained, but something galaxy-brained must be going on for God to tolerate the existence of evil at all, and this is a surprisingly natural extension of some common premises on the subject. 13: Swedish study: diagnosing the marginal patient with a psychiatric condition makes their life worse. Of the two mechanisms they looked at, stigma seems more involved than drug side effects. My opinion: this study was done on conscripts undergoing a mandatory psych evaluation for the army, who had no previous reason to think they had a psych disease and had not sought treatment. This is a different situation from somebody who comes to a psychiatrist asking for relief from specific symptoms they have noticed. Also, Sweden c. 2005 is a different culture from America 2025 in terms of how much stigma a psych diagnosis carries. I think it’s possible that if you never considered that you had psychiatric problems, and were suddenly given a diagnosis in 2005 Sweden and told you couldn’t serve in the army, that’s likely to destabilize your self-image more than a person who knows they’re depressed going to a psychiatrist in 2025 US and getting antidepressants. 14: RIP Felix Hill, research scientist at DeepMind and mentor to many in the AI community. You can read his suicide note here, though the obvious content warning applies. He says he took ketamine for mild anxiety and it plunged him into an incredibly deep depression that he couldn’t get out of; he leaves his story behind as a warning for others. I appreciate his warning, but I wish he had said more about what dose he used; different people’s ketamine doses vary by almost two orders of magnitude, I’d previously thought that the low doses were pretty safe and the high doses were sketchy, and I would like to know whether I should update or not. 15: RIP Max Chiswick, professional poker player, effective altruist, and ACX reader. 16: Adrian Dittman, a Twitter account widely accused of being Elon Musk’s alt, has been revealed to be . . . a guy named Adrian Dittman. Congrats to Maia Crimew and the Spectator for actually investigating this, unlike many other news sources which spread the Musk conspiracy theory. Also, the people involved got banned from X for some reason, maybe because this qualified as doxxing Dittman. 17: Related: Musk claims to be among the top players in the world at several computer games. A veteran Path of Exile gamer presents evidence that Musk faked his PoE2 accomplishments by hiring a Chinese guy to play on his account. Some Musk supporters in the comments suggest that maybe he hires the Chinese guy to level up his account, but his accomplishments (eg speedruns) are still his own? 18: Related: Sam Harris says he has been friends with Musk since 2008, but he noticed a sudden shift for the worse in his personality around 2020 which made it impossible to stay friends with him. He gives the example of Musk losing a bet with him that there would be 35,000+ COVID cases in the US, refusing to pay up, and launching personal attacks on Sam when asked to do so. What happened? Some theories: Musk turned right-wing, which ended his friendship with Sam for the same reason political differences have always ended friendships (but then what about the bet, which seems like objectively bad behavior?)
Inline links: this, The Case For Clinical Trial Abundance, NYT article calculating your chance of winning the lottery, here, @venturetwins, this year’s results are in, Gary Marcus and Miles Brundage have made a bet about AI progress, @tamaybes, by my estimation, Recursive Adaptation, my post on, the FDA tried to declare, will continue to prescribe, a blog on dating advice, Christ And Counterfactuals, the first post I read here, diagnosing the marginal patient with a psychiatric condition makes their life worse, RIP, here, RIP, a guy named Adrian Dittman, got banned from X for some reason, presents evidence
poinsettias1 mentions across 1 issues

poinsettias is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between February 24, 2021 and February 24, 2021. The archive places it in contexts such as "There you will see primarily ... poinsettias". It most often appears alongside 1950s, 1980s, 1983.

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poinsettias
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1
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February 24, 2021
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February 24, 2021
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Book Review: Fussell On Class
February 24, 2021 · Original source
Anyone imagining that just any sort of flowers can be presented in the front of a house without status jeopardy would be wrong. Upper-middle-class flowers are rhododendrons, tiger lilies, amaryllis, columbine, clematis, and roses, except for bright-red ones. One way to learn which flowers are vulgar is to notice the varieties favored on Sunday-morning TV religious programs like Rex Humbard's or Robert Schuller's. There you will see primarily geraniums (red are lower than pink), poinsettias, and chrysanthemums, and you will know instantly, without even attending to the quality of the discourse, that you are looking at a high-prole setup. Other prole flowers include anything too vividly red, like red tulips. Declassed also are phlox, zinnias, salvia, gladioli, begonias, dahlias, fuchsias, and petunias. Members of the middle class will sometimes hope to mitigate the vulgarity of bright-red flowers by planting them in a rotting wheelbarrow or rowboat displayed on the front lawn, but seldom with success.
Pointy-Haired Boss1 mentions across 1 issues

Pointy-Haired Boss is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between January 21, 2026 and January 21, 2026. The archive places it in contexts such as "The Pointy Haired Boss seems to go back and forth between Clueless and Sociopath". It most often appears alongside 4chan, 80,000 Hours, @Ashwin V.

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Pointy-Haired Boss
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1
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1
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January 21, 2026
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January 21, 2026
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Highlights From The Comments On Scott Adams
January 21, 2026 · Original source
I have seen people try to walk this back by saying Adams only meant they would be persecuted in some way that was metaphorically equivalent to hunting, but I feel like “good chance you will be dead within the year” is saying he means the kind of hunting which literally kills you, and “police will stand down” means that it will be the sort of extremely illegal thing that police would normally react to. I have seen other people try to link this to examples of Republicans actually getting killed, such as Charlie Kirk. But Adams was telling his readers there was “a good chance” that “they” would be dead within a year, which I think implies this fate happening to a significant proportion of ordinary Republicans, not just one prominent person. Also, Kirk was five years after the comment was posted. Can we dismiss this as a joke? I think Adams has used the manipulation technique of saying things that might or might not be jokes and then strategically sticking to them or saying “What? Me? I was only joking! Haha! You can’t take a joke!” depending on which was more convenient to him at that exact second, enough times that I’m not comfortable letting him have that escape. Also, when I was replying to Joel Pollak about this, I happened to glance at his Twitter account, and one of the top tweets was a repost of someone saying that “The Democrat playbook is to arrest every single person who disagrees with them”. I think if I forced Pollak into some kind of extremely literal frame of mind - maybe asked him to bet money on whether I could tweet the words “the Democrats are wrong about immigration” in my Democrat-controlled state without getting arrested - he would admit that, okay, they don’t want to arrest literally every single person who disagrees with them. He was exaggerating for effect, probably in much the way he’s going to say that Scott Adams was exaggerating for effect. You say stuff like “The Democrats are going to HUNT YOU DOWN and LITERALLY MURDER YOU. They will TORTURE YOUR FAMILY and RAPE YOUR DAUGHTER and EAT YOUR PETS and TURN YOUR HOUSE INTO A CHURCH OF SATAN”, and what you mean is “I disagree with the Democrats and sometimes they go overboard cancelling people”. I have a post called If It’s Worth Your Time To Lie, It’s Worth My Time To Correct It. My thesis is that tolerating claims of “directional correctness” - the thing where someone asks to get a pass because even if they said wasn’t literally true, it “points to” an “emotionally correct” thing - is eventually totally corrosive. It means everyone ratchets up their claims to the highest level they think they can get away with (ie walk back later if challenged, as a motte and bailey). And then you end up with this miasma where maybe 5% of people totally believe you, and 50% of people sort of absorb the connotation and think something like that is true, and then people get terrified of the Democrats and think of them as monsters and treat politics as an existential struggle where they will genuinely get arrested or murdered unless they do it to the Democrats first, and then you get a civil war or something. I think Adams and Pollak’s milieu has in fact reached this point, and their love for these kinds of exaggerations is a big part of the cause. Adams was one of the funniest people in the world. If he was actually telling a joke, you could tell by the fact that you were laughing hysterically. “Democrats will hunt and kill you” isn’t funny. I’ll refrain from judgment about whether it was Adams’ sincerely held belief, some kind of annoying manipulation attempt, or whether Adams even recognized a difference between the two. But I think judging him on the fact that it didn’t happen is completely within bounds. … 3: Comments On The Substance Of The Piece … Zanzibar BuckBuck McFate writes: This business where boomers are tolerant of contradictions and find them amusing whereas millennials are horrified is a dynamic I've noticed as well, it seems to be true in politics also, I myself feel this hunger to be authentic all the time. I think it has something to do with the difficulty children have in putting negativity in context. They can't distinguish between a parent having a bad day and venting, or having an existential crisis. So the 50s guy was half right - you don't have to love your boss in your heart of hearts but careful what you say to your kids. Feral Finster writes: » “This is the basic engine of Dilbert: everyone is rewarded in exact inverse proportion to their virtue. Dilbert and Alice are brilliant and hard-working, so they get crumbs. Wally is brilliant but lazy, so he at least enjoys a fool’s paradise of endless coffee and donuts while his co-workers clean up his messes. The P.H.B. is neither smart nor industrious, so he is forever on top, reaping the rewards of everyone else’s toil. Dogbert, an inveterate scammer with a passing resemblance to various trickster deities, makes out best of all.” Compare with the famous observation that executives are sociopaths, management are clueless, and the workers losers. Yeah, it’s interesting to compare Rao and Adams. Rao formulated his Gervais Principle as a specific response to Adams’ Dilbert Principle, which I guess means Rao thought Adams got it wrong. Did he? The Pointy Haired Boss seems to go back and forth between Clueless and Sociopath, which is probably why Rao thought Adams’ work fell short. Dogbert is clearly Sociopath, but has no permanent role in the corporation, and doesn’t really represent a real thing you can be - his character was a ridiculous scammer who succeeded at near-impossible endeavours (like convincing people he was a Nostradamus-style mystical prophet) because the logic of the strip demanded it. Later, Adams foregrounded the CEO character more, maybe to create a purer Sociopath, letting the Boss go closer to Clueless. This is making me somewhat regret accusing Adams of wanting to be the Pointy-Haired Boss. It would have been fairer (and less of an accusation/surprise) to accuse him of wanting to be Dogbert. But again, Dogbert doesn’t represent a real thing you could be, which might have been why the PHB made a better metaphor. (contra my claim, the cover of Win Bigly shows a mashup of Dogbert and Trump. Fine, Dogbert is a thing one person can be.) You can read my full review of The Gervais Principle here. cincilator writes: Scott Alexander, former tribune of nerds now says that the sneerclub was right about everything all along? I didn’t expect that, let me tell you. Several people interpreted me as attacking nerds. I disagree - I think I was attacking self-hating nerds, because nerdiness is fine and you shouldn’t have to hate yourself for it. To spell it out more explicitly: All nerds must eventually realize they’re not going to immediately dominate everything by intellect alone. This isn’t because intellect isn’t great, it’s because 1) it’s only one of many skills, and 2) you probably aren’t even the person with the most intellect. Again, every mildly-talented person has to face this realization, whether it’s a nerd realizing he won’t be the next Einstein or a jock realizing he won’t be the next LeBron. If someone deals with this using denial (one of Freud’s maladaptive defenses), you get the nerd who says no, I really am the next Einstein, ie a crackpot, aka the sort of person who gets featured on Sneerclub. If they deal with it using reaction formation (another of Freud’s maladaptive defenses), you get the self-hating nerd, aka the sort of person who joins Sneerclub4. If they just deal with it maturely instead of spinning up maladaptive defenses against it, they’re a nerd who is hopefully good-natured and accepting of their nerdiness, and hopefully does some good work in some specific small area, and changes the world in some specific small way (or some very large way, if they can work together with other people and get lucky). Bugmaster writes: I think Adams is basically correct. Yes, facts and evidence do exist and are real; but they have virtually no impact on anything socially important -- i.e., on anything important whatsoever. Memes and charisma and persuasion are what matters if you want to achieve life goals that extend beyound yourself and your immediate family. I worry that Adams (and you) are doing something where unless the average person can solve every problem by facts and intelligence alone, then facts+intelligence lose and memes and persuasion win. But the average person also can’t solve every problem by memes+persuasion alone! If Dilbert is an 80th percentile nerd, the 80th percentile persuader is - I don’t know, a used-car salesman? Dilbert’s probably earning more money, especially nowadays when he could make L5 at Google. And if Donald Trump is a 99.9999th percentile persuader, the 99.9999th percentile nerd is Ilya Sutskever. Probably most people would slightly prefer being Trump to Sutskever, but Sutksever does have a couple billion dollars, plus the more ethereal rewards of genius; it still seems like a pretty good deal. I also think you’re doing a sort of black-and-white thinking here. Every day, great persuaders like Sam Bankman-Fried and Elizabeth Holmes end up in jail, because in fact the things that they said were true were not true. Every day, smooth-talking charismatic manipulators successfully seduce the girl into bed with them, then totally fail to turn it into a happy stable marriage, because after a few years even the dumbest woman catches on and figures out whether her mate provides real value or not. Even Donald Trump has only a 37% approval rating, because he can’t make “we should alienate our allies over Greenland” sound plausible to most of the American people. When someone’s very good at it, persuasion sometimes helps them blur facts around the edges. But that’s it. Nobody except Scott Adams and a few psychotherapists ever go to hypnotist school. Most don’t even go to any formal persuasion classes. That’s because hypnotism/persuasion isn’t really a lifehack that helps you win all the time at everything. If the world’s best hypnotist asked a room of VCs for money with a stupid business plan, he would probably fail. This isn’t to say persuasion is useless, and in certain fields it can be very powerful indeed. But let’s not go crazy and start worshipping it. The grass is always greener on the other side. The nerd sits in his cubicle and thinks “If only I were more charismatic.” But the salesman with the bright teeth and the firm handshake thinks “Man, I bet I could get out of this dead-end job if only I were smarter.”5 … 4: The Part On Race And Cancellation (INCLUDED UNDER PROTEST) … Ilya Lozovsky writes: Ninety percent of this essay is brilliant — smarter and realer than anything anyone else has written about Adams — but the end lost me. It's too generous, to the point of being a whitewash. Adams was vicious and hateful and played a material role in convincing Americans to vote for actual fascism. I don't think it's right to "hand it to him." JJ McCullough (JJM’s Shortstack) writes: Good essay, but I think you kinda yadda-yadda'd away his racist rant, which was extremely explicit and extended. I think it was the opposite of a "bog-standard cancellation," which we think of as being a slightly unfair, overzealous policing of an at least slightly subjectively offensive comment, often from years ago. But Scott went on quite a long diatribe about why black people, as a group, are dangerous and undesirable to be around, and why he, personally, goes out of his way to avoid them. Some conservatives have tried to use "bog-standard" anti-woke logic in defending him, but no, his comments really are quite explicitly and undeniably racist, if that term has any useful definition at all. Alex Wotbot writes: Now, you quoted Adams saying: “the best advice I would give to white people is to get the hell away from black people; just get the fuck away” If this was the intended point, does it really make sense that only the far-left freaked out? It’s kind of important to mention this was within a hypothetical. Suppose a survey reported that 26% of a population believes “The phrase ‘It’s OK to be blonde’ is hate speech” and another 21% weren’t sure if they agree with the statement or not. Now suppose you were blonde, would you hang around that population? Now go read the February 2022 Rasmussen Reports survey. Please do better than this, I don’t want to have to Gell-Mann memoryhole this. Many people had strong opinions on this, so I have to respond to it. But first, I want to make it extra clear in capital letters: I AM DOING THIS IN THE COMMENTS POST, TO RESPOND TO YOUR COMMENTS, AND NOT BECAUSE I THINK IT IS THE MOST IMPORTANT THING. Certain people screenshotted the one paragraph of my ten thousand word essay that discussed this and posted it on Twitter, in order to make it look like I was joining in some kind of chorus of liberals reducing Adams to his worst moment. I posted what I thought was a no-nonsense, factual description of what happened, in order not to be accused of hiding it or covering it up. It was the least important part of my essay, I’m aware that writing about it at all opens me to attack from both sides, and I discuss it here only to respond to all of you who wanted to know my opinion on it. Just don’t screenshot it on Twitter and say “LOOK SCOTT IS STILL HARPING ON THE RACE THING”, that’s all I’m asking. That having been said… To make sure we’re all on the same page - Adams’ comments were prompted by this poll, conducted February 2023. The question was: “Do you agree or disagree with this statement: ‘It’s OK to be white’” Among blacks, 53% agreed, 26% disagreed, and 21% were “not sure”. Among whites, the numbers were 81/7/13. Here’s the video of Adams’ comments: Transcript: If nearly half of all blacks are not okay with white people - according to this poll, not according to me - that’s a hate group. And I don’t want to have anything to do with them. And I would say, based on the current way things are going, the best advice I would give to white people is to get the hell away from black people. Just get the f**k away. Wherever you have to go. Just get away. Cause there’s no fixing this. This can’t be fixed. You just have to escape. That’s what I did. I went to a neighborhood with a very low black population. Because unfortunately, there’s a high correlation between the density - this is according to Don Lemon, here I’m just quoting Don Lemon, who said when he lived in a mostly black neighborhood, there were a bunch of problems he didn’t see in white neighborhoods. So even Don Lemon sees a big difference, for your quality of living, based on where you live and who’s there. So I think it makes no sense whatsoever as a white citizen of America to try to help black citizens anymore. It doesn’t make sense. Because there’s no longer a rational impulse. And so I’m… I’m gonna, uh, I’m gonna back off from being helpful to black America, because it doesn’t seem like it pays off. Like I’ve been doing it all my life, and I’ve been… the only outcome is I get called a racist. That’s the only outcome. [cackles] It makes no sense to help black Americans if you’re white… it’s over. Don’t even think it’s worth trying. Totally not trying. Is this racist? I have a piece called Against Murderism, where I talk about why it’s so hard for people to agree on questions about “racism”. The summary: although it would be possible to have someone be purely, axiomatically racist - having it be a premise of their reasoning that they hate black people - in practice few people are like this. More typically, people have some argument more like: I don’t like [specific bad thing]
Inline links: https://substackcdn.com/image/fetch/$s_!KA_U!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fa2cb6162-0262-4c4c-8048-e8355f38967a_900x280.gif, If It’s Worth Your Time To Lie, It’s Worth My Time To Correct It, writes, writes, the famous observation that executives are sociopaths, management are clueless, and the workers losers, The Gervais Principle, writes, 4, writes, 5, writes, JJM’s Shortstack, writes, writes, this poll, Against Murderism
Pokemon1 mentions across 1 issues

Pokemon is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between January 16, 2025 and January 16, 2025. The archive places it in contexts such as "The third-graders I know are very into Pokemon". It most often appears alongside Afghanistan, Africa, African small-plot subsistence agriculture.

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Pokemon
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1
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1
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January 16, 2025
Last seen
January 16, 2025
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Highlights From The Comments On Lynn And IQ
January 16, 2025 · Original source
(source) … sub-Saharan Africa is also a hot spot. I wonder what’s wrong in Cuba - this is exactly the sort of easily gameable metric I would usually expect them to be good at, or at least carefully faking. If you’re interested, you can donate to Iodine Global Network here. Bob Jacobs writes: > His opponents pointed out both his personal racist opinions/activities That's the mildest possible way you could've put it. He wasn't someone who had "personal racist opinions" that he kept as "personal racist opinions". He was the editor-in-chief of Mankind Quarterly, a white supremacist journal that was founded by people like: Henry Garrett an American psychologist who testified in favor of segregated schools during Brown versus Board of Education, Corrado Gini who was president of the Italian genetics and eugenics Society in fascist Italy, and Otmar Freiherr von Verschuer who was director of the Kaiser Wilhelm Institute of anthropology human heredity and eugenics in Nazi Germany. He was a member of the Nazi Party and the mentor of Josef Mengele, the physician at the Auschwitz concentration camp infamous for performing human experimentation on the prisoners during World War 2. Mengele provided for Verschuer with human remains from Auschwitz to use in his research into eugenics. It's funded by the pioneer fund, an organization he was a board member of and that has been classified as a white supremacist hate group, with one of its first projects being to fund the distribution in US churches and schools of "Erbkrank", a Nazi propaganda film about eugenics. He's not just called racist, he *is* racist, he even describes *himself* as a racist. No contesting any of this. MM writes: I spent 18 months in a country where people are supposed to have an iq of about 70, according to the map. My neighbors and friends were mostly non-literate. They did not seem less intelligent than the people I know in my current (US) neighborhood or the people I grew up with (in the US). Most of them would not have performed well on IQ tests, though. They'd never attended school and had no familiarity with puzzle-solving. This was 35 years ago and most people had not seen movies or even photographs. I remember sitting with one older woman and helping her interpret a black-and-white photograph: this is the arm, here's where it connects to the body, etc. It's hard for people from literate societies with tons of exposure to text & graphical representations to see the extent of the gap. Calvin writes: I have a decent amount of experience with the intellectually disabled, and saying "cognitive issues are only responsible for a small part of the [communication] deficit" is so wrong that it makes me question everything else in this essay. Trust me, even making allowances for poor hearing or difficulty forming words, the cognitive issues are responsible for 90% of the deficit. An IQ of 60 is really low and it's a significant handicap. I was concerned to hear this - I have a little experience with the intellectually disabled, but it didn’t involve knowing people’s exact IQ, so I’m not very well-calibrated here. Looking for more information, I found https://www.hrw.org/reports/2001/ustat/ustat0301-01.htm, which purports to describe the characteristics of very low IQ people, mostly in the context of criminal justice (where lawyers often try to use a client’s low IQ as a mitigating factor - ie maybe he didn’t truly understand that crime is wrong). The report says things like: Although all persons with mental retardation have significantly impaired mental development, their intellectual level can vary considerably. An estimated 89 percent of all people with retardation have I.Q.s in the 51-70 range. An I.Q. in the 60 to 70 range is approximately the scholastic equivalent to the third grade […] Although mental retardation of any degree has profound implications for a person's cognitive and social development, it is a condition which in many cases is not readily apparent. While some of the mentally retarded, such as those whose retardation is caused by Down's syndrome or fetal alcohol syndrome, have characteristically distinctive facial features, most cannot be identified by their physical appearance alone. Unless their cognitive impairment is unusually severe (e.g. an I.Q. below 40), persons with mental retardation may be thought of as "slow" but the full extent of their impairment is often not readily appreciated, particularly by people who have limited contact with or knowledge of them, including police, prosecutors, judges, and other participants in the criminal justice system. Many capital offenders with mental retardation did not have their condition diagnosed until trial or during post-conviction proceedings. And gave some examples (slightly out of order for this list): Oliver Cruz, who was executed in Texas on August 9, 2000, had an I.Q. that was measured variously at 64 and 76. Cruz nonetheless insisted to reporters that, although he was perhaps "slow in reading, slow in learning," he was not mentally retarded. Mitigation specialist Scharlette Holdman recalled a client who so successfully hid his retardation from his attorneys that he allowed them to sign him up for college-level calculus classes, which he could not comprehend. He had gone through much of his schooling allowing his younger sister to complete his homework for him. When he was given papers to read in connection to his case, he would carefully stare at them. If he was asked a substantive question, he usually responded, "I don't recall." Only when experts in retardation evaluated him and investigators reviewed his school records and spoke to his family did lawyers discover he had mental retardation and had been considered "slow" since his early childhood. Another capital defendant "hid his mental retardation for most of his life by working at a very repetitive job as a switcher on the railroad. He lied about finishing high school. He was actually in special education classes and did not finish the sixth grade. He was drafted into the army and discharged because of his mental retardation. He lied about his service record. He often made things up so that people would not suspect mental retardation." Morris Mason, whose I.Q. was 62-66, was executed in 1985 in Virginia after being convicted of rape and murder. Before his execution, Mason asked one of his legal advisors for advice on what to wear to his funeral As one psychiatrist testified about a capital defendant with an I.Q. of between 35 to 45: "[People with mental retardation try] to go along with people that they suspect are in authority. For example, I asked [the defendant] where we were when I saw him, and he obviously didn't know, so I asked him if we were in Atlanta and he said `Yes, we are in Atlanta.' In fact, we were in Birmingham, Alabama. I could have said New York and he would have said `Sure, New York' These people are obviously not going to win Nobels anytime soon. But even the guy with IQ 35 - 45 was still talking to people. I think this supports the thesis that intellectually disabled people without specific syndromes can seem pretty normal most of the time. (though keep in mind that anything from the court system should be treated with a grain of salt - defense attorneys have an incentive to exaggerate the intellectual disability of their clients in the hopes that it gets them a lighter sentence) Lyman Stone writes: Emil's post isn't correct, however. We know from the recent Reich lab paper on long-run genetic selection that there was strong selection for IQ in the neolithic revolution, which implies agriculture strongly selects for IQ and ability to plan. Malawians are 60-80% subsistence farmers. Even a "normal" low-IQ person cannot do the implied math and long-term planning involved in this kind of farming. And in fact, economists routinely find that African small-plot subsistence agriculture is actually highly optimized; farmers make very precise choices about where to plant which seeds, which fertilizer to use, etc. Key point is basically: it really isn't true that an IQ 60 person can run a farm functionally. Moreover, mean IQ of 60 implies large shares even lower, at ranges that are uniformly nonverbal even without specific disability. And this is why in the actual record-level NIQ database, they truncate estimates below 60, because even the database managers realize these estimates are crazy. See my post here: https://substack.com/home/post/p-154757665 We know that people with extremely low IQs in the Flynn sense must be capable of subsistence agriculture, because pre-Flynn Effect, most of the West had extremely low IQs, and they were all doing subsistence agriculture. How is this possible? Responding to Lyman’s comment, I wrote: I stick to the claim in this post - that our estimates for what a very low IQ means are poorly-grounded, and that people with low IQs can do some pretty impressive things, especially if they're concrete and part of a cultural transmission package. Maybe this is the Joseph Henrich "Secret Of Our Success" thing. We know that Malawians get poor test scores in school, so it seems like there's some disconnect between do-well-on-tests intelligence and run-a-subsistence-farm intelligence, and the abstract/concrete and novel/cultural distinctions are the best explanation that I can think of. You say that "the phenotype that arises from a given tested IQ in America is clearly vastly worse than the phenotype arising from the same tested IQ in Africa", which I basically agree with. I think part of it is the syndromes issue raised above, and part of it is that maybe Malawians have zero contact with the culture of abstraction that IQ tests come out of whereas even very uneducated Westerners have some contact with it, and maybe another part of it is that whatever health/nutrition issues the Malawians have preferentially harm faculties responsible for more abstract tasks rather than more concrete ones. For an opposite data point, when I was in Haiti, my boss told me (secondhand, no personal experience) of extreme difficulties working with Haitians, like that they couldn't alphabetize files even when that was explained to them. Many Haitains are also successfuly subsistence farmers, so I think this also supports some kind of heavy abstract/concrete distinction. I don't think we're really disagreeing, just agreeing on something like the correlations that make up IQ being less valid outside the normal range. Maybe one way to look at it is to go back to the claim from the justice system document above, saying that people with IQ in the 60s are the mental equivalent of third-graders. The third-graders I know are very into Pokemon, and have all sorts of opinions on how if you add X bonus to a Y strength fire-type Pokemon and then play Z combo, it will [commence six weeks of droning on about different Pokemon cards]. Is this the sort of math/reasoning/strategizing that we don’t expect someone with IQ 60 to be able to do? Does the fact that third-graders can do it mean that we’re miscalibrated? I’m not sure. The part of Lyman’s comment that gives me the most pause is his observation that, if the mean IQ is 60, a decent fraction of people must be 45, and a non-negligible portion 30. At this point, even third-grader comparisons don’t save us. I guess this is where I bring in the claim that IQ breaks down as a guide to practical living skills below some point. You can see several more layers of response between me and Lyman here, but I was especially grateful for him teaching me two things I didn’t already know: First, he corrected my misconception about Reich on ancient European cognitive evolution. Reich had said that pre-agriculture Europeans were “2-3 standard deviations” below moderns. I had interpreted that as IQ deviations of 15 points, making them genetic IQ 55-70, which would have been pretty crazy. Stone tells me he actually meant PGS deviations, each of which was about 3-4 IQ points, so he’s claiming that pre-agriculture Europeans had genetic IQ of 90 (they probably also had lower IQ for environmental reasons).,
Inline links: source, donate to Iodine Global Network here., writes, writes, writes, https://www.hrw.org/reports/2001/ustat/ustat0301-01.htm, writes, https://substack.com/home/post/p-154757665, here
poker1 mentions across 1 issues

poker is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between May 14, 2021 and May 14, 2021. The archive places it in contexts such as "table games like poker, blackjack, and roulette". It most often appears alongside Addiction by Design: Machine Gambling in Las Vegas, Amazon, American Gaming Association.

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poker
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1
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May 14, 2021
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May 14, 2021
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Your Book Review: Addiction By Design
May 14, 2021 · Original source
But machine gambling is not like other kinds of gambling. The book overflows with metaphors straining to describe how machine gambling is the supercharged version of table games like poker, blackjack, and roulette. Machine gambling is deforestation ruining the rainforest of diverse table games. Machines are invasive kudzu outcompeting and killing the native table games. Machine gambling is the crack cocaine to table games’ cocaine.
Schüll explicitly makes the comparison to Csikszentmihalyi’s flow. Flow requires four elements: sub-goals, clear rules, immediate feedback, and challenge-skill balance. Gambling offers at least the first three. Playing through each individual game is a sub-goal. Each game has clear rules: bet money and press spin. Each game only takes a few seconds, offering immediate feedback. The last element, challenge-skill balance, is not fully present in gambling. Gamblers can increase the challenge of the games by playing more lines on slot machines, or by graduating to games that require more skill, like video poker. Still, gambling doesn’t exactly require “skill,” per se, but gamblers manage to achieve flow even without that element.
You might remember the gamification craze from the beginning of this decade. App creators were convinced that adding badges, randomness, and leveling up to any activity would make it irresistible. We were promised a new world where the power of gaming would be used for good. We would all chase after more steps with our Fitbits, more languages with Duolingo, and more math with Khan Academy. Move aside Portal and poker, there were new sheriffs in town.
Pokot1 mentions across 1 issues

Pokot is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between July 15, 2025 and July 15, 2025. The archive places it in contexts such as "Among the Pokot of Kenya, where brutal wifebeating was the norm". It most often appears alongside Aboriginal, Aboriginal Australia, Aboriginal society.

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Pokot
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July 15, 2025
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Book Review: Arguments About Aborigines
July 15, 2025 · Original source
Among the Pokot of Kenya, where brutal wifebeating was the norm, men often reported they only trusted food prepared by their mothers or sisters; their wives might poison them. Others said their wives were trying to kill them by witchcraft. Several women agreed that yes, they certainly were, and one woman told the ethnographers she had succeeded.
Polar Eskimos1 mentions across 1 issues

Polar Eskimos is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between April 06, 2023 and April 06, 2023. The archive places it in contexts such as "among the Polar Eskimos such a person might be killed". It most often appears alongside Alaska, Alaskan government, Andamanese.

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Polar Eskimos
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1
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April 06, 2023
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April 06, 2023
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Book Review: The Arctic Hysterias
April 06, 2023 · Original source
Freuchen mentioned a young man who expressed his loneliness for his wife to other men while hunting. He was accordingly ridiculed and told “to stay at home and sew and care for the lamps, or employ your mouth for the talk of men.” One man in the group decided to emphasize the predicament of the lamenter by taking his wife away from him. He was told that if he were lonely enough to want her back, he should figure out how to retrieve her. Overt aggression was not customarily expressed by the Eskimo. In past years, an angry man was considered a mad man, and among the Polar Eskimos such a person might be killed (Shackleton 1939:136). Thus, the young man withdrew and cried for three days. His own abducted wife laughed at him and chided him for his weakness. He then decided that he could no longer live with his people and went to live alone inland as a hermit. He became a qivitoq - a ghost who may never return home.
Polaris1 mentions across 1 issues

Polaris is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between June 17, 2022 and June 17, 2022. The archive places it in contexts such as "Their next experiment, Polaris, should be a medium experiment". It most often appears alongside Alcator C-Mod, Apollo Program, ARC.

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Polaris
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1
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June 17, 2022
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June 17, 2022
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Your Book Review: The Future Of Fusion Energy
June 17, 2022 · Original source
Marvel gets fusion by 2035 (30%). Honorable Mention: Helion Helion is the most serious of the previous generation of fusion startups that I dismissed above. They are using an entirely different strategy from the rest of the fusion community. It is closer to Magnetic Confinement Fusion, but it does occur in discrete shots. There isn't anything obviously wrong with it, but they can't build on the progress of Figure 3. Instead, they're working on their own experimental program. They're on their 6th prototype, Trenta. It is a small experiment which can do 1 shot every 10 minutes. Their next experiment, Polaris, should be a medium experiment which can do 1 shot/second. They claim that it will get fusion by 2024. One good thing about Helion is that they have a more efficient way of directly converting the energy in the plasma into electricity. One bad thing is that they claim to be using helium-3 as a fuel. This is harder than D-T fusion [23] and it doesn't fully represent what they're planning. Their entire fuel cycle involves 50% D-D fusion, 25% D-T fusion, and 25% D-He3 fusion. Helion is also notable because they've gotten more private funding than any company other than Commonwealth Fusion Systems. I'm more skeptical. At least it seems unlikely that they will get fusion on their first medium experiment, especially since that requires improvements of multiple orders of magnitude in both triple product and shot frequency. They should expect to design an 8th experiment based on what they learn from Polaris. Helion gets fusion by 2025 (5%) or 2030 (20%).
Poles1 mentions across 1 issues

Poles is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between June 14, 2021 and June 14, 2021. The archive places it in contexts such as "why didn't Germans, or Poles, or Italians". It most often appears alongside Adam Sandler, Albert Einstein, America.

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Poles
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1
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Contra Smith On Jewish Selective Immigration
June 14, 2021 · Original source
Also, why should Jews be special here? Every immigrant group has come to America seeking a combination of economic opportunity and political/religious freedom. If Jews selectively immigrated, why didn't Germans, or Poles, or Italians, or all the other groups that didn't end up with the same kind of achievements Jews did? I think the strongest argument you could make here is that Germans/Poles/Italians were coming more for economic opportunity (and so it was mostly the poor who emigrated) whereas Jews were coming more for political/religious freedom (and so it was mostly the rich), but no, Jews mostly came for economic reasons too. Although their economic plight was in large measure caused by discrimination, it still mostly affected the lower classes, who have the least cushion for discrimination-inflicted economic costs.
Inline links: Jews mostly came for economic reasons too
police militarization1 mentions across 1 issues

police militarization is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between May 24, 2022 and May 24, 2022. The archive places it in contexts such as "he supports police militarization". It most often appears alongside #Abolitionist, #AntiNazi, #antiwar.

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police militarization
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1
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May 24, 2022
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May 24, 2022
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California Gubernatorial Candidates From Z to Z
May 24, 2022 · Original source
…including some which surprised me. He’s pretty angry about the police in a lot of ways, thinks they’re prosecuting victimless crimes and contributing to a culture of mass incarceration - but also, he supports police militarization, because:
police reform1 mentions across 1 issues

police reform is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between March 03, 2021 and March 03, 2021. The archive places it in contexts such as "on police reform". It most often appears alongside 9-11, Argentina, Austin Allred.

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police reform
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March 03, 2021
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Links For March
March 03, 2021 · Original source
16: Via MR, on police reform: "For investigations that were not proceeded by 'viral' incidents of deadly force, investigations on average led to a statistically significant reduction in homicide and total crime. In stark contrast, all investigations that were preceded by “viral” incidents of deadly force have led to a large and statistically significant increase in homicides and total crime." I’m interpreting this to mean that there are effective ways to reform the police, but that the atmosphere created by media saturation and protests produces ineffective counterproductive reform instead.
Inline links: MR
Polistes1 mentions across 1 issues

Polistes is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between August 18, 2023 and August 18, 2023. The archive places it in contexts such as "On the other hand, Polistes wasps live in small colonies, and invest heavily into face recognition". It most often appears alongside Anil Seth, Astralcodexten Com, Being You.

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Polistes
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August 18, 2023
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August 18, 2023
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Your Book Review: The Mind Of A Bee
August 18, 2023 · Original source
On the other hand, Polistes wasps live in small colonies, and invest heavily into face recognition. This is because to determine their place in the colony hierarchy, Polistes wasps have fights. It’s useful to be able to recognise faces to learn the hierarchy - if I’m Wasp A, and I lose to Wasp B, and Wasp B got pancaked by Wasp C, I probably shouldn’t fight Wasp C.
political correctness1 mentions across 1 issues

political correctness is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between May 07, 2024 and May 07, 2024. The archive places it in contexts such as "The previous incarnation of woke was called political correctness". It most often appears alongside affirmative action, Africa, African National Congress.

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political correctness
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1
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1
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May 07, 2024
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May 07, 2024
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Highlights From The Comments On "The Origin Of Woke"
May 07, 2024 · Original source
The previous incarnation of woke was called "political correctness" and it existed in late 80s-early 90s. That's when Alan Bloom's book came out. PC suffered a setback when Bill Clinton really wanted to win the election in 1992 and, needing the white vote, came down on Sister Souljah. A period of return to normalcy followed, until the recrudescence of PC as woke in late 00s.
Political Economy1 mentions across 1 issues

Political Economy is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between April 16, 2021 and April 16, 2021. The archive places it in contexts such as ""As a 19th century treatise of Political Economy"". It most often appears alongside "The Rent Is Too Damn High!", 16th amendment, 1886.

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Political Economy
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1
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April 16, 2021
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Your Book Review: Progress And Poverty
April 16, 2021 · Original source
This is a golden opportunity to shamelessly over-use the catchy phrase "By George!" If I had to summarize the book in a single sentence I would put it this way: Poverty and wealth disparity appear to be perversely linked with progress, The Rent is Too Damn High, and it's all because of land. The Book as a Book Progress and Poverty is quite readable compared to other 19th-century economic tomes, but has a tendency to repeat itself. This isn't without purpose – George goes to great pains not to be misunderstood; rather than expecting his readers to tease out the meaning of dense prose and spending the next century arguing with each other about what he "really meant", he goes on for pages and pages beating a single concept to absolute death, just to be sure. As a 19th century treatise of Political Economy, the book doesn't match what a modern reader might expect from a book on Economics because it's not packed to the gills with charts, graphs, tables, and statistics (though it does provide a good number of citations and figures). Nevertheless his argument was compelling enough to spawn an entire economic school of thought known variously as Georgism or Geoism that persists to this day. Nowadays Georgism gets slapped with the "heterodox" label, but it's still relevant enough to get the likes of Paul Krugman and Milton Friedman to grudgingly agree to key points, and Friedrich Hayek is alleged to have been inspired by it to pursue economics in the first place. Marx, on the other hand, wasn't a fan, seeing it as a last-ditch attempt "to save capitalist domination and indeed to establish it afresh on an even wider basis than its present one... [George] also has the repulsive presumption and arrogance which is displayed by all panacea-mongers without exception." I guess you can't please everyone. George spends the first few books of Volume I establishing terms and methodically tearing apart the prevailing economic theories of his day before presenting his own alternative theories about how the "three factors of production" – land, labor, and capital – relate to each other in the "laws of distribution." He then explains why the existing system causes poverty to advance alongside progress, and why we see industrial depressions. Then, he identifies the root cause of the problem (land ownership and speculative rent) and presents his solution (the Land Value Tax) in Volume II. He spends the entire second volume explaining why it is moral and just, how it should be applied, and why it will solve all of our problems. For the sake of the reader's attention span, I'll just cover the chapters that constitute the core of George's philosophy. For sections I gloss over, I'll include a brief summary of the main point followed by a jump link to an appendix at the end of the article for those who want more detail. All block quotes are from Progress & Poverty unless otherwise marked. Special thanks to my friend Adam Perry for helping me edit this piece, as well as to Nate Blair and blogger BlueRepublik (who have actual degrees in this sort of thing) for fact checking and answering my technical questions in the vain pursuit of not embarrassing myself. Alright, let's dive in. 0. The Problem George opens by observing an unkept promise made by Industrialists: it was expected, that labor-saving inventions would lighten the toil and improve the condition of the laborer. Industrialization should have freed humankind from drudgery and want. And yet George instead sees: complaints of industrial depression; of labor condemned to involuntary idleness; of capital massed and wasting; of pecuniary distress among business men; of want and suffering and anxiety among the working class If we finally have the necessary material conditions and technology for utopia, why this suffering, waste, and inefficiency? And what's the deal with industrial depressions? How can there be periods where laborers desperately want to work but can't find employment at the very same time capital sits around in useless piles, begging to be put to productive use? Contra popular explanations at the time, George argues it "can hardly be accounted for by local causes" such as military expenditures, tariffs, type of government, dense vs. sparse populations, or paper money vs. hard currency. This is because he sees the same basic problem everywhere no matter how different the countries themselves are. Behind all of these troubles George says there must lie a common cause. Pulling no punches, the man lays the blame at the feet of progress itself: that poverty and all its concomitants show themselves in communities just as they develop into the conditions toward which material progress tends - proves that the social difficulties existing wherever a certain stage of progress has been reached, do not arise from local circumstances, but are, in some way or another, engendered by progress itself This is a pretty bold claim: namely, that the resilience of poverty, oppression, and inequality in the face of advancing economic development is not some embarrassing accident we'll eventually get around to fixing, it's an inescapable consequence of our socioeconomic system. A Brief Interlude from the Future It's been over 140 years since he wrote the book, so let's hop in my time machine and see how much of George's complaint is still relevant. Back then, the United States was still in the throes of the Long Depression, which according to the shortest estimate lasted from 1873 to 1879. Below is a graph (source) of the boom-bust business cycle going back to the 1870's - clearly, recessions were much more frequent and severe in George's time than they are today. The late 1800's were wracked with so many panics and crises in quick succession that some historians count the Long Depression as lasting for a full 23 years from 1873 to 1896! After the Great Depression in the 1930's, we see a sharp decrease in the duration and frequency of recessions. They're still with us now (and the one we're currently in is the worst since the Great Depression), but you'd still rather be living in 2021 than 1879. So, have we solved the problem? Is George's complaint obsolete? I mean, this graph of GDP per capita from Stephen Pinker's Enlightenment Now makes it look like in many ways things are getting better: And heck, extreme poverty has been going down everywhere: But this can't be the entire picture, or nobody would be complaining about poverty and inequality. Here - this graph (source), shows that as consumer goods have gotten cheaper in the United States, health care, higher education, child care, etc., have skyrocketed in price, which Scott examined in great detail in Considerations on Cost Disease. And what about Inequality? In the USA it seems to have reverted to levels not seen since the Great Depression, and even when it was at its lowest in 1978, the top 0.1% (not even the top 1%!) still enjoyed a massively disproportionate share of Wealth (source): And of course, The Rent Is Too Damn High: (source): (source): Although 2021 seems better than 1879 in absolute material terms, George's complaint still rings true: healthcare and higher education are increasingly unaffordable, inequality is as bad as it ever was, and The Rent Is Too Damn High. And even if all of these measures had improved as well, we still have to contend with a fundamental complaint: how can human civilization have piled up an amount of wealth best described as absolutely banana pants insane, and yetstill have poverty, oppression and cyclical recessions? Yes, greed, evil, and human nature will always be with us, but isn't it weird that we haven't eliminated these economic problems the same way we've eliminated Smallpox, Scurvy, and having to write your scathing polemics about Thomas Jefferson by candlelight with a goose feather? Giving the mic back to George, he closes the chapter with this haunting quote, first written 142 years ago: If there is less deep poverty in San Fran Francisco than in New York, is it not because San Francisco is yet behind new York in all that both cities are striving for? When San Francisco reaches the point where New York now is, who can doubt that there will also be ragged and barefooted children on her streets? I'll just leave this here: Number of Homeless Children in U.S. At All-Time High; California Among Worst States. I. Wages and Capital George insists sloppy terminology leads to sloppy thinking. Naturally, he spends an entire chapter beating words to death to correct this. The Meaning of the Terms Let's start with Wealth. The common usage, both then and now, is "anything with an exchange value." George doesn't like how this mixes dissimilar things. By George, what is wealth? Wealth is produced when Nature's bounty is touched by human labor resulting in a tangible product that is the object of human desire. Labor is required, but the amount and type doesn't matter - George offers the example of simply picking a berry off a bush as an act that transforms nature's gifts into human wealth. Note particularly that human desire is an important requirement of wealth; it doesn't matter how much work someone put into something, if it doesn't gratify human needs or desires in some way, it's not wealth. Speaking of human desire, let's talk about Value. Where does a thing's value come from? The prevailing theory of the day was the Labor Theory of Value which originated with Adam Smith and David Ricardo, which says that Labor is the source of value. The early formulations were a bit ambiguous, here's Smith in Wealth of Nations for instance: The value of any commodity ... is equal to the quantity of labor which it enables him to purchase or command. Labor, therefore, is the real measure of the exchangeable value of all commodities. So... is a thing's value how much labor it takes to make the thing, or how much labor someone's willing to exchange for the thing? Nowadays Labor Theory of Value is most commonly associated with Marx. Marx picks a lane and says the value of something is tied to the amount of "socially necessary labor" required to produce it. George goes the other way: It is never the amount of labor that has been exerted in bringing a thing into being that determines its value, but always the amount of labor that will be rendered in exchange for it. - Henry George, The Science of Political Economy, p. 253 In other words, "a thing's value is whatever someone is willing to pay for it." This is in line with the so-called marginal revolution (the movement, not the blog) and modern theories of value. Labor Labor is the exertion of human beings. It's possible to labor to no avail (try punching a concrete wall), but typically humans labor towards an end, such as gaining wealth. But whether or not we accomplish anything with our efforts, George calls them labor. Labor isn't just making things, by the way – it's also moving or exchanging them. Production Production is labor applied "to the production of wealth." You know, productively. This is all human exertion that isn't punching a concrete wall and rewards you for your efforts with something that fits the definition of wealth. Said wealth is the "product of labor." Wages whatever is received as the result or reward of exertion is "wages." No distinction here is made between blue-collar work and white-collar work – whether one is called "hourly pay" and the other is called "annual salary," George calls them both "wages." It doesn't matter whether you receive them from your boss, from customers, or from nature. If you do work and get something from it, you have received "wages." With those basics under our belt, let's circle back to Wealth: What are some examples of wealth? By George, Gold is wealth. Teddy bears are wealth. Tesla roadsters and candy canes and young adult vampire romance novels are wealth. The same goes for fish you've caught, deer you've hunted, and cool looking rocks you've picked up on your morning walk. The value of these things may differ, but as long as they're tangible, originate in nature, someone ever did a lick of work to make or acquire them, and a human being somewhere desires them for any reason, they're wealth. It gets a little clearer when we ask what isn't wealth. And by George, Money isn't wealth. Articles of gold are wealth because they're tangible things that have been dug up, crafted, and fulfill certain human desires. But paper currency, digital currencies, and other things that aren't inherently valuable but merely represent value are not wealth (outside of putting their physical articles in coin collections or making paper airplanes, and so forth). Now don't get the man wrong, these things are certainly valuable. They're just not wealth. They are certificates that represent claims on wealth. For any computer programmers in the audience, money is a pointer to wealth. Likewise Stocks and Bonds and other financial instruments are not wealth. These are also just claims on wealth. A creditor's title to Debt isn't wealth, either, it's just a claim on the debtor's (typically future) wealth. And, writing as he was not long after the Civil War, George points out that Slaves are not wealth either but, represent "merely the power of one class to appropriate the earnings of another class." Wealth, thus defined, is the terminal "ground truth" bits of the economy, and all the financial layers on top are fancy IOUs that just encode various claims on it. George offers a thought experiment to test if something is wealth: if you produce a pile of gold, fish, or Lego bricks, you've clearly increased the amount of wealth in the world. But if you produce a giant pile of IOUs that just records who owns what and who owes what to whom, it doesn't matter how many of them you pile up or how long the chains of ownership get, you still haven't increased the amount of real wealth in the world. Again, this isn't saying the IOUs aren't valuable, they are. But they're only valuable because they ultimately point to real wealth. If you magically transported everyone over to a hypothetical Earth 2, carrying over all of Earth 1's money and financial instruments but none of Earth 1's tangible wealth, the value of all those IOUs would instantly evaporate. Now what about digital goods? Leaving things like Bitcoin aside for the moment, let's consider the case of a digital image file: By George, this is wealth. Digital though it may be, it's physically encoded on a storage device somewhere, and is thus tangible (it's not a pure abstract concept flitting about in Platonic heaven) and has its origins in nature. Human exertion built the computer that encodes it, and clicking the button that saves it to disk or displays it on your screen is labor. Finally, it directly satisfies human desires (mine, at the very least). It's value may be negligible, but it's wealth. By contrast, the digital bit sitting in some database that says I own a particular eBook or mp3 is just a digital IOU – a claim on the wealth that are the physical bits on my local storage device or remote server that digitally encodes the files. The fact that digital files don't seem particularly physical, and that they can be trivially and endlessly copied, doesn't mean that Henry George, magically transported to today, wouldn't regard them as wealth. Okay, so is there anything else that's not wealth? By George, Bitcoin isn't wealth, in case you were wondering. It's just a (very fancy) financial instrument, a digital claim on wealth. And that goes for most crypto assets – a token on some blockchain that says I own a painting by Banksy is just another IOU, regardless of the technical sophistication of its distributed trustless ledger. What about intellectual property? Copyrights, patents, and trademarks are all different forms of Monopoly – the exclusive, government-granted legal right to do a particular thing (publish a certain book, manufacture a certain product, use a certain name in business, etc). The exclusive right to do or produce a thing, valuable as it may be, is not the thing itself. By George, Monopoly is not wealth. But there is something big that is wealth – the C-word. Capital. By George, Capital is "wealth devoted to procuring more wealth", and it's the next thing he insists everyone is hopelessly confused about. He quotes Adam Smith, agreeing with him thus far: That part of a man's stock which he expects to afford him revenue is called his capital. ...and also gives us a short etymology lesson on the origin of the term: The word capital, as philologists trace it, comes down to us from a time when wealth was estimated in cattle, and a man's income depended upon the number of head he could keep for their increase. ("Per capita" being the Latin for "by head") By George, all capital is wealth, but not all wealth is capital. George notes capital is often described as being "stored up labor", and endorses this view – but what it really means, is capital is stored up production. It's not literally the labor that's stored up but the wealth generated by it, set aside and then dedicated to the purpose of getting more wealth. George insists that it is the owner's intention that transforms wealth into capital. If you buy an old factory to throw parties in for your hipster friends, it's just wealth. But the minute you decide to put it to work to make something useful (or start charging your hipster friends a cover charge at the door), it becomes capital. George therefore further insists that a laborer's daily bread and the clothes on their back do not count as capital, because a person has to eat and wear clothes whether they work or not. The laborer's tools (and arguably their steel-toed work boots) can however be counted as capital, because their purpose is to assist the laborer in getting more wealth by working for wages, and the laborer wouldn't acquire, use, and maintain those things otherwise. George has more exclusions: We must exclude from the category of capital everything that may be included either as land or labor. Human exertion (labor) by itself can never be capital. The products of human labor become capital when they are stored up and set to the purpose of getting more wealth. To muddle this distinction defeats the point of having separate terms for those things at all, and prevents us from reasoning meaningfully about how they relate to one another. Labor is not capital, and neither is labor by itself wealth, it produces wealth – and if it ain't wealth, it ain't capital. And that brings us to land. Land, land, land. By George, land is not wealth. And it's definitely not capital. The unique specialness of land is George's entire schtick and the very core of his philosophy. The term land embraces, in short, all natural materials, forces, and opportunities That means that a field or a meadow is "land", as is a mountain. But so are the fish in the sea, the clouds in the sky, veins of gold in the earth's crust, and the oil deep under ground. These things aren't yet wealth – not until human beings both a) desire them and b) touch them with labor. So... land is not wealth. But... how come? I mean, look: land is tangible, it "comes from nature", humans are always productively applying their labor to it, and it certainly seems capable of gratifying human desires. George sees this reasoning as understandable, but insists it's the root mistake that leads other political economists astray – because for George, land just is nature itself. Come again? Land is the ultimate source of all wealth, but it's most useful to think of it as a generator, acompletely separate entity from the wealth that human labor and desire draws from it. Players of Magic: the Gathering and Settlers of Catan should already have a solid grasp of this distinction: In modern times, George would grant electromagnetic spectrum and orbital real estate for satellites the same status of "land" that already applies to farmland and terrestrial real estate. We don't even need to speculate about whether he'd attach this status to sunlight because he straight-up predicted solar power: Even the lack of rain which makes some parts of the globe useless to man, may, if invention ever succeeds in directly utilizing the power of the sun's rays, be found to be especially advantageous for certain parts of production. (That's from Protection or Free Trade, footnote 19) The important thing to grasp about land is that it comes before everything humans do or make, and is itself a thing no human can make. Okay, smarty-pants, what about the Netherlands? They've been making land for centuries! Well, land in the Georgist sense doesn't refer simply to "dry land", but also the sea bed, the oceans, and the skies above. The "new land" in the Netherlands counts as an improvement to land that already existed. The seabed was always there, but by filling it in so you can walk around on it, now it's more useful to us (George has a lot to say about improvements to land, which we'll get to later). Okay, what is land not? nothing that is freely supplied by nature can be properly classed as capital By George, land is not wealth. And since it's not wealth, it's not capital. Okay, we get it. Land is very special to Mr. George and we must never put it in the same category as wealth, labor, capital, wages, production, money, or anything else. Why exactly is this so damn important? Well, by George, if you treat land the same way you would a bar of pig iron, an hour of work, or a dollar bill, before you know it you'll get poverty paradoxically advancing alongside progress, inexplicable bouts of industrial depression, literal genocides and holocausts (he's dead serious about this), and The Rent Being Too Damn High. With terminology now firmly established, George moves on to the relationship between wages and capital. 3-for-1 special on Wages, Capital, and Labor I'm condensing three chapters here because they all deal with the same basic thing. The question George wants to answer is: Why, in spite of increase in productive power, do wages tend to a minimum which will give but a bare living? The conventional wisdom of George's time is that wages are governed by a fixed ratio between the number of laborers and the amount of capital devoted to their employment, because "the increase in the number of laborers tends naturally to follow and overtake any increase in capital." So it doesn't matter how much capital you throw at employing workers, it'll just attract even more workers splitting it up, so although wages might temporarily wiggle a bit in the long term they'll always settle back to a "natural" minimum. (As we'll see in the next section, this argument stems from Malthusianism). George spends some time methodically poking holes in the theory (it's predictions don't line up with the facts he observes), and then sets out to prove his replacement theory (emphases mine): wages, instead of being drawn from capital, are in reality drawn from the product of the labor for which they are paid. He pulls a G.K. Chesterton to make his point: During the time [the laborer] is earning the wages he is advancing capital to his employer, but at no time, unless wages are paid before work is done, is the employer advancing capital to him. He starts by identifying the source of confusion: Because wages are generally paid in money, and in many of the operations of production are paid before the product is fully completed, or can be utilized, it is inferred that wages are drawn from pre-existing capital I mean, the old theory seems sensible: the employer has capital and uses it to pay wages. But however you slice it, capital's investment gets paid back by production when it takes its cut, so does it even make a difference to talk about where wages are "drawn" from? Value goes out, value comes in, isn't it all a wash? By George, it isn't: in the old theory, because capital "must come first", it follows that "industry is limited by capital - that capital must be accumulated before labor is employed", which leads to a reductio ad absurdum – We are told that capital is stored-up or accumulated labor – "that part of wealth which is saved to assist future production." If we substitute for the word "capital" this definition of the word, the proposition carries its own refutation, for that labor cannot be employed until the results of labor are saved becomes too absurd for discussion. George anticipates the following rejoinder – Well, when we say 'labor is paid out of capital' we don't mean it as an absolute statement for all stages of human development (or else we have a chicken-and-the-egg problem and civilization could never have begun), we just mean it applies to, say, every civilization that's left the stone age. George will have none of it and spends three entire chapters relentlessly beating to death the idea that wages are drawn from capital instead of from production. He starts with the simple case where wages are paid in the form of direct, concrete wealth, then moves on to the more complex case where people are paid in money and other instruments. Laboring for wages: Imagine a fishing village where nobody cooperates – each person digs their own bait and catches their own fish. Then they discover labor specialization and realize they can catch more fish together if one specializes in digging and the other in catching. So the digger digs, the catcher catches, and they share the fish. The digger really contributes as much to the catch as the one who physically pulls the fish off the hook even though the digger never directly "caught" a fish, and the fish he gets for his work is directly paid out of his contribution to the total production. Later, our fisherfolk invent canoes, and one stays home making and repairing canoes. This increases the haul of the digger and catcher, and the canoe-er gets paid out of her contribution to the increased production. And so it goes as society continues to advance. The work the specialist puts in causes more fish to be caught, and that person's wages is drawn from the growing pile of fish. As George puts it: "Earning is making." George gives another example: If I take a piece of leather and work it up into a pair of shoes, the shoes are my wages – the reward of my exertion. Surely they are not drawn from capital – either my capital or any one else's capital – but are brought into existence by the labor of which they become the wages; and in obtaining this pair of shoes as the wages of my labor, capital is not even momentarily lessened one iota... As my labor goes on, value is steadily added, until, when my labor results in the finished shoes, I have my capital plus the difference in value between the material and the shoes. And another: If I hire a man to gather eggs, to pick berries, or to make shoes, paying him from the eggs, the berries, or the shoes that his labor secures, there can be no question that the source of the wages is the labor for which they are paid. George goes on to say it doesn't matter if you're paid in money or directly in wealth, because the money is a direct claim on the underlying wealth. It also doesn't matter if you get paid on commission. Imagine a whaling ship where each crewman gets paid a share out of whatever the ship catches. When the ship sails back into port with a hold full of whale oil and bone, the crew gets paid in money, the owner simultaneously adds to his capital oil and bone. The crew's money directly represents their share of the concrete wealth that is the oil and bone. The owner's capital hasn't decreased, and the workers drew their wages directly from the production. So let's get to the point, Mr. George – wages aren't drawn from capital but instead from production. Great, let's grant that – so what? George hammers away at this because thinking wages are drawn from capital leads to a false conclusion, namely that "labor cannot exert its productive power unless supplied by capital with maintenance." "Maintenance?" Well, workers need food and clothing and they get paid by their employers, so you could imagine capital as a limiting factor on labor. But by George, food and clothing isn't capital, it's just wealth, as we said before. And with regard to wages, the point is that the employer always gets "paid" first, because the second the laborer produces value, the employer's capital increases: As in the exchange of labor for wages the employer always gets the capital created by the labor before he pays out capital in the wages, at what point is his capital lessened even temporarily? Okay, but what if I'm just a terrible businessman and I pay somebody $500 an hour to smash Ming vases, then sell the fragments as aggregate to a construction crew for a few pennies a pound, all at a tremendous loss? Surely then the laborer's wages must be drawn from my capital, because there's not enough productive value generated by the labor to draw them from! George says okay, sure, but only because I'm an idiot and will soon be out of business: Yet, unless the new value created by the labor is less than the wages paid, which can be only an exceptional case, the capital which he had before in money he now has in goods – it has been changed in form, but not lessened. Fair enough, Mr. George, but what if I'm building some enormously expensive multi-decade project, like a dam or a nuclear power plant or a cathedral? The kind of thing we call a "capital-intensive" project? What do you have to say to that? George points out that as laborers labor, they progressively add value to whatever they're producing. Take the case of a shipwright building ships for an employer – even if the boss can't sell a half-finished ship, it still holds value (for one, it costs less to finish a half-finished ship then no ship at all). And with every stroke of the laborer's work, the employer who owns the shipyard gets an incremental increase in his stock of capital. It is not the last blow, any more than the first blow, that creates the value of the finished product – the creation of value is continuous, it immediately results from the exertion of labor. A pedant would point out that the "last hit" that finishes the product which makes it ready for market adds disproportionate value, but George's point is just to establish that value is continuously created, and doesn't magically come into being allat once right at the end. George further points out that if you look at things like agriculture you'll see the market directly acknowledging his theory: As a plowed field will bring more than an unplowed field, or a field that has been sown more than one merely plowed... It is tangible in the case of orchards and vineyards which, though not yet in bearing, bring prices proportionate to their age. George freely admits that capital can be required for certain kinds of work, but he disagrees with what its purpose is. It's not a pool that wages get paid out of. He goes on for another chapter on "The Maintenance of Laborers Not Drawn From Capital" but I think we can safely skip it and move on. TL:DR – George hammers to absolute death the idea that Laborers derive their own maintenance (food/shelter/clothing/etc) from their wages, with George insisting it is drawn from production and... you guessed it, not from capital. At least some of George's ideas will not seem so radical to modern readers (especially those already critical of capitalism or neoclassical economics), but it's important to understand that at the time almost everything he was saying was considered deeply radical and shocking. Capital was the fundamental driving force of the economy and labor was utterly dependent on it, and the Malthusian theory of overpopulation was the accepted explanation for why wages were low and workers were starving. Political Cartoon literally demonizing Henry George – Puck magazine Oct. 20, 1886 The Real Functions of Capital Okay, Mr. George. You've spent three whole chapters beating me over the head with what the functions of capital aren't. So what are the functions of capital? Capital "increases the power of labor to produce wealth." How? By enabling labor to apply itself more effectively (power tools go brrrr)
Inline links: Political Economy, Economics, Georgism or Geoism, Paul Krugman, Milton Friedman, Friedrich Hayek, wasn't a fan, Nate Blair, BlueRepublik, Long Depression, source, https://substackcdn.com/image/fetch/$s_!L1cp!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F46a9ea6a-75a2-48cf-b2a5-368a5d450f4e_700x508.png, https://substackcdn.com/image/fetch/$s_!PHaw!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F4575c4fc-b789-4177-9c22-6bd6040ea5ba_726x512.png, extreme poverty has been going down everywhere, https://substackcdn.com/image/fetch/$s_!nnef!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F1115a295-9275-428a-8434-9572119c596d_3000x2100.png, source, Considerations on Cost Disease, https://substackcdn.com/image/fetch/$s_!UAJH!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F89ecab7d-431a-47c8-bcce-f5726db1a770_1600x1490.png, source, https://substackcdn.com/image/fetch/$s_!ndzi!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2Fbe29b221-a8f8-419d-8569-da46285e32ac_802x568.png, source, https://substackcdn.com/image/fetch/$s_!eyAX!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2Ff9b8eea9-8bd6-4c81-8dd7-93f192a542f7_980x713.png, source, https://substackcdn.com/image/fetch/$s_!80d0!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F1452e66e-c8f4-4174-92f7-31829f8cbd39_958x696.png, absolutely banana pants insane, Number of Homeless Children in U.S. At All-Time High; California Among Worst States, Labor Theory of Value, marginal revolution, blog, https://substackcdn.com/image/fetch/$s_!szbX!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F02e3f9db-5fe4-4a1b-bd19-5a13bac84aa1_500x500.png, https://substackcdn.com/image/fetch/$s_!cDFG!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F28ef979e-83da-4d1b-8d81-5f08fd6103a5_516x600.png, https://substackcdn.com/image/fetch/$s_!PVE6!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F68f4f7f0-2016-4fe9-9996-879a3c92db74_516x600.png, Protection or Free Trade, https://substackcdn.com/image/fetch/$s_!aeD5!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F348d4d74-8c98-42e6-b5f7-7bd79b30a816_960x611.png
Although 2021 seems better than 1879 in absolute material terms, George's complaint still rings true: healthcare and higher education are increasingly unaffordable, inequality is as bad as it ever was, and The Rent Is Too Damn High. And even if all of these measures had improved as well, we still have to contend with a fundamental complaint: how can human civilization have piled up an amount of wealth best described as absolutely banana pants insane, and yetstill have poverty, oppression and cyclical recessions? Yes, greed, evil, and human nature will always be with us, but isn't it weird that we haven't eliminated these economic problems the same way we've eliminated Smallpox, Scurvy, and having to write your scathing polemics about Thomas Jefferson by candlelight with a goose feather? Giving the mic back to George, he closes the chapter with this haunting quote, first written 142 years ago: If there is less deep poverty in San Fran Francisco than in New York, is it not because San Francisco is yet behind new York in all that both cities are striving for? When San Francisco reaches the point where New York now is, who can doubt that there will also be ragged and barefooted children on her streets? I'll just leave this here: Number of Homeless Children in U.S. At All-Time High; California Among Worst States. I. Wages and Capital George insists sloppy terminology leads to sloppy thinking. Naturally, he spends an entire chapter beating words to death to correct this. The Meaning of the Terms Let's start with Wealth. The common usage, both then and now, is "anything with an exchange value." George doesn't like how this mixes dissimilar things. By George, what is wealth? Wealth is produced when Nature's bounty is touched by human labor resulting in a tangible product that is the object of human desire. Labor is required, but the amount and type doesn't matter - George offers the example of simply picking a berry off a bush as an act that transforms nature's gifts into human wealth. Note particularly that human desire is an important requirement of wealth; it doesn't matter how much work someone put into something, if it doesn't gratify human needs or desires in some way, it's not wealth. Speaking of human desire, let's talk about Value. Where does a thing's value come from? The prevailing theory of the day was the Labor Theory of Value which originated with Adam Smith and David Ricardo, which says that Labor is the source of value. The early formulations were a bit ambiguous, here's Smith in Wealth of Nations for instance: The value of any commodity ... is equal to the quantity of labor which it enables him to purchase or command. Labor, therefore, is the real measure of the exchangeable value of all commodities. So... is a thing's value how much labor it takes to make the thing, or how much labor someone's willing to exchange for the thing? Nowadays Labor Theory of Value is most commonly associated with Marx. Marx picks a lane and says the value of something is tied to the amount of "socially necessary labor" required to produce it. George goes the other way: It is never the amount of labor that has been exerted in bringing a thing into being that determines its value, but always the amount of labor that will be rendered in exchange for it. - Henry George, The Science of Political Economy, p. 253 In other words, "a thing's value is whatever someone is willing to pay for it." This is in line with the so-called marginal revolution (the movement, not the blog) and modern theories of value. Labor Labor is the exertion of human beings. It's possible to labor to no avail (try punching a concrete wall), but typically humans labor towards an end, such as gaining wealth. But whether or not we accomplish anything with our efforts, George calls them labor. Labor isn't just making things, by the way – it's also moving or exchanging them. Production Production is labor applied "to the production of wealth." You know, productively. This is all human exertion that isn't punching a concrete wall and rewards you for your efforts with something that fits the definition of wealth. Said wealth is the "product of labor." Wages whatever is received as the result or reward of exertion is "wages." No distinction here is made between blue-collar work and white-collar work – whether one is called "hourly pay" and the other is called "annual salary," George calls them both "wages." It doesn't matter whether you receive them from your boss, from customers, or from nature. If you do work and get something from it, you have received "wages." With those basics under our belt, let's circle back to Wealth: What are some examples of wealth? By George, Gold is wealth. Teddy bears are wealth. Tesla roadsters and candy canes and young adult vampire romance novels are wealth. The same goes for fish you've caught, deer you've hunted, and cool looking rocks you've picked up on your morning walk. The value of these things may differ, but as long as they're tangible, originate in nature, someone ever did a lick of work to make or acquire them, and a human being somewhere desires them for any reason, they're wealth. It gets a little clearer when we ask what isn't wealth. And by George, Money isn't wealth. Articles of gold are wealth because they're tangible things that have been dug up, crafted, and fulfill certain human desires. But paper currency, digital currencies, and other things that aren't inherently valuable but merely represent value are not wealth (outside of putting their physical articles in coin collections or making paper airplanes, and so forth). Now don't get the man wrong, these things are certainly valuable. They're just not wealth. They are certificates that represent claims on wealth. For any computer programmers in the audience, money is a pointer to wealth. Likewise Stocks and Bonds and other financial instruments are not wealth. These are also just claims on wealth. A creditor's title to Debt isn't wealth, either, it's just a claim on the debtor's (typically future) wealth. And, writing as he was not long after the Civil War, George points out that Slaves are not wealth either but, represent "merely the power of one class to appropriate the earnings of another class." Wealth, thus defined, is the terminal "ground truth" bits of the economy, and all the financial layers on top are fancy IOUs that just encode various claims on it. George offers a thought experiment to test if something is wealth: if you produce a pile of gold, fish, or Lego bricks, you've clearly increased the amount of wealth in the world. But if you produce a giant pile of IOUs that just records who owns what and who owes what to whom, it doesn't matter how many of them you pile up or how long the chains of ownership get, you still haven't increased the amount of real wealth in the world. Again, this isn't saying the IOUs aren't valuable, they are. But they're only valuable because they ultimately point to real wealth. If you magically transported everyone over to a hypothetical Earth 2, carrying over all of Earth 1's money and financial instruments but none of Earth 1's tangible wealth, the value of all those IOUs would instantly evaporate. Now what about digital goods? Leaving things like Bitcoin aside for the moment, let's consider the case of a digital image file: By George, this is wealth. Digital though it may be, it's physically encoded on a storage device somewhere, and is thus tangible (it's not a pure abstract concept flitting about in Platonic heaven) and has its origins in nature. Human exertion built the computer that encodes it, and clicking the button that saves it to disk or displays it on your screen is labor. Finally, it directly satisfies human desires (mine, at the very least). It's value may be negligible, but it's wealth. By contrast, the digital bit sitting in some database that says I own a particular eBook or mp3 is just a digital IOU – a claim on the wealth that are the physical bits on my local storage device or remote server that digitally encodes the files. The fact that digital files don't seem particularly physical, and that they can be trivially and endlessly copied, doesn't mean that Henry George, magically transported to today, wouldn't regard them as wealth. Okay, so is there anything else that's not wealth? By George, Bitcoin isn't wealth, in case you were wondering. It's just a (very fancy) financial instrument, a digital claim on wealth. And that goes for most crypto assets – a token on some blockchain that says I own a painting by Banksy is just another IOU, regardless of the technical sophistication of its distributed trustless ledger. What about intellectual property? Copyrights, patents, and trademarks are all different forms of Monopoly – the exclusive, government-granted legal right to do a particular thing (publish a certain book, manufacture a certain product, use a certain name in business, etc). The exclusive right to do or produce a thing, valuable as it may be, is not the thing itself. By George, Monopoly is not wealth. But there is something big that is wealth – the C-word. Capital. By George, Capital is "wealth devoted to procuring more wealth", and it's the next thing he insists everyone is hopelessly confused about. He quotes Adam Smith, agreeing with him thus far: That part of a man's stock which he expects to afford him revenue is called his capital. ...and also gives us a short etymology lesson on the origin of the term: The word capital, as philologists trace it, comes down to us from a time when wealth was estimated in cattle, and a man's income depended upon the number of head he could keep for their increase. ("Per capita" being the Latin for "by head") By George, all capital is wealth, but not all wealth is capital. George notes capital is often described as being "stored up labor", and endorses this view – but what it really means, is capital is stored up production. It's not literally the labor that's stored up but the wealth generated by it, set aside and then dedicated to the purpose of getting more wealth. George insists that it is the owner's intention that transforms wealth into capital. If you buy an old factory to throw parties in for your hipster friends, it's just wealth. But the minute you decide to put it to work to make something useful (or start charging your hipster friends a cover charge at the door), it becomes capital. George therefore further insists that a laborer's daily bread and the clothes on their back do not count as capital, because a person has to eat and wear clothes whether they work or not. The laborer's tools (and arguably their steel-toed work boots) can however be counted as capital, because their purpose is to assist the laborer in getting more wealth by working for wages, and the laborer wouldn't acquire, use, and maintain those things otherwise. George has more exclusions: We must exclude from the category of capital everything that may be included either as land or labor. Human exertion (labor) by itself can never be capital. The products of human labor become capital when they are stored up and set to the purpose of getting more wealth. To muddle this distinction defeats the point of having separate terms for those things at all, and prevents us from reasoning meaningfully about how they relate to one another. Labor is not capital, and neither is labor by itself wealth, it produces wealth – and if it ain't wealth, it ain't capital. And that brings us to land. Land, land, land. By George, land is not wealth. And it's definitely not capital. The unique specialness of land is George's entire schtick and the very core of his philosophy. The term land embraces, in short, all natural materials, forces, and opportunities That means that a field or a meadow is "land", as is a mountain. But so are the fish in the sea, the clouds in the sky, veins of gold in the earth's crust, and the oil deep under ground. These things aren't yet wealth – not until human beings both a) desire them and b) touch them with labor. So... land is not wealth. But... how come? I mean, look: land is tangible, it "comes from nature", humans are always productively applying their labor to it, and it certainly seems capable of gratifying human desires. George sees this reasoning as understandable, but insists it's the root mistake that leads other political economists astray – because for George, land just is nature itself. Come again? Land is the ultimate source of all wealth, but it's most useful to think of it as a generator, acompletely separate entity from the wealth that human labor and desire draws from it. Players of Magic: the Gathering and Settlers of Catan should already have a solid grasp of this distinction: In modern times, George would grant electromagnetic spectrum and orbital real estate for satellites the same status of "land" that already applies to farmland and terrestrial real estate. We don't even need to speculate about whether he'd attach this status to sunlight because he straight-up predicted solar power: Even the lack of rain which makes some parts of the globe useless to man, may, if invention ever succeeds in directly utilizing the power of the sun's rays, be found to be especially advantageous for certain parts of production. (That's from Protection or Free Trade, footnote 19) The important thing to grasp about land is that it comes before everything humans do or make, and is itself a thing no human can make. Okay, smarty-pants, what about the Netherlands? They've been making land for centuries! Well, land in the Georgist sense doesn't refer simply to "dry land", but also the sea bed, the oceans, and the skies above. The "new land" in the Netherlands counts as an improvement to land that already existed. The seabed was always there, but by filling it in so you can walk around on it, now it's more useful to us (George has a lot to say about improvements to land, which we'll get to later). Okay, what is land not? nothing that is freely supplied by nature can be properly classed as capital By George, land is not wealth. And since it's not wealth, it's not capital. Okay, we get it. Land is very special to Mr. George and we must never put it in the same category as wealth, labor, capital, wages, production, money, or anything else. Why exactly is this so damn important? Well, by George, if you treat land the same way you would a bar of pig iron, an hour of work, or a dollar bill, before you know it you'll get poverty paradoxically advancing alongside progress, inexplicable bouts of industrial depression, literal genocides and holocausts (he's dead serious about this), and The Rent Being Too Damn High. With terminology now firmly established, George moves on to the relationship between wages and capital. 3-for-1 special on Wages, Capital, and Labor I'm condensing three chapters here because they all deal with the same basic thing. The question George wants to answer is: Why, in spite of increase in productive power, do wages tend to a minimum which will give but a bare living? The conventional wisdom of George's time is that wages are governed by a fixed ratio between the number of laborers and the amount of capital devoted to their employment, because "the increase in the number of laborers tends naturally to follow and overtake any increase in capital." So it doesn't matter how much capital you throw at employing workers, it'll just attract even more workers splitting it up, so although wages might temporarily wiggle a bit in the long term they'll always settle back to a "natural" minimum. (As we'll see in the next section, this argument stems from Malthusianism). George spends some time methodically poking holes in the theory (it's predictions don't line up with the facts he observes), and then sets out to prove his replacement theory (emphases mine): wages, instead of being drawn from capital, are in reality drawn from the product of the labor for which they are paid. He pulls a G.K. Chesterton to make his point: During the time [the laborer] is earning the wages he is advancing capital to his employer, but at no time, unless wages are paid before work is done, is the employer advancing capital to him. He starts by identifying the source of confusion: Because wages are generally paid in money, and in many of the operations of production are paid before the product is fully completed, or can be utilized, it is inferred that wages are drawn from pre-existing capital I mean, the old theory seems sensible: the employer has capital and uses it to pay wages. But however you slice it, capital's investment gets paid back by production when it takes its cut, so does it even make a difference to talk about where wages are "drawn" from? Value goes out, value comes in, isn't it all a wash? By George, it isn't: in the old theory, because capital "must come first", it follows that "industry is limited by capital - that capital must be accumulated before labor is employed", which leads to a reductio ad absurdum – We are told that capital is stored-up or accumulated labor – "that part of wealth which is saved to assist future production." If we substitute for the word "capital" this definition of the word, the proposition carries its own refutation, for that labor cannot be employed until the results of labor are saved becomes too absurd for discussion. George anticipates the following rejoinder – Well, when we say 'labor is paid out of capital' we don't mean it as an absolute statement for all stages of human development (or else we have a chicken-and-the-egg problem and civilization could never have begun), we just mean it applies to, say, every civilization that's left the stone age. George will have none of it and spends three entire chapters relentlessly beating to death the idea that wages are drawn from capital instead of from production. He starts with the simple case where wages are paid in the form of direct, concrete wealth, then moves on to the more complex case where people are paid in money and other instruments. Laboring for wages: Imagine a fishing village where nobody cooperates – each person digs their own bait and catches their own fish. Then they discover labor specialization and realize they can catch more fish together if one specializes in digging and the other in catching. So the digger digs, the catcher catches, and they share the fish. The digger really contributes as much to the catch as the one who physically pulls the fish off the hook even though the digger never directly "caught" a fish, and the fish he gets for his work is directly paid out of his contribution to the total production. Later, our fisherfolk invent canoes, and one stays home making and repairing canoes. This increases the haul of the digger and catcher, and the canoe-er gets paid out of her contribution to the increased production. And so it goes as society continues to advance. The work the specialist puts in causes more fish to be caught, and that person's wages is drawn from the growing pile of fish. As George puts it: "Earning is making." George gives another example: If I take a piece of leather and work it up into a pair of shoes, the shoes are my wages – the reward of my exertion. Surely they are not drawn from capital – either my capital or any one else's capital – but are brought into existence by the labor of which they become the wages; and in obtaining this pair of shoes as the wages of my labor, capital is not even momentarily lessened one iota... As my labor goes on, value is steadily added, until, when my labor results in the finished shoes, I have my capital plus the difference in value between the material and the shoes. And another: If I hire a man to gather eggs, to pick berries, or to make shoes, paying him from the eggs, the berries, or the shoes that his labor secures, there can be no question that the source of the wages is the labor for which they are paid. George goes on to say it doesn't matter if you're paid in money or directly in wealth, because the money is a direct claim on the underlying wealth. It also doesn't matter if you get paid on commission. Imagine a whaling ship where each crewman gets paid a share out of whatever the ship catches. When the ship sails back into port with a hold full of whale oil and bone, the crew gets paid in money, the owner simultaneously adds to his capital oil and bone. The crew's money directly represents their share of the concrete wealth that is the oil and bone. The owner's capital hasn't decreased, and the workers drew their wages directly from the production. So let's get to the point, Mr. George – wages aren't drawn from capital but instead from production. Great, let's grant that – so what? George hammers away at this because thinking wages are drawn from capital leads to a false conclusion, namely that "labor cannot exert its productive power unless supplied by capital with maintenance." "Maintenance?" Well, workers need food and clothing and they get paid by their employers, so you could imagine capital as a limiting factor on labor. But by George, food and clothing isn't capital, it's just wealth, as we said before. And with regard to wages, the point is that the employer always gets "paid" first, because the second the laborer produces value, the employer's capital increases: As in the exchange of labor for wages the employer always gets the capital created by the labor before he pays out capital in the wages, at what point is his capital lessened even temporarily? Okay, but what if I'm just a terrible businessman and I pay somebody $500 an hour to smash Ming vases, then sell the fragments as aggregate to a construction crew for a few pennies a pound, all at a tremendous loss? Surely then the laborer's wages must be drawn from my capital, because there's not enough productive value generated by the labor to draw them from! George says okay, sure, but only because I'm an idiot and will soon be out of business: Yet, unless the new value created by the labor is less than the wages paid, which can be only an exceptional case, the capital which he had before in money he now has in goods – it has been changed in form, but not lessened. Fair enough, Mr. George, but what if I'm building some enormously expensive multi-decade project, like a dam or a nuclear power plant or a cathedral? The kind of thing we call a "capital-intensive" project? What do you have to say to that? George points out that as laborers labor, they progressively add value to whatever they're producing. Take the case of a shipwright building ships for an employer – even if the boss can't sell a half-finished ship, it still holds value (for one, it costs less to finish a half-finished ship then no ship at all). And with every stroke of the laborer's work, the employer who owns the shipyard gets an incremental increase in his stock of capital. It is not the last blow, any more than the first blow, that creates the value of the finished product – the creation of value is continuous, it immediately results from the exertion of labor. A pedant would point out that the "last hit" that finishes the product which makes it ready for market adds disproportionate value, but George's point is just to establish that value is continuously created, and doesn't magically come into being allat once right at the end. George further points out that if you look at things like agriculture you'll see the market directly acknowledging his theory: As a plowed field will bring more than an unplowed field, or a field that has been sown more than one merely plowed... It is tangible in the case of orchards and vineyards which, though not yet in bearing, bring prices proportionate to their age. George freely admits that capital can be required for certain kinds of work, but he disagrees with what its purpose is. It's not a pool that wages get paid out of. He goes on for another chapter on "The Maintenance of Laborers Not Drawn From Capital" but I think we can safely skip it and move on. TL:DR – George hammers to absolute death the idea that Laborers derive their own maintenance (food/shelter/clothing/etc) from their wages, with George insisting it is drawn from production and... you guessed it, not from capital. At least some of George's ideas will not seem so radical to modern readers (especially those already critical of capitalism or neoclassical economics), but it's important to understand that at the time almost everything he was saying was considered deeply radical and shocking. Capital was the fundamental driving force of the economy and labor was utterly dependent on it, and the Malthusian theory of overpopulation was the accepted explanation for why wages were low and workers were starving. Political Cartoon literally demonizing Henry George – Puck magazine Oct. 20, 1886 The Real Functions of Capital Okay, Mr. George. You've spent three whole chapters beating me over the head with what the functions of capital aren't. So what are the functions of capital? Capital "increases the power of labor to produce wealth." How? By enabling labor to apply itself more effectively (power tools go brrrr)
Inline links: absolutely banana pants insane, Number of Homeless Children in U.S. At All-Time High; California Among Worst States, Labor Theory of Value, marginal revolution, blog, https://substackcdn.com/image/fetch/$s_!szbX!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F02e3f9db-5fe4-4a1b-bd19-5a13bac84aa1_500x500.png, https://substackcdn.com/image/fetch/$s_!cDFG!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F28ef979e-83da-4d1b-8d81-5f08fd6103a5_516x600.png, https://substackcdn.com/image/fetch/$s_!PVE6!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F68f4f7f0-2016-4fe9-9996-879a3c92db74_516x600.png, Protection or Free Trade, https://substackcdn.com/image/fetch/$s_!aeD5!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F348d4d74-8c98-42e6-b5f7-7bd79b30a816_960x611.png
By making possible the division & specialization of labor (you dig bait, I'll catch fish) Capital is a force multiplier that supercharges the productive power of labor. It doesn't supply labor with raw materials (nature does), nor does it provide for the maintenance of workers (who eat bread by the sweat of their own brow). George says this is why capital isn't a limit on industry. ...okay, George grants that capital may limit the form of industry. You can't plow without a plow or milk without a cow. George also grants that the lack of specialized tools can greatly limit productivity because you don't get the benefit of the force-multiplying effect of capital. Um... aren't you contradicting yourself here, Mr. George? You spent all this time hammering home your doctrine of wages to prove that capital doesn't limit industry, but you just said its absence can limit both the form and the productivity of labor! Time to unpack what we mean by "limit" and be super clear about it from now on: But to say that capital may limit the form of industry or the productiveness of industry is a very different thing from saying that capital limits industry. Okay, what do you mean? For the dictum of the current political economy that "capital limits industry," means not that capital limits the form of labor or the productiveness of labor, but that it limits the exertion of labor. Okay, I think I see what he's saying. The existing school of thought says that because capital provides labor with both materials and maintenance, therefore if capital dries up, labor productivity must go down because workers will have nothing to work on, and nothing to eat or wear. Labor is thus "limited" by capital, for without it is literally and metaphorically starved for capital. But George says no – the only way capital actually "limits" productivity in real life is in the degrees by which it force-multiplies labor's productivity and unlocks certain forms of labor in the tech tree. The kind of "limit" George objects to is the idea that you need capital just to get any work done at all, or that without capital to sustain it, labor will shrivel up. Instead, capital is rocket fuel that labor supplies to itself by investing a portion of its wages. And yet, with all the awesome slots we've unlocked on the tech tree, and barrels and barrels of rocket fuel to fire up eager laborers, we still find our economy sinking into mysterious depressions. Something is gumming up the works, but it's not a simple scarcity of capital: the real limitation is not the want of capital, but the want of its proper distribution Or as G.K. Chesterton said, "Too much capitalism does not mean too many capitalists, but too few capitalists." This might seem like a pedantic distinction – misallocated capital could be said to be "scarce" capital – but they're not the same thing at all. As Francis Bacon said in 1625: Riches were like [Manure]: When it lay, upon an heape, it gave but a stench, and ill odour; but when it was spread upon the ground, then it was cause of much fruit. Because the prevailing theories of George's time are based on incorrect ideas about the relation between wages and capital, "all remedies, whether proposed by professors of political economy or workingmen, which look to the alleviation of poverty either by the increase of capital or the restriction of the number of laborers or the efficiency of their work, must be condemned." In short, more investment, more protectionism, and more efficiency programs can't, won't, and haven't fixed poverty and industrial depressions because they all proceed from false premises. Having finally beaten the nexus of wages, capital, and labor into a bloody pulp, George turns his eyes towards another leading theory for why everything is terrible: the specter of overpopulation. II. Population and Subsistence The entire second book might as well be titled "Why Malthus is Dumb and Wrong and Bad." It's dedicated to dunking on Malthusianism, a philosophy that ascribes economic crises to the exponential growth of the human population, which must necessarily end in catastrophe. according to Malthusian theory, poverty appears as increase in population necessitates the more minute division of subsistence. George attacks Malthusian ideas not just because they're wrong, but because they make it easier to accept the prevailing theory of wages (as more capital is allocated, laborers will keep popping up like weeds to gobble it up, so wages must eternally stagnate). George draws a straight line between these faulty ideas and holocausts and genocides – specifically citing how colonial oppression in China, India, and Ireland were explicitly justified on Malthusian grounds. One million people died in the English-engineered Irish potato famine alone, and when you add in those who fled the entire population declined by 25% percent. And this isn't a tenuous link either – George directly connects the completely avoidable famine to his favorite bugbear, private landownership and extortionate rent. Given that Malthusianism is now widely discredited I'm just going to skip this chapter, but if you want to hear George in all his righteous fury, check out Appendix A (there's a link that returns here at the end): Appendix A: George Dunks on Malthusianism III. The Laws of Distribution When society produces wealth, who gets different shares of it, and why? Let's start by beating some words to death. By George, we're told that there are three factors in production: Land, Labor, and Capital. For each of these terms there must be a "law of distribution" that explains how each gets compensated for its part in production. The reward you get from production by owning Land is called Rent. The reward you get from production by supplying Labor is called Wages. The reward you get from production by supplying Capital is called ... um, what? We're looking for a term that clearly expresses the return to capital alone and nothing else. The closest thing we have is Interest, and that's probably good enough. George gives the common definition of interest as "the return for the use of capital, exclusive of any labor in its use or management, and exclusive of any risk, except such as may be involved in the security." This is pretty close to what we want – something that expresses the sole return to capital without mixing in anything else. But ... what about Profits? Profits is "almost synonymous" with revenue, assuming you have some left after you deduct expenses. It means a gain in money or wealth, but the trouble is this gain is a mix of rent, wages, and "compensations for the risk peculiar to the various uses of capital." What we want is a term that means the return to capital alone, totally separate from the return to laborers and landowners. To talk about the distribution of wealth into rent, wages, and profits is like talking of the division of mankind into men, women, and human beings. George spends a few pages talking about how everyone from Adam Smith on down got confused about this (spoiler: it's tied up with thinking wages are drawn from capital), before presenting his model for how it all works. If you want to see him knock that stuff down, see Appendix B (there's a link that returns here at the end): Appendix B: George dunks on the Conventional Laws of Distribution Here's George's model for how it all works: Land is"all natural opportunities or forces" and its return is rent Labor is "all human exertion" and its return is wages Capital is"all wealth used to produce more wealth" and its return is interest George says the false assumption at the root of the old theories is in thinking of "capital as the prime factor in production, land as its instrument, and labor as its agent or tool." George makes the following assertions: "Labor can be exerted only upon land"
Inline links: Francis Bacon said in 1625, Malthusianism, English-engineered Irish potato famine, Appendix A: George Dunks on Malthusianism, Appendix B: George dunks on the Conventional Laws of Distribution
Political Philosophy1 mentions across 1 issues

Political Philosophy is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between March 24, 2022 and March 24, 2022. The archive places it in contexts such as "Young philosopher who teaches Political Phil here". It most often appears alongside 1984, Acrolectics, Adnamanil.

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Political Philosophy
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Highlights From The Comments On Justice Creep
March 24, 2022 · Original source
Young philosopher who teaches Political Phil here (though doesn’t publish, so not an expert).
Political Relater1 mentions across 1 issues

Political Relater is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between February 21, 2024 and February 21, 2024. The archive places it in contexts such as "switched to "Political Relater""; "I might say to my past self 'you don't dislike Political Relaters...'". It most often appears alongside 2017 SSC survey, A Woman First: First Woman: A Memoir, Aella.

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Political Relater
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Highlights From The Comments On Polyamory
February 21, 2024 · Original source
Reducing one's romantic relationships to political statements is a real thing. I spent time for a few years in a polyamory group which turned into a Relationship Anarchy group. They redefined "Polyamory" to mean every bad thing that anyone labeling themselves polyamorous had ever done to them. Some of them eventually did that to the term "Relationship Anarchist" too, and switched to "Political Relater". I wrote more about this here:
In retrospect, I might say to my past self "you don't dislike Political Relaters, you dislike those who attend meetups about things."
polyamorous people1 mentions across 1 issues

polyamorous people is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between May 11, 2023 and May 11, 2023. The archive places it in contexts such as "polyamorous people and rationalists did"; "There were a few exceptions - polyamorous people". It most often appears alongside 15th Commandment, ACX, ADHD.

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polyamorous people
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Highlights From The Comments On Long COVID And Bisexuality
May 11, 2023 · Original source
I checked to see if people who identified with other vague categories had more Long COVID. This was mostly true for left-leaning or weird categories, and mostly false for right-leaning or normal categories. For example, Christians and Republicans had no more Long COVID than people who said no religion or no political party, but polyamorous people and rationalists did. The strongest effect was for ambidextrous people, but ambidextrous people also have more mental illness.
There were a few exceptions - polyamorous people, rationalists, and (to a much lesser degree) effective altruists all had higher Long COVID too. But these groups also have higher rates of bisexuality and mental illness; I think they are just weird.
As we saw above, certain weird-identity havers like polyamorous people and rationalists did have more Long COVID, but I attributed that to being part of the same cluster of genuinely weird people as bisexuals.
polyamory community1 mentions across 1 issues

polyamory community is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between September 13, 2022 and September 13, 2022. The archive places it in contexts such as "my experiences with the polyamory community strongly confirm this". It most often appears alongside Andres, bereavement, companionate love.

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polyamory community
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Unpredictable Reward, Predictable Happiness
September 13, 2022 · Original source
Although I don’t always trust psych studies, my experiences with the polyamory community strongly confirm this. Poly people talk about “new relationship energy” - if you start a relationship with a new person, you will be passionately into them for a few months, usually at the expense of all your other relationships, before settling back down again. Most poly advice books will give you tips for managing it, which mostly boil down to for God’s sake, don’t take your feelings seriously and deprioritize all your other relationships because this new one is so much better.
Inline links: new relationship energy
Polyamory Theory1 mentions across 1 issues

Polyamory Theory is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between February 21, 2024 and February 21, 2024. The archive places it in contexts such as ""toxic people yell 'I'm polyamorous!' and, suddenly, the topic shifts away from the toxicity to defenses of Polyamory Theory"". It most often appears alongside 2017 SSC survey, A Woman First: First Woman: A Memoir, Aella.

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Polyamory Theory
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Highlights From The Comments On Polyamory
February 21, 2024 · Original source
1) Polyamorous 20-somethings. These guys are insufferable. They jump back and forth between "You shouldn't be so judgmental" and "Polyamory is the only ethical way to hold relationships". "You shouldn't snark at people who are different than you" and "The human heart is large enough to hold more than one person!" "LET ME TELL YOU ABOUT THE JOYS OF NRE!!!" Toxic people yell "I'm polyamorous!" and, suddenly, the topic shifts away from the toxicity to defenses of Polyamory Theory. Ryan cheats on Chris and the community joins together to tell Chris to be more open-minded and less selfish.
Polycentric governance1 mentions across 1 issues

Polycentric governance is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between August 02, 2021 and August 02, 2021. The archive places it in contexts such as "Mariposa's core values include: Polycentric governance". It most often appears alongside AgroAlpha, Alex Tabarrok, Amazon.

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Polycentric governance
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21
August 02, 2021 · Original source
Polycentric governance, seemingly inspired by cryptocurrency.
polycystic ovarian syndrome1 mentions across 1 issues

polycystic ovarian syndrome is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between July 31, 2025 and July 31, 2025. The archive places it in contexts such as "Women with polycystic ovarian syndrome (prevalence: 10%) may get as many as 20". It most often appears alongside 23andMe, 23andme, Alex Young.

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Suddenly, Trait-Based Embryo Selection
July 31, 2025 · Original source
Herasight’s numbers on how breast cancer risk goes down with number of embryos used in selection. A typical round of IVF produces 1-10 embryos (younger women usually = more). Women with polycystic ovarian syndrome (prevalence: 10%) may get as many as 20. For more, you will probably need to do multiple IVF rounds. Here is a table of different companies’ reported risk reductions, slightly adjusted7 for different reporting conventions but otherwise taking all claims at face value (we’ll talk about how wise that is later). Relative risk reduction for five conditions (gray = no data / disputed data). Here baseline is for embryos neither of whose parents have the condition. GP and Orchid both say their technology has improved since reporting these numbers and they will report better numbers soon. GP numbers are not within-family validated and might be lower if they were. Absolute risk after selection for five conditions (gray = no data / disputed data), ibid. Some people might genuinely want to select on a single condition. For example, people with a strong family history of schizophrenia might want to minimize the chance of their children getting the disease; for these people, reducing schizophrenia risk by 58% (while keeping everything else constant) sounds pretty good. Everyone else probably wants a generically healthy embryo with low risk of all conditions. Exactly how this works depends on the customer’s own values - would they prefer an embryo with lower cancer risk to one who will have fewer heart attacks? - and the exact benefits will depend on how parents make that decision. Genomic Prediction and Herasight try to help by providing semi-objective measures of which embryo is overall healthiest according to different conditions’ effects on longevity and patient-rated quality of life. For Genomic Prediction, that’s the “embryo health score” If you selected the single highest-health-score embryo from a set of five, here’s how they’d do: For Herasight, it’s a “polygenic longevity index”. They don’t give exact risk reduction numbers for each disease, saying that it depends too much on a couple’s specific family history, but say that most people gain 1-4 years of healthy life (when I test it on a set of twenty embryos, the the healthiest gets an extra 1.66 years). How much would you pay to give your children an extra 1-4 years of healthy life? This is no longer a hypothetical question. Here are the costs of the companies in this space: Is it worth it? If: You’re already doing IVF
Inline links: 7, https://substackcdn.com/image/fetch/$s_!0oUh!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fe8419603-9239-43bb-8c79-77b078ff0789_548x136.png, https://substackcdn.com/image/fetch/$s_!rpEJ!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fc539a717-a130-460d-90c9-4ab64619f26d_548x133.png, https://substackcdn.com/image/fetch/$s_!3Kc6!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fbda325bb-13fb-4c27-b8c3-24facce5c71a_676x153.png, https://substackcdn.com/image/fetch/$s_!t1Am!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F831ab3c6-4053-4ff9-bc2f-879aee4349cf_673x740.png, https://substackcdn.com/image/fetch/$s_!Q2vE!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fadcf2bb4-8dd1-4a88-9728-6953a820971b_422x575.png
polyelectrolyte1 mentions across 1 issues

polyelectrolyte is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between June 18, 2025 and June 18, 2025. The archive places it in contexts such as "testing polyelectrolyte (PE) coatings on 24nm pore membranes featuring a negative terminal charge". It most often appears alongside 1DaySooner, Aatu Koskensilta, acanthamoeba keratitis.

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polyelectrolyte
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1
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June 18, 2025
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June 18, 2025
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ACX Grants 1-3 Year Updates
June 18, 2025 · Original source
Minnesota and Virginia also have legislation to enable cities to implement land value taxes. We are monitoring these efforts. There are a few other cities we are operating in. We have helped another organization prepare for a meeting in Tennessee by doing impact analysis of land value taxes in the city. We have presented to city officials in the City of South Bend who have expressed support for land value taxes. Finally, we are in conversation with a State Senator in Colorado who is a champion of land value taxes. Meanwhile, we have soft launched and developed the OpenAVMKit, which uses a unified schema to do assessment accuracy reports and automated valuation methods for any property tax data given. Valuation of land is the key binding constraint to successful implementation of land value taxes. We plan to be the leaders in this space with strong benchmarking capabilities and a repo that can enable the open-source community to make the best automated valuation methods. Along with these efforts, we have expanded the movement. We have posted to the Progress and Poverty Substack growing the subscriber base to around 5,000 subscribers. We have spoken to over 25 local advocates interested in working on land value taxes in their local communities. Yet, there is a long way to go. We need to start earning income through technical assistance contracts as our grant funding expires. We need to continue pushing for a state to implement, and we need to be prepared to tell the success story for when they do. 65: EN’s Work On Bacteriophage Therapy Our project is aimed at pioneering phage therapy in Nigeria, where limited resources/infrastructure have historically held back research in this field. Starting from the ground up, we are establishing the foundational systems needed to support a robust phage research ecosystem. So far, we’ve isolated 34 bacteriophages targeting Pseudomonas aeruginosa, an essential step toward building a comprehensive phage bank. This began with collecting a wide range of clinical Pseudomonas isolates, which we are now characterizing alongside the phages through genome sequencing and phenotypic assays including studies on phage stability across pH, temperature, and salinity ranges. Our long-term goal is to develop a phage-based hydrogel for treating diabetic wounds. On the regulatory front, we have secured approval from the Attorney General to register our nonprofit organization, the Centre for Phage Biology and Therapeutics. Additionally, we’re expanding into vaccine development; following a research stay in Prof. Roderick's lab at the University of Waterloo, we have initiated the design of a phage-based universal Salmonella vaccine aimed at covering all major serotypes—an urgent need underscored by Africa’s reliance on external vaccine sources during the COVID-19 pandemic. I have signed an MTA agreement with Roderick to use his phage-based vaccine platform patents to enable us to design vaccines against any common disease affecting us. This is only the beginning, but we are proud to be laying the scientific and institutional groundwork for homegrown phage innovation in Africa. Emergent Ventures funded EN before we did and deserves a lot of credit here also. 66: Create An Artificial Kidney For an implantable artificial kidney, the first essential component is a hemofilter designed to emulate the glomerulus. Critical requirements for this hemofilter include high permeability (to maximize flow for a given area), selectivity (specifically, the retention of albumin), and robust blood compatibility (ensuring sustained function over time). Our initial strategy focused on using negative surface charge to reduce fouling. I began by testing polyelectrolyte (PE) coatings on 24nm pore membranes featuring a negative terminal charge, similar to the glomerular barrier. These initial static tests, assessing platelet adsorption in whole blood, yielded positive outcomes for some polyelectrolytes, indicating potentially desirable blood compatibility. However, static test setups are not truly representative of dynamic in-vitro conditions and don't provide data on key parameters like permeability, fouling progression, or changes in membrane selectivity. To address these limitations, I designed and built a blood filtration setup. This system sustains human whole blood in circulation for 20 minutes, allowing us to analyze all the aforementioned parameters, as well as platelet activation markers. This has resulted in a fairly high-throughput system for evaluating any surface coating. I'm pleased to report this setup has been accepted for presentation at this year's European Society for Artificial Organs (ESAIO) conference. I am also currently working on a full manuscript, as I believe this system offers a viable way to partially replace animal experiments in our early-stage research, requiring only 1.2ml of human blood per run. Working with a PhD student (hired to support both this research and work on membrane substrates), we have continued testing these PE coatings, alongside PEG coatings, on our membranes. Here, we're finding that optimization of the coating layer is crucial. With the current PE coatings, we observe a permeability drop of about an order of magnitude compared to the base membrane, making them unsuitable for an implantable device in their present form. This is likely due to the specific nature of the initial PE layer, which we can modify. We also suspect there may be ingress of PE into the pores, meaning we're not achieving just a surface coating (our goal), but rather a very thick coating, which would explain the flux loss. Optimizing the coating process to control penetration depth is now a primary focus of my ongoing work. I am currently aiming for a flux of 20ul/min (as this is cap introduced by the protein gel layer anyway) but for it to be at this 'steady state' permeability without drop in permeability. I am also imaging the membranes after contact with SEM to see if there is indeed any platelet adsorption etc. Tugrul has the dubious honor of maybe being "the only person to climb a 4000m peak with severe kidney failure". To raise money and awareness for his artificial kidney project, he is running Climb Against Time, where he will climb 41 mountains over 4000m (13000 ft) this summer. He is looking for donors and climbing partners. 67: Add Tardigrade Genes To Human Cells The goal of this one was to make hybrid cells that are more resilient for research and certain medical applications. They report: The grant was to synthesize vectors for the expression of humanized tardigrade proteins that can be targeted to different areas of the cell. All the vectors were designed, generated, and transposed into human cells. The proteins all localize successfully (e.g. they match the designed target), with one exception (we are still working on validating it). We've done some stress testing with the trangenic cells, but haven't reached firm conclusions yet. We've further generated some multigene designs but have not yet transposed them into cells, but should shortly. We're hoping to submit a manuscript on the first round later this year. 68: Teach Forecasting To EU Policy-Makers The original project didn't work out, but our grantee (who still prefers to remain anonymous) is now working with an EU think tank pursuing the same agenda, and has been teaching forecasting workshops to policy-makers for the past two months. 69: Platform For Single-Cell Imaging They ended up unable to accept this grant and returned the money. 70: Open Source Polygenic Predictor For EA/IQ They have an update here. They think they have a predictor that can explain 12% of variance in intelligence, and they’re working on validating it and creating an easy-to-use website. 71: Improve Flu Vaccines The grant mainly funded agent based modelling to demonstrate the benefit of pre-existing immunity to pandemic influenza if and when a future pandemic occurs (academic publication will result). The original proposal was to attempt to influence the WHO influenza strain selection process. After attending WHO meetings and a global influenza conference, I believe this is not feasible. Stakeholder feedback was the potential short term negative effect on vaccine hesitancy is believed to outweigh the less tangible future benefit. Given the conservative nature of decision makers, pandemic vaccines are likely to remain research only. There are still green shoots of research into pandemic preparedness/prevention that I am continuing to work on. I'm working under the "Australians for Pandemic Prevention" brand of Good Ancestors, another group that ACX funded in 2024. 72: Scenario Analysis For Developing World Agricultural Programs In addition to the research and analysis funded by the grant, I’ve learned to code with LLMs and have built an MVP of the project. The app is being considered for further development by staff at a large international organization. 73: Further C’s Political Career C’s political career is going well, but he continues to think it wouldn’t be strategic to give more information publicly at this time. Lessons Learned I'm most impressed with our lobbying/advocacy organizations. In particular, Good Ancestors has gotten the Australian government to sign onto an international AI safety declaration, partner with various x-risk-related organizations, and (possibly) extend charity tax deductions to some EA causes that previously didn't have it - I think this on its own goes a substantial way to paying back the cost of all ACX Grants. Coalition to Modify NOTA has a kidney donation bill in front of Congress that the (very illiquid) prediction markets give a 45% chance of passing; if it works, it could save thousands of lives. The Georgists are partly responsible for bills making land value taxes slightly easier to implement in a handful of states. Good Science Project seems to have significantly improved science. Are lobbying organizations a better bet than other types of nonprofit (within the constraints of ACX Grants)? I'm not sure. It could just be that lobbyists are (naturally) better at playing themselves up and sounding successful than (for example) scientists, or that politicians are good at people-pleasing and make people feel heard and encouraged in a way that might not change overall policy later. Also, I recently talked to some grantmakers who funded a lobbying organization that superficially seems excellent, but they expressed concern it was net negative (!) by taking away oxygen and spotlight from potentially more effective orgs. So I am encouraged but wary. Animal welfare organizations were another standout success. Again, I don't know how to think about this - while I think our grantees were exceptional, there's also an issue where the scale of animal welfare challenges is so great, and work on them so neglected, that lots of organizations can save a million chickens here, or a million fish there, without particularly making a splash. On the one hand, this is exactly what effective altruism should be doing - exploring grants that are very high in linear utility even if they don't feel satisfying. On the other, they're unsatisfying - and also hard to assess retroactively. How many chickens should a good animal welfare grant save? Any realistic number will both be overwhelmingly large in absolute terms and far too small in relative terms. I'm most ambivalent about our science grants. Many of them say they are successful and can point to published papers which explain the science they did. But it's hard to judge whether anything useful has changed based on the science getting done. I know it's important to fund basic research and not just last-mile technology startups, but it's hard for a mini-grants program like this one to evaluate these kinds of abstract interventions. One disappointing result was that grants to legibly-credentialled people operating in high-status ways usually did better than betting on small scrappy startups (whether companies or nonprofits). For example, Innovate Animal Ag was in many ways overdetermined as a grantee - former Yale grad and Google engineer founder, profiled in NYT, already funded by Open Philanthropy - and they in fact did amazing work. On the other hand, there were a lot of promising ACX community members with interesting ideas who were going to turn them into startups any day now, but who ended up kind of floundering (although this also describes Manifold, one of our standout successes). One thing I still don't understand is that Innovate Animal Ag seemed to genuinely need more funding despite being legibly great and high status - does this screen off a theoretical objection that they don't provide ACX Grants with as much counterfactual impact? Am I really just mad that it would be boring to give too many grants to obviously-good things that even moron could spot as promising? Someone (I think it might be Paul Graham) once said that they were always surprised how quickly destined-to-be-successful startup founders responded to emails - sometimes within a single-digit number of minutes regardless of time of day. I used to think of this as mysterious - some sort of psychological trait? Working with these grants has made me think of it as just a straightforward fact of life: some people operate an order of magnitude faster than others. The Manifold team created something like five different novel institutions in the amount of time it's taken some other grantees to figure out a business plan; I particularly remember one time when I needed something, sent out a request to talk about it with two or three different teams, and the Manifold team had fully created the thing and were pestering me to launch a trial version before some of the other people had even gotten back to me. I take no pleasure in reporting this - I sometimes take a week or two to answer emails, and all of the predictions about my personality that this implies would be correct - but it's increasingly something that I look for and respect. A lot of the most successful grants succeeded quickly, or at least were quick to get on a promising track. Since everything takes ten times longer than people expect, only someone who moves ten times faster than people expect can get things done in a reasonable amount of time. In almost every case where I thought to myself “this is a cool idea, but I don’t know how it’s going to really pay off, as opposed to reaching a cool intermediate accomplishment and then stagnating”, this was a correct criticism, and I should have taken it more seriously. But I can’t rule out that these were good in vague and hard-to-measure ways that I should take more seriously. This one is really self-serving, but in general when people were good communicators (or even bloggers) and wowed me with the writing-composition of their application, they turned out to be a good bet. And when people were hard to understand and annoying to communicate with, even if their ideas seemed good, they were less likely to pan out. Overall Thoughts The total cost of ACX Grants, both rounds, was about $3 million. Do these outcomes represent a successful use of that amount of money? Very naively, startups originating from ACX Grants have about $50 million in value1. If ACX Grants is equivalent to a pre-seed funder, and pre-seed funders usually get ~5%, then if we were VCs we would have a portfolio worth $2.5 million. About 1/5 of ACX Grants were attempting to be market-valued startups, so if we assume the charitable portion did about as well as the startup portion, then the charity portion is “worth” $10 million. There’s some reason to expect this is too high, since much of the startup value came from one successful outlier. But there’s another reason to expect this is too low, since we were aiming at charity rather than market cap, and any actual market cap that our grantees got was an unexpected side effect. I’m treating this as a sanity check rather than as a real number. It’s harder to produce Inside View estimates, because so many of the projects either produce vague deliverables (eg a white paper that might guide future action) or intermediate results only (eg getting a government to pass AI safety regulations is good, but can’t be considered an end result unless those regulations prevent the AI apocalypse). Because we tend towards incubating charities and funding research (rather than last-mile causes like buying bednets), achieved measurable deliverables are thin on the ground. But here are things that ACX grantees have already accomplished: Improved the living/slaughter conditions of 30 million fish.
Inline links: Progress and Poverty Substack, Climb Against Time, here, 1
polygenic embryo screening1 mentions across 1 issues

polygenic embryo screening is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between July 12, 2024 and July 12, 2024. The archive places it in contexts such as "modern companies offering polygenic embryo screening". It most often appears alongside 1980s, 1989, 1990s.

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1
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1
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July 12, 2024
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July 12, 2024
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Your Book Review: The Family That Couldn’t Sleep
July 12, 2024 · Original source
Draw your preferred parallels to modern companies offering polygenic embryo screening.
polygenic embryo selection1 mentions across 1 issues

polygenic embryo selection is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between July 24, 2024 and July 24, 2024. The archive places it in contexts such as "Harvard Medical School poll on Americans’ support for polygenic embryo selection"; "geneticist Sasha Gusev has a critique of (existing) polygenic embryo selection". It most often appears alongside Abigail Shrier, Adragon De Mello, AI girlfriends.

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1
Issue count
1
First seen
July 24, 2024
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July 24, 2024
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Links for July 2024
July 24, 2024 · Original source
29: Harvard Medical School poll on Americans’ support for polygenic embryo selection. Overwhelming support for selection for serious disease, but 35% support vs. 45% oppose selecting for IQ. The ordering isn’t what I would have guessed either; people are more opposed to selecting for life satisfaction (and baldness!) than for intelligence.
Inline links: Harvard Medical School poll on Americans’ support for polygenic embryo selection
30: Related: geneticist Sasha Gusev has a critique of (existing) polygenic embryo selection. He thinks it has medium ability to select against “threshold” traits like disease (10% reduction by avoiding high-risk embryos, ~50% by choosing the lowest-risk) and (what he describes as) relatively low ability to select along “continuous” traits like IQ (+4 points if you’re lucky, though I know other people working on this who say +6). I think these are the right numbers, but he’s underestimating how much you should want an extra 4-6 IQ points - something I would gladly take over a 50% absolute reduction in hypertension risk or whatever. And I would very gladly take it over the alternative of not doing polygenic screening at all and getting nothing.
Inline links: a critique of (existing) polygenic embryo selection
polygenic prediction1 mentions across 1 issues

polygenic prediction is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between July 31, 2025 and July 31, 2025. The archive places it in contexts such as "Polygenic prediction of traits in adults is still young and full of hidden pitfalls". It most often appears alongside 23andMe, 23andme, Alex Young.

Reference entry
polygenic prediction
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1
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1
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July 31, 2025
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July 31, 2025
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Suddenly, Trait-Based Embryo Selection
July 31, 2025 · Original source
Sample Nucleus results. And this week, Herasight4 entered the space with the most impressive disease risk scores yet, an IQ predictor worth 6-95 extra points, and a series of challenges to competitors, whom they call out for insufficient scientific rigor. Their most scathing attack is on Nucleus itself, accusing its predictions of being misleading and unreliable. Let’s start with the science, then move on to the companies and see if we can litigate their dispute. In Theory, All Of This Should Work Polygenic embryo screening is a natural extension of two well-validated technologies: genetic testing of embryos, and polygenic prediction of traits in adults. Genetic testing of embryos has been done for decades, usually to detect chromosomal abnormalities like Down Syndrome or simple single-gene disorders like cystic fibrosis. It’s challenging - you need to take a very small number of cells (often only 5-10) from a tiny proto-placenta that may not have many cells to spare, and extract a readable amount of genetic material from this limited sample - but there are known solutions that mostly work. But most traits are polygenic, requiring information about thousands or tens of thousands of genes to predict. These are too complicated to understand fully at current levels of technology, but some studies have chipped away at the problem and gotten a partial understanding. Often this looks like being able to predict a few percent of the variance in a trait, and determine whether someone’s genetic risk is slightly higher or lower than average. Polygenic prediction of traits in adults is still young and full of hidden pitfalls. Last month, we discussed how some early studies unknowingly conflated direct genetic effects and various confounders6 - for example, they tended to pick up on genes associated with well-off ethnic groups or families who had good health outcomes for social reasons. Pinpointing the direct component requires an additional step where researchers validate their algorithms within families (for example, on pairs of siblings where one has a higher polygenic score than the other) to see how much predictive power remains. This is especially important for embryo selection companies, whose entire value proposition depends on comparing two genomes from the same family. How have they done? It depends on the number of embryos they have to work with; the more embryos, the better you can do by selecting the best. Herasight’s numbers on how breast cancer risk goes down with number of embryos used in selection. A typical round of IVF produces 1-10 embryos (younger women usually = more). Women with polycystic ovarian syndrome (prevalence: 10%) may get as many as 20. For more, you will probably need to do multiple IVF rounds. Here is a table of different companies’ reported risk reductions, slightly adjusted7 for different reporting conventions but otherwise taking all claims at face value (we’ll talk about how wise that is later). Relative risk reduction for five conditions (gray = no data / disputed data). Here baseline is for embryos neither of whose parents have the condition. GP and Orchid both say their technology has improved since reporting these numbers and they will report better numbers soon. GP numbers are not within-family validated and might be lower if they were. Absolute risk after selection for five conditions (gray = no data / disputed data), ibid. Some people might genuinely want to select on a single condition. For example, people with a strong family history of schizophrenia might want to minimize the chance of their children getting the disease; for these people, reducing schizophrenia risk by 58% (while keeping everything else constant) sounds pretty good. Everyone else probably wants a generically healthy embryo with low risk of all conditions. Exactly how this works depends on the customer’s own values - would they prefer an embryo with lower cancer risk to one who will have fewer heart attacks? - and the exact benefits will depend on how parents make that decision. Genomic Prediction and Herasight try to help by providing semi-objective measures of which embryo is overall healthiest according to different conditions’ effects on longevity and patient-rated quality of life. For Genomic Prediction, that’s the “embryo health score” If you selected the single highest-health-score embryo from a set of five, here’s how they’d do: For Herasight, it’s a “polygenic longevity index”. They don’t give exact risk reduction numbers for each disease, saying that it depends too much on a couple’s specific family history, but say that most people gain 1-4 years of healthy life (when I test it on a set of twenty embryos, the the healthiest gets an extra 1.66 years). How much would you pay to give your children an extra 1-4 years of healthy life? This is no longer a hypothetical question. Here are the costs of the companies in this space: Is it worth it? If: You’re already doing IVF
Inline links: Herasight, 4, 5, 6, https://substackcdn.com/image/fetch/$s_!VOdq!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fb1ba32f3-72fa-4be1-846c-6b0b04a5a213_774x279.png, 7, https://substackcdn.com/image/fetch/$s_!0oUh!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fe8419603-9239-43bb-8c79-77b078ff0789_548x136.png, https://substackcdn.com/image/fetch/$s_!rpEJ!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fc539a717-a130-460d-90c9-4ab64619f26d_548x133.png, https://substackcdn.com/image/fetch/$s_!3Kc6!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fbda325bb-13fb-4c27-b8c3-24facce5c71a_676x153.png, https://substackcdn.com/image/fetch/$s_!t1Am!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F831ab3c6-4053-4ff9-bc2f-879aee4349cf_673x740.png, https://substackcdn.com/image/fetch/$s_!Q2vE!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fadcf2bb4-8dd1-4a88-9728-6953a820971b_422x575.png
polygenic scores1 mentions across 1 issues

polygenic scores is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between June 26, 2025 and June 26, 2025. The archive places it in contexts such as "polygenic scores, GWAS, GREML, RDR, and Sib-Regression are also strong designs". It most often appears alongside Aftab, Alex Young, Arthur Jensen.

Reference entry
polygenic scores
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1
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1
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June 26, 2025
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June 26, 2025
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Missing Heritability: Much More Than You Wanted To Know
June 26, 2025 · Original source
By the early 2000s, genetic science reached a point where scientists could start pinpointing the particular genes behind any given trait. Early candidate gene studies, which hoped to find single genes with substantial contributions to IQ, depression, or crime, mostly failed. They were replaced with genome wide association studies, which accepted that most interesting traits were polygenic - controlled by hundreds or thousands of genes - and trawled the whole genome searching for variants that might explain 0.1% or even 0.01% of the pie. The goal shifted toward polygenic scores - algorithms that accepted thousands of genes as input and spit out predictions of IQ, heart disease risk, or some other outcome of interest.
Twin studies suggested that IQ was about 60% genetic, and EA about 40%. This seemed to make sense at the time - how far someone gets in school depends partly on their intelligence, but partly on fuzzier social factors like class / culture / parenting. The first genome-wide studies and polygenic scores found enough genes to explain 2%pp1 of this 40% pie. The remaining 38%, which twin studies deemed genetic but where researchers couldn’t find the genes - became known as “the missing heritability” or “the heritability gap”.
Inline links: 1
Maybe there are genes we haven’t found yet For most of the 2010s, hypothesis 2 looked pretty good. Researchers gradually gathered bigger and bigger sample sizes, and found more and more of the missing heritability. A big 2018 study increased the predictive power of known genes from 2% to 10%. An even bigger 2022 study increased it to 14%, and current state of the art is around 17%. Seems like it was sample size after all! Once the samples get big enough we’ll reach 40% and finally close the gap, right? This post is the story of how that didn’t happen, of the people trying to rehabilitate the twin-studies-are-wrong hypothesis, and of the current status of the debate. Its most important influence/foil is Sasha Gusev, whose blog The Infintesimal introduced me to the new anti-hereditarian movement and got me to research it further, but it’s also inspired by Eric Turkheimer, Alex Young (not himself an anti-hereditarian, but his research helped ignite interest in this area), and Awais Aftab. (while I was working on this draft, the East Hunter Substack wrote a similar post. Theirs is good and I recommend it, but I think this one adds enough that I’m publishing anyway. You can see Gusev’s response to East Hunter here) In an interview with Aftab, Gusev explained his philosophy like so (I am excerpting heavily from a long interview and editing for flow/emphasis; completionists should read the whole thing): For teacher-reported ADHD, the twin heritability estimate was 69% while the GWAS-based heritability estimate [ie using genome-wide association studies where researchers actually try to find the genes involved] was just 5%; with similar gaps for other behavioral traits. These are huge differences! If we believe the twin study estimates, then this gap implies that there is a lot of causal genetic variation out there that GWAS/molecular data is not picking up. One way to think about this is that traits that are under stronger natural selection will have more of their genetic variants driven to low frequency, and thus less detectable by GWAS. So a big gap between GWAS and twins could imply that rare variants are very important due to strong selection. On the other hand, if we are skeptical of the twin study estimates, then this gap implies a substantial contribution from those environmental complexities I talked about previously. For a long time, the field of molecular genetics was operating under the assumption that the missing heritability was largely in the rare variants we had not yet measured. But a number of recent advances have started to tip the scales against that argument. First, some of the earlier molecular heritability estimates were found to be inflated by some mix of technical issues and cultural transmission, so the amount of missing heritability actually increased. Second, a new model was developed that could estimate total direct heritability using molecular data from mother-father-child trios, with very few model assumptions (the title literally states “… without environmental bias”; Young et al. 2018), and it too found estimates that were substantially lower than twins on average. Third, several studies have now actually measured the influence of rare variants in various forms, and they are so far not adding up to explain as much as we would expect from twin heritability estimates. Fourth, there is little evidence of the strong natural selection that would be needed to generate a massive trove of rare variants untagged by GWAS. I am a molecular geneticist, and this drumbeat of evidence from molecular data has convinced me that twin studies are either 2-3x inflated or estimate something fundamentally different from direct heritability. We’ll start by looking at Gusev’s first claim: that “earlier molecular estimates” (ie polygenic scores) are significantly inflated, or at least don’t mean what we thought they meant. This won’t be directly relevant to our question - even our original number of 17% implies missing heritability2, so moving it down a bit to 5-10% or up a bit to 20% doesn’t add or subtract from the fundamental mystery. But this discussion has gotten a lot of people extremely confused, and we’ll need to deconfuse ourselves if we’re going to get any further. Are Most Current Polygenic Scores Confounded? A polygenic score is one possible result of a genome-wide association study. These scores are algorithms which take a person’s genes as input and return information about their traits as output. Better polygenic scores can predict a higher percent of variance in a certain trait. For example, the latest polygenic score on educational attainment can predict up to 17% of the variance in how much schooling someone completes. Predictive power is different from causal efficacy. Consider a racist society where the government ensures that all white people get rich but all black people stay poor. In this society, the gene for lactose tolerance (which most white people have, but most black people lack) would do a great job predicting social class, but it wouldn’t cause social class3. It certainly wouldn’t be a “gene for social class” in the sense where it controls the part of your brain that helps you manage money, or where genetic engineering on this gene would make people richer. Here are three common ways that not-directly-causal genes can show up as predicting a trait: Population stratification: genes are linked to culture, and culture determines the trait, as in the racism-lactose example above. Many studies naturally mitigate this concern by using the UK Biobank of mostly white British samples, and by correcting for “principal components” that correspond to ancestry (and there are other, even more complicated ways to correct for this). But ancestry variation is fractal; no matter how uniform your sample, there will still be micro-differences you didn’t consider. For example, if you’re analyzing the educational attainment of white British people, it’s very relevant that families with Norman surnames still outperform their Saxon peers at Oxbridge admissions 900 years after William the Conqueror. If Britons with more Norman ancestry have non-education-related genes that their Saxon peers lack, these could be mistakenly classified as genes for education or other behavioral differences between the two groups. Assortative mating: Suppose that both height and wealth are desirable qualities in a mate. Then tall people will tend to marry rich people, and over generations, the same people will be both rich and tall. That means that even if wealth is 0% genetic, a study looking for “the gene for wealth” will be able to find genes that rich people have more often than poor people - namely, the genes for height. Or suppose that smart people tend to marry other smart people - surely true, if only because so many couples meet at college. Then all the intelligence genes will concentrate in the same people. So any study that tries to determine how much Intelligence Gene ABC affects intelligence will get inflated4 results, because everyone with Intelligence Gene ABC will also have many other intelligence genes - if the study naively asks “How much smarter are people with Gene ABC than people without it?”, it will find they are much smarter (because it’s accidentally including part of the effects of all the other intelligence genes that travel along with it). Parent-to-child transmission, aka “genetic nurture”: Children tend to share their parents’ genes. So if there’s a gene that causes parents to create a certain kind of childrearing environment, and that childrearing environment affects a trait, it will falsely look like a gene that directly causes the trait. Suppose Gene XYZ causes parents to read more books to their children, and reading books to children increases their IQ. Parents with Gene XYZ will tend to read books, so their kids will get high IQ. Those kids will also (probably) inherit Gene XYZ from their parents. So people with Gene XYZ will tend to have higher IQ. If you naively study which genes increase IQ, you’ll see Gene XYZ in more smart people than dumb people, and think it’s a “gene for IQ”. This is “causal” in a certain sense, but it’s not the one we traditionally think about, and it behaves importantly differently - for example, if you genetically engineer someone to have Gene XYZ, their IQ won’t go up (although their kids’ IQs might). How can we tell if a polygenic predictor is “direct” vs. confounded by these non-causal pathways? The most common technique is within-family comparisons: do the traditional “check if people with the gene differ on a trait from people without the gene” study, but limit its focus to (for example) sibling pairs. Suppose a couple has two children; the first child inherits Gene ABC and the second one doesn’t. If the first child is smarter than the second child, that provides some infinitesimal evidence that Gene ABC is a gene for intelligence. Repeat this process over hundreds of thousands of sibling pairs, and the infinitesimal evidence can reach statistical significance. Since the family unit is a perfect natural experiment that isolates the variable of interest (genes) while holding everything else (culture and parenting) constant, within-family results are protected against stratification, assortative mating, and genetic nurture effects. The culmination of this research program is Tan et al 2024, which finds that many polygenic predictors lose significant accuracy when retested among siblings. For example, educational attainment is 50% uncorrelated with direct genetic effects. You need to square this to figure out what percent is causal; when you do that, you find that the polygenic score that explained 14% of EA is only 4%pp direct genes, with the other 10%pp being nondirect5 confounders. So yes, it seems like most polygenic scores that don’t validate within families are confounded. However unhappy we previously were that we had only found 14% of genes for EA (vs. 40% expected), we should now be much more unhappy - we really only know 4% of genes that directly cause EA. On the other hand, you might say - so before we only knew 14%pp out of 40%. Now we only know 4%pp out of 40%. This is discouraging, but it doesn’t fundamentally change what we know about nature vs. nurture. Both 4%pp and 14%pp are less than 40% - with either number, we must be missing something or doing something wrong. Probably that’s insufficient sample size. We’ll keep working on sample size and other things, and eventually scrounge up the missing 26%pp or 36%pp or whatever of the variance, so this doesn’t change anything. All it means is that one predictive method that the average person never knew about in the first place doesn’t work as well as we thought. Who cares? Not doctors. So far this research has only just barely begun to reach the clinic. But also, all doctors want to do is predict things (like heart attack risk). They don’t care if they use causal vs. nondirect genes. It doesn’t matter if you’re “only” at higher risk of heart attack because you’re black, or Norman, or because your parents read books to you - you still need more heart attack medication! Polygenic embryo selection companies should care. They offer polygenic scores that can be used to select healthier or smarter embryos. If the predictors they use rely partly on variants that aren’t causal within families, their real benefits could be far lower than advertised. I talked to one of these companies, who said they’d already adjusted for these effects and expected their competitors had too - the proper antidote to this problem, sibling controls, is a natural choice when you’re literally picking between siblings. The biggest losers are the epidemiologists. They had started using polygenic predictors as a novel randomization method; suppose, for example, you wanted to study whether smoking causes Alzheimers. If you just checked how many smokers vs. nonsmokers got Alzheimers, your result would be vulnerable to bias; maybe poor people smoke more and get more Alzheimers. But (they hoped) you might be able to check whether people with the genes for smoking get more Alzheimers. Poverty can’t make you have more or fewer genes! This was a neat idea, but if the polygenic predictors are wrong about which genes cause smoking and what effect size they have, then the less careful among these results will need to be re-examined. But the reason I spent so much time on the subject here is that this has confused a lot of people into thinking heritability itself was confounded and is actually just 4%. When I read my first few blog posts on these findings, I came away thinking they were claiming to have discredited twin studies and heritability. And although I take partial ownership of my own poor reading comprehension, I maintain that the way that the new anti-hereditarians discuss this is pretty bad. For example, Turkheimer’s treatment of the Tan study above is called Is Tan Et Al The End Of Social Science Genomics?, and includes passages like: The median [direct genomic effect] heritability for behavioral phenotypes is .048. Let that sink in for a second. How different would the modern history of behavior genetics be if back in the 80s one study after another had shown that the heritability of behavior was around .05? When Arthur Jensen wrote about IQ, he usually used a figure of .8 for the heritability of intelligence. I know that the relationship between twin heritabilities and SNP heritabilities is complicated, and in fact the DGE heritability of ability is one of the higher ones, at .2336. But still, it seems to me that the appropriate conclusion from these results is that among people who don’t have an identical twin, genomic information is a statistically non-zero but all in all relatively minor contributor to behavioral differences. And comments included things like: I don’t know if [this study] is the end of social science genomics, but it should certainly be the end of attributing significant genetic influence to behavioral traits (despite the recent scientist-generated cartoons touting genes for “income”). And: There's no doubt that this reported findings have dealt a fatal blow to my conviction that behavioral traits are pre-eminently heritable…This is a remarkable example of an objective statistical fact mercilessly crushing the more subjective experiential sense of "A looks and acts more like B than C because A and B have the same parents." This subjective evidence is almost unshakable and universal in its application as a tried and tested psychosocial heuristic. And yet, here we are. Turkheimer is either misstating the relationship between polygenic scores and narrow-sense heritability, or at least egging on some very confused people who are doing that, and the dynamic was bad enough that I got confused myself for a while. But even more confusing, the new anti-hereditarians actually are saying that lots of behavioral traits have very low heritability! But this point requires different arguments, only tangentially related to these. So let’s move on to… Is Heritability Genuinely Low? (Part 1: GWAS & GREML) In the mid 2010s, when genome-wide association studies (GWAS) based polygenic predictors were getting better every year, it was easy to hope they might reach 40% and close the “missing heritability”. But since then, progress has stalled. The second-to-last tripling of sample size, from 300K to 1M between 2016 - 2018, increased predictive power from 6% → 12%. The last tripling, from 1M to 3M between 2018 - 2022, only increased predictive power from 12% → 14%. If you graph sample size vs. predictive power, it looks like there's an asymptote between 15 - 20% or so. (of which - remember - only 5% is directly causal!) Worse, a mid-2010s technique called GREML allowed researchers to estimate the percent of variance in a trait that comes from the sorts of common genes studied in GWAS, without having to identify the genes involved. A 2016 GREML paper suggested that the maximum share of variance that GWASs of educational attainment could ever discover was about 21% (again, compared to 40% predicted genetic from twin studies). Since unavoidable methodological issues will prevent GWASs from reaching the literal maximum possible, this agrees with the evidence suggesting an asymptote between 15 - 20%. So either twin studies are wrong and traits are less heritable than believed, or the heritability must lie somewhere other than the common genes identifiable by GWAS. What about rare genes? GWASs focus on genetic variation common enough to be worth including in a basic genetic test. Most of this is single nucleotide polymorphisms (“SNPs”). A single nucleotide is one letter of DNA - for example, a C or a G. Polymorphisms are genes that commonly vary in humans - sometimes across races (for example, some humans have a gene for light skin, and other humans have a gene for dark skin), and other times within races (for example, some white people have a gene that makes cilantro taste like soap, and others don’t). So SNPs are single-letter spots in DNA where different people often have different letters. How often? Some people say 1%, but the more practical definition is “often enough that someone has noticed and added it to the test panel”. There are three billion letters in the genome, of which only a few million are commonly-tested SNPs. But these SNP studies have limited7 ability to measure personal mutations and rare variants. Sometimes your parents’ egg and sperm cells mess up copying a nucleotide of DNA, and you get a mutation that isn’t inherited from your ethnic group or even from your subgroup/family line - it’s just some idiosyncratic DNA change that you might be the first person in history to have. Since scientists have never seen this mutation before, they don’t know about it and can’t test for it without doing something more expensive than a simple SNP screen. And SNP studies have limited ability to detect anything more complicated than a single letter changing to another single letter. But some mutations are more complicated structural variants. For example, some bits of DNA get stuck on repeat - one person might have GATGAT, another person might have GATGATGATGAT, and a third person might have fifty GATs in a row. Other bits come out backwards. Sometimes a whole chunk of DNA goes missing, or moves to the wrong place. Occasionally a gene reads The Selfish Gene by Richard Dawkins, takes it too seriously, and evolves some ridiculous trick for spamming itself all over the genome. So if even the best molecular studies seem to be asymptoting around 15-20% of variance in educational attainment, but twin studies suggest it’s 40% genetic, might rare variants and structural variants make up the missing 20-25%pp? This remains a topic of bitter disagreement. On the one side, hereditarians bring up a Darwinian argument: imagine a genetic engineer who hopes to find the genes for educational attainment and edit them to make everyone smart and successful. She looks harder and harder, becoming more and more exasperated as they fail to materialize. Finally, she realizes she’s been scooped: evolution has been working on the same project, and has a 100,000 year head start. In the context of intense, recent selection for intelligence, we should expect evolution to have already found (and eliminated) the most straightforward, easy-to-find genes for low intelligence. Therefore, everything left should be convoluted or hidden or impossible to work with. So although this requires a sort of god-of-the-gaps argument - where we keep pushing heritability into whatever genes are too weird for existing techniques to detect - there are some reasons to think God really is in the gaps here. And a 2017 paper uses some clever techniques to estimate the share of intelligence variation lurking in hard-to-measure genes and finds it’s more than half: “By capturing these additional genetic effects, our models closely approximate the heritability estimates from twin studies for intelligence and education.” (see also Wainschtein 2022, Sidorenko 2024) The anti-hereditarians disagree. They cite papers like Zeng which measure the strength of selection on intelligence and suggest that it’s too weak to concentrate so much of the variation in rare genes8. And Sasha Gusev mentions Weiner 2023, which finds that in fact rare variants “explain 1.3% (SE = 0.03%) of phenotypic variance on average – much less than common variants” (other experts say that burden heritability only captures some rare variants and is not the right tool for this problem). But it may not even matter, because another set of findings suggests that heritability is genuinely low even when the rare variants are counted. Is Heritability Genuinely Low? (Part 2: Sib-Regression and RDR) Two newer methods, Sib-Regression and RDR, ask: using what we know from genetic studies, how much genetic variation do we think exists, total, across both common and rare genes? On average siblings share 50% of genes. But there’s a little randomness in meiosis, so some siblings might share 40% and others might share 60%. The more genetic influence on a trait, the more similar sibling pairs who share 60% of their genes will be, compared to sibling pairs who only share 40% of their genes. Since 60%-gene siblings and 40%-gene siblings are both equally part of the same family, you can use these numbers to calculate heritability unconfounded by a range of family factors. This is Sib-Regression. If you do a more complicated statistical process to extend the same idea to relatives other than siblings, it’s relatedness disequilibrium regression or RDR. GWAS asks: Looking at common easy-to-study genes, how much variation in a trait have we explained right now? GREML asks: looking at common easy-to-study genes, how much variation could we ever explain? But sib-regression and RDR ask a question more like twin studies: considering all genes, whether common / rare / easy-to-study / hard-to-study, how much variation is there total? This could address the rare variant objection mentioned above. And in many ways, these techniques are better than twin studies - Sib-Regression eliminates many potential biases, and RDR eliminates even more (although it’s harder to pull off, requiring more genetic information and computational resources). These techniques are new and hard-to-use, and only a few published studies have applied them to the sorts of behavioral traits we’re interested in: Young et al (2018) did Sib-Regression and RDR to genetic data from Iceland. Sib-regression found educational attainment = 40% (±15%) heritable, and RDR found 17% (±9%) heritable. Kemper et al (2021) did Sib-Regression only to genetic data from Britain. It found educational attainment = 14% heritable. This number conflicts with the 40% from the Young paper. Why? Unclear, but it could be selection bias - Young’s Icelandic sample was representative of the country; Kemper’s British population were Biobank volunteers who tend tend to be healthier and higher-class than the population at large. Upper-class people may have restricted range in educational attainment, or different factors affecting their educational attainment compared to the overall population. Either way, these are closer to the low estimates from GWAS and GREML (7% direct, 20% total), than to the higher estimates from twin studies (40%, generally presumed direct). And we can no longer use contributions from rare variants to paper over the difference. So what is going on? It seems like we have to accept one of three possibilities: Either something is wrong with twin studies. Or something is wrong with Sib-Regression and RDR (and then we can explain away GWAS and GREML by saying they’re missing rare variants). Or something is wrong with how we’re thinking about this topic and comparing things. What’s Going On? (Part 1: Is Something Wrong With Twin Studies?) Twin studies have dominated discussion of behavioral genetics for decades, so there’s a vast literature investigating their various assumptions and whether something might be wrong with them. Here are some of the assumptions and what the research says about each. Some of these will be duplicates of the GWAS confounders above, but we’ll go through them again anyway to review how they apply to twins. 1: Parents Treat Fraternal And Identical Twins The Same: Twin studies claim that twins are a uniquely powerful genetic laboratory; both fraternal and identical twin pairs have equally concordant environments, but identical twins have more concordant genes. Therefore, the more similar identical twin pairs are relative to fraternal twin pairs, the more heritable a trait must be. But this conclusion falls apart if identical twin pairs actually have more similar environments than fraternal twin pairs do, maybe because parents (knowing their twins are identical) treat them more similarly than they would fraternal twins. Would-be twin-study-discreditors have been trying to argue that this must be true for decades, but it’s always been a kind of quixotic battle. Remember, twin studies find many behavioral traits like IQ are >60% heritable, so you would need to prove not only that parents treat identical twin pairs differently from fraternal, but that this was an overwhelming effect. Parents of identical twins would have to obsessively expose them to the exact same stimuli in the exact same order; parents of fraternal twins would have to send one to the Gifted Advanced Placement Acceleration program while locking the other in a box and force-feeding them lead pellets. Common sense tells us there are no such differences, and studies confirm this: when parents are wrong about their twins’ status (eg they have fraternal twins, but falsely think they’re identical, or vice versa) their trait similarity matches their real status, rather than the incorrect status that determined how their parents treat them; parental treatment explains less than 1% of why identical twin pairs are more concordant (2, 3, 4). See also Felson 2013, which tries to measure environmental similarity and adjust for it, with minimal effects. Are these two cuties monozygotic or dizygotic? Are you sure? (answer) 2: Fraternal And Identical Twins Have Equally Concordant Uterine Environments: Fraternal twins have different sacs in the uterus and use different placentas. Most identical twins share a placenta, and some share an amniotic sac. If trait similarity is caused by sharing a placenta or sac (maybe because the placenta is defective, the fetal brain is starved of nutrients, and so the person has a lower IQ when they grow up), twin studies would falsely read this identical-fraternal difference as genetic. Luckily this is easy to study; not all identical twins share a placenta or sac, so you can cleanly separate the effect of uterine environment from genetics. If you measure enough traits, you can find small deviations in some, but it’s not clear whether this is just multiple testing, and in any case the deviations are small. The best studies suggest this chips off somewhere between 0 - 3% from heritability estimates9. 3: There is little assortative mating: We discussed this one above in the earlier section on GWAS - smart/pretty/kind/whatever people tend to marry other smart/pretty/kind/whatever people. Why would this bias twin study results? Identical twins share 100% of their genes. Fraternal twins ought to share 50% of their genes - but they get half their genes from their mother, and half from their father. In the degenerate case where the mother and father have exactly the same genes (“would you have sex with your clone?”) even fraternal twins will be extremely similar (although not quite identical, since they’ll get different alleles from each clone). In the more plausible case where mothers and fathers are just a little more alike than chance (eg because smart people tend to marry other smart people), fraternal twins will share a genetic tendency towards a trait somewhat more than their 50% shared genes suggest. Since this makes fraternal twin pairs more (genetically) like identical twin pairs, and twin studies assess heritability as the difference in fraternal-identical-twin-pair concordance, this bias would make twin studies underestimate heritability. But this is the opposite of what you would need to “discredit” twin studies - if this bias is true, then everything is more genetic than twin studies think. And unlike the previous two biases, this one seems real and important, so much so that when you adjust for it, the heritability of educational attainment rises from ~40% to ~50%. I’m only mentioning this one here because some anti-hereditarians argue that you can’t trust twin studies because of assortative mating, without mentioning that this can only bias them down. 4: Population stratification: This is often large and worth worrying about, but it applies to identical and fraternal twin pairs equally, and doesn’t bias twin study heritability estimates much (though it might shift the balance between shared and non-shared environment). See eg the sentence around footnote 30 here. 5: Non-additive / “interaction” effects: These are theoretically interesting, but all research thus far has found they are minimal (1, 2). Some experts think this may miss rarer or harder-to-find interactions; we’ll return to this later. 6: “Genetic nurture”, parent-to-child Mentioned above: if there is a gene for reading books to kids, and reading books raises IQ, it will look like a “gene for IQ”. This isn’t as relevant to twin study estimates of heritability, since both identical twins and fraternal twins are equally related to their parents, and any trait caused by genetic nurture wouldn’t differ between them (and therefore would not falsely appear heritable in this design). Rather, they would appear as shared environment. 7: “Genetic nurture”, sibling-to-sibling That is, suppose your sibling’s traits influence your own development. For example, suppose your sibling has a gene that makes them sabotage your schoolwork, causing you to fail and drop out of school early. An identical twin would share this gene with their sibling more often than a fraternal twin, making it look like a “gene for doing badly at school” (since the people who have it do worse at school than those who don’t). Why are we even talking about this? Do we really think it’s a big part of the variance in behavioral traits? Challenging twin study heritability estimates through this route requires inhabiting a weird no-man’s-land where otherwise-invisible genetic and environmental pathways suddenly flare up when you say the magic words “it was done by a sibling”. For example, this requires a strong effect of shared environment - that is, your educational attainment has to depend on whether you’re being sabotaged or not. But in general, shared environmental effects are weak. And it requires a strong effect of genes - that is, this mechanism only works if your sibling’s tendency to sabotage you is highly genetically determined. But we’re deploying this claim to deny that traits like IQ or educational attainment are highly genetically determined. So to get much out of this, the tendency to sabotage siblings would have to be more genetic than other behavioral traits! The reason this convoluted possibility gets brought up so often is that, unlike the more plausible parent-to-child genetic nurture, twin studies can’t rule it out. So if you really want to deny twin studies, this is one of your best bets. But when investigated, this has effects indistinguishable from zero. I’ve been a bit mean in this whole section, because people really like to dismiss twin studies as “Oh, don’t you know, those depend on assumptions, I bet you never considered that assumptions might be wrong”, and then Gish Gallop you with different assumptions until you give up. But scientists have actually done a lot of really good work checking the assumptions and they mostly hold. An alternative way of validating twin studies (brought up by Noah Carl in this article) is to check them against their close cousins, adoption studies and pedigree studies. Pedigree studies investigate large family trees, and check how trait similarity decreases with genetic distance. They avoid twin specific biases (like different treatment of fraternal vs. identical twin pairs, or different prenatal environments), while adding others like assortative mating. Here are the heritabilities of IQ and EA found in pedigree studies10 (see footnote for sources and caveats, and see also here and here for somewhat similar designs): Adoption studies investigate whether adoptees’ traits are more correlated with their adoptive or biological parents. They avoid a large swathe of biases, at the risk of introducing new adoption-related biases of their own (like the possibility that agencies deliberately place adoptive children with parents who are culturally or behaviorally similar, or the possibility that adoptees were adopted late enough to still get some shared environment from their biological parents). Here are the findings of some of the largest and best11: Both straightforwardly confirmed the larger heritability numbers found in twin studies. I would add the evidence from some less formal “adoption studies”12. During residency, I spent a few months working in a child psychiatric hospital for the worst of the worst - kids who committed murder or rape or something before age 18. Many of these children had similar stories: they were taken from their parents just after birth because the parents were criminals/drug addicts/in jail/abusing them. Then they were adopted out to some extremely nice Christian family whose church told them that God wanted them to help poor little children in need. Then they promptly proceeded to commit crime / get addicted to drugs / go to jail / abuse people, all while those families’ biological children were goody-goodies who never got so much as a school detention. When I met with the families, they would always be surprised that things had gone so badly, insisting that they’d raised them exactly like their own son/daughter and taught them good Christian morals. I had to resist the urge to shove a pile of twin studies in their face. This has left me convinced that behavioral traits are highly heritable to a level that it would be hard for any study to contradict. Ultimate source here. Although the study is confusing about this, I think it’s trying to say that almost 90% of subjects were adopted before age 2. But I don’t think studies do contradict this. Given the degree to which their assumptions have been validated, and the level of confirmation from pedigree and adoption studies, I think they have earned a presumption of accuracy. Doubting the twin studies doesn’t seem like a promising route to reconciling the twin-vs-Sib-Regression/RDR discrepancy. What’s Going On? (Part 2: Is Something Wrong With Sib-Regression And RDR?) Sib-Regression is a clever way of avoiding most biases. Its independent variable - the degree to which some sibling pairs end up with slightly more shared genes than others - is even more random and exogenous than the difference between fraternal and identical twins. It can sometimes have biases related to assortative mating (which would falsely push heritability down), but otherwise it’s pretty good. RDR has many of the same advantages, and allows more diverse relationships and so larger sample sizes. It’s hard to think of ways these methods could be wildly off. There is one caveat: although RDR includes most of the rare and structural variants missed by GWAS, in theory it can miss certain ultra-rare variants which are so uncommon that they aren’t shared between some of the relative pairs used in RDR. De novo variants that occurred during the subject’s own conception would be in this category, if the subject didn’t have children or didn’t pass on that gene13. This seems like a pretty small subcategory of genetic variation, and I wouldn’t normally expect that much of importance to be hiding here, but maybe it’s more important than it seems. RDR also doesn’t include much variance caused by statistical interactions between genes. Although we said above that these are usually found to be insignificant, they might be more important in a trait like intelligence that has been under recent evolutionary selection that lops off easily-detectable sources of variance and leaves only the weird obscure ones behind. There’s limited ability for classical Mendelian dominance to affect common variants, but more complicated genetic interactions might still prove important. Overall these are strong methods, and their failure to converge is troubling. If forced to explain them away, we might tell a story like: So far, there is only one RDR study and a few Sib-Regression studies, so we should wait for more data before updating too hard.
Inline links: Sasha Gusev, The Infintesimal, Eric Turkheimer, Alex Young, Awais Aftab, wrote a similar post, here, read the whole thing, Young et al. 2018, 2, 3, families with Norman surnames still outperform their Saxon peers at Oxbridge admissions, or other behavioral differences between the two groups, 4, Tan et al 2024, https://substackcdn.com/image/fetch/$s_!ioe2!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F05c5bec7-469c-40d2-b908-68d8583c9cca_766x766.png, 5, Polygenic embryo selection, need, Is Tan Et Al The End Of Social Science Genomics?, 6, like, And, 300K, 1M, 3M, A 2016 GREML paper, 7, evolves some ridiculous trick, a Darwinian argument, a 2017 paper, Wainschtein 2022, Sidorenko 2024, Zeng, 8, Weiner 2023, other experts say, meiosis, Young et al (2018), Kemper et al (2021), their trait similarity, matches their real status, 2, 3, 4, Felson 2013, https://substackcdn.com/image/fetch/$s_!r3kV!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fd575f2d6-3619-40e6-9a5e-f9f1ec1399a5_650x422.png, answer, The best studies, 9, seems real and important, here, 1, 2, when investigated, in this article, 10, here, here, https://substackcdn.com/image/fetch/$s_!b3LF!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fc094f9c0-4c71-48cf-89dc-615498d94812_483x51.png, 11, https://substackcdn.com/image/fetch/$s_!XFWU!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F85f433e5-d141-47b7-8dc5-2271925032e9_483x102.png, 12, https://x.com/cremieuxrecueil/status/1935731422205010135, here, 13
polygenic screening1 mentions across 1 issues

polygenic screening is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between July 01, 2021 and July 01, 2021. The archive places it in contexts such as "But with polygenic screening, you start to get more options". It most often appears alongside Aurea, breast cancer, genomic indexing.

Reference entry
polygenic screening
Mention count
1
Issue count
1
First seen
July 01, 2021
Last seen
July 01, 2021
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Welcome Polygenically Screened Babies
July 01, 2021 · Original source
I often have patients ask me something like: "I have a history of schizophrenia in my family. I'm really concerned my kid might get schizophrenia. What can I do to prevent this?" Right now I don't have a lot of answers, besides just staying generally healthy during pregnancy and making sure the kid has a healthy upbringing. But with polygenic screening, you start to get more options. You can IVF lots of embryos, test all of them for genetic schizophrenia risk, and implant whichever one gets the lowest score. How much does that help? LifeView, the pioneering polygenic screening company, has some helpful calculators:
You'll notice that all the traits being measured here are pretty serious medical conditions. In theory, you're not supposed to use polygenic screening to produce designer babies. What about in practice? Screening companies will give you the raw data if you ask for it, so if you want to screen for an embryo with green eyes, all you need to do is find some third party algorithm that can screen genomes to figure out the baby's eye color and plug in your data. Does anything like this exist? I don't think so, but I think it would be trivial for a genetics PhD student to make.
[edit: existing polygenic screening companies might not read enough genes to do this. Although it would be easy to offer a more complete service that reads most genes, banning the more complete version might be one way regulators could prevent this otherwise hard-to-prevent thing.]
polygenic selection1 mentions across 1 issues

polygenic selection is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between July 31, 2025 and July 31, 2025. The archive places it in contexts such as "The final step was polygenic selection - genotyping each embryo". It most often appears alongside 23andMe, 23andme, Alex Young.

Reference entry
polygenic selection
Mention count
1
Issue count
1
First seen
July 31, 2025
Last seen
July 31, 2025
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Suddenly, Trait-Based Embryo Selection
July 31, 2025 · Original source
When a couple uses IVF, they may get as many as ten embryos. If they only want one child, which one do they implant? In the early days, doctors would just eyeball them and choose whichever looked healthiest. Later, they started testing for some of the most severe and easiest-to-detect genetic disorders like Down Syndrome and cystic fibrosis1. The final step was polygenic selection - genotyping each embryo and implanting the one with the best genes overall.
Inline links: 1
Best in what sense? Genomic Prediction claimed the ability to forecast health outcomes from diabetes to schizophrenia. For example, although the average person has a 30% chance of getting type II diabetes, if you genetically test five embryos and select the one with the lowest predicted risk, they’ll only have a 20% chance2. Since you’re taking the healthiest of many embryos, you should expect a child conceived via this method to be significantly healthier than one born naturally. Polygenic selection straddles the line between disease prevention and human enhancement.
Inline links: 2
A European family with five embryos and no family history can cut their diabetes risk by 47%, and an African family 29%, with everyone else in between. As usual, all companies say that they adjust their scores based on the couple’s genetic ancestry. As usual, Herasight challenges them to publicly release data on exactly how they performed the adjustments and how well they work. All companies say they are working as hard as they can to improve cross-ancestry portability, but that progress will remain limited until governments collect/release better genetic data on non-white populations. Ethical Objection: Selection At some point, you’ve got to choose. Genomic Prediction and Herasight offer scores that aggregate overall health risks. Some people will follow them slavishly. Other people will try to second-guess them - would you prefer your child have lower cancer risk, or less chance of heart attacks? And this is the best case scenario! Herasight offers predictors for IQ, height and BMI; Nucleus offers those plus eye color and hair color12. A parent might encounter a situation where the embryo with their favorite eye color also has the highest cancer and schizophrenia risk, and choose to doom their child to cancer and schizophrenia because they really want pretty eyes. On average, even if everyone in the world selected for eye color, it wouldn’t raise cancer and schizophrenia risk. No not-deliberately-perverse polygenic selection choice can make your child worse off in expectation. Still, suppose you got cancer, and your mom admitted that she selected you for pretty eyes and didn’t even check the cancer column of the embryo selection report. How would you feel? And would you feel better or worse than someone whose parents didn’t do embryo selection at all, and spent the money on a Caribbean vacation? What if they selected your brother for everything great, then had you naturally? What if they selected you for IQ, but actually you are very stupid, and you were one of the 20% of cases where a predictor that’s right 80% of the time gets it wrong? Mark my words, one day there will be entire subfields of therapy dedicated to these issues. Going Nuclear Even as outsiders criticize the whole field, Herasight has launched a full-scale attack on competitor Nucleus. Herasight’s white paper compares its own predictors (favorably) to those of Orchid and Genomic Prediction… …but refuses to acknowledge Nucleus at all. In a supplementary note, the authors explain why: they accuse Nucleus of being so bad that it would “not yield a reliable or meaningful addition to our analysis”. They say Nucleus has inflated the accuracy of their scores. This is most dramatic for a few conditions like ADHD, where the leading published polygenic score is based on 2,300,000 variants but explains only ~1% of variance in the condition. Nucleus’ score is based on 12 variants13 and (implicitly) claims to explain 3-6%. This doesn’t make sense. Some of Nucleus’ other scores do use millions of variants. But many of these are 5-10 year old scores downloaded from open-source catalogs, whose accuracy statistics are easily available and far less than Nucleus claims. Here is what Herasight finds when they double-check Nucleus’ numbers: On their Substack, Herasight also criticizes Nucleus’ monogenic screening product. They point out cases where it fails to properly screen for the conditions it claims. For example, the Nucleus website advertises screening for spinal muscular atrophy: But on their gene list… …they don’t screen for SMN, which causes 95% of spinal muscular atrophy cases. They only screen for UBA1, which causes a distinct and much rarer condition called x-linked infantile spinal muscular atrophy. Professional organizations publish guidelines for what genes need to be screened in a screening product, and Nucleus does not appear to be following them. In further discussion, Herasight continued with exhaustive criticism of essentially everything Nucleus had ever done down to the smallest detail. Nucleus reports list the same baseline disease risk regardless of patient ancestry, but different ancestry groups should have different risks14. Nucleus’ physician reports sometimes list lower-than-average risk for patients with positive polygenic scores15. Nucleus’ age-based risk tables don’t distinguish between age and cohort effects (is this bad? see footnote16). My favorite critique is that Nucleus wrote a blog post criticizing competing company Orchid… …which included a section on how Orchid is a polygenic selection company, and polygenic selection companies are inherently “sketchy” and “honestly should be illegal”. But Nucleus is also a polygenic selection company! This is like Marlboro attacking Camel on the grounds that cigarettes are addictive and should be banned! Obviously something went wrong here - my guess is AI - and it’s a really bad look, especially when these scientific issues are so hard to litigate, and so many of us will have to go off gestalt impressions of corporate culture. Nucleus states that they validate their models internally and intend to make their results public soon. A Foothill Of The Future It’s hard not to love this technology. Lots of people (and the aforementioned professional organizations) manage anyway, but it’s hard. If this were a single-use medical treatment, delivered by a doctor after someone got the relevant condition, it would be one of the biggest advances of the decade - imagine a drug that cures 10 - 40%17 of breast cancers with no side effects! But in fact, it works for breast cancer, and schizophrenia, and heart attacks, and approximately everything else. The only things comparable are antibiotics and GLP-1RAs. And then there’s the IQ effects. Even after studying the literature, people have wildly different opinions about the importance of IQ. One of the most important debates is to what degree IQ differences are a cause of poverty, a consequence of poverty, or both. I lean towards both - a country with limited access to schools and medical care will have low average IQ, but as a consequence it probably won’t become the next big semiconductor hub. This technology could close half the IQ gap between poor and middle-income countries, or between middle-income and rich. Or it could give rich countries average IQs that have never been seen before, and let us see what kind of O-ring technologies (and new forms of social cooperation) lie just beyond the frontier. (this is the nice quantifiable argument in favor of IQ enhancement, but I find myself more convinced by fuzzier things - how much is it worth to be able to enjoy great art and literature? To fully comprehend what we know of nature, and be able to fully appreciate the mystery of the rest? To have a sense of why society works the way it does, instead of feeling like you’re being blown back and forth by institutions you don’t really understand? Amateur psychoanalysts like to say that the only people who care about IQ are those looking for an excuse to boast about how high their own is, but my experience is the opposite: I care about IQ because I bang up against the limits of my own a thousand times a day, and I hate it. I fantasize about ways to make my children smarter than I am for the same reason a dog confined in a tiny crate might fantasize about getting her puppies adopted out to a nice house with a big grassy yard.) My biggest qualm is that it might not matter. This is such a tiny foothill, flanking such a vast and foreboding range of mountains, that it might be a mistake to care about it at all. Selecting the best of five or ten embryos is not a very effective way to get the genes you want. There are things in the pipeline that will make this look like Hippocrates draining black bile. By the time the first polygenically selected children are adults, they’ll be old news. And then there’s AI. The average age at diagnosis for Type II diabetes is 45 years. Will there still be people growing gradually older and getting Type II diabetes and taking insulin injections in 2070? If not, what are we even doing here? Many people in the transhumanist community are still bullish on this technology. They think - well, there’s still an outside chance that something comes up and AGI takes another few decades. If we can enhance humans to be smarter, healthier, and more determined by the time it arrives, maybe we’ll have a better chance. Or maybe, if there’s a positive optimistic vision of a human-based high-tech future, people will be more willing to delay AI in the first place. I like this argument, but I also think it’s worth stepping back. What’s the point of anything? Why have kids at all in a world that’s changing this fast? Why save for the future? At some point your answer has to be romantic and aesthetic - it’s never been clear whether anything you do matters in any ultimate sense, but you’ve got to act as if it does and hope for the best. From that perspective, this is the most romantic technology of all. You’re not just giving a better life to your kids. Genes travel from generation to generation; you’re giving a better life your grandkids, your great-grandkids and so on to the point 1.77*log₂(population) generations from now when you are the ancestor of everybody and nobody. Somebody in Macaronesia in 3525 AD will avoid getting breast cancer because of you (if there is still cancer; if there are still breasts). Some combination of reasonable cost-benefit analysis and romantic/aesthetic commitments makes me want to have children despite the uncertainty, and the same combination made me sign up to use this technology despite the same. More later on how that’s going. 1I’m slightly mixing up two different things here - Down Syndrome can be detected with an aneuploidy test, but cystic fibrosis takes a more involved PGT-M test. 2There are two separate questions here. First, how much would diabetes risk decline if you selected the embryo with the lowest risk for diabetes - something you have no reason to do, since you have no reason to privilege diabetes risk over risk of any other disease? Second, how much would diabetes risk go down if you selected the embryo with the lowest health risk overall? Genomic Prediction’s their risk calculator calculator shows, seemingly paradoxically, that you get -38% relative risk by selecting against diabetes alone, but -41% relative risk by selecting against everything at once. Over email, they stand by this surprising result, saying that “for a couple of diseases (type II diabetes and CAD), the EHS actually accomplishes a larger risk reduction than the individual predictors. The explanation is that the EHS takes into account multiple PRS of diseases with high comorbidity”. See eg Figure 3 here: …and the section of the post called “Antagonistic Pleiotropy” for more. However, this paradoxical benefit is only true for a few conditions like diabetes - for everything else, selecting on health index does better than you would naively think, but still does not decrease the risk of a given condition as much as selecting against that condition directly. 3That is, new mutations in that particular baby, as opposed to older mutations already present in the parents. 4Conflicts of interest: I have used Orchid’s and Herasight’s products on my own embryos (not the ones used to conceive my existing kids, but for a potential third child), employees of Genomic Prediction and Herasight have been extremely helpful in contributing expertise to ACX posts on genetics, and I might invest in this field at some point (though haven’t done so yet). This post started as Herasight asking me to write about their white paper, then spiraled out of control. There were some unexpected time pressures and the result is that I didn’t get a chance to run everything in Herasight’s white paper by their competitors as thoroughly as I would like. Although I talked to representatives of all four companies profiled here, I feel like this probably reflects Herasight’s perspective better than other companies’, and that this is a major flaw. If other companies have responses, I’ll publish them. Thanks to all companies involved for their assistance on this article. Finally, I am favorably disposed toward Herasight because of how I learned about them: a professor named Jonathan Anomaly got cancelled from Penn for being too gung-ho about genetic enhancement, and used his newfound freedom to join a very-early-stage Herasight, raise their ambitions, and sell everyone (including me) on the idea. I grew up on a diet of books and movies about mad scientists, and I’m a sucker for a story about a guy named Doctor Anomaly pursuing revenge against the small-minded fools who destroyed his career by creating a race of superbabies. 5The version of the tool I looked at said 5.9 points for five embryos, up to 9 points for twenty embryos. The version of the tool on their current said says 5.3 - 9, so they might have recalculated after I finalized this article. 6Used in quotation marks because these scores were fine for the predictive tasks they were applied for - they just weren’t finding genes that directly caused the outcome of interest. 7Conflict of interest notice: this table was originally unadjusted. A representative of Herasight claimed that this was unfair, because each company used slightly different reporting conventions, and offered to correct for this in a neutral way. I retraced their reasoning, confirmed that the correction did not especially benefit Herasight at the expense of other companies, and accepted the correction. The original unadjusted table is below: Herasight was insufficiently comfortable with Nucleus’ methodology to even be willing to posit a corrected value, so I left their self-reported value in gray. 8Zagorsky (2007) says an extra IQ point means $234-$616/year in higher salary. The midpoint of $425 equals $670 in today’s dollars; assuming a forty-year career, Nucleus’ +1 point estimate is worth $26,800 (vs. $9,249 Nucleus cost) and Herasight’s +6 point estimate is worth $160,800 (vs. $53,250 Herasight cost). 9As part of researching this article, I asked all four major companies about their within-family validation strategies. Here are some details: Genomic Prediction discusses their strategy in this paper. The results are complicated to interpret - the within-family numbers often have such wide error bars that they overlap with both the across-family numbers and with zero - but looking qualitatively it seems like most scores on average lose about 25% of their risk reduction ability (though averages might not be the right way to do this, and some might be much more affected than others). Their website reports unadjusted, not within-family validated numbers; GP says they say this clearly on their site (which is true), Herasight counters that they still present their numbers as applicable to embryo selection (which is also true). To get the most applicable-to-embryo-selection numbers, you might want to adjust GP’s stated numbers down somewhat; it’s hard to say exactly how much, but maybe 20 - 25%?
Inline links: 12, Herasight’s white paper, https://substackcdn.com/image/fetch/$s_!S7lY!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F738260ba-8fe2-4647-8ca2-eeb4d13e0fce_605x341.png, 13, https://substackcdn.com/image/fetch/$s_!u7YE!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F451c286b-c677-47af-8c07-f0d993a14384_612x345.png, their Substack, the Nucleus website, https://substackcdn.com/image/fetch/$s_!XmL4!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Ff77915b4-3b36-4908-8f9f-032b7cf865ff_562x432.png, https://substackcdn.com/image/fetch/$s_!bxjb!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F2df9ffe5-17a3-4448-9a20-e9b27ac9a519_1250x795.png, publish guidelines, 14, 15, 16, a blog post criticizing competing company Orchid, https://substackcdn.com/image/fetch/$s_!MZCB!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F2cf9cbf4-825b-4373-9052-80e43c36febf_718x1035.png, 17, GLP-1RAs, O-ring technologies, things in the pipeline, everybody, nobody, 1, 2, their risk calculator, everything, here, https://substackcdn.com/image/fetch/$s_!jtkY!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fd645c392-fed1-4f02-9a2e-878b8c7ef7f2_909x878.png, 3, 4, 5, 6, 7, https://substackcdn.com/image/fetch/$s_!Vimq!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fca0f1f15-268d-465a-a70f-b7f1173c6111_566x166.png, https://substackcdn.com/image/fetch/$s_!3B0A!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Faccc7a65-b142-4bf6-927d-53eb607d71ef_552x155.png, 8, 9
Polynesians1 mentions across 1 issues

Polynesians is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between October 14, 2021 and October 14, 2021. The archive places it in contexts such as "The Polynesians have long used a tea made from kava". It most often appears alongside @literalbanana, ACX, Barcelona.

Reference entry
Polynesians
Mention count
1
Issue count
1
First seen
October 14, 2021
Last seen
October 14, 2021
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Links For October
October 14, 2021 · Original source
26: The Polynesians have long used a tea made from kava to help relax, but so far nobody’s been able to turn it into a pill effectively - for some reason it only works in tea form, and the tea is annoying to prepare. Pretty-Chill on the Nootropics Depot subreddit claims to have solved this problem: kavalactones are only soluble when combined with some of the starches in kava roots, which happens in traditional tea preparation and not in the pill manufacturing process. Yes, this link is pretty close to shilling a product, but I trust this team a lot and think this is a potentially exciting development in the pharmacology of anxiety.
Inline links: claims to have solved this problem
Polytropon1 mentions across 1 issues

Polytropon is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between March 23, 2023 and March 23, 2023. The archive places it in contexts such as "Polytropon - a famously untranslatable Greek word". It most often appears alongside 1517, a priori truths, Abraham Lincoln.

Reference entry
Polytropon
Mention count
1
Issue count
1
First seen
March 23, 2023
Last seen
March 23, 2023
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Book Review: Paper Belt On Fire
March 23, 2023 · Original source
Probably it depends on the angle or something. Lindh was the only American to find Osama bin Laden in the early 2000s - he went to lots of jihadi training camps in the process of learning how to jihad, and Osama happened to be at one of them. The lesson, Walker says, is that if you want to find people who are hard to find, you need to steep yourself in their culture, truly understand them, become one with them. Good founders are hard to find. But he and Strachman went to dozens of dingy college dorms, math competitions, group houses, and hackathons, looking for people with the right sort of talent. After pooh-poohing IQ (“Marilyn vos Savant is listed as having the highest recorded IQ, and what does she do? She writes a column for a Sunday supplement in the newspaper”) he lists some of his own preferred metrics for judging would-be Thiel fellows and founders: Polytropon - a famously untranslatable Greek word (“of-many-turns”? “always-has-a-trick-up-his-sleeve” “clever bastard”?) used to describe Odysseus. Edge control - willingness to constantly surf the boundary between order and disorder Crawl-walk-run - ability to scale from a tiny startup to a big company. …and several others, including “tensive brilliance” and “Friday night Dyson sphere”. He and Danielle searched the country for people with these qualities, annoying colleges (he was banned from MIT after showing up too often to convince their students to drop out) and doing various stunts (on October 31 2017, the 500th anniversary of Luther’s theses, he nailed a list of anti-formal-education theses to the doors of the admin buildings of top colleges (“Our commercial printer had misunderstood our request and printed them on seven-foot-long scrolls. They were ridiculous . . . but it turned out for the best.”) At one point, he negotiated with a brilliant 21 year old who may have discovered a transformative diabetes therapeutic, but the hidebound conformist novelty-hating establishment refused to work with him just because he liked the Marvel Cinemat - okay, fine, he may have legally changed his name to “Tony Stark”. Still, Gibson saw past his eccentricities, helped him start his company, and gave him sage advice (he should introduce himself to other investors as “Anthony”). Skip through several more chapters of everyone hating Gibson and telling him he was wrong and refusing to give him money and cheating him out of the money he already had, and the payoff is Luminar. One of the dropouts they cultivated founded a beyond-cutting-edge lasers-for-self-driving-cars company which went public at $3 billion. 1517 made $200 million from the deal - it sounds like they had only ever raised about $25 million, so their investors must have octupled their money on that company alone. Everyone involved is now very rich, and Gibson considers his anti-education thesis on the way to being proven. The book ends with a newly-resourced Gibson continuing his quest to figure out whether and why the CIA killed his father, but it’s slow going. If any of you know a guy named Albert van Dam in Amsterdam, or how to convince Swiss banks to reveal secret account information, get in touch with him. II. A common pattern: I assert something. Everyone yells at me and tells me I’m wrong and stupid, sometimes in very colorful language. I wait, time proves me right, and I write an essay gloating educating people about this. The median comment is “of course this is true, nobody ever denied this was true, why are you wasting our time with something obvious?” I hate this and I try to avoid doing it to other people. This is too bad, because I’m tempted to say: obviously talented dropouts can start good companies. We’ve known this at least since Bill Gates dropped out of Harvard in 1975 to start Microsoft. But also, obviously they can. Brilliant and driven people can succeed whether they get a college education or not. If Bill Gates had stayed an extra two years at Harvard, he probably would have taken a few more advanced math classes not really related to programming software or running a company. So why should we even have as a hypothesis that he couldn’t start Microsoft successfully without doing that? Still, Gibson adequately proves that lots of people hated him and were sure he would fail. Either we should read this backwards - learn that there was once a time when pro-college messages were even stronger than now, so strong that people thought it was literally impossible to succeed without every single day of a four-year college application - or the critics were trying to get at something deeper they were bad at expressing. For example: what, exactly, is Gibson’s alternative to the education system? The back-of-book-blurb says Paper Belt On Fire is about “how higher education and other institutions must evolve to meet the dire challenges of tomorrow” - but evolve how? What exactly has been proven here? A few of the very brightest young people, hand-picked by an expert young-person-picker and given $100K, can become billionaires or make great discoveries without a college degree. What are the implications? Suppose you are an average college student with an average level of talent and motivation. Should you drop out and try to create a company for Peter Thiel? Based on how many average-talent people Thiel rejects, even he doesn’t think you should do that. And if you don’t have a good answer to this question - the one relevant to 99.9% of education system inmates - have you really launched a challenge to the educational system? Gibson doesn’t address this question, but I predict he would admit that, fine, he doesn’t have an alternative to the education system in the sense of “educate people this way rather than that way”. He just wants less formal education, and has proven this will work fine. True, he’s only proven it for a tiny subset of ultra-talented people. But “billionaire tech founder” is a hard job - if it wasn’t, more people would do it and reap the $1 billion reward. Proving that people can become billionaire tech founders without college degrees implicitly suggests they can be successful middle managers or budget analysts without college degrees. So the sort of companies that need middle managers and budget analysts should also consider hiring people without degrees, and the sorts of average-level-of-talent-and-motivation people who want these jobs should consider skipping college. Would this work? Probably. It worked in the early 1900s, when only 5-10% of Americans had college degrees but the country seemed about as dynamic and successful as it does now. It worked for people like George Washington, Abraham Lincoln, and Thomas Edison, none of whom went to college. It works in other countries - for example in the UK where young doctors skip undergrad and go straight to medical school, and whose patients get about the same outcomes as in the US. It works for people with impractical degrees like philosophy, who are constantly getting jobs in (and doing well in) fields that don’t require you to compare Locke vs. Leibniz’s perspective on a priori truths. So this would work if everyone agreed to do it at once, which they won’t. The way college gets you is adverse selection. Suppose that tomorrow, you - a smart and hard-working person who could easily get a college degree - decline to do so, because you appreciate Peter Thiel and Michael Gibson’s anti-institutional perspective. The pool of people without college degrees is now, to a first approximation: 200 million people who weren’t smart to get in, rich enough to afford it, or motivated enough to finish.
Inline links: his company, read this backwards
Pony Express1 mentions across 1 issues

Pony Express is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between October 12, 2022 and October 12, 2022. The archive places it in contexts such as "water was transferred from an Indian to the Pony Express to a mule". It most often appears alongside 538 deluxe model, @rcafdm, Andres.

Reference entry
Pony Express
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1
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1
First seen
October 12, 2022
Last seen
October 12, 2022
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Links For October
October 12, 2022 · Original source
11: Wedding Of The Waters: To celebrate a new highway opening in 1937, California arranged a ceremony in which water from North America’s highest (then known) lake was transferred from an Indian to the Pony Express to a mule to a covered wagon to ( . . . ) to an airplane to North America’s lowest lake.
Inline links: Wedding Of The Waters
Ponzi1 mentions across 1 issues

Ponzi is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between December 08, 2022 and December 08, 2022. The archive places it in contexts such as "everyone around you will chant in unison 'PONZIS 100% SCAMS ZERO-LEGITIMATE-USE-CASES'". It most often appears alongside ACX, Africa, Best Crypto Exchanges Of 2020.

Reference entry
Ponzi
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1
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1
First seen
December 08, 2022
Last seen
December 08, 2022
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Why I'm Less Than Infinitely Hostile To Cryptocurrency
December 08, 2022 · Original source
Go anywhere in Silicon Valley these days and start saying the word “cryp - “. Before you get to the second syllable, everyone around you will chant in unison “PONZIS 100% SCAMS ZERO-LEGITIMATE-USE-CASES SPEEDRUNNING-THE-HISTORY-OF-FINANCIAL-FRAUD!” It’s really quite impressive.
Do Vietnamese people love trading monkey gifs? Are Ukrainians especially susceptible to Ponzi schemes? Is Venezuela laden with techbros? Vietnam uses crypto because it’s terrible at banks. 69% of Vietnamese have no bank access, the second highest in the world. I’m not sure why; articles play up rural poverty, but many nations have more rural poor than Vietnam. There’s a history of the government forcing banks to make terrible loans, and then those banks collapsing; maybe this destroyed public trust? In any case, between banklessness and remittances (eg from Vietnamese-Americans), Vietnam leads the world in crypto use. Ukraine has always been among the top crypto countries: in 2021, NYT called it “the crypto capital of the world”. Again, this owes a lot to its terrible banking system. NYT describes its banks as “so sclerotic that sending or receiving even small amounts of money from another country requires an exasperating obstacle course of paperwork”, and this guy says that if you deposit more than $100,000 in a Ukrainian bank, “the chance that you get it back is very slim”. When Russia invaded, the Ukrainian government doubled down on crypto as a way for friendly Westerners to donate to the war effort - $70 million as of March. It proved so helpful that during the first month of the war, in between dodging Russian artillery shells President Zelenskyy found time to pass a law legalizing crypto and strengthening its regulatory framework. Venezuela’s economy has been in slow motion collapse for the past decade. Inflation is currently in the triple digits (remember, people worried the Democrats would lose the midterms because of a US inflation rate of 8%). If your country has a triple-digit inflation rate, you might prefer to use an alternative currency, which Venezuela’s authoritarian government tries to prevent people from doing. Cryptocurrency provides a hard-to-ban alternative which has caught on among Venezuelan hustlers and small businessmen. I personally contributed in a small way to Russia’s cryptocurrency use. I’ve been trying to help Russian ACX readers escape to other countries to avoid conscription or arrest. Of my two successes so far, both involved sending cryptocurrency to help them afford a ticket out and living expenses while they searched for a job in their new country. I’m pretty proud of this and I don’t think it would have been possible without crypto. I think a lot of Westerners want to think of developing-world uses as a boring sideshow, and highlight Westerners trading monkey gifs as the only part of crypto worth talking about. But about 66% of crypto users live in the developing world. More people own cryptocurrency in Africa than in North America. Of course a technology centered around avoiding governance and banking failures will be centered in the countries with the most governance and banking failures! Big Crypto Projects Are Very Rarely Scams I realize this is a bold sentence to use as a section header in 2022. But I recently tried to figure out the exact scam rate, and it seemed low. I searched for articles called things like The Top Crypto Projects Of 20XX, and then I checked how many of those projects, years later, had turned out to be scams.I tried my best not to cherry-pick, and to focus on the first article that Google fed me for each of various relevant search terms. I ended up using four articles for this experiment: Most Promising Crypto Projects Of 2015
Inline links: 69% of Vietnamese, a history, remittances, “the crypto capital of the world”, this guy, $70 million as of March, pass a law, More people own cryptocurrency in Africa than in North America, Most Promising Crypto Projects Of 2015
When something goes up in value 10,000x, it’s hard to think of it in any other context. Whatever it was before, now it’s “that thing which went up in value 10,000x”. And so both crypto believers and detractors have treated crypto primarily as a thing for going up in value6. Believers are excited that it did go up that much, hope it might go up more, and fall for a thousand scams that promise continuing going-up. Detractors correctly point out that buying things only insofar as they go up in value makes them Ponzis, and mock crypto for not having gone up in value enough recently.
Inline links: 6
Ponzi schemes1 mentions across 1 issues

Ponzi schemes is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between February 07, 2022 and February 07, 2022. The archive places it in contexts such as "Some of these are totally without social value, like Ponzi schemes"; "like Ponzi schemes and Bored Apes". It most often appears alongside Afghanistan, Alameda County, California, Alice.

Reference entry
Ponzi schemes
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1
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1
First seen
February 07, 2022
Last seen
February 07, 2022
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The Passage Of Polymarket
February 07, 2022 · Original source
There are lots of financial products which people want, but which regulation prevents them from having. Some of these are totally without social value, like Ponzi schemes and Bored Apes. Others have a lot of social value, like prediction markets, initial coin offering style funding schemes, and cutting middlemen out of immigrant remittances. More than a few might even have negative social value, like easy ways to buy drugs, or super-high-interest loans marketed to very impulsive people. Without passing judgment on whether these things are good or bad, they are legion. Collectively, they’re a zillion-dollar market.
Poor People1 mentions across 1 issues

Poor People is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between November 17, 2021 and November 17, 2021. The archive places it in contexts such as "as members of the class of Poor People". It most often appears alongside ACE-2 receptor, ACSH, Ahmed et al.

Reference entry
Poor People
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1
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1
First seen
November 17, 2021
Last seen
November 17, 2021
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Ivermectin: Much More Than You Wanted To Know
November 17, 2021 · Original source
I have no idea what you can and can’t do with cybernetic implants, and it seems totally possible they could mind control me or something. All of these come down to a more basic problem, which is that these are hostile aliens. Let’s start with the second word first. Because they’re alien, I can’t trust they’re on my side. Because they’re alien, their predictions feel like a black box. I don’t know if their previous predictions were 50% confidence or 99% confidence, or whether the stupid aliens made the last few predictions but it’s the smart aliens making this new prediction, or whether they’re even telling the truth when they describe previously fighting this plague on their homeworld and learning best practices. Because they’re alien, all the words they use like “quantum memetic plague” and “brain implant” feel not only beyond my understanding, but unfairly beyond my understanding, something that neither I nor anyone I trust could ever double-check. And because they’re alien, I have no idea how their technology works, and it could do all sorts of sinister things. I’m not an immunologist. I don’t have the specific expertise it would take to evaluate whether vaccines work. But one of my friends in medical school decided to do a joint MD-PhD in immunology. I didn’t follow her lead, because I didn’t want to spend my entire twenties and thirties in soul-sucking research labs trying to remember thirty different kinds of interleukins. But when I ask myself “why am I not an immunologist?” the answer is something like “because I dislike intense misery” and not “because immunologists are an alien species and I cannot possibly imagine myself becoming one”. More generally, I come from a social class where becoming an immunologist is considered a reasonable thing that might happen. Several of my friends and family members are experts in various fields (even for very loose definitions of “expert” like a really excellent social worker who other social workers trust). Even more generally, I know some basics of biology. I know why vaccines should work in theory. I know that even if somebody wanted to control you by sneaking a microchip into a vaccine, that’s impossible with current technology. I know enough about politics and economics to know it’s really unlikely that some cabal of elites has developed super-futuristic technology in secret. And I know a lot of smart people who I could ask these questions to if I were confused, and they could tell me all the stuff above. John Steinbeck said that socialism never took root in America because even the poor see themselves as “temporarily-embarrassed millionaires” rather than as members of the class of Poor People. If you’re Poor People, and they’re Rich People, maybe you’re on opposite sides and should fight. If you’re temporarily-embarrassed millionaires, and they’re normal millionaires, maybe you’re on the same side and you can trust them. In the same way, I think of myself as a temporarily-embarrassed immunologist. I don’t know all the interleukins. But I would like to believe that if I really wanted, either I or at least people I know and trust could learn immunology to a standard where we could double-check the work of the vaccine scientists. I’ve written before about filter bubbles. About half of Americans are young-earth creationists. I have nothing against these people, I don’t deliberately ostracize them - yet none of my closest hundred friends are in this category. There’s about an 0.5^100 = 10^-31 chance that would happen by coincidence. Some powerful combination of class, cultural, and geographic barriers prevent me from meeting them. Imagine someone with an equally strong bubble filtering against scientists. Such a person wouldn’t feel like a temporarily-embarrassed immunologist. They would feel like immunologists are some sort of dark and terrible figures from a shadow dimension they could never reach. They would seem like aliens. And now let’s return to that first word, “hostile”. 95% of biology professors are Democrats. Plus medical organizations keep rubbing more and more salt in the wound. If you’re a conservative, or even have conservative tendencies, these aliens surely qualify as suspicious and probably anti-Earthling. “99% of hostile aliens agree: vaccines are right for you!” Now we’re back to it not sounding so convincing. In a world where scientists seemed like hostile aliens, I would hesitate to take the vaccine. Again, ivermectin optimism isn’t exactly like vaccine denialism - it’s a less open-and-shut question, you can still make a plausible argument for it. But it’s some of the same people and follows the same dynamics. If we want to make people more willing to get vaccines, or less willing to take ivermectin, we have to make the scientific establishment feel less like an enclave of hostile aliens to half the population. Do that, and people will mostly take COVID-related advice, for the same reason they mostly take advice around avoiding asbestos or using sunscreen - both things we’ve successfully convinced people to do even without having a perfect encapsulation of the scientific method or the ideal balance between evidence and authority. But I don’t really know how to do that, and any speculation would be too political even for a section titled “The Political Takeaway”. The Summary Ivermectin doesn’t reduce mortality in COVID a significant amount (let’s say d > 0.3) in the absence of comorbid parasites: 85-90% confidence
Inline links: filter bubbles, 95% of biology professors are Democrats, more and more salt in the wound
poor prenatal nutrition1 mentions across 1 issues

poor prenatal nutrition is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between February 01, 2024 and February 01, 2024. The archive places it in contexts such as "We know many apparent risk factors for schizophrenia: poor prenatal nutrition". It most often appears alongside Awais Aftab, birth canal asphyxia, cannabis.

Mention count
1
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1
First seen
February 01, 2024
Last seen
February 01, 2024
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It's Fair To Describe Schizophrenia As Probably Mostly Genetic
February 01, 2024 · Original source
This is possible, but I think it’s false. We know many apparent risk factors for schizophrenia: cannabis use, birth canal asphyxia, social defeat, toxoplasma infection, poor prenatal nutrition. If you try to combine these into one big picture, it doesn’t work.
Inline links: cannabis use, birth canal asphyxia, social defeat, toxoplasma infection, poor prenatal nutrition
pop culture1 mentions across 1 issues

pop culture is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between February 16, 2022 and February 16, 2022. The archive places it in contexts such as "drawing on ... all of modern movies and pop culture". It most often appears alongside Abercrombie & Fitch, Athenian democracy, Athenians.

Reference entry
pop culture
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1
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1
First seen
February 16, 2022
Last seen
February 16, 2022
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Book Review: Sadly, Porn
February 16, 2022 · Original source
He’s also impressively erudite, drawing on the Greek and Latin classics, the Bible, psychoanalytic literature, and all of modern movies and pop culture. Sometimes you read the scholars of two hundred years ago and think “they just don’t make those kinds of guys anymore”. They do and Teach is one of them.
Pope1 mentions across 1 issues

Pope is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between August 01, 2025 and August 01, 2025. The archive places it in contexts such as "she would submit to no authority's judgement ... other than the Pope". It most often appears alongside Africa, Agamemnon, Age of Empires II.

Reference entry
Pope
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1
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1
First seen
August 01, 2025
Last seen
August 01, 2025
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Your Review: Joan of Arc
August 01, 2025 · Original source
Entertainingly, she does this without apparently knowing anything except war and, uh, now theology somehow? They ask her if she'd tell the Pope anything differently than she tells them and she immediately demands to be taken to the Pope.69 They ask her which Pope and she goes... the pope in Rome?
Inline links: 69
(The Avignon schism was, metaphorically speaking, last week, and in a couple decades the people trying her are going to schism briefly and elect their own Pope because they dislike the Roman one.)
The thing about all this is, though, that it's totally irrelevant to the actual situation. She can beat all the inquisitors in the room in debate, sure. That doesn't matter. The English bought her so they could kill her, ideally in a way that disgraces her king, and they aren't going to just let her go. She's the enemy's best general! When she answers all their absurd trick questions correctly, they respond by... writing down different answers than the one she gave and having her convicted based on them.70 They end up concluding that she must be a heretic because she (a) wears men's clothes and (b) refuses to submit to the Pope,71 72 then they convict her of heresy and witchcraft, tell her that if she doesn’t repent they’ll burn her and if they do they’ll let her go, then when she “repents,”73 they throw her back in prison and only give her men's clothes to wear,74 and convict her of relapsing into heresy when she wears them instead of going naked. Then they burn her!
Inline links: 70, 71, 72, 73, 74
Pope Alignment Research1 mentions across 1 issues

Pope Alignment Research is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between May 27, 2024 and May 27, 2024. The archive places it in contexts such as "no, “Short Women In AI Safety” and “Pope Alignment Research” aren’t what they sound like". It most often appears alongside Astralcodexten, DaystarEld, Jordan Braunstein.

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1
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1
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May 27, 2024
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May 27, 2024
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Open Thread 331
May 27, 2024 · Original source
(just in case you have the same question everyone else did - no, “Short Women In AI Safety” and “Pope Alignment Research” aren’t what they sound like; SFF unwisely started some entries with the name of the project lead, and these were led by people named Short and Pope.)
Popperian1 mentions across 1 issues

Popperian is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between March 30, 2023 and March 30, 2023. The archive places it in contexts such as "your inner Hayekian (Popperian?) has to take over". It most often appears alongside 21st century American society, AGI, Eliezer.

Reference entry
Popperian
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1
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1
First seen
March 30, 2023
Last seen
March 30, 2023
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MR Tries The Safe Uncertainty Fallacy
March 30, 2023 · Original source
Therefore, it’ll be fine. You’re not missing anything. It’s not supposed to make sense; that’s why it’s a fallacy. For years, people used the Safe Uncertainty Fallacy on AI timelines: Eliezer didn’t realize that at our level, you can just name fallacies. Since 2017, AI has moved faster than most people expected; GPT-4 sort of qualifies as an AGI, the kind of AI most people were saying was decades away. When you have ABSOLUTELY NO IDEA when something will happen, sometimes the answer turns out to be “soon”. Now Tyler Cowen of Marginal Revolution tries his hand at this argument. We have absolutely no idea how AI will go, it’s radically uncertain: No matter how positive or negative the overall calculus of cost and benefit, AI is very likely to overturn most of our apple carts, most of all for the so-called chattering classes. The reality is that no one at the beginning of the printing press had any real idea of the changes it would bring. No one at the beginning of the fossil fuel era had much of an idea of the changes it would bring. No one is good at predicting the longer-term or even medium-term outcomes of these radical technological changes (we can do the short term, albeit imperfectly). No one. Not you, not Eliezer, not Sam Altman, and not your next door neighbor. How well did people predict the final impacts of the printing press? How well did people predict the final impacts of fire? We even have an expression “playing with fire.” Yet it is, on net, a good thing we proceeded with the deployment of fire (“Fire? You can’t do that! Everything will burn! You can kill people with fire! All of them! What if someone yells “fire” in a crowded theater!?”). Therefore, it’ll be fine: I am a bit distressed each time I read an account of a person “arguing himself” or “arguing herself” into existential risk from AI being a major concern. No one can foresee those futures! Once you keep up the arguing, you also are talking yourself into an illusion of predictability. Since it is easier to destroy than create, once you start considering the future in a tabula rasa way, the longer you talk about it, the more pessimistic you will become. It will be harder and harder to see how everything hangs together, whereas the argument that destruction is imminent is easy by comparison. The case for destruction is so much more readily articulable — “boom!” Yet at some point your inner Hayekian (Popperian?) has to take over and pull you away from those concerns. (Especially when you hear a nine-part argument based upon eight new conceptual categories that were first discussed on LessWrong eleven years ago.) Existential risk from AI is indeed a distant possibility, just like every other future you might be trying to imagine. All the possibilities are distant, I cannot stress that enough. The mere fact that AGI risk can be put on a par with those other also distant possibilities simply should not impress you very much. So we should take the plunge. If someone is obsessively arguing about the details of AI technology today, and the arguments on LessWrong from eleven years ago, they won’t see this. Don’t be suckered into taking their bait. Look. It may well be fine. I said before my chance of existential risk from AI is 33%; that means I think there’s a 66% chance it won’t happen. In most futures, we get through okay, and Tyler gently ribs me for being silly. Don’t let him. Even if AI is the best thing that ever happens and never does anything wrong and from this point forward never even shows racial bias or hallucinates another citation ever again, I will stick to my position that the Safe Uncertainty Fallacy is a bad argument. Normally this would be the point where I try to steelman Tyler and explain in more detail why the strongest version of his case is wrong. But I’m having trouble figuring out what the strong version is. Here are three possibilities: 1) The base rate for things killing humanity is very low, so we would need a strong affirmative argument to shift our estimate away from that base rate. Since there’s so much uncertainty, we don’t have strong affirmative arguments, and we should stick with our base rate of “very low”. Suppose astronomers spotted a 100-mile long alien starship approaching Earth. Surely this counts as a radically uncertain situation if anything does; we have absolutely no idea what could happen. Therefore - the alien starship definitely won’t kill us and it’s not worth worrying? Seems wrong. What’s the base rate for alien starships approaching Earth killing humanity? We don’t have a base rate, because we’ve never been in this situation before. What is the base rate for developing above-human-level AI killing humanity? We don’t . . . you get the picture. You can try to fish for something sort of like a base rate: “There have been a hundred major inventions since agriculture, and none of them killed humanity, so the base rate for major inventions killing everyone is about 0%”. But I can counterargue: “There have been about a dozen times a sapient species has created a more intelligent successor species: australopithecus → homo habilis, homo habilis → homo erectus, etc - and in each case, the successor species has wiped out its predecessor. So the base rate for more intelligent successor species killing everyone is about 100%”. The Less Wrongers call this game “reference class tennis”, and insist that the only winning move is not to play. Thinking about this question in terms of base rates is just as hard as thinking of it any other way, and would require arguments for why one base rate is better than another. Tyler hasn’t made any. 2) There are so many different possibilities - let’s say 100! - and dying is only one of them, so there’s only a 1% chance that we’ll die. This is sort of how I interpret: Existential risk from AI is indeed a distant possibility, just like every other future you might be trying to imagine. All the possibilities are distant, I cannot stress that enough. The mere fact that AGI risk can be put on a par with those other also distant possibilities simply should not impress you very much. Alien time again! Here are some possible ways the hundred-mile long starship situation could end: The aliens are peaceful and want to share their advanced technology
Inline links: https://substackcdn.com/image/fetch/$s_!jYyh!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F672bd8f5-484b-48ff-a80f-539d7b77b66c_599x238.png, sort of qualifies as an AGI, tries his hand at this argument
Populist movement1 mentions across 1 issues

Populist movement is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between August 12, 2025 and August 12, 2025. The archive places it in contexts such as "the Populist movement in America was strongest right BEFORE the upswing began". It most often appears alongside All Who Go Not Return, Amica Terra, Amish.

Reference entry
Populist movement
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1
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1
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August 12, 2025
Last seen
August 12, 2025
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Highlights From The Comments On Liberalism And Communities
August 12, 2025 · Original source
We ended the Gilded Age fractured and alone, and built up civic associational life, communitarian ideals, etc. from around 1900 to around 1960, after which all those indicators start plunging in all the charts you see everywhere today. But because we have been so focused on the last 60-odd years of data, we have missed the incredibly important context of the (titular) upswing that occurred in the first half of the 20th century in America and didn't require populism (in fact, the Populist movement in America was strongest right BEFORE the upswing began, ~1870-1900), and it was the Progressives that kicked off associational, communitarian ideals. This increase in community and togetherness was a strong trend through the Great Depression, the New Deal, and the Postwar years. It wasn't costless! There were reasons people rebelled against the reigning order in the 1960s and 1970s. But every solution creates its own problems, and I think making this about Modernity and not about the last 65 years of culture obscures the contours of the issue.
porn1 mentions across 1 issues

porn is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between January 04, 2024 and January 04, 2024. The archive places it in contexts such as "people would spend whatever money they now spend on Instacart on something else (let’s say booze and porn)". It most often appears alongside ACX Grants, America, booze.

Reference entry
porn
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1
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1
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January 04, 2024
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January 04, 2024
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Does Capitalism Beat Charity?
January 04, 2024 · Original source
Job creation: Along with helping its customers, Instacart employs 10,000 full-time employees and 600,000 gig workers, so our $1 million investment might produce a few dozen jobs. That still doesn’t seem to counterbalance the advantage of Charity. But also (and I admit I have trouble thinking about this), it doesn’t seem obvious that Instacart “causes” jobs. Suppose Instacart had never been founded. Then people would spend whatever money they now spend on Instacart on something else (let’s say booze and porn), which would also create jobs (for brewers, bartenders, and porn stars). There’s no particular reason to think spending the money on Instacart creates more jobs than spending it on those other things would. So how many jobs does Instacart create over replacement? I’m not sure but I think it must be much less than the official number of employees.
Portuguese press1 mentions across 1 issues

Portuguese press is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between October 01, 2025 and October 01, 2025. The archive places it in contexts such as "the Portuguese press of the time was quite liberal". It most often appears alongside 1910s Portugal, 1999 British eclipse, 2017 US eclipse.

Reference entry
Portuguese press
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1
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1
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October 01, 2025
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October 01, 2025
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The Fatima Sun Miracle: Much More Than You Wanted To Know
October 01, 2025 · Original source
Is there some competing form of cherry-picking, where only the positive ones survived and made it to authorities? I’m not sure. There were many unbelievers in the crowd who would have been happy to mock the miracle, and the Portuguese press of the time was quite liberal and would have been happy to publish debunkings. Indeed, several newspapers published articles of the form “This is probably a natural phenomenon, even if we’re not quite sure which one, and people should stop freaking out about it”. I find it hard to believe that the incentives that generated those articles would not have also encouraged negative witnesses to come forward, if they existed. But we have only the examples above.
Poseidon1 mentions across 1 issues

Poseidon is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between October 04, 2021 and October 04, 2021. The archive places it in contexts such as "larger-than-life statue of Poseidon in the form of a merman". It most often appears alongside 19th century African art, 20th century, 9-11.

Reference entry
Poseidon
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1
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1
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October 04, 2021
Last seen
October 04, 2021
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Highlights From The Comments On Modern Architecture
October 04, 2021 · Original source
I mentioned that last anecdote to the art teacher in my high school, and was surprised to get a fairly enthusiastic response to the effect that yes, there is a raging controversy over whether art should be beautiful, and if not, whether beautiful art should even be allowed. She directed me to a recent story, clipped and posted to her bulletin board, about a city which had arranged for a public art project, seen the proposal somehow come in as a larger-than-life statue of Poseidon in the form of a merman holding the reins of five orcas, canceled the project because *that's just not the sort of thing we do*, and run into the absolutely unprecedented problem of massive public support for the public art project they wanted to cancel.
Inline links: a recent story
positron emission tomography1 mentions across 1 issues

positron emission tomography is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between July 16, 2024 and July 16, 2024. The archive places it in contexts such as "millimeter-scale spatial resolution of simultaneous fMRI and positron emission tomography (PET)". It most often appears alongside auditory cortex, Big Bang, cerebellum.

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1
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1
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July 16, 2024
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July 16, 2024
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Consciousness As Recursive Reflections
July 16, 2024 · Original source
There is another new approach that also improves the intersection of spatial and temporal resolution. It combines the millimeter-scale spatial resolution of simultaneous fMRI and positron emission tomography (PET, that’s the one where you inject a radioactive tracer) with improvements of temporal resolution down to as little as 12 seconds using clever tweaks to radiotracer delivery. Currently that temporal resolution is still too long for most thoughts, but there’s ongoing development and the physical limits to improving the temporal resolution of this method are not yet established. This might end up superior to EEG source analysis, especially for studying the center of the brain.
Inline links: temporal resolution down to as little as 12 seconds
post civil war progressives1 mentions across 1 issues

post civil war progressives is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between August 08, 2024 and August 08, 2024. The archive places it in contexts such as ""hybrid" moral systems from a Nietzschean POV (Puritans, early Soviets, post civil war progressives, Yglesias ... )". It most often appears alongside 10240, 4chan, @slatestarcodex.

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1
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1
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August 08, 2024
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August 08, 2024
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Highlights From The Comments On Nietzsche
August 08, 2024 · Original source
Nietzsche has good psychological insight, but I think that he offers a distorted perspective for analyzing social morality. What you see as "hybrid" moral systems from a Nietzschean POV (Puritans, early Soviets, post civil war progressives, Yglesias ... ) are pretty typical in their merger of embiggening and ensmalling virtues. My guess is that only sick, disordered societies are dominated by either slave or master moralities (obviously, most societies have have had both b/c it's hard to be a slave w/o a master or vice versa).
post-Christian vitalist1 mentions across 1 issues

post-Christian vitalist is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between January 23, 2025 and January 23, 2025. The archive places it in contexts such as "I don’t think anyone is, deep down, a based post-Christian vitalist". It most often appears alongside Bedari, Britain, Nietzschean.

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Everyone's A Based Post-Christian Vitalist Until The Grooming Gangs Show Up
January 23, 2025 · Original source
Whenever I talk about charity, a type that I’ll call the “based post-Christian vitalist” shows up in the comments to tell me that I’ve got it all wrong. The moral impulse tells us to help our family, friends, and maybe village. It’s a weird misfire, analogous to an auto-immune disease, to waste brain cycles on starving children in a far-off country who you’ll never meet. You’ve been cucked by centuries of Christian propaganda. Instead of the slave morality that yokes you to loser victims who wouldn’t give you the time of day if your situations were reversed, you should cultivate a master morality that lets you love the strong people who push forward human civilization.
A younger and more naive person might think the based post-Christian vitalist and I have some irreconcilable moral difference. Moral argument can only determine which conclusions follow from certain premises. If premises are too different (for example, a intuitive feeling of compassion for others, vs. an intuitive feeling of strength and pitilessness), there’s no way to proceed.
Inline links: irreconcilable moral difference
I don’t think anyone is, deep down, a based post-Christian vitalist. It’s fun to LARP as the Nietzschean superman, but ask Raskolnikov how far that gets you. I think we all have the same basic moral impulses, and that for most people - including most people who deny it - those potentially include caring about poor people you’ll never meet, suffering in far-off countries.
Post-COVID Learning Recovery1 mentions across 1 issues

Post-COVID Learning Recovery is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between March 10, 2025 and March 10, 2025. The archive places it in contexts such as "New NAEP Scores Dash Hope Of Post-COVID Learning Recovery". It most often appears alongside NAEP.

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March 10, 2025
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  • NAEP 1 shared issues
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What Happened To NAEP Scores?
March 10, 2025 · Original source
Most headlines have said something like New NAEP Scores Dash Hope Of Post-COVID Learning Recovery, which seems like a fair assessment.
Inline links: New NAEP Scores Dash Hope Of Post-COVID Learning Recovery
post-exertional malaise1 mentions across 1 issues

post-exertional malaise is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between August 05, 2022 and August 05, 2022. The archive places it in contexts such as "what we now call post-exertional malaise". It most often appears alongside acedia, Against Nature, Anna Schaffner.

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Your Book Review: Exhaustion
August 05, 2022 · Original source
So here we see one of the first accounts of one of the hallmark symptoms of CFS, what we now call post-exertional malaise. You do something to break the monotony of rest, but after exerting yourself you feel significantly worse.
post-Floyd panopticon society1 mentions across 1 issues

post-Floyd panopticon society is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between December 10, 2024 and December 10, 2024. The archive places it in contexts such as "but also has much greater reputational risk in our post-Floyd panopticon society". It most often appears alongside ACT, AI, America.

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Highlights From The Comments On Prison
December 10, 2024 · Original source
I’m not an expert but PB’s argument looks sound to me. It also makes sense - he writes “Look at the choices - sit in a nice air conditioned car for 80% of your time, interacting with the soccer moms and nice middle and upper class people you pull over, OR be out in the bad parts of downtown interacting with volatile psychos, shambling fentanyl zombies, and schizophrenic homeless people? Oh, plus writing tickets generates revenue for the city, and doing anything to prevent or investigate actual crime has you interacting with all the psychos and zombies. They are doing easy things because they are easy, and because doing hard things is not only hard in and of itself, but also has much greater reputational risk in our post-Floyd panopticon society.”
Post-partum depression1 mentions across 1 issues

Post-partum depression is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between March 08, 2022 and March 08, 2022. The archive places it in contexts such as "Post-partum depression is one of the rarer psych conditions". It most often appears alongside alcohol, allopregnanolone, allopregnanolone.

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Post-partum depression
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Zounds! It's Zulresso and Zuranolone!
March 08, 2022 · Original source
Zulresso is the brand name of allopregnanolone (aka brexanolone), a new medication for post-partum depression. It’s interesting as a potential missing link between hormones and normal mood regulation.
History of allopregnanolone research (source) The next step was to see if making patients take allopregnanolone can treat these conditions. This is kind of hard, because allopregnanolone is a tough chemical to get into people’s bodies; the traditional method involves sticking an IV into someone and infusing it slowly over several days, and it has to be done in a hospital. Still, Kanes et al tried this in 2017. The study was open-label (ie no placebo) and very small (only four women) but appeared to work extraordinarily well. Four post-partum women who qualified as “severely depressed” when they started the infusion progressed to “completely recovered” within twelve hours. Nothing else except maybe ketamine had produced results like this before. 3: What studies were done on Zulresso? This followup study by Kanes was the first real RCT, although it only had 21 patients. In accordance with the venerable First Study Ever tradition, it found really large positive effects on post-partum depression. That encouraged Sage Therapeutics to fund a bigger Phase 3 trial, Meltzer-Brody (2018). In accordance with venerable Bigger Phase 3 Trial tradition, its results weren’t quite as good as the First Study Ever. But they were still pretty good: Notice that lower doses worked better than higher doses. This is sometimes a red flag on a study. But this time it seems legit; see “Biphasic Actions At The GABA-A Receptor” here for an explanation. Both studies also evaluated side effects. These were generally mild, but two people (about 2% of the study population) lost consciousness. Nothing seemed wrong with them, and researchers mostly attributed this to allopregnanolone being a sedating drug. If you sedate people too hard, they pass out. Faced with these results, the FDA approved allopregnanolone for post-partum depression, but subjected it to a REMS (Risk Evaluation And Mitigation Strategy) - basically, doctors who want to prescribe it will need to take special courses and do extra paperwork. This kind of surprised me - there are plenty of sedating drugs that make you pass out in overdose. Also, since patients will be getting it IV, there will probably be a nurse around to check if they passed out and take appropriate actions if so. But the FDA really likes putting restrictions on things, and I guess this was a free chance for them to do that. 4: Is Zulresso freely available at a doctor’s office near me? It’s possible to get Zulresso, but really hard. Because Zulresso is an IV infusion lasting four days, you need to spend four days somewhere that people can put an IV into you and monitor it. Realistically that means a hospital or some other big medical institution. So this is only available for inpatients. Because of the REMS (extra certification and paperwork), most hospitals aren’t interested. You can find a list of ones that are here - it looks like there are about 89 locations in the US with the right certification. Last but not least, a four-day course of Zulresso costs $35,000 for the medication itself, plus much more for the four-day hospitalization it takes to receive it. As usual, insurances will cover it iff you can document you’ve tried lots of other stuff first. 5: Hold on, does it really cost $35,000? Oho, I see you’ve played the “pharma price analysis” game before. But this time I think the price might actually be defensible. Chemical supply companies (1, 2, 3) generally sell allopregnanolone for $10,000 to $20,000 a gram. (I found one company with a much lower price, but I’m suspicious and am going to dismiss them as an outlier). The usual dose of allopregnanolone is 60 ug/kg/hour x 60 hours, which for a 60 kg person comes out to a total of 0.25g total. Getting that amount from the chemistry supply store would cost about $2,500 - 5,000. I assume pharma-grade allopregnanolone is more expensive than chemistry-store-grade, so it wouldn’t surprise me if a price in the low five-figures was justified by manufacturing alone. Isn’t it still a pretty good deal to find an endogenous neurosteroid, do one or two studies confirming it’s great, produce it for the low five figures, then sell it for the mid five figures? I think maybe not. This drug has a terrible value proposition. Post-partum depression is one of the rarer psych conditions. Most people with PPD won’t check into a hospital and pay $35,000 for a drug infusion. And the people who do will get the drug infusion, feel better, and never need it again (at least until they have another kid) - unlike SSRIs where you can keep charging for monthly prescriptions forever. Sage Therapeutics, the pharma company that owns the patent on Zulresso (and nothing else - this is their only drug!) has done terribly. Their stock is in the doldrums, they almost went bankrupt, and they survived only with the help of a cash infusion by a bigger pharma company. I think this confirms a general trend where at least some expensive medications are pricey because of fundamentals (including regulatory fundamentals) and not just pharma companies making obscene profits. 6: Hold on, how is allopregnanolone different from benzodiazepines? Remember, allopregnanolone is a positive allosteric modulator of GABA, much like benzodiazepines such as Xanax. But Xanax is cheap ($10 for 30 pills). And you can get it at any local pharmacy (plus sometimes on street corners). What’s so special about allopregnanolone that you should pay $35,000 and go into the hospital to get it? The official answer is “allopregnanolone modulates GABA differently from benzodiazepines”. For example, this paper says that: Allopregnanolone allosteric modulation of the action of GABA at GABA-A receptors is much less selective than that of benzodiazepines, which are relatively inactive at α4- or α6-containing GABA-A receptors. If you really like details about receptor subunits, this paper presents the full case. The skeptic’s answer is “who knows?” Psych drugs often work for reasons totally different than we thought. People thought tianeptine was an SSRE for years, until it turned out to be a mild opioid. People thought ketamine was NMDA-ergic for years, until it turned out to be [fill this part in 10 years from now]. Last year a bunch of very smart people tried to claim that SSRI effects had nothing to do with serotonin (I think they were wrong). Just because some guy found that Zulresso acts as a GABA-PAM in some test tube doesn’t mean that’s what’s having any of the relevant antidepressant effects. The troll’s answer is “who says it’s different?” Do benzodiazepines treat depression? Depends who you ask. If you ask benzodiazepine users, their answer is “yes, definitely”. If you ask drug warriors, their answer is “Addictive Substances May Make You Temporarily Feel Good, But They Are Not A Responsible Treatment Option”. If you ask the research literature, it gives vague indeterminate answers, as always. But nobody has ever said benzodiazepines instantly and miraculously cure depression, so how come allopregnanolone seems to do that? A true troll would point out that we probably give allopregnanolone at much higher doses - 2% of allopregnanolone patients were sedated so hard they lost consciousness, whereas this is exactly the sort of side effect I try to avoid when calculating benzodiazepine doses. Maybe if you gave postpartum women an infusion of 300 mg Valium, and maximized your placebo effect by calling it the hot new thing, they’d do pretty well too (several days later, after recovering consciousness). I think the troll answer would be hilarious but I don’t really want to defend it as correct; if I had to bet I’d say the official explanation is the right one. 7: Hold on, why can’t we just give people progesterone and let them metabolize it into allopregnanolone? This turned out to be an interesting enough rabbit hole that I’m going to spin it off into another post later this week. 8: Hold on, people have lots of allopregnanolone when they’re pregnant, right? And then post-partum depression happens when they give birth, and their allopregnanolone level drops. So if you give someone an infusion of allopregnanolone, and then take them off it, that’s a hormonal simulation of giving birth, ie the same thing that caused the problem in the first place? How is that good? Oh, you think you’re clever, do you? What you failed to consider is . . . I didn’t end that sentence because I can’t find anything in the literature addressing this question. But the difference might be that the infusion schedule ramps up gradually, peaks, and then ramps down gradually, which is more of a soft taper than the sudden crash of birth. If anyone knows more about this, please let me know. [EDIT: see this comment] 9: Is allopregnanolone addictive? No, because good luck getting addicted to a $35,000-per-dose chemical. We should probably expect allopregnanolone to be addictive, by analogy to other GABA-PAMs like benzodiazepines and alcohol. But nobody has ever received more than a single dose. You don’t get addicted to benzos after a single pill, or alcohol after a single beer, so in practice AFAIK nobody has ever gotten addicted to this. Or who knows, maybe it’s not addictive. Remember, allopregnanolone is naturally elevated during pregnancy; pregnancy isn’t addictive. And some scientists claim the brain endogenously uses allopregnanolone as a master regulator of depression and anxiety. In theory, if you could give yourself the same amount a non-anxious person’s brain gives them all the time, shouldn’t you be no worse off than that non-anxious person? I don’t know, and remember that your brain also has a lot of endogenous opioids; doesn’t make the exogenous kind any safer. The Drug Enforcement Administration has made Zulresso a Schedule IV controlled substance, which means they’re putting a few very weak restrictions on it but not worrying too much. 10: Does allopregnanolone work for depression that isn’t post-partum? If all psychiatric disorders are secretly allopregnanolone imbalances, then you might expect it to work on all depressions, not just post-partum. I’m sure pharmaceutical executives with dollar signs instead of pupils in their eyes have had this same thought, but I can’t find studies about it. Some of the same people behind the postpartum studies did a very small, very weak study on ganaloxone (a close allopregnanolone relative) for persistent depression; it seemed to work, but also caused a lot of sedation (more than in the postpartum trials? Hard to tell). Nobody’s looked into this further since then, maybe because that was around when the pharma companies realized that the 4-day hospital stay and $35,000 price tag made allopregnanolone a financial loser. The evidence from zuranolone (see below) suggests that allopregnanolone might not work very well against regular depression. 11: What is zuranolone? Wikipedia describes zuranolone as “a swirling, black vortex revered by the Mutsune Native Americans as a dire death god . . . also worshiped by mysterious servitors known as the Hidden Ones.” No! Sorry again! That’s Zushakon, another Great Old One. Zuranolone is Sage Therapeutics’ attempt to turn allopregnanolone into an accessible medication that might actually make them real money. Zuranolone is mostly just allopregnanolone with some extra stuff attached that changes the absorption. Zuranolone can be taken orally, so you don’t have to go to a hospital for four days to receive it IV. It’s potentially less likely to cause loss of consciousness and other undesirable side effects. And it’s under investigation as a potential treatment for postpartum depression, bipolar depression, regular depression, insomnia, and various movement disorders. (that might seem excessive, but benzodiazepines treat a lot of stuff, and if these neurosteroids are kind of like super-benzodiazepines, then this level of optimism might be warranted.) 12: Does zuranolone work? Sage Therapeutics answered this question the same way pharma companies answer every question: with a bunch of studies whose names form overly-cute acronyms. We’ll talk here about ROBIN, WATERFALL, MOUNTAIN, and CORAL - though I assure you there are others. ROBIN tested efficacy in postpartum depression. Results were positive and relatively impressive, about the same as the weaker allopregnanolone studies. WATERFALL, MOUNTAIN, and CORAL tested results in regular depression. WATERFALL was positive but weak. MOUNTAIN was negative. That scared the pharma company and they hacked CORAL to be more likely to give positive results. It did give positive results, but the FDA reads the same biotech magazines I do and knows perfectly well what they did, so I don’t know what Sage expects to gain from this. Overall these trials were disappointing. I think the most likely story is that allopregnanolone = zuranolone, both are moderately effective in postpartum depression, and both have much less efficacy in regular depression, probably not literally zero but also not enough to be worthwhile antidepressants (especially considering cost). Might zuranolone be an excellent anti-anxiety medication? You’d think so - it should be at least as good as benzodiazepines, which are excellent anti-anxiety medications. And researchers seem excited about allopregnanolone as a master regulator of brain anxiety. But the studies aren’t promising. ROBIN and WATERFALL incidentally assessed anxiety; ROBIN found good results in its postpartum population, but WATERFALL found poor-to-mediocre results in its regular population. Studies are hard, and sometimes even really effective drugs can have trouble showing strong results. But these aren’t encouraging. 13: So where do we go from here? Getting FDA approval for zuranolone for postpartum depression seems reasonable; it’ll probably be cheaper and easier than making people go to the hospital to get allopregnanolone. I’m uncertain about the financials of this for Sage, but since they did the study they hopefully think it’s worth it. Otherwise, I’m not sure. It would have been great if zuranolone had shown robust efficacy against regular depression and anxiety, but this is exactly the kind of great thing that never happens in psychopharmacology (motto: “Disappointing Doctors And Patients Since 1982”). It might be worth throwing it against anxiety disorders and PTSD to see if anything sticks, but I wouldn’t bet on it. The research into allopregnanolone as master regulator of brain anxiety states is fascinating, but as far as I know it hasn’t reckoned with the failure of zuranolone to really treat much anxiety. The cynical part of me predicts that once pharma’s done making money off neurosteroids then all of this will die down, and something else that pharma can make more money from will become the master regulator of everything. I expect that the main thing we get out of all this is somewhat better post-partum depression treatment, which might or might not ever become accessible for ordinary people. 14: Predictions In the next five years… Zuranolone gets FDA approval for major depression: 15%
Inline links: source, Kanes et al, This followup study by Kanes, https://substackcdn.com/image/fetch/$s_!3b3x!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F63f81091-7084-4ad3-b0a3-28394059b2c3_369x282.png, Meltzer-Brody (2018), https://substackcdn.com/image/fetch/$s_!l7Uh!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F2b579fea-c6c8-4d46-8de7-c4a3e6852766_797x335.png, here, here, 1, 2, one company, has done terribly, this paper, this paper, tried to claim, their answer is, their answer is, it gives vague indeterminate answers, this comment, a very small, very weak study, describes, https://substackcdn.com/image/fetch/$s_!hqfF!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F5b386f78-93b3-4d16-98c4-6d2eedef5a1f_548x256.png, ROBIN, WATERFALL, MOUNTAIN, CORAL, to be more likely to give positive results
Notice that lower doses worked better than higher doses. This is sometimes a red flag on a study. But this time it seems legit; see “Biphasic Actions At The GABA-A Receptor” here for an explanation. Both studies also evaluated side effects. These were generally mild, but two people (about 2% of the study population) lost consciousness. Nothing seemed wrong with them, and researchers mostly attributed this to allopregnanolone being a sedating drug. If you sedate people too hard, they pass out. Faced with these results, the FDA approved allopregnanolone for post-partum depression, but subjected it to a REMS (Risk Evaluation And Mitigation Strategy) - basically, doctors who want to prescribe it will need to take special courses and do extra paperwork. This kind of surprised me - there are plenty of sedating drugs that make you pass out in overdose. Also, since patients will be getting it IV, there will probably be a nurse around to check if they passed out and take appropriate actions if so. But the FDA really likes putting restrictions on things, and I guess this was a free chance for them to do that. 4: Is Zulresso freely available at a doctor’s office near me? It’s possible to get Zulresso, but really hard. Because Zulresso is an IV infusion lasting four days, you need to spend four days somewhere that people can put an IV into you and monitor it. Realistically that means a hospital or some other big medical institution. So this is only available for inpatients. Because of the REMS (extra certification and paperwork), most hospitals aren’t interested. You can find a list of ones that are here - it looks like there are about 89 locations in the US with the right certification. Last but not least, a four-day course of Zulresso costs $35,000 for the medication itself, plus much more for the four-day hospitalization it takes to receive it. As usual, insurances will cover it iff you can document you’ve tried lots of other stuff first. 5: Hold on, does it really cost $35,000? Oho, I see you’ve played the “pharma price analysis” game before. But this time I think the price might actually be defensible. Chemical supply companies (1, 2, 3) generally sell allopregnanolone for $10,000 to $20,000 a gram. (I found one company with a much lower price, but I’m suspicious and am going to dismiss them as an outlier). The usual dose of allopregnanolone is 60 ug/kg/hour x 60 hours, which for a 60 kg person comes out to a total of 0.25g total. Getting that amount from the chemistry supply store would cost about $2,500 - 5,000. I assume pharma-grade allopregnanolone is more expensive than chemistry-store-grade, so it wouldn’t surprise me if a price in the low five-figures was justified by manufacturing alone. Isn’t it still a pretty good deal to find an endogenous neurosteroid, do one or two studies confirming it’s great, produce it for the low five figures, then sell it for the mid five figures? I think maybe not. This drug has a terrible value proposition. Post-partum depression is one of the rarer psych conditions. Most people with PPD won’t check into a hospital and pay $35,000 for a drug infusion. And the people who do will get the drug infusion, feel better, and never need it again (at least until they have another kid) - unlike SSRIs where you can keep charging for monthly prescriptions forever. Sage Therapeutics, the pharma company that owns the patent on Zulresso (and nothing else - this is their only drug!) has done terribly. Their stock is in the doldrums, they almost went bankrupt, and they survived only with the help of a cash infusion by a bigger pharma company. I think this confirms a general trend where at least some expensive medications are pricey because of fundamentals (including regulatory fundamentals) and not just pharma companies making obscene profits. 6: Hold on, how is allopregnanolone different from benzodiazepines? Remember, allopregnanolone is a positive allosteric modulator of GABA, much like benzodiazepines such as Xanax. But Xanax is cheap ($10 for 30 pills). And you can get it at any local pharmacy (plus sometimes on street corners). What’s so special about allopregnanolone that you should pay $35,000 and go into the hospital to get it? The official answer is “allopregnanolone modulates GABA differently from benzodiazepines”. For example, this paper says that: Allopregnanolone allosteric modulation of the action of GABA at GABA-A receptors is much less selective than that of benzodiazepines, which are relatively inactive at α4- or α6-containing GABA-A receptors. If you really like details about receptor subunits, this paper presents the full case. The skeptic’s answer is “who knows?” Psych drugs often work for reasons totally different than we thought. People thought tianeptine was an SSRE for years, until it turned out to be a mild opioid. People thought ketamine was NMDA-ergic for years, until it turned out to be [fill this part in 10 years from now]. Last year a bunch of very smart people tried to claim that SSRI effects had nothing to do with serotonin (I think they were wrong). Just because some guy found that Zulresso acts as a GABA-PAM in some test tube doesn’t mean that’s what’s having any of the relevant antidepressant effects. The troll’s answer is “who says it’s different?” Do benzodiazepines treat depression? Depends who you ask. If you ask benzodiazepine users, their answer is “yes, definitely”. If you ask drug warriors, their answer is “Addictive Substances May Make You Temporarily Feel Good, But They Are Not A Responsible Treatment Option”. If you ask the research literature, it gives vague indeterminate answers, as always. But nobody has ever said benzodiazepines instantly and miraculously cure depression, so how come allopregnanolone seems to do that? A true troll would point out that we probably give allopregnanolone at much higher doses - 2% of allopregnanolone patients were sedated so hard they lost consciousness, whereas this is exactly the sort of side effect I try to avoid when calculating benzodiazepine doses. Maybe if you gave postpartum women an infusion of 300 mg Valium, and maximized your placebo effect by calling it the hot new thing, they’d do pretty well too (several days later, after recovering consciousness). I think the troll answer would be hilarious but I don’t really want to defend it as correct; if I had to bet I’d say the official explanation is the right one. 7: Hold on, why can’t we just give people progesterone and let them metabolize it into allopregnanolone? This turned out to be an interesting enough rabbit hole that I’m going to spin it off into another post later this week. 8: Hold on, people have lots of allopregnanolone when they’re pregnant, right? And then post-partum depression happens when they give birth, and their allopregnanolone level drops. So if you give someone an infusion of allopregnanolone, and then take them off it, that’s a hormonal simulation of giving birth, ie the same thing that caused the problem in the first place? How is that good? Oh, you think you’re clever, do you? What you failed to consider is . . . I didn’t end that sentence because I can’t find anything in the literature addressing this question. But the difference might be that the infusion schedule ramps up gradually, peaks, and then ramps down gradually, which is more of a soft taper than the sudden crash of birth. If anyone knows more about this, please let me know. [EDIT: see this comment] 9: Is allopregnanolone addictive? No, because good luck getting addicted to a $35,000-per-dose chemical. We should probably expect allopregnanolone to be addictive, by analogy to other GABA-PAMs like benzodiazepines and alcohol. But nobody has ever received more than a single dose. You don’t get addicted to benzos after a single pill, or alcohol after a single beer, so in practice AFAIK nobody has ever gotten addicted to this. Or who knows, maybe it’s not addictive. Remember, allopregnanolone is naturally elevated during pregnancy; pregnancy isn’t addictive. And some scientists claim the brain endogenously uses allopregnanolone as a master regulator of depression and anxiety. In theory, if you could give yourself the same amount a non-anxious person’s brain gives them all the time, shouldn’t you be no worse off than that non-anxious person? I don’t know, and remember that your brain also has a lot of endogenous opioids; doesn’t make the exogenous kind any safer. The Drug Enforcement Administration has made Zulresso a Schedule IV controlled substance, which means they’re putting a few very weak restrictions on it but not worrying too much. 10: Does allopregnanolone work for depression that isn’t post-partum? If all psychiatric disorders are secretly allopregnanolone imbalances, then you might expect it to work on all depressions, not just post-partum. I’m sure pharmaceutical executives with dollar signs instead of pupils in their eyes have had this same thought, but I can’t find studies about it. Some of the same people behind the postpartum studies did a very small, very weak study on ganaloxone (a close allopregnanolone relative) for persistent depression; it seemed to work, but also caused a lot of sedation (more than in the postpartum trials? Hard to tell). Nobody’s looked into this further since then, maybe because that was around when the pharma companies realized that the 4-day hospital stay and $35,000 price tag made allopregnanolone a financial loser. The evidence from zuranolone (see below) suggests that allopregnanolone might not work very well against regular depression. 11: What is zuranolone? Wikipedia describes zuranolone as “a swirling, black vortex revered by the Mutsune Native Americans as a dire death god . . . also worshiped by mysterious servitors known as the Hidden Ones.” No! Sorry again! That’s Zushakon, another Great Old One. Zuranolone is Sage Therapeutics’ attempt to turn allopregnanolone into an accessible medication that might actually make them real money. Zuranolone is mostly just allopregnanolone with some extra stuff attached that changes the absorption. Zuranolone can be taken orally, so you don’t have to go to a hospital for four days to receive it IV. It’s potentially less likely to cause loss of consciousness and other undesirable side effects. And it’s under investigation as a potential treatment for postpartum depression, bipolar depression, regular depression, insomnia, and various movement disorders. (that might seem excessive, but benzodiazepines treat a lot of stuff, and if these neurosteroids are kind of like super-benzodiazepines, then this level of optimism might be warranted.) 12: Does zuranolone work? Sage Therapeutics answered this question the same way pharma companies answer every question: with a bunch of studies whose names form overly-cute acronyms. We’ll talk here about ROBIN, WATERFALL, MOUNTAIN, and CORAL - though I assure you there are others. ROBIN tested efficacy in postpartum depression. Results were positive and relatively impressive, about the same as the weaker allopregnanolone studies. WATERFALL, MOUNTAIN, and CORAL tested results in regular depression. WATERFALL was positive but weak. MOUNTAIN was negative. That scared the pharma company and they hacked CORAL to be more likely to give positive results. It did give positive results, but the FDA reads the same biotech magazines I do and knows perfectly well what they did, so I don’t know what Sage expects to gain from this. Overall these trials were disappointing. I think the most likely story is that allopregnanolone = zuranolone, both are moderately effective in postpartum depression, and both have much less efficacy in regular depression, probably not literally zero but also not enough to be worthwhile antidepressants (especially considering cost). Might zuranolone be an excellent anti-anxiety medication? You’d think so - it should be at least as good as benzodiazepines, which are excellent anti-anxiety medications. And researchers seem excited about allopregnanolone as a master regulator of brain anxiety. But the studies aren’t promising. ROBIN and WATERFALL incidentally assessed anxiety; ROBIN found good results in its postpartum population, but WATERFALL found poor-to-mediocre results in its regular population. Studies are hard, and sometimes even really effective drugs can have trouble showing strong results. But these aren’t encouraging. 13: So where do we go from here? Getting FDA approval for zuranolone for postpartum depression seems reasonable; it’ll probably be cheaper and easier than making people go to the hospital to get allopregnanolone. I’m uncertain about the financials of this for Sage, but since they did the study they hopefully think it’s worth it. Otherwise, I’m not sure. It would have been great if zuranolone had shown robust efficacy against regular depression and anxiety, but this is exactly the kind of great thing that never happens in psychopharmacology (motto: “Disappointing Doctors And Patients Since 1982”). It might be worth throwing it against anxiety disorders and PTSD to see if anything sticks, but I wouldn’t bet on it. The research into allopregnanolone as master regulator of brain anxiety states is fascinating, but as far as I know it hasn’t reckoned with the failure of zuranolone to really treat much anxiety. The cynical part of me predicts that once pharma’s done making money off neurosteroids then all of this will die down, and something else that pharma can make more money from will become the master regulator of everything. I expect that the main thing we get out of all this is somewhat better post-partum depression treatment, which might or might not ever become accessible for ordinary people. 14: Predictions In the next five years… Zuranolone gets FDA approval for major depression: 15%
Inline links: here, here, 1, 2, one company, has done terribly, this paper, this paper, tried to claim, their answer is, their answer is, it gives vague indeterminate answers, this comment, a very small, very weak study, describes, https://substackcdn.com/image/fetch/$s_!hqfF!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F5b386f78-93b3-4d16-98c4-6d2eedef5a1f_548x256.png, ROBIN, WATERFALL, MOUNTAIN, CORAL, to be more likely to give positive results
Post-postmodernism1 mentions across 1 issues

Post-postmodernism is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between September 06, 2024 and September 06, 2024. The archive places it in contexts such as "Post-postmodernism After I left the radical left, it was hard to find anything to believe in". It most often appears alongside #MeToo, 21st century political dogmatism, Advanced Tax.

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Your Book Review: The Pale King
September 06, 2024 · Original source
He believed contemporary fiction was stuck in two modes: cheap entertainment, or grim jeremiad. “Look, man, we’d probably most of us agree that these are dark times, and stupid ones, but do we need fiction that does nothing but dramatize how dark and stupid everything is?” He aimed to inspire a vision of another way of living, both with others and within our own minds. His third novel, the “Long Thing,” which eventually came to be titled The Pale King, was meant to be an articulation of that vision. Post-postmodernism After I left the radical left, it was hard to find anything to believe in. The rightists were refreshingly frank, but dealt with postmodernism mainly by strawmanning it, ignoring its strongest points and asserting the naivest of realisms. Besides, their ideas were ugly and brutal. Religion offered another path, but again, it felt like mere reaction—giving up on synthesis and bowing out of the intellectual conversation altogether.
post-Roman writings1 mentions across 1 issues

post-Roman writings is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between May 06, 2021 and May 06, 2021. The archive places it in contexts such as "gave a look into the post-Roman writings". It most often appears alongside 320 AD, 476 AD, Africa.

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Your Book Review: Through The Eye Of A Needle
May 06, 2021 · Original source
Obviously, I loved the book. Why else would I have written 5,000 words on it? Brown has a lot of information to share. In this review, I barely got into his main thesis – the entrance of wealth into the western Christian churches of late antiquity. His chapters on the collapse of the Respublica were riveting. I also appreciated that Brown whizzed past the traditional end date of 476 AD and gave a look into the post-Roman writings.
post-singularity charity1 mentions across 1 issues

post-singularity charity is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between January 05, 2026 and January 05, 2026. The archive places it in contexts such as ""post-singularity charity"". It most often appears alongside AGI, AI, Amazon.

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Open Thread 415
January 05, 2026 · Original source
If you don’t put away $25,000, then in order to stay equally well-off you only need for 1% (industrial scale) to 0.0001% (solar scale) of wealth to be redistributed through some combination of private charity and government welfare. Currently about 2% of income is redistributed via charity, and 25% via government (in the US). I glossed this as “you can get a moon in one of Dario Amodei’s galaxies”, and people had strong opinions on that exact example, but many people getting rich in AI have expressed interest in post-singularity charity, and I expect the 0.0001% - 1% target to be reached.
post-Soviet order1 mentions across 1 issues

post-Soviet order is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between February 05, 2026 and February 05, 2026. The archive places it in contexts such as "build intuition for how Russia views the post-Soviet order". It most often appears alongside 4o, 60 Minutes, @MattZeitlin.

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post-Soviet order
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Links For February 2026
February 05, 2026 · Original source
33: Interesting as a way to build intuition for how Russia views the post-Soviet order, h/t @MMJukic
Inline links: @MMJukic
post-soviet system1 mentions across 1 issues

post-soviet system is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between August 11, 2023 and August 11, 2023. The archive places it in contexts such as "post-soviet system of governance". It most often appears alongside 1993 Russian constitutional crisis, 2011 parliamentary election, 2011-2014 protests.

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post-soviet system
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Highlights From The Comments On Putin
August 11, 2023 · Original source
So I think the story is actually much more simple: a smart and capable, but cynical bureaucrat gradually gets corrupted by the absolute power and 23 years of sitting on top of a post-soviet system of governance.
post-truth society1 mentions across 1 issues

post-truth society is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between September 19, 2025 and September 19, 2025. The archive places it in contexts such as "It’s often said that we’re living in a ‘post-truth society’". It most often appears alongside 1987, 1988, Adleman.

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post-truth society
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Your Review: Project Xanadu - The Internet That Might Have Been
September 19, 2025 · Original source
Unlike Doug Engelhart, and unlike Ted Nelson, Tim Berners-Lee never read about Bush’s memex. He built a system that connected people like never before—but made little effort to facilitate the connection of ideas. There are no trails on the World Wide Web—instead, there are misattributed quotes, dead one-way links, constant plagiarism scandals, and widespread misinformation and mutual distrust. It’s often said that we’re living in a ‘post-truth society’. The words we write and videos we share have become entirely unmoored from the ideas underlying them. Strangely, the Web has facilitated more disconnection than was ever possible before.
post-Vietnam syndrome1 mentions across 1 issues

post-Vietnam syndrome is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between July 15, 2021 and July 15, 2021. The archive places it in contexts such as "the original researchers of the condition called it “post-Vietnam syndrome”". It most often appears alongside 1902, 1903, 1906 Japanese neurology journal.

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post-Vietnam syndrome
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Book Review: Crazy Like Us
July 15, 2021 · Original source
In fact, at the very beginning of the emergence of modern PTSD - around the Vietnam War - the original researchers of the condition called it “post-Vietnam syndrome” and tried to define it as a distinctly Vietnamese experience. The idea was that soldiers in past “good” wars had been fighting for something they believed in , had the support of the population back home, and didn’t have psychological problems. Since soldiers in Vietnam were developing all these new symptoms, that was yet more evidence that it was a “bad” war which had to be stopped. Over the course of decades (plus lots of marketing by enthusiastic therapists), PTSD expanded from a Vietnam-only problem, to all wars, to all natural disasters, to abuse and sexual violence, to the modern understanding where people say they got PTSD from a bad boss, a bad roommate, or an insufficiently woke college reading assignment. I enjoyed The Body Keeps The Score partly because it told the other side of this history, from one of the researchers involved in the popularization, who faced roadblocks like “the VA refused to fund studies because they couldn’t see what relevance PTSD might have for veterans”.
Inline links: The Body Keeps The Score
post-Warren-G-Harding liberal order1 mentions across 1 issues

post-Warren-G-Harding liberal order is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between September 25, 2025 and September 25, 2025. The archive places it in contexts such as "furries you get under the post-Warren-G-Harding liberal order". It most often appears alongside Armenians at Harvard, barberpole model of fashion, Baron von Ungern-Sternberg.

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Sources Say Bay Area House Party
September 25, 2025 · Original source
You follow his gaze, and there is Ramchandra, hair greased back, wearing a leather jacket, surrounded by a crowd of young women. “When I say I’m against furries,” he’s explaining, staccato, at 120 wpm, “I mean the sort of captured furries you get under the post-Warren-G-Harding liberal order, the ones getting the fat checks from the Armenians at Harvard and the Department of Energy. I love real furries, the kind you would have found in 1920s New Mexico eating crocodile steaks with Baron von Ungern-Sternberg! Some of my best friends are furries, as de Broglie-Bohm and my sainted mother used to say! Just watch out for the Kikuyu, that’s my advice! Hahahahahaha!” Some of the women are taking notes. “But enough about me. When I was seventeen, I spent seven weeks in Bensonhurst - that’s in the Rotten Apple, in case you can’t tell your Nepalis from your Neapolitans. A dear uncle of mine, after whom I was named…”
postcolonial theory1 mentions across 1 issues

postcolonial theory is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between January 29, 2021 and January 29, 2021. The archive places it in contexts such as "isn't that usually code for stuff like queer theory, postcolonial theory, and postmodernism?". It most often appears alongside 80,000 Hours, AI alignment problem, Anand Giridharadas.

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postcolonial theory
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Contra Weyl On Technocracy
January 29, 2021 · Original source
And would Weyl's suggestions really help prevent populist backlashes? He wishes we abandoned our overly-rational ways in favor of "humanities, Continental philosophy, and the humanistic social sciences" - isn't that usually code for stuff like queer theory, postcolonial theory, and postmodernism? Are working-class Trump supporters really banging on their keyboards when they read about effective altruism, shouting "YOU NEED TO STOP TRYING TO BE OBJECTIVE AND FACT-BASED, AND BE MORE OPEN TO INSIGHTS FROM QUEER THEORY AND POSTMODERNISM"?
Postcolonialists1 mentions across 1 issues

Postcolonialists is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between July 15, 2025 and July 15, 2025. The archive places it in contexts such as "Postcolonialists discovered that all the other anthropologists were racist". It most often appears alongside Aboriginal, Aboriginal Australia, Aboriginal society.

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Postcolonialists
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Book Review: Arguments About Aborigines
July 15, 2025 · Original source
In the early twentieth century, anthropologists embarked on a more ambitious project - demonstrating that something about primitive culture proved that their own political faction was right about everything. Marxists discovered idyllic tribes untouched by capitalism, peacefully sharing their communal resources. Missionaries discovered that every primitive religion was merely a distorted form of Christianity, with a few extra gods and rituals added in to serve local appetites. Feminists discovered that women everywhere developed unique indigenous forms of resistance to patriarchal domination. Postcolonialists discovered that all the other anthropologists were racist. Freudians discovered so many things that it would take ten books of this length to even begin to talk about them.
postmodern architecture1 mentions across 1 issues

postmodern architecture is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between January 08, 2025 and January 08, 2025. The archive places it in contexts such as "In art and architecture, the drive to be “in touch” took the form of ... postmodern architecture". It most often appears alongside #DogeCoin, Alex Tabarrok, Arnold Kling.

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On Priesthoods
January 08, 2025 · Original source
In art and architecture, the drive to be “in touch” took the form of pop art and postmodern architecture, where artists took the materials of normal public life (like Cambpell’s soup cans) and transformed it in some kind of complicated way. The average member of the public might think “Campbell soup! That artist is in touch with my everyday existence!” while also being baffled by layers of ironic reference and artistic flourishes outside his puny little brain’s ability to comprehend. A+ instant classic.
postmodernist1 mentions across 1 issues

postmodernist is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between October 04, 2021 and October 04, 2021. The archive places it in contexts such as "Modernist and postmodernist critics fail to acknowledge". It most often appears alongside 19th century African art, 20th century, 9-11.

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postmodernist
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Highlights From The Comments On Modern Architecture
October 04, 2021 · Original source
Modernist and postmodernist critics fail to acknowledge another feature of human nature that drives the arts: the hunger for status, especially their *own* hunger for status.
postpartum1 mentions across 1 issues

postpartum is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between March 08, 2022 and March 08, 2022. The archive places it in contexts such as "I’m sure pharmaceutical executives with dollar signs instead of pupils in their eyes have had this same thought". It most often appears alongside alcohol, allopregnanolone, allopregnanolone.

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postpartum
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Zounds! It's Zulresso and Zuranolone!
March 08, 2022 · Original source
(source) GABA is the main inhibitory neurotransmitter; it’s usually associated with relaxation and sedation. A positive allosteric modulator is a chemical that makes receptors respond more strongly to their targets. So “a positive allosteric modulator of GABA” means a chemical that makes the brain respond stronger to relaxation/sedation signals. Sounds pretty useful! You may do some positive allosteric modulation of GABA yourself sometimes; this is one of the major actions of alcohol. Also of the benzodiazepines, a popular class of psychiatric medication including Ativan (lorazepam), Valium (diazepam), and Klonopin (clonazepam). The “-pam” at the end stands for positive allosteric modulator! (or maybe that’s just an urban legend, I’ve never found proof either way) The discovery of endorphins (ie endogenous opiates) helped shed light on the brain’s reward system. So the discovery of a sort of endogenous benzodiazepine was pretty exciting. Maybe it’s some kind of master control switch for anxiety or something? Psychiatrists only know two ways to respond to an exciting new thing: publishing breathless studies claiming that it’s the true mechanism of action for SSRIs, and publishing breathless studies claiming that it’s the true biological basis of depression. This time, they did both: see eg Fluoxetine elevates allopregnanolone levels in female rat brain and The role of allopregnanolone in depressive-like behaviors. The basic theory was that stress / social isolation / etc → decreased allopregnanolone → something something BDNF and synaptogenesis → depression. And SSRIs → increased allopregnanolone → something something BDNF and synpatogenesis → recovery! Change the word “allopregnanolone”, and that’s every theory in psychiatry. But this particular theory had two extra pieces of evidence: premenstrual dysphoric disorder and postpartum depression. Remember, allopregananolone is a natural metabolite of the female hormone progesterone. Progesterone levels go up during pregnancy and the ~18th day of the menstrual cycle, then crash back down after delivery and the ~24th day of the menstrual cycle. Meanwhile, some women get depressed after delivering a baby, or on the ~24th day of their menstrual cycle. Suspicious! Maybe it’s because their progesterone was getting converted into allopregnanolone, an antidepressant hormone that affects mood! (why doesn’t every woman get PPD and PMDD? This study suggests that women with PMDD have altered sensitivity to allopregnanolone; plausibly people with PPD have some other form of altered sensitivity. In case you have the same question I do: the correlation between PMDD and PPD is not 100% but still pretty significant) History of allopregnanolone research (source) The next step was to see if making patients take allopregnanolone can treat these conditions. This is kind of hard, because allopregnanolone is a tough chemical to get into people’s bodies; the traditional method involves sticking an IV into someone and infusing it slowly over several days, and it has to be done in a hospital. Still, Kanes et al tried this in 2017. The study was open-label (ie no placebo) and very small (only four women) but appeared to work extraordinarily well. Four post-partum women who qualified as “severely depressed” when they started the infusion progressed to “completely recovered” within twelve hours. Nothing else except maybe ketamine had produced results like this before. 3: What studies were done on Zulresso? This followup study by Kanes was the first real RCT, although it only had 21 patients. In accordance with the venerable First Study Ever tradition, it found really large positive effects on post-partum depression. That encouraged Sage Therapeutics to fund a bigger Phase 3 trial, Meltzer-Brody (2018). In accordance with venerable Bigger Phase 3 Trial tradition, its results weren’t quite as good as the First Study Ever. But they were still pretty good: Notice that lower doses worked better than higher doses. This is sometimes a red flag on a study. But this time it seems legit; see “Biphasic Actions At The GABA-A Receptor” here for an explanation. Both studies also evaluated side effects. These were generally mild, but two people (about 2% of the study population) lost consciousness. Nothing seemed wrong with them, and researchers mostly attributed this to allopregnanolone being a sedating drug. If you sedate people too hard, they pass out. Faced with these results, the FDA approved allopregnanolone for post-partum depression, but subjected it to a REMS (Risk Evaluation And Mitigation Strategy) - basically, doctors who want to prescribe it will need to take special courses and do extra paperwork. This kind of surprised me - there are plenty of sedating drugs that make you pass out in overdose. Also, since patients will be getting it IV, there will probably be a nurse around to check if they passed out and take appropriate actions if so. But the FDA really likes putting restrictions on things, and I guess this was a free chance for them to do that. 4: Is Zulresso freely available at a doctor’s office near me? It’s possible to get Zulresso, but really hard. Because Zulresso is an IV infusion lasting four days, you need to spend four days somewhere that people can put an IV into you and monitor it. Realistically that means a hospital or some other big medical institution. So this is only available for inpatients. Because of the REMS (extra certification and paperwork), most hospitals aren’t interested. You can find a list of ones that are here - it looks like there are about 89 locations in the US with the right certification. Last but not least, a four-day course of Zulresso costs $35,000 for the medication itself, plus much more for the four-day hospitalization it takes to receive it. As usual, insurances will cover it iff you can document you’ve tried lots of other stuff first. 5: Hold on, does it really cost $35,000? Oho, I see you’ve played the “pharma price analysis” game before. But this time I think the price might actually be defensible. Chemical supply companies (1, 2, 3) generally sell allopregnanolone for $10,000 to $20,000 a gram. (I found one company with a much lower price, but I’m suspicious and am going to dismiss them as an outlier). The usual dose of allopregnanolone is 60 ug/kg/hour x 60 hours, which for a 60 kg person comes out to a total of 0.25g total. Getting that amount from the chemistry supply store would cost about $2,500 - 5,000. I assume pharma-grade allopregnanolone is more expensive than chemistry-store-grade, so it wouldn’t surprise me if a price in the low five-figures was justified by manufacturing alone. Isn’t it still a pretty good deal to find an endogenous neurosteroid, do one or two studies confirming it’s great, produce it for the low five figures, then sell it for the mid five figures? I think maybe not. This drug has a terrible value proposition. Post-partum depression is one of the rarer psych conditions. Most people with PPD won’t check into a hospital and pay $35,000 for a drug infusion. And the people who do will get the drug infusion, feel better, and never need it again (at least until they have another kid) - unlike SSRIs where you can keep charging for monthly prescriptions forever. Sage Therapeutics, the pharma company that owns the patent on Zulresso (and nothing else - this is their only drug!) has done terribly. Their stock is in the doldrums, they almost went bankrupt, and they survived only with the help of a cash infusion by a bigger pharma company. I think this confirms a general trend where at least some expensive medications are pricey because of fundamentals (including regulatory fundamentals) and not just pharma companies making obscene profits. 6: Hold on, how is allopregnanolone different from benzodiazepines? Remember, allopregnanolone is a positive allosteric modulator of GABA, much like benzodiazepines such as Xanax. But Xanax is cheap ($10 for 30 pills). And you can get it at any local pharmacy (plus sometimes on street corners). What’s so special about allopregnanolone that you should pay $35,000 and go into the hospital to get it? The official answer is “allopregnanolone modulates GABA differently from benzodiazepines”. For example, this paper says that: Allopregnanolone allosteric modulation of the action of GABA at GABA-A receptors is much less selective than that of benzodiazepines, which are relatively inactive at α4- or α6-containing GABA-A receptors. If you really like details about receptor subunits, this paper presents the full case. The skeptic’s answer is “who knows?” Psych drugs often work for reasons totally different than we thought. People thought tianeptine was an SSRE for years, until it turned out to be a mild opioid. People thought ketamine was NMDA-ergic for years, until it turned out to be [fill this part in 10 years from now]. Last year a bunch of very smart people tried to claim that SSRI effects had nothing to do with serotonin (I think they were wrong). Just because some guy found that Zulresso acts as a GABA-PAM in some test tube doesn’t mean that’s what’s having any of the relevant antidepressant effects. The troll’s answer is “who says it’s different?” Do benzodiazepines treat depression? Depends who you ask. If you ask benzodiazepine users, their answer is “yes, definitely”. If you ask drug warriors, their answer is “Addictive Substances May Make You Temporarily Feel Good, But They Are Not A Responsible Treatment Option”. If you ask the research literature, it gives vague indeterminate answers, as always. But nobody has ever said benzodiazepines instantly and miraculously cure depression, so how come allopregnanolone seems to do that? A true troll would point out that we probably give allopregnanolone at much higher doses - 2% of allopregnanolone patients were sedated so hard they lost consciousness, whereas this is exactly the sort of side effect I try to avoid when calculating benzodiazepine doses. Maybe if you gave postpartum women an infusion of 300 mg Valium, and maximized your placebo effect by calling it the hot new thing, they’d do pretty well too (several days later, after recovering consciousness). I think the troll answer would be hilarious but I don’t really want to defend it as correct; if I had to bet I’d say the official explanation is the right one. 7: Hold on, why can’t we just give people progesterone and let them metabolize it into allopregnanolone? This turned out to be an interesting enough rabbit hole that I’m going to spin it off into another post later this week. 8: Hold on, people have lots of allopregnanolone when they’re pregnant, right? And then post-partum depression happens when they give birth, and their allopregnanolone level drops. So if you give someone an infusion of allopregnanolone, and then take them off it, that’s a hormonal simulation of giving birth, ie the same thing that caused the problem in the first place? How is that good? Oh, you think you’re clever, do you? What you failed to consider is . . . I didn’t end that sentence because I can’t find anything in the literature addressing this question. But the difference might be that the infusion schedule ramps up gradually, peaks, and then ramps down gradually, which is more of a soft taper than the sudden crash of birth. If anyone knows more about this, please let me know. [EDIT: see this comment] 9: Is allopregnanolone addictive? No, because good luck getting addicted to a $35,000-per-dose chemical. We should probably expect allopregnanolone to be addictive, by analogy to other GABA-PAMs like benzodiazepines and alcohol. But nobody has ever received more than a single dose. You don’t get addicted to benzos after a single pill, or alcohol after a single beer, so in practice AFAIK nobody has ever gotten addicted to this. Or who knows, maybe it’s not addictive. Remember, allopregnanolone is naturally elevated during pregnancy; pregnancy isn’t addictive. And some scientists claim the brain endogenously uses allopregnanolone as a master regulator of depression and anxiety. In theory, if you could give yourself the same amount a non-anxious person’s brain gives them all the time, shouldn’t you be no worse off than that non-anxious person? I don’t know, and remember that your brain also has a lot of endogenous opioids; doesn’t make the exogenous kind any safer. The Drug Enforcement Administration has made Zulresso a Schedule IV controlled substance, which means they’re putting a few very weak restrictions on it but not worrying too much. 10: Does allopregnanolone work for depression that isn’t post-partum? If all psychiatric disorders are secretly allopregnanolone imbalances, then you might expect it to work on all depressions, not just post-partum. I’m sure pharmaceutical executives with dollar signs instead of pupils in their eyes have had this same thought, but I can’t find studies about it. Some of the same people behind the postpartum studies did a very small, very weak study on ganaloxone (a close allopregnanolone relative) for persistent depression; it seemed to work, but also caused a lot of sedation (more than in the postpartum trials? Hard to tell). Nobody’s looked into this further since then, maybe because that was around when the pharma companies realized that the 4-day hospital stay and $35,000 price tag made allopregnanolone a financial loser. The evidence from zuranolone (see below) suggests that allopregnanolone might not work very well against regular depression. 11: What is zuranolone? Wikipedia describes zuranolone as “a swirling, black vortex revered by the Mutsune Native Americans as a dire death god . . . also worshiped by mysterious servitors known as the Hidden Ones.” No! Sorry again! That’s Zushakon, another Great Old One. Zuranolone is Sage Therapeutics’ attempt to turn allopregnanolone into an accessible medication that might actually make them real money. Zuranolone is mostly just allopregnanolone with some extra stuff attached that changes the absorption. Zuranolone can be taken orally, so you don’t have to go to a hospital for four days to receive it IV. It’s potentially less likely to cause loss of consciousness and other undesirable side effects. And it’s under investigation as a potential treatment for postpartum depression, bipolar depression, regular depression, insomnia, and various movement disorders. (that might seem excessive, but benzodiazepines treat a lot of stuff, and if these neurosteroids are kind of like super-benzodiazepines, then this level of optimism might be warranted.) 12: Does zuranolone work? Sage Therapeutics answered this question the same way pharma companies answer every question: with a bunch of studies whose names form overly-cute acronyms. We’ll talk here about ROBIN, WATERFALL, MOUNTAIN, and CORAL - though I assure you there are others. ROBIN tested efficacy in postpartum depression. Results were positive and relatively impressive, about the same as the weaker allopregnanolone studies. WATERFALL, MOUNTAIN, and CORAL tested results in regular depression. WATERFALL was positive but weak. MOUNTAIN was negative. That scared the pharma company and they hacked CORAL to be more likely to give positive results. It did give positive results, but the FDA reads the same biotech magazines I do and knows perfectly well what they did, so I don’t know what Sage expects to gain from this. Overall these trials were disappointing. I think the most likely story is that allopregnanolone = zuranolone, both are moderately effective in postpartum depression, and both have much less efficacy in regular depression, probably not literally zero but also not enough to be worthwhile antidepressants (especially considering cost). Might zuranolone be an excellent anti-anxiety medication? You’d think so - it should be at least as good as benzodiazepines, which are excellent anti-anxiety medications. And researchers seem excited about allopregnanolone as a master regulator of brain anxiety. But the studies aren’t promising. ROBIN and WATERFALL incidentally assessed anxiety; ROBIN found good results in its postpartum population, but WATERFALL found poor-to-mediocre results in its regular population. Studies are hard, and sometimes even really effective drugs can have trouble showing strong results. But these aren’t encouraging. 13: So where do we go from here? Getting FDA approval for zuranolone for postpartum depression seems reasonable; it’ll probably be cheaper and easier than making people go to the hospital to get allopregnanolone. I’m uncertain about the financials of this for Sage, but since they did the study they hopefully think it’s worth it. Otherwise, I’m not sure. It would have been great if zuranolone had shown robust efficacy against regular depression and anxiety, but this is exactly the kind of great thing that never happens in psychopharmacology (motto: “Disappointing Doctors And Patients Since 1982”). It might be worth throwing it against anxiety disorders and PTSD to see if anything sticks, but I wouldn’t bet on it. The research into allopregnanolone as master regulator of brain anxiety states is fascinating, but as far as I know it hasn’t reckoned with the failure of zuranolone to really treat much anxiety. The cynical part of me predicts that once pharma’s done making money off neurosteroids then all of this will die down, and something else that pharma can make more money from will become the master regulator of everything. I expect that the main thing we get out of all this is somewhat better post-partum depression treatment, which might or might not ever become accessible for ordinary people. 14: Predictions In the next five years… Zuranolone gets FDA approval for major depression: 15%
Inline links: source, Fluoxetine elevates allopregnanolone levels in female rat brain, The role of allopregnanolone in depressive-like behaviors, This study, is not 100% but still pretty significant, https://substackcdn.com/image/fetch/$s_!WAyF!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F3c4db9d4-d5f8-45cf-8cde-17e2bbd216b6_904x334.png, source, Kanes et al, This followup study by Kanes, https://substackcdn.com/image/fetch/$s_!3b3x!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F63f81091-7084-4ad3-b0a3-28394059b2c3_369x282.png, Meltzer-Brody (2018), https://substackcdn.com/image/fetch/$s_!l7Uh!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F2b579fea-c6c8-4d46-8de7-c4a3e6852766_797x335.png, here, here, 1, 2, one company, has done terribly, this paper, this paper, tried to claim, their answer is, their answer is, it gives vague indeterminate answers, this comment, a very small, very weak study, describes, https://substackcdn.com/image/fetch/$s_!hqfF!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F5b386f78-93b3-4d16-98c4-6d2eedef5a1f_548x256.png, ROBIN, WATERFALL, MOUNTAIN, CORAL, to be more likely to give positive results
Notice that lower doses worked better than higher doses. This is sometimes a red flag on a study. But this time it seems legit; see “Biphasic Actions At The GABA-A Receptor” here for an explanation. Both studies also evaluated side effects. These were generally mild, but two people (about 2% of the study population) lost consciousness. Nothing seemed wrong with them, and researchers mostly attributed this to allopregnanolone being a sedating drug. If you sedate people too hard, they pass out. Faced with these results, the FDA approved allopregnanolone for post-partum depression, but subjected it to a REMS (Risk Evaluation And Mitigation Strategy) - basically, doctors who want to prescribe it will need to take special courses and do extra paperwork. This kind of surprised me - there are plenty of sedating drugs that make you pass out in overdose. Also, since patients will be getting it IV, there will probably be a nurse around to check if they passed out and take appropriate actions if so. But the FDA really likes putting restrictions on things, and I guess this was a free chance for them to do that. 4: Is Zulresso freely available at a doctor’s office near me? It’s possible to get Zulresso, but really hard. Because Zulresso is an IV infusion lasting four days, you need to spend four days somewhere that people can put an IV into you and monitor it. Realistically that means a hospital or some other big medical institution. So this is only available for inpatients. Because of the REMS (extra certification and paperwork), most hospitals aren’t interested. You can find a list of ones that are here - it looks like there are about 89 locations in the US with the right certification. Last but not least, a four-day course of Zulresso costs $35,000 for the medication itself, plus much more for the four-day hospitalization it takes to receive it. As usual, insurances will cover it iff you can document you’ve tried lots of other stuff first. 5: Hold on, does it really cost $35,000? Oho, I see you’ve played the “pharma price analysis” game before. But this time I think the price might actually be defensible. Chemical supply companies (1, 2, 3) generally sell allopregnanolone for $10,000 to $20,000 a gram. (I found one company with a much lower price, but I’m suspicious and am going to dismiss them as an outlier). The usual dose of allopregnanolone is 60 ug/kg/hour x 60 hours, which for a 60 kg person comes out to a total of 0.25g total. Getting that amount from the chemistry supply store would cost about $2,500 - 5,000. I assume pharma-grade allopregnanolone is more expensive than chemistry-store-grade, so it wouldn’t surprise me if a price in the low five-figures was justified by manufacturing alone. Isn’t it still a pretty good deal to find an endogenous neurosteroid, do one or two studies confirming it’s great, produce it for the low five figures, then sell it for the mid five figures? I think maybe not. This drug has a terrible value proposition. Post-partum depression is one of the rarer psych conditions. Most people with PPD won’t check into a hospital and pay $35,000 for a drug infusion. And the people who do will get the drug infusion, feel better, and never need it again (at least until they have another kid) - unlike SSRIs where you can keep charging for monthly prescriptions forever. Sage Therapeutics, the pharma company that owns the patent on Zulresso (and nothing else - this is their only drug!) has done terribly. Their stock is in the doldrums, they almost went bankrupt, and they survived only with the help of a cash infusion by a bigger pharma company. I think this confirms a general trend where at least some expensive medications are pricey because of fundamentals (including regulatory fundamentals) and not just pharma companies making obscene profits. 6: Hold on, how is allopregnanolone different from benzodiazepines? Remember, allopregnanolone is a positive allosteric modulator of GABA, much like benzodiazepines such as Xanax. But Xanax is cheap ($10 for 30 pills). And you can get it at any local pharmacy (plus sometimes on street corners). What’s so special about allopregnanolone that you should pay $35,000 and go into the hospital to get it? The official answer is “allopregnanolone modulates GABA differently from benzodiazepines”. For example, this paper says that: Allopregnanolone allosteric modulation of the action of GABA at GABA-A receptors is much less selective than that of benzodiazepines, which are relatively inactive at α4- or α6-containing GABA-A receptors. If you really like details about receptor subunits, this paper presents the full case. The skeptic’s answer is “who knows?” Psych drugs often work for reasons totally different than we thought. People thought tianeptine was an SSRE for years, until it turned out to be a mild opioid. People thought ketamine was NMDA-ergic for years, until it turned out to be [fill this part in 10 years from now]. Last year a bunch of very smart people tried to claim that SSRI effects had nothing to do with serotonin (I think they were wrong). Just because some guy found that Zulresso acts as a GABA-PAM in some test tube doesn’t mean that’s what’s having any of the relevant antidepressant effects. The troll’s answer is “who says it’s different?” Do benzodiazepines treat depression? Depends who you ask. If you ask benzodiazepine users, their answer is “yes, definitely”. If you ask drug warriors, their answer is “Addictive Substances May Make You Temporarily Feel Good, But They Are Not A Responsible Treatment Option”. If you ask the research literature, it gives vague indeterminate answers, as always. But nobody has ever said benzodiazepines instantly and miraculously cure depression, so how come allopregnanolone seems to do that? A true troll would point out that we probably give allopregnanolone at much higher doses - 2% of allopregnanolone patients were sedated so hard they lost consciousness, whereas this is exactly the sort of side effect I try to avoid when calculating benzodiazepine doses. Maybe if you gave postpartum women an infusion of 300 mg Valium, and maximized your placebo effect by calling it the hot new thing, they’d do pretty well too (several days later, after recovering consciousness). I think the troll answer would be hilarious but I don’t really want to defend it as correct; if I had to bet I’d say the official explanation is the right one. 7: Hold on, why can’t we just give people progesterone and let them metabolize it into allopregnanolone? This turned out to be an interesting enough rabbit hole that I’m going to spin it off into another post later this week. 8: Hold on, people have lots of allopregnanolone when they’re pregnant, right? And then post-partum depression happens when they give birth, and their allopregnanolone level drops. So if you give someone an infusion of allopregnanolone, and then take them off it, that’s a hormonal simulation of giving birth, ie the same thing that caused the problem in the first place? How is that good? Oh, you think you’re clever, do you? What you failed to consider is . . . I didn’t end that sentence because I can’t find anything in the literature addressing this question. But the difference might be that the infusion schedule ramps up gradually, peaks, and then ramps down gradually, which is more of a soft taper than the sudden crash of birth. If anyone knows more about this, please let me know. [EDIT: see this comment] 9: Is allopregnanolone addictive? No, because good luck getting addicted to a $35,000-per-dose chemical. We should probably expect allopregnanolone to be addictive, by analogy to other GABA-PAMs like benzodiazepines and alcohol. But nobody has ever received more than a single dose. You don’t get addicted to benzos after a single pill, or alcohol after a single beer, so in practice AFAIK nobody has ever gotten addicted to this. Or who knows, maybe it’s not addictive. Remember, allopregnanolone is naturally elevated during pregnancy; pregnancy isn’t addictive. And some scientists claim the brain endogenously uses allopregnanolone as a master regulator of depression and anxiety. In theory, if you could give yourself the same amount a non-anxious person’s brain gives them all the time, shouldn’t you be no worse off than that non-anxious person? I don’t know, and remember that your brain also has a lot of endogenous opioids; doesn’t make the exogenous kind any safer. The Drug Enforcement Administration has made Zulresso a Schedule IV controlled substance, which means they’re putting a few very weak restrictions on it but not worrying too much. 10: Does allopregnanolone work for depression that isn’t post-partum? If all psychiatric disorders are secretly allopregnanolone imbalances, then you might expect it to work on all depressions, not just post-partum. I’m sure pharmaceutical executives with dollar signs instead of pupils in their eyes have had this same thought, but I can’t find studies about it. Some of the same people behind the postpartum studies did a very small, very weak study on ganaloxone (a close allopregnanolone relative) for persistent depression; it seemed to work, but also caused a lot of sedation (more than in the postpartum trials? Hard to tell). Nobody’s looked into this further since then, maybe because that was around when the pharma companies realized that the 4-day hospital stay and $35,000 price tag made allopregnanolone a financial loser. The evidence from zuranolone (see below) suggests that allopregnanolone might not work very well against regular depression. 11: What is zuranolone? Wikipedia describes zuranolone as “a swirling, black vortex revered by the Mutsune Native Americans as a dire death god . . . also worshiped by mysterious servitors known as the Hidden Ones.” No! Sorry again! That’s Zushakon, another Great Old One. Zuranolone is Sage Therapeutics’ attempt to turn allopregnanolone into an accessible medication that might actually make them real money. Zuranolone is mostly just allopregnanolone with some extra stuff attached that changes the absorption. Zuranolone can be taken orally, so you don’t have to go to a hospital for four days to receive it IV. It’s potentially less likely to cause loss of consciousness and other undesirable side effects. And it’s under investigation as a potential treatment for postpartum depression, bipolar depression, regular depression, insomnia, and various movement disorders. (that might seem excessive, but benzodiazepines treat a lot of stuff, and if these neurosteroids are kind of like super-benzodiazepines, then this level of optimism might be warranted.) 12: Does zuranolone work? Sage Therapeutics answered this question the same way pharma companies answer every question: with a bunch of studies whose names form overly-cute acronyms. We’ll talk here about ROBIN, WATERFALL, MOUNTAIN, and CORAL - though I assure you there are others. ROBIN tested efficacy in postpartum depression. Results were positive and relatively impressive, about the same as the weaker allopregnanolone studies. WATERFALL, MOUNTAIN, and CORAL tested results in regular depression. WATERFALL was positive but weak. MOUNTAIN was negative. That scared the pharma company and they hacked CORAL to be more likely to give positive results. It did give positive results, but the FDA reads the same biotech magazines I do and knows perfectly well what they did, so I don’t know what Sage expects to gain from this. Overall these trials were disappointing. I think the most likely story is that allopregnanolone = zuranolone, both are moderately effective in postpartum depression, and both have much less efficacy in regular depression, probably not literally zero but also not enough to be worthwhile antidepressants (especially considering cost). Might zuranolone be an excellent anti-anxiety medication? You’d think so - it should be at least as good as benzodiazepines, which are excellent anti-anxiety medications. And researchers seem excited about allopregnanolone as a master regulator of brain anxiety. But the studies aren’t promising. ROBIN and WATERFALL incidentally assessed anxiety; ROBIN found good results in its postpartum population, but WATERFALL found poor-to-mediocre results in its regular population. Studies are hard, and sometimes even really effective drugs can have trouble showing strong results. But these aren’t encouraging. 13: So where do we go from here? Getting FDA approval for zuranolone for postpartum depression seems reasonable; it’ll probably be cheaper and easier than making people go to the hospital to get allopregnanolone. I’m uncertain about the financials of this for Sage, but since they did the study they hopefully think it’s worth it. Otherwise, I’m not sure. It would have been great if zuranolone had shown robust efficacy against regular depression and anxiety, but this is exactly the kind of great thing that never happens in psychopharmacology (motto: “Disappointing Doctors And Patients Since 1982”). It might be worth throwing it against anxiety disorders and PTSD to see if anything sticks, but I wouldn’t bet on it. The research into allopregnanolone as master regulator of brain anxiety states is fascinating, but as far as I know it hasn’t reckoned with the failure of zuranolone to really treat much anxiety. The cynical part of me predicts that once pharma’s done making money off neurosteroids then all of this will die down, and something else that pharma can make more money from will become the master regulator of everything. I expect that the main thing we get out of all this is somewhat better post-partum depression treatment, which might or might not ever become accessible for ordinary people. 14: Predictions In the next five years… Zuranolone gets FDA approval for major depression: 15%
Inline links: here, here, 1, 2, one company, has done terribly, this paper, this paper, tried to claim, their answer is, their answer is, it gives vague indeterminate answers, this comment, a very small, very weak study, describes, https://substackcdn.com/image/fetch/$s_!hqfF!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F5b386f78-93b3-4d16-98c4-6d2eedef5a1f_548x256.png, ROBIN, WATERFALL, MOUNTAIN, CORAL, to be more likely to give positive results
Zuranolone is mostly just allopregnanolone with some extra stuff attached that changes the absorption. Zuranolone can be taken orally, so you don’t have to go to a hospital for four days to receive it IV. It’s potentially less likely to cause loss of consciousness and other undesirable side effects. And it’s under investigation as a potential treatment for postpartum depression, bipolar depression, regular depression, insomnia, and various movement disorders. (that might seem excessive, but benzodiazepines treat a lot of stuff, and if these neurosteroids are kind of like super-benzodiazepines, then this level of optimism might be warranted.) 12: Does zuranolone work? Sage Therapeutics answered this question the same way pharma companies answer every question: with a bunch of studies whose names form overly-cute acronyms. We’ll talk here about ROBIN, WATERFALL, MOUNTAIN, and CORAL - though I assure you there are others. ROBIN tested efficacy in postpartum depression. Results were positive and relatively impressive, about the same as the weaker allopregnanolone studies. WATERFALL, MOUNTAIN, and CORAL tested results in regular depression. WATERFALL was positive but weak. MOUNTAIN was negative. That scared the pharma company and they hacked CORAL to be more likely to give positive results. It did give positive results, but the FDA reads the same biotech magazines I do and knows perfectly well what they did, so I don’t know what Sage expects to gain from this. Overall these trials were disappointing. I think the most likely story is that allopregnanolone = zuranolone, both are moderately effective in postpartum depression, and both have much less efficacy in regular depression, probably not literally zero but also not enough to be worthwhile antidepressants (especially considering cost). Might zuranolone be an excellent anti-anxiety medication? You’d think so - it should be at least as good as benzodiazepines, which are excellent anti-anxiety medications. And researchers seem excited about allopregnanolone as a master regulator of brain anxiety. But the studies aren’t promising. ROBIN and WATERFALL incidentally assessed anxiety; ROBIN found good results in its postpartum population, but WATERFALL found poor-to-mediocre results in its regular population. Studies are hard, and sometimes even really effective drugs can have trouble showing strong results. But these aren’t encouraging. 13: So where do we go from here? Getting FDA approval for zuranolone for postpartum depression seems reasonable; it’ll probably be cheaper and easier than making people go to the hospital to get allopregnanolone. I’m uncertain about the financials of this for Sage, but since they did the study they hopefully think it’s worth it. Otherwise, I’m not sure. It would have been great if zuranolone had shown robust efficacy against regular depression and anxiety, but this is exactly the kind of great thing that never happens in psychopharmacology (motto: “Disappointing Doctors And Patients Since 1982”). It might be worth throwing it against anxiety disorders and PTSD to see if anything sticks, but I wouldn’t bet on it. The research into allopregnanolone as master regulator of brain anxiety states is fascinating, but as far as I know it hasn’t reckoned with the failure of zuranolone to really treat much anxiety. The cynical part of me predicts that once pharma’s done making money off neurosteroids then all of this will die down, and something else that pharma can make more money from will become the master regulator of everything. I expect that the main thing we get out of all this is somewhat better post-partum depression treatment, which might or might not ever become accessible for ordinary people. 14: Predictions In the next five years… Zuranolone gets FDA approval for major depression: 15%
Inline links: ROBIN, WATERFALL, MOUNTAIN, CORAL, to be more likely to give positive results
postrationalism1 mentions across 1 issues

postrationalism is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between August 19, 2022 and August 19, 2022. The archive places it in contexts such as "The only movement I see that’s still clearly high on “we are so great and such good friends with each other” is postrationalism". It most often appears alongside 00s, 70s, 80s.

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postrationalism
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1
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August 19, 2022
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August 19, 2022
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Highlights From The Comments On Subcultures
August 19, 2022 · Original source
Postcycle: Since 2020 Now things are pretty stable, partly because we put enough distance between ourselves and our growth phase that we can start to get a little hipster cool again, and partly because effective altruism is the Hot New Thing that everyone is supposed to have an opinion on. This is the usual pattern of exciting talked-about movements spawning successor movements that then get to be exciting and talked-about in turn, while the original movement gets to go back to being normal people with a common interest again. By the way, in the past week, effective altruism has gotten long, glowing profiles in the New Yorker, the New York Times, Vox, the cover of TIME Magazine, shoutouts from Elon Musk and Andrew Yang, podcast interviews with Tyler Cowen and Tim Ferriss, and criticism from Freddie deBoer. Enjoy it while it lasts! ___________________ 7: MT writes: A lot of this sounds like truism, or selection bias. Thing isn't popular or exciting to most, then it catches on and grows, then it stops growing, fragments into new directions and isn't novel but becomes part of the mainstream. This HAS TO describe literally anything in the past that was ever popular/exciting, because it wasn't always that way (started small) and can't grow indefinitely without becoming either an institution (stable leadership/direction), fragmented (new leadership/direction), or just falling apart. The germ of this idea was my feeling that I’ve been in movements where it starts out feeling like everyone can’t stop gushing about how great we are, and then later there’s another phase where criticism reigns and everyone feels slightly embarrassed to be involved. This doesn’t feel tautological to me, although it might become trivial if you allow enough selection bias (some movement where this hasn’t happened “isn’t the kind of movement this happens to”). I could prove this by making nontrivial predictions about which movements are going to get less camaraderie and more internecine struggle in the future. Four years ago I would have said “new left socialism”, and I think I did endorse Robby Soave’s article to that effect at the time, but I think new left socialism is well into involution or even postcycle now. Last year I would have said YIMBYism, but I’m not up-to-date on it and maybe it’s already transitioned too. The only movement I see that’s still clearly high on “we are so great and such good friends with each other” is postrationalism/ingroup/TPOT, so sure, I expect things to get worse for them (sorry for this potentially self-fulfilling prophecy). (I’m nervous about saying EA because they still have more money than they can spend in a reasonable amount of time; as long as that situation continues they won’t be exactly resource-scarce, and the people with the purse-strings will have a natural advantage as “elites”.) I’m actually surprised how few uncomplicated happy growth spurt movements I can think of now, compared to how many I can think of that seem to have passed through that stage. I think this is a combination of: This is a pretty pessimistic social moment (eg the thing where dystopian SF has become more popular than the utopian SF of the late 20th century).
Inline links: the New Yorker, New York Times, Vox, cover of TIME Magazine, Elon Musk, Andrew Yang, Tyler Cowen, Tim Ferriss, Freddie deBoer, MT, Robby Soave’s article to that effect, postrationalism/ingroup/TPOT
postviral fatigue1 mentions across 1 issues

postviral fatigue is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between September 02, 2021 and September 02, 2021. The archive places it in contexts such as "official diagnosis of “CFS/ME” ...is much worse than “postviral fatigue”". It most often appears alongside 1DaySooner, AC&E, AcesoUnderGlass.

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postviral fatigue
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1
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September 02, 2021
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Long COVID: Much More Than You Wanted To Know
September 02, 2021 · Original source
This is terrible. Recovery rates in the single digit percentages over the space of years. You would think at least some patients would get placebo recoveries, or forget how it felt to be well, or otherwise Lizardman themselves into fake complacency, but no. This is f@#$ing awful. Maybe COVID won’t be this bad? One ray of hope comes from this Australian study, where doctors record the rates of recovery from postviral fatigue after various rare diseases they encounter (Epstein-Barr, Q fever, Ross River virus). They find that 35% of these patients have postviral fatigue after six weeks, but only 12% after six months, and 9% after twelve months. This sounds a lot better than chronic fatigue. In fact, these people do the kind of weird task of figuring out how bad different diagnostic labels for fatigue are, even though some might argue that all the labels refer to the same underlying reality. They find an official diagnosis of “CFS/ME” (chronic fatigue / myalgic encephalitis) is much worse than “postviral fatigue”. Using the weird measure of “days per year of followup with diagnosis” (I’m not sure I fully understand their reasoning for why this is good), they find a median length of 80 for CFS/ME vs. 0 for PVF (…huh?). Using the more comprehensible measure of percent who still complain of fatigue after 7-12 months, they find it’s 24% vs. 10% (which super contradicts the above study saying that basically nobody with a CFS/ME diagnosis ever recovers). My guess is that this study had much lower criteria for a CFS/ME diagnosis (some doctor diagnosed it and put it on the insurance records) compared to the ones above (some specialist confirmed it by official criteria). The conclusion I draw is that, while official CFS/ME is horrible and hopeless, there are a lot of things that unofficially look kind of chronic-fatigue-ish which have pretty good prognoses. Since there’s no good reason to think post-COVID fatigue is official CFS/ME as opposed to just some chronic-ish fatigue-ish thing, probably it will have a better prognosis, more like weird Australian viruses. …which we still don’t know, because AFAICT nobody has done any good studies on postviral fatigue lasting more than a year. 5. Psychosomatic symptoms probably aren’t the majority of long COVID. I mean, I’m not seeing too many people claiming that they are. There are a lot more people worried that someone else might be claiming that, than people actually making the claim. Still, the Wall Street Journal opinion section is always up for slathering itself in glue and rolling around in a haystack until it becomes the straw man everyone else warned you about, and they do have an article on The Dubious Origins Of Long COVID. They point out that long COVID was first thrust into the public consciousness in surveys run by Body Politic, who self-describe as “a queer feminist wellness collective merging the personal and the political”. I agree this is a weird source for something to come from, but Hans Asperger was a Nazi and I still use his diagnosis, so I probably have to accept these people’s as well. More relevantly, WSJ points out that many of the people complaining of Long COVID symptoms test negative for COVID, or at least never tested positive. This complaint conflates the fact that not everyone was able to get a COVID test at all, with the fact that sometimes you get the acute COVID test after you’ve recovered from acute COVID and it’s negative, with the fact that COVID tests don’t have a 100% success rate, with the fact that yeah, okay, some people who didn’t have COVID are probably imagining Long COVID symptoms. I feel like some of the case-control studies above, which clearly show that seropositive people have higher rates of Long COVID than seronegative people, are pretty convincing here. But also - the people with lung scarring clearly have lung scarring, and most of them have weird x-rays consistent with lung scarring. If you have lung scarring, then you have trouble breathing, you’re fatigued, and you probably have lots of other stuff downstream of that. The people with smell/taste disturbances clearly have smell/taste disturbances, testable with the stupidly named but scientifically venerable Sniffin Sticks test - and also, who even cares enough to make up olfactory problems? Fatigue and brain fog are the only symptoms here that can’t be easily objectively confirmed, and, well, do you think those Australians who got infected with Q fever and had twelve months of postviral fatigue are faking? What about all those post-Epstein Barr fatigue people? Lots of viruses cause postviral fatigue, it’s not really surprising that COVID should also. (WSJ also spends a while arguing that CFS/ME is just a psychiatric disorder, which I think is not really in keeping with the best recent evidence. Also, as a psychiatrist, I’m very against this conclusion, mostly because if it were true, then people would expect me to cure CFS/ME patients.) One point WSJ didn’t bring up but could have was that most Long COVID patients are women. Probably this is somewhere between 60 and 80% - I suspect on the lower end of this, because I think women are more likely to talk about these kinds of things than men, and much more likely to eg join Facebook groups. This is noteworthy, because women are traditionally more prone to psychosomatic illnesses - so much that the ancients attributed these to the uterus and called them hysteria (note shared root with eg “hysterectomy”). Women are about 2x as likely to get diagnosed with panic disorder, anxiety disorders, phobias, etc, about 2.5x as likely to get chronic Lyme disease, widely regarded as an entirely psychosomatic condition, and 3-5x more likely to be diagnosed with fibromyalgia. So the female preponderance is suspicious. But women are also somewhere between 2x and 4x more likely to get autoimmune disorders than men (it varies by disorder - the ratio for Sjogren’s is as high as 16x). There are some pretty crazy hypotheses for why this is - for example, maybe women’s immune systems are permanently upregulated to be prepared for attempts by the placenta to secrete immune-downregulating chemicals during pregnancy, as part of the creepy shadow war between mother and fetus to regulate the maternal environment. I don’t know, do you have a better idea? Anyway, women have more autoimmune issues and more upregulated immune systems, so if there was any good way to assess gender ratio in true postviral fatigue excluding all psychosomatic cases, that would probably be female-biased too. Probably some Long COVID cases are psychosomatic just like some cases of anything are psychosomatic, but I don’t see too many signs that this is too important in explaining the phenomenon. …and please allow me a moment of preachiness here. Chronic fatigue sounds really fake to anyone who doesn’t have it. I think this is because it’s related to willpower. Willpower itself would sound fake to anyone who didn’t have to worry about it. “Oh, so you can go partying with your friends whenever you want, but as soon as it comes time to write a ten page report, your ‘lack of willpower’ prevents you from doing it? A likely story!” Still, all of us (except Bryan Caplan) recognize how real and important willpower is - how having more of it is better than having less of it, and how some condition that caused you to have pathologically little of it would be a huge disaster. In the comments section to the rough draft of this post, CJ wrote: I will say - I was one of those types of men to scoff with skepticism at people claiming to have chronic fatigue and the like. I would have called those people lazy and would have been adamant they were faking it or feeling like crap because of unhealthy lifestyle choices. Unfortunately I have learned the hard way the severity of neurological conditions, what it feels like to have brain fog, what chronic fatigue feels like, and how difficult it can be to communicate neurological symptoms to others. I now start from a position of listening to people who are willing to open up about their symptoms and trust that they are being honest. There are millions of people suffering in silence with untreated and undiagnosed disorders - those people are not all faking it or just dealing with psychosomatic conditions. I would recommend Jennifer Brea's documentary, Unrest. Thank you for shedding some light on the subject. Heron added: I second the suggestion to watch 'Unrest,' and to consider the many unseen ill whose symptoms are deemed to be imagined. Until this last year, I had little patience with, and doubted, people who I saw as hypochondriacs. Then I became the thing I hated. Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Long COVID do have similarities from what I've read, since becoming ill in August 2020. At that time, here in Northern Ireland, there was scant availability of COVID tests; after spending three days trying to get hold of one, (by which time I'd stopped teaching my post-grad online classes & I haven't worked since) I became too ill to do anything. I figured if this was COVID I'd gotten off lightly, mostly constant severe headache, inability to think, a new experience of fatigue, high temperature, insomnia, hypersomnia, paresthesia, no smell or taste etc Debilitated but not dead. Except for the fact that I still have the aforementioned symptoms a year on and whilst they fluctuate in type and severity, the fatigue, headaches and cognitive difficulties are real. A brain scan, an appointment for brain and spinal MRIs (waiting lists, even when going private [as NHS has 3-8 yr waiting lists here in NI] are lengthy), rare virtual doctors and neurologists suggest my ailments constitute a post-viral thing, maybe Long C, they can offer nothing but pills for pain. There is no test for ME/CFS yet, nor a Long C test, symptoms and presentation are so varied. Given a widespread lack of knowledge and resources regarding these ailments, you're on your own. Maybe I've developed ME, I certainly have post-exertional malaise which my very prominent neurologist hadn't heard of. Looking at the history of ME/CFS* and a dearth of research surrounding it, I hope that rather than dismiss the lives of sufferers of this or the long-lasting aftermath of COVID, that those experiencing such difficulties will be heard and learnt from. I only understood when I had no alternative. I don’t think I ever actively pooh-poohed CFS, but like everyone else who encountered it, I underestimated just how bad it was until I met some patients with the condition. It is real and really bad. For whatever reason it is hard to think about and take seriously, but it really is as bad as people say. </preachiness> 6. Long COVID is probably rare in children This matters a lot, because children are (currently) ineligible for the vaccine, and also likely to encounter the virus at school. But children usually have mild cases of COVID and don’t die from it, so it’s tempting to just not worry about them. But if they could get Long COVID, that would make it much less tempting. Preliminary Evidence On Long COVID In Children sounds like a good paper to draw conclusions from. It says 42.6% of children with COVID experience long-term follow-up symptoms, which would be higher than the rate for adults. But it has no control group, and most of the symptoms it finds don’t seem very COVID-related (eg rashes, constipation). The most common symptom (20%) is insomnia, which better studies in adults fail to associate with real Long COVID. The rate of known long COVID symptoms (eg taste and smell problems) is only about 3-4%, and no higher or lower than anything else. Probably these kids are just having problems at the usual rate and attributing them to their recent COVID. Blankenburg et al do the correct thing and ask a thousand children about potential symptoms, then compare the number who say yes vs. no among COVID-seropositive and seronegative subjects. They find no difference between the two groups. Both are reporting a lot of insomnia, etc. They reasonably attribute this to pandemics being a stressful event that it’s natural to lose sleep over. This is really reassuring, but it can’t rule out a somewhat rarer syndrome. The authors say that they might miss symptoms with a prevalence of less than 10%, and one of them gives his own personal guess that it’s 1%. An English team says there’s a Long COVID rate of 4.6% in kids. But there was a 1.7% rate of similar symptoms in the control group of kids who didn’t have COVID, so I think it would be fair to subtract that and end up with 2.9%. And even though the study started with 5000 children, so few of them got COVID, and so few of those got long COVID, that the 2.9% turns out to be about five kids. I don’t really want to update too much based on five kids, especially given the risk of recall bias (ie you might notice / care about your symptoms more if you know you had COVID before getting them). My overall conclusion here is that long COVID is rarer in children than adults, and may not exist at all. The studies tell us it’s probably somewhere less than 5% of kids, but so far we can’t conclude anything stronger than that. 7. Vaccination probably doesn’t change the per-symptomatic-case risk of Long COVID much Here’s a complicated Twitter thread about this. Of vaccinated people who got symptomatic COVID, about a third ended up with Long COVID symptoms, the same rate as in unvaccinated people. Of course, vaccinated people are much less likely to get symptomatic COVID. But even conditional on getting it, they’re still much less likely to go to the hospital, die, etc. It would have been nice if the same was true of getting Long COVID. But it doesn’t look that way. (all this information is from an online poll by a sketchy group of COVID “survivor” activists. But they wrote up their poll in the scientific paper font, as a PDF and everything, so I say we count it anyway) This NEJM study wasn’t exactly designed to look for Long COVID in vaccinated people. But they found it anyway, at a rate of 19% after 6 weeks. This also fits within the (wide) range reported for unvaccinated people. They don’t give a symptom breakdown beyond “prolonged loss of smell, persistent cough, fatigue, weakness, dyspnea, or myalgia”, which sounds like the usual set. These studies are pretty weak, and you could argue that given that vaccines decrease the average severity of COVID infection, and infection severity is linked to Long COVID risk, we should have a strong prior on vaccines decreasing Long COVID risk. And just before publishing this, someone sent me this study, which very preliminarily finds vaccines might decrease Long COVID risk by a factor of 2. I think a factor of 2-3 is believable; one of 10 or 20, less so. Weirdly, there are some claims that vaccines can help relieve symptoms of existing long COVID. Sounds kind of like sympathetic magic to me, but the researcher quoted in the linked article said it might “improve symptoms by eliminating any virus or viral remnants left in the body” or by “rebalancing the immune system”. So yeah, sympathetic magic. 8. Your risk of a terrible long COVID outcome conditional on COVID is probably between a few tenths of a percent and a few percent. My original calculation went like this: About 25% of people who get COVID report long COVID symptoms. About half of those go away after a few months, so 12.5% get persistent symptoms. Suppose that half of those cases (totally made-up number) are very mild and not worth worrying about. Then 6.25% of people who get COVID would have serious long-lasting Long COVID symptoms. After doing that calculation, I read this essay by Matt Bell, who tries to figure out the same thing. He is much more optimistic. He agrees that about half of long COVID cases go away after a few months, but adds another 50% decrease from “few months” to “lifelong”, kind of on priors, admitting there’s not too much positive evidence for this. Then he adds another factor-of-two decrease from vaccination, based on very preliminary studies from the UK. He estimates that someone with my demographics (vaccinated man in his 30s) has a 2% risk of Long COVID conditional on getting COVID at all. Then he divides by five for the true worst case scenario, based on studies showing that a fifth of people with Long COVID report that it affects their daily activities “a lot”. So by his final number, I have an 0.4% chance of getting really terrible long COVID, conditional on getting COVID at all. My friend AcesoUnderGlass also did a writeup of this, published after I did my first-draft calculation, which seems to be thinking of this very differently, based entirely on hospitalization rates (which of course are very low in vaccinated people our age). She accordingly concludes that risk is very low. I don’t really understand her reasoning here, but I trust her a lot and am working on trying to converge with her on this. What’s my yearly risk of getting COVID if I try to live a normal life? This site says only 0.1% of vaccinated Californians have gotten COVID after their vaccination. But vaccination was pretty new when that survey was done, so we might want to take this as a per one-to-two-months estimate. That would mean a risk of 0.5 - 1 percent per year. But not all these people are living normal lives, so my risk might be higher. MicroCOVID gives me a good sense of how careful I’d have to be to stay within a risk budget of 1% COVID risk per year. When I play around with it, I think I am about 5x - 10x less careful than that, which would mean a risk of about 5%/year. This tracker suggests my area has recently had about 1 new case per thousand people per week, which would imply 5% per year. But most of those people are probably unvaccinated, so my risk would be significantly lower than that. I’m going to round all of this off to about 1% - 10% per year of getting a breakthrough COVID case (though obviously this could change if the national picture got better or worse). Combined with the 0.4% to 6.25% risk of getting terrible long COVID conditional on getting COVID, that’s between a 1/150 - 1/25,000 chance of terrible long COVID per year. How does this compare to other risks? My ordinary risk of death per year, just from being a man in his 30s, is about 1/700 (though this includes drug abusers and stunt pilots, so my real risk might be lower, let’s say 1/1000). Here are some other risks, courtesy of the BMJ: In this context, I find the 1/150 risk pretty scary and the 1/25,000 risk not scary at all, so, darn, I guess there’s not yet enough data to have a strong sense of how concerned I should be. 9. This is hard to compare to other postviral syndromes Going into this, I wondered if we might be able to ignore Long COVID. The argument would go like this: all viral diseases have a risk of postviral syndromes. Colds, flus, mono, lots of stuff that’s going around all the time. Lots of people get those postviral syndromes, and either recover or don’t, but either way we don’t make a big deal out of it. Since COVID’s considered “newsworthy” in a way flu isn’t, we obsess over its postviral syndrome even though it’s no worse than anything else’s. This wouldn’t make Long COVID any less bad, and maybe we would be wrong to not panic more about colds and the flu, but it would at least give us some context and make things feel less scary. Unfortunately, I can’t find anything supporting or opposing this picture. The only relevant study is a meta-analysis by Poole-Wright et al, who (contra nominative determinism) don’t pool the studies by condition, which makes it hard to draw conclusions. I think all of their examples of postviral syndrome after flu are from severe hospitalized cases, so any comparison with COVID would be unfair. Although there do seem to be scattered reports of post-flu problems, they’ve never been formally studied or quantified. Mononucleosis is an infectious disease caused by the Epstein-Barr virus, affecting about 1/2000 people per year in developed countries. It has a famously nasty postviral syndrome, which this paper describes as “almost one-half of the group had substantial ongoing symptoms 2 months after onset and… ∼10% had disabling symptoms marked by fatigue lasting ≥ 6 months”. Flu is as common as COVID, but nobody really talks about it having a significant postviral syndrome so probably it’s not that bad. Mono has a worse postviral syndrome than COVID, but it’s rare enough that it doesn’t cause massive society-wide effects. COVID is right in the middle: more common than mono, and (probably) worse postviral syndrome than flu. I think it’s fair to say that we may not have encountered a condition with this exact combination of risk factors and can’t dismiss it as similar to conditions we currently ignore. One potential analogue might be the Spanish Flu of 1918. It was an equally widespread pandemic, and seemed to have some kind of postviral syndrome. From TIME: In what is now Tanzania, to the north, post-viral syndrome has been blamed for triggering the worst famine in a century—the so-called “famine of corms”—after debilitating lethargy prevented flu survivors from planting when the rains came at the end of 1918. “Agriculture suffered particular disruption because, not only did the epidemic coincide with the planting season in some parts of the country, but in others it came at the time for harvesting and sheep-shearing.” Kathleen Brant, who lived on a farm in Taranaki, New Zealand, told Rice, the historian, about the “legion” problems farmers in her district encountered following the pandemic, even though all patients survived: “The effects of loss of production were felt for a long time.” The 1918 flu seemed to have lots of psychiatric effects: “Norwegian demographer Svenn-Erik Mamelund provided such evidence when he combed the records of psychiatric institutions in his country to show that the average number of admissions showed a seven-fold increase in each of the six years following the pandemic, compared to earlier, non-pandemic years.” Coronavirus doesn’t - the excellent Amin-Chowdhury study above finds nothing. Still, this is the scale of thing I’m worried about. The worst case scenario here is really really bad. If a few percent of COVID patients get long-term unremitting genuine CFS/ME, that has the potential to overwhelm government welfare budgets and long-term depress the economy. I think there’s a 90% chance the real situation isn’t that bad, but it’s scary that we can’t entirely rule it out. Aside from the somewhat different 1918 case, I don’t think we have any historical experience of dealing with postviral syndromes at this scale. The medium case scenario is something more like “a few percent of infected people get moderate fatigue, which doesn’t really prevent them from working, and goes away after a few years”. I don’t know whether the level of media attention paid to this would converge on “boring and nobody notices” or “giant disaster”, and I think it would be compatible with either. 10. Conclusions 1. Long COVID is many different issues without a common mechanism. 2. Some of these are straightforward and not surprising, eg lung scarring and post-ICU syndrome from severe infection, and would happen in any disease of this severity. Others seem to be more like the poorly-understood postviral syndromes associated with several other diseases. While some symptoms may be psychosomatic, most are probably organic. 3 The three major categories of symptoms are straightforward cardiovascular-pulmonary issues, straightforward smell and taste issues, and more mysterious neurological issues. 4 Although these get better with time in some people, in a significant number (maybe ~50% of people who had them at six weeks) they persist for as long as anyone has been able to measure them (a few months in the case of COVID, a year or two in the case of comparable syndromes). 5. Post-COVID fatigue is particularly concerning. This would be very bad if we analogized it to CFS/ME, and still pretty bad if we analogized it to other known postviral syndromes. There is no proof that this always gets better over the long term, although no study has looked at them for more than a few years. Facing postviral fatigue on this scale is a new problem. 6 . Children probably get Long COVID less than adults, probably at a rate of less than 5% of symptomatic cases. But we don’t know how much less, and we can’t rule out that some children get pretty severe symptoms. 7. Although vaccination decreases the risk of symptomatic COVID, it probably doesn’t decrease the risk of Long COVID per symptomatic COVID case by very much, though it might decrease it by a factor of 2-3. 8. Your chance of really bad debilitating lifelong Long COVID, conditional on getting COVID, is probably somewhere between a few tenths of a percent, and a few percent. Your chance per year of getting it by living a normal lifestyle depends on what you consider a normal lifestyle and on the future course of the pandemic. For me, under reasonable assumptions, it’s probably well below one percent. EDIT: Here are some other people who tried to do this same analysis. I learned about all of these after I wrote the first draft of this, so you can consider the basic thought process here to be independent of them - but I edited some things to account for what I learned from them before writing the final version. AcesoUnderGlass: Long COVID Is Not Necessarily Your Biggest Problem
Inline links: Lizardman, this Australian study, these people, The Dubious Origins Of Long COVID, weird x-rays, Sniffin Sticks test, somewhere between 60 and 80%, somewhere between 2x and 4x more likely, for example, the creepy shadow war between mother and fetus, Bryan Caplan, wrote, added, Preliminary Evidence On Long COVID In Children, Blankenburg et al, one of them, English team says, Here’s, the scientific paper font, This NEJM study, infection severity is linked to Long COVID risk, this study, vaccines can help relieve symptoms of existing long COVID, this essay, a writeup of this, This site says, MicroCOVID, This tracker, the BMJ, https://substackcdn.com/image/fetch/$s_!yL40!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F1eea7cfa-df08-4c67-acf2-da24ce860ae3_713x373.png, a meta-analysis by Poole-Wright et al, scattered reports, this paper, postviral syndrome
In this context, I find the 1/150 risk pretty scary and the 1/25,000 risk not scary at all, so, darn, I guess there’s not yet enough data to have a strong sense of how concerned I should be. 9. This is hard to compare to other postviral syndromes Going into this, I wondered if we might be able to ignore Long COVID. The argument would go like this: all viral diseases have a risk of postviral syndromes. Colds, flus, mono, lots of stuff that’s going around all the time. Lots of people get those postviral syndromes, and either recover or don’t, but either way we don’t make a big deal out of it. Since COVID’s considered “newsworthy” in a way flu isn’t, we obsess over its postviral syndrome even though it’s no worse than anything else’s. This wouldn’t make Long COVID any less bad, and maybe we would be wrong to not panic more about colds and the flu, but it would at least give us some context and make things feel less scary. Unfortunately, I can’t find anything supporting or opposing this picture. The only relevant study is a meta-analysis by Poole-Wright et al, who (contra nominative determinism) don’t pool the studies by condition, which makes it hard to draw conclusions. I think all of their examples of postviral syndrome after flu are from severe hospitalized cases, so any comparison with COVID would be unfair. Although there do seem to be scattered reports of post-flu problems, they’ve never been formally studied or quantified. Mononucleosis is an infectious disease caused by the Epstein-Barr virus, affecting about 1/2000 people per year in developed countries. It has a famously nasty postviral syndrome, which this paper describes as “almost one-half of the group had substantial ongoing symptoms 2 months after onset and… ∼10% had disabling symptoms marked by fatigue lasting ≥ 6 months”. Flu is as common as COVID, but nobody really talks about it having a significant postviral syndrome so probably it’s not that bad. Mono has a worse postviral syndrome than COVID, but it’s rare enough that it doesn’t cause massive society-wide effects. COVID is right in the middle: more common than mono, and (probably) worse postviral syndrome than flu. I think it’s fair to say that we may not have encountered a condition with this exact combination of risk factors and can’t dismiss it as similar to conditions we currently ignore. One potential analogue might be the Spanish Flu of 1918. It was an equally widespread pandemic, and seemed to have some kind of postviral syndrome. From TIME: In what is now Tanzania, to the north, post-viral syndrome has been blamed for triggering the worst famine in a century—the so-called “famine of corms”—after debilitating lethargy prevented flu survivors from planting when the rains came at the end of 1918. “Agriculture suffered particular disruption because, not only did the epidemic coincide with the planting season in some parts of the country, but in others it came at the time for harvesting and sheep-shearing.” Kathleen Brant, who lived on a farm in Taranaki, New Zealand, told Rice, the historian, about the “legion” problems farmers in her district encountered following the pandemic, even though all patients survived: “The effects of loss of production were felt for a long time.” The 1918 flu seemed to have lots of psychiatric effects: “Norwegian demographer Svenn-Erik Mamelund provided such evidence when he combed the records of psychiatric institutions in his country to show that the average number of admissions showed a seven-fold increase in each of the six years following the pandemic, compared to earlier, non-pandemic years.” Coronavirus doesn’t - the excellent Amin-Chowdhury study above finds nothing. Still, this is the scale of thing I’m worried about. The worst case scenario here is really really bad. If a few percent of COVID patients get long-term unremitting genuine CFS/ME, that has the potential to overwhelm government welfare budgets and long-term depress the economy. I think there’s a 90% chance the real situation isn’t that bad, but it’s scary that we can’t entirely rule it out. Aside from the somewhat different 1918 case, I don’t think we have any historical experience of dealing with postviral syndromes at this scale. The medium case scenario is something more like “a few percent of infected people get moderate fatigue, which doesn’t really prevent them from working, and goes away after a few years”. I don’t know whether the level of media attention paid to this would converge on “boring and nobody notices” or “giant disaster”, and I think it would be compatible with either. 10. Conclusions 1. Long COVID is many different issues without a common mechanism. 2. Some of these are straightforward and not surprising, eg lung scarring and post-ICU syndrome from severe infection, and would happen in any disease of this severity. Others seem to be more like the poorly-understood postviral syndromes associated with several other diseases. While some symptoms may be psychosomatic, most are probably organic. 3 The three major categories of symptoms are straightforward cardiovascular-pulmonary issues, straightforward smell and taste issues, and more mysterious neurological issues. 4 Although these get better with time in some people, in a significant number (maybe ~50% of people who had them at six weeks) they persist for as long as anyone has been able to measure them (a few months in the case of COVID, a year or two in the case of comparable syndromes). 5. Post-COVID fatigue is particularly concerning. This would be very bad if we analogized it to CFS/ME, and still pretty bad if we analogized it to other known postviral syndromes. There is no proof that this always gets better over the long term, although no study has looked at them for more than a few years. Facing postviral fatigue on this scale is a new problem. 6 . Children probably get Long COVID less than adults, probably at a rate of less than 5% of symptomatic cases. But we don’t know how much less, and we can’t rule out that some children get pretty severe symptoms. 7. Although vaccination decreases the risk of symptomatic COVID, it probably doesn’t decrease the risk of Long COVID per symptomatic COVID case by very much, though it might decrease it by a factor of 2-3. 8. Your chance of really bad debilitating lifelong Long COVID, conditional on getting COVID, is probably somewhere between a few tenths of a percent, and a few percent. Your chance per year of getting it by living a normal lifestyle depends on what you consider a normal lifestyle and on the future course of the pandemic. For me, under reasonable assumptions, it’s probably well below one percent. EDIT: Here are some other people who tried to do this same analysis. I learned about all of these after I wrote the first draft of this, so you can consider the basic thought process here to be independent of them - but I edited some things to account for what I learned from them before writing the final version. AcesoUnderGlass: Long COVID Is Not Necessarily Your Biggest Problem
Inline links: a meta-analysis by Poole-Wright et al, scattered reports, this paper, postviral syndrome, Long COVID Is Not Necessarily Your Biggest Problem
postviral syndrome1 mentions across 1 issues

postviral syndrome is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between September 02, 2021 and September 02, 2021. The archive places it in contexts such as "worse postviral syndrome than flu". It most often appears alongside 1DaySooner, AC&E, AcesoUnderGlass.

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postviral syndrome
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1
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1
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September 02, 2021
Last seen
September 02, 2021
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Long COVID: Much More Than You Wanted To Know
September 02, 2021 · Original source
This is supposedly . . . also the British Office of National Statistics (source). Why are their two graphs so different? My guess is that the top one is a preliminary version without very many patients who had COVID for longer than 12 weeks, and used some sort of model which just assumed numbers there (notice how the confidence intervals widen). The second graph better fits the studies above and is probably the real one. That’s too bad, because the second graph says that about half of people who have long COVID symptoms after five weeks will still have them after four months. And that graph doesn’t look like it’s planning on falling much further. This kind of matches Haverfall’s study, which found a decrease of a little less than half between two and eight months. There is a very long tail of cases which are not getting better in a reasonable amount of time. The most likely symptom to last a long time is anosmia, followed by fatigue. How likely are these to last forever vs. get better in a few years? We’ve only had a year and a half of COVID, but we can make guesses based on other postviral syndromes. Lee et al do this work with 63 patients over three years, and find: There’s a lot going on here. First of all, how come the severe hyposmia group starts with about the same scores as the mild-to-moderate group? I think because they classified severity objectively, and this is measuring subjective scores? Anyhow, almost everyone improves over this time period, but not everyone reaches normality (defined as a score of 80 or above). This is kind of useless because the study doesn’t tell us how much of this improvement was the first year vs. the second and so on, so we don’t know if improvements petered off or will continue forever. It does mention that people with followup longer than 2 years did better than people with shorter followup than that, but honestly I can’t conclude anything useful from this and there are no better studies. What about fatigue? It turns out that chronic fatigue syndrome patients care a lot about this question and so there are great data. From ME-Pedia: This is terrible. Recovery rates in the single digit percentages over the space of years. You would think at least some patients would get placebo recoveries, or forget how it felt to be well, or otherwise Lizardman themselves into fake complacency, but no. This is f@#$ing awful. Maybe COVID won’t be this bad? One ray of hope comes from this Australian study, where doctors record the rates of recovery from postviral fatigue after various rare diseases they encounter (Epstein-Barr, Q fever, Ross River virus). They find that 35% of these patients have postviral fatigue after six weeks, but only 12% after six months, and 9% after twelve months. This sounds a lot better than chronic fatigue. In fact, these people do the kind of weird task of figuring out how bad different diagnostic labels for fatigue are, even though some might argue that all the labels refer to the same underlying reality. They find an official diagnosis of “CFS/ME” (chronic fatigue / myalgic encephalitis) is much worse than “postviral fatigue”. Using the weird measure of “days per year of followup with diagnosis” (I’m not sure I fully understand their reasoning for why this is good), they find a median length of 80 for CFS/ME vs. 0 for PVF (…huh?). Using the more comprehensible measure of percent who still complain of fatigue after 7-12 months, they find it’s 24% vs. 10% (which super contradicts the above study saying that basically nobody with a CFS/ME diagnosis ever recovers). My guess is that this study had much lower criteria for a CFS/ME diagnosis (some doctor diagnosed it and put it on the insurance records) compared to the ones above (some specialist confirmed it by official criteria). The conclusion I draw is that, while official CFS/ME is horrible and hopeless, there are a lot of things that unofficially look kind of chronic-fatigue-ish which have pretty good prognoses. Since there’s no good reason to think post-COVID fatigue is official CFS/ME as opposed to just some chronic-ish fatigue-ish thing, probably it will have a better prognosis, more like weird Australian viruses. …which we still don’t know, because AFAICT nobody has done any good studies on postviral fatigue lasting more than a year. 5. Psychosomatic symptoms probably aren’t the majority of long COVID. I mean, I’m not seeing too many people claiming that they are. There are a lot more people worried that someone else might be claiming that, than people actually making the claim. Still, the Wall Street Journal opinion section is always up for slathering itself in glue and rolling around in a haystack until it becomes the straw man everyone else warned you about, and they do have an article on The Dubious Origins Of Long COVID. They point out that long COVID was first thrust into the public consciousness in surveys run by Body Politic, who self-describe as “a queer feminist wellness collective merging the personal and the political”. I agree this is a weird source for something to come from, but Hans Asperger was a Nazi and I still use his diagnosis, so I probably have to accept these people’s as well. More relevantly, WSJ points out that many of the people complaining of Long COVID symptoms test negative for COVID, or at least never tested positive. This complaint conflates the fact that not everyone was able to get a COVID test at all, with the fact that sometimes you get the acute COVID test after you’ve recovered from acute COVID and it’s negative, with the fact that COVID tests don’t have a 100% success rate, with the fact that yeah, okay, some people who didn’t have COVID are probably imagining Long COVID symptoms. I feel like some of the case-control studies above, which clearly show that seropositive people have higher rates of Long COVID than seronegative people, are pretty convincing here. But also - the people with lung scarring clearly have lung scarring, and most of them have weird x-rays consistent with lung scarring. If you have lung scarring, then you have trouble breathing, you’re fatigued, and you probably have lots of other stuff downstream of that. The people with smell/taste disturbances clearly have smell/taste disturbances, testable with the stupidly named but scientifically venerable Sniffin Sticks test - and also, who even cares enough to make up olfactory problems? Fatigue and brain fog are the only symptoms here that can’t be easily objectively confirmed, and, well, do you think those Australians who got infected with Q fever and had twelve months of postviral fatigue are faking? What about all those post-Epstein Barr fatigue people? Lots of viruses cause postviral fatigue, it’s not really surprising that COVID should also. (WSJ also spends a while arguing that CFS/ME is just a psychiatric disorder, which I think is not really in keeping with the best recent evidence. Also, as a psychiatrist, I’m very against this conclusion, mostly because if it were true, then people would expect me to cure CFS/ME patients.) One point WSJ didn’t bring up but could have was that most Long COVID patients are women. Probably this is somewhere between 60 and 80% - I suspect on the lower end of this, because I think women are more likely to talk about these kinds of things than men, and much more likely to eg join Facebook groups. This is noteworthy, because women are traditionally more prone to psychosomatic illnesses - so much that the ancients attributed these to the uterus and called them hysteria (note shared root with eg “hysterectomy”). Women are about 2x as likely to get diagnosed with panic disorder, anxiety disorders, phobias, etc, about 2.5x as likely to get chronic Lyme disease, widely regarded as an entirely psychosomatic condition, and 3-5x more likely to be diagnosed with fibromyalgia. So the female preponderance is suspicious. But women are also somewhere between 2x and 4x more likely to get autoimmune disorders than men (it varies by disorder - the ratio for Sjogren’s is as high as 16x). There are some pretty crazy hypotheses for why this is - for example, maybe women’s immune systems are permanently upregulated to be prepared for attempts by the placenta to secrete immune-downregulating chemicals during pregnancy, as part of the creepy shadow war between mother and fetus to regulate the maternal environment. I don’t know, do you have a better idea? Anyway, women have more autoimmune issues and more upregulated immune systems, so if there was any good way to assess gender ratio in true postviral fatigue excluding all psychosomatic cases, that would probably be female-biased too. Probably some Long COVID cases are psychosomatic just like some cases of anything are psychosomatic, but I don’t see too many signs that this is too important in explaining the phenomenon. …and please allow me a moment of preachiness here. Chronic fatigue sounds really fake to anyone who doesn’t have it. I think this is because it’s related to willpower. Willpower itself would sound fake to anyone who didn’t have to worry about it. “Oh, so you can go partying with your friends whenever you want, but as soon as it comes time to write a ten page report, your ‘lack of willpower’ prevents you from doing it? A likely story!” Still, all of us (except Bryan Caplan) recognize how real and important willpower is - how having more of it is better than having less of it, and how some condition that caused you to have pathologically little of it would be a huge disaster. In the comments section to the rough draft of this post, CJ wrote: I will say - I was one of those types of men to scoff with skepticism at people claiming to have chronic fatigue and the like. I would have called those people lazy and would have been adamant they were faking it or feeling like crap because of unhealthy lifestyle choices. Unfortunately I have learned the hard way the severity of neurological conditions, what it feels like to have brain fog, what chronic fatigue feels like, and how difficult it can be to communicate neurological symptoms to others. I now start from a position of listening to people who are willing to open up about their symptoms and trust that they are being honest. There are millions of people suffering in silence with untreated and undiagnosed disorders - those people are not all faking it or just dealing with psychosomatic conditions. I would recommend Jennifer Brea's documentary, Unrest. Thank you for shedding some light on the subject. Heron added: I second the suggestion to watch 'Unrest,' and to consider the many unseen ill whose symptoms are deemed to be imagined. Until this last year, I had little patience with, and doubted, people who I saw as hypochondriacs. Then I became the thing I hated. Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Long COVID do have similarities from what I've read, since becoming ill in August 2020. At that time, here in Northern Ireland, there was scant availability of COVID tests; after spending three days trying to get hold of one, (by which time I'd stopped teaching my post-grad online classes & I haven't worked since) I became too ill to do anything. I figured if this was COVID I'd gotten off lightly, mostly constant severe headache, inability to think, a new experience of fatigue, high temperature, insomnia, hypersomnia, paresthesia, no smell or taste etc Debilitated but not dead. Except for the fact that I still have the aforementioned symptoms a year on and whilst they fluctuate in type and severity, the fatigue, headaches and cognitive difficulties are real. A brain scan, an appointment for brain and spinal MRIs (waiting lists, even when going private [as NHS has 3-8 yr waiting lists here in NI] are lengthy), rare virtual doctors and neurologists suggest my ailments constitute a post-viral thing, maybe Long C, they can offer nothing but pills for pain. There is no test for ME/CFS yet, nor a Long C test, symptoms and presentation are so varied. Given a widespread lack of knowledge and resources regarding these ailments, you're on your own. Maybe I've developed ME, I certainly have post-exertional malaise which my very prominent neurologist hadn't heard of. Looking at the history of ME/CFS* and a dearth of research surrounding it, I hope that rather than dismiss the lives of sufferers of this or the long-lasting aftermath of COVID, that those experiencing such difficulties will be heard and learnt from. I only understood when I had no alternative. I don’t think I ever actively pooh-poohed CFS, but like everyone else who encountered it, I underestimated just how bad it was until I met some patients with the condition. It is real and really bad. For whatever reason it is hard to think about and take seriously, but it really is as bad as people say. </preachiness> 6. Long COVID is probably rare in children This matters a lot, because children are (currently) ineligible for the vaccine, and also likely to encounter the virus at school. But children usually have mild cases of COVID and don’t die from it, so it’s tempting to just not worry about them. But if they could get Long COVID, that would make it much less tempting. Preliminary Evidence On Long COVID In Children sounds like a good paper to draw conclusions from. It says 42.6% of children with COVID experience long-term follow-up symptoms, which would be higher than the rate for adults. But it has no control group, and most of the symptoms it finds don’t seem very COVID-related (eg rashes, constipation). The most common symptom (20%) is insomnia, which better studies in adults fail to associate with real Long COVID. The rate of known long COVID symptoms (eg taste and smell problems) is only about 3-4%, and no higher or lower than anything else. Probably these kids are just having problems at the usual rate and attributing them to their recent COVID. Blankenburg et al do the correct thing and ask a thousand children about potential symptoms, then compare the number who say yes vs. no among COVID-seropositive and seronegative subjects. They find no difference between the two groups. Both are reporting a lot of insomnia, etc. They reasonably attribute this to pandemics being a stressful event that it’s natural to lose sleep over. This is really reassuring, but it can’t rule out a somewhat rarer syndrome. The authors say that they might miss symptoms with a prevalence of less than 10%, and one of them gives his own personal guess that it’s 1%. An English team says there’s a Long COVID rate of 4.6% in kids. But there was a 1.7% rate of similar symptoms in the control group of kids who didn’t have COVID, so I think it would be fair to subtract that and end up with 2.9%. And even though the study started with 5000 children, so few of them got COVID, and so few of those got long COVID, that the 2.9% turns out to be about five kids. I don’t really want to update too much based on five kids, especially given the risk of recall bias (ie you might notice / care about your symptoms more if you know you had COVID before getting them). My overall conclusion here is that long COVID is rarer in children than adults, and may not exist at all. The studies tell us it’s probably somewhere less than 5% of kids, but so far we can’t conclude anything stronger than that. 7. Vaccination probably doesn’t change the per-symptomatic-case risk of Long COVID much Here’s a complicated Twitter thread about this. Of vaccinated people who got symptomatic COVID, about a third ended up with Long COVID symptoms, the same rate as in unvaccinated people. Of course, vaccinated people are much less likely to get symptomatic COVID. But even conditional on getting it, they’re still much less likely to go to the hospital, die, etc. It would have been nice if the same was true of getting Long COVID. But it doesn’t look that way. (all this information is from an online poll by a sketchy group of COVID “survivor” activists. But they wrote up their poll in the scientific paper font, as a PDF and everything, so I say we count it anyway) This NEJM study wasn’t exactly designed to look for Long COVID in vaccinated people. But they found it anyway, at a rate of 19% after 6 weeks. This also fits within the (wide) range reported for unvaccinated people. They don’t give a symptom breakdown beyond “prolonged loss of smell, persistent cough, fatigue, weakness, dyspnea, or myalgia”, which sounds like the usual set. These studies are pretty weak, and you could argue that given that vaccines decrease the average severity of COVID infection, and infection severity is linked to Long COVID risk, we should have a strong prior on vaccines decreasing Long COVID risk. And just before publishing this, someone sent me this study, which very preliminarily finds vaccines might decrease Long COVID risk by a factor of 2. I think a factor of 2-3 is believable; one of 10 or 20, less so. Weirdly, there are some claims that vaccines can help relieve symptoms of existing long COVID. Sounds kind of like sympathetic magic to me, but the researcher quoted in the linked article said it might “improve symptoms by eliminating any virus or viral remnants left in the body” or by “rebalancing the immune system”. So yeah, sympathetic magic. 8. Your risk of a terrible long COVID outcome conditional on COVID is probably between a few tenths of a percent and a few percent. My original calculation went like this: About 25% of people who get COVID report long COVID symptoms. About half of those go away after a few months, so 12.5% get persistent symptoms. Suppose that half of those cases (totally made-up number) are very mild and not worth worrying about. Then 6.25% of people who get COVID would have serious long-lasting Long COVID symptoms. After doing that calculation, I read this essay by Matt Bell, who tries to figure out the same thing. He is much more optimistic. He agrees that about half of long COVID cases go away after a few months, but adds another 50% decrease from “few months” to “lifelong”, kind of on priors, admitting there’s not too much positive evidence for this. Then he adds another factor-of-two decrease from vaccination, based on very preliminary studies from the UK. He estimates that someone with my demographics (vaccinated man in his 30s) has a 2% risk of Long COVID conditional on getting COVID at all. Then he divides by five for the true worst case scenario, based on studies showing that a fifth of people with Long COVID report that it affects their daily activities “a lot”. So by his final number, I have an 0.4% chance of getting really terrible long COVID, conditional on getting COVID at all. My friend AcesoUnderGlass also did a writeup of this, published after I did my first-draft calculation, which seems to be thinking of this very differently, based entirely on hospitalization rates (which of course are very low in vaccinated people our age). She accordingly concludes that risk is very low. I don’t really understand her reasoning here, but I trust her a lot and am working on trying to converge with her on this. What’s my yearly risk of getting COVID if I try to live a normal life? This site says only 0.1% of vaccinated Californians have gotten COVID after their vaccination. But vaccination was pretty new when that survey was done, so we might want to take this as a per one-to-two-months estimate. That would mean a risk of 0.5 - 1 percent per year. But not all these people are living normal lives, so my risk might be higher. MicroCOVID gives me a good sense of how careful I’d have to be to stay within a risk budget of 1% COVID risk per year. When I play around with it, I think I am about 5x - 10x less careful than that, which would mean a risk of about 5%/year. This tracker suggests my area has recently had about 1 new case per thousand people per week, which would imply 5% per year. But most of those people are probably unvaccinated, so my risk would be significantly lower than that. I’m going to round all of this off to about 1% - 10% per year of getting a breakthrough COVID case (though obviously this could change if the national picture got better or worse). Combined with the 0.4% to 6.25% risk of getting terrible long COVID conditional on getting COVID, that’s between a 1/150 - 1/25,000 chance of terrible long COVID per year. How does this compare to other risks? My ordinary risk of death per year, just from being a man in his 30s, is about 1/700 (though this includes drug abusers and stunt pilots, so my real risk might be lower, let’s say 1/1000). Here are some other risks, courtesy of the BMJ: In this context, I find the 1/150 risk pretty scary and the 1/25,000 risk not scary at all, so, darn, I guess there’s not yet enough data to have a strong sense of how concerned I should be. 9. This is hard to compare to other postviral syndromes Going into this, I wondered if we might be able to ignore Long COVID. The argument would go like this: all viral diseases have a risk of postviral syndromes. Colds, flus, mono, lots of stuff that’s going around all the time. Lots of people get those postviral syndromes, and either recover or don’t, but either way we don’t make a big deal out of it. Since COVID’s considered “newsworthy” in a way flu isn’t, we obsess over its postviral syndrome even though it’s no worse than anything else’s. This wouldn’t make Long COVID any less bad, and maybe we would be wrong to not panic more about colds and the flu, but it would at least give us some context and make things feel less scary. Unfortunately, I can’t find anything supporting or opposing this picture. The only relevant study is a meta-analysis by Poole-Wright et al, who (contra nominative determinism) don’t pool the studies by condition, which makes it hard to draw conclusions. I think all of their examples of postviral syndrome after flu are from severe hospitalized cases, so any comparison with COVID would be unfair. Although there do seem to be scattered reports of post-flu problems, they’ve never been formally studied or quantified. Mononucleosis is an infectious disease caused by the Epstein-Barr virus, affecting about 1/2000 people per year in developed countries. It has a famously nasty postviral syndrome, which this paper describes as “almost one-half of the group had substantial ongoing symptoms 2 months after onset and… ∼10% had disabling symptoms marked by fatigue lasting ≥ 6 months”. Flu is as common as COVID, but nobody really talks about it having a significant postviral syndrome so probably it’s not that bad. Mono has a worse postviral syndrome than COVID, but it’s rare enough that it doesn’t cause massive society-wide effects. COVID is right in the middle: more common than mono, and (probably) worse postviral syndrome than flu. I think it’s fair to say that we may not have encountered a condition with this exact combination of risk factors and can’t dismiss it as similar to conditions we currently ignore. One potential analogue might be the Spanish Flu of 1918. It was an equally widespread pandemic, and seemed to have some kind of postviral syndrome. From TIME: In what is now Tanzania, to the north, post-viral syndrome has been blamed for triggering the worst famine in a century—the so-called “famine of corms”—after debilitating lethargy prevented flu survivors from planting when the rains came at the end of 1918. “Agriculture suffered particular disruption because, not only did the epidemic coincide with the planting season in some parts of the country, but in others it came at the time for harvesting and sheep-shearing.” Kathleen Brant, who lived on a farm in Taranaki, New Zealand, told Rice, the historian, about the “legion” problems farmers in her district encountered following the pandemic, even though all patients survived: “The effects of loss of production were felt for a long time.” The 1918 flu seemed to have lots of psychiatric effects: “Norwegian demographer Svenn-Erik Mamelund provided such evidence when he combed the records of psychiatric institutions in his country to show that the average number of admissions showed a seven-fold increase in each of the six years following the pandemic, compared to earlier, non-pandemic years.” Coronavirus doesn’t - the excellent Amin-Chowdhury study above finds nothing. Still, this is the scale of thing I’m worried about. The worst case scenario here is really really bad. If a few percent of COVID patients get long-term unremitting genuine CFS/ME, that has the potential to overwhelm government welfare budgets and long-term depress the economy. I think there’s a 90% chance the real situation isn’t that bad, but it’s scary that we can’t entirely rule it out. Aside from the somewhat different 1918 case, I don’t think we have any historical experience of dealing with postviral syndromes at this scale. The medium case scenario is something more like “a few percent of infected people get moderate fatigue, which doesn’t really prevent them from working, and goes away after a few years”. I don’t know whether the level of media attention paid to this would converge on “boring and nobody notices” or “giant disaster”, and I think it would be compatible with either. 10. Conclusions 1. Long COVID is many different issues without a common mechanism. 2. Some of these are straightforward and not surprising, eg lung scarring and post-ICU syndrome from severe infection, and would happen in any disease of this severity. Others seem to be more like the poorly-understood postviral syndromes associated with several other diseases. While some symptoms may be psychosomatic, most are probably organic. 3 The three major categories of symptoms are straightforward cardiovascular-pulmonary issues, straightforward smell and taste issues, and more mysterious neurological issues. 4 Although these get better with time in some people, in a significant number (maybe ~50% of people who had them at six weeks) they persist for as long as anyone has been able to measure them (a few months in the case of COVID, a year or two in the case of comparable syndromes). 5. Post-COVID fatigue is particularly concerning. This would be very bad if we analogized it to CFS/ME, and still pretty bad if we analogized it to other known postviral syndromes. There is no proof that this always gets better over the long term, although no study has looked at them for more than a few years. Facing postviral fatigue on this scale is a new problem. 6 . Children probably get Long COVID less than adults, probably at a rate of less than 5% of symptomatic cases. But we don’t know how much less, and we can’t rule out that some children get pretty severe symptoms. 7. Although vaccination decreases the risk of symptomatic COVID, it probably doesn’t decrease the risk of Long COVID per symptomatic COVID case by very much, though it might decrease it by a factor of 2-3. 8. Your chance of really bad debilitating lifelong Long COVID, conditional on getting COVID, is probably somewhere between a few tenths of a percent, and a few percent. Your chance per year of getting it by living a normal lifestyle depends on what you consider a normal lifestyle and on the future course of the pandemic. For me, under reasonable assumptions, it’s probably well below one percent. EDIT: Here are some other people who tried to do this same analysis. I learned about all of these after I wrote the first draft of this, so you can consider the basic thought process here to be independent of them - but I edited some things to account for what I learned from them before writing the final version. AcesoUnderGlass: Long COVID Is Not Necessarily Your Biggest Problem
Inline links: source, 63 patients over three years, https://substackcdn.com/image/fetch/$s_!TUEK!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2Fec23b8cd-a86e-4bb2-906b-b406b3000248_896x569.png, ME-Pedia, https://substackcdn.com/image/fetch/$s_!ldiD!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2Fa4352e07-08e4-4e08-8a9e-6d2752dcc491_1208x565.png, Lizardman, this Australian study, these people, The Dubious Origins Of Long COVID, weird x-rays, Sniffin Sticks test, somewhere between 60 and 80%, somewhere between 2x and 4x more likely, for example, the creepy shadow war between mother and fetus, Bryan Caplan, wrote, added, Preliminary Evidence On Long COVID In Children, Blankenburg et al, one of them, English team says, Here’s, the scientific paper font, This NEJM study, infection severity is linked to Long COVID risk, this study, vaccines can help relieve symptoms of existing long COVID, this essay, a writeup of this, This site says, MicroCOVID, This tracker, the BMJ, https://substackcdn.com/image/fetch/$s_!yL40!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F1eea7cfa-df08-4c67-acf2-da24ce860ae3_713x373.png, a meta-analysis by Poole-Wright et al, scattered reports, this paper, postviral syndrome
In this context, I find the 1/150 risk pretty scary and the 1/25,000 risk not scary at all, so, darn, I guess there’s not yet enough data to have a strong sense of how concerned I should be. 9. This is hard to compare to other postviral syndromes Going into this, I wondered if we might be able to ignore Long COVID. The argument would go like this: all viral diseases have a risk of postviral syndromes. Colds, flus, mono, lots of stuff that’s going around all the time. Lots of people get those postviral syndromes, and either recover or don’t, but either way we don’t make a big deal out of it. Since COVID’s considered “newsworthy” in a way flu isn’t, we obsess over its postviral syndrome even though it’s no worse than anything else’s. This wouldn’t make Long COVID any less bad, and maybe we would be wrong to not panic more about colds and the flu, but it would at least give us some context and make things feel less scary. Unfortunately, I can’t find anything supporting or opposing this picture. The only relevant study is a meta-analysis by Poole-Wright et al, who (contra nominative determinism) don’t pool the studies by condition, which makes it hard to draw conclusions. I think all of their examples of postviral syndrome after flu are from severe hospitalized cases, so any comparison with COVID would be unfair. Although there do seem to be scattered reports of post-flu problems, they’ve never been formally studied or quantified. Mononucleosis is an infectious disease caused by the Epstein-Barr virus, affecting about 1/2000 people per year in developed countries. It has a famously nasty postviral syndrome, which this paper describes as “almost one-half of the group had substantial ongoing symptoms 2 months after onset and… ∼10% had disabling symptoms marked by fatigue lasting ≥ 6 months”. Flu is as common as COVID, but nobody really talks about it having a significant postviral syndrome so probably it’s not that bad. Mono has a worse postviral syndrome than COVID, but it’s rare enough that it doesn’t cause massive society-wide effects. COVID is right in the middle: more common than mono, and (probably) worse postviral syndrome than flu. I think it’s fair to say that we may not have encountered a condition with this exact combination of risk factors and can’t dismiss it as similar to conditions we currently ignore. One potential analogue might be the Spanish Flu of 1918. It was an equally widespread pandemic, and seemed to have some kind of postviral syndrome. From TIME: In what is now Tanzania, to the north, post-viral syndrome has been blamed for triggering the worst famine in a century—the so-called “famine of corms”—after debilitating lethargy prevented flu survivors from planting when the rains came at the end of 1918. “Agriculture suffered particular disruption because, not only did the epidemic coincide with the planting season in some parts of the country, but in others it came at the time for harvesting and sheep-shearing.” Kathleen Brant, who lived on a farm in Taranaki, New Zealand, told Rice, the historian, about the “legion” problems farmers in her district encountered following the pandemic, even though all patients survived: “The effects of loss of production were felt for a long time.” The 1918 flu seemed to have lots of psychiatric effects: “Norwegian demographer Svenn-Erik Mamelund provided such evidence when he combed the records of psychiatric institutions in his country to show that the average number of admissions showed a seven-fold increase in each of the six years following the pandemic, compared to earlier, non-pandemic years.” Coronavirus doesn’t - the excellent Amin-Chowdhury study above finds nothing. Still, this is the scale of thing I’m worried about. The worst case scenario here is really really bad. If a few percent of COVID patients get long-term unremitting genuine CFS/ME, that has the potential to overwhelm government welfare budgets and long-term depress the economy. I think there’s a 90% chance the real situation isn’t that bad, but it’s scary that we can’t entirely rule it out. Aside from the somewhat different 1918 case, I don’t think we have any historical experience of dealing with postviral syndromes at this scale. The medium case scenario is something more like “a few percent of infected people get moderate fatigue, which doesn’t really prevent them from working, and goes away after a few years”. I don’t know whether the level of media attention paid to this would converge on “boring and nobody notices” or “giant disaster”, and I think it would be compatible with either. 10. Conclusions 1. Long COVID is many different issues without a common mechanism. 2. Some of these are straightforward and not surprising, eg lung scarring and post-ICU syndrome from severe infection, and would happen in any disease of this severity. Others seem to be more like the poorly-understood postviral syndromes associated with several other diseases. While some symptoms may be psychosomatic, most are probably organic. 3 The three major categories of symptoms are straightforward cardiovascular-pulmonary issues, straightforward smell and taste issues, and more mysterious neurological issues. 4 Although these get better with time in some people, in a significant number (maybe ~50% of people who had them at six weeks) they persist for as long as anyone has been able to measure them (a few months in the case of COVID, a year or two in the case of comparable syndromes). 5. Post-COVID fatigue is particularly concerning. This would be very bad if we analogized it to CFS/ME, and still pretty bad if we analogized it to other known postviral syndromes. There is no proof that this always gets better over the long term, although no study has looked at them for more than a few years. Facing postviral fatigue on this scale is a new problem. 6 . Children probably get Long COVID less than adults, probably at a rate of less than 5% of symptomatic cases. But we don’t know how much less, and we can’t rule out that some children get pretty severe symptoms. 7. Although vaccination decreases the risk of symptomatic COVID, it probably doesn’t decrease the risk of Long COVID per symptomatic COVID case by very much, though it might decrease it by a factor of 2-3. 8. Your chance of really bad debilitating lifelong Long COVID, conditional on getting COVID, is probably somewhere between a few tenths of a percent, and a few percent. Your chance per year of getting it by living a normal lifestyle depends on what you consider a normal lifestyle and on the future course of the pandemic. For me, under reasonable assumptions, it’s probably well below one percent. EDIT: Here are some other people who tried to do this same analysis. I learned about all of these after I wrote the first draft of this, so you can consider the basic thought process here to be independent of them - but I edited some things to account for what I learned from them before writing the final version. AcesoUnderGlass: Long COVID Is Not Necessarily Your Biggest Problem
Inline links: a meta-analysis by Poole-Wright et al, scattered reports, this paper, postviral syndrome, Long COVID Is Not Necessarily Your Biggest Problem
postviral syndromes1 mentions across 1 issues

postviral syndromes is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between September 02, 2021 and September 02, 2021. The archive places it in contexts such as "risk of postviral syndromes". It most often appears alongside 1DaySooner, AC&E, AcesoUnderGlass.

Reference entry
postviral syndromes
Mention count
1
Issue count
1
First seen
September 02, 2021
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Long COVID: Much More Than You Wanted To Know
September 02, 2021 · Original source
Fourth, COVID can probably cause a post-viral syndrome including fatigue. Post-viral syndromes are poorly understood, but might involve something like the immune system being dysregulated and staying in “fight mode” long after the virus is gone. “Chronic fatigue syndrome” is probably something like this, although this is still really controversial.
This is supposedly . . . also the British Office of National Statistics (source). Why are their two graphs so different? My guess is that the top one is a preliminary version without very many patients who had COVID for longer than 12 weeks, and used some sort of model which just assumed numbers there (notice how the confidence intervals widen). The second graph better fits the studies above and is probably the real one. That’s too bad, because the second graph says that about half of people who have long COVID symptoms after five weeks will still have them after four months. And that graph doesn’t look like it’s planning on falling much further. This kind of matches Haverfall’s study, which found a decrease of a little less than half between two and eight months. There is a very long tail of cases which are not getting better in a reasonable amount of time. The most likely symptom to last a long time is anosmia, followed by fatigue. How likely are these to last forever vs. get better in a few years? We’ve only had a year and a half of COVID, but we can make guesses based on other postviral syndromes. Lee et al do this work with 63 patients over three years, and find: There’s a lot going on here. First of all, how come the severe hyposmia group starts with about the same scores as the mild-to-moderate group? I think because they classified severity objectively, and this is measuring subjective scores? Anyhow, almost everyone improves over this time period, but not everyone reaches normality (defined as a score of 80 or above). This is kind of useless because the study doesn’t tell us how much of this improvement was the first year vs. the second and so on, so we don’t know if improvements petered off or will continue forever. It does mention that people with followup longer than 2 years did better than people with shorter followup than that, but honestly I can’t conclude anything useful from this and there are no better studies. What about fatigue? It turns out that chronic fatigue syndrome patients care a lot about this question and so there are great data. From ME-Pedia: This is terrible. Recovery rates in the single digit percentages over the space of years. You would think at least some patients would get placebo recoveries, or forget how it felt to be well, or otherwise Lizardman themselves into fake complacency, but no. This is f@#$ing awful. Maybe COVID won’t be this bad? One ray of hope comes from this Australian study, where doctors record the rates of recovery from postviral fatigue after various rare diseases they encounter (Epstein-Barr, Q fever, Ross River virus). They find that 35% of these patients have postviral fatigue after six weeks, but only 12% after six months, and 9% after twelve months. This sounds a lot better than chronic fatigue. In fact, these people do the kind of weird task of figuring out how bad different diagnostic labels for fatigue are, even though some might argue that all the labels refer to the same underlying reality. They find an official diagnosis of “CFS/ME” (chronic fatigue / myalgic encephalitis) is much worse than “postviral fatigue”. Using the weird measure of “days per year of followup with diagnosis” (I’m not sure I fully understand their reasoning for why this is good), they find a median length of 80 for CFS/ME vs. 0 for PVF (…huh?). Using the more comprehensible measure of percent who still complain of fatigue after 7-12 months, they find it’s 24% vs. 10% (which super contradicts the above study saying that basically nobody with a CFS/ME diagnosis ever recovers). My guess is that this study had much lower criteria for a CFS/ME diagnosis (some doctor diagnosed it and put it on the insurance records) compared to the ones above (some specialist confirmed it by official criteria). The conclusion I draw is that, while official CFS/ME is horrible and hopeless, there are a lot of things that unofficially look kind of chronic-fatigue-ish which have pretty good prognoses. Since there’s no good reason to think post-COVID fatigue is official CFS/ME as opposed to just some chronic-ish fatigue-ish thing, probably it will have a better prognosis, more like weird Australian viruses. …which we still don’t know, because AFAICT nobody has done any good studies on postviral fatigue lasting more than a year. 5. Psychosomatic symptoms probably aren’t the majority of long COVID. I mean, I’m not seeing too many people claiming that they are. There are a lot more people worried that someone else might be claiming that, than people actually making the claim. Still, the Wall Street Journal opinion section is always up for slathering itself in glue and rolling around in a haystack until it becomes the straw man everyone else warned you about, and they do have an article on The Dubious Origins Of Long COVID. They point out that long COVID was first thrust into the public consciousness in surveys run by Body Politic, who self-describe as “a queer feminist wellness collective merging the personal and the political”. I agree this is a weird source for something to come from, but Hans Asperger was a Nazi and I still use his diagnosis, so I probably have to accept these people’s as well. More relevantly, WSJ points out that many of the people complaining of Long COVID symptoms test negative for COVID, or at least never tested positive. This complaint conflates the fact that not everyone was able to get a COVID test at all, with the fact that sometimes you get the acute COVID test after you’ve recovered from acute COVID and it’s negative, with the fact that COVID tests don’t have a 100% success rate, with the fact that yeah, okay, some people who didn’t have COVID are probably imagining Long COVID symptoms. I feel like some of the case-control studies above, which clearly show that seropositive people have higher rates of Long COVID than seronegative people, are pretty convincing here. But also - the people with lung scarring clearly have lung scarring, and most of them have weird x-rays consistent with lung scarring. If you have lung scarring, then you have trouble breathing, you’re fatigued, and you probably have lots of other stuff downstream of that. The people with smell/taste disturbances clearly have smell/taste disturbances, testable with the stupidly named but scientifically venerable Sniffin Sticks test - and also, who even cares enough to make up olfactory problems? Fatigue and brain fog are the only symptoms here that can’t be easily objectively confirmed, and, well, do you think those Australians who got infected with Q fever and had twelve months of postviral fatigue are faking? What about all those post-Epstein Barr fatigue people? Lots of viruses cause postviral fatigue, it’s not really surprising that COVID should also. (WSJ also spends a while arguing that CFS/ME is just a psychiatric disorder, which I think is not really in keeping with the best recent evidence. Also, as a psychiatrist, I’m very against this conclusion, mostly because if it were true, then people would expect me to cure CFS/ME patients.) One point WSJ didn’t bring up but could have was that most Long COVID patients are women. Probably this is somewhere between 60 and 80% - I suspect on the lower end of this, because I think women are more likely to talk about these kinds of things than men, and much more likely to eg join Facebook groups. This is noteworthy, because women are traditionally more prone to psychosomatic illnesses - so much that the ancients attributed these to the uterus and called them hysteria (note shared root with eg “hysterectomy”). Women are about 2x as likely to get diagnosed with panic disorder, anxiety disorders, phobias, etc, about 2.5x as likely to get chronic Lyme disease, widely regarded as an entirely psychosomatic condition, and 3-5x more likely to be diagnosed with fibromyalgia. So the female preponderance is suspicious. But women are also somewhere between 2x and 4x more likely to get autoimmune disorders than men (it varies by disorder - the ratio for Sjogren’s is as high as 16x). There are some pretty crazy hypotheses for why this is - for example, maybe women’s immune systems are permanently upregulated to be prepared for attempts by the placenta to secrete immune-downregulating chemicals during pregnancy, as part of the creepy shadow war between mother and fetus to regulate the maternal environment. I don’t know, do you have a better idea? Anyway, women have more autoimmune issues and more upregulated immune systems, so if there was any good way to assess gender ratio in true postviral fatigue excluding all psychosomatic cases, that would probably be female-biased too. Probably some Long COVID cases are psychosomatic just like some cases of anything are psychosomatic, but I don’t see too many signs that this is too important in explaining the phenomenon. …and please allow me a moment of preachiness here. Chronic fatigue sounds really fake to anyone who doesn’t have it. I think this is because it’s related to willpower. Willpower itself would sound fake to anyone who didn’t have to worry about it. “Oh, so you can go partying with your friends whenever you want, but as soon as it comes time to write a ten page report, your ‘lack of willpower’ prevents you from doing it? A likely story!” Still, all of us (except Bryan Caplan) recognize how real and important willpower is - how having more of it is better than having less of it, and how some condition that caused you to have pathologically little of it would be a huge disaster. In the comments section to the rough draft of this post, CJ wrote: I will say - I was one of those types of men to scoff with skepticism at people claiming to have chronic fatigue and the like. I would have called those people lazy and would have been adamant they were faking it or feeling like crap because of unhealthy lifestyle choices. Unfortunately I have learned the hard way the severity of neurological conditions, what it feels like to have brain fog, what chronic fatigue feels like, and how difficult it can be to communicate neurological symptoms to others. I now start from a position of listening to people who are willing to open up about their symptoms and trust that they are being honest. There are millions of people suffering in silence with untreated and undiagnosed disorders - those people are not all faking it or just dealing with psychosomatic conditions. I would recommend Jennifer Brea's documentary, Unrest. Thank you for shedding some light on the subject. Heron added: I second the suggestion to watch 'Unrest,' and to consider the many unseen ill whose symptoms are deemed to be imagined. Until this last year, I had little patience with, and doubted, people who I saw as hypochondriacs. Then I became the thing I hated. Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Long COVID do have similarities from what I've read, since becoming ill in August 2020. At that time, here in Northern Ireland, there was scant availability of COVID tests; after spending three days trying to get hold of one, (by which time I'd stopped teaching my post-grad online classes & I haven't worked since) I became too ill to do anything. I figured if this was COVID I'd gotten off lightly, mostly constant severe headache, inability to think, a new experience of fatigue, high temperature, insomnia, hypersomnia, paresthesia, no smell or taste etc Debilitated but not dead. Except for the fact that I still have the aforementioned symptoms a year on and whilst they fluctuate in type and severity, the fatigue, headaches and cognitive difficulties are real. A brain scan, an appointment for brain and spinal MRIs (waiting lists, even when going private [as NHS has 3-8 yr waiting lists here in NI] are lengthy), rare virtual doctors and neurologists suggest my ailments constitute a post-viral thing, maybe Long C, they can offer nothing but pills for pain. There is no test for ME/CFS yet, nor a Long C test, symptoms and presentation are so varied. Given a widespread lack of knowledge and resources regarding these ailments, you're on your own. Maybe I've developed ME, I certainly have post-exertional malaise which my very prominent neurologist hadn't heard of. Looking at the history of ME/CFS* and a dearth of research surrounding it, I hope that rather than dismiss the lives of sufferers of this or the long-lasting aftermath of COVID, that those experiencing such difficulties will be heard and learnt from. I only understood when I had no alternative. I don’t think I ever actively pooh-poohed CFS, but like everyone else who encountered it, I underestimated just how bad it was until I met some patients with the condition. It is real and really bad. For whatever reason it is hard to think about and take seriously, but it really is as bad as people say. </preachiness> 6. Long COVID is probably rare in children This matters a lot, because children are (currently) ineligible for the vaccine, and also likely to encounter the virus at school. But children usually have mild cases of COVID and don’t die from it, so it’s tempting to just not worry about them. But if they could get Long COVID, that would make it much less tempting. Preliminary Evidence On Long COVID In Children sounds like a good paper to draw conclusions from. It says 42.6% of children with COVID experience long-term follow-up symptoms, which would be higher than the rate for adults. But it has no control group, and most of the symptoms it finds don’t seem very COVID-related (eg rashes, constipation). The most common symptom (20%) is insomnia, which better studies in adults fail to associate with real Long COVID. The rate of known long COVID symptoms (eg taste and smell problems) is only about 3-4%, and no higher or lower than anything else. Probably these kids are just having problems at the usual rate and attributing them to their recent COVID. Blankenburg et al do the correct thing and ask a thousand children about potential symptoms, then compare the number who say yes vs. no among COVID-seropositive and seronegative subjects. They find no difference between the two groups. Both are reporting a lot of insomnia, etc. They reasonably attribute this to pandemics being a stressful event that it’s natural to lose sleep over. This is really reassuring, but it can’t rule out a somewhat rarer syndrome. The authors say that they might miss symptoms with a prevalence of less than 10%, and one of them gives his own personal guess that it’s 1%. An English team says there’s a Long COVID rate of 4.6% in kids. But there was a 1.7% rate of similar symptoms in the control group of kids who didn’t have COVID, so I think it would be fair to subtract that and end up with 2.9%. And even though the study started with 5000 children, so few of them got COVID, and so few of those got long COVID, that the 2.9% turns out to be about five kids. I don’t really want to update too much based on five kids, especially given the risk of recall bias (ie you might notice / care about your symptoms more if you know you had COVID before getting them). My overall conclusion here is that long COVID is rarer in children than adults, and may not exist at all. The studies tell us it’s probably somewhere less than 5% of kids, but so far we can’t conclude anything stronger than that. 7. Vaccination probably doesn’t change the per-symptomatic-case risk of Long COVID much Here’s a complicated Twitter thread about this. Of vaccinated people who got symptomatic COVID, about a third ended up with Long COVID symptoms, the same rate as in unvaccinated people. Of course, vaccinated people are much less likely to get symptomatic COVID. But even conditional on getting it, they’re still much less likely to go to the hospital, die, etc. It would have been nice if the same was true of getting Long COVID. But it doesn’t look that way. (all this information is from an online poll by a sketchy group of COVID “survivor” activists. But they wrote up their poll in the scientific paper font, as a PDF and everything, so I say we count it anyway) This NEJM study wasn’t exactly designed to look for Long COVID in vaccinated people. But they found it anyway, at a rate of 19% after 6 weeks. This also fits within the (wide) range reported for unvaccinated people. They don’t give a symptom breakdown beyond “prolonged loss of smell, persistent cough, fatigue, weakness, dyspnea, or myalgia”, which sounds like the usual set. These studies are pretty weak, and you could argue that given that vaccines decrease the average severity of COVID infection, and infection severity is linked to Long COVID risk, we should have a strong prior on vaccines decreasing Long COVID risk. And just before publishing this, someone sent me this study, which very preliminarily finds vaccines might decrease Long COVID risk by a factor of 2. I think a factor of 2-3 is believable; one of 10 or 20, less so. Weirdly, there are some claims that vaccines can help relieve symptoms of existing long COVID. Sounds kind of like sympathetic magic to me, but the researcher quoted in the linked article said it might “improve symptoms by eliminating any virus or viral remnants left in the body” or by “rebalancing the immune system”. So yeah, sympathetic magic. 8. Your risk of a terrible long COVID outcome conditional on COVID is probably between a few tenths of a percent and a few percent. My original calculation went like this: About 25% of people who get COVID report long COVID symptoms. About half of those go away after a few months, so 12.5% get persistent symptoms. Suppose that half of those cases (totally made-up number) are very mild and not worth worrying about. Then 6.25% of people who get COVID would have serious long-lasting Long COVID symptoms. After doing that calculation, I read this essay by Matt Bell, who tries to figure out the same thing. He is much more optimistic. He agrees that about half of long COVID cases go away after a few months, but adds another 50% decrease from “few months” to “lifelong”, kind of on priors, admitting there’s not too much positive evidence for this. Then he adds another factor-of-two decrease from vaccination, based on very preliminary studies from the UK. He estimates that someone with my demographics (vaccinated man in his 30s) has a 2% risk of Long COVID conditional on getting COVID at all. Then he divides by five for the true worst case scenario, based on studies showing that a fifth of people with Long COVID report that it affects their daily activities “a lot”. So by his final number, I have an 0.4% chance of getting really terrible long COVID, conditional on getting COVID at all. My friend AcesoUnderGlass also did a writeup of this, published after I did my first-draft calculation, which seems to be thinking of this very differently, based entirely on hospitalization rates (which of course are very low in vaccinated people our age). She accordingly concludes that risk is very low. I don’t really understand her reasoning here, but I trust her a lot and am working on trying to converge with her on this. What’s my yearly risk of getting COVID if I try to live a normal life? This site says only 0.1% of vaccinated Californians have gotten COVID after their vaccination. But vaccination was pretty new when that survey was done, so we might want to take this as a per one-to-two-months estimate. That would mean a risk of 0.5 - 1 percent per year. But not all these people are living normal lives, so my risk might be higher. MicroCOVID gives me a good sense of how careful I’d have to be to stay within a risk budget of 1% COVID risk per year. When I play around with it, I think I am about 5x - 10x less careful than that, which would mean a risk of about 5%/year. This tracker suggests my area has recently had about 1 new case per thousand people per week, which would imply 5% per year. But most of those people are probably unvaccinated, so my risk would be significantly lower than that. I’m going to round all of this off to about 1% - 10% per year of getting a breakthrough COVID case (though obviously this could change if the national picture got better or worse). Combined with the 0.4% to 6.25% risk of getting terrible long COVID conditional on getting COVID, that’s between a 1/150 - 1/25,000 chance of terrible long COVID per year. How does this compare to other risks? My ordinary risk of death per year, just from being a man in his 30s, is about 1/700 (though this includes drug abusers and stunt pilots, so my real risk might be lower, let’s say 1/1000). Here are some other risks, courtesy of the BMJ: In this context, I find the 1/150 risk pretty scary and the 1/25,000 risk not scary at all, so, darn, I guess there’s not yet enough data to have a strong sense of how concerned I should be. 9. This is hard to compare to other postviral syndromes Going into this, I wondered if we might be able to ignore Long COVID. The argument would go like this: all viral diseases have a risk of postviral syndromes. Colds, flus, mono, lots of stuff that’s going around all the time. Lots of people get those postviral syndromes, and either recover or don’t, but either way we don’t make a big deal out of it. Since COVID’s considered “newsworthy” in a way flu isn’t, we obsess over its postviral syndrome even though it’s no worse than anything else’s. This wouldn’t make Long COVID any less bad, and maybe we would be wrong to not panic more about colds and the flu, but it would at least give us some context and make things feel less scary. Unfortunately, I can’t find anything supporting or opposing this picture. The only relevant study is a meta-analysis by Poole-Wright et al, who (contra nominative determinism) don’t pool the studies by condition, which makes it hard to draw conclusions. I think all of their examples of postviral syndrome after flu are from severe hospitalized cases, so any comparison with COVID would be unfair. Although there do seem to be scattered reports of post-flu problems, they’ve never been formally studied or quantified. Mononucleosis is an infectious disease caused by the Epstein-Barr virus, affecting about 1/2000 people per year in developed countries. It has a famously nasty postviral syndrome, which this paper describes as “almost one-half of the group had substantial ongoing symptoms 2 months after onset and… ∼10% had disabling symptoms marked by fatigue lasting ≥ 6 months”. Flu is as common as COVID, but nobody really talks about it having a significant postviral syndrome so probably it’s not that bad. Mono has a worse postviral syndrome than COVID, but it’s rare enough that it doesn’t cause massive society-wide effects. COVID is right in the middle: more common than mono, and (probably) worse postviral syndrome than flu. I think it’s fair to say that we may not have encountered a condition with this exact combination of risk factors and can’t dismiss it as similar to conditions we currently ignore. One potential analogue might be the Spanish Flu of 1918. It was an equally widespread pandemic, and seemed to have some kind of postviral syndrome. From TIME: In what is now Tanzania, to the north, post-viral syndrome has been blamed for triggering the worst famine in a century—the so-called “famine of corms”—after debilitating lethargy prevented flu survivors from planting when the rains came at the end of 1918. “Agriculture suffered particular disruption because, not only did the epidemic coincide with the planting season in some parts of the country, but in others it came at the time for harvesting and sheep-shearing.” Kathleen Brant, who lived on a farm in Taranaki, New Zealand, told Rice, the historian, about the “legion” problems farmers in her district encountered following the pandemic, even though all patients survived: “The effects of loss of production were felt for a long time.” The 1918 flu seemed to have lots of psychiatric effects: “Norwegian demographer Svenn-Erik Mamelund provided such evidence when he combed the records of psychiatric institutions in his country to show that the average number of admissions showed a seven-fold increase in each of the six years following the pandemic, compared to earlier, non-pandemic years.” Coronavirus doesn’t - the excellent Amin-Chowdhury study above finds nothing. Still, this is the scale of thing I’m worried about. The worst case scenario here is really really bad. If a few percent of COVID patients get long-term unremitting genuine CFS/ME, that has the potential to overwhelm government welfare budgets and long-term depress the economy. I think there’s a 90% chance the real situation isn’t that bad, but it’s scary that we can’t entirely rule it out. Aside from the somewhat different 1918 case, I don’t think we have any historical experience of dealing with postviral syndromes at this scale. The medium case scenario is something more like “a few percent of infected people get moderate fatigue, which doesn’t really prevent them from working, and goes away after a few years”. I don’t know whether the level of media attention paid to this would converge on “boring and nobody notices” or “giant disaster”, and I think it would be compatible with either. 10. Conclusions 1. Long COVID is many different issues without a common mechanism. 2. Some of these are straightforward and not surprising, eg lung scarring and post-ICU syndrome from severe infection, and would happen in any disease of this severity. Others seem to be more like the poorly-understood postviral syndromes associated with several other diseases. While some symptoms may be psychosomatic, most are probably organic. 3 The three major categories of symptoms are straightforward cardiovascular-pulmonary issues, straightforward smell and taste issues, and more mysterious neurological issues. 4 Although these get better with time in some people, in a significant number (maybe ~50% of people who had them at six weeks) they persist for as long as anyone has been able to measure them (a few months in the case of COVID, a year or two in the case of comparable syndromes). 5. Post-COVID fatigue is particularly concerning. This would be very bad if we analogized it to CFS/ME, and still pretty bad if we analogized it to other known postviral syndromes. There is no proof that this always gets better over the long term, although no study has looked at them for more than a few years. Facing postviral fatigue on this scale is a new problem. 6 . Children probably get Long COVID less than adults, probably at a rate of less than 5% of symptomatic cases. But we don’t know how much less, and we can’t rule out that some children get pretty severe symptoms. 7. Although vaccination decreases the risk of symptomatic COVID, it probably doesn’t decrease the risk of Long COVID per symptomatic COVID case by very much, though it might decrease it by a factor of 2-3. 8. Your chance of really bad debilitating lifelong Long COVID, conditional on getting COVID, is probably somewhere between a few tenths of a percent, and a few percent. Your chance per year of getting it by living a normal lifestyle depends on what you consider a normal lifestyle and on the future course of the pandemic. For me, under reasonable assumptions, it’s probably well below one percent. EDIT: Here are some other people who tried to do this same analysis. I learned about all of these after I wrote the first draft of this, so you can consider the basic thought process here to be independent of them - but I edited some things to account for what I learned from them before writing the final version. AcesoUnderGlass: Long COVID Is Not Necessarily Your Biggest Problem
Inline links: source, 63 patients over three years, https://substackcdn.com/image/fetch/$s_!TUEK!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2Fec23b8cd-a86e-4bb2-906b-b406b3000248_896x569.png, ME-Pedia, https://substackcdn.com/image/fetch/$s_!ldiD!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2Fa4352e07-08e4-4e08-8a9e-6d2752dcc491_1208x565.png, Lizardman, this Australian study, these people, The Dubious Origins Of Long COVID, weird x-rays, Sniffin Sticks test, somewhere between 60 and 80%, somewhere between 2x and 4x more likely, for example, the creepy shadow war between mother and fetus, Bryan Caplan, wrote, added, Preliminary Evidence On Long COVID In Children, Blankenburg et al, one of them, English team says, Here’s, the scientific paper font, This NEJM study, infection severity is linked to Long COVID risk, this study, vaccines can help relieve symptoms of existing long COVID, this essay, a writeup of this, This site says, MicroCOVID, This tracker, the BMJ, https://substackcdn.com/image/fetch/$s_!yL40!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F1eea7cfa-df08-4c67-acf2-da24ce860ae3_713x373.png, a meta-analysis by Poole-Wright et al, scattered reports, this paper, postviral syndrome
In this context, I find the 1/150 risk pretty scary and the 1/25,000 risk not scary at all, so, darn, I guess there’s not yet enough data to have a strong sense of how concerned I should be. 9. This is hard to compare to other postviral syndromes Going into this, I wondered if we might be able to ignore Long COVID. The argument would go like this: all viral diseases have a risk of postviral syndromes. Colds, flus, mono, lots of stuff that’s going around all the time. Lots of people get those postviral syndromes, and either recover or don’t, but either way we don’t make a big deal out of it. Since COVID’s considered “newsworthy” in a way flu isn’t, we obsess over its postviral syndrome even though it’s no worse than anything else’s. This wouldn’t make Long COVID any less bad, and maybe we would be wrong to not panic more about colds and the flu, but it would at least give us some context and make things feel less scary. Unfortunately, I can’t find anything supporting or opposing this picture. The only relevant study is a meta-analysis by Poole-Wright et al, who (contra nominative determinism) don’t pool the studies by condition, which makes it hard to draw conclusions. I think all of their examples of postviral syndrome after flu are from severe hospitalized cases, so any comparison with COVID would be unfair. Although there do seem to be scattered reports of post-flu problems, they’ve never been formally studied or quantified. Mononucleosis is an infectious disease caused by the Epstein-Barr virus, affecting about 1/2000 people per year in developed countries. It has a famously nasty postviral syndrome, which this paper describes as “almost one-half of the group had substantial ongoing symptoms 2 months after onset and… ∼10% had disabling symptoms marked by fatigue lasting ≥ 6 months”. Flu is as common as COVID, but nobody really talks about it having a significant postviral syndrome so probably it’s not that bad. Mono has a worse postviral syndrome than COVID, but it’s rare enough that it doesn’t cause massive society-wide effects. COVID is right in the middle: more common than mono, and (probably) worse postviral syndrome than flu. I think it’s fair to say that we may not have encountered a condition with this exact combination of risk factors and can’t dismiss it as similar to conditions we currently ignore. One potential analogue might be the Spanish Flu of 1918. It was an equally widespread pandemic, and seemed to have some kind of postviral syndrome. From TIME: In what is now Tanzania, to the north, post-viral syndrome has been blamed for triggering the worst famine in a century—the so-called “famine of corms”—after debilitating lethargy prevented flu survivors from planting when the rains came at the end of 1918. “Agriculture suffered particular disruption because, not only did the epidemic coincide with the planting season in some parts of the country, but in others it came at the time for harvesting and sheep-shearing.” Kathleen Brant, who lived on a farm in Taranaki, New Zealand, told Rice, the historian, about the “legion” problems farmers in her district encountered following the pandemic, even though all patients survived: “The effects of loss of production were felt for a long time.” The 1918 flu seemed to have lots of psychiatric effects: “Norwegian demographer Svenn-Erik Mamelund provided such evidence when he combed the records of psychiatric institutions in his country to show that the average number of admissions showed a seven-fold increase in each of the six years following the pandemic, compared to earlier, non-pandemic years.” Coronavirus doesn’t - the excellent Amin-Chowdhury study above finds nothing. Still, this is the scale of thing I’m worried about. The worst case scenario here is really really bad. If a few percent of COVID patients get long-term unremitting genuine CFS/ME, that has the potential to overwhelm government welfare budgets and long-term depress the economy. I think there’s a 90% chance the real situation isn’t that bad, but it’s scary that we can’t entirely rule it out. Aside from the somewhat different 1918 case, I don’t think we have any historical experience of dealing with postviral syndromes at this scale. The medium case scenario is something more like “a few percent of infected people get moderate fatigue, which doesn’t really prevent them from working, and goes away after a few years”. I don’t know whether the level of media attention paid to this would converge on “boring and nobody notices” or “giant disaster”, and I think it would be compatible with either. 10. Conclusions 1. Long COVID is many different issues without a common mechanism. 2. Some of these are straightforward and not surprising, eg lung scarring and post-ICU syndrome from severe infection, and would happen in any disease of this severity. Others seem to be more like the poorly-understood postviral syndromes associated with several other diseases. While some symptoms may be psychosomatic, most are probably organic. 3 The three major categories of symptoms are straightforward cardiovascular-pulmonary issues, straightforward smell and taste issues, and more mysterious neurological issues. 4 Although these get better with time in some people, in a significant number (maybe ~50% of people who had them at six weeks) they persist for as long as anyone has been able to measure them (a few months in the case of COVID, a year or two in the case of comparable syndromes). 5. Post-COVID fatigue is particularly concerning. This would be very bad if we analogized it to CFS/ME, and still pretty bad if we analogized it to other known postviral syndromes. There is no proof that this always gets better over the long term, although no study has looked at them for more than a few years. Facing postviral fatigue on this scale is a new problem. 6 . Children probably get Long COVID less than adults, probably at a rate of less than 5% of symptomatic cases. But we don’t know how much less, and we can’t rule out that some children get pretty severe symptoms. 7. Although vaccination decreases the risk of symptomatic COVID, it probably doesn’t decrease the risk of Long COVID per symptomatic COVID case by very much, though it might decrease it by a factor of 2-3. 8. Your chance of really bad debilitating lifelong Long COVID, conditional on getting COVID, is probably somewhere between a few tenths of a percent, and a few percent. Your chance per year of getting it by living a normal lifestyle depends on what you consider a normal lifestyle and on the future course of the pandemic. For me, under reasonable assumptions, it’s probably well below one percent. EDIT: Here are some other people who tried to do this same analysis. I learned about all of these after I wrote the first draft of this, so you can consider the basic thought process here to be independent of them - but I edited some things to account for what I learned from them before writing the final version. AcesoUnderGlass: Long COVID Is Not Necessarily Your Biggest Problem
Inline links: a meta-analysis by Poole-Wright et al, scattered reports, this paper, postviral syndrome, Long COVID Is Not Necessarily Your Biggest Problem
potato1 mentions across 1 issues

potato is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between April 16, 2021 and April 16, 2021. The archive places it in contexts such as "why did they depend on a single monoculture crop (the potato)". It most often appears alongside "The Rent Is Too Damn High!", 16th amendment, 1886.

Reference entry
potato
Mention count
1
Issue count
1
First seen
April 16, 2021
Last seen
April 16, 2021
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Your Book Review: Progress And Poverty
April 16, 2021 · Original source
By making possible the division & specialization of labor (you dig bait, I'll catch fish) Capital is a force multiplier that supercharges the productive power of labor. It doesn't supply labor with raw materials (nature does), nor does it provide for the maintenance of workers (who eat bread by the sweat of their own brow). George says this is why capital isn't a limit on industry. ...okay, George grants that capital may limit the form of industry. You can't plow without a plow or milk without a cow. George also grants that the lack of specialized tools can greatly limit productivity because you don't get the benefit of the force-multiplying effect of capital. Um... aren't you contradicting yourself here, Mr. George? You spent all this time hammering home your doctrine of wages to prove that capital doesn't limit industry, but you just said its absence can limit both the form and the productivity of labor! Time to unpack what we mean by "limit" and be super clear about it from now on: But to say that capital may limit the form of industry or the productiveness of industry is a very different thing from saying that capital limits industry. Okay, what do you mean? For the dictum of the current political economy that "capital limits industry," means not that capital limits the form of labor or the productiveness of labor, but that it limits the exertion of labor. Okay, I think I see what he's saying. The existing school of thought says that because capital provides labor with both materials and maintenance, therefore if capital dries up, labor productivity must go down because workers will have nothing to work on, and nothing to eat or wear. Labor is thus "limited" by capital, for without it is literally and metaphorically starved for capital. But George says no – the only way capital actually "limits" productivity in real life is in the degrees by which it force-multiplies labor's productivity and unlocks certain forms of labor in the tech tree. The kind of "limit" George objects to is the idea that you need capital just to get any work done at all, or that without capital to sustain it, labor will shrivel up. Instead, capital is rocket fuel that labor supplies to itself by investing a portion of its wages. And yet, with all the awesome slots we've unlocked on the tech tree, and barrels and barrels of rocket fuel to fire up eager laborers, we still find our economy sinking into mysterious depressions. Something is gumming up the works, but it's not a simple scarcity of capital: the real limitation is not the want of capital, but the want of its proper distribution Or as G.K. Chesterton said, "Too much capitalism does not mean too many capitalists, but too few capitalists." This might seem like a pedantic distinction – misallocated capital could be said to be "scarce" capital – but they're not the same thing at all. As Francis Bacon said in 1625: Riches were like [Manure]: When it lay, upon an heape, it gave but a stench, and ill odour; but when it was spread upon the ground, then it was cause of much fruit. Because the prevailing theories of George's time are based on incorrect ideas about the relation between wages and capital, "all remedies, whether proposed by professors of political economy or workingmen, which look to the alleviation of poverty either by the increase of capital or the restriction of the number of laborers or the efficiency of their work, must be condemned." In short, more investment, more protectionism, and more efficiency programs can't, won't, and haven't fixed poverty and industrial depressions because they all proceed from false premises. Having finally beaten the nexus of wages, capital, and labor into a bloody pulp, George turns his eyes towards another leading theory for why everything is terrible: the specter of overpopulation. II. Population and Subsistence The entire second book might as well be titled "Why Malthus is Dumb and Wrong and Bad." It's dedicated to dunking on Malthusianism, a philosophy that ascribes economic crises to the exponential growth of the human population, which must necessarily end in catastrophe. according to Malthusian theory, poverty appears as increase in population necessitates the more minute division of subsistence. George attacks Malthusian ideas not just because they're wrong, but because they make it easier to accept the prevailing theory of wages (as more capital is allocated, laborers will keep popping up like weeds to gobble it up, so wages must eternally stagnate). George draws a straight line between these faulty ideas and holocausts and genocides – specifically citing how colonial oppression in China, India, and Ireland were explicitly justified on Malthusian grounds. One million people died in the English-engineered Irish potato famine alone, and when you add in those who fled the entire population declined by 25% percent. And this isn't a tenuous link either – George directly connects the completely avoidable famine to his favorite bugbear, private landownership and extortionate rent. Given that Malthusianism is now widely discredited I'm just going to skip this chapter, but if you want to hear George in all his righteous fury, check out Appendix A (there's a link that returns here at the end): Appendix A: George Dunks on Malthusianism III. The Laws of Distribution When society produces wealth, who gets different shares of it, and why? Let's start by beating some words to death. By George, we're told that there are three factors in production: Land, Labor, and Capital. For each of these terms there must be a "law of distribution" that explains how each gets compensated for its part in production. The reward you get from production by owning Land is called Rent. The reward you get from production by supplying Labor is called Wages. The reward you get from production by supplying Capital is called ... um, what? We're looking for a term that clearly expresses the return to capital alone and nothing else. The closest thing we have is Interest, and that's probably good enough. George gives the common definition of interest as "the return for the use of capital, exclusive of any labor in its use or management, and exclusive of any risk, except such as may be involved in the security." This is pretty close to what we want – something that expresses the sole return to capital without mixing in anything else. But ... what about Profits? Profits is "almost synonymous" with revenue, assuming you have some left after you deduct expenses. It means a gain in money or wealth, but the trouble is this gain is a mix of rent, wages, and "compensations for the risk peculiar to the various uses of capital." What we want is a term that means the return to capital alone, totally separate from the return to laborers and landowners. To talk about the distribution of wealth into rent, wages, and profits is like talking of the division of mankind into men, women, and human beings. George spends a few pages talking about how everyone from Adam Smith on down got confused about this (spoiler: it's tied up with thinking wages are drawn from capital), before presenting his model for how it all works. If you want to see him knock that stuff down, see Appendix B (there's a link that returns here at the end): Appendix B: George dunks on the Conventional Laws of Distribution Here's George's model for how it all works: Land is"all natural opportunities or forces" and its return is rent Labor is "all human exertion" and its return is wages Capital is"all wealth used to produce more wealth" and its return is interest George says the false assumption at the root of the old theories is in thinking of "capital as the prime factor in production, land as its instrument, and labor as its agent or tool." George makes the following assertions: "Labor can be exerted only upon land"
Inline links: Francis Bacon said in 1625, Malthusianism, English-engineered Irish potato famine, Appendix A: George Dunks on Malthusianism, Appendix B: George dunks on the Conventional Laws of Distribution
Towards a Truly Free Market by John Medaille Appendices These are optional elaborations on sections I glossed over because the Book Review Is Too Damn Long. Appendix A: George Dunks on Malthusianism Malthusianism in George's time was wildly popular, and often invoked by the ascendant proponents of Social Darwinism who took Charles Darwin's theory of "survival of the fittest" and recast it as a moral justification for the Just World Hypothesis. Essentially, those that are doing well do so because they are more "fit", and those that are less "fit" tend to perish, and furthermore, this brutal process will actively "improve" the human race. This philosophy was the energizing intellectual force behind both the Eugenics movement and Nazi Germany. George clearly hates everything about this philosophy but attempts to steel-man it anyways: The Malthusian doctrine, as at present held, may be thus stated in its strongest and least objectionable form: That population, constantly tending to increase, must, when unrestrained, ultimately press against the limits of subsistence, not as against a fixed, but as against an elastic barrier, which makes the procurement of subsistence progressively more and more difficult. And thus, wherever reproduction has had time to assert its power, and is unchecked by prudence, there must exist that degree of want which will keep population within the bounds of subsistence. The weak form of Malthusianism is "people are as dumb as deer and will breed endlessly until there's not enough food and everyone starves to death." The strong form of Malthusianism is, "of course people aren't mindless deer charging into a brick wall, but there is a firm upper limit that can only give so much before nature will cull the herd without mercy." And by George, we can't just dismiss the strong form out of hand: "what seems clearer than that there are too many people?" However, George is suspicious of how easily the Malthusian theory justifies contemporary economic assumptions and assuages the moral sensibilities of the establishment: The great cause of the triumph of this theory is that, instead of menacing any vested right or antagonizing any powerful interest, it is eminently soothing and reassuring to the classes who, wielding the power of wealth, largely dominate thought... It furnishes a philosophy by which Dives as he feasts can shut out the image of Lazarus who faints with hunger at his door; He points out how it lets self-styled "Good Christian Men" reframe their own greed and indifference as just plain good sense: In this view, he who in the midst of want has accumulated wealth, has but fenced in a little oasis from the driving sand which else would have overwhelmed it. He has gained for himself, but has hurt nobody. And even if the rich were literally to obey the injunctions of Christ and divide their wealth among the poor, nothing would be gained. (Aside: I've heard this exact defense offered by many of my fellow Christians) Okay, George makes a strong moral case. But a moral case isn't enough, and I think this is where many activists of all political stripes go wrong. If you attack the premises of an idea as "dangerous" because it could lead to bad consequences, you're still stuck with a real problem if the premises that animate that "dangerous" idea turn out to be actually true. If they're true we're stuck with them, and unless your competing policy admits to the same grim facts, your opponent will just dismiss your entire argument and more importantly, so will their audience. But if the premises aren't true, then the dangerous and scary policy prescription – say, "let the Irish starve to death" – is both evil and unnecessary. History has shown that many officials will shrug their shoulders at "evil" policies so long as they believe them to be "necessary." Cool, we've established that Malthusianism is bad. Now let's establish that it's wrong. A Brief Interlude from the Future From where we're sitting in 2021, we don't even need George to refute Malthusianism, history has done that for us. Instead of increasing at an exponential rate, fertility rates are crashing all over the world. Not in one country, but in virtually every country, and in many the birth rate is already below replacement. Fertility rates have been crashing so hard that some are calling it a "Global Fertility Crisis." The absolute size of the human population is still growing, but this is just due to inertia; the human population will peak somewhere between 9 and 10 billion in the 2060's, and then decline from there. The two main things Malthus got wrong were failing to anticipate 1) advances in food production technology like the Green Revolution, and 2) that humans can control their own fertility rates. George's strongest arguments against Malthusianism strike directly at the provably false claims of its 19th century proponents and provide some extremely salient applications of George's philosophy. George takes up the cause of India, China, and Ireland, which were often cited as examples of "overpopulated" countries where many have starved and been forced to emigrate. Per the Malthusians, this is the fault of too many of these poor, ignorant, and deficient people crammed together in too small a space. By George, it can't be the fault of population density – in his time, Germany, Belgium, England, Netherlands and Italy all have higher population densities than India, China, and Ireland, and could therefore support higher populations with the right conditions. And there's certainly nothing wrong with the people themselves: This arises from no innate deficiency in the people, for the Hindoo, as comparative philology has shown, is of our own blood, and China possessed a high degree of civilization and the rudiments of the most important modern inventions when our ancestors were wandering savages. Instead: It arises from the form which the social organization has in both countries taken, which has shackled productive power and robbed industry of its reward. India is poor not because it has too many Indians, but because it is oppressed by too many Englishmen: The millions of India have bowed their necks beneath the yokes of many conquerors, but worse of all is the steady grinding weight of English domination... India now is like a great estate owned by an absentee and alien landlord George gives us lots of details about the plight of India, China, and Ireland, but for the sake of brevity I'm just going to present the heartbreaking case of the Great Irish Potato Famine and let it stand in for all three. To sum up, from 1845 to 1852 there was a period of mass starvation and disease in Ireland. About one million people died, and another million fled the country. The entire population dropped by about 25%: The extreme poverty of the peasantry and the low rate of wages there prevailing, the Irish famine, and Irish emigration, are constantly referred to as a demonstration of the Malthusian theory worked out under the eyes of the civilized world. Many prominent intellectuals of the day looked at the crisis, shook their heads, and said – what do you expect when those ignorant Irish Catholics breed like rabbits and strain Ireland's carrying capacity to its limit? It's just natural selection at work! George will have none of it: The laborer was just as effectually stripped by as merciless a horde of landlords, among whom the soil had been divided as their absolute possession, regardless of any rights of those who lived upon it. Okay, they had to pay some rent, so what? Didn't they bring their suffering on themselves? Why, the intellectuals ask, didn't the Irish work harder, why did they not improve their local economy and agricultural base? And most importantly, why did they depend on a single monoculture crop (the potato) if a single blight could knock out their entire food supply? By George, because The Rent Was Too Damn High! tenants... even if the rack-rents which they were forced to pay had permitted them, did not dare to make improvements which would have been but the signal for an increase of rent. Labor was thus applied in the most inefficient and wasteful manner. (emphases mine) The Irish were really trapped. Working harder to improve the farmland to increase its yield could actually leave them worse off. Any increase in their land's productivity goes to the landlord in the form of increased rents. But even this structural impoverishment of the land wasn't sufficient to cause the famine. Ireland still produced enough food to feed its people: For when her population was at its highest, Ireland was a food-exporting country. Even during the famine, grain and meat and butter and cheese were carted for exportation along roads lined with the starving and past trenches in which the dead were piled. People were literally starving and dying, but because of the structure of land ownership they couldn't even pay their rent, let alone purchase the food grown from their own lands and raised with their own hands. Since the local population couldn't afford it, the (English) landlords sold it abroad to the highest bidder. It went not as an exchange, but as a tribute – to pay the rent of absentee landlords; a levy wrung from producers by those who in no wise contributed to production... they lived on the potato, because rack-rents stripped everything else from them. The Rent Is Too Damn High, and it's not because the designated underclass of the day have too many babies or are too uneducated, too ignorant, too religious, too lazy, or too foreign. George gets really mad about this, and calls out John Stuart Mill and Henry Thomas Buckle by name for lending credence to the Malthusian explanation of Ireland's suffering. I know of nothing better calculated to make the blood boil than the cold accounts of the grasping, grinding tyranny to which the Irish people have been subjected, and to which, and not to any inability of the land to support its population, Irish pauperism and Irish famine are to be attributed; and were it not for the enervating effect which the history of the world proves to be everywhere the result of abject poverty, it would be difficult to resist something like a feeling of contempt for a race who, stung by such wrongs, have only occasionally murdered a landlord! Appendix B: George dunks on the Conventional Laws of Distribution Conventional Law 1: Wages aredetermined by the ratio between capital devoted to the payment & subsistence of labor, divided up by the number of laborers. Conventional Law 2: Rent is determined by something called the "margin of production," AKA the "margin of cultivation." What's that? Let L be some land. Let W be the worst land available. Let A = the produce L makes. Let B = the produce you get applying the same amount of labor and capital to W. The Rent of L is given by A - B. The margin of production/cultivation is the difference between how much you can produce from a particular piece of land compared to the least productive alternative. This is the only conventional law of distribution that George accepts as correct. Conventional Law 3: Interest is the ratio between capital demanded by borrowers and supplied by lenders, falling as wages rise and vice versa. To quote Mill, interest is determined "by the cost of labor to the capitalist." The problem with these three laws is if Land, Labor, and Capital are the only three factors of production, and each gets its own return, than the three returns should balance. In other words: Return to Production = Rent + Wages + Interest If your three returns sum to more or less than 100% of the return to production, something's off, and George says the old laws don't add up – the only one of these he accepts is the law of rent. What's wrong with the other two? First we've got to stop using "profits" to mean a return to capital. If we look into a profit stream, we see more than one kind of thing. Conventional economists list the following: Wages of "superintendence"
Inline links: Towards a Truly Free Market, Social Darwinism, Just World Hypothesis, Eugenics, so long as they believe them to be "necessary.", fertility rates are crashing all over the world, Global Fertility Crisis, human population will peak, Green Revolution, Great Irish Potato Famine
potlatch1 mentions across 1 issues

potlatch is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between June 10, 2022 and June 10, 2022. The archive places it in contexts such as "hosting the great banquets known as potlatch". It most often appears alongside 50,000 BC, Africa, Altamira.

Reference entry
potlatch
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1
Issue count
1
First seen
June 10, 2022
Last seen
June 10, 2022
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Your Book Review: The Dawn Of Everything
June 10, 2022 · Original source
it was winter—not summer—that was the time when society crystallized into its most hierarchical forms, and spectacularly so. Plank-built palaces sprang to life along the coastline of British Columbia, with hereditary nobles holding court over compatriots classified as commoners and slaves, and hosting the great banquets known as potlatch. Yet, these aristocratic courts broke apart for the summer work of the fishing season, reverting to smaller clan formations—still ranked, but with entirely different and much less formal structures. In this case, people actually adopted different names in summer and winter—literally becoming someone else, depending on the time of year.
had to ‘keep up’ his name through generous feasting, potlatching, and general open-handedness.
Pour le Mérite1 mentions across 1 issues

Pour le Mérite is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between July 28, 2023 and July 28, 2023. The archive places it in contexts such as "He had the Pour le Mérite , the equivalent of the Medal of Honor in the Kaiserreich". It most often appears alongside 1923 Hyperinflation, Adolf Hitler, All hope abandon, ye who enter here.

Reference entry
Pour le Mérite
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1
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1
First seen
July 28, 2023
Last seen
July 28, 2023
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Your Book Review: On the Marble Cliffs
July 28, 2023 · Original source
To expose what in my opinion is the actual point of this book, but which (no doubt due to its many other attractions) all reviews of it I have read have missed entirely. The German Catastrophe The obvious frame for this book is what has been fittingly termed the German Catastrophe: the fate of Germany in the late 19th and early 20th century, as viewed from the perspective of German nationalists who were not Nazis — the perspective of people like Ernst Jünger. Germany had entered modernity without democracy. The Kaiserreich (German Empire) had united the many small German states, aggressively worked to catch up with industrialization, built a state to rival France and Great Britain, and remained authoritarian throughout. Commoners had negligible political influence. They did get social insurance, but not through their own political power but granted top-down, as an appeasement to undermine socialist movements. Civil marriage, secularized state education, prospering state universities and a long series of modernizing laws kept increasing state power. And that meant executive power. There were parties, a parliament and a newly homogenized judiciary, but they had little power to check the executive. And this entire development was accompanied by a lot of theorizing about this new German nation. Much of this theorizing ended up justifying authoritarianism, by making quickly-spreading myths about how obedience to authority, respect for aristocracy and love for tradition were uniquely German traits that set Germans apart from the French and the Jews and other dubious foreigners. Such myths, and opposition to them, colored the German population’s hard work to get accustomed to industrialization, urbanization, education, rapid population growth, militarization, national media and various culture wars. This had seemed to work okay-ish while Bismarck, wielding both enormous ruthlessness and enormous political acumen, had navigated Germany through the trials and tribulations of the late 19th century, largely at the expense of France. But in 1890, Emperor Wilhelm II had taken over authority with less ruthlessness and much less political acumen. While his populace remained nearly unable to influence politics, Wilhelm II made critical political mistakes, especially in dealing with other European powers. These mistakes culminated in the first World War. You know how that one went. Germany’s defeat led into Germany’s first real democracy. Everyone was very obviously new to this. The right attacked the new state, falsely claiming it had needlessly capitulated. The left also attacked the new state, because it wasn’t Soviet-Union-like enough. There was a lot of political violence. The massive damage incurred in the war, and the restrictions and reparations Germany had accepted in the peace settlement, put massive strains on an already fragile political system. Elections were tumultuous and frequent. Hyperinflation caused a huge crisis in 1923, and the Great Depression of 1929 was another huge disaster for Germany. Overall, the abolition of authoritarianism was widely felt to be a mistake. This seeming mistake was fixed when Hitler stepped in. And you know how that one went. The author in his time One remarkable witness to this entire catastrophe was Ernst Jünger. In 1938, when he picked up the pen to write Auf den Marmor-Klippen (On the Marble Cliffs), he was 43 years old and a complicated man in a complicated situation. He was first and foremost a highly renowned soldier. He had the Pour le Mérite, the equivalent of the Medal of Honor in the Kaiserreich, which would entitle him to a decent stipend if the Kaiserreich hadn't been gone for twenty years. He was clearly brilliant, especially as a writer, very well connected and exchanged many letters with important men on the political right. He made a living as an author, mostly because his first book, the World War I memoir “Storm of Steel”, was a great success and continually got reprinted. He had followed it up with a string of books, all nonfiction — almost all memoirs, about the war, or both. And he had written a flurry of political articles, mostly in ultraconservative and nationalist magazines. On the Marble Cliffs is his very first fiction novel. Or he claimed it was fiction — but he was fooling nobody. Jünger wrote for an audience that was very familiar with Storm of Steel and, because of the autobiographical nature of all of his preceding work, with him as a person. His books revealed him to be a highly perceptive, highly but coldly intelligent, very erudite, sensation seeking… sociopath. He has masterful eloquence and a keen interest in nature. Even in the trenches of the World War, where he enjoyed “hunting down” enemy soldiers with sniper shots, he seemed more interested in the dealings between the insects that bumbled through this hellscape than in how his fellow soldiers inwardly felt about what was going on. And his protagonist in the Marble Cliffs is both the first-person narrator and almost exactly the same guy! All of the following points are true both for the protagonist of this novel, and the author at the time of writing. He lives with his brother on the edge of a small town in a fairly rural area with an old Christian culture and strong traditional crafts of wine making and fishing, overlooking a large body of water, across which is a mountainous foreign country: Alta Plana in the book, Switzerland in reality.
Pournelle's Iron Law1 mentions across 1 issues

Pournelle's Iron Law is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between April 15, 2025 and April 15, 2025. The archive places it in contexts such as "I have to toss in Pournelle's Iron Law. The purpose of a system - when it is first established - may be dramatically different from the purpose it assumes after a few years". It most often appears alongside Affordable Housing Bureau, Ajb, Alienation of labor.

Reference entry
Pournelle's Iron Law
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1
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1
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April 15, 2025
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April 15, 2025
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Highlights From The Comments On POSIWID
April 15, 2025 · Original source
Homeowners want to preserve or increase the value of their houses. Of these, I think 6 is one of the less important ones - if this were the dominating factor, people would support upzoning, since it usually raises the value of properties in the upzone (if developers can build skyscrapers on your land, then your land value goes up relative to the profitability of skyscrapers). But part of the problem is that people don’t support upzoning. So 6 can’t be the dominating factor. Without POSIWID, people could think about all of these possibilities and come to their own conclusions. POSIWID tries to ban thinking about 1-5 by fiat, insisting that 6 is the only possible explanation and anyone considering the others is naive. I think this makes it a bad heuristic. But there are two more concerning things about how Negating is using POSIWID. First, he’s picking out one particularly salient thing the system does (raise house prices) and claim that’s “the” purpose. He could equally well pick any of the other results - preserve neighborhood character, protect the environment, help Chinese people escape currency controls. Like I said in the original post, in practice POSIWID serves as justification for paranoia - whatever effect you like least, whatever possibility would be most sinister - that’s the one that the system is intentionally aiming for. Second, he’s saying it’s the purpose of “the” system. Which system? I bet whatever government he’s talking about has some organization called the Affordable Housing Bureau, or whatever. And I bet that the Affordable Housing Bureau really does make housing slightly more affordable, relative to the counterfactual where it doesn’t exist. It’s just that lots of other government, market, and social forces conspire to make it much less affordable. If Negating were to claim “The purpose of the Affordable Housing Bureau is to make housing less affordable”, this would be false even if the overall picture (the government is deliberately raising real estate prices) were true. Brad writes: I have to toss in Pournelle's Iron Law. The purpose of a system - when it is first established - may be dramatically different from the purpose it assumes after a few years. Consider: You establish a system to solve a problem. That could be homelessness, or asylum, or drug abuse, or any of a number of other things. This system employs people, who then have an automatic interest - not in solving the problem - but in prolonging it, even in making it worse. After all, without the problem, the organization would not need to exist. And hwold writes: I see it used as "if you have a complex system/bureaucracy to solve X, then the incentives inside it is for X to get worse, and incentives will not have 0 influence on outcomes" For example : https://x.com/Devon_Eriksen_/status/1906042672499864034 I think this sounds profound on first glance, and it’s probably true in some cases. But it’s not nearly true enough to be an Iron Law. Try to think about it in specific Near Mode cases: If you eliminated police, would crime go down, because the police have an incentive to preserve crime? If you eliminated the fire department, would fires go down, because the fire department has an incentive to preserve fire? If you eliminated doctors, would cancer deaths go down, because doctors have an incentive to preserve cancer deaths? If you eliminated the FDA, would dangerous drug side effects go down, because the FDA has an incentive to preserve dangerous drug side effects? If you eliminated the Federal Reserve, would bank runs go down, because the Federal Reserve has an incentive to preserve bank runs? Brad’s original comment mentions homelessness and drug abuse, but I know some drug abuse doctors, and they’re (mostly) good people who do their best in a tough situation. Drug abuse doesn’t continue because drug abuse doctors are secretly ensuring it continues to help their bottom line. Drug abuse continues because fentanyl is really, really addictive. Even good conspiracy theories don’t work like this. Was there a conspiracy among pain pill manufacturers to addict people? Yeah, kinda, although I think the degree to which this caused the opioid crisis is pretty overblown. But the pain pill manufacturers weren’t a system dedicated to preventing addiction. They did their job (reduce pain) fine, then ran an unrelated evil conspiracy on the side! Breb writes: This way of thinking may result from taking a strategy for predicting the motives of individuals, and using it to predict the motives of organisations. "Cui bono?" works when you're considering a single action carried out by a single person at a single moment in time, but it doesn't really work when you're considering the behaviour of hundreds of people who are incentivised to somewhat-but-not-perfectly cooperate over a long period to somewhat-but-not-perfectly implement a goal that was established by someone who somewhat-but-not-perfectly understands that that goal is just an instrument to attain a larger, more complex goal set by somebody else. I’m against this for individuals too! There are a million self-help gurus who try to convince you that that if you procrastinate - let’s say you always do term papers the night before and get terrible grades and it’s threatening your ability to complete college - then it must be because this secretly benefits you in some way. Maybe your overly-strict father wants you to complete college, and you’re deliberately trying to fail as a secret act of rebellion against him hidden even from yourself. Although something like this might sometimes be true, more often a clearer understanding of the circuitry involved (in this case, hyperbolic discounting) saves you from these labyrinths and lets you think about things straightforwardly again. Tom J writes: In the original Stafford Beer sense, the slogan POSIWID means that you can't tell from outside the system whether any given behaviour was *intended* or not. For the purposes of objective analysis, you have to treat your system as a black box that *does* whatever it's observed to do, as opposed to what people *claim* the point of the system is. This may be true in cybernetics. Or it may be an interesting methodological commitment, in the same way that the behaviorists’ “assume there is no such thing as human interiority” was an interesting methodological commitment. But I don’t think it’s common or valuable in normal-life analysis of social systems. When Biden bans NVIDIA from sending advanced chips to China, black box analysis would have to be ambivalent between explanations like: Biden personally hates Jensen Huang and wants his company to suffer
Inline links: writes, writes, https://x.com/Devon_Eriksen_/status/1906042672499864034, writes, hyperbolic discounting, writes
Pournelle’s Iron Law of Bureaucracy1 mentions across 1 issues

Pournelle’s Iron Law of Bureaucracy is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between April 15, 2025 and April 15, 2025. The archive places it in contexts such as "real meaning of POSIWID is: Pournelle’s Iron Law of Bureaucracy". It most often appears alongside Affordable Housing Bureau, Ajb, Alienation of labor.

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Highlights From The Comments On POSIWID
April 15, 2025 · Original source
Pournelle’s Iron Law of Bureaucracy
poverty causes cognitive problems1 mentions across 1 issues

poverty causes cognitive problems is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between December 30, 2021 and December 30, 2021. The archive places it in contexts such as "replicate various “poverty causes cognitive problems” studies". It most often appears alongside ACX Grants, Aella, AI Alignment.

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Links For December
December 30, 2021 · Original source
14: An attempt to replicate various “poverty causes cognitive problems” studies goes…well, about the way replication attempts usually go. I was always suspicious of these, people got too excited about this field for political reasons. Related:
Inline links: attempt to replicate
Powdered sugar donuts1 mentions across 1 issues

Powdered sugar donuts is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between April 23, 2021 and April 23, 2021. The archive places it in contexts such as "evolution drives us towards powdered sugar donuts, which actually decrease our fitness". It most often appears alongside Ben Kuhn, Bhikkhu Bodhi, Buddha.

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Powdered sugar donuts
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April 23, 2021
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Your Book Review: Why Buddhism Is True
April 23, 2021 · Original source
According to Wright, evolution has packed us full of illusions. They range from the relatively harmless falsehood “powdered sugar donuts are good for me” to the sweeping distortion “I have a self." These misperceptions are not only inaccurate; they are dangerous. They cause unhappiness by trapping us on the hedonic treadmill and immorality by (among other things) fanning the flames of tribalism.
At his most exciting - and manic - Wright views meditation as a rebellion against evolution. In his view, evolution uses the feelings of pleasure and pain as carrots and sticks. The actions which increase pleasure tend to increase the likelihood of spreading our genes; the unpleasant ones decrease this likelihood. Now this correlation is far from perfect. For instance, evolution drives us towards powdered sugar donuts, which actually decrease our fitness.
Power1 mentions across 1 issues

Power is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between January 21, 2021 and January 21, 2021. The archive places it in contexts such as "It's bad enough to get kicked in the balls because Power hates you". It most often appears alongside 7500 people signed a petition, Alex Tabarrok, Balaji Srinivasan.

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Power
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Still Alive
January 21, 2021 · Original source
But the other reason I didn't do it was...well, suppose Power comes up to you and says hey, I'm gonna kick you in the balls. And when you protest, they say they don't want to make anyone unsafe, so as long as you can prove that kicking you in the balls will cause long-term irrecoverable damage, they'll hold off. And you say, well, it'll hurt quite a lot. And they say that's subjective, they'll need a doctor's note proving you have a chronic pain condition like hyperalgesia or fibromyalgia. And you say fine, I guess I don't have those, but it might be dangerous. And they ask you if you're some sort of expert who can prove there's a high risk of organ rupture, and you have to admit the risk of organ rupture isn't exactly high. But also, they add, didn't you practice taekwondo in college? Isn't that the kind of sport where you can get kicked in the balls pretty easily? Sounds like you're not really that committed to this not-getting-kicked-in-the-balls thing.
It's bad enough to get kicked in the balls because Power hates you. But it's infuriating to have it happen because Power can't bring itself to care. So sure, deleting my blog wasn't the most, shall we say, rational response to the situation. But iterated games sometimes require a strategy that deviates from apparent first-level rationality, where you let yourself consider lose-lose options in order to influence an opponent's behavior.
Inline links: a strategy that deviates from apparent first-level rationality
With all due respect to these reporters, and with complete admission of my own bias, I reject this entire way of looking at things. If someone wants to report that I'm a 30-something psychiatrist who lives in Oakland, California, that's fine, I've had it in my About page for years. If some reporter wants to investigate and confirm, I have some suggestions for how they could use their time better - isn't there still a war in Yemen? - but I'm not going to complain too loudly. But I don't think whatever claim the public has on me includes a right to know my name if I don't want them to. I don't think the public needs to know the name of the cops who write cop blogs, or the deadnames of trans people, or the dating lives of sexy cyborgs. I'm not even sure the public needs to know the name of Satoshi Nakamoto. If he isn't harming anyone, let him have his anonymity! I would rather we get whatever pathologies come from people being able to invent Bitcoin scot-free, than get whatever pathologies come from anyone being allowed to dox anyone else if they can argue that person is "influential". Most people don't start out trying to be influential. They just have a Tumblr or a LiveJournal or something, and a few people read it, and then a few more people read it, and bam! - they're influential! If influence takes away your protection, then none of us are safe - not the random grad student with a Twitter account making fun of bad science, not the teenager with a sex Tumblr, not the aspiring fashionista with an Instagram. I've read lots of interesting discussion on how much power tech oligarchs should or shouldn't be allowed to have. But this is the first time I've seen someone suggest their powers should include a magic privacy-destroying gaze, where just by looking at someone they can transform them into a different kind of citizen with fewer rights. Is Paul Graham some weird kind of basilisk, such that anyone he stares at too long turns into fair game?
power law1 mentions across 1 issues

power law is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between July 01, 2023 and July 01, 2023. The archive places it in contexts such as "mathematical form called a ‘ power law ’". It most often appears alongside 1960 Valdivia earthquake, AEC, Atomic Energy Commission.

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power law
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Your Book Review: Safe Enough?
July 01, 2023 · Original source
Scientists will get into knock-down drag out fights over whether a given data set fits a mathematical form called a ‘power law’, or match better to a 'log normal distribution', where outliers are large but not as dominant. As a point of reference, events that build up one event after the next are commonly power laws, but physics can be subtle, and it turns out an avalanche of snow isn’t a great fit to a power law, while one of rice grains is. As a practical matter, we should focus on the degree to which the worst case event outstrips the rest of the distribution. Generally speaking Nuclear meltdowns should be expected to (and do) mathematically best fit to dragon kings; once an event exceeds a certain damage threshold, it undergoes a “phase change” to a new and much more significant damage mechanism. In the case of nuclear power, the potential maximum cost shifts from “things capped by the budget of a nuclear plant” to “things capped by the budget of a regional economy”.
Inline links: power law, log normal distribution, best fit to dragon kings
power posing1 mentions across 1 issues

power posing is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between August 30, 2021 and August 30, 2021. The archive places it in contexts such as ""It’s very different from “power posing doesn’t exist”""; "We hear 'identifiable victim effect fails to replicate', and it brings up this whole package of things - power posing, stereotype threat". It most often appears alongside Acceptable Losses, Acceptable Losses: The Debatable Origins of Loss Aversion, Alex Imas.

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power posing
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On Hreha On Behavioral Economics
August 30, 2021 · Original source
Somewhere in this process, they did an experiment where they gave participants a quarter minted in Denver and asked them if they wanted to exchange it for a quarter minted in Philadelphia. 60% of people very reasonably didn’t care, but another 35% had grown attached to their Denver quarter, with only 5% actively seeking the novelty of Philadelphia. Psychology is weird. I understand why some people would summarize this paper as “loss aversion doesn’t exist”. But it’s very different from “power posing doesn’t exist” or “stereotype threat doesn’t exist”, where it was found that the effect people were trying to study just didn’t happen, and all the studies saying it did were because of p-hacking or publication bias or something. People are very often averse to losses. This paper just argues that this isn’t caused by a specific “loss aversion” force. It’s caused by other forces which are not exactly loss aversion. We could compare it to centrifugal force in physics: real, but not fundamental. Also, you can’t use this paper to argue that “behavioral economics is dead”. At best, the paper proves that loss aversion is better explained by other behavioral economic concepts. But you can’t get rid of behavioral econ entirely! The stuff you have to explain is still there! It’s just a question of which parts of behavioral econ you use to explain it. Complicating this even further is Mrkva et al, Loss Aversion Has Moderators, But Reports Of Its Death Are Greatly Exaggerated (h/t Alex Imas, who has a great Twitter thread about this). This is an even newer paper, 2019, which argues that Gal and Rucker are wrong, and loss aversion does have an independent existence as a real force. There are many things to like about this paper. Previous criticisms of loss aversion argue that most experiments are performed on undergrads, who are so poor that even small amounts of money might have unusual emotional meaning. Mrkva collects a sample of thousands of millionaires (!) and demonstrates that they show loss aversion for sums of money as small as $20. On the other hand, I’m not sure they’re quite as careful as G&R at ruling out every other possible bias (although I don’t have a great understanding of where the borders between biases are and I can’t say this for sure). The main point I want to make is that all the scientists in this debate seem smart, thoughtful, and impressive. This isn’t like social priming experiments where one person says a crazy thing, nobody ever replicates it at scale, and as soon as someone tries the whole thing collapses. These have been replicated hundreds of times, with the remaining arguments being complicated semantic and philosophical ones about how to distinguish one theory from a very slightly different theory. If that takes replicating your result on a sample of thousands of millionaires, people will gather a sample of thousands of millionaires and get busy on the replication. Just overall really impressive work. I don’t feel qualified to take a side in the G&R vs. Mkrva debate, but both teams make me really happy that there are smart and careful people considering these questions. And this is just a drop in the bucket. Alex Imas also links Replicating patterns of prospect theory for decision under risk, which says: Though substantial evidence supports prospect theory, many presumed canonical theories have drawn scrutiny for recent replication failures. In response, we directly test the original methods in a multinational study (n = 4,098 participants, 19 countries, 13 languages), adjusting only for current and local currencies while requiring all participants to respond to all items. The results replicated for 94% of items, with some attenuation. Twelve of 13 theoretical contrasts replicated, with 100% replication in some countries. Heterogeneity between countries and intra-individual variation highlight meaningful avenues for future theorizing and applications. We conclude that the empirical foundations for prospect theory replicate beyond any reasonable thresholds. Beyond any reasonable thresholds! IV. Do Nudges Work? or, How Small Is Small? Continuing through the Hreha article: For a number of years, I've been beating the anti-nudge drum. Since 2011, I've been running behavioral experiments in the wild, and have always been struck by how weak nudges tend to be. In my experience, nudges usually fail to have *any* recognizable impact at all. This is supported by a paper that was recently published by a couple of researchers from UC Berkeley. They looked at the results of 126 randomized controlled trials run by two "nudge units" here in the United States. I want you to guess how large of an impact these nudges had on average... 30%? 20%? 10%? 5%? 3%? 1.5%? 1%? 0%? If you said 1.5%, you'd be right (the actual number is 1.4%, but if I had written that out you would have chosen it because of its specificity). According to the academic papers these nudges were based upon, these nudges should have had an average impact of 8.7%. But, as you probably understand by now, behavioral economics is not a particularly trustworthy field. I actually emailed the authors of this paper, and they thought the ~1% effect size of these interventions was something to be applauded—especially if the intervention was cheap & easy. Unfortunately, no intervention is truly cheap or easy. Every single intervention requires, at the very minimum, administrative overhead. If you're going to do something, you need someone (or some system) to implement and keep track of it. If an intervention is only going to get you a 1% improvement, it's probably not even worth it. Uber infamously had a team of behavioral economists working on its product, trying to “nudge” people in the right direction. Relatedly, Uber makes $10 billion in yearly revenue. If they can “nudge” people to spend 1% more, that’s $100 million. That’s not much relative to revenue, but it’s a lot in absolute terms. In particular, it pays the salary of a lot of behavioral economists. If you can hire 10 behavioral economists for $100,000 a year and make $100 million, that’s $99 million in profit. Or what if you’re a government agency, trying to nudge people to do prosocial things? There are about 90 million eligible Americans who haven’t gotten their COVID vaccine, and although some of them are hard-core conspiracy theorists, others are just lazy or nervous or feel safe already. (source) Whoever decided on that grocery gift card scheme was nudging, whether or not they have an economics degree - and apparently they were pretty good at it. If some sort of behavioral econ campaign can convince 1.5% of those 90 million Americans to get their vaccines, that’s 1.4 million more vaccinations and, under reasonable assumptions, maybe a few thousand lives saved. Hreha says that: Every single intervention requires, at the very minimum, administrative overhead. If you're going to do something, you need someone (or some system) to implement and keep track of it. If an intervention is only going to get you a 1% improvement, it's probably not even worth it. This depends on scale! 1% of a small number isn’t worth it! 1% of a big number is very worth it, especially if that big number is a number of lives! A few caveats. First, a small number only matters if it’s real. It’s very easy to get spurious small effects, so much so that any time you see a small effect you should wonder if it’s real. I’m ready to be forgiving here because behavioral economics is so well-replicated and common-sensically true, but I wouldn’t blame anyone who steers clear. Second, Hreha says: To be honest, you can probably use your creativity to brainstorm an idea that will get you a 3-4% minimum gain, no behavioral economics "science" required. Which leads me to the final point I'd like to make: rules and generalizations are overrated. The reason that fields like behavioral economics are so seductive is because they promise people easy, cookie-cutter solutions to complicated problems. Figuring out how to increase sales of your product is hard. You need to figure out which variables are responsible for the lackluster interest. Is the price the issue? Is the product too hard to use? Is the design tacky? Is the sales organization incompetent? Is the refund/return policy lacking? etc. Exploring these questions can take months (or years) of hard work, and there's no guarantee that you'll succeed. If, however, a behavioral economist tells you that there are nudges that will increase your sales by 10%, 20%, or 30% without much effort on your part... Whoa. That's pretty cool. It's salvation. Thus, it's no surprise that governments and companies have spent hundreds of millions of dollars on behavioral "nudge" units. Unfortunately, as we've seen, these nudges are woefully ineffective. Specific problems require specific solutions. They don't require boilerplate solutions based on general principles that someone discovered by studying a bunch of 19 year old college students. However, the social sciences have done a good job of convincing people that general principles are better solutions for problems than creative, situation-specific solutions. In my experience, creative solutions that are tailor-made for the situation at hand *always* perform better than generic solutions based on one study or another. Hreha is a professional in this field, so presumably he’s right. Still, compare to medicine. A thoughtful doctor who tailors treatment to a particular patient sounds better (and is better) than one who says “Depression? Take this one all-purpose depression treatment which is the first thing I saw when I typed ‘depression’ into UpToDate”. But you still need medical journals. Having some idea of general-purpose laws is what gives the people making creative solutions something to build upon. (also, at some point your customers might want to check your creative solution to see whether it actually gives a “3-4% minimum gain, no behavioral economics required”, and that would be at least vaguely study-shaped.) Third, everyone who said nudging had vast effects is still bad and wrong. Many of them were bad and wrong and making fortunes consulting for companies about how to implement the policies they were claiming were super-powerful. This is suspicious and we should lower our opinion of them accordingly. In a previous discussion of growth mindset, I wrote: Imagine I claimed our next-door neighbor was a billionaire oil sheik who kept thousands of boxes of gold and diamonds hidden in his basement. Later we meet the neighbor, and he is the manager of a small bookstore and has a salary 10% above the US average... Should we describe this as “we have confirmed the Wealthy Neighbor Hypothesis, though the effect size was smaller than expected”? Or as “I made up a completely crazy story, and in unrelated news there was an irrelevant deviation from literally-zero in the same space”? All the people talking about oil sheiks deserve to get asked some really uncomfortable questions. And a lot of these will be the most famous researchers - the Dan Arielys of the world - because of course the people who successfully hyped their results a lot are the ones the public knows about. Still, the neighbor seems like a neat guy, and maybe he’ll give you a job at his bookstore. V. Conclusion: Musings On The Identifiable Victim Effect I actually skipped the very beginning of Hreha’s article. I want to come back to it now. It begins: The last few years have been particularly bad for behavioral economics. A number of frequently cited findings have failed to replicate. Here are a couple of high profile examples: The Identifiable Victim Effect (featured in the workbooks I wrote with Dan Ariely and Kristen Berman in 2014)
Inline links: Loss Aversion Has Moderators, But Reports Of Its Death Are Greatly Exaggerated, Alex Imas, Replicating patterns of prospect theory for decision under risk, They looked at the results of 126 randomized controlled trials, others, https://substackcdn.com/image/fetch/$s_!1gY_!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F5b127d7c-045a-4266-b515-a0e9201ce651_571x382.png, a previous discussion of growth mindset, the workbooks I wrote with Dan Ariely and Kristen Berman in 2014
Maybe the real problem here is that we’ve all gotten paranoid. We hear “identifiable victim effect fails to replicate”, and it brings up this whole package of things - power posing, stereotype threat, Dan Ariely, maybe the whole Identifiable Victim industry is a grift, maybe the data is fraudulent, maybe…
Power Rangers1 mentions across 1 issues

Power Rangers is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between September 12, 2025 and September 12, 2025. The archive places it in contexts such as "He likes Power Rangers a lot I think, just like I used to". It most often appears alongside A Change of Heart, Abraham, Adams.

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Power Rangers
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September 12, 2025
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Your Review: The Synaptic Plasticity and Memory Hypothesis
September 12, 2025 · Original source
Some recipients develop aversions after obtaining a new heart. For example, a 5-year-old boy received the heart of a 3-year-old boy but was not told the age or cause of his donor’s death. Still, he offered the following description of his donor following surgery: “He’s just a little kid. He’s a little brother like about half my age. He got hurt bad when he fell down. He likes Power Rangers a lot I think, just like I used to. I don’t like them anymore though”. The donor died after falling from an apartment window while trying to reach a Power Ranger toy that had fallen on the ledge of the window. After receiving his new heart, the recipient would not touch Power Rangers.
Powerball1 mentions across 1 issues

Powerball is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between March 30, 2022 and March 30, 2022. The archive places it in contexts such as "I’m gonna ask each idol for next week’s Powerball numbers". It most often appears alongside Comparative Religion, FAANG, I SOLVED THE RIDDLE OF THE IDOLS.

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Powerball
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1
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March 30, 2022
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March 30, 2022
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Idol Words
March 30, 2022 · Original source
The petitioner, a man with slick blond hair, cut me off. “Ha, no problem! I’m gonna ask each idol for next week’s Powerball numbers, then buy three tickets.” Before I could respond, he shouted “Left idol! What are next week’s winning Powerball numbers?”
“Center idol, what are next week’s winning Powerball numbers?”
“Right idol, what are next week’s winning Powerball numbers?”
Poynting vector1 mentions across 1 issues

Poynting vector is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between November 08, 2022 and November 08, 2022. The archive places it in contexts such as "The vector describing the direction ... is called the Poynting vector, after John Henry Poynting". It most often appears alongside Alexander Buhl, ANNs, Bay Area House Party.

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Poynting vector
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1
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November 08, 2022
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November 08, 2022
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Highlights From The Comments On Brain Waves
November 08, 2022 · Original source
The vector describing the direction in which an electromagnetic field's energy flow is pointing is called the Poynting vector, after John Henry Poynting.
PPD1 mentions across 1 issues

PPD is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between March 16, 2022 and March 16, 2022. The archive places it in contexts such as "This paper confirms that women with PMDD or PPD"; "women with PMDD or PPD (but not other women) get tolerance". It most often appears alongside 5α-reductase inhibitor, A Mindful Monkey, ALLO.

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PPD
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March 16, 2022
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Highlights From The Comments On Zulresso
March 16, 2022 · Original source
This paper confirms that women with PMDD or PPD (but not other women) get tolerance to allopregnanolone within the normal course of the menstrual cycle or pregnancy. There’s actually a study showing that these women get less effect from benzos during this time, since the allopregnanolone and benzos have cross-tolerance!
Prader-Willi syndrome1 mentions across 1 issues

Prader-Willi syndrome is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between June 29, 2023 and June 29, 2023. The archive places it in contexts such as "Prader-Willi syndrome, caused by damage to a region of chromosome 15". It most often appears alongside Bryan, Bryan Caplan, C-SPAN.

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Prader-Willi syndrome
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June 29, 2023
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Sure, Whatever, Let's Try Another Contra Caplan On Mental Illness
June 29, 2023 · Original source
Liking Pepsi more than Coke. You could think of this as a preference for drinking Pepsi over drinking Coke - or as an internal state marked by a strong repulsion to Coke plus a strong attraction to Pepsi. In the first two situations, it’s much more natural to use internal-state language, and in the sixth, it’s much more natural to use preference language. The middle three aren’t obvious, which is why we’re having this debate. The Buddhists say desire is suffering, and sometimes this is literally true. An itch is the clearest example; it’s in an almost perfect superposition between raw suffering and pure desire (to scratch yourself). Is it a preference or a constraint? It’s both - a preference to scratch one’s self, and a constraint to be forced to feel suffering if you don’t scratch yourself. While the person may choose whether or not to scratch themselves, they cannot choose whether or not to feel the suffering. Put a gun to their head and say “stop feeling suffering when you don’t scratch yourself” and they will have no choice but to die. It’s possible, although bizarre, to think of normal preferences like the preference for Pepsi over Coke this way. You could say “this person has the constraint that they will feel suffering when they are forced to drink Coke instead of Pepsi”. It’s not very useful. But it’s possible. Whether it’s more useful to think of any given situation as a preference or a constraint depends on things like whether you can easily satisfy the preference, whether the preference is ego-syntonic or ego-dystonic, and whether it seems normal by social standards. Consider Prader-Willi syndrome, caused by damage to a region of chromosome 15. Symptoms tend to include short limbs, mental retardation, and extreme hunger. Here’s how the NYT describes this last problem (content warning for body horror): One result is a heightened, permanent sensation of hunger. “They describe it as physical pain,” Jennifer Miller, an endocrinologist at the University of Florida who treats children with Prader-­Willi, told me. “They feel like they’re going to die if they don’t get food. They’re starving.” Parents must lock their pantries, refrigerators and trash cans, and their children frequently lie and steal to get something to eat. They have been known to memorize credit-card numbers and secretly phone for delivery, use a drill to remove the door from a locked refrigerator and break into a neighbor’s garage and eat, uncooked, an entire frozen pizza. And here’s how it describes one particular patient’s last moments: In 2004, Peter and Gayle Girard held their annual Christmas Eve party for family members at their home in Orlando, Fla. Before dinner, they set out chips, vegetables and dip, shrimp, a bowl of punch and sodas. Their 17-year-old son, Jeremy, had Prader-­Willi, and they often hosted events at their home so he could join in while they kept an eye on him — as they believed they were doing that night. But the next morning, Jeremy’s belly was distended, and he complained of pain. At the emergency room, doctors pumped his stomach, but his condition worsened. A day passed before surgeons discovered that his stomach, which had been distended long enough to lose blood flow and become septic, had ruptured. Jeremy died that night. Only afterward did the Girards learn that other family members saw him eating more than he should have but didn’t alert them. I insist on calling Prader-Willi syndrome a disease, and a serious one, even though the extreme hunger of Prader-Willi is continuous with/shades into the normal hunger where I would like a slice of pizza. My preference for pizza is so easily satisfied that it rarely bothers me. It’s ego syntonic - I am fine with being the sort of person who likes pizza. It’s socially normal - everyone likes pizza. It doesn’t cause much trouble - it wouldn’t improve my life much if I stopped wanting pizza. So I think of it as a preference. If it were otherwise - the extreme hunger of someone with Prader-Willi - it would be more natural to talk about it as a compulsion, a sense of extreme pain inflicted on me when I wasn’t eating enough, something ontologically similar to a stomach flu that also produces extreme pain in the abdominal region. IV. None of this really addresses Caplan’s most recent post, which is, I think, a much worse point. His current post says that either you have to believe that mental illness doesn’t exist and is just voluntary preferences which are stigmatized by society, or you have to believe that homosexuality is objectively a mental illness. Not only are each of these incoherent ideas, they’re not even the same incoherent idea! You could easily accept one of the incoherent ideas and reject the other! Consider the following three positions: Down’s Syndrome is a terrible disease that inflicts vast suffering on its victims. Also it inflicts suffering on society by making people unproductive. We should be very angry about this, and do everything we can do make people with Down’s Syndrome normal.
Inline links: Here’s how the NYT describes
PRAX1 mentions across 1 issues

PRAX is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between December 06, 2021 and December 06, 2021. The archive places it in contexts such as "getting a currency called PRAX for completing tasks". It most often appears alongside ACX Grants, Akon, Akon City.

Reference entry
PRAX
Mention count
1
Issue count
1
First seen
December 06, 2021
Last seen
December 06, 2021
Outbound links
Issue trail
  • 21 December 06, 2021
Related pages
Source context
21
December 06, 2021 · Original source
Second, Bitcoin miners don’t want a city the shape of a Bitcoin with a central plaza in the shape of a Bitcoin logo. They want cheap electricity. Bukele has promised that there will be cheap geothermal power from the volcano, which sounds good, but this article says El Salvador’s existing geothermal energy costs about 12 cents/kilowatt-hour, much higher than the 4 cents/megawatt-hour miners can get in the current cheapest areas. Maybe El Salvador could do a really good job upgrading their energy infrastructure, but at some point you’re subsidizing this rather than using it as a cash cow. And third, this isn’t even the stupidest plan to build a cryptocurrency-themed city in the Third World. That arguably goes to Akon City, a thing where a pop singer named Akon was going to build a cryptocurrency city in Senegal. Now, without any construction having started, they’re planning to build a second one in Uganda! All competing for the same handful of crypto companies! But I looked into Bukele to see if he was a moron with a habit of coming up with terrible ideas. It seems like no. He rose from nothing to become El Salvador’s first outside-the-traditional-party-system president, and has an approval rating of around 90%. And apparently he’s presided over a historic drop in the homicide rate of this previously murder-capital-of-the-world country. Although I’m betting that one day he’ll make a great Dictator Book Club entry, I’m prepared to give him the benefit of the doubt on “doesn’t do stupid things for no reason” What’s the non-stupid explanation for this? Maybe it’s supposed to be a signal. You can give up 5% of the way through, but even trying to build a Bitcoin-shaped city at least shows very conclusively that you’ve got a crypto-friendly regulatory climate, so many easily-spooked crypto companies will flock to you. This makes sense in the context of big crypto companies moving to the Caribbean for regulatory reasons, eg FTX moving to the Bahamas and Binance moving to the Cayman Islands. But if I understand correctly, both of these companies make on the order of $1 billion a year. If El Salvador can tax them at 5% (dubious, since a big part of promising a friendly regulatory climate is low taxes), that’s still only $100 million if they can capture both of them. Which they can’t, because these companies seem happy where they are. And I don’t think there are a lot of similarly-sized crypto companies looking for Central American homes that I don’t know about. And even though El Salvador is pretty poor, it’s not so poor that $100 million is worth embarrassing themselves over. So I’m stumped. EDIT: See this comment. Praxis, aka Bluebook Cities, the Internet Speaking of stumped, who are these people? Right now, they’re a web page with a lot of buzz promising the City Of The Future, in very poetic language: Praxis is a grassroots movement of modern pioneers building a new city. We are technologists and artists, builders and dreamers. We are building a place where we can develop to our fullest potentials, physically, culturally, and spiritually. Bitcoin was developed as a financial technology with political goals identical to those of the Founding Fathers: liberation. The ultimate end of crypto is the possibility of a future for humanity unshackled from the institutions that seek to limit our growth. Our ultimate goal is to bring about a more vital future for humanity, and we will use technology to achieve this righteous end. Our civilization is unwell. We eat food that kills us, we’ve lost sight of beauty, and we neglect our spiritual lives. The world is deranged and decayed, and this frightens people. We don’t look up from our screens; we seek to live within them. Crypto is a fundamentally political technology -- escape to the metaverse is a betrayal of the principles on which it was founded. We are descended from the people who built Rome and Athens, who dared to split atoms and voyage to the Moon. We can build new worlds not just of bits, but of atoms. But where is this city? What will its policies be? As we leave old lands, our values are our compass. Like wolves, tribes of pioneers are muscular by necessity. For voyaging tribes to settle, they must perform murmurations: intricate coordination with little communication, at scale. This is only possible with a strong sense of asabiyya (group feeling derived from deeply-held shared values). Our values inform the destiny we desire, and for which we struggle. Asabiyya is forged in this struggle. With asabiyya, pioneers can earn the divine mandate to build a city. Cities are the fount of human ingenuity. In cities, people enjoy their fullest potential by contributing their resources under the auspices of civilization. Who even are you? What experience do you have with city-building? Civilizations rise and fall. All around us, we see civilizational decay. The people are not vital: physically, culturally, spiritually. We live in an era of obesity, remakes, and pollution. We are losing the divine mandate, and in an era of absolute weapons, what’s at stake is everything. But perhaps there’s some glory in death by a light brighter than a thousand suns. A worse fate may await humanity: atrophied bodies submerged in gel, fed synthetic bug paste, minds occupied by the petty amusements of a corporate metaverse. There, nothing is at stake; there are no frontiers to explore; no growth is possible. Nothing to live for, and nothing to die for. As we walk between these twin fates, the light of our civilization dims. But beyond the horizon, we see a new light emerging. Like the sun at dawn, it cannot be stopped. Vitality itself is the foundational value of this new civilizational form, and we have the technology to enact our moral imperative as never before. You’re not answering my…okay, fine, whatever, forget it. As far as I can tell, Praxis is two 25-year-olds with no previous experience, armed with about $10 million in Peter Thiel’s money. Peter Thiel is a smart person known for having good business sense, but he’s also known to have a weakness for young people who dream big and sound like purveyors of esoteric secrets. I wonder if the simplest explanation is just that this is one of the cases where his weakness got the better of his sense, and now these two random people have $10 million earmarked for building a city, and no idea what to do. [CORRECTION: some people involved in Praxis have reached out to tell me that it was $4 million instead of $10 million, and that it was Thiel-backed Pronomos and not Thiel himself. I’ll be getting in touch with them to learn if there are other issues or things I should correct here] But that’s not how they put it! The way they put it is - all previous charter city founders have started by approaching governments and pitching their ideas. But there’s a chicken-and-egg problem: governments don’t want to give land to a purely hypothetical city that might not pan out, and the city can’t pan out until governments give it land. Praxis’ plan is to build the community first, then go to a government saying “Here’s 50,000 people who have agreed to join our city, and lots of businesses and organizations that are excited about it. Please give us land for our guaranteed-success, concretely-existing project.” Now this is a different chicken-and-egg problem: why join a community of people with no land and no plans? Praxis writes: What if we try to draw people to new cities not on an economic basis, but rather on a spiritual one? Which city (or country) founding projects have succeeded that have drawn people on a predominantly non-economic, but rather spiritual basis? Among others, Israel and America. Both groups were oppressed, and sought the freedom to live by their values. Both felt the intangible pull of the frontier. Both had a keen historical instinct. This is how cities with spiritual significance are founded. The correct approach to city building in this new world is demand-first (or as Balaji Srinivasan calls it, Cloud City first). We build the citizenry before the city. First, we create communities of true believers, organized around shared values, online. People move to cities for people, and it follows that if you collect a group of people who all want to live together, they’ll all move together if at a moment in time everyone else does, too. Today, we have new tools. The emergence of Web3 enables us to supercharge communities with self-ownership, governance, and determination. Once you build a community of people ready to move to a new city together, you can self-finance the entire project. With something real to offer nations, conversations with governments become productive (e.g. Gigafactory). That’s how you make the risk dominoes fall. The problem is, Israel worked because it had Judaism. Judaism is a very specific belief. Prospera is specifically libertarian, Telosa is specifically Georgist, and even the Bitcoin-shaped volcano city knows what it’s about. What is Praxis? The use of “atrophied bodies submerged in gel, fed synthetic bug paste” as a warning reads very slightly right-wing to me - there’s a right-wing meme about how the media keeps trying to get people to eat bugs, and how this is the shape our future dystopia will take. But whether I’m right or wrong, the fact that it’s hard to tell is a problem. The only other clues we’re getting are their Discord, which seems to be focused around getting a currency called PRAX for completing tasks. Once you get enough, you can become a Member, which seems to be where the real excitement starts. (source) I’m not even being sarcastic - I expect being a member to be quite fun. I say this because when I was a teenager I was part of a bunch of country simulation projects, some of which got past the inherent nerdiness of being a country simulation project exactly the same way Praxis is doing it - by saying that we were going to become a real country someday, as soon as we were big enough to convince people. These were usually fun and interesting and educational, and I made lots of great like-minded teenage and twenty-something friends. But none of them ever came close to becoming a real country, and I’m not sure it was merely for lack of millions of dollars. I hope I’m wrong and they manage to forge new lands through struggle to uplift the human spirit or whatever. Elsewhere In Model Cities Vitalik Buterin on the intersection between local government and blockchain technologies. He recommends they “start with self-contained experiments, and take things slowly on moves that are truly irreversible”, which is a weird way of saying “what we crypto leaders really want is a city at the base of a volcano, shaped like a giant Bitcoin”.
Inline links: with a central plaza in the shape of a Bitcoin logo, this article, Akon City, a second one, Bukele, a historic drop in the homicide rate, Dictator Book Club, moving to the Bahamas, moving to the Cayman Islands, this comment, promising the City Of The Future, far as I can tell, the media keeps trying, their Discord, tasks, https://substackcdn.com/image/fetch/$s_!2TK6!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F020ebe08-e968-45cd-ba39-a91cdc6e5892_473x533.png, source, a bunch of country simulation projects, the intersection between local government and blockchain technologies
(source) I’m not even being sarcastic - I expect being a member to be quite fun. I say this because when I was a teenager I was part of a bunch of country simulation projects, some of which got past the inherent nerdiness of being a country simulation project exactly the same way Praxis is doing it - by saying that we were going to become a real country someday, as soon as we were big enough to convince people. These were usually fun and interesting and educational, and I made lots of great like-minded teenage and twenty-something friends. But none of them ever came close to becoming a real country, and I’m not sure it was merely for lack of millions of dollars. I hope I’m wrong and they manage to forge new lands through struggle to uplift the human spirit or whatever. Elsewhere In Model Cities Vitalik Buterin on the intersection between local government and blockchain technologies. He recommends they “start with self-contained experiments, and take things slowly on moves that are truly irreversible”, which is a weird way of saying “what we crypto leaders really want is a city at the base of a volcano, shaped like a giant Bitcoin”.
Inline links: source, a bunch of country simulation projects, the intersection between local government and blockchain technologies
Praxis1 mentions across 1 issues

Praxis is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between December 06, 2021 and December 06, 2021. The archive places it in contexts such as "some of which got past the inherent nerdiness of being a country simulation project exactly the same way Praxis is doing it". It most often appears alongside ACX Grants, Akon, Akon City.

Reference entry
Praxis
Mention count
1
Issue count
1
First seen
December 06, 2021
Last seen
December 06, 2021
Outbound links
Issue trail
  • 21 December 06, 2021
Related pages
Source context
21
December 06, 2021 · Original source
Second, Bitcoin miners don’t want a city the shape of a Bitcoin with a central plaza in the shape of a Bitcoin logo. They want cheap electricity. Bukele has promised that there will be cheap geothermal power from the volcano, which sounds good, but this article says El Salvador’s existing geothermal energy costs about 12 cents/kilowatt-hour, much higher than the 4 cents/megawatt-hour miners can get in the current cheapest areas. Maybe El Salvador could do a really good job upgrading their energy infrastructure, but at some point you’re subsidizing this rather than using it as a cash cow. And third, this isn’t even the stupidest plan to build a cryptocurrency-themed city in the Third World. That arguably goes to Akon City, a thing where a pop singer named Akon was going to build a cryptocurrency city in Senegal. Now, without any construction having started, they’re planning to build a second one in Uganda! All competing for the same handful of crypto companies! But I looked into Bukele to see if he was a moron with a habit of coming up with terrible ideas. It seems like no. He rose from nothing to become El Salvador’s first outside-the-traditional-party-system president, and has an approval rating of around 90%. And apparently he’s presided over a historic drop in the homicide rate of this previously murder-capital-of-the-world country. Although I’m betting that one day he’ll make a great Dictator Book Club entry, I’m prepared to give him the benefit of the doubt on “doesn’t do stupid things for no reason” What’s the non-stupid explanation for this? Maybe it’s supposed to be a signal. You can give up 5% of the way through, but even trying to build a Bitcoin-shaped city at least shows very conclusively that you’ve got a crypto-friendly regulatory climate, so many easily-spooked crypto companies will flock to you. This makes sense in the context of big crypto companies moving to the Caribbean for regulatory reasons, eg FTX moving to the Bahamas and Binance moving to the Cayman Islands. But if I understand correctly, both of these companies make on the order of $1 billion a year. If El Salvador can tax them at 5% (dubious, since a big part of promising a friendly regulatory climate is low taxes), that’s still only $100 million if they can capture both of them. Which they can’t, because these companies seem happy where they are. And I don’t think there are a lot of similarly-sized crypto companies looking for Central American homes that I don’t know about. And even though El Salvador is pretty poor, it’s not so poor that $100 million is worth embarrassing themselves over. So I’m stumped. EDIT: See this comment. Praxis, aka Bluebook Cities, the Internet Speaking of stumped, who are these people? Right now, they’re a web page with a lot of buzz promising the City Of The Future, in very poetic language: Praxis is a grassroots movement of modern pioneers building a new city. We are technologists and artists, builders and dreamers. We are building a place where we can develop to our fullest potentials, physically, culturally, and spiritually. Bitcoin was developed as a financial technology with political goals identical to those of the Founding Fathers: liberation. The ultimate end of crypto is the possibility of a future for humanity unshackled from the institutions that seek to limit our growth. Our ultimate goal is to bring about a more vital future for humanity, and we will use technology to achieve this righteous end. Our civilization is unwell. We eat food that kills us, we’ve lost sight of beauty, and we neglect our spiritual lives. The world is deranged and decayed, and this frightens people. We don’t look up from our screens; we seek to live within them. Crypto is a fundamentally political technology -- escape to the metaverse is a betrayal of the principles on which it was founded. We are descended from the people who built Rome and Athens, who dared to split atoms and voyage to the Moon. We can build new worlds not just of bits, but of atoms. But where is this city? What will its policies be? As we leave old lands, our values are our compass. Like wolves, tribes of pioneers are muscular by necessity. For voyaging tribes to settle, they must perform murmurations: intricate coordination with little communication, at scale. This is only possible with a strong sense of asabiyya (group feeling derived from deeply-held shared values). Our values inform the destiny we desire, and for which we struggle. Asabiyya is forged in this struggle. With asabiyya, pioneers can earn the divine mandate to build a city. Cities are the fount of human ingenuity. In cities, people enjoy their fullest potential by contributing their resources under the auspices of civilization. Who even are you? What experience do you have with city-building? Civilizations rise and fall. All around us, we see civilizational decay. The people are not vital: physically, culturally, spiritually. We live in an era of obesity, remakes, and pollution. We are losing the divine mandate, and in an era of absolute weapons, what’s at stake is everything. But perhaps there’s some glory in death by a light brighter than a thousand suns. A worse fate may await humanity: atrophied bodies submerged in gel, fed synthetic bug paste, minds occupied by the petty amusements of a corporate metaverse. There, nothing is at stake; there are no frontiers to explore; no growth is possible. Nothing to live for, and nothing to die for. As we walk between these twin fates, the light of our civilization dims. But beyond the horizon, we see a new light emerging. Like the sun at dawn, it cannot be stopped. Vitality itself is the foundational value of this new civilizational form, and we have the technology to enact our moral imperative as never before. You’re not answering my…okay, fine, whatever, forget it. As far as I can tell, Praxis is two 25-year-olds with no previous experience, armed with about $10 million in Peter Thiel’s money. Peter Thiel is a smart person known for having good business sense, but he’s also known to have a weakness for young people who dream big and sound like purveyors of esoteric secrets. I wonder if the simplest explanation is just that this is one of the cases where his weakness got the better of his sense, and now these two random people have $10 million earmarked for building a city, and no idea what to do. [CORRECTION: some people involved in Praxis have reached out to tell me that it was $4 million instead of $10 million, and that it was Thiel-backed Pronomos and not Thiel himself. I’ll be getting in touch with them to learn if there are other issues or things I should correct here] But that’s not how they put it! The way they put it is - all previous charter city founders have started by approaching governments and pitching their ideas. But there’s a chicken-and-egg problem: governments don’t want to give land to a purely hypothetical city that might not pan out, and the city can’t pan out until governments give it land. Praxis’ plan is to build the community first, then go to a government saying “Here’s 50,000 people who have agreed to join our city, and lots of businesses and organizations that are excited about it. Please give us land for our guaranteed-success, concretely-existing project.” Now this is a different chicken-and-egg problem: why join a community of people with no land and no plans? Praxis writes: What if we try to draw people to new cities not on an economic basis, but rather on a spiritual one? Which city (or country) founding projects have succeeded that have drawn people on a predominantly non-economic, but rather spiritual basis? Among others, Israel and America. Both groups were oppressed, and sought the freedom to live by their values. Both felt the intangible pull of the frontier. Both had a keen historical instinct. This is how cities with spiritual significance are founded. The correct approach to city building in this new world is demand-first (or as Balaji Srinivasan calls it, Cloud City first). We build the citizenry before the city. First, we create communities of true believers, organized around shared values, online. People move to cities for people, and it follows that if you collect a group of people who all want to live together, they’ll all move together if at a moment in time everyone else does, too. Today, we have new tools. The emergence of Web3 enables us to supercharge communities with self-ownership, governance, and determination. Once you build a community of people ready to move to a new city together, you can self-finance the entire project. With something real to offer nations, conversations with governments become productive (e.g. Gigafactory). That’s how you make the risk dominoes fall. The problem is, Israel worked because it had Judaism. Judaism is a very specific belief. Prospera is specifically libertarian, Telosa is specifically Georgist, and even the Bitcoin-shaped volcano city knows what it’s about. What is Praxis? The use of “atrophied bodies submerged in gel, fed synthetic bug paste” as a warning reads very slightly right-wing to me - there’s a right-wing meme about how the media keeps trying to get people to eat bugs, and how this is the shape our future dystopia will take. But whether I’m right or wrong, the fact that it’s hard to tell is a problem. The only other clues we’re getting are their Discord, which seems to be focused around getting a currency called PRAX for completing tasks. Once you get enough, you can become a Member, which seems to be where the real excitement starts. (source) I’m not even being sarcastic - I expect being a member to be quite fun. I say this because when I was a teenager I was part of a bunch of country simulation projects, some of which got past the inherent nerdiness of being a country simulation project exactly the same way Praxis is doing it - by saying that we were going to become a real country someday, as soon as we were big enough to convince people. These were usually fun and interesting and educational, and I made lots of great like-minded teenage and twenty-something friends. But none of them ever came close to becoming a real country, and I’m not sure it was merely for lack of millions of dollars. I hope I’m wrong and they manage to forge new lands through struggle to uplift the human spirit or whatever. Elsewhere In Model Cities Vitalik Buterin on the intersection between local government and blockchain technologies. He recommends they “start with self-contained experiments, and take things slowly on moves that are truly irreversible”, which is a weird way of saying “what we crypto leaders really want is a city at the base of a volcano, shaped like a giant Bitcoin”.
Inline links: with a central plaza in the shape of a Bitcoin logo, this article, Akon City, a second one, Bukele, a historic drop in the homicide rate, Dictator Book Club, moving to the Bahamas, moving to the Cayman Islands, this comment, promising the City Of The Future, far as I can tell, the media keeps trying, their Discord, tasks, https://substackcdn.com/image/fetch/$s_!2TK6!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F020ebe08-e968-45cd-ba39-a91cdc6e5892_473x533.png, source, a bunch of country simulation projects, the intersection between local government and blockchain technologies
(source) I’m not even being sarcastic - I expect being a member to be quite fun. I say this because when I was a teenager I was part of a bunch of country simulation projects, some of which got past the inherent nerdiness of being a country simulation project exactly the same way Praxis is doing it - by saying that we were going to become a real country someday, as soon as we were big enough to convince people. These were usually fun and interesting and educational, and I made lots of great like-minded teenage and twenty-something friends. But none of them ever came close to becoming a real country, and I’m not sure it was merely for lack of millions of dollars. I hope I’m wrong and they manage to forge new lands through struggle to uplift the human spirit or whatever. Elsewhere In Model Cities Vitalik Buterin on the intersection between local government and blockchain technologies. He recommends they “start with self-contained experiments, and take things slowly on moves that are truly irreversible”, which is a weird way of saying “what we crypto leaders really want is a city at the base of a volcano, shaped like a giant Bitcoin”.
Inline links: source, a bunch of country simulation projects, the intersection between local government and blockchain technologies
prazosin1 mentions across 1 issues

prazosin is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between June 16, 2022 and June 16, 2022. The archive places it in contexts such as "The standard of care is prazosin, an alpha-blocker". It most often appears alongside Amazon, clonidine, Dr. Justin Havens.

Reference entry
prazosin
Mention count
1
Issue count
1
First seen
June 16, 2022
Last seen
June 16, 2022
Outbound links
Issue trail
Related pages
Source context
Peer Review: Nightmares
June 16, 2022 · Original source
Summary: Nightmares happen when the process of dream generation is biased by ambient stress - or sometimes for other reasons. Anything that decreases stress, increases comfort while sleeping, and deepens sleep quality will also improve nightmares, including colder, darker rooms, less indigestion, and treating any comorbid psychiatric or medical conditions. If that doesn’t work, several kinds of therapy - including Image Rehearsal Therapy, Systematic Desensitization, and Lucid Dreaming - may be helpful. Prazosin is the standard anti-nightmare drug, and can be taken at doses from 1 - 12 mg, but watch out for side effects.
We’ll look at a few of these further: Desensitization and LDT, the two highest-performing therapies. IRT, the best-studied therapy. And prazosin, the highest-performing medication.
The standard of care is prazosin, an alpha-blocker. Here is a good review study.
Inline links: Here
PRDM91 mentions across 1 issues

PRDM9 is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between June 18, 2025 and June 18, 2025. The archive places it in contexts such as "activation of downstream meiotic genes including PRDM9". It most often appears alongside 1DaySooner, Aatu Koskensilta, acanthamoeba keratitis.

Reference entry
PRDM9
Mention count
1
Issue count
1
First seen
June 18, 2025
Last seen
June 18, 2025
Outbound links
Issue trail
Related pages
Source context
ACX Grants 1-3 Year Updates
June 18, 2025 · Original source
Our project has made significant progress in inducing meiosis in arbitrary cell types, a critical step in gametogenesis. We've successfully identified and validated key transcription factors (STRA8, etc.) that drive meiotic gene expression in human cells, with our experiments demonstrating consistent activation of downstream meiotic genes including SYCP3, SYCP2, PRDM9 and SMC1B. Using nucleofection techniques and small molecule treatments, we've optimized protocols that enhance meiotic gene expression up to 800-fold in iPSCs and primary cells. Our RNA-seq analysis has identified specific induction conditions that most effectively initiate the meiotic program, and we're currently refining our protocols to achieve complete meiotic progression to full completion to generate recombinant haploids.
Inline links: Our project
pre-agriculture Europeans1 mentions across 1 issues

pre-agriculture Europeans is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between January 16, 2025 and January 16, 2025. The archive places it in contexts such as "pre-agriculture Europeans had genetic IQ of 90". It most often appears alongside Afghanistan, Africa, African small-plot subsistence agriculture.

Mention count
1
Issue count
1
First seen
January 16, 2025
Last seen
January 16, 2025
Outbound links
Issue trail
Related pages
Source context
Highlights From The Comments On Lynn And IQ
January 16, 2025 · Original source
First, he corrected my misconception about Reich on ancient European cognitive evolution. Reich had said that pre-agriculture Europeans were “2-3 standard deviations” below moderns. I had interpreted that as IQ deviations of 15 points, making them genetic IQ 55-70, which would have been pretty crazy. Stone tells me he actually meant PGS deviations, each of which was about 3-4 IQ points, so he’s claiming that pre-agriculture Europeans had genetic IQ of 90 (they probably also had lower IQ for environmental reasons).,
pre-colonial African art1 mentions across 1 issues

pre-colonial African art is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between October 04, 2021 and October 04, 2021. The archive places it in contexts such as "the very few pieces of pre-colonial African art (pre-1500 CE)". It most often appears alongside 19th century African art, 20th century, 9-11.

Mention count
1
Issue count
1
First seen
October 04, 2021
Last seen
October 04, 2021
Outbound links
Issue trail
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Source context
Highlights From The Comments On Modern Architecture
October 04, 2021 · Original source
- 19th century African art, which is what everyone today thinks of as "African art", is nearly all highly abstract and anti-naturalistic (and was also a big influence on modern art). Yet the very few pieces of pre-colonial African art (pre-1500 CE) which we have are more naturalistic and technically sophisticated, including a few (from present-day Nigeria) that were more skillfully made than their European contemporaries. I've even seen a series of statues made in Benin, from IIRC 1400 to 1900 AD, which show the gradual loss of realism and heightening abstraction.
pre-Columbian America1 mentions across 1 issues

pre-Columbian America is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between August 11, 2023 and August 11, 2023. The archive places it in contexts such as "perhaps something about pre-Columbian America whose stories were traumatically ended". It most often appears alongside Achilles, ACX, Adam Smith.

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pre-Columbian America
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Your Book Review: The Weirdest People in the World
August 11, 2023 · Original source
A big silent intellectual change of the past quarter century is the broadening of our self-concept. Educated Westerners are starting to expect each other to know Chinese and Islamic history, which are still ongoing, and perhaps something about pre-Columbian America whose stories were traumatically ended by the conquest of the New World. The earlier past is moving into the light, too. Ancient states like Babylon and Egypt are gradually coming alive: Hammurabi and Gilgamesh get more play relative to Solon and Achilles. And before that, the real prehistory of the first cities, the Neolithic, the growth of agriculture, the end of the Ice Age at 10,000 BC, modern humans around 100,000 BC, the first humans at 1mya (million years ago)… these dates are gradually getting fixed in the mind as turning points in the story of us.
Inline links: story of us
pre-Raphaelite1 mentions across 1 issues

pre-Raphaelite is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between June 20, 2024 and June 20, 2024. The archive places it in contexts such as "painting pre-Raphaelite art hearkening back to the early Renaissance". It most often appears alongside 1950s family structure, al-Andalus, Druids.

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pre-Raphaelite
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Fake Tradition Is Traditional
June 20, 2024 · Original source
Modern traditionalists look back fondly on Victorian times. But the Victorians didn’t get their culture by just doing stuff without ever thinking of the past. They were writing pseudo-Arthurian poetry, building neo-Gothic palaces, and painting pre-Raphaelite art hearkening back to the early Renaissance. And the Renaissance itself was based on the idea of a re-naissance of Greco-Roman culture. And the Roman Empire at its peak spent half of its cultural energy obsessing over restoring the virtue of the ancient days of the Roman Republic:
Pre-WWI system1 mentions across 1 issues

Pre-WWI system is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between April 06, 2022 and April 06, 2022. The archive places it in contexts such as "Moldbug’s claim that the pre-WWI system was good at preventing wars and atrocities". It most often appears alongside 19th century, 21st century, Africa.

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Pre-WWI system
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Highlights From The Comments On Self-Determination
April 06, 2022 · Original source
This ties into a lot of other UR assumptions I can’t argue with in the depth they deserve here. A poor and unfair summary might be: I actually don’t want countries doing as much genocide and repression as they want, and I think historic attempts to pressure them not to do these things have often been successful (though it’s hard to count since we don’t record atrocities that don’t happen). Rebels will absolutely rebel even in the absence of domestic and foreign aid, and have done so from the Zealots to the Taiping Rebellion through today. Moldbug’s claim that the pre-WWI system was good at preventing wars and atrocities is dubious given how many wars and atrocities there were before WWI (I would guess eg more conflict deaths per capita in the 19th century than the 21st, although I know this sort of thing is hard to quantify).
predatory largemouth bass1 mentions across 1 issues

predatory largemouth bass is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between February 03, 2021 and February 03, 2021. The archive places it in contexts such as "observed in dynamical systems as diverse as predatory largemouth bass populations". It most often appears alongside 2020, Alien Planetwatchers Association, America.

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Ontology Of Psychiatric Conditions: Dynamical Systems
February 03, 2021 · Original source
Put the ball anywhere on the terrain, and it will slide back into the nearest attractor basin. But at different places, it will roll at different rates. On a steep slope, it will roll very quickly; on near-level ground, it will roll more slowly to start with. This is the phenomenon of critical slowing-down, observed in dynamical systems as diverse as predatory largemouth bass populations and the global economy. Borsboom et al find it also applies to depression: when someone is right at the threshold for being depressed, their mood is unusually stable for a short period before finally collapsing into depression or normalcy.
Inline links: critical slowing-down, the global economy, their mood is unusually stable for a short period
prediction market1 mentions across 1 issues

prediction market is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between September 08, 2023 and September 08, 2023. The archive places it in contexts such as "There’s a prediction market , but please don’t peek at it until after you’ve voted". It most often appears alongside Cities And The Wealth Of Nations / The Question Of Separatism, Lying For Money, Man’s Search for Meaning.

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prediction market
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Vote In The 2023 Book Review Contest
September 08, 2023 · Original source
Update: There’s a prediction market, but please don’t peek at it until after you’ve voted.
Inline links: a prediction market
preference utilitarianism1 mentions across 1 issues

preference utilitarianism is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between May 15, 2024 and May 15, 2024. The archive places it in contexts such as "but also with preference utilitarianism". It most often appears alongside @the_megabase, A Pan-Species Welfare State, ACX Grantees.

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Profile: The Far Out Initiative
May 15, 2024 · Original source
Naturally, superhappiness scenarios could be misconceived. Long-range prediction is normally a fool's game. But it's worth noting that future life based on gradients of intelligent bliss isn't tied to any particular ethical theory: its assumptions are quite weak. Radical recalibration of the hedonic treadmill is consistent not just with classical or negative utilitarianism, but also with preference utilitarianism, Aristotelian virtue theory, a deontological or a pluralist ethic, Buddhism, and many other value systems besides.
pregnant woman’s stress1 mentions across 1 issues

pregnant woman’s stress is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between April 13, 2022 and April 13, 2022. The archive places it in contexts such as "A pregnant woman’s stress is generally considered to have negative effects on the fetus". It most often appears alongside acetaminophen, ADHD, Arthur Jensen.

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Obscure Pregnancy Interventions: Much More Than You Wanted To Know
April 13, 2022 · Original source
A pregnant woman’s stress is generally considered to have negative effects on the fetus.
Second caveat: almost every topic we investigate, including this one, will be confounded by genetics. Pregnant mothers will do something, and then their child will be a certain way, and people will want to say it was because they did the thing, but it might just be genetic. For example, consider the claim that maternal stress during pregnancy makes children develop anxiety disorders. You survey a thousand mothers, you see which ones are stressed during pregnancy, then thirty years later you check if those mothers’ kids have more anxiety disorders. They will, but anxiety disorders are genetic. If your mother was stressed during pregnancy, maybe it’s because she has a genetic tendency towards stress, which you inherit, and then you’re stressed all the time too. This can be more subtle: for example, what if we find that maternal stress decreases child IQ? It could be causal. Or it could be that low-IQ people make worse decisions, that means they end up in more stressful situations, and then pass those low-IQ genes on to their kids.
Third, closely related caveat: this whole field gets very political. You can use maternal stress to support “cycle of poverty” narratives where children in poor families “never had a chance”; their mothers were so stressed during pregnancy that their brains developed wrong, meaning they can’t be expected to succeed like other people. A lot of people are really attached to this idea, that makes them less willing to challenge studies that support it, and a lot of unusually bad ones get through.
Premenstrual Dysm1 mentions across 1 issues

Premenstrual Dysm is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between February 22, 2023 and February 22, 2023. The archive places it in contexts such as "included in the 1994 edition of the DSM-IV under the name Premenstrual Dysm". It most often appears alongside Africa, Agin, American.

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Premenstrual Dysm
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Book Review: The Geography Of Madness
February 22, 2023 · Original source
This image (source) of a witch stealing a man’s penis, with a box of previously-stolen penises to her right accompanies the 1411 poem “Flowers Of Virtue” in its 1486 edition. Malleus Maleficarum was published in 1486, so if the original text of Flowers Of Virtue contained the incident this picture refers to, it would predate Malleus. But the original text is written in poetic medieval German and I can’t find a good translation. When I wrote my review of the Malleus, people were surprised at the penis-stealing witch chapters. Yet nothing could possibly be less surprising; the penis-stealing witches are timeless and omnipresent. When commenters continued to doubt, I promised them this review of Frank Bures’ Geography Of Madness. II. Frank Bures is a journalist. In 2001, he came across an unusual BBC article: a mob had killed twelve people in Nigeria, believing them to be penis-stealing witches. A few months later, a similar article: five people, Benin. He tried to pitch a story about the phenomenon to his editor, who “said he couldn’t pay me to fly to Nigeria and find essentially . . . nothing”. For some reason - and this is the point at which I start to worry about narrator reliability - Bures became obsessed with this. He couldn’t get it out of his mind. He started scraping together money to visit Africa on his own, story be damned: Nigeria gnawed at me. I knew that it was a terrible time to leave. I knew that [my wife] Bridgit, newly pregnant, wouldn’t want me to go. But I also knew that I had to, and that if I didn’t it would be a lifelong regret. . . three months later, I was the lone tourist on a plane full of Nigerians descending to Lagos. Africa is a relative newcomer to penis-stealing witches: The first recorded incident of penis theft in Africa I could find took place in Sudan in the 1960s. But in the mid- to late seventies in Nigeria, there were waves of well-documented cases. One of these happened in the northern city of Kaduna, where a psychiatrist named Dr. Sunday Ilechukwu was working in his office when a policeman arrived, escorting two men. One of them said he needed a medical assessment: He had accused the other of making his penis disappear. As with [a previously discussed incident], this had caused a disturbance in the street. During Ilechukwu’s examination, he later recounted, the victim stared straight ahead while the doctor examined his penis and pronounced him normal. “Exclaiming,” Ilechukwu wrote in the Transcultural Psychiatric Review, “the patient looked down at his groin for the first time, suggesting that the genitals had just reappeared.” According to Ilechukwu, this was part of an epidemic of magical penis theft that swept through Nigeria between 1975 and 1977. “Men could be seen in the streets of Lagos holding on to their genitalia either openly or discreetly with their hand in their pockets,” Ilechukwu wrote. “Women were also seen holding on to their breasts directly or discreetly, by crossing the hands across the chest . . . Vigilance and anticipatory aggression were thought to be good prophylaxes. This led to further breakdown of law and order.” During an incident, the victim would yell: “Thief! My genitals are gone!” Immediately, a culprit would be identified, apprehended by a crowd, and often killed. …but it’s been making up for lost time. Bures was able to find and interview one previous penis theft victim, plus the friend of another. Both described similar stories: someone had bumped up against them under weird circumstances, they immediately noticed their penis was much smaller than usual, they called out the culprit, and - apparently because the witch involved didn’t want to get in trouble - their penis was restored. Whatever weird itch this topic had given Bures, this didn’t satisfy him. He writes, very lucidly, about a desire to get closer to “the story”. He started bumping up against random Nigerians in suspicious ways, hoping one of them would accuse him of stealing their penis. Bures was an obvious foreigner, and a these panics often resulted in the suspected penis-stealer getting lynched, so this was a crazy thing to do. He could easily have died. Instead, everyone politely ignored him, nothing happened, and a slightly-disappointed Bures flew back to his poor family and abandoned his weird obsession. III. …for four years. After that the bug bit him again and he flew to Asia, long a center of penis-stealing witch activity. There are nature documentaries on lions, dolphins, even dinosaurs. They all share a common pattern: you talk about your subject’s habitat, their diet, their behaviors. The Asian half of The Geography Of Madness has the feel of a nature documentary on penis-stealing witches. And the last beat of every nature documentary has to be: this majestic creature, which once roamed from one end of the region to the other, is now endangered, threatened by increasing globalization and industrial activity. This is true for the witches also. Bures’ time in Hong Kong was a bust. There was a penis theft panic there forty years earlier, and he was able to interview some of the doctors who treated it. But they all said that was long ago. Now everybody is Westernized and has Western fears like vaccine injury or structural racism. They get Western mental disorders like depression and anorexia. The idea of witches stealing their penises seems as risible to them as it probably does to you. Singapore was also a bust. Bures had hoped it wouldn’t be, because it’s full of Malaysians, and Malaysia holds a special place in history as the spot where penis-stealing witches first made contact with Western science. The Malaysian word for the condition is koro (it means “head of a turtle”, based on an analogy to the penis retracting into the body the same way a turtle’s head retracts into its shell), and it is by this name that the condition gets listed in the DSM and the rest of the medical literature. Neither I nor Bures was able to find many ethnic Malays worrying about koro; most of the activity seems to be from Malaysian-Chinese. The Chinese definitely worry about it, attributing it to a wide variety of causes including poisoning, yin-yang imbalance, and - yes - witches. But Bures found nothing among any ethnicity. Once again, all the doctors said it used to be common, but disappeared as the city industrialized and adopted Western ways. Guangzhou was also a bust. The doctors said the same thing - in the old days, there would be huge epidemics of koro, social contagions that would impact hundreds of people at once. Now only a few superstitious rural people still believed. One traditional healer said he saw “three or four” cases a year. All the educated people had moved on. I once saw a nature documentary on Tasmanian tigers. Most people believe these have been extinct since 1930. Still, there are occasional unconfirmed sightings, especially in a remote area called Cape York, and every so often some scientists trudge off to Cape York with traps and cameras in the hopes of getting lucky. Bures decides end his own nature documentary with an expedition to the Cape York of the penis-stealing witches. This is a remote island village in China called Lin’gao, where in 1984: . . . rumors spread of a fox ghost - sometimes disguised an old woman roaming the land—collecting penises in covered baskets she carried on a shoulder pole. When two young men approached her and told her to uncover the baskets, they looked inside, saw that the baskets were filled with penises and died instantly of fright. Panic about koro would hit a village and last three to four days. When residents heard about a case in a neighboring village, the panic would subside, since that meant the ghost had moved on. The attacks slowly made their way around the island. The ghost struck at night, when villagers were sleeping. A chill would creep into the room, and suddenly the victim would feel his penis shrinking inward. He would grab it and run outside for help. A twenty-eight-year-old office worker was at home one night when: > “ . . . he heard a gong being beaten and the terrifying noises made by people who were panicking in a nearby neighborhood. He suddenly became anxious and experienced the sensation that his penis was shrinking. He was seized with panic and shouted loudly for help. Several men in the neighborhood rushed in and tried to rescue him by forcefully pulling his penis and making loud sounds to chase away the evil ghost that was thought to be affecting him.” Neighbors and family members were enlisted in rescue operations. Victims were beaten with sandals and slippers while the middle finger of their left had was squeezed, so that the ghost could exit the body there. The epidemic engulfed the island, with the exception of the Li and Miao minorities, who seemed to be immune to such fears. Researchers estimated that between 2,000 and 5,000 people were affected, but that “no one died from genital retraction.” One baby, however, did die when his mother tried to feed him pepper juice, and a girl was beaten to death during a two-hour exorcism. “Numerous men suffered injuries to their penises as a result of ‘rescuing’ actions.” Iron pins were sometimes inserted through the nipples of women to prevent retraction, which caused infections as well. This was, as far as anyone knows, the last great koro epidemic in Asia. Bures had a terrible time getting to Lin’gao. He had equal trouble getting an interpreter; the natives spoke a language called Be, very distantly related to Thai but not at all to regular Chinese. Finally he found someone who was able to contact a local shaman. Like any good doctor, the shaman referred him to a specialist - in this case, the designated anti-ghost shaman, who lived in a different village. He spent most of his time off on various ghost-fighting missions, but eventually Bures and his team were able to track him down. I want you to picture the scene. An American journalist has been traveling the world in search of a dying variety of witchcraft. Now he’s reached the end of the line, the wildest and most primitive region of China. With great difficulty, he has procured an interpreter. Together, they consult a shaman, who sends them on a quest to find a second, wiser shaman who specializes in ghosts. After many trials and tribulations, he reaches the second, wiser, ghost-specialist shaman, who invites him into his home, filled with strange charms and magical images. “Tell me your question,” says the shaman. And Bures asks: “What do you know about penis-stealing witches?” . . . and the shaman answers: “Haha, no one believes in that stuff anymore.” IV. So as a nature documentary, The Geography of Madness is kind of a bust. Still, Bures rescues it with some great analysis of culture-bound mental illness. A culture-bound mental illness is one that only affects people who know about it, and especially people who believe in it. Often it doesn’t make sense from a scientific point of view (there’s no such thing as witches, and the penis can’t retract into the body). It sometimes spreads contagiously: someone gets a first case, the rest of the village panics, and now everyone knows about it / believes in it / is thinking about it, and so many other people get it too. Different cultures have their own set of culture-bound illnesses. Sometimes there are commonalities - many cultures have something something penis something witches - but the details vary, and a victim almost always gets a case that matches the way their own culture understands it. THESE PEOPLE ARE NOT MAKING IT UP. I cannot stress this enough. There are plenty of examples of people driving metal objects through their penis in order to pull it out of their body or prevent the witches from getting it or something like that. There is no amount of commitment to the bit which will make people drive metal objects through their penis. People have died from these conditions - not the illness itself, which is fake, but from wasting away worrying about it, or taking dangerous sham treatments, or getting into fights with people they think caused it. If you think of it as “their unconscious mind must be doing something like making it up, but their conscious mind believes it 100%”, you will be closer to the truth, though there are various reasons I don’t like that framing. In Rajasthan, India, people come to the hospital with gilahari (lizard) syndrome. Patients say a lizard-like mass, sometimes visible as a skin swelling, is crawling around the body. They express terror that it will reach their airway and suffocate them. Japanese people may contract jikoshu-kyofu, a debilitating fear that they have terrible body odor. No amount of reassurances by friends and psychiatrists can convince these people that they smell normal, nor will any number of deodorants or perfumes make them comfortable. The French suffer from bouffée délirante, where a perfectly healthy person suddenly becomes completely psychotic, with well-formed hallucinations and delusions - then recovers just as suddenly, sometimes over hours or days. This is not how psychosis works anywhere except France and a few former French colonies. Traditional Chinese medicine monitors the balance between yin and yang. The male orgasm can deplete yang, and sure enough in China (but nowhere else) some men suffer traditional symptoms of yang depletion after they orgasm. “The symptoms can last weeks to months after a single orgasm, [and include] chills, dizziness, [and] backache”. The phrase “run amok” comes from Malaysia, where it referred to a specific phenomenon: some person who had been unhappy for a long time would suddenly snap, kill a bunch of people, then say they had no memory of doing it. Malaysian culture totally rolls with this and doesn’t hold it against them; the unhappiness is a risk factor for possession by a tiger spirit, which commits the killings. Although Malays have been doing this since at least the 1700s, there are some fascinating parallels with modern US mass shootings that suggest the damn tiger spirits have finally made it to the US common psychological origins. I have seen exactly one demonic possession case in my ten years as a psychiatrist. The man fell to the ground, mouth foaming, chanting strange syllables and the names of Biblical demons. My attending doctor at the time - one of those people who somehow manages to be an expert in everything - was an expert in demonic possession, and told us that he was in no way psychotic, antipsychotics wouldn’t help him (except insofar as they help everyone by decreasing all behaviors), and he needed to “work through his issues”. The patient was uncooperative - he was only visiting MDs because the local bishop wouldn’t call in an exorcist until he got a psych exam - and eventually left against medical advice. After going down the list, Bures asks the correct next question: how do we know whether or not our own mental illnesses are just as culture-bound as the Japanese or Malaysians’? Cultures that believe in witches have witch-related culture-bound illnesses; cultures that believe in demons have demon-related ones. We believe in science, so we should expect sciencey-sounding culture-bound illnesses, and these might be hard to tell apart from other, more physical conditions. So how suspicious should we be, and of what? Certainly we have some culture-bound mental illnesses. Electromagnetic hypersensitivity is a condition where some people supposedly become very sick when exposed to electromagnetic fields (like from cell phones). This sounds very scientific and makes perfect sense according to our culture, but researchers have found that placebo electrical devices make them exactly as sick as real ones, and that devices they don’t know about don’t make them sick at all. These people’s pain is real, and their lives are very difficult (although a few have found refuge in the National Radio Quiet Zone, an area in Virginia where the government enforces a ban on electromagnetic transmissions for secret military reasons). But their condition only afflicts them because they believe in it, much like with koro. Fine, everyone knows that one’s not real. What about DSM-style mental disorders, the stuff everyone’s supposed to believe in? Are those culture-bound? Unfortunately, I think Bures kind of flubs this section. He decides to focus on PMS (premenstrual syndrome), which is officially included in the DSM as PMDD (premenstrual dysphoric disorder). After discussing the history of hysteria, he writes that: Today, hysteria is never diagnosed, except by unwise husbands. In 1931, however, an American gynecologist named Robert Frank revived the idea in a new guise. He published an article titled, “The hormonal causes of premenstrual tension.” Frank described symptoms that occurred in the week before menstruation: irritability, bloating, fatigue, depression, attacks of pain, nervousness, restlessness, and the impulse for “foolish and ill considered actions,” due to ovarian activity. Again, the cause was the uterus. Then in 1953, British physician Katharina Dalton elaborated on this, arguing the condition came from fluctuation of estrogen and progesterone. She called it Premenstrual Syndrome, and soon symptoms grew to include: anxiety, sadness, moodiness, constipation or diarrhea, feeling out of control, insomnia, food cravings, increased sex drive, anger, arguments with family or friends, poor judgment, lack of physical coordination, decreased efficiency, increased personal strength or power, feelings of connection to nature or to other women, seizures, convulsions, asthma attacks, not to mention flare ups in asthma, allergies, sinusitis, anxiety disorders, irritable bowel syndrome, migraines, and multiple sclerosis. If any of these symptoms occurred in the second half of the menstrual cycle, one had PMS. Estimates of the number of women afflicted ranged from 5 percent to 95 percent. In the 1980s, three women in the UK were tried for arson, assault and manslaughter. The three all claimed they had diminished responsibility due to PMS, and got reduced sentences on the condition that they underwent hormone treatment. After that, according to one study, American women flooded doctors with requests for help with their PMS. “Popular groups like PMS Action were founded to promote recognition and treatment of PMS by medical professionals. Private PMS clinics began to appear in the USA, modeled after those in the UK, and progesterone therapy was enthusiastically adopted, much to the chagrin of many gynaecologists who viewed its use as ‘unscientific’ and ‘commercial’, not to mention unlicensed." Based on all this, the 1987 version of the DSM-III included a new category: Late Luteal Phase Disorder (luteal refers to progesterone). It was proposed as a topic for further research, but despite the absence of such research, it was included in the 1994 edition of the DSM-IV under the name Premenstrual Dysmorphic Disorder, or PMDD.96 In 2013, in the DSM-5, it was given its own category as a full-fledged mental illness. Yet neither PMS nor PMDD occur in most cultures. There are no biomarkers to measure them by. No conclusive correlation has ever been found between estrogen or progesterone levels and PMS. As one study noted, “the more time that women of ethnic minorities spend living in the United States, the more likely they are to report PMDD. Thus, if we are to accept PMDD as a reified medical disorder, then we must also accept exposure to U.S. culture as a risk factor for contracting PMDD.” If it is a syndrome at all, it’s a cultural one. I asked my wife what she thought of this, and she told me: The day before her first-ever period, as a teenager, when she had never really thought about PMS, she felt exceptionally weird, emotional, and generally off, to the point where it seemed to demand an explanation. Then she had her first-ever period, and retroactively explains it as PMS.
Inline links: source, my review of the, Geography Of Madness, Be, gilahari (lizard) syndrome, jikoshu-kyofu, bouffée délirante, suffer traditional symptoms of yang depletion, run amok, Electromagnetic hypersensitivity, National Radio Quiet Zone
premenstrual dysphoric disorder1 mentions across 1 issues

premenstrual dysphoric disorder is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between February 14, 2023 and February 14, 2023. The archive places it in contexts such as "a restatement of some of the arguments I made in Cowpox Of Doubt. A few days ago, I had to form an opinion on whether premenstrual dysphoric disorder was culture-bound or not". It most often appears alongside Atala, Atlantis, Atzlan.

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1
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February 14, 2023
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February 14, 2023
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Contra Kavanagh On Fideism
February 14, 2023 · Original source
A few days ago, I had to form an opinion on whether premenstrual dysphoric disorder was culture-bound or not (if that sentence doesn’t make sense to you, don’t worry - you can replace it with “whether skub is good or not” and lose nothing).
Premenstrual Syndrome1 mentions across 1 issues

Premenstrual Syndrome is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between February 22, 2023 and February 22, 2023. The archive places it in contexts such as "She called it Premenstrual Syndrome". It most often appears alongside Africa, Agin, American.

Reference entry
Premenstrual Syndrome
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1
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1
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February 22, 2023
Last seen
February 22, 2023
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Book Review: The Geography Of Madness
February 22, 2023 · Original source
This image (source) of a witch stealing a man’s penis, with a box of previously-stolen penises to her right accompanies the 1411 poem “Flowers Of Virtue” in its 1486 edition. Malleus Maleficarum was published in 1486, so if the original text of Flowers Of Virtue contained the incident this picture refers to, it would predate Malleus. But the original text is written in poetic medieval German and I can’t find a good translation. When I wrote my review of the Malleus, people were surprised at the penis-stealing witch chapters. Yet nothing could possibly be less surprising; the penis-stealing witches are timeless and omnipresent. When commenters continued to doubt, I promised them this review of Frank Bures’ Geography Of Madness. II. Frank Bures is a journalist. In 2001, he came across an unusual BBC article: a mob had killed twelve people in Nigeria, believing them to be penis-stealing witches. A few months later, a similar article: five people, Benin. He tried to pitch a story about the phenomenon to his editor, who “said he couldn’t pay me to fly to Nigeria and find essentially . . . nothing”. For some reason - and this is the point at which I start to worry about narrator reliability - Bures became obsessed with this. He couldn’t get it out of his mind. He started scraping together money to visit Africa on his own, story be damned: Nigeria gnawed at me. I knew that it was a terrible time to leave. I knew that [my wife] Bridgit, newly pregnant, wouldn’t want me to go. But I also knew that I had to, and that if I didn’t it would be a lifelong regret. . . three months later, I was the lone tourist on a plane full of Nigerians descending to Lagos. Africa is a relative newcomer to penis-stealing witches: The first recorded incident of penis theft in Africa I could find took place in Sudan in the 1960s. But in the mid- to late seventies in Nigeria, there were waves of well-documented cases. One of these happened in the northern city of Kaduna, where a psychiatrist named Dr. Sunday Ilechukwu was working in his office when a policeman arrived, escorting two men. One of them said he needed a medical assessment: He had accused the other of making his penis disappear. As with [a previously discussed incident], this had caused a disturbance in the street. During Ilechukwu’s examination, he later recounted, the victim stared straight ahead while the doctor examined his penis and pronounced him normal. “Exclaiming,” Ilechukwu wrote in the Transcultural Psychiatric Review, “the patient looked down at his groin for the first time, suggesting that the genitals had just reappeared.” According to Ilechukwu, this was part of an epidemic of magical penis theft that swept through Nigeria between 1975 and 1977. “Men could be seen in the streets of Lagos holding on to their genitalia either openly or discreetly with their hand in their pockets,” Ilechukwu wrote. “Women were also seen holding on to their breasts directly or discreetly, by crossing the hands across the chest . . . Vigilance and anticipatory aggression were thought to be good prophylaxes. This led to further breakdown of law and order.” During an incident, the victim would yell: “Thief! My genitals are gone!” Immediately, a culprit would be identified, apprehended by a crowd, and often killed. …but it’s been making up for lost time. Bures was able to find and interview one previous penis theft victim, plus the friend of another. Both described similar stories: someone had bumped up against them under weird circumstances, they immediately noticed their penis was much smaller than usual, they called out the culprit, and - apparently because the witch involved didn’t want to get in trouble - their penis was restored. Whatever weird itch this topic had given Bures, this didn’t satisfy him. He writes, very lucidly, about a desire to get closer to “the story”. He started bumping up against random Nigerians in suspicious ways, hoping one of them would accuse him of stealing their penis. Bures was an obvious foreigner, and a these panics often resulted in the suspected penis-stealer getting lynched, so this was a crazy thing to do. He could easily have died. Instead, everyone politely ignored him, nothing happened, and a slightly-disappointed Bures flew back to his poor family and abandoned his weird obsession. III. …for four years. After that the bug bit him again and he flew to Asia, long a center of penis-stealing witch activity. There are nature documentaries on lions, dolphins, even dinosaurs. They all share a common pattern: you talk about your subject’s habitat, their diet, their behaviors. The Asian half of The Geography Of Madness has the feel of a nature documentary on penis-stealing witches. And the last beat of every nature documentary has to be: this majestic creature, which once roamed from one end of the region to the other, is now endangered, threatened by increasing globalization and industrial activity. This is true for the witches also. Bures’ time in Hong Kong was a bust. There was a penis theft panic there forty years earlier, and he was able to interview some of the doctors who treated it. But they all said that was long ago. Now everybody is Westernized and has Western fears like vaccine injury or structural racism. They get Western mental disorders like depression and anorexia. The idea of witches stealing their penises seems as risible to them as it probably does to you. Singapore was also a bust. Bures had hoped it wouldn’t be, because it’s full of Malaysians, and Malaysia holds a special place in history as the spot where penis-stealing witches first made contact with Western science. The Malaysian word for the condition is koro (it means “head of a turtle”, based on an analogy to the penis retracting into the body the same way a turtle’s head retracts into its shell), and it is by this name that the condition gets listed in the DSM and the rest of the medical literature. Neither I nor Bures was able to find many ethnic Malays worrying about koro; most of the activity seems to be from Malaysian-Chinese. The Chinese definitely worry about it, attributing it to a wide variety of causes including poisoning, yin-yang imbalance, and - yes - witches. But Bures found nothing among any ethnicity. Once again, all the doctors said it used to be common, but disappeared as the city industrialized and adopted Western ways. Guangzhou was also a bust. The doctors said the same thing - in the old days, there would be huge epidemics of koro, social contagions that would impact hundreds of people at once. Now only a few superstitious rural people still believed. One traditional healer said he saw “three or four” cases a year. All the educated people had moved on. I once saw a nature documentary on Tasmanian tigers. Most people believe these have been extinct since 1930. Still, there are occasional unconfirmed sightings, especially in a remote area called Cape York, and every so often some scientists trudge off to Cape York with traps and cameras in the hopes of getting lucky. Bures decides end his own nature documentary with an expedition to the Cape York of the penis-stealing witches. This is a remote island village in China called Lin’gao, where in 1984: . . . rumors spread of a fox ghost - sometimes disguised an old woman roaming the land—collecting penises in covered baskets she carried on a shoulder pole. When two young men approached her and told her to uncover the baskets, they looked inside, saw that the baskets were filled with penises and died instantly of fright. Panic about koro would hit a village and last three to four days. When residents heard about a case in a neighboring village, the panic would subside, since that meant the ghost had moved on. The attacks slowly made their way around the island. The ghost struck at night, when villagers were sleeping. A chill would creep into the room, and suddenly the victim would feel his penis shrinking inward. He would grab it and run outside for help. A twenty-eight-year-old office worker was at home one night when: > “ . . . he heard a gong being beaten and the terrifying noises made by people who were panicking in a nearby neighborhood. He suddenly became anxious and experienced the sensation that his penis was shrinking. He was seized with panic and shouted loudly for help. Several men in the neighborhood rushed in and tried to rescue him by forcefully pulling his penis and making loud sounds to chase away the evil ghost that was thought to be affecting him.” Neighbors and family members were enlisted in rescue operations. Victims were beaten with sandals and slippers while the middle finger of their left had was squeezed, so that the ghost could exit the body there. The epidemic engulfed the island, with the exception of the Li and Miao minorities, who seemed to be immune to such fears. Researchers estimated that between 2,000 and 5,000 people were affected, but that “no one died from genital retraction.” One baby, however, did die when his mother tried to feed him pepper juice, and a girl was beaten to death during a two-hour exorcism. “Numerous men suffered injuries to their penises as a result of ‘rescuing’ actions.” Iron pins were sometimes inserted through the nipples of women to prevent retraction, which caused infections as well. This was, as far as anyone knows, the last great koro epidemic in Asia. Bures had a terrible time getting to Lin’gao. He had equal trouble getting an interpreter; the natives spoke a language called Be, very distantly related to Thai but not at all to regular Chinese. Finally he found someone who was able to contact a local shaman. Like any good doctor, the shaman referred him to a specialist - in this case, the designated anti-ghost shaman, who lived in a different village. He spent most of his time off on various ghost-fighting missions, but eventually Bures and his team were able to track him down. I want you to picture the scene. An American journalist has been traveling the world in search of a dying variety of witchcraft. Now he’s reached the end of the line, the wildest and most primitive region of China. With great difficulty, he has procured an interpreter. Together, they consult a shaman, who sends them on a quest to find a second, wiser shaman who specializes in ghosts. After many trials and tribulations, he reaches the second, wiser, ghost-specialist shaman, who invites him into his home, filled with strange charms and magical images. “Tell me your question,” says the shaman. And Bures asks: “What do you know about penis-stealing witches?” . . . and the shaman answers: “Haha, no one believes in that stuff anymore.” IV. So as a nature documentary, The Geography of Madness is kind of a bust. Still, Bures rescues it with some great analysis of culture-bound mental illness. A culture-bound mental illness is one that only affects people who know about it, and especially people who believe in it. Often it doesn’t make sense from a scientific point of view (there’s no such thing as witches, and the penis can’t retract into the body). It sometimes spreads contagiously: someone gets a first case, the rest of the village panics, and now everyone knows about it / believes in it / is thinking about it, and so many other people get it too. Different cultures have their own set of culture-bound illnesses. Sometimes there are commonalities - many cultures have something something penis something witches - but the details vary, and a victim almost always gets a case that matches the way their own culture understands it. THESE PEOPLE ARE NOT MAKING IT UP. I cannot stress this enough. There are plenty of examples of people driving metal objects through their penis in order to pull it out of their body or prevent the witches from getting it or something like that. There is no amount of commitment to the bit which will make people drive metal objects through their penis. People have died from these conditions - not the illness itself, which is fake, but from wasting away worrying about it, or taking dangerous sham treatments, or getting into fights with people they think caused it. If you think of it as “their unconscious mind must be doing something like making it up, but their conscious mind believes it 100%”, you will be closer to the truth, though there are various reasons I don’t like that framing. In Rajasthan, India, people come to the hospital with gilahari (lizard) syndrome. Patients say a lizard-like mass, sometimes visible as a skin swelling, is crawling around the body. They express terror that it will reach their airway and suffocate them. Japanese people may contract jikoshu-kyofu, a debilitating fear that they have terrible body odor. No amount of reassurances by friends and psychiatrists can convince these people that they smell normal, nor will any number of deodorants or perfumes make them comfortable. The French suffer from bouffée délirante, where a perfectly healthy person suddenly becomes completely psychotic, with well-formed hallucinations and delusions - then recovers just as suddenly, sometimes over hours or days. This is not how psychosis works anywhere except France and a few former French colonies. Traditional Chinese medicine monitors the balance between yin and yang. The male orgasm can deplete yang, and sure enough in China (but nowhere else) some men suffer traditional symptoms of yang depletion after they orgasm. “The symptoms can last weeks to months after a single orgasm, [and include] chills, dizziness, [and] backache”. The phrase “run amok” comes from Malaysia, where it referred to a specific phenomenon: some person who had been unhappy for a long time would suddenly snap, kill a bunch of people, then say they had no memory of doing it. Malaysian culture totally rolls with this and doesn’t hold it against them; the unhappiness is a risk factor for possession by a tiger spirit, which commits the killings. Although Malays have been doing this since at least the 1700s, there are some fascinating parallels with modern US mass shootings that suggest the damn tiger spirits have finally made it to the US common psychological origins. I have seen exactly one demonic possession case in my ten years as a psychiatrist. The man fell to the ground, mouth foaming, chanting strange syllables and the names of Biblical demons. My attending doctor at the time - one of those people who somehow manages to be an expert in everything - was an expert in demonic possession, and told us that he was in no way psychotic, antipsychotics wouldn’t help him (except insofar as they help everyone by decreasing all behaviors), and he needed to “work through his issues”. The patient was uncooperative - he was only visiting MDs because the local bishop wouldn’t call in an exorcist until he got a psych exam - and eventually left against medical advice. After going down the list, Bures asks the correct next question: how do we know whether or not our own mental illnesses are just as culture-bound as the Japanese or Malaysians’? Cultures that believe in witches have witch-related culture-bound illnesses; cultures that believe in demons have demon-related ones. We believe in science, so we should expect sciencey-sounding culture-bound illnesses, and these might be hard to tell apart from other, more physical conditions. So how suspicious should we be, and of what? Certainly we have some culture-bound mental illnesses. Electromagnetic hypersensitivity is a condition where some people supposedly become very sick when exposed to electromagnetic fields (like from cell phones). This sounds very scientific and makes perfect sense according to our culture, but researchers have found that placebo electrical devices make them exactly as sick as real ones, and that devices they don’t know about don’t make them sick at all. These people’s pain is real, and their lives are very difficult (although a few have found refuge in the National Radio Quiet Zone, an area in Virginia where the government enforces a ban on electromagnetic transmissions for secret military reasons). But their condition only afflicts them because they believe in it, much like with koro. Fine, everyone knows that one’s not real. What about DSM-style mental disorders, the stuff everyone’s supposed to believe in? Are those culture-bound? Unfortunately, I think Bures kind of flubs this section. He decides to focus on PMS (premenstrual syndrome), which is officially included in the DSM as PMDD (premenstrual dysphoric disorder). After discussing the history of hysteria, he writes that: Today, hysteria is never diagnosed, except by unwise husbands. In 1931, however, an American gynecologist named Robert Frank revived the idea in a new guise. He published an article titled, “The hormonal causes of premenstrual tension.” Frank described symptoms that occurred in the week before menstruation: irritability, bloating, fatigue, depression, attacks of pain, nervousness, restlessness, and the impulse for “foolish and ill considered actions,” due to ovarian activity. Again, the cause was the uterus. Then in 1953, British physician Katharina Dalton elaborated on this, arguing the condition came from fluctuation of estrogen and progesterone. She called it Premenstrual Syndrome, and soon symptoms grew to include: anxiety, sadness, moodiness, constipation or diarrhea, feeling out of control, insomnia, food cravings, increased sex drive, anger, arguments with family or friends, poor judgment, lack of physical coordination, decreased efficiency, increased personal strength or power, feelings of connection to nature or to other women, seizures, convulsions, asthma attacks, not to mention flare ups in asthma, allergies, sinusitis, anxiety disorders, irritable bowel syndrome, migraines, and multiple sclerosis. If any of these symptoms occurred in the second half of the menstrual cycle, one had PMS. Estimates of the number of women afflicted ranged from 5 percent to 95 percent. In the 1980s, three women in the UK were tried for arson, assault and manslaughter. The three all claimed they had diminished responsibility due to PMS, and got reduced sentences on the condition that they underwent hormone treatment. After that, according to one study, American women flooded doctors with requests for help with their PMS. “Popular groups like PMS Action were founded to promote recognition and treatment of PMS by medical professionals. Private PMS clinics began to appear in the USA, modeled after those in the UK, and progesterone therapy was enthusiastically adopted, much to the chagrin of many gynaecologists who viewed its use as ‘unscientific’ and ‘commercial’, not to mention unlicensed." Based on all this, the 1987 version of the DSM-III included a new category: Late Luteal Phase Disorder (luteal refers to progesterone). It was proposed as a topic for further research, but despite the absence of such research, it was included in the 1994 edition of the DSM-IV under the name Premenstrual Dysmorphic Disorder, or PMDD.96 In 2013, in the DSM-5, it was given its own category as a full-fledged mental illness. Yet neither PMS nor PMDD occur in most cultures. There are no biomarkers to measure them by. No conclusive correlation has ever been found between estrogen or progesterone levels and PMS. As one study noted, “the more time that women of ethnic minorities spend living in the United States, the more likely they are to report PMDD. Thus, if we are to accept PMDD as a reified medical disorder, then we must also accept exposure to U.S. culture as a risk factor for contracting PMDD.” If it is a syndrome at all, it’s a cultural one. I asked my wife what she thought of this, and she told me: The day before her first-ever period, as a teenager, when she had never really thought about PMS, she felt exceptionally weird, emotional, and generally off, to the point where it seemed to demand an explanation. Then she had her first-ever period, and retroactively explains it as PMS.
Inline links: source, my review of the, Geography Of Madness, Be, gilahari (lizard) syndrome, jikoshu-kyofu, bouffée délirante, suffer traditional symptoms of yang depletion, run amok, Electromagnetic hypersensitivity, National Radio Quiet Zone
presbyters1 mentions across 1 issues

presbyters is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between November 12, 2024 and November 12, 2024. The archive places it in contexts such as "a number of presbyters, deacons, and laymen winning high commendation". It most often appears alongside 1 Peter 3, 165 AD, 1990s.

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presbyters
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1
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1
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November 12, 2024
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November 12, 2024
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Book Review: The Rise Of Christianity
November 12, 2024 · Original source
…and 5 “really serious” famines …for an average of one catastrophe per fifteen years. The Romans rebuilt the city each time because it was strategically important. Stark focuses on one of these disasters: plague. The Roman Empire suffered two major plagues during this era: the Antonine Plague of 165 AD and the Cyprian Plague of 251 AD . He theorizes that Christians made it through these plagues much better than pagans, gaining an additional population boost. Time for some game theory: when a plague comes, you can either defect (flee / self-isolate / hide) or cooperate (altruistically try to help nurse other victims). An individual does better by defecting, but a community does better if all its members cooperate. Stark thinks the pagans defected and the Christians cooperated. Here is Thucydides’ description of a plague in pagan Athens (admittedly ~500 years before the time we’re studying). People quickly got an instinctive proto-knowledge of how contagion worked, after which: [People] died with no one to look after them; indeed there were many houses in which all the inhabitants perished through lack of any attention…the bodies of the dying were heaped one on top of the other, and half-dead creatures could be seen staggering about in the streets or flocking around the fountains in their desire for water. The temples in which they took up their quarters were full of the dead bodies of people who had died inside them. For the catastrophe was so overwhelming that men, not knowing what would happen next to them, became indifferent to every rule of religion or law. Compare the Christian writer Dionysius’s description of a plague afflicting his own community: Most of our brother Christians showed unbounded love and loyalty, never sparing themselves and thinking only of one another. Heedless of danger, they took charge of the sick, attending to their every need and ministering to them in Christ, and with them departed this life serenely happy, for they were infected by others with the disease, drawing on themselves the sickness of their neighbors and cheerfully accepting their pains. Many, in nursing and curing others, transferred their death to themselves and died in their stead. The best of our brothers lost their lives in this manner, a number of presbyters, deacons, and laymen winning high commendation so that death in this form, the result of great piety and strong faith, seems in every way the equal of martyrdom […] The heathen behaved in the very opposite way. At the first onset of the disease, they pushed the sufferers away and fled from their dearest, throwing them in the roads before they were dead and treated unburied corpses as dirt, hoping thereby to avert the spread and contagion of the fatal disease. Could Dionysius be embellishing matters to make his friends look good and his enemies bad? Maybe, but: There was compelling evidence from pagan sources that this was characteristic Christian behavior. Thus, a century later, the emperor Julian launched a campaign to institute pagan charities in an effort to match the Christians. Julian complained in a letter to the high priest of Galatia in 362 that the pagans needed to equal the virtues of Christians, for recent Christian growth was caused by their “moral character, even if pretended,” and by their “benevolence toward strangers and care for the graves of the dead”. In a letter to another priest, Julian wrote, “I think that when the poor happened to be neglected and overlooked by the priests, the impious Galileans observed this and devoted themselves to benevolence.” And he also wrote, “The impious Galileans support not only their poor, but ours as well, everyone can see that our people lack aid from us.” Did this matter? It might have! “Modern medical experts believe that conscientious nursing without any medications could cut the mortality rate by 2/3 or even more.” (if this sounds implausible, keep in mind that “nursing” here includes things like “bringing water from the public well to bedridden people who are too weak to go out and get it themselves”.) Stark believes that plagues helped the Christians in multiple ways: The obvious way: 30% of pagans died during the plague, but only 10% of Christians, making Christians proportionally more of the population.
prescient1 mentions across 1 issues

prescient is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between August 13, 2022 and August 13, 2022. The archive places it in contexts such as "between her prescience and his rock-climbing skills". It most often appears alongside ACX, AI, ancient Greeks.

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prescient
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1
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1
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August 13, 2022
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August 13, 2022
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Your Book Review: God Emperor Of Dune
August 13, 2022 · Original source
Duncan’s recently bruised ego makes him easy to recruit to her cause, and between her prescience and his rock-climbing skills (read the book, it’s weird) they manage to do the impossible, assassinating the god-emperor and shattering his 3500-year-rule. He passes over control of his spice-hoard to them, and they proceed to have a thousand children to seed the universe with a strain of human immune to prescient search.
presenilin 11 mentions across 1 issues

presenilin 1 is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between August 14, 2025 and August 14, 2025. The archive places it in contexts such as "presenilin 1 and 2 and APP mutations linked to familial Alzheimer’s disease". It most often appears alongside A. Bejanin, A. de Calignon, A. Elobeid.

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presenilin 1
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1
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1
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August 14, 2025
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August 14, 2025
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In Defense Of The Amyloid Hypothesis
August 14, 2025 · Original source
[94] D. Scheuner et al., “Secreted amyloid β–protein similar to that in the senile plaques of Alzheimer’s disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer’s disease,” Nature Medicine, vol. 2, no. 8, pp. 864–870, Aug. 1996, doi: 10.1038/nm0896-864.
Inline links: 10.1038/nm0896-864
presenilin 21 mentions across 1 issues

presenilin 2 is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between August 14, 2025 and August 14, 2025. The archive places it in contexts such as "presenilin 1 and 2 and APP mutations linked to familial Alzheimer’s disease". It most often appears alongside A. Bejanin, A. de Calignon, A. Elobeid.

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presenilin 2
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1
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1
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August 14, 2025
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August 14, 2025
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In Defense Of The Amyloid Hypothesis
August 14, 2025 · Original source
[94] D. Scheuner et al., “Secreted amyloid β–protein similar to that in the senile plaques of Alzheimer’s disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer’s disease,” Nature Medicine, vol. 2, no. 8, pp. 864–870, Aug. 1996, doi: 10.1038/nm0896-864.
Inline links: 10.1038/nm0896-864
preservation by destruction1 mentions across 1 issues

preservation by destruction is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between April 30, 2021 and April 30, 2021. The archive places it in contexts such as "Thus sprang into action the ominously named “preservation by destruction”". It most often appears alongside 1893, 1970s, 1980s.

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1
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1
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April 30, 2021
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April 30, 2021
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Your Book Review: Double Fold
April 30, 2021 · Original source
Thus sprang into action the ominously named “preservation by destruction” (a phrase actually used by its proponents, not my or Baker’s invention). Baker likes to point out the Orwellian way in which modern-day book destroyers hijacked the very language of book salvaging. The microfilm departments in libraries were named “Preservation Departments,” in the vein of “Ministry of Peace” and “Ministry of Love.” Of course, the public was mostly unaware that the primary task of a Preservation Department is to cut up books and trash them afterwards. Inside the library, there often arose tensions between the people working in conservation departments, whose job was to carefully restore old books, and those in “preservation” departments, whose job was to destroy them. Baker speaks with an employee in a book conservation department, who recalls that the microfilmers were often referred to unflatteringly as “thugs” – in return, the book restorers got themselves the nickname “pansies.”
Preservation Departments1 mentions across 1 issues

Preservation Departments is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between April 30, 2021 and April 30, 2021. The archive places it in contexts such as "The microfilm departments in libraries were named “Preservation Departments,”". It most often appears alongside 1893, 1970s, 1980s.

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1
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1
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April 30, 2021
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April 30, 2021
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Your Book Review: Double Fold
April 30, 2021 · Original source
Thus sprang into action the ominously named “preservation by destruction” (a phrase actually used by its proponents, not my or Baker’s invention). Baker likes to point out the Orwellian way in which modern-day book destroyers hijacked the very language of book salvaging. The microfilm departments in libraries were named “Preservation Departments,” in the vein of “Ministry of Peace” and “Ministry of Love.” Of course, the public was mostly unaware that the primary task of a Preservation Department is to cut up books and trash them afterwards. Inside the library, there often arose tensions between the people working in conservation departments, whose job was to carefully restore old books, and those in “preservation” departments, whose job was to destroy them. Baker speaks with an employee in a book conservation department, who recalls that the microfilmers were often referred to unflatteringly as “thugs” – in return, the book restorers got themselves the nickname “pansies.”
preservation movement1 mentions across 1 issues

preservation movement is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between October 04, 2021 and October 04, 2021. The archive places it in contexts such as "the preservation movement followed close on the heels of widespread modernist building". It most often appears alongside 19th century African art, 20th century, 9-11.

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preservation movement
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1
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1
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October 04, 2021
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October 04, 2021
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Highlights From The Comments On Modern Architecture
October 04, 2021 · Original source
Note that the preservation movement followed close on the heels of widespread modernist building. It's quite possible that modernist architecture has had an enormous, though indirect, negative economic impact on middle class Americans by driving land use restrictions that make housing more expensive.
Presidency1 mentions across 1 issues

Presidency is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between September 17, 2024 and September 17, 2024. The archive places it in contexts such as "but not a Presidency contract". It most often appears alongside AI, Area 51, bird flu epidemic.

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Presidency
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1
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1
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September 17, 2024
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September 17, 2024
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  • 24 September 17, 2024
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24
September 17, 2024 · Original source
3: Kalshi vs. CFTC, round one million: after CFTC banned Kalshi from hosting political contracts last year, Kalshi appealed. Earlier this month, the judge sided with Kalshi, saying that the CFTC’s attempt to define elections as “gaming” so it can regulate them under anti-gaming laws is an illegal power grab. The judge claims this has no relevance to the CFTC’s broader anti-political-market push, but since the whole thing is based on the elections = gaming theory I think it has a lot of relevance indeed. The CFTC has since appealed, and Kalshi is blocked from hosting the contracts until the appeal goes through (it’s 49 days until the election; at this point even a pro-Kalshi ruling might be a Pyrrhic victory). Also, why is Kalshi trying to get Congress contracts up, but not a Presidency contract? More sympathetic test case?
Inline links: Earlier this month, sided with Kalshi
President1 mentions across 1 issues

President is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between November 09, 2021 and November 09, 2021. The archive places it in contexts such as "I don’t run for President, partly because I rationally conclude I won’t win". It most often appears alongside Aage Bohr, Abanindranath Tagore, Aldous Huxley.

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President
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1
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1
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November 09, 2021
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November 09, 2021
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Secrets Of The Great Families
November 09, 2021 · Original source
Aldous Huxley was an author most famous for Brave New World, though his other work is also great and underappreciated. His brother Julian Huxley founded UNESCO and the World Wildlife Fund and coined the terms "ethnic group", "cline", and "transhumanism". Their half-brother Andrew Huxley won the Nobel Prize in Medicine for discovering how nerves work. Their grandfather was Thomas Huxley, one of the first and greatest advocates of evolution, and President of the Royal Society.
Inline links: Aldous Huxley, Julian Huxley, Andrew Huxley, Thomas Huxley
Henri Poincare was a great mathematician, credited with pioneering chaos theory and topology. The Poincare Institute, Poincare Prize, and the Poincare Crater on the moon are all named after him. His cousin, Raymond Poincare, was president of France from 1913 to 1920. Raymond's brother, Lucien Poincare, was a distinguished physicist, and head of the University of Paris.
Inline links: Henri Poincare, Raymond Poincare
Charles Darwin discovered the theory of evolution. His grandfather Erasmus Darwin also groped towards some kind of proto-evolutionary theory, made contributions in botany and pathology, and founded the influential Lunar Society of scientists. His other grandfather Josiah Wedgwood was a pottery tycoon who "pioneered direct mail, money back guarantees, self-service, free delivery, buy one get one free, and illustrated catalogues" and became "one of the wealthiest entrepreneurs of the 18th century". Charles' cousin Francis Galton invented the modern fields of psychometrics, meteorology, eugenics, and statistics (including standard deviation, correlation, and regression). Charles' son Sir George Darwin, an astronomer, became president of the Royal Astronomical Society and another Royal Society fellow. Charles' other son Leonard Darwin, became a major in the army, a Member of Parliament, President of the Royal Geography Society, and a mentor and patron to Ronald Fisher, another pioneer of modern statistics. Charles' grandson Charles Galton Darwin invented the Darwin-Fowler method in statistics, the Darwin Curve in diffraction physics, Darwin drift in fluid dynamics, and was the director of the UK's National Physical Laboratory (and vaguely involved in the Manhattan Project).
Inline links: Charles Darwin, Erasmus Darwin, Josiah Wedgwood, Francis Galton, Sir George Darwin, Leonard Darwin, Charles Galton Darwin
presidential Order of Merit1 mentions across 1 issues

presidential Order of Merit is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between April 12, 2023 and April 12, 2023. The archive places it in contexts such as "Shannon received the Presidential Order of Merit". It most often appears alongside AAAS, AIDS, American Academy of Arts and Sciences.

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April 12, 2023
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April 12, 2023
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Book Review: From Oversight To Overkill
April 12, 2023 · Original source
At a time when clerks and farm boys were being drafted and shipped to the Pacific, infecting the mentally ill with malaria was generally seen as asking no greater sacrifice of them than of everyone else. Nobody complained, major strides were made in the treatment of malaria, and Shannon received the Presidential Order of Merit.
Pretendians1 mentions across 1 issues

Pretendians is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between March 07, 2024 and March 07, 2024. The archive places it in contexts such as "brought the issue of fake Indians ("Pretendians") into the spotlight". It most often appears alongside 23andme, Adeline Rivers, Ancestry.com.

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Pretendians
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1
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1
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March 07, 2024
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March 07, 2024
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How Should We Think About Race And "Lived Experience"?
March 07, 2024 · Original source
After Elizabeth Warren and other high-profile cases brought the issue of fake Indians ("Pretendians") into the spotlight, some people from the Native community started going after Professor Hoover, challenging her to prove her Native descent. Over time the challenges got louder and louder, and eventually she had to admit she wasn’t Native after all. Some of her students wrote an open letter demanding that she resign, which said:
preventing child abuse1 mentions across 1 issues

preventing child abuse is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between February 23, 2024 and February 23, 2024. The archive places it in contexts such as "We call these ... “preventing child abuse”". It most often appears alongside Alabama, anti-abortion, IVF.

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preventing child abuse
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1
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1
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February 23, 2024
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February 23, 2024
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Who Does Polygenic Selection Help?
February 23, 2024 · Original source
And if the anti-abortionist doesn’t have much of a case here, pro-choice people have even less of a case. This is a non-injury to something they don’t even acknowledge as having rights anyway. It maps to cases where everyone agrees a good thing has been done, like asking pregnant women not to drink, or teaching high-risk men parenting skills. We call these “preventing fetal alcohol syndrome” and “preventing child abuse”, and it’s equally fair to call polygenic selection “preventing schizophrenia”.
preventing fetal alcohol syndrome1 mentions across 1 issues

preventing fetal alcohol syndrome is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between February 23, 2024 and February 23, 2024. The archive places it in contexts such as "We call these “preventing fetal alcohol syndrome”". It most often appears alongside Alabama, anti-abortion, IVF.

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February 23, 2024
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February 23, 2024
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Who Does Polygenic Selection Help?
February 23, 2024 · Original source
And if the anti-abortionist doesn’t have much of a case here, pro-choice people have even less of a case. This is a non-injury to something they don’t even acknowledge as having rights anyway. It maps to cases where everyone agrees a good thing has been done, like asking pregnant women not to drink, or teaching high-risk men parenting skills. We call these “preventing fetal alcohol syndrome” and “preventing child abuse”, and it’s equally fair to call polygenic selection “preventing schizophrenia”.
preventing schizophrenia1 mentions across 1 issues

preventing schizophrenia is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between February 23, 2024 and February 23, 2024. The archive places it in contexts such as "and it’s equally fair to call polygenic selection “preventing schizophrenia”". It most often appears alongside Alabama, anti-abortion, IVF.

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1
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1
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February 23, 2024
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February 23, 2024
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Who Does Polygenic Selection Help?
February 23, 2024 · Original source
Some commenters challenge my statement that this represents successfully preventing schizophrenia, at least in the same way that eg better prenatal nutrition prevents schizophrenia. They point out that it didn’t exactly prevent schizophrenia in any particular person, so much as replace a schizophrenic with a non-schizophrenic.
Inline links: commenters
And if the anti-abortionist doesn’t have much of a case here, pro-choice people have even less of a case. This is a non-injury to something they don’t even acknowledge as having rights anyway. It maps to cases where everyone agrees a good thing has been done, like asking pregnant women not to drink, or teaching high-risk men parenting skills. We call these “preventing fetal alcohol syndrome” and “preventing child abuse”, and it’s equally fair to call polygenic selection “preventing schizophrenia”.
primary visual cortex1 mentions across 1 issues

primary visual cortex is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between July 19, 2024 and July 19, 2024. The archive places it in contexts such as "well-studied sensory areas like the primary visual cortex". It most often appears alongside Alan Turing, Amazon, Amazon jungle.

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primary visual cortex
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1
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1
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July 19, 2024
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July 19, 2024
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Your Book Review: How Language Began
July 19, 2024 · Original source
I have to say, I am not 100% convinced by the brain arguments. I mean, come on, look at the videos of people with Broca’s aphasia or Wernicke’s aphasia. Also, I buy that Broca’s and Wernicke’s areas (or whatever other putative language areas are out there) are active during non-language-related behavior, or that they represent non-language-related variables. But this is also true of literally every other area we know of in the brain, including well-studied sensory areas like the primary visual cortex. It’s no longer news when people find variable X encoded in region Y-not-typically-associated-with-X.
Inline links: Broca’s aphasia, Wernicke’s aphasia, primary visual cortex
Prime Directive1 mentions across 1 issues

Prime Directive is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between April 30, 2021 and April 30, 2021. The archive places it in contexts such as "Federation ships would Prime-Directive right over". It most often appears alongside AI, AI research, Air.

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Prime Directive
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1
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April 30, 2021
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April 30, 2021
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Your Book Review: The Wizard And The Prophet
April 30, 2021 · Original source
According to the instructions on the tin, The Wizard and the Prophet is meant to outline the origin of two opposing attitudes toward the relationship between humans and nature through their genesis in the work and thought of two men: William Vogt, the "Prophet" polemicist who founded modern-day environmentalism, and Norman Borlaug, the "Wizard" agronomist who spearheaded the Green Revolution. Roughly speaking, Wizards want continual growth in human numbers and quality of life, and to use science and technology to get there: think Gene Roddenbury’s wildest dreams, full of replicators and quantum flux-harnessing doodads that untether us from our eons-long project of survival on limited resources and allow us to expand limitlessly. "Prophets'' believe that we can’t keep growing our population or impact on the world without eventually destroying it, and ourselves along with it. Their ideal future is like one of those planets the Federation ships would Prime-Directive right over, where humankind scales back and lives in harmony with the land, taking just enough to sustain our (smaller) numbers and allowing the intricate web of human and non-human creatures to flourish.
Inline links: Green Revolution
prime editing1 mentions across 1 issues

prime editing is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between October 13, 2025 and October 13, 2025. The archive places it in contexts such as "use prime editing, a new genetic technology". It most often appears alongside 2023, Aaron Silverbook, ACX Grants.

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prime editing
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1
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1
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October 13, 2025
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October 13, 2025
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ACX Grants Results 2025
October 13, 2025 · Original source
Kasey Markel, $10K, for genetically engineered corn. Kasey and his team at Semilla Nueva use prime editing, a new genetic technology, to create corn which is rich in zinc, iron, essential amino acids, and other nutrients frequently deficient in corn-heavy poor country diets. Our grant helps fund greenhouse space, enzymes, DNA synthesis, and scientist time, and will let them expand faster into new regions that require corn with different genetic backgrounds.
Prime Influencer1 mentions across 1 issues

Prime Influencer is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between January 16, 2026 and January 16, 2026. The archive places it in contexts such as "the characters find the Prime Influencer. She is able to come up with a short snappy slogan". It most often appears alongside Adams, Alice, All-Seeing Eye.

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Prime Influencer
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1
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1
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January 16, 2026
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January 16, 2026
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The Dilbert Afterlife
January 16, 2026 · Original source
In the thrilling climax, which takes place at Stacey’s Cafe (yes, it’s the real-world restaurant Adams was managing - yes, he turned his religious-apocalyptic thriller novel into an ad for his restaurant - yes, I bet he thought of this as a “hypnotic suggestion”), the characters find the Prime Influencer. She is able to come up with a short snappy slogan so memetically powerful that it defeats fundamentalist religion and ends the war (the slogan is: “If God is so smart, why do you fart?”). Adams’ mouthpiece character says:
Prime Minister of Egypt1 mentions across 1 issues

Prime Minister of Egypt is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between November 17, 2023 and November 17, 2023. The archive places it in contexts such as "Joseph becomes as close to a god ... (Prime Minister of Egypt)". It most often appears alongside Abel, Adam and Eve, America.

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1
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1
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November 17, 2023
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November 17, 2023
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Book Review: I See Satan Fall Like Lightning
November 17, 2023 · Original source
He contrasts this with the Bible. Lots of Bible stories also fit the pattern. As in Babylonian and Norse mythology, the world begins with a primordial murder: Cain kills Abel. But the clearest example is the story of Joseph and his brothers. Joseph’s brothers grow jealous of him, coveting his beautiful multi-colored coat. They form a mob, gang up on him, and are about to kill him, when a slave caravan comes by and they decide to sell him as a slave instead. Then Joseph becomes as close to a god as the monotheistic Israelites are willing to accept (Prime Minister of Egypt) and founds the next stage of Israelite civilization as some kind of culture-hero figure.
priming1 mentions across 1 issues

priming is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between August 31, 2023 and August 31, 2023. The archive places it in contexts such as "Psychologists have been researching priming since the 1950s". It most often appears alongside Against Automaticity, Banana, Buddha.

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priming
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1
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1
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August 31, 2023
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August 31, 2023
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Here's Why Automaticity Is Real Actually
August 31, 2023 · Original source
An explanation of why tricks like priming, nudge, the placebo effect, social contagion, the “emotional inception” model of advertising, most “cognitive biases,” and any field with “behavioral” in its name are not real.
My summary (as always, read the real thing to keep me honest): for a lot of the ‘90s and ‘00s, social scientists were engaged in the project of proving “automaticity”, the claim that most human decisions are unconscious/unreasoned/automatic and therefore bad. Cognitive biases, social priming, advertising science, social contagion research, “nudges”, etc, were all part of this grand agenda.
For example, consider John Bargh’s famous (and now debunked) social priming studies: an experimenter would make subjects solve word games related to elderly people (eg WRINKLE, OLD, CANE). These subjects would then walk out of the laboratory more slowly than control subjects, because they’d been “primed” with the thought of old people, who move slowly. Again, this has since been debunked. But for a while, it seemed like half of all psych experiments were something along these lines. And they all sent the same message: “you” are not in command. You are like a leaf, being blown about by environmental factors beyond your control - how people phrase things, what your peers are doing, and which words you’ve encountered recently.
Prince of Wales1 mentions across 1 issues

Prince of Wales is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between August 01, 2025 and August 01, 2025. The archive places it in contexts such as ""Prince of Wales" in England". It most often appears alongside Africa, Agamemnon, Age of Empires II.

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Prince of Wales
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1
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1
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August 01, 2025
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August 01, 2025
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Your Review: Joan of Arc
August 01, 2025 · Original source
The title of Dauphin is that of the heir to the French throne, like "Prince of Wales" in England.
princeling1 mentions across 1 issues

princeling is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between April 06, 2022 and April 06, 2022. The archive places it in contexts such as "That made Xi a “princeling”, ie a descendant of Communist “royalty”"; "princeling, ie a descendant of Communist “royalty”". It most often appears alongside America, American consulate, Attorney General.

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princeling
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1
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1
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April 06, 2022
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April 06, 2022
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Dictator Book Club: Xi Jinping
April 06, 2022 · Original source
Xi’s father, Xi Zhongxun, was former Vice-President of China. That made Xi a “princeling”, ie a descendant of Communist “royalty”. China-watchers disagree on how organized the princelings are and whether they count as a “faction”. But they’re at least kind of a faction, and it didn’t hurt that he represented them too.
Princes of the Earth1 mentions across 1 issues

Princes of the Earth is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between January 04, 2022 and January 04, 2022. The archive places it in contexts such as "rinces of the Earth". It most often appears alongside AGI, America, Asian Scientist.

Reference entry
Princes of the Earth
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1
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1
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January 04, 2022
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January 04, 2022
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Movie Review: Don't Look Up
January 04, 2022 · Original source
In the Erin Brockovich narrative, Science is the simple truth, the hard physical reality behind the veil of establishment lies and corporate distortion. If a thousand PhDs say one thing, and a humble grocery-bagger says another, but the grocery bagger is backed by reason and experimental evidence, then the grocery-bagger gets the mantle of Science, and the PhDs must gnash their teeth in vain. When God entered the world, it was through a poor Jewish carpenter, in order to humble all the kings and princes of the Earth; when Science enters the world, it’s through Swiss patent clerks, or Hungarian women from third-tier colleges, for the same reason. Magellan supposedly said that “the Church says the Earth is flat, but I know that it is round, for I have seen its shadow on the moon, and I have more faith in the shadow than in the Church.” Science is observing the shadow and telling the Church to screw itself.
principal-agent problem1 mentions across 1 issues

principal-agent problem is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between July 21, 2023 and July 21, 2023. The archive places it in contexts such as "This is the principal-agent problem. Whenever the person investing the money is not also providing the capital". It most often appears alongside 2008 Financial Crisis, 2023 book review contest, 30-Year Mortgage.

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1
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1
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July 21, 2023
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July 21, 2023
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Your Book Review: The Laws of Trading
July 21, 2023 · Original source
This is the principal-agent problem. Whenever the person investing the money is not also providing the capital, you’re going to have problems.
Principle of Charity1 mentions across 1 issues

Principle of Charity is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between October 13, 2021 and October 13, 2021. The archive places it in contexts such as "We talk about the Principle of Charity here a lot". It most often appears alongside Anatoly Karlin, atomic bomb, C.S. Lewis.

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Principle of Charity
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1
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1
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October 13, 2021
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October 13, 2021
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Highlights From The Comments On Kids And Climate Change
October 13, 2021 · Original source
We talk about the Principle of Charity here a lot, and most of you are willing to grant it to right-wingers. If this was the post about how some people really do oppose abortion for moral reasons, and it’s not just sexism - or how some people really do oppose immigration for cultural reasons, and it’s not just racism - or anything along these lines, everyone would be on board. But I think this ethos of acknowledging that people can be honest and have principles, and not immediately jump to “they’re making it up” cuts both ways. Some people are actually really concerned about global warming.
Inline links: really do oppose abortion for moral reasons, really do oppose immigration for cultural reasons
Principle of Distinction1 mentions across 1 issues

Principle of Distinction is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between July 01, 2022 and July 01, 2022. The archive places it in contexts such as "the Principle of Distinction and other agreements made about how to behave during war". It most often appears alongside 1793, 1821, 1847.

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1
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1
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July 01, 2022
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July 01, 2022
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Your Book Review: The Internationalists
July 01, 2022 · Original source
The US keeps starting or engaging in wars, like in Libya, Afghanistan, and Iraq. I will briefly summarize the 3 major sections of the book and how they tackle the first five claims. Section 1: The Old World Order This section refutes the claim that outlawry of war wasn't actually a significant change for anyone at the time. To do so, it covers the history of the international laws of war as described by Hugo Grotius in a set of books titled The Law of War and Peace, including how he came to write it, what the laws were, and how they were used and understood. In this section, H&S work to fully immerse us in the laws of war before the Peace Pact, and the ways that people understood war as a result. I’ve already included a number of things about this up above, so I’ll just put in a few interesting notes here, and if you want more persuasion that people viewed war differently, I’d suggest you pick up the book. There is lots of historical evidence that attitudes toward war before the Peace Pact were not like attitudes toward war today, that people - lawyers, diplomats, sovereigns, and citizens - believed it to be normal and legal, and frequently justified. Conquest in response to debts or offenses was one of the primary motivators of war in the period ruled by the Old World Order (generally, from some time before 1625 when Grotius wrote the rules down to 1928, when the Peace Pact was signed), though H&S also document some of the weirder ones, like a King who declared that they had the right to wage war against another because the other King stole his wife. But because Grotius had declared that no one outside the belligerents could determine whose side was just without violating neutrality, the reasons for war were largely whatever Monarchs could get away, which ran the gamut. Perhaps because it was fashionable, perhaps to convince their citizenry of their rightness, Monarchs paid handsomely for famous thinkers to write manifestos explaining why they were going to war, and other Monarchs and the citizenry generally accepted these reasons. It would be like if Putin had called up Google co-founder Sergey Brin and asked him to write out why Russia had the right to conquer Ukraine, and then everyone else shrugged and decided, sure, that sounds reasonable. Heads of state enlisted esteemed writers and scholars as well as experienced lawyers to draft [war manifestos]. The English military and political leader Oliver Cromwell commissioned John Milton, the great epic poet, to write A Manifesto of the Lord Protector of the Commonwealth in 1655 when he ordered the invasion of the Spanish possessions in the Caribbean. In 1703, the Holy Roman Emperor Leopold I employed Gottfried Leibniz, the rationalist philosopher, co-inventor of calculus, and a trained lawyer, to compose the Manifesto for the Defense of the Rights of Charles III, which defended the empire’s involvement in the War of the Spanish Succession. Commodore Perry arrived in Japan in 1853 and returned for real the next year. Because they were so confused about how the laws of war were supposed to work, Japan proceeded to send Nishi Amane to the Netherlands to study the Law of War and Peace, and twenty years later, in 1875, Japan conquered Korea. Their logic for doing so was that they were afraid Europe or China would get there first. The world recognized their conquest at the time, though after WWII they were made to give it up. Korea was alluring prey for aggressive Western nations. As Nishi Amane [the scholar who brought the Grotian rules to Japan] would later explain, defending one’s borders “is like riding in a third-class train; at first there is adequate space but as more passengers enter there is no place for them to sit. The logic of necessity requires the people to plant both feet firmly and expand their elbows into any opening that may occur for, unless this is done, others will close the opening. (Chapter 6) Section 2: The Transformation Period Recall our list of counterclaims, #s 2 and 3. 2. Outlawry wasn't taken seriously at the time by the signatories - that it was just feel-good propaganda. 3. World War II proves that it failed, so it wasn't important. This section tells the story of how the Peace Pact came into existence, including how influential it was on the thinkers of the time. Throughout the 1930s and 40s, thinkers and diplomats attempted to turn the Peace Pact into practice, and then, when World War II demonstrated that they needed significantly more teeth to make the Peace Pact real, created the United Nations and other international institutions dedicated to supporting the Pact’s goals. At the time, they viewed World War II as a sign that they hadn’t gotten the right combination of institutions to make the Peace Pact succeed, not that it wasn’t important. This was a classic situation of needing More Dakka and they did, indeed, keep adding more until it worked. In an account composed more than a decade later, Jackson recounted that this view of the Pact was shared by the president and his inner circle. The Peace Pact, he reported, “left no vestige of legal right for [a state] to resort to a war of aggression. From the beginning, Roosevelt, Hull, Welles, Stimson and I had been in agreement that Hitler’s war . . . was an illegal one, and that other powers were under no obligation to remain indifferent. (Chapter 11) There is some counter-evidence in support of #2, from the side of the Japanese at least. Japan, for example, did not think that it had renounced the rules of the Old World Order on August 27, 1928. Its signing of the “No-War Pact,” as the Paris Peace Pact was known in Japan, was regarded as a diplomatic gesture, a noble proclamation affirming the aspiration of all civilized nations to seek peace. Indeed, Japanese officials considered it a sign of how far their nation had come that it was included among the fifteen countries at the grand ceremony in Paris. (Chapter 7) But at least on the Allies side, they had intended it seriously, and as World War II went on, that intention redoubled. Sumner Welles, Undersecretary of State during World War II, was assigned by Roosevelt to create a plan for peace after the war. What he and James Shotwell authored was effectively an outline of the United Nations, and they put the Peace Pact at the very center of it. Shotwell was far from subtle about his effort to treat the Pact as a starting point. He placed the Pact at the start of his preliminary draft. Article 1 repeated the Pact verbatim. Article 2 provided that “[t]he United Nations, in order to strengthen and safeguard the peace of nations as set forth in the General Pact for the Renunciation of war, agree to cooperate in the establishment of the necessary instrumentalities for its effective maintenance.” What followed was an outline of nearly every essential institutional component of the modern-day United Nations. Ten days later he circulated a more detailed draft, now entitled “Provisional Outline of International Organization.” (Chapter 8) It wasn't just the United Nations. NATO was built off of the Atlantic Charter, and it was also designed to reinforce the Peace Pact. This is why it's reasonably accurate to describe it as a defensive alliance. The [first draft of the Atlantic Charter] was a remarkable document. It began by restating the principles of the Stimson Doctrine—there would be no conquest; the two countries would “seek no aggrandizement, territorial or other.” Moreover, there would be “no territorial changes that do not accord with the freely expressed wishes of the peoples concerned.” The Charter looked ahead to a time “after the final destruction of the Nazi tyranny”—a remarkable statement for a neutral in the war—and declared the two states’ “hope to see established a peace which will afford to all nations the means of dwelling in safety within their own boundaries. (Chapter 8) This section brings to bear quotes from leaders at the time showing how important they considered the outlawry of war, how they viewed it as changing the world, but also how unprepared they were for how to react to countries choosing to ignore the Pact. Most importantly, they show how the Allies were strongly motivated to fight World War II specifically to preserve and expand the Pact, to make the world safe for peace. Unfortunately, then, as now, Russia/the Soviet Union did not quite live up to the ideals that the Allies generally advocated for. The Soviet Union took territory after World War II, the only one of the Allies to do so. The only ally to gain any significant territory after the war was the Soviet Union. More than twenty million of the nation’s citizens had died in the course of the war, and Stalin insisted on several territorial gains as the price of peace—many, but not all, of them in areas previously contested. … These concessions to Stalin were seen by the other Allied powers as regrettable deviations from accepted law, not precedents to be followed in the future. (Chapter 13) To be fair, we are talking about Josef Stalin, here. Who’s surprised? Section 3: The New World Order Recall our list of counterclaims, #s 4 and 5. 4. The world isn't more peaceful post outlawry. 5. Any increase in peace since World War II is due to democracies, nuclear weapons, or other reasons, and not the Peace Pact. H&S walk through the best academic evidence we have of whether the world is more peaceful today than it was in the period from 1816 (when our data collection starts being decent) to the Peace Pact. They then spend some time discussing why the evidence better supports the Peace Pact than other causes. In particular, H&S highlight that only since the Peace Pact have countries been denied territorial gains from their conquests. There's a lot of detail in there. Here's just a taste of it. A loose team of political scientists has assembled comprehensive data to help them study war. The resulting project, with the intentionally clinical name “Correlates of War,” hosts datasets on everything from “militarized interstate disputes” to “world religion data” to “bilateral trade.” Most relevant here, it includes extensive data on “territorial change”—a record of every single territorial exchange between states from 1816 to 2014, totaling over eight hundred entries. What do our 254 cases of territorial change tell us? They tell us something that is at once striking and surprising: Conquest, once common, has nearly disappeared. Even more unexpected, the switch point is that now familiar year when the world came together to outlaw war, 1928. From the time the data start in 1816 until the Peace Pact opened for signature in 1928, there was, on average, approximately one conquest every ten months (1.21 conquests per year). Put another way, the average state during this period had a 1.33 percent chance of being the victim of conquest in any given year. Those may seem like pretty good odds. They are not: A state with a 1.33 percent annual chance of conquest can expect to lose territory in a conquest once in an ordinary human lifetime. After 1948, the chance an average state would suffer a conquest fell from once in a lifetime to once or twice a millennium. (Chapter 13) The US wars in Afghanistan, Iraq, and Libya One disappointment I have is that H&S do not spend much time discussing the US wars of the last two decades. The book was published in 2017, so there’s really no excuse for this. Even counting them, their claim that wars since the Peace Pact have been fewer and less world-changing than before the Peace Pact still holds up, but since they don’t directly discuss the most notable wars of the last two decades, they leave a significant hole in their argument. I can imagine defenses that they would make, but they should have made them. They mostly refer to these conflicts either as not a conquest (since the US isn’t officially running those places now) or as a side effect of the Peace Pact in allowing failed states (See Addendum 1 for more on that) More recently, the United States invaded Iraq in 2003, toppled Sadaam Hussein, and installed the Coalition Provisional Authority to govern the country. But what’s most notable about these “nonconquests” is how ineffective and unstable they usually are. Exerting influence indirectly is inefficient and expensive. (Chapter 13) And in 2015 alone, high-fatality civil wars continued in Nigeria, South Sudan, Yemen, Syria, Iraq, Afghanistan, Pakistan, Somalia, and Ukraine. Why, if war has been outlawed, is there still so much conflict? The answer is that these conflicts are not prohibited by the Pact. Indeed, they are the predictable consequences of it … the prohibition on the use of force by one state against the territory of another has allowed two sources of conflict to simmer… within [states]. (Chapter 15) The broader intellectual history of war Reading The Internationalists led me to want to read a broader intellectual history of war. H&S include some comments that hint at it, for example describing the Principle of Distinction and other agreements made about how to behave during war. Fortunately for the civilians of Europe, the biblical model of war was finally repudiated. By the middle of the eighteenth century, European armies had come to recognize a “Principle of Distinction,” the doctrine central to modern humanitarian law, which distinguishes between soldiers and civilians and protects the latter from the former. The Principle of Distinction was the first curtailment of Grotius’s blanket immunity for those waging war. In the next century, it was followed by a flood of new legal regulations placing stricter controls on a soldier’s license to kill. International treaties protected the wounded and medical personnel (First Geneva Convention, 1864) prohibited the use of fragmenting, explosive, and incendiary small arms ammunition (St. Petersburg Declaration, 1874) banned explosives from balloons, asphyxiating gas, and dum-dum bullets (First Hague Convention, 1899) and proscribed pillage, the execution of surrendering soldiers and prisoners of war, and forcing civilians to swear an allegiance to a foreign power (Second Hague Convention, 1907). (Chapter 3) But the history of this and other pre-Peace Pact intellectual history of war is thin within the text, as the point H&S are chasing is specific to the Peace Pact's relevance in history, not the broader history of war. Some of my favorite books are books that tie together aspects of history across wide gulfs, which The Internationalists succeeds at. It’s rare and delightful to see how a piratical ship capture by the Dutch in the 16th century ties together with the opening of Japan, the US battles with Mexico, and finally, the creation of the United Nations. H&S’s perspective is that the Peace Pact marks a turning point, and one that should not be forgotten. It’s also clear that it marks a capstone on a long history of small changes that are also, themselves, interesting battles in the long-running war to make the world less intolerable. In the end, they identify four key changes in the intellectual landscape, with Lauterpacht’s fingers in nearly all of them. Neutrality no longer requires impartiality. States can help those they view as victims.
Inline links: More Dakka
principles and parameters1 mentions across 1 issues

principles and parameters is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between July 19, 2024 and July 19, 2024. The archive places it in contexts such as "the core idea of the so-called ‘principles and parameters’ formulation of universal grammar". It most often appears alongside Alan Turing, Amazon, Amazon jungle.

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1
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1
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July 19, 2024
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July 19, 2024
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Your Book Review: How Language Began
July 19, 2024 · Original source
bedobi, Redditor Apparently he struck a nerve. And there is much more vitriol like this; see Pullum for the best (short) account of the beef I’ve found, along with sources for each quote except the last. On the whole affair, he writes: Calling it a controversy or debate would be an understatement; it was a campaign of vengeance and career sabotage. I’m not going to rehash all of the details, but the conduct of many in the pro-Chomsky faction is pretty shocking. Highly recommended reading. Substantial portions of the books The Kingdom of Speech and Decoding Chomsky are also dedicated to covering the beef and related issues, although I haven’t read them. What’s going on? Assuming Everett is indeed acting in good faith, why did he get this reaction? As I said in the beginning, linguists are those who believe Noam Chomsky is the rightful caliph. Central to Chomsky’s conception of language is the idea that grammar reigns supreme, and that human brains have some specialized structure for learning and processing grammar. In the writing of Chomsky and others, this hypothetical component of our biological endowment is sometimes called the narrow faculty of language (FLN); this is to distinguish it from other (e.g., sensorimotor) capabilities relevant for practical language use. A paper by Hauser, Chomsky, and Fitch titled “The Faculty of Language: What Is It, Who Has It, and How Did It Evolve?” was published in the prestigious journal Science in 2002, just a few years earlier. The abstract contains the sentence: We hypothesize that FLN only includes recursion and is the only uniquely human component of the faculty of language. Some additional context is that Chomsky had spent the past few decades simplifying his theory of language. A good account of this is provided in the first chapter of Chomsky’s Universal Grammar: An Introduction. By 2002, arguably not much was left: the core claims were that (i) grammar is supreme, (ii) all grammar is recursive and hierarchical. More elaborate aspects of previous versions of Chomsky’s theory, like the idea that each language might be identified with different parameter settings of some ‘global’ model constrained by the human brain (the core idea of the so-called ‘principles and parameters’ formulation of universal grammar), were by now viewed as helpful and interesting but not necessarily fundamental. Hence, it stands to reason that evidence suggesting not all grammar is recursive could be perceived as a significant threat to the Chomskyan research program. If not all languages had recursion, then what would be left of Chomsky’s once-formidable theoretical apparatus? Everett’s paper inspired a lively debate, with many arguing that he is lying, or misunderstands his own data, or misunderstands Chomsky, or some combination of all of those things. The most famous anti-Everett response is “Pirahã Exceptionality: A Reassessment” by Nevins, Pesetsky, and Rodrigues (NPR), which was published in the prestigious journal Language in 2009. This paper got a response from Everett, which led to an NPR response-to-the-response. To understand how contentious even the published form of this debate became, I reproduce in full the final two paragraphs of NPR’s response-response: We began this commentary with a brief remark about the publicity that has been generated on behalf of Everett's claims about Pirahã. Although reporters and other nonlinguists may be aware of some ‘big ideas’ prominent in the field, the outside world is largely unaware of one of the most fundamental achievements of modern linguistics: the three-fold discovery that (i) there is such a thing as a FACT about language; (ii) the facts of language pose PUZZLES, which can be stated clearly and precisely; and (iii) we can propose and evaluate SOLUTIONS to these puzzles, using the same intellectual skills that we bring to bear in any other domain of inquiry. This three-fold discovery is the common heritage of all subdisciplines of linguistics and all schools of thought, the thread that unites the work of all serious modern linguists of the last few centuries, and a common denominator for the field. In our opinion, to the extent that CA and related work constitute a ‘volley fired straight at the heart’ of anything, its actual target is no particular school or subdiscipline of linguistics, but rather ANY kind of linguistics that shares the common denominator of fact, puzzle, and solution. That is why we have focused so consistently on basic, common-denominator questions: whether CA’s and E09’s conclusions follow from their premises, whether contradictory published data has been properly taken into account, and whether relevant previous research has been represented and evaluated consistently and accurately. To the extent that outside eyes may be focused on the Pirahã discussion for a while longer, we would like to hope that NP&R (and the present response) have helped reinforce the message that linguistics is a field in which robustness of evidence and soundness of argumentation matter. Two observations here. First, another statement about “serious” linguistics; why does that keep popping up? Second, wow. That’s the closest you can come to cursing someone out in a prestigious journal. Polemics aside, what’s the technical content of each side’s argument? Is Pirahã recursive or not? Much of the debate appears to hinge on two things: what one means by recursion
Inline links: bedobi, Pullum, The Kingdom of Speech, Decoding Chomsky, The Faculty of Language: What Is It, Who Has It, and How Did It Evolve?, principles and parameters, Pirahã Exceptionality: A Reassessment, response from Everett, response-to-the-response
printing press1 mentions across 1 issues

printing press is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between March 30, 2023 and March 30, 2023. The archive places it in contexts such as "No one at the beginning of the printing press had any real idea of the changes it would bring". It most often appears alongside 21st century American society, AGI, Eliezer.

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printing press
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1
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1
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March 30, 2023
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March 30, 2023
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MR Tries The Safe Uncertainty Fallacy
March 30, 2023 · Original source
Therefore, it’ll be fine. You’re not missing anything. It’s not supposed to make sense; that’s why it’s a fallacy. For years, people used the Safe Uncertainty Fallacy on AI timelines: Eliezer didn’t realize that at our level, you can just name fallacies. Since 2017, AI has moved faster than most people expected; GPT-4 sort of qualifies as an AGI, the kind of AI most people were saying was decades away. When you have ABSOLUTELY NO IDEA when something will happen, sometimes the answer turns out to be “soon”. Now Tyler Cowen of Marginal Revolution tries his hand at this argument. We have absolutely no idea how AI will go, it’s radically uncertain: No matter how positive or negative the overall calculus of cost and benefit, AI is very likely to overturn most of our apple carts, most of all for the so-called chattering classes. The reality is that no one at the beginning of the printing press had any real idea of the changes it would bring. No one at the beginning of the fossil fuel era had much of an idea of the changes it would bring. No one is good at predicting the longer-term or even medium-term outcomes of these radical technological changes (we can do the short term, albeit imperfectly). No one. Not you, not Eliezer, not Sam Altman, and not your next door neighbor. How well did people predict the final impacts of the printing press? How well did people predict the final impacts of fire? We even have an expression “playing with fire.” Yet it is, on net, a good thing we proceeded with the deployment of fire (“Fire? You can’t do that! Everything will burn! You can kill people with fire! All of them! What if someone yells “fire” in a crowded theater!?”). Therefore, it’ll be fine: I am a bit distressed each time I read an account of a person “arguing himself” or “arguing herself” into existential risk from AI being a major concern. No one can foresee those futures! Once you keep up the arguing, you also are talking yourself into an illusion of predictability. Since it is easier to destroy than create, once you start considering the future in a tabula rasa way, the longer you talk about it, the more pessimistic you will become. It will be harder and harder to see how everything hangs together, whereas the argument that destruction is imminent is easy by comparison. The case for destruction is so much more readily articulable — “boom!” Yet at some point your inner Hayekian (Popperian?) has to take over and pull you away from those concerns. (Especially when you hear a nine-part argument based upon eight new conceptual categories that were first discussed on LessWrong eleven years ago.) Existential risk from AI is indeed a distant possibility, just like every other future you might be trying to imagine. All the possibilities are distant, I cannot stress that enough. The mere fact that AGI risk can be put on a par with those other also distant possibilities simply should not impress you very much. So we should take the plunge. If someone is obsessively arguing about the details of AI technology today, and the arguments on LessWrong from eleven years ago, they won’t see this. Don’t be suckered into taking their bait. Look. It may well be fine. I said before my chance of existential risk from AI is 33%; that means I think there’s a 66% chance it won’t happen. In most futures, we get through okay, and Tyler gently ribs me for being silly. Don’t let him. Even if AI is the best thing that ever happens and never does anything wrong and from this point forward never even shows racial bias or hallucinates another citation ever again, I will stick to my position that the Safe Uncertainty Fallacy is a bad argument. Normally this would be the point where I try to steelman Tyler and explain in more detail why the strongest version of his case is wrong. But I’m having trouble figuring out what the strong version is. Here are three possibilities: 1) The base rate for things killing humanity is very low, so we would need a strong affirmative argument to shift our estimate away from that base rate. Since there’s so much uncertainty, we don’t have strong affirmative arguments, and we should stick with our base rate of “very low”. Suppose astronomers spotted a 100-mile long alien starship approaching Earth. Surely this counts as a radically uncertain situation if anything does; we have absolutely no idea what could happen. Therefore - the alien starship definitely won’t kill us and it’s not worth worrying? Seems wrong. What’s the base rate for alien starships approaching Earth killing humanity? We don’t have a base rate, because we’ve never been in this situation before. What is the base rate for developing above-human-level AI killing humanity? We don’t . . . you get the picture. You can try to fish for something sort of like a base rate: “There have been a hundred major inventions since agriculture, and none of them killed humanity, so the base rate for major inventions killing everyone is about 0%”. But I can counterargue: “There have been about a dozen times a sapient species has created a more intelligent successor species: australopithecus → homo habilis, homo habilis → homo erectus, etc - and in each case, the successor species has wiped out its predecessor. So the base rate for more intelligent successor species killing everyone is about 100%”. The Less Wrongers call this game “reference class tennis”, and insist that the only winning move is not to play. Thinking about this question in terms of base rates is just as hard as thinking of it any other way, and would require arguments for why one base rate is better than another. Tyler hasn’t made any. 2) There are so many different possibilities - let’s say 100! - and dying is only one of them, so there’s only a 1% chance that we’ll die. This is sort of how I interpret: Existential risk from AI is indeed a distant possibility, just like every other future you might be trying to imagine. All the possibilities are distant, I cannot stress that enough. The mere fact that AGI risk can be put on a par with those other also distant possibilities simply should not impress you very much. Alien time again! Here are some possible ways the hundred-mile long starship situation could end: The aliens are peaceful and want to share their advanced technology
Inline links: https://substackcdn.com/image/fetch/$s_!jYyh!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F672bd8f5-484b-48ff-a80f-539d7b77b66c_599x238.png, sort of qualifies as an AGI, tries his hand at this argument
prion1 mentions across 1 issues

prion is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between July 12, 2024 and July 12, 2024. The archive places it in contexts such as "Had infectious prions been in Pasteur’s flask, curative medicine would never have gotten started". It most often appears alongside 1980s, 1989, 1990s.

Reference entry
prion
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1
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1
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July 12, 2024
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July 12, 2024
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Your Book Review: The Family That Couldn’t Sleep
July 12, 2024 · Original source
(This report was, as it happens, published in the exact same month as The Family That Couldn’t Sleep.) DTM came to know the family well. He befriended them by way of two members of their younger generation, Lisi – a woman terrified by the shadow of the disease, and Ignazio – the doctor she had married, who was more terrified by the shadow of the disease. Ignazio put together the pieces of the family puzzle, consolidating all the disparate diagnoses into a single disorder and filling out a lot of blank spots on family trees. When DTM came along, he was able to help Ignazio make the case that the family would benefit from the spotlight – that greater awareness of FFI could lead to a cure both for them and for a slew of other prion diseases. As it so happens, he is one of those nonfiction authors who serve as a character in their own story. DTM has some form of progressive muscular palsy. He is, or at least was in 2006, not entirely sure what it is. The relatively unimpressive state of genetics at the time had not identified his causative mutation, though it looked a lot like one of the rarer forms of Charcot-Marie-Tooth disease2. DTM is pragmatic about this, the way everyone chronically ill is either pragmatic or doomed. Whatever he has, it is a defect in protein structure; his peripheral nerves decay not because of a problem with the nerves themselves but an inability of their scaffolding to hold them together, as he puts it. The last chapter of the book dwells on this, on the web of connections popping up between a thousand disorders. DTM’s disease is something vaguely similar, if you squint, to an exceptionally slow-progressing motor neurone disease; if you jump another level out, you see amyloid plaque diseases like Huntington’s and Alzheimer’s, and if you jump yet another level out, you see something like prions. His interest in the Venetian family was driven by this. Some of its members thought this a beautiful act of sympathy; others thought him a grotesque parody of themselves, an onlooker, a gawker, peddling their tragedy to salve his relatively insignificant problems. They are, he thinks, both right. That’s the beginning, and that’s the end. What happens in the middle? --------------------------------------------------------- The Venetian family lends the book its title, but they’re really more of a framing device. The Family That Couldn’t Sleep is separated into four parts, of which the first and fourth – the shortest by far – deal with the family. Part 2 is kuru, the king of fucked up diseases you read about in clickbait Weird Medicine listicles. Let’s talk about kuru! Kuru, is, famously, the prion disease you get if you eat another person’s brain. Well, not quite. It’s a prion disease that became endemic amongst women in the Fore society, who ritually ate brains, one of which had an inherited or spontaneous prion disease. This is an important note – there’s a tendency (which the book’s later chapters engage in) to assume cannibalism just has a Prion Disease Generator attached. If you eat people who don’t have prion diseases, you won’t suddenly get one. Uh, don’t eat people. Anyway, part 2 is DTM’s historiography of Fore-Westerner first contact. It’s hilarious. Papua New Guinea is a frankly ridiculous place; one of the all-time best Lyttle Lytton winners (worst first sentence from a hypothetical or, in this case, real work) was “Papua New Guinea is so violent that more than 820 languages are spoken there”. The native residents were so hostile to outsiders that all the colonial empires had cut their losses – and when you think about the places they colonized, that says something. After the First World War, PNG was ripped from its nominal German ‘owners’, but no one else wanted the place. So, of course, they gave it to the Australians. It was thirty years and another war before we actually made contact. 1940s Australia was as ‘settled’ as it’d ever be; the cities were bustling and the interior was mapped. The kind of explorer who two centuries before would be heading to new continents had to console himself with Pacific islands. Console he did. The native peoples of the PNG coasts were hostile enough to the wannabe-colonialists that the Australians, flying planes overhead, were the first people to discover that the island’s inland was populated too. No one had broken through on land. In all this deep and angry rainforest, the Fore were the furthest out. They lived far into the island’s mountainous interior; DTM describes their territory as “nearly vertical”. Calling people primitives is a bit passe these days for understandable reasons, but no other term comes to mind. The Fore had no name for themselves; we call them by an exonym, “the people to the south”. They weren’t, to be clear, hunter-gatherers – they were slash-and-burn agriculturalists, but very well-fed ones. Despite the tendency in grain-focused cultures for poor agriculturalists to be stunted/malnourished, the Fore were a remarkably healthy people. Well, except for the famous bit. The first remarkable thing about the Fore was just how quickly they wanted to assimilate. Most PNG tribes weren’t particularly enthused by Western offers of injections/tractors/radios/Christianity. Yet as soon as the Australians arrived, the Fore made ceasefires in their wars with other tribes, volunteered to help large-scale Australian projects on the coast, started planting and trading coffee, and enthusiastically participated in censuses. It’s the only first-contact narrative I’ve seen where the colonizers were concerned about how badly the other guys wanted to be colonized. The next was the one that got their names in the history books. Australian officials started to notice a remarkable lack of women in Fore camps. Some tribes sequestered their women, particularly when Westerners were around, so at first they thought nothing of it. The high rate of unpartnered young men, though, was way out of PNG norms. DTM tells this part fantastically. The Fore chapters drip with the dread of dramatic irony. When the first breakthrough comes, you have to catch your breath: “Tiny” Carey noted something in the middle of August 1950 that deepened this mystery. He noticed that near the village of Henganofi there had been an unusual number of deaths. “It appears,” he wrote his superiors, “natives suffer from stomach trouble, get violent shivering, as with the ague, and die fairly rapidly.” [...] McArthur investigated a little more [...] One day in August 1953 he ran into more of the shivering people Tiny Carey had seen several years before: “Nearing one of the dwellings, I observed a small girl sitting down beside a fire. She was shivering violently and her head was jerking spasmodically from side to side.” It would be quite some time before anyone figured out what caused it – but the problem, as DTM notes, was that its cause wasn’t possible. Everyone priored that the weird undescribed disease in the Fore lands was some nocebo sorcery-sickness. Vincent Zigas, the first actual doctor sent to work with the Fore, tried to placebo-effect them and failed miserably: On the way, Apekono stopped at a hut and showed Zigas his first kuru victim. “On the ground in the far corner sat a woman of about thirty,” the doctor wrote. “She looked odd, not ill, rather emaciated, looking up with blank eyes with a mask-like expression. There was an occasional fine tremor of her head and trunk, as if she were shivering from cold, though the day was very warm.” It was almost exactly the tableau McArthur had witnessed in 1953. Zigas, though, was a doctor. He could do more than look—or so he thought: “I decided I might as well try my own variety of magic,” he remembered. He rubbed Sloan’s Liniment, a balm for sore muscles, on her and declared to her family and his guide: “The sorcerer has put a bad spirit inside the woman. I am going to burn this spirit so that it comes out of her and leaves her. You will not see the fire, but she will feel it. The bad spirit will leave her and she will not die.” The lotion penetrated the woman’s skin and she writhed in pain. “Get up! Walk!” Zigas commanded theatrically. “The woman struggled feebly as if to rise, then, exhausted, started to tremble more violently, making a sound of foolish laughter, akin to a titter.” That evening Apekono asked Zigas not to try to cure any more kuru victims; “Don’t use your magic medicine anymore. It will not win our strong sorcery.” This was a disaster. The Fore were so cooperative precisely because they hoped “Western magic” could conquer theirs. As it became clear it couldn’t, they turned hostile. The Australians had hoped to “modernize a Stone Age people”; now all their subjects were dropping dead before their eyes, from what they could only assume was a “hysterical reaction” to colonization itself. So, to solve this, they needed a batshit insane American. Carleton Gajdusek is one of the characters who dominates The Family That Couldn’t Sleep. He couldn’t not. You could put him in a car commercial and he’d dominate it. Gajdusek was a physician with a rare, intense combination of science and practice. He was a romanticist, a field worker, and a lover of everything strange. He’d been an army doctor, a government conspiracy-cover-upper, and a postdoc under Linus Pauling who described his intent as “to straighten out Pauling’s ideas about proteins”. He hated civilization, in a slightly-to-Ted’s-centre sense, and was passionate about “primitives and isolates”. He jumped at the chance to work in Papua New Guinea; he planned to conduct a multi-site study on child development in such cultures, and relished the opportunity to live in a “primitive” environment himself. He did all this so he could rape kids. Oh, he did it for the scientific curiosity and love of medicine, but he also did it so he could rape kids. Gajdusek was a pedophile in the actual-lifelong-exclusive-paraphilia sense, as opposed to the “metonym for child molester” sense. Some people who roll snake-eyes on the Sexuality Dice repress it, but some are perfectly happy to act on it; Gajdusek was #2 in its fullest form, the kind of guy who believes that a well-lived life includes raping some kids. DTM doesn’t shy from this, not for a moment. It’s the first thing he tells you about Gajdusek. It couldn’t not be; you couldn’t talk about why he went to PNG otherwise. When Gajdusek landed in PNG, he first found the place too civilized. He’d been promised a land of “cannibal savages” – where were they? After some traipsing, he found them, right where he was promised. The Fore were perfect for Gajdusek. They had some kind of medical mystery that’d been lost on everyone else. They ate each other, in exactly the way he loved detailing in his diaries (“”Women and children, particularly, partake of the human flesh,” he noted with pleasure”). As kuru cases popped up, he aggressively recorded them. He wrote lovingly detailed notes that he sent back to his Australian advisor. He wrote with intensity, with exclamation marks, with the joie de vivre of a man just where he wanted to be. Gajdusek smothered the Fore with ‘cures’ that never worked, but they didn’t get angry at him. As DTM dryly puts it: “Their children trusted him, and that was enough for them.” At some point, someone suggested sending an anthropologist...or an epidemiologist...or literally anyone with more credentials than Gajdusek and Zigas3. Gajdusek threw a shitfit, convinced this one-and-a-half-man team was enough to Solve The Problem Forever. But he got bored eventually – running off with another tribe with, as his diary notes at length, an apparent custom of youths ritually fellating older men – and Zigas, I dunno, the book neglects him a bit here. So they managed to sneak in some anthropologists. The husband-and-wife team of Robert Glasse and Shirley Lindenbaum4 were the first involved parties to give a shit about the Fore as people, rather than as colonial subjects/medical mysteries/walking sex toys. What they uncovered was fascinating. The Fore were cannibals, yes, but they were recent cannibals. They didn’t have an ancient tradition of eating their dead, like the other visitors assumed. They happened to be in contact with some cannibal groups, and after a Fore man died of “sorcery”, they thought: well, what would happen if we ate him? “People tasting it expressed their approval. ‘”This is sweet,” they said, “What is the matter with us, are we mad? Here is good food and we have neglected to eat it.”” If not for the wild coincidence that the first Fore cannibalism victim had a prion disease, kuru would never have existed. Glasse and Lindenbaum started to put together the pieces. They’d been sent down to rule out a genetic explanation – to track the kinship ties of the Fore and see how the disease ran through families. It didn’t run through families in any coherent sense, but it sure did run through cannibalism. The clincher was the age distribution. The Fore, ever enthused by colonialism, quit eating each other as soon as the Australians arrived. Children stopped dying of kuru shortly after; they simply weren’t exposed to the infectious agent. The couple sent the news to Gajdusek, who was off raping kids somewhere else. In the next part of the book, DTM runs through Gajdusek’s many conjectures of kuru’s cause – more like sketches or abstract paintings than like true hypotheses. Gajdusek was annoyed that someone else was doing something he “totally could’ve done”, and even more annoyed that another lab was running similar experiments – an attempt at a vaccine for a particular sheep disease had accidentally created a prion generator. But he was happy to swoop in and claim the credit for what he was starting to think of as “slow viruses”, an infection that somehow lays dormant for years. DTM portrays Gajdusek perfectly, in that “real life has no need for verisimilitude” way. Gajdusek was at once a brilliant man, an all-consuming narcissist, an entertaining character, and a monster beyond redemption. A lesser book might pick one or two. The Family That Couldn’t Sleep portrays him as all four, and on a personality level (as opposed to a scientific one), the Gajdusek-focused parts are some of the most gripping. --------------------------------------------------------- Outside of the jumps between the Venetian family and everything else, The Family That Couldn’t Sleep is not siloed. The narratives of all prion diseases are deeply intertwined. This is what makes it a great book. It’s 300 pages of dramatic irony. You read the whole thing, waiting for the eureka moment – the point everyone realizes they’re looking at the same cause. It does, however, make it a tad difficult to review or synopsize. The book’s story is so weird – and, often, so at odds with conventional wisdom that trickles down about the Fore et al – that you have to recap quite a bit, and the book steadfastly resists recapping. The next couple chapters after we depart from Gajdusek’s credit-claiming are mostly about experiments with various prion diseases. They’re scientifically fascinating. Unlike some medical-books-for-general-audiences (cough, How Not to Study a Disease), DTM never talks down to the reader. He assumes someone reading a 300-page book about prions is smart and wants to learn about prions. He also has – you can feel it in his words – the agonizing experience of spending his life on the other side of the doctor’s desk, trying to beat into whoever he’s talking to that no, seriously, you don’t need to lie to him or try explain a complex disease at a fourth-grade level. The first prion disease studied was scrapie. Scrapie was a big deal – it starved and killed large shares of British sheep flocks, making it a serious economic problem. Veterinary researchers had tried to prevent or cure it for centuries. It was a veritable graveyard of ambitions: Quintessential was D. R. Wilson at the Moredun Institute in Scotland, who worked in the middle of the last century for more than a decade trying, with mounting frustration, to kill the scrapie agent. He found that it survived desiccation; dosing with chloroform, phenol, and formalin; ultraviolet light; and cooking at 100 degrees centigrade for thirty minutes. The scrapie researcher Alan Dickinson told me he remembered Wilson at the end of his career as “very, very, very quiet. Of course, that was after his breakdown.” “Now it is our turn to study prions. Perhaps we should approach the subject cautiously.” The problem, as DTM explains, is that prion diseases were impossible. They violated 20th-century understandings of biology. Proteins “were no more alive, and no more infectious, than bone”. Prion diseases seemed to have too many causes – genetic, infectious, and sporadic. They looked infection-like in some ways, but patients didn’t produce virus antibodies. Sheep exposed to scrapie, or chimps infected with kuru, took years to develop symptoms. Their facts did not fit together. In the 1960s, people started wondering. The unifying trait of prion agents was that they had to be denatured to be destroyed. Was this a particularly small virus defined by its protein coating? Or – even more outre – was it pure protein, no DNA at all? No one could figure out quite how the latter worked, but it was tempting. Gajdusek, by now a major figure in this field, kept a foot in both worlds. He didn’t want to stake his reputation on a no-DNA hypothesis, but he certainly sympathized. Enter Prusiner. Stanley Prusiner was Gajdusek’s counterpart. Where Gajdusek seemed permanently manic, Prusiner was deliberate and exacting. He entered Gajdusek’s “slow viruses” field in the early 1970s after a chance encounter with a CJD patient. He relished the laboratory in a way Gajdusek didn’t at all, and set out to optimize the hell out of his projects. Prusiner set out to isolate the smallest infectious particle in the scrapie agent. He injected tons of hamsters (hamsters got sick faster than mice) with increasingly tiny scrapie proteins, hoping to determine whether the Minimum Viable Scrapie was DNA. By the mid-1980s, he’d produced something so small it couldn’t possibly be a virus. Denaturing it destroyed it; exposing it to nucleic acid dissolvers actually made it stronger. Emboldened by this discovery, Prusiner set out to anoint himself the King of Prions. Here emerges something of a Voldemort-Umbridge distinction – the difference between cartoonish villainy and banal evil. Gajdusek is a bad guy because he rapes kids. Prusiner is a bad guy because he is the most grotesque stereotype of the Advisor/Peer Reviewer from Hell made flesh. Everything Prusiner did was to build his reputation atop a pile of skulls. When recruited as a peer reviewer for other prion papers, he wrote negative reviews to undermine their authors. He worked his grad students to the bone and intentionally destroyed their careers, telling them he’d “ruin them” if they entered prion research as competitors. He lied about the origin of the protein-only hypothesis, claiming he originated it a decade after it was actually conjectured. But hey, he was good at getting grants. I was surprised reading a lot of this, because for all the time I’ve been aware of it, the cause of prion disease has seemed settled. “Oh yeah, it’s a protein that gets all fucked up.” But DTM goes through just how unsettled it was right up through to The Family That Couldn’t Sleep’s publication. Serious confirmation only arrived a couple years later. Many people were deeply critical of the prion hypothesis – often, it seemed, because they loathed Prusiner too much to go along. Throughout the book, he cuts an uncharismatic figure. Gajdusek and Prusiner both won the Nobel for discovering prions, decades apart. This tells you something – the “discovery” of prions can be construed quite a few ways. Gajdusek formulated the hypothesis; Prusiner proved it. Gajdusek was grievously offended by Prusiner’s Nobel, perceiving his rival – not inaccurately – as a follower who never originated any ideas of his own. But Gajdusek was offended from a federal prison cell, so how’d that work out for him? Fascinating as all this is, no one published a book about prions in the mid-2000s because it was about kuru or FFI. They published books about prions because teenagers were dying, and people wanted to know why. DTM lays the seeds for part 3 – the mad cow section – in part 1. This is a discussion of scrapie, the longstanding prion disease of sheep. Scrapie was a medical mystery for centuries (remember poor D. R. Wilson), precisely because of the intuitive implausibility of prions. The scrapie chapter is a great history-of-science piece, covering the agricultural productivity revolutions of the 18th century, the surfeit of bizarre origins veterinarians concocted, and the treatments that never worked. Scrapie is not transmissible to humans – well, we hope. It’s concerningly transmissible to primates. But it’s been around for a long, long time, and it doesn’t epidemiologically look like humans get it...we hope. Anyway, you ever tried to generalize from one example? The British government did! In the mid-1980s, strange reports started coming out of the UK’s farms. Farmers were describing a new disease where dairy cows – incredibly docile creatures, under normal circumstances – turned hostile, kicking them as they went into the milking stalls. The symptoms looked to all the world like scrapie. Epidemiologists tracing the outbreaks found a unifying link with “cake” – animal protein feed sweetened with molasses. The scrapie-like symptoms must have traced to an infected sheep. But scrapie doesn’t transmit to humans, so it must be okay to keep slaughtering them, right? We all know how this ended. The best term for the British response to the mad cow outbreak is “cacklingly evil conspiracy”. The agricultural industry really, really didn’t need a huge zoonotic outbreak – so it decided it didn’t have one. They first suppressed all mentions that the disease looked like scrapie, then – when this became impossible – hyped up that scrapie doesn’t transmit to humans, so there’s nothing to worry about. The formal name of the disease, “bovine spongiform encephalopathy”, was supposedly chosen to optimize for unfamiliarity – it wouldn’t fit well in a headline. They emphasized, extensively, that there was nothing to worry about. Ever. At some point, people started asking questions. If there was nothing to worry about, why was the agricultural industry panicking so hard? As things became ever more worry-inducing, this turned down ludicrously twisting paths: Meanwhile, the Southwood Working Party and the experts who advised it were learning on the job. They learned, for instance, that the BSE agent entered the animal through the mouth and then followed the digestive tract into the organs that try to filter out infections—the tonsils, the guts, and the spleen—and from there traveled into the peripheral and central nervous system, and finally arrived at the brain. They also learned that pasties, meat pies, and even some baby foods contained tissues from a lot of those organs. So the Southwood Working Party recommended banning these organs, but only from baby food. This started a chain reaction of consumer doubt: if infected cow organs were unsafe for babies, how could they be good for adults? The government then banned offal, as the organs were collectively called, in all human food but gave the industry a grace period to get it out of the feed supply. Then pet food manufacturers began to wonder if what drove cows mad might not also drive dogs, cats, and parrots mad. The feed they sold came from concentrate made of the same sick animals that had previously made up the meat and bone meal farmers used. Their trade group decided to put a similar ban in place—immediately. So for five months it was safer to be a dog than a human in Britain. DTM spends pretty much this whole section of the book making fun of the British government. To be fair, they deserved it. They killed hundreds of kids in agonizing and preventable ways – they could take some ribbing. This is all throughout the mid-1980s to early-mid 1990s. Through this period, it wasn’t yet clear that mad cow could spread to humans. The panic was clear, and deserved, but it didn’t yet have a match for its powder keg. It would alight. The first suspected case of vCJD – human mad cow – was in 1994. Fifteen-year-old Vicky Rimmer developed a sudden, strange disease. Doctors gave her months to live...until she died in 1998. A couple other suspected cases trickled down through the mid-90s, including a young man who made meat pies for a living, whose grieving mother received a letter from the Prime Minister that “humans do NOT get mad cow disease”. (That must’ve been fun.) Soon, they couldn’t deny it any longer. On March 20, 1996, Stephen Dorrell, the health secretary, stood up in Parliament to announce the news that had already appeared as a tentative conclusion in scientific journals and as rumor in newspapers for the previous two years: British beef was killing British teenagers. The first confirmed death was that of Stephen Churchill, a nineteen-year-old student from Wiltshire, who died in May 1995. Back in 1989, at the Southwood Working Party’s suggestion, the government had set up a surveillance unit in Edinburgh to watch for any evidence that BSE had crossed to humans. One worry had been that if BSE passed to humans, how would anyone know it? How would you recognize something you had never seen? It turned out to be easy: Churchill and the nine other teenagers who had gotten sick had spectacular amyloid plaques in their brains, chunks of dead protein almost visible to the naked eye. If sporadic CJD was a whisper, BSE-caused prion disease was a shout. The investigators sat open-mouthed looking at slides whose damage, they feared, portended the most severe epidemic in modern British history. This part of the book is not fun. It lacks the insane personalities and duelling careers of the other entries. It is an honest chronology of the vCJD epidemic – a gruesome failure of the agricultural industry, the one system that everyone is vulnerable to. The government and industry had completely violated their duty of care to citizens and consumers. They were paying the price. No one would buy British beef anymore – not while they watched their children die. Now here’s the thing: this is ethnography, not historiography. The Family That Couldn’t Sleep is a book from the mid-2000s. The epidemic was not at all in the rear view mirror. There were piles of unanswered questions that DTM constantly alludes to. We have eighteen years more hindsight than he did then. What do we know now? --------------------------------------------------------- In 2006, the vCJD epidemic looked like it was going to be a lot better than the worst fears. BSE itself was a huge problem for the cattle industry, but honestly, no one is too sympathetic to the cattle industry. People were not going to die in anywhere near the numbers believed. We had all sorts of reassuring data coming out about this, which DTM chronicles. We were learning that only some genotypes seemed susceptible to vCJD. We didn’t see any older people die of the disease. We were seeing numbers drop, such that vCJD must have a pretty short incubation period. Anyway, all of this is wrong! The Family That Couldn’t Sleep was written in the candidate gene era. Back then, the nascent field of human genetics was sure it was about to Solve Polygenism. Yes, the simple Mendelian monogenic patterns popular a few decades back clearly didn’t apply to common diseases, but how many variants could there be? We were about to discover the five genes influencing 20% of Alzheimer’s risk each, the five genes influencing 20% of heart disease risk each, etc., and once we were done we’d just do gene therapy and cure Alzheimer’s. A paper on autism genetics from 1999 was so outre as to speculate there might be as many as fifteen genes involved. The fact we are now using the term “omnigenic model” should tell you roughly how well this worked out. Do you remember SNPedia? If you were a 2014 Slate Star Codex reader, you might. 2014 was still pretty candidate gene. People were out there publishing papers saying a single variant could increase your life expectancy by 15 years. SNPedia was a site that beautifully categorized all of these, so you could do 23andme or whatever, look up your results on SNPedia, and make horrible life choices.5 It was eventually bought out by one of the consumer DNA companies, so no one ever edited it again, making it a great time capsule of early-mid 2010s behavioural/medical genetics takes. SNPedia will excitedly explain to you that common genetic variants make you immune to vCJD. They cite a 2009 post from the now-archived 23andme blog titled “No Good Evidence That Potential Pool of Mad Cow Disease Victims Is Expanding”, explaining how fears of late-onset vCJD are clearly debunked by new Scientific Knowledge. Everyone who developed vCJD in the 1990s and 2000s had an M/M genotype in a particular part of the PRNP prion gene, so the roughly half the population with M/V or V/V genotypes were immune. The Family That Couldn’t Sleep buys this, too. In fact, it buys it in an even more agonizingly 2000s way. The first sign that transmissible prion diseases weren’t genotype-restricted should’ve been the growth hormone kids. You might have heard this story – from the late 1950s through mid-1980s, human growth hormone produced from brain tissue was used as a treatment for pituitary dwarfism, until it turned out to spread CJD if the originating brain was infected. DTM discusses this, to set the scene for the genetics thing. He mentions what was the state of the art at the time – that a disproportionate share of both the growth hormone kids and sporadic CJD cases were V/V homozygotes. This, uh – so the book was written in the mid-2000s, yeah? Yeah. The conclusion DTM drew – and this was a common conclusion at the time – was that homozygosity somehow made you more vulnerable to CJD, and M/M homozygosity made you vulnerable to BSE-borne CJD in particular. We cannot criticise the author for not predicting the future, but we live in the future, and can say how this worked out. Turns out, nope, M/V heterozygotes totally get vCJD. After a British man in his 30s died of CJD in 2016, he was found to have vCJD and an M/V genotype. He was tested for vCJD only because he was exceptionally young for someone with a sporadic prion disease – meaning people developing it later in life would be missed6. Did you know up to 1 in 2000 people in the UK have latent vCJD? There is one line in The Family That Couldn’t Sleep that stopped me dead in my tracks when I read it: What happens to the Italian family in the end depends less on their own actions than on the world’s interest in prion diseases, which they cannot control. If lots of people are afraid of getting variant CJD, the family benefits. If fear of prion disease goes the way of the fear of swine flu or Ebola, then they will be orphaned again. THIS BOOK IS FROM 2006! Three years before the swine flu pandemic! Eight years before the Ebola pandemic! “If you’re looking for a sign, this is it.” --------------------------------------------------------- The last section of The Family That Couldn’t Sleep addresses BSE fears in America and a nascent internet subculture DTM calls “Creutzfeldt Jakobins” – people who track American CJD cases, trying to spot vCJD patterns. When reading his description of the Creutzfeldt Jakobins, my mind constantly, uncontrollably turned to covid. Here it was – an online community of people deeply skeptical about a disease’s official story, tracking every contradiction, every implausibility, every statistic that failed to apply to the individual. Self-described “redneck hippies” and “soccer mom Republicans” teaming up to find the truth hidden behind an impossible world. You know what they’re doing now. I’ve always combined a deep interest in medicine with a healthy distrust for it. People who are constitutionally inquisitive, anti-authoritarian, and suspicious about official narratives tend to end up skeptical of at least some mainstream claims in the field. This is not to say I think you should take bleach enemas or something, just that I understand the impulse behind concluding the US government was covering up a local vCJD wave. Traditionally, sporadic prion diseases are said to have a prevalence of one in a million. (Hold on to that for a second.) The last section of the book is a chronology of Americans finding bizarrely more than one in a million of their friends dying of sporadic CJD, often at inexplicably young ages, sometimes in geographical clusters. This is understandably suspicious. Then DTM goes on to reassure us by saying none of these cases were confirmed to have an M/M genotype, which OH GOD OH FUCK A number of high-profile people in the prion world, including Gajdusek, are clarified as not believing sporadic prion diseases exist. You get the impression DTM doesn’t, either. Now, how common are prion diseases? Eric Vallabh Minikel has an answer for you! Eric and his wife Sonia are prion researchers from a rather unique background – after Sonia was diagnosed as having a single-gene mutation with ~100% penetrance for prion disease, they left their previous jobs to dedicate their lives to curing it. It turns out, when you run the numbers, you get not one in a million but 1 in 5000 people dying of prion diseases. This is best described as “nightmarishly high”. I’m normed on genetic disorders. A genetic disorder that affects one in five thousand people is pretty common! I have known, in person, completely unselected, just from “random people I’ve met in my life in a non-medical context”, someone with a ~1/250k syndrome and someone with a ~1/50k-100k syndrome. I don’t think anyone in my extended family knows someone who died of a prion disease. I feel like it would’ve come up if they did! Prion diseases have distinctive phenotypes. Not distinctive enough, apparently, to avoid a lot of CJD being misdiagnosed as Alzheimer’s – but diagnosis is consistently insane. Something DTM reiterates throughout The Family That Couldn’t Sleep is just what prion dementia looks like. The characteristic dementia in prion diseases spares something – “self” or “recognition” or “reflection” – that is not spared by Alzheimer’s, or by most common dementias. Shouldn’t this be, uh, noticeable?7 They kill rapidly, often over the course of months, and often onset in midlife. ALS shares this pattern and is way, way more common than prion diseases; you hear about ALS far more in the “disorder people actually have” sense. What am I missing here? Anyway: 1 in 2000 prevalence of latent vCJD in the UK + extreme lack of clarity over whether scrapie is human-transmissible + blood donations spread vCJD + sporadic CJD prevalence keeps going up = ??? (Yes, I am annoyed that most countries have lifted their ban on UK blood donors, thank you for asking!) --------------------------------------------------------- But back to the book. The “American chapter” is one-third about the country’s response to vCJD, one-third about the Creutzfeldt Jakobins, and one-third about chronic wasting disease. The last part is the most interesting. Chronic wasting disease is a prion disease of deer. Like scrapie, it “probably, we hope” isn’t human-transmissible (eat venison at your own risk). Under natural circumstances, deer shouldn’t get prion diseases: A prion plague should not be possible among ruminants in the wild. Deer are not cannibals, as the cows that spread BSE were forced to be; and, because deer and elk are not domesticated, they do not have enough contact with one another to spread a prion infection the way sheep are thought to spread scrapie. But deer do not live as they used to live, humans having once again brought their ambitions to bear on the natural course of things. The Family That Couldn’t Sleep is a book of medical anthropology. Anthropology of the Veneto, anthropology of Papua New Guinea, anthropology of 1990s Britain. Here, it is an anthropology of America. Americans, having won the world, still fight to win their own backyard. The North American continent is geographically diverse, cutting through rain-snow-shine, mountains jutting over plains, cities sprawling into wilderness, habitations criss-cross dotted with surprisingly few empty zones. Go somewhere like Denver, the Mile High City, three million people fighting against nature. Few other countries have anything like this; geographically vast polities usually have uninhabitable blocks. Australians are twenty-five million people clustered against the shore. It still surprises me, after all this time, how every US state has a meaningful city8. Midcentury Denver, growing and sprawling out across its mountains, started to run into their natural inhabitants – deer. Starvation is one way nature adjusts the deer population to the available food supply. People did not usually see this process, but in the 1950s and 1960s Colorado became more densely settled, reducing forested areas and forcing deer to look longer and harder for food. At the same time, the state enacted conservation laws, limiting when and where hunters could shoot. Soon emaciated deer began wandering onto the lawns and through suburban streets looking for a meal. People began to feed them, only to find that they died anyway. They would drop dead by haystacks, along highways, and in flower beds. In the late 1960s, a young biologist named Gene Schoonveld tried to figure out why the deer starved even when they were fed.9 He deprived some deer of food for a while, “[h]e cut windows in their stomachs to see what went on inside, and then he began to feed them”. While this was going on, he had a control group of healthy, well-fed deer as backups in case anything went wrong. It did...but not to the experimental group. The pen in which the deer were kept also housed sheep, which, it turned out, were scrapie carriers. The deer somehow acquired scrapie – there’s a huge unanswered question here, which DTM doesn’t address. How did they get scrapie? They didn’t eat the sheep, presumably. Did it somehow transmit from casual contact? This is not supposed to happen. And yet: the deer in the sheep pen started dying of a mysterious scrapie-like disease, one never reported before, that would go on to infect thousands. These deer were released into the wild. Ten years later, the first reports of chronic wasting disease came out. The disease spread across deer and elk in the western half of the country. By the turn of the millennium, cases were exploding – and lost all geographical restriction. DTM can report up to 2005, at which point it was floating around Upstate New York. This kind of spread doesn’t track natural deer migration. That’s irrelevant, because nothing about CWD’s spread is natural. We shift gears into an anthropology of the American hunter. The hunter wants to shoot the most impressive buck, to bag himself one with as many “points” as possible – one whose antlers branch out most. A “ten-point buck” has five branches on each horn: Original by Ric McArthur Nature doesn’t make enough bucks with perfectly symmetrical ten-point horns. To fill the demand, the market had to step in. Thus was born the deer farm industry, which raises captive deer in better genetic and nutritional conditions than Nature permits, then ships them across the country so hunters who couldn’t get legit ten-point bucks get the taxidermy piece for their wall. These are controversial amongst hunters and illegal in numerous states – but the industry is big enough to spread CWD. (The kind of hunter who needs a deer shipped to his house is the kind of hunter who will fumble killing it.) Another problem is supplemental feeding – leaving out protein-enriched food for deer to eat. This produces “trophy class animals at an earlier age”, but again, what’s in that protein? (“It is much like feeding your cows 41 percent protein cottonseed cake during the winter to raise the protein level in the cow’s diet to a level that will maintain acceptable production”, says that article from 1991.)10 The book segues into a vignette. CWD was new in Wisconsin in the early 2000s, and the state’s Department of Natural Resources was optimistic it could eradicate it. In a state with a love of hunting, you could, in theory, recruit people to kill every single deer in a 400-square-mile radius: In many states, the state would have had to call out the National Guard for such an onslaught, but hunting is a passion in Wisconsin. Hunters shoot 450,000 deer every year, more than in any other state. “I’m looking for ardent hunters to help us, unless fear or their wives keep them away,” one DNR official told a Milwaukee magazine. The state extended the normal hunting season and waived the usual limit of one buck per hunter, and the hunters came out in force. The whole affair was gruesome – one official called it “hunting for slob hunters”. If you’re trying to eradicate a prion disease, you can’t very well let people take the carcasses home to eat. Bodies piled up in control stations, decomposition mingling with bleach. The 2002 hunt established a base rate of 2% for chronic wasting disease in Wisconsin deer, with the most affected areas getting up to 10%. Further hunts in 2003, 2004, and 2005 spread to wider and wider areas – and didn’t move the needle one bit. This is to say that CWD is quite a bit more common in the American deer population than BSE ever was in British cattle. Since publication, it’s popped up in Norway and South Korea. Notably, Norway doesn’t allow for the import of cervids, raising numerous questions about how it got there. There are no unambiguous cases of CWD transmission to humans, and in vivo/in vitro primate studies have mixed results. There sure are some unusually young hunters with sporadic CJD, though. But don’t worry, most of them aren’t M/M homozygotes! There is an absolute ton going on in this book. I’ve had to skim over whole sections. Parts that couldn’t be easily slotted into a narrative review include: When Gajdusek was invited to a party at Prusiner’s house, he was horrified to find his rival had purchased hundreds of New Guinean statues – all with the genitals removed.
Inline links: 2, Lyttle Lytton, 3, 4, a couple years later, concerningly transmissible to primates, omnigenic model, you might, 5, SNPedia, a 2009 post, https://substackcdn.com/image/fetch/$s_!N93S!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fced2eca3-ec58-40b8-8c13-debdb559ab8f_651x601.png, Yeah., nope, M/V heterozygotes totally get vCJD, 6, up to 1 in 2000 people in the UK have latent vCJD, bleach enemas, has an answer for you, 7, blood donations spread vCJD, going, up, 8, 9, not supposed to happen, https://substackcdn.com/image/fetch/$s_!0J8B!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F2a64b287-a7c6-4d82-bbe1-da949fc93118_1024x683.png, Ric McArthur, controversial, amongst, hunters, illegal in numerous states, trophy class animals at an earlier age, 10, Norway, South Korea, mixed results, sure are
In 1862, Louis Pasteur boiled broth to kill the microscopic life in it, put some of the liquid in a goose-necked flask, and showed that if nothing living ever reached the liquid, no life would ever grow there. The experiment had enormous practical impact; it gave doctors the knowledge they still use to save lives by showing that because infections were living, reproducing things, if you could keep an environment sterile, you could keep a patient healthy. Had infectious prions been in Pasteur’s flask, curative medicine would never have gotten started. Doctors would still be competing with shamans and medicasters.
Perhaps prion research owes its existence to a similar fluke. Prions are recognizably genetic-infectious-sporadic in a sense untrue of most diseases. But the mainstream take on prion infection is that it’s actually pretty tricky – animal prion research involves injecting the proteins directly into the brain, because anything else won’t work well enough. If we had tried harder to shoot prisoners full of cancer in the 1950s, would it have scooped the recognition of prions? What if Alzheimer’s became a significant research area decades before it did in our world? (Maybe if a 1920s starlet rather than a 1940s one had an early-onset case.) It’s possible prions could never have been recognized as “unique”. We might still be running in circles with scrapie. We might – just might – have had a much bigger problem with BSE.
Inline links: shoot prisoners full of cancer, a 1940s one
prion diseases1 mentions across 1 issues

prion diseases is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between July 12, 2024 and July 12, 2024. The archive places it in contexts such as "The problem, as DTM explains, is that prion diseases were impossible"; "how common are prion diseases? ...sporadic prion diseases... genetic disorder"; "5000 people dying of prion diseases". It most often appears alongside 1980s, 1989, 1990s.

Reference entry
prion diseases
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1
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1
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July 12, 2024
Last seen
July 12, 2024
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Your Book Review: The Family That Couldn’t Sleep
July 12, 2024 · Original source
The numbers were down by this point; the fear of a mad cow pandemic seemed to flicker, then die. The dust was settling, as it were, and it was just now possible to write a history. Simultaneously, it was still in the spotlight. Prion diseases gripped people’s souls with fear. You couldn’t sell a book about mad cow so well ten years later; people were much less scared of it. “That thing people were panicking about in 1999? Wasn’t it a nothingburger?”
The Family That Couldn’t Sleep comes from this era of...optimism? Yeah, let’s say optimism. The wildest predictions – that hundreds of thousands of people across Britain would be struck by vCJD around the turn of the millennium – were clearly wrong. The disease was severe enough to strike the fear of prion diseases into people’s hearts; the name, entirely unfamiliar a few years earlier, now defines a bogeyman cluster of The Worst Diseases Possible. It seemed possible they could be human epidemics, if small ones. This was enough to be scary. But it wasn’t quite as scary as a Game Over.
A point about prion diseases that D. T. Max likes emphasizing is that they don’t steal your reason. Everyone was unanimous that across multiple prion diseases – fatal familial insomnia itself, but also many forms of Creutzfeldt-Jakob, and plenty of other things you could grant such a name – the afflicted were consistently aware of their fates, even in the worst reaches of the illness. Many people with FFI never lost the ability to talk at all, and could express this very well for themselves. Others did, but seemed to know their surroundings infaillibly. There is a famous case report about a man with FFI who managed to slow the disease’s progression with a slew of treatments; he could consistently describe his state in his most “incapacitated” periods when remitting. I’ll let him speak for himself:
Inline links: case report
prion-like spread1 mentions across 1 issues

prion-like spread is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between August 14, 2025 and August 14, 2025. The archive places it in contexts such as "prion-like spread of the misfolded proteins". It most often appears alongside A. Bejanin, A. de Calignon, A. Elobeid.

Reference entry
prion-like spread
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1
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1
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August 14, 2025
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August 14, 2025
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In Defense Of The Amyloid Hypothesis
August 14, 2025 · Original source
Overproduction or reduced clearance due to microbial infection. Amyloid-β appears to be an antimicrobial peptide and will form plaques in response to infection. [2, 3] This explains various observations that have been used to support the “infectious hypothesis”, sometimes proposed as an alternative to the amyloid hypothesis. However, it can only explain a subset of cases and, as I argue below, is even then still mediated by amyloid via an “IATN” pathway: infection → amyloid → tau → neurodegeneration. In cases of increased production, cerebrospinal fluid (CSF) will show elevated amyloid. In cases of reduced clearance, amyloid will decrease in CSF. In all cases, however, PET scans will show elevated brain amyloid, usually at first mainly in “intrinsic connectivity networks” such as the default mode network [14–20], which experience brain activity even at rest. These neurons are the most active - which causes more production and possibly less opportunity for clearance - so they tend to be the first to suffer from a production/clearance imbalance. Over time, amyloid pathology spreads spatially throughout the brain. [14, 18] Aggregations of amyloid peptides induce more such aggregations. Some of our clearest evidence for this comes from growth hormone deficiency patients, who used to have cadaver-derived ground-up brain matter injected into their own brains to provide the missing hormones. If the ground-up brain matter was sourced from the corpse of an Alzheimer’s patient, the growth hormone deficiency patients would themselves develop Alzheimer’s at a young age, probably through prion-like spread of the misfolded proteins. [21, 22] After ∼15 years of preclinical spread, the pathology eventually covers the whole brain. [14, 18] While some subtle cognitive impairment may occur during this time, it is usually not severe enough to be clinically detectable from amyloid alone. Indeed, in both humans [23–30] and mice [31–35], the severity of neurodegeneration and cognitive deficits is not a good spatiotemporal match for the severity of amyloid pathology (rather, it is a good match for the severity of tau pathology; see next section for more). These facts are often suggested as evidence against the amyloid hypothesis. However, amyloid is causally upstream of tau, as I will argue below. Therefore, the existence of cognitively normal individuals with amyloid pathology is expected in the ATN model - but typically only for a few decades, before progression to the next stage. 2: Tau pathology (T) and neurodegeneration (N) Tauopathies are a range of prion-like diseases involving the tau protein [36], whose usual function is to assist in stabilizing microtubule structure. In a tauopathy, the tau protein misfolds, and induces other, nearby tau proteins to misfold into the same shape. [37–46]. Injecting nothing but misfolded tau fibrils into a mouse brain can recruit the endogenously-produced mouse tau into this pathology, which spreads far beyond the injection site, causing neurodegeneration wherever it goes. [35, 47–59] There are at least eight distinct ways the tau protein can misfold in human disease [36], and over a dozen distinct human tauopathies, each involving a specific one of those misfoldings. These include chronic traumatic encephalopathy, Pick’s disease, corticobasal degeneration, progressive supranuclear palsy, and Alzheimer’s disease, with the last by far the most common. Each of these five diseases has its own distinct tau fold. Most normal human beings eventually develop some tau pathology in adulthood, originating probably in the locus coeruleus [60–62], which is part of the brainstem. By middle age, some amount has usually spread to the hippocampus and entorhinal cortex in the medial temporal lobe, regions responsible for episodic memory. This is called primary age-related tauopathy (PART) [63], and has its own tau fold which is distinct from most tauopathies, but the same as Alzheimer’s. [36, 64] Usually, its local severity is mild and it doesn’t spread much beyond those regions. But with sufficient amyloid pathology, this “normal” tau pathology tends to both locally worsen and spread through the rest of the brain [65], becoming the tau pathology of Alzheimer’s. Some genetic risk factors such as ApoE, in addition to affecting the clearance of amyloid-β, also increase the brain’s susceptibility to this A → T pathology conversion [66, 67]. But this is a matter of degree, as sufficient amyloid pathology seems to virtually guarantee the transition: Every 10-centiloid increase in amyloid pathology for a cognitively normal individual increases by 2.7x the probability of a PET scan detecting pathological levels of tau within five years [68]. The only known cases where patients with extremely high amyloid levels can go significant amounts of time without developing tau pathology are a few individuals with extremely rare protective genes, known only from a few case studies, e.g. [69]. Even in these instances, the individuals will eventually succumb to the tau phase, suffering neural atrophy and dementia. [70] After it forms, the tau pathology no longer appears to require amyloid’s assistance to keep spreading (although amyloid may still accelerate it). This probably explains why existing anti-amyloid therapies have been only ∼30% effective in test patients, who are usually late in the amyloid → tau progression even if early in having symptomatic disease. Neurodegeneration follows tau pathology extremely closely in time and space, in humans as well as basically all animal models, and cognitive impairments match the functions of the affected regions. There are rare reports of advanced tau pathology without cognitive decline, often in people with protective ApoE2 alleles [71], but even then, systematic analysis finds that actual density of tau inclusions is highly predictive of cognitive impairment, and that these exceptional cases usually involve widespread but locally sparse pathology [66]. The regional distribution of tau pathology explains why the first symptom of Alzheimer’s is typically impaired memory; the first cortical sites affected are usually in regions involved in memory formation. As the pathology spreads, further regions are affected, until eventually all cognitive functions are affected. As with most other aspects of the disease, the high-level picture seems relatively clear but the exact cellular and molecular pathways are not well understood (though may involve an assist from the innate immune system, especially microglia and astrocytes. [13, 35, 72]) Early Alzheimer mouse models were amyloid-only, with extremely heavy overproduction of Aβ, much more than required to recapitulate the human disease, and apparently enough to cause detectable cognitive dysfunction. However, normal mice do not get age-related tauopathy, so an amyloid-only mouse model - while useful for investigating certain questions - is not a full Alzheimer’s disease model. Combined amyloid+tau pathology mouse models, which are transgenically modified and/or injected with misfolded human tau fibrils, display the property that the presence of amyloid pathology induces the worsening and spreading of tau pathology. This is also observed in vitro in human cells. How do we know the amyloid causes the tau? Researchers have measured the correlation in many ways, from the spatiotemporal timeline (tau pathology only begins locally worsening and spreading outside the medial temporal lobe once amyloid reaches sufficient severity) [65], [98], to causal mediation modeling in the human disease [26], [99–101], to causal intervention using in vitro human cell studies [54, 102] and animal models [35, 55], [103 – 113]. But also, giving people drugs that reduce amyloid levels also decreases tau pathology. [78, 80, 82] (I’ve left out or merely alluded to much other complexity, involving the innate immune system, lipid processing, and detailed molecular and cellular mechanisms, preferring to focus on the parts of the story which are crucial to deciding the causal role of amyloid, and for which I am aware of a satisfactory account from the literature. But I don’t intend to leave the impression that the above is all there is to Alzheimer’s disease, or that all cases progress in the same exact way.) The mechanistic claims I make the following two claims about amyloid-β’s role in Alzheimer’s: Amyloid deposits are a necessary (i.e. but-for) cause in all instances of Alzheimer dementia. That is, if someone has PET or CSF positivity for amyloid and tau pathologies, and the tau pathology involves the Alzheimer tau fold and made its first cortical appearance in the medial temporal lobe, and then they developed medial temporal volume loss + amnestic mild cognitive impairment + later dementia, then counterfactually, early enough (probably ∼15 years before clinical presentation) causal intervention solely to remove the amyloid deposits would have prevented almost all tau pathology and symptoms.
Inline links: below, probably through prion-like spread of the misfolded proteins, 10-centiloid, have been, the presence of amyloid pathology induces the worsening and spreading of tau pathology
Prisma1 mentions across 1 issues

Prisma is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between October 24, 2022 and October 24, 2022. The archive places it in contexts such as "and ideally Next.js, Prisma, or tRPC". It most often appears alongside Astralcodexten Com, California bill that restricts use of rap lyrics as criminal evidence, FTX Future Fund Regranting program.

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Open Thread 247
October 24, 2022 · Original source
The impactmarkets.io team is developing version 2.0 of their platform. They are funded by the FTX Future Fund Regranting program, and have a limited budget to pay contractors. They are looking for developers that have experience with TypeScript and React (and ideally Next.js, Prisma, or tRPC) to contribute. It would be well-suited for devs that want to have a large EA-aligned impact in their free time. Pay is $0-50/hour, based on skill and volunteer interest. Book a call with them or join their Discord to learn more or apply.
Inline links: impactmarkets.io, Book a call, Discord
prisoner’s dilemma1 mentions across 1 issues

prisoner’s dilemma is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between May 06, 2021 and May 06, 2021. The archive places it in contexts such as "Attempting to outlaw useful tools is a classic prisoner’s dilemma". It most often appears alongside 320 AD, 476 AD, Africa.

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Your Book Review: Through The Eye Of A Needle
May 06, 2021 · Original source
I tried to put on my “rationalist hat” to analyze the different systems during this period. To understand inefficient equilibrium, it’s helpful to look at societies other than our own. The late Romans found themselves in many “inefficient equilibrium.” Brown doesn’t use rationalist terms, but I think he’d agree with the following statements. The most obvious is the employment of barbarian tribes in Roman civil wars and their free license to plunder. When a wannabe emperor invited barbarian tribes to fight for him, he weakened the Respublica. Once this new tool was added to the arsenal of elite power struggles, it was difficult if not impossible to take power without using it. Attempting to outlaw useful tools is a classic prisoner’s dilemma. The optimal strategy is usually to be the first one to defect and use the outlawed tool.
PRNP1 mentions across 1 issues

PRNP is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between July 12, 2024 and July 12, 2024. The archive places it in contexts such as "in a particular part of the PRNP prion gene". It most often appears alongside 1980s, 1989, 1990s.

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Your Book Review: The Family That Couldn’t Sleep
July 12, 2024 · Original source
(This report was, as it happens, published in the exact same month as The Family That Couldn’t Sleep.) DTM came to know the family well. He befriended them by way of two members of their younger generation, Lisi – a woman terrified by the shadow of the disease, and Ignazio – the doctor she had married, who was more terrified by the shadow of the disease. Ignazio put together the pieces of the family puzzle, consolidating all the disparate diagnoses into a single disorder and filling out a lot of blank spots on family trees. When DTM came along, he was able to help Ignazio make the case that the family would benefit from the spotlight – that greater awareness of FFI could lead to a cure both for them and for a slew of other prion diseases. As it so happens, he is one of those nonfiction authors who serve as a character in their own story. DTM has some form of progressive muscular palsy. He is, or at least was in 2006, not entirely sure what it is. The relatively unimpressive state of genetics at the time had not identified his causative mutation, though it looked a lot like one of the rarer forms of Charcot-Marie-Tooth disease2. DTM is pragmatic about this, the way everyone chronically ill is either pragmatic or doomed. Whatever he has, it is a defect in protein structure; his peripheral nerves decay not because of a problem with the nerves themselves but an inability of their scaffolding to hold them together, as he puts it. The last chapter of the book dwells on this, on the web of connections popping up between a thousand disorders. DTM’s disease is something vaguely similar, if you squint, to an exceptionally slow-progressing motor neurone disease; if you jump another level out, you see amyloid plaque diseases like Huntington’s and Alzheimer’s, and if you jump yet another level out, you see something like prions. His interest in the Venetian family was driven by this. Some of its members thought this a beautiful act of sympathy; others thought him a grotesque parody of themselves, an onlooker, a gawker, peddling their tragedy to salve his relatively insignificant problems. They are, he thinks, both right. That’s the beginning, and that’s the end. What happens in the middle? --------------------------------------------------------- The Venetian family lends the book its title, but they’re really more of a framing device. The Family That Couldn’t Sleep is separated into four parts, of which the first and fourth – the shortest by far – deal with the family. Part 2 is kuru, the king of fucked up diseases you read about in clickbait Weird Medicine listicles. Let’s talk about kuru! Kuru, is, famously, the prion disease you get if you eat another person’s brain. Well, not quite. It’s a prion disease that became endemic amongst women in the Fore society, who ritually ate brains, one of which had an inherited or spontaneous prion disease. This is an important note – there’s a tendency (which the book’s later chapters engage in) to assume cannibalism just has a Prion Disease Generator attached. If you eat people who don’t have prion diseases, you won’t suddenly get one. Uh, don’t eat people. Anyway, part 2 is DTM’s historiography of Fore-Westerner first contact. It’s hilarious. Papua New Guinea is a frankly ridiculous place; one of the all-time best Lyttle Lytton winners (worst first sentence from a hypothetical or, in this case, real work) was “Papua New Guinea is so violent that more than 820 languages are spoken there”. The native residents were so hostile to outsiders that all the colonial empires had cut their losses – and when you think about the places they colonized, that says something. After the First World War, PNG was ripped from its nominal German ‘owners’, but no one else wanted the place. So, of course, they gave it to the Australians. It was thirty years and another war before we actually made contact. 1940s Australia was as ‘settled’ as it’d ever be; the cities were bustling and the interior was mapped. The kind of explorer who two centuries before would be heading to new continents had to console himself with Pacific islands. Console he did. The native peoples of the PNG coasts were hostile enough to the wannabe-colonialists that the Australians, flying planes overhead, were the first people to discover that the island’s inland was populated too. No one had broken through on land. In all this deep and angry rainforest, the Fore were the furthest out. They lived far into the island’s mountainous interior; DTM describes their territory as “nearly vertical”. Calling people primitives is a bit passe these days for understandable reasons, but no other term comes to mind. The Fore had no name for themselves; we call them by an exonym, “the people to the south”. They weren’t, to be clear, hunter-gatherers – they were slash-and-burn agriculturalists, but very well-fed ones. Despite the tendency in grain-focused cultures for poor agriculturalists to be stunted/malnourished, the Fore were a remarkably healthy people. Well, except for the famous bit. The first remarkable thing about the Fore was just how quickly they wanted to assimilate. Most PNG tribes weren’t particularly enthused by Western offers of injections/tractors/radios/Christianity. Yet as soon as the Australians arrived, the Fore made ceasefires in their wars with other tribes, volunteered to help large-scale Australian projects on the coast, started planting and trading coffee, and enthusiastically participated in censuses. It’s the only first-contact narrative I’ve seen where the colonizers were concerned about how badly the other guys wanted to be colonized. The next was the one that got their names in the history books. Australian officials started to notice a remarkable lack of women in Fore camps. Some tribes sequestered their women, particularly when Westerners were around, so at first they thought nothing of it. The high rate of unpartnered young men, though, was way out of PNG norms. DTM tells this part fantastically. The Fore chapters drip with the dread of dramatic irony. When the first breakthrough comes, you have to catch your breath: “Tiny” Carey noted something in the middle of August 1950 that deepened this mystery. He noticed that near the village of Henganofi there had been an unusual number of deaths. “It appears,” he wrote his superiors, “natives suffer from stomach trouble, get violent shivering, as with the ague, and die fairly rapidly.” [...] McArthur investigated a little more [...] One day in August 1953 he ran into more of the shivering people Tiny Carey had seen several years before: “Nearing one of the dwellings, I observed a small girl sitting down beside a fire. She was shivering violently and her head was jerking spasmodically from side to side.” It would be quite some time before anyone figured out what caused it – but the problem, as DTM notes, was that its cause wasn’t possible. Everyone priored that the weird undescribed disease in the Fore lands was some nocebo sorcery-sickness. Vincent Zigas, the first actual doctor sent to work with the Fore, tried to placebo-effect them and failed miserably: On the way, Apekono stopped at a hut and showed Zigas his first kuru victim. “On the ground in the far corner sat a woman of about thirty,” the doctor wrote. “She looked odd, not ill, rather emaciated, looking up with blank eyes with a mask-like expression. There was an occasional fine tremor of her head and trunk, as if she were shivering from cold, though the day was very warm.” It was almost exactly the tableau McArthur had witnessed in 1953. Zigas, though, was a doctor. He could do more than look—or so he thought: “I decided I might as well try my own variety of magic,” he remembered. He rubbed Sloan’s Liniment, a balm for sore muscles, on her and declared to her family and his guide: “The sorcerer has put a bad spirit inside the woman. I am going to burn this spirit so that it comes out of her and leaves her. You will not see the fire, but she will feel it. The bad spirit will leave her and she will not die.” The lotion penetrated the woman’s skin and she writhed in pain. “Get up! Walk!” Zigas commanded theatrically. “The woman struggled feebly as if to rise, then, exhausted, started to tremble more violently, making a sound of foolish laughter, akin to a titter.” That evening Apekono asked Zigas not to try to cure any more kuru victims; “Don’t use your magic medicine anymore. It will not win our strong sorcery.” This was a disaster. The Fore were so cooperative precisely because they hoped “Western magic” could conquer theirs. As it became clear it couldn’t, they turned hostile. The Australians had hoped to “modernize a Stone Age people”; now all their subjects were dropping dead before their eyes, from what they could only assume was a “hysterical reaction” to colonization itself. So, to solve this, they needed a batshit insane American. Carleton Gajdusek is one of the characters who dominates The Family That Couldn’t Sleep. He couldn’t not. You could put him in a car commercial and he’d dominate it. Gajdusek was a physician with a rare, intense combination of science and practice. He was a romanticist, a field worker, and a lover of everything strange. He’d been an army doctor, a government conspiracy-cover-upper, and a postdoc under Linus Pauling who described his intent as “to straighten out Pauling’s ideas about proteins”. He hated civilization, in a slightly-to-Ted’s-centre sense, and was passionate about “primitives and isolates”. He jumped at the chance to work in Papua New Guinea; he planned to conduct a multi-site study on child development in such cultures, and relished the opportunity to live in a “primitive” environment himself. He did all this so he could rape kids. Oh, he did it for the scientific curiosity and love of medicine, but he also did it so he could rape kids. Gajdusek was a pedophile in the actual-lifelong-exclusive-paraphilia sense, as opposed to the “metonym for child molester” sense. Some people who roll snake-eyes on the Sexuality Dice repress it, but some are perfectly happy to act on it; Gajdusek was #2 in its fullest form, the kind of guy who believes that a well-lived life includes raping some kids. DTM doesn’t shy from this, not for a moment. It’s the first thing he tells you about Gajdusek. It couldn’t not be; you couldn’t talk about why he went to PNG otherwise. When Gajdusek landed in PNG, he first found the place too civilized. He’d been promised a land of “cannibal savages” – where were they? After some traipsing, he found them, right where he was promised. The Fore were perfect for Gajdusek. They had some kind of medical mystery that’d been lost on everyone else. They ate each other, in exactly the way he loved detailing in his diaries (“”Women and children, particularly, partake of the human flesh,” he noted with pleasure”). As kuru cases popped up, he aggressively recorded them. He wrote lovingly detailed notes that he sent back to his Australian advisor. He wrote with intensity, with exclamation marks, with the joie de vivre of a man just where he wanted to be. Gajdusek smothered the Fore with ‘cures’ that never worked, but they didn’t get angry at him. As DTM dryly puts it: “Their children trusted him, and that was enough for them.” At some point, someone suggested sending an anthropologist...or an epidemiologist...or literally anyone with more credentials than Gajdusek and Zigas3. Gajdusek threw a shitfit, convinced this one-and-a-half-man team was enough to Solve The Problem Forever. But he got bored eventually – running off with another tribe with, as his diary notes at length, an apparent custom of youths ritually fellating older men – and Zigas, I dunno, the book neglects him a bit here. So they managed to sneak in some anthropologists. The husband-and-wife team of Robert Glasse and Shirley Lindenbaum4 were the first involved parties to give a shit about the Fore as people, rather than as colonial subjects/medical mysteries/walking sex toys. What they uncovered was fascinating. The Fore were cannibals, yes, but they were recent cannibals. They didn’t have an ancient tradition of eating their dead, like the other visitors assumed. They happened to be in contact with some cannibal groups, and after a Fore man died of “sorcery”, they thought: well, what would happen if we ate him? “People tasting it expressed their approval. ‘”This is sweet,” they said, “What is the matter with us, are we mad? Here is good food and we have neglected to eat it.”” If not for the wild coincidence that the first Fore cannibalism victim had a prion disease, kuru would never have existed. Glasse and Lindenbaum started to put together the pieces. They’d been sent down to rule out a genetic explanation – to track the kinship ties of the Fore and see how the disease ran through families. It didn’t run through families in any coherent sense, but it sure did run through cannibalism. The clincher was the age distribution. The Fore, ever enthused by colonialism, quit eating each other as soon as the Australians arrived. Children stopped dying of kuru shortly after; they simply weren’t exposed to the infectious agent. The couple sent the news to Gajdusek, who was off raping kids somewhere else. In the next part of the book, DTM runs through Gajdusek’s many conjectures of kuru’s cause – more like sketches or abstract paintings than like true hypotheses. Gajdusek was annoyed that someone else was doing something he “totally could’ve done”, and even more annoyed that another lab was running similar experiments – an attempt at a vaccine for a particular sheep disease had accidentally created a prion generator. But he was happy to swoop in and claim the credit for what he was starting to think of as “slow viruses”, an infection that somehow lays dormant for years. DTM portrays Gajdusek perfectly, in that “real life has no need for verisimilitude” way. Gajdusek was at once a brilliant man, an all-consuming narcissist, an entertaining character, and a monster beyond redemption. A lesser book might pick one or two. The Family That Couldn’t Sleep portrays him as all four, and on a personality level (as opposed to a scientific one), the Gajdusek-focused parts are some of the most gripping. --------------------------------------------------------- Outside of the jumps between the Venetian family and everything else, The Family That Couldn’t Sleep is not siloed. The narratives of all prion diseases are deeply intertwined. This is what makes it a great book. It’s 300 pages of dramatic irony. You read the whole thing, waiting for the eureka moment – the point everyone realizes they’re looking at the same cause. It does, however, make it a tad difficult to review or synopsize. The book’s story is so weird – and, often, so at odds with conventional wisdom that trickles down about the Fore et al – that you have to recap quite a bit, and the book steadfastly resists recapping. The next couple chapters after we depart from Gajdusek’s credit-claiming are mostly about experiments with various prion diseases. They’re scientifically fascinating. Unlike some medical-books-for-general-audiences (cough, How Not to Study a Disease), DTM never talks down to the reader. He assumes someone reading a 300-page book about prions is smart and wants to learn about prions. He also has – you can feel it in his words – the agonizing experience of spending his life on the other side of the doctor’s desk, trying to beat into whoever he’s talking to that no, seriously, you don’t need to lie to him or try explain a complex disease at a fourth-grade level. The first prion disease studied was scrapie. Scrapie was a big deal – it starved and killed large shares of British sheep flocks, making it a serious economic problem. Veterinary researchers had tried to prevent or cure it for centuries. It was a veritable graveyard of ambitions: Quintessential was D. R. Wilson at the Moredun Institute in Scotland, who worked in the middle of the last century for more than a decade trying, with mounting frustration, to kill the scrapie agent. He found that it survived desiccation; dosing with chloroform, phenol, and formalin; ultraviolet light; and cooking at 100 degrees centigrade for thirty minutes. The scrapie researcher Alan Dickinson told me he remembered Wilson at the end of his career as “very, very, very quiet. Of course, that was after his breakdown.” “Now it is our turn to study prions. Perhaps we should approach the subject cautiously.” The problem, as DTM explains, is that prion diseases were impossible. They violated 20th-century understandings of biology. Proteins “were no more alive, and no more infectious, than bone”. Prion diseases seemed to have too many causes – genetic, infectious, and sporadic. They looked infection-like in some ways, but patients didn’t produce virus antibodies. Sheep exposed to scrapie, or chimps infected with kuru, took years to develop symptoms. Their facts did not fit together. In the 1960s, people started wondering. The unifying trait of prion agents was that they had to be denatured to be destroyed. Was this a particularly small virus defined by its protein coating? Or – even more outre – was it pure protein, no DNA at all? No one could figure out quite how the latter worked, but it was tempting. Gajdusek, by now a major figure in this field, kept a foot in both worlds. He didn’t want to stake his reputation on a no-DNA hypothesis, but he certainly sympathized. Enter Prusiner. Stanley Prusiner was Gajdusek’s counterpart. Where Gajdusek seemed permanently manic, Prusiner was deliberate and exacting. He entered Gajdusek’s “slow viruses” field in the early 1970s after a chance encounter with a CJD patient. He relished the laboratory in a way Gajdusek didn’t at all, and set out to optimize the hell out of his projects. Prusiner set out to isolate the smallest infectious particle in the scrapie agent. He injected tons of hamsters (hamsters got sick faster than mice) with increasingly tiny scrapie proteins, hoping to determine whether the Minimum Viable Scrapie was DNA. By the mid-1980s, he’d produced something so small it couldn’t possibly be a virus. Denaturing it destroyed it; exposing it to nucleic acid dissolvers actually made it stronger. Emboldened by this discovery, Prusiner set out to anoint himself the King of Prions. Here emerges something of a Voldemort-Umbridge distinction – the difference between cartoonish villainy and banal evil. Gajdusek is a bad guy because he rapes kids. Prusiner is a bad guy because he is the most grotesque stereotype of the Advisor/Peer Reviewer from Hell made flesh. Everything Prusiner did was to build his reputation atop a pile of skulls. When recruited as a peer reviewer for other prion papers, he wrote negative reviews to undermine their authors. He worked his grad students to the bone and intentionally destroyed their careers, telling them he’d “ruin them” if they entered prion research as competitors. He lied about the origin of the protein-only hypothesis, claiming he originated it a decade after it was actually conjectured. But hey, he was good at getting grants. I was surprised reading a lot of this, because for all the time I’ve been aware of it, the cause of prion disease has seemed settled. “Oh yeah, it’s a protein that gets all fucked up.” But DTM goes through just how unsettled it was right up through to The Family That Couldn’t Sleep’s publication. Serious confirmation only arrived a couple years later. Many people were deeply critical of the prion hypothesis – often, it seemed, because they loathed Prusiner too much to go along. Throughout the book, he cuts an uncharismatic figure. Gajdusek and Prusiner both won the Nobel for discovering prions, decades apart. This tells you something – the “discovery” of prions can be construed quite a few ways. Gajdusek formulated the hypothesis; Prusiner proved it. Gajdusek was grievously offended by Prusiner’s Nobel, perceiving his rival – not inaccurately – as a follower who never originated any ideas of his own. But Gajdusek was offended from a federal prison cell, so how’d that work out for him? Fascinating as all this is, no one published a book about prions in the mid-2000s because it was about kuru or FFI. They published books about prions because teenagers were dying, and people wanted to know why. DTM lays the seeds for part 3 – the mad cow section – in part 1. This is a discussion of scrapie, the longstanding prion disease of sheep. Scrapie was a medical mystery for centuries (remember poor D. R. Wilson), precisely because of the intuitive implausibility of prions. The scrapie chapter is a great history-of-science piece, covering the agricultural productivity revolutions of the 18th century, the surfeit of bizarre origins veterinarians concocted, and the treatments that never worked. Scrapie is not transmissible to humans – well, we hope. It’s concerningly transmissible to primates. But it’s been around for a long, long time, and it doesn’t epidemiologically look like humans get it...we hope. Anyway, you ever tried to generalize from one example? The British government did! In the mid-1980s, strange reports started coming out of the UK’s farms. Farmers were describing a new disease where dairy cows – incredibly docile creatures, under normal circumstances – turned hostile, kicking them as they went into the milking stalls. The symptoms looked to all the world like scrapie. Epidemiologists tracing the outbreaks found a unifying link with “cake” – animal protein feed sweetened with molasses. The scrapie-like symptoms must have traced to an infected sheep. But scrapie doesn’t transmit to humans, so it must be okay to keep slaughtering them, right? We all know how this ended. The best term for the British response to the mad cow outbreak is “cacklingly evil conspiracy”. The agricultural industry really, really didn’t need a huge zoonotic outbreak – so it decided it didn’t have one. They first suppressed all mentions that the disease looked like scrapie, then – when this became impossible – hyped up that scrapie doesn’t transmit to humans, so there’s nothing to worry about. The formal name of the disease, “bovine spongiform encephalopathy”, was supposedly chosen to optimize for unfamiliarity – it wouldn’t fit well in a headline. They emphasized, extensively, that there was nothing to worry about. Ever. At some point, people started asking questions. If there was nothing to worry about, why was the agricultural industry panicking so hard? As things became ever more worry-inducing, this turned down ludicrously twisting paths: Meanwhile, the Southwood Working Party and the experts who advised it were learning on the job. They learned, for instance, that the BSE agent entered the animal through the mouth and then followed the digestive tract into the organs that try to filter out infections—the tonsils, the guts, and the spleen—and from there traveled into the peripheral and central nervous system, and finally arrived at the brain. They also learned that pasties, meat pies, and even some baby foods contained tissues from a lot of those organs. So the Southwood Working Party recommended banning these organs, but only from baby food. This started a chain reaction of consumer doubt: if infected cow organs were unsafe for babies, how could they be good for adults? The government then banned offal, as the organs were collectively called, in all human food but gave the industry a grace period to get it out of the feed supply. Then pet food manufacturers began to wonder if what drove cows mad might not also drive dogs, cats, and parrots mad. The feed they sold came from concentrate made of the same sick animals that had previously made up the meat and bone meal farmers used. Their trade group decided to put a similar ban in place—immediately. So for five months it was safer to be a dog than a human in Britain. DTM spends pretty much this whole section of the book making fun of the British government. To be fair, they deserved it. They killed hundreds of kids in agonizing and preventable ways – they could take some ribbing. This is all throughout the mid-1980s to early-mid 1990s. Through this period, it wasn’t yet clear that mad cow could spread to humans. The panic was clear, and deserved, but it didn’t yet have a match for its powder keg. It would alight. The first suspected case of vCJD – human mad cow – was in 1994. Fifteen-year-old Vicky Rimmer developed a sudden, strange disease. Doctors gave her months to live...until she died in 1998. A couple other suspected cases trickled down through the mid-90s, including a young man who made meat pies for a living, whose grieving mother received a letter from the Prime Minister that “humans do NOT get mad cow disease”. (That must’ve been fun.) Soon, they couldn’t deny it any longer. On March 20, 1996, Stephen Dorrell, the health secretary, stood up in Parliament to announce the news that had already appeared as a tentative conclusion in scientific journals and as rumor in newspapers for the previous two years: British beef was killing British teenagers. The first confirmed death was that of Stephen Churchill, a nineteen-year-old student from Wiltshire, who died in May 1995. Back in 1989, at the Southwood Working Party’s suggestion, the government had set up a surveillance unit in Edinburgh to watch for any evidence that BSE had crossed to humans. One worry had been that if BSE passed to humans, how would anyone know it? How would you recognize something you had never seen? It turned out to be easy: Churchill and the nine other teenagers who had gotten sick had spectacular amyloid plaques in their brains, chunks of dead protein almost visible to the naked eye. If sporadic CJD was a whisper, BSE-caused prion disease was a shout. The investigators sat open-mouthed looking at slides whose damage, they feared, portended the most severe epidemic in modern British history. This part of the book is not fun. It lacks the insane personalities and duelling careers of the other entries. It is an honest chronology of the vCJD epidemic – a gruesome failure of the agricultural industry, the one system that everyone is vulnerable to. The government and industry had completely violated their duty of care to citizens and consumers. They were paying the price. No one would buy British beef anymore – not while they watched their children die. Now here’s the thing: this is ethnography, not historiography. The Family That Couldn’t Sleep is a book from the mid-2000s. The epidemic was not at all in the rear view mirror. There were piles of unanswered questions that DTM constantly alludes to. We have eighteen years more hindsight than he did then. What do we know now? --------------------------------------------------------- In 2006, the vCJD epidemic looked like it was going to be a lot better than the worst fears. BSE itself was a huge problem for the cattle industry, but honestly, no one is too sympathetic to the cattle industry. People were not going to die in anywhere near the numbers believed. We had all sorts of reassuring data coming out about this, which DTM chronicles. We were learning that only some genotypes seemed susceptible to vCJD. We didn’t see any older people die of the disease. We were seeing numbers drop, such that vCJD must have a pretty short incubation period. Anyway, all of this is wrong! The Family That Couldn’t Sleep was written in the candidate gene era. Back then, the nascent field of human genetics was sure it was about to Solve Polygenism. Yes, the simple Mendelian monogenic patterns popular a few decades back clearly didn’t apply to common diseases, but how many variants could there be? We were about to discover the five genes influencing 20% of Alzheimer’s risk each, the five genes influencing 20% of heart disease risk each, etc., and once we were done we’d just do gene therapy and cure Alzheimer’s. A paper on autism genetics from 1999 was so outre as to speculate there might be as many as fifteen genes involved. The fact we are now using the term “omnigenic model” should tell you roughly how well this worked out. Do you remember SNPedia? If you were a 2014 Slate Star Codex reader, you might. 2014 was still pretty candidate gene. People were out there publishing papers saying a single variant could increase your life expectancy by 15 years. SNPedia was a site that beautifully categorized all of these, so you could do 23andme or whatever, look up your results on SNPedia, and make horrible life choices.5 It was eventually bought out by one of the consumer DNA companies, so no one ever edited it again, making it a great time capsule of early-mid 2010s behavioural/medical genetics takes. SNPedia will excitedly explain to you that common genetic variants make you immune to vCJD. They cite a 2009 post from the now-archived 23andme blog titled “No Good Evidence That Potential Pool of Mad Cow Disease Victims Is Expanding”, explaining how fears of late-onset vCJD are clearly debunked by new Scientific Knowledge. Everyone who developed vCJD in the 1990s and 2000s had an M/M genotype in a particular part of the PRNP prion gene, so the roughly half the population with M/V or V/V genotypes were immune. The Family That Couldn’t Sleep buys this, too. In fact, it buys it in an even more agonizingly 2000s way. The first sign that transmissible prion diseases weren’t genotype-restricted should’ve been the growth hormone kids. You might have heard this story – from the late 1950s through mid-1980s, human growth hormone produced from brain tissue was used as a treatment for pituitary dwarfism, until it turned out to spread CJD if the originating brain was infected. DTM discusses this, to set the scene for the genetics thing. He mentions what was the state of the art at the time – that a disproportionate share of both the growth hormone kids and sporadic CJD cases were V/V homozygotes. This, uh – so the book was written in the mid-2000s, yeah? Yeah. The conclusion DTM drew – and this was a common conclusion at the time – was that homozygosity somehow made you more vulnerable to CJD, and M/M homozygosity made you vulnerable to BSE-borne CJD in particular. We cannot criticise the author for not predicting the future, but we live in the future, and can say how this worked out. Turns out, nope, M/V heterozygotes totally get vCJD. After a British man in his 30s died of CJD in 2016, he was found to have vCJD and an M/V genotype. He was tested for vCJD only because he was exceptionally young for someone with a sporadic prion disease – meaning people developing it later in life would be missed6. Did you know up to 1 in 2000 people in the UK have latent vCJD? There is one line in The Family That Couldn’t Sleep that stopped me dead in my tracks when I read it: What happens to the Italian family in the end depends less on their own actions than on the world’s interest in prion diseases, which they cannot control. If lots of people are afraid of getting variant CJD, the family benefits. If fear of prion disease goes the way of the fear of swine flu or Ebola, then they will be orphaned again. THIS BOOK IS FROM 2006! Three years before the swine flu pandemic! Eight years before the Ebola pandemic! “If you’re looking for a sign, this is it.” --------------------------------------------------------- The last section of The Family That Couldn’t Sleep addresses BSE fears in America and a nascent internet subculture DTM calls “Creutzfeldt Jakobins” – people who track American CJD cases, trying to spot vCJD patterns. When reading his description of the Creutzfeldt Jakobins, my mind constantly, uncontrollably turned to covid. Here it was – an online community of people deeply skeptical about a disease’s official story, tracking every contradiction, every implausibility, every statistic that failed to apply to the individual. Self-described “redneck hippies” and “soccer mom Republicans” teaming up to find the truth hidden behind an impossible world. You know what they’re doing now. I’ve always combined a deep interest in medicine with a healthy distrust for it. People who are constitutionally inquisitive, anti-authoritarian, and suspicious about official narratives tend to end up skeptical of at least some mainstream claims in the field. This is not to say I think you should take bleach enemas or something, just that I understand the impulse behind concluding the US government was covering up a local vCJD wave. Traditionally, sporadic prion diseases are said to have a prevalence of one in a million. (Hold on to that for a second.) The last section of the book is a chronology of Americans finding bizarrely more than one in a million of their friends dying of sporadic CJD, often at inexplicably young ages, sometimes in geographical clusters. This is understandably suspicious. Then DTM goes on to reassure us by saying none of these cases were confirmed to have an M/M genotype, which OH GOD OH FUCK A number of high-profile people in the prion world, including Gajdusek, are clarified as not believing sporadic prion diseases exist. You get the impression DTM doesn’t, either. Now, how common are prion diseases? Eric Vallabh Minikel has an answer for you! Eric and his wife Sonia are prion researchers from a rather unique background – after Sonia was diagnosed as having a single-gene mutation with ~100% penetrance for prion disease, they left their previous jobs to dedicate their lives to curing it. It turns out, when you run the numbers, you get not one in a million but 1 in 5000 people dying of prion diseases. This is best described as “nightmarishly high”. I’m normed on genetic disorders. A genetic disorder that affects one in five thousand people is pretty common! I have known, in person, completely unselected, just from “random people I’ve met in my life in a non-medical context”, someone with a ~1/250k syndrome and someone with a ~1/50k-100k syndrome. I don’t think anyone in my extended family knows someone who died of a prion disease. I feel like it would’ve come up if they did! Prion diseases have distinctive phenotypes. Not distinctive enough, apparently, to avoid a lot of CJD being misdiagnosed as Alzheimer’s – but diagnosis is consistently insane. Something DTM reiterates throughout The Family That Couldn’t Sleep is just what prion dementia looks like. The characteristic dementia in prion diseases spares something – “self” or “recognition” or “reflection” – that is not spared by Alzheimer’s, or by most common dementias. Shouldn’t this be, uh, noticeable?7 They kill rapidly, often over the course of months, and often onset in midlife. ALS shares this pattern and is way, way more common than prion diseases; you hear about ALS far more in the “disorder people actually have” sense. What am I missing here? Anyway: 1 in 2000 prevalence of latent vCJD in the UK + extreme lack of clarity over whether scrapie is human-transmissible + blood donations spread vCJD + sporadic CJD prevalence keeps going up = ??? (Yes, I am annoyed that most countries have lifted their ban on UK blood donors, thank you for asking!) --------------------------------------------------------- But back to the book. The “American chapter” is one-third about the country’s response to vCJD, one-third about the Creutzfeldt Jakobins, and one-third about chronic wasting disease. The last part is the most interesting. Chronic wasting disease is a prion disease of deer. Like scrapie, it “probably, we hope” isn’t human-transmissible (eat venison at your own risk). Under natural circumstances, deer shouldn’t get prion diseases: A prion plague should not be possible among ruminants in the wild. Deer are not cannibals, as the cows that spread BSE were forced to be; and, because deer and elk are not domesticated, they do not have enough contact with one another to spread a prion infection the way sheep are thought to spread scrapie. But deer do not live as they used to live, humans having once again brought their ambitions to bear on the natural course of things. The Family That Couldn’t Sleep is a book of medical anthropology. Anthropology of the Veneto, anthropology of Papua New Guinea, anthropology of 1990s Britain. Here, it is an anthropology of America. Americans, having won the world, still fight to win their own backyard. The North American continent is geographically diverse, cutting through rain-snow-shine, mountains jutting over plains, cities sprawling into wilderness, habitations criss-cross dotted with surprisingly few empty zones. Go somewhere like Denver, the Mile High City, three million people fighting against nature. Few other countries have anything like this; geographically vast polities usually have uninhabitable blocks. Australians are twenty-five million people clustered against the shore. It still surprises me, after all this time, how every US state has a meaningful city8. Midcentury Denver, growing and sprawling out across its mountains, started to run into their natural inhabitants – deer. Starvation is one way nature adjusts the deer population to the available food supply. People did not usually see this process, but in the 1950s and 1960s Colorado became more densely settled, reducing forested areas and forcing deer to look longer and harder for food. At the same time, the state enacted conservation laws, limiting when and where hunters could shoot. Soon emaciated deer began wandering onto the lawns and through suburban streets looking for a meal. People began to feed them, only to find that they died anyway. They would drop dead by haystacks, along highways, and in flower beds. In the late 1960s, a young biologist named Gene Schoonveld tried to figure out why the deer starved even when they were fed.9 He deprived some deer of food for a while, “[h]e cut windows in their stomachs to see what went on inside, and then he began to feed them”. While this was going on, he had a control group of healthy, well-fed deer as backups in case anything went wrong. It did...but not to the experimental group. The pen in which the deer were kept also housed sheep, which, it turned out, were scrapie carriers. The deer somehow acquired scrapie – there’s a huge unanswered question here, which DTM doesn’t address. How did they get scrapie? They didn’t eat the sheep, presumably. Did it somehow transmit from casual contact? This is not supposed to happen. And yet: the deer in the sheep pen started dying of a mysterious scrapie-like disease, one never reported before, that would go on to infect thousands. These deer were released into the wild. Ten years later, the first reports of chronic wasting disease came out. The disease spread across deer and elk in the western half of the country. By the turn of the millennium, cases were exploding – and lost all geographical restriction. DTM can report up to 2005, at which point it was floating around Upstate New York. This kind of spread doesn’t track natural deer migration. That’s irrelevant, because nothing about CWD’s spread is natural. We shift gears into an anthropology of the American hunter. The hunter wants to shoot the most impressive buck, to bag himself one with as many “points” as possible – one whose antlers branch out most. A “ten-point buck” has five branches on each horn: Original by Ric McArthur Nature doesn’t make enough bucks with perfectly symmetrical ten-point horns. To fill the demand, the market had to step in. Thus was born the deer farm industry, which raises captive deer in better genetic and nutritional conditions than Nature permits, then ships them across the country so hunters who couldn’t get legit ten-point bucks get the taxidermy piece for their wall. These are controversial amongst hunters and illegal in numerous states – but the industry is big enough to spread CWD. (The kind of hunter who needs a deer shipped to his house is the kind of hunter who will fumble killing it.) Another problem is supplemental feeding – leaving out protein-enriched food for deer to eat. This produces “trophy class animals at an earlier age”, but again, what’s in that protein? (“It is much like feeding your cows 41 percent protein cottonseed cake during the winter to raise the protein level in the cow’s diet to a level that will maintain acceptable production”, says that article from 1991.)10 The book segues into a vignette. CWD was new in Wisconsin in the early 2000s, and the state’s Department of Natural Resources was optimistic it could eradicate it. In a state with a love of hunting, you could, in theory, recruit people to kill every single deer in a 400-square-mile radius: In many states, the state would have had to call out the National Guard for such an onslaught, but hunting is a passion in Wisconsin. Hunters shoot 450,000 deer every year, more than in any other state. “I’m looking for ardent hunters to help us, unless fear or their wives keep them away,” one DNR official told a Milwaukee magazine. The state extended the normal hunting season and waived the usual limit of one buck per hunter, and the hunters came out in force. The whole affair was gruesome – one official called it “hunting for slob hunters”. If you’re trying to eradicate a prion disease, you can’t very well let people take the carcasses home to eat. Bodies piled up in control stations, decomposition mingling with bleach. The 2002 hunt established a base rate of 2% for chronic wasting disease in Wisconsin deer, with the most affected areas getting up to 10%. Further hunts in 2003, 2004, and 2005 spread to wider and wider areas – and didn’t move the needle one bit. This is to say that CWD is quite a bit more common in the American deer population than BSE ever was in British cattle. Since publication, it’s popped up in Norway and South Korea. Notably, Norway doesn’t allow for the import of cervids, raising numerous questions about how it got there. There are no unambiguous cases of CWD transmission to humans, and in vivo/in vitro primate studies have mixed results. There sure are some unusually young hunters with sporadic CJD, though. But don’t worry, most of them aren’t M/M homozygotes! There is an absolute ton going on in this book. I’ve had to skim over whole sections. Parts that couldn’t be easily slotted into a narrative review include: When Gajdusek was invited to a party at Prusiner’s house, he was horrified to find his rival had purchased hundreds of New Guinean statues – all with the genitals removed.
Inline links: 2, Lyttle Lytton, 3, 4, a couple years later, concerningly transmissible to primates, omnigenic model, you might, 5, SNPedia, a 2009 post, https://substackcdn.com/image/fetch/$s_!N93S!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fced2eca3-ec58-40b8-8c13-debdb559ab8f_651x601.png, Yeah., nope, M/V heterozygotes totally get vCJD, 6, up to 1 in 2000 people in the UK have latent vCJD, bleach enemas, has an answer for you, 7, blood donations spread vCJD, going, up, 8, 9, not supposed to happen, https://substackcdn.com/image/fetch/$s_!0J8B!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F2a64b287-a7c6-4d82-bbe1-da949fc93118_1024x683.png, Ric McArthur, controversial, amongst, hunters, illegal in numerous states, trophy class animals at an earlier age, 10, Norway, South Korea, mixed results, sure are
pro-choice1 mentions across 1 issues

pro-choice is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between February 23, 2024 and February 23, 2024. The archive places it in contexts such as "pro-choice people have even less of a case". It most often appears alongside Alabama, anti-abortion, IVF.

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pro-choice
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1
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1
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February 23, 2024
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February 23, 2024
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Who Does Polygenic Selection Help?
February 23, 2024 · Original source
And if the anti-abortionist doesn’t have much of a case here, pro-choice people have even less of a case. This is a non-injury to something they don’t even acknowledge as having rights anyway. It maps to cases where everyone agrees a good thing has been done, like asking pregnant women not to drink, or teaching high-risk men parenting skills. We call these “preventing fetal alcohol syndrome” and “preventing child abuse”, and it’s equally fair to call polygenic selection “preventing schizophrenia”.
pro-choice organization1 mentions across 1 issues

pro-choice organization is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between August 19, 2022 and August 19, 2022. The archive places it in contexts such as "you can found your own pro-choice organization and (if it’s good enough) displace Planned Parenthood". It most often appears alongside 00s, 70s, 80s.

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1
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1
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August 19, 2022
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August 19, 2022
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Highlights From The Comments On Subcultures
August 19, 2022 · Original source
I had used the example of Planned Parenthood, which has a board of directors and strong institutional tradition so you can’t just waltz in and take it over. It sounds like the difference between this and what Anon’s proposing is that you can found your own pro-choice organization and (if it’s good enough) displace Planned Parenthood as the center of the pro-choice movement. I think this system - exit over voice, market selection, whatever you want to call it - is usually an improvement on pure authoritarianism.
pro-lab-leak1 mentions across 1 issues

pro-lab-leak is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between May 13, 2024 and May 13, 2024. The archive places it in contexts such as "I’m imagining a pro-lab-leak client saying". It most often appears alongside 17 CFR Part 40, 2024 election, Austin.

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pro-lab-leak
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1
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1
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May 13, 2024
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May 13, 2024
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  • 24 May 13, 2024
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24
May 13, 2024 · Original source
People changed their minds a little over time, but not in a very consistent way that mattered much in the end. What was the “client feedback”? The report says: Client feedback was provided to the Superforecasters on December 21. The client posed questions to the Superforecasters about their assessments up to that date and asked for their reactions to several studies and articles. In the days following the client engagement, the Superforecasters lowered their confidence in the natural zoonosis hypothesis from 73% to 67%, although zoonosis remained the most likely potential cause in their assessment. But following an active engagement with recent genomic studies and historical base rates of zoonotic spillovers, those numbers began to return to earlier levels. January also saw increased attention to the geopolitical context and transparency issues, particularly related to research activities in Wuhan Is this bad? I’m imagining a pro-lab-leak client saying “But what about [this list of pro-lab-leak arguments]?” and then the superforecasters read them and adjust. In one sense, it’s good that they got to see more arguments; on the other, it seems like a potential route by which clients could bias the results - probabilities never quite got back to where they were before the feedback, though they got pretty close. The last-minute spike for zoonosis might be the Rootclaim debate results, which were released on 2/18. So maybe the client feedback and the Rootclaim results both slightly affected the numbers, but mostly the superforecasters started out pro-zoonosis and stuck to their guns. Dan Schwarz and the FutureSearch team say that forecasting has a “rationale-shaped hole”. Despite the report making this sound like a pretty intense process, we don’t get much information about details: In their extensive discussions , Good Judgment’s Superforecasters assessed base rates and historical patterns, existing evidence and scientific analysis, geopolitical context and transparency concerns, trust in intelligence communities, and methodological constraints. 1. Base Rates and Historical Patterns: The Superforecasters frequently referenced base rates, i.e., the history of pandemics emerging from natural zoonosis versus the history of laboratory leaks, to anchor their probabilities. For the former, they discussed how the base rates are changing as the climate warms and as expanding human populations push farther into natural environments that previously saw little human presence. For the latter, they acknowledged that it has only been 12 years since the advent of CRISPR gene- editing tools, and the base rate of lab leaks in the short synthetic biology era is not yet well established. 2. New Evidence and Scientific Analysis: Throughout the period, the Superforecasters adapted their forecasts in light of new scientific evidence, including genomic analyses of SARS-CoV-2 and its relation to bat viruses, and the debate over potential laboratory manipulation. 3. Geopolitical Context and Transparency Concerns: The geopolitical implications of the virus’s origins, particularly in relation to China’s transparency and the involvement of international research institutions, played a significant role in the analysis. Concerns over data veracity, and over the political ramifications of determining that the pandemic’s origins were other than zoonosis, were extensively debated. 4. Trust in Intelligence: Commentary on trust in intelligence communities and discussions about the impact of geopolitical biases on the interpretation of evidence illustrated the complex interplay between science, politics, and human behavior in assessing the pandemic’s origins. 5. Methodological Critiques and the Evaluation of Evidence: The Superforecasters engaged in methodological critiques of the evidence base, including the scrutiny of laboratory practices and biocontainment levels [...] In the end, most Superforecasters were in rough agreement on issues like the base rates of zoonotic spillover. Where they most often disagreed was on the interpretation of actions by Chinese officials and whether their actions reflected how an authoritarian government would react in any crisis over which it did not have full control, or whether those actions were indicative of attempts to cover up a biomedical research-related accident that allowed the SARS-CoV-2 virus to enter circulation in China and, ultimately, the entire globe. Probably it would be too much to ask for to get a transcript of all their discussions - then they’d be nervous saying things that might make them look bad to an audience. What would be a good balance between getting more information and not imposing on their time? Forecasting is an unusually legible and easy-to-judge domain. One of the theories of change for forecasting was to use it to identify smart people with good reasoning, then turn them loose on less well-behaved problems. This is one of the first big attempts to do this at scale. How did it work? We can’t tell, because it’s inherently an illegible and hard-to-judge domain. Darn. I don’t know what I expected. Notes From A Local Optimum Austin’s concern - that forecasting has reached a local optimum - is widely shared. We have some good sites: Manifold, Metaculus, Polymarket, GJO, etc - all doing good work. We have good-ish probabilities for a few important questions. Every so often a news source cites them. Sometimes a decision-maker looks at them behind the scenes, maybe. Is this all there is? The FutureSearch team says the next step is to focus on “rationale”. We need to use forecasting not just to get a raw probability, but to explain what’s going on and why we think something. Then instead of just convincing policy-makers to trust forecasts, we can tell them why something is true, or inform their discussions even if they’re not willing to blindly trust a number. Is this a betrayal of the forecasting ethos? The original dream was that instead of a bunch of people giving arguments, we could just test who was right. Now we’re going back to the arguments? People have argued forever; what does forecasting add to that? Well, they add the knowledge that the arguments are from people who have been right a lot before and are incentivized to be right again. Still, it’s not a natural fit. Probably it’s relevant here that FutureSearch’s forecasting AI does a really good job of this by default, in a way humans can’t match. Nuno’s yearly forecasting roundup doesn’t have a single thesis, but the first part is a well-supported complaint that most forecasting sites aren’t good business. They either burn VC money, burn EA donations, or converge towards casinos to support themselves. He gives an honorable exception to Cultivate Labs, which sells prediction market software rather than the results themselves. Open Philanthropy (billionaire Dustin Moskovitz’s EA-aligned charitable foundation) has at least given forecasting a vote of confidence, recently choosing to promote it to one of their main donation areas. Still, they got a lot of pushback on the decision, for example SuperDuperForecasting here: This will be a total waste of time and money unless OpenPhil actually pushes the people it funds towards achieving real-world impact. The typical pattern in the past has been to launch yet another forecasting tournament to try to find better forecasts and forecasters. No one cares, we already know how to do this since at least 2012! The unsolved problem is translating the research into real-world impact. Does the Forecasting Research Institute have any actual commercial paying clients? What is Metaculus's revenue from actual clients rather than grants? Who are they working with and where is the evidence that they are helping high-stakes decision makers improve their thought processes? Incidentally, I note that forecasting is not actually successful even within EA at changing anything: superforecasters are generally far more relaxed about Xrisk than the median EA, but has this made any kind of difference to how EA spends its money? It seems very unlikely. And Marcus Abramovich here: I'm in the process of writing up my thoughts on forecasting in general and particularly EA's reverence for forecasting but I feel, similar to @Grayden that forecasting is a game that is nearly perfectly designed to distract EAs from useful things. It's a combination of winning, being right when others are wrong and seemingly useful, all wrapped into a fun game. I'd like to see tangible benefits to more broad funding of forecasting that seems to be done in t he millions and tens of millions of dollars. I would also be the type of person you would think would be a greater fan of forecasting. I'm the number one forecaster on Manifold and I've made tens of thousands of dollars on Polymarket. But I think we should start to think of forecasting as more of a game that EAs like to play, something like Magic the Gathering that is fun and has some relations to useful things but isn't really useful by itself. Eli Lifland has a long and hard-to-summarize comment here, response from Ozzie Gooen here, podcast between them on “Is Forecasting A Promising EA Cause Area?” here. I’m split on this. My previous hope was that the field would gradually grow, without any qualitative changes or discontinuities, until it became big enough that journalists and policy-makers were aware of it and took it seriously (compare eg the growth of the Internet as a scholarly resource). I think the strongest argument against this is Manifold’s relatively flat user numbers. Is there a new hope? I think if nothing else, forecasting might be useful as a testing ground: First, to create forecasting AIs (like FutureSearch) which can then get consulted on a variety of questions, eg by policy-makers. The biggest holdup has always been the need to gather 20 or 50 or however many hard-to-find superforecasters for whatever question you’re asking, and then trust their advice even though they’re fallible fleshbag humans. If you can use the 20 to 50 superforecasters to inspire an AI, and then test the AI and prove it’s good, people might be more interested. This is especially true if the AI can branch out beyond traditional forecasting questions. Once we have a few of these, we can start comparing the next generation of AIs to the previous generation, and skip the superforecasters.
Inline links: forecasting has a “rationale-shaped hole”, Nuno’s yearly forecasting roundup, Cultivate Labs, choosing to promote it to one of their main donation areas, here, superforecasters are generally far more relaxed about Xrisk, here, @Grayden, here, here, “Is Forecasting A Promising EA Cause Area?” here
pro-life movement1 mentions across 1 issues

pro-life movement is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between February 20, 2023 and February 20, 2023. The archive places it in contexts such as "no more controversial than the gun lobby or the pro-life movement". It most often appears alongside 2020 election, 2020 primary, 23andme.

Reference entry
pro-life movement
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1
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1
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February 20, 2023
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February 20, 2023
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Grading My 2018 Predictions For 2023
February 20, 2023 · Original source
The culture wars will continue to be marked by both sides scoring an unrelenting series of own-goals, with the victory going to whoever can make their supporters shut up first. The best case scenario for the Right is that Jordan Peterson’s ability to not instantly get ostracized and destroyed signals a new era of basically decent people being able to speak out against social justice; this launches a cascade of people doing so, and the vague group consisting of Jordan Peterson, Sam Harris, Steven Pinker, Jonathan Haidt, etc coalesces into a perfectly respectable force no more controversial than the gun lobby or the pro-life movement or something. With social justice no longer able to enforce its own sacredness values against blasphemy, it loses a lot of credibility and ends up no more powerful or religion-like than eg Christianity. The best case scenario for the Left is that the alt-right makes some more noise, the media is able to relentlessly keep everyone’s focus on the alt-right, the words ALT-RIGHT get seared into the public consciousness every single day on every single news website, and everyone is so afraid of being associated with the alt-right that they shut up about any disagreements with the consensus they might have. I predict both of these will happen, but the Right’s win-scenario will come together faster and they will score a minor victory.
Probabilistic Risk Assessment1 mentions across 1 issues

Probabilistic Risk Assessment is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between July 01, 2023 and July 01, 2023. The archive places it in contexts such as "The birth of "Probabilistic Risk Assessment" as the guiding principle for understanding and mitigating risks in complex systems"; "recommended a radically sophisticated approach to risk assessment, leveraging a new technique called Probabilistic Risk Assessment"; "Probabilistic Risk Assessment grew to become the dominant language for analyzing nuclear risk". It most often appears alongside 1960 Valdivia earthquake, AEC, Atomic Energy Commission.

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1
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1
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July 01, 2023
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July 01, 2023
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Your Book Review: Safe Enough?
July 01, 2023 · Original source
Yet "Safe Enough?" is less of a history of events than a biography of an idea, the birth of "Probabilistic Risk Assessment" as the guiding principle for understanding and mitigating risks in complex systems. The heroes of Wellock's book are not nuclear plant night shift assistant supervisors, or the Nuclear Regulatory Commission training and assessment specialists, though they each make important cameos. The city of Toledo, Ohio is not safeguarded by watchful superheroes. It is protected by a methodology.
The leader of this effort to reinvent nuclear risk assessment was MIT engineering professor Norman Rasmussen, who was tasked with developing quantitative risk measures in terms easily understood by the public. Rasmussen recommended a radically sophisticated approach to risk assessment, leveraging a new technique called Probabilistic Risk Assessment.
Probabilistic Risk Assessment grew to become the dominant language for analyzing nuclear risk, and launched a set of practices that changed the culture of the industry forever. Yet in 1974, nearly all of US nuclear generating capacity was less than 5 years old. Unsurprisingly, this first implementation of Probabilistic Risk Assessment was too simplistic.
Inline links: less than 5 years old
procedural memory1 mentions across 1 issues

procedural memory is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between May 13, 2022 and May 13, 2022. The archive places it in contexts such as "consciousness also helps for procedural memory". It most often appears alongside Are We Smart Enough To Know How Smart Animals Are?, Astralcodexten, attention.

Reference entry
procedural memory
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1
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1
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May 13, 2022
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May 13, 2022
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Your Book Review: Consciousness And The Brain
May 13, 2022 · Original source
In this section, I will go a bit beyond the book, so this might be a bit less reliable than the rest. I have worked on research of neural plasticity and learning, so the ideas do not come entirely out of thin air. To understand the effect of consciousness on learning, you should first know that there are two different types of long-term memory, procedural and episodic memory. Procedural memory allows us to walk, ride a bike, or play the piano. For this review, I will pool it together with semantic memory: the knowledge that birds can fly, or things that you have learned by heart, like a song or the multiplication table. We can use procedural memory in automatic mode, and we can acquire and access it unconsciously. Acquiring procedural memory often requires a lot of practice and repetition. This type of learning is usually slow and decentral in the brain: only the regions which are directly relevant to the task are involved in this type of learning. It shares many similarities with modern machine learning systems.
On the other hand, episodic memory refers to specific moments of your life, for example remembering what you had for breakfast or what your conversation partner said five minutes ago. This memory is one-shot, so the memory is instantaneously formed and does not require any repetition. Aspects of episodic memory can be transferred into procedural memory: when you learn the name of your new colleague, then this stays an episodic memory for a while, but it becomes procedural/semantic memory after a few repetitions. Sometimes we don't even need repetition, for example when we recognize a face after a single meeting, or when a child acquires new words. But this relies on complicated interaction between the two types of memory that I won't get into here. Usually, we can make a clear distinction. It seems that episodic memory without consciousness is plainly impossible, and I will come back to that.
But consciousness also helps for procedural memory, even though it can be formed from purely unconscious perceptions. First, think of consciousness as giving a boost to the learning rate. I have mentioned before that episodic memory (which requires consciousness) can be transferred into procedural memory during sleep, and this is stronger than the effect of the direct experience alone. You will still not be able to learn the piano in a week, but consciousness probably makes learning faster. Second, as Dehaene explains in his book, you only connect unconscious events with each other if they are simultaneous. This makes sense because unconscious neural activity fades away so quickly. Dehaene describes some classical conditioning experiments similar to Pawlow's dog, where the sound of a bell is associated with receiving food. But if (to stay in the picture) the bell is perceived unconsciously, then the connection is only made if the bell rings while the reward comes (plus/minus at most one second), not if the bell rings a few seconds earlier.
Professors of Biology1 mentions across 1 issues

Professors of Biology is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between October 25, 2021 and October 25, 2021. The archive places it in contexts such as "they are never going to be Professors of Biology". It most often appears alongside Adrian Hon, Albert Einstein, Alternate reality games.

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Professors of Biology
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1
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1
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October 25, 2021
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October 25, 2021
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Epistemic Minor Leagues
October 25, 2021 · Original source
One place you could go from here is to talk about how QAnoners are the sort of people who are excluded from existing systems of knowledge production. They are never going to be Professors of Biology, and they know it. Their only hopes of being taken seriously as an Expert - a position our culture treats as the height of dignity - is to create a complete alternate system of knowledge, ungrounded in any previous system, where they can end up as an expert on the Lizard Papacy.
Profits1 mentions across 1 issues

Profits is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between April 16, 2021 and April 16, 2021. The archive places it in contexts such as "Profits is "almost synonymous" with revenue". It most often appears alongside "The Rent Is Too Damn High!", 16th amendment, 1886.

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Profits
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1
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1
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April 16, 2021
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April 16, 2021
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Your Book Review: Progress And Poverty
April 16, 2021 · Original source
By making possible the division & specialization of labor (you dig bait, I'll catch fish) Capital is a force multiplier that supercharges the productive power of labor. It doesn't supply labor with raw materials (nature does), nor does it provide for the maintenance of workers (who eat bread by the sweat of their own brow). George says this is why capital isn't a limit on industry. ...okay, George grants that capital may limit the form of industry. You can't plow without a plow or milk without a cow. George also grants that the lack of specialized tools can greatly limit productivity because you don't get the benefit of the force-multiplying effect of capital. Um... aren't you contradicting yourself here, Mr. George? You spent all this time hammering home your doctrine of wages to prove that capital doesn't limit industry, but you just said its absence can limit both the form and the productivity of labor! Time to unpack what we mean by "limit" and be super clear about it from now on: But to say that capital may limit the form of industry or the productiveness of industry is a very different thing from saying that capital limits industry. Okay, what do you mean? For the dictum of the current political economy that "capital limits industry," means not that capital limits the form of labor or the productiveness of labor, but that it limits the exertion of labor. Okay, I think I see what he's saying. The existing school of thought says that because capital provides labor with both materials and maintenance, therefore if capital dries up, labor productivity must go down because workers will have nothing to work on, and nothing to eat or wear. Labor is thus "limited" by capital, for without it is literally and metaphorically starved for capital. But George says no – the only way capital actually "limits" productivity in real life is in the degrees by which it force-multiplies labor's productivity and unlocks certain forms of labor in the tech tree. The kind of "limit" George objects to is the idea that you need capital just to get any work done at all, or that without capital to sustain it, labor will shrivel up. Instead, capital is rocket fuel that labor supplies to itself by investing a portion of its wages. And yet, with all the awesome slots we've unlocked on the tech tree, and barrels and barrels of rocket fuel to fire up eager laborers, we still find our economy sinking into mysterious depressions. Something is gumming up the works, but it's not a simple scarcity of capital: the real limitation is not the want of capital, but the want of its proper distribution Or as G.K. Chesterton said, "Too much capitalism does not mean too many capitalists, but too few capitalists." This might seem like a pedantic distinction – misallocated capital could be said to be "scarce" capital – but they're not the same thing at all. As Francis Bacon said in 1625: Riches were like [Manure]: When it lay, upon an heape, it gave but a stench, and ill odour; but when it was spread upon the ground, then it was cause of much fruit. Because the prevailing theories of George's time are based on incorrect ideas about the relation between wages and capital, "all remedies, whether proposed by professors of political economy or workingmen, which look to the alleviation of poverty either by the increase of capital or the restriction of the number of laborers or the efficiency of their work, must be condemned." In short, more investment, more protectionism, and more efficiency programs can't, won't, and haven't fixed poverty and industrial depressions because they all proceed from false premises. Having finally beaten the nexus of wages, capital, and labor into a bloody pulp, George turns his eyes towards another leading theory for why everything is terrible: the specter of overpopulation. II. Population and Subsistence The entire second book might as well be titled "Why Malthus is Dumb and Wrong and Bad." It's dedicated to dunking on Malthusianism, a philosophy that ascribes economic crises to the exponential growth of the human population, which must necessarily end in catastrophe. according to Malthusian theory, poverty appears as increase in population necessitates the more minute division of subsistence. George attacks Malthusian ideas not just because they're wrong, but because they make it easier to accept the prevailing theory of wages (as more capital is allocated, laborers will keep popping up like weeds to gobble it up, so wages must eternally stagnate). George draws a straight line between these faulty ideas and holocausts and genocides – specifically citing how colonial oppression in China, India, and Ireland were explicitly justified on Malthusian grounds. One million people died in the English-engineered Irish potato famine alone, and when you add in those who fled the entire population declined by 25% percent. And this isn't a tenuous link either – George directly connects the completely avoidable famine to his favorite bugbear, private landownership and extortionate rent. Given that Malthusianism is now widely discredited I'm just going to skip this chapter, but if you want to hear George in all his righteous fury, check out Appendix A (there's a link that returns here at the end): Appendix A: George Dunks on Malthusianism III. The Laws of Distribution When society produces wealth, who gets different shares of it, and why? Let's start by beating some words to death. By George, we're told that there are three factors in production: Land, Labor, and Capital. For each of these terms there must be a "law of distribution" that explains how each gets compensated for its part in production. The reward you get from production by owning Land is called Rent. The reward you get from production by supplying Labor is called Wages. The reward you get from production by supplying Capital is called ... um, what? We're looking for a term that clearly expresses the return to capital alone and nothing else. The closest thing we have is Interest, and that's probably good enough. George gives the common definition of interest as "the return for the use of capital, exclusive of any labor in its use or management, and exclusive of any risk, except such as may be involved in the security." This is pretty close to what we want – something that expresses the sole return to capital without mixing in anything else. But ... what about Profits? Profits is "almost synonymous" with revenue, assuming you have some left after you deduct expenses. It means a gain in money or wealth, but the trouble is this gain is a mix of rent, wages, and "compensations for the risk peculiar to the various uses of capital." What we want is a term that means the return to capital alone, totally separate from the return to laborers and landowners. To talk about the distribution of wealth into rent, wages, and profits is like talking of the division of mankind into men, women, and human beings. George spends a few pages talking about how everyone from Adam Smith on down got confused about this (spoiler: it's tied up with thinking wages are drawn from capital), before presenting his model for how it all works. If you want to see him knock that stuff down, see Appendix B (there's a link that returns here at the end): Appendix B: George dunks on the Conventional Laws of Distribution Here's George's model for how it all works: Land is"all natural opportunities or forces" and its return is rent Labor is "all human exertion" and its return is wages Capital is"all wealth used to produce more wealth" and its return is interest George says the false assumption at the root of the old theories is in thinking of "capital as the prime factor in production, land as its instrument, and labor as its agent or tool." George makes the following assertions: "Labor can be exerted only upon land"
Inline links: Francis Bacon said in 1625, Malthusianism, English-engineered Irish potato famine, Appendix A: George Dunks on Malthusianism, Appendix B: George dunks on the Conventional Laws of Distribution
Towards a Truly Free Market by John Medaille Appendices These are optional elaborations on sections I glossed over because the Book Review Is Too Damn Long. Appendix A: George Dunks on Malthusianism Malthusianism in George's time was wildly popular, and often invoked by the ascendant proponents of Social Darwinism who took Charles Darwin's theory of "survival of the fittest" and recast it as a moral justification for the Just World Hypothesis. Essentially, those that are doing well do so because they are more "fit", and those that are less "fit" tend to perish, and furthermore, this brutal process will actively "improve" the human race. This philosophy was the energizing intellectual force behind both the Eugenics movement and Nazi Germany. George clearly hates everything about this philosophy but attempts to steel-man it anyways: The Malthusian doctrine, as at present held, may be thus stated in its strongest and least objectionable form: That population, constantly tending to increase, must, when unrestrained, ultimately press against the limits of subsistence, not as against a fixed, but as against an elastic barrier, which makes the procurement of subsistence progressively more and more difficult. And thus, wherever reproduction has had time to assert its power, and is unchecked by prudence, there must exist that degree of want which will keep population within the bounds of subsistence. The weak form of Malthusianism is "people are as dumb as deer and will breed endlessly until there's not enough food and everyone starves to death." The strong form of Malthusianism is, "of course people aren't mindless deer charging into a brick wall, but there is a firm upper limit that can only give so much before nature will cull the herd without mercy." And by George, we can't just dismiss the strong form out of hand: "what seems clearer than that there are too many people?" However, George is suspicious of how easily the Malthusian theory justifies contemporary economic assumptions and assuages the moral sensibilities of the establishment: The great cause of the triumph of this theory is that, instead of menacing any vested right or antagonizing any powerful interest, it is eminently soothing and reassuring to the classes who, wielding the power of wealth, largely dominate thought... It furnishes a philosophy by which Dives as he feasts can shut out the image of Lazarus who faints with hunger at his door; He points out how it lets self-styled "Good Christian Men" reframe their own greed and indifference as just plain good sense: In this view, he who in the midst of want has accumulated wealth, has but fenced in a little oasis from the driving sand which else would have overwhelmed it. He has gained for himself, but has hurt nobody. And even if the rich were literally to obey the injunctions of Christ and divide their wealth among the poor, nothing would be gained. (Aside: I've heard this exact defense offered by many of my fellow Christians) Okay, George makes a strong moral case. But a moral case isn't enough, and I think this is where many activists of all political stripes go wrong. If you attack the premises of an idea as "dangerous" because it could lead to bad consequences, you're still stuck with a real problem if the premises that animate that "dangerous" idea turn out to be actually true. If they're true we're stuck with them, and unless your competing policy admits to the same grim facts, your opponent will just dismiss your entire argument and more importantly, so will their audience. But if the premises aren't true, then the dangerous and scary policy prescription – say, "let the Irish starve to death" – is both evil and unnecessary. History has shown that many officials will shrug their shoulders at "evil" policies so long as they believe them to be "necessary." Cool, we've established that Malthusianism is bad. Now let's establish that it's wrong. A Brief Interlude from the Future From where we're sitting in 2021, we don't even need George to refute Malthusianism, history has done that for us. Instead of increasing at an exponential rate, fertility rates are crashing all over the world. Not in one country, but in virtually every country, and in many the birth rate is already below replacement. Fertility rates have been crashing so hard that some are calling it a "Global Fertility Crisis." The absolute size of the human population is still growing, but this is just due to inertia; the human population will peak somewhere between 9 and 10 billion in the 2060's, and then decline from there. The two main things Malthus got wrong were failing to anticipate 1) advances in food production technology like the Green Revolution, and 2) that humans can control their own fertility rates. George's strongest arguments against Malthusianism strike directly at the provably false claims of its 19th century proponents and provide some extremely salient applications of George's philosophy. George takes up the cause of India, China, and Ireland, which were often cited as examples of "overpopulated" countries where many have starved and been forced to emigrate. Per the Malthusians, this is the fault of too many of these poor, ignorant, and deficient people crammed together in too small a space. By George, it can't be the fault of population density – in his time, Germany, Belgium, England, Netherlands and Italy all have higher population densities than India, China, and Ireland, and could therefore support higher populations with the right conditions. And there's certainly nothing wrong with the people themselves: This arises from no innate deficiency in the people, for the Hindoo, as comparative philology has shown, is of our own blood, and China possessed a high degree of civilization and the rudiments of the most important modern inventions when our ancestors were wandering savages. Instead: It arises from the form which the social organization has in both countries taken, which has shackled productive power and robbed industry of its reward. India is poor not because it has too many Indians, but because it is oppressed by too many Englishmen: The millions of India have bowed their necks beneath the yokes of many conquerors, but worse of all is the steady grinding weight of English domination... India now is like a great estate owned by an absentee and alien landlord George gives us lots of details about the plight of India, China, and Ireland, but for the sake of brevity I'm just going to present the heartbreaking case of the Great Irish Potato Famine and let it stand in for all three. To sum up, from 1845 to 1852 there was a period of mass starvation and disease in Ireland. About one million people died, and another million fled the country. The entire population dropped by about 25%: The extreme poverty of the peasantry and the low rate of wages there prevailing, the Irish famine, and Irish emigration, are constantly referred to as a demonstration of the Malthusian theory worked out under the eyes of the civilized world. Many prominent intellectuals of the day looked at the crisis, shook their heads, and said – what do you expect when those ignorant Irish Catholics breed like rabbits and strain Ireland's carrying capacity to its limit? It's just natural selection at work! George will have none of it: The laborer was just as effectually stripped by as merciless a horde of landlords, among whom the soil had been divided as their absolute possession, regardless of any rights of those who lived upon it. Okay, they had to pay some rent, so what? Didn't they bring their suffering on themselves? Why, the intellectuals ask, didn't the Irish work harder, why did they not improve their local economy and agricultural base? And most importantly, why did they depend on a single monoculture crop (the potato) if a single blight could knock out their entire food supply? By George, because The Rent Was Too Damn High! tenants... even if the rack-rents which they were forced to pay had permitted them, did not dare to make improvements which would have been but the signal for an increase of rent. Labor was thus applied in the most inefficient and wasteful manner. (emphases mine) The Irish were really trapped. Working harder to improve the farmland to increase its yield could actually leave them worse off. Any increase in their land's productivity goes to the landlord in the form of increased rents. But even this structural impoverishment of the land wasn't sufficient to cause the famine. Ireland still produced enough food to feed its people: For when her population was at its highest, Ireland was a food-exporting country. Even during the famine, grain and meat and butter and cheese were carted for exportation along roads lined with the starving and past trenches in which the dead were piled. People were literally starving and dying, but because of the structure of land ownership they couldn't even pay their rent, let alone purchase the food grown from their own lands and raised with their own hands. Since the local population couldn't afford it, the (English) landlords sold it abroad to the highest bidder. It went not as an exchange, but as a tribute – to pay the rent of absentee landlords; a levy wrung from producers by those who in no wise contributed to production... they lived on the potato, because rack-rents stripped everything else from them. The Rent Is Too Damn High, and it's not because the designated underclass of the day have too many babies or are too uneducated, too ignorant, too religious, too lazy, or too foreign. George gets really mad about this, and calls out John Stuart Mill and Henry Thomas Buckle by name for lending credence to the Malthusian explanation of Ireland's suffering. I know of nothing better calculated to make the blood boil than the cold accounts of the grasping, grinding tyranny to which the Irish people have been subjected, and to which, and not to any inability of the land to support its population, Irish pauperism and Irish famine are to be attributed; and were it not for the enervating effect which the history of the world proves to be everywhere the result of abject poverty, it would be difficult to resist something like a feeling of contempt for a race who, stung by such wrongs, have only occasionally murdered a landlord! Appendix B: George dunks on the Conventional Laws of Distribution Conventional Law 1: Wages aredetermined by the ratio between capital devoted to the payment & subsistence of labor, divided up by the number of laborers. Conventional Law 2: Rent is determined by something called the "margin of production," AKA the "margin of cultivation." What's that? Let L be some land. Let W be the worst land available. Let A = the produce L makes. Let B = the produce you get applying the same amount of labor and capital to W. The Rent of L is given by A - B. The margin of production/cultivation is the difference between how much you can produce from a particular piece of land compared to the least productive alternative. This is the only conventional law of distribution that George accepts as correct. Conventional Law 3: Interest is the ratio between capital demanded by borrowers and supplied by lenders, falling as wages rise and vice versa. To quote Mill, interest is determined "by the cost of labor to the capitalist." The problem with these three laws is if Land, Labor, and Capital are the only three factors of production, and each gets its own return, than the three returns should balance. In other words: Return to Production = Rent + Wages + Interest If your three returns sum to more or less than 100% of the return to production, something's off, and George says the old laws don't add up – the only one of these he accepts is the law of rent. What's wrong with the other two? First we've got to stop using "profits" to mean a return to capital. If we look into a profit stream, we see more than one kind of thing. Conventional economists list the following: Wages of "superintendence"
Inline links: Towards a Truly Free Market, Social Darwinism, Just World Hypothesis, Eugenics, so long as they believe them to be "necessary.", fertility rates are crashing all over the world, Global Fertility Crisis, human population will peak, Green Revolution, Great Irish Potato Famine
Progeria1 mentions across 1 issues

Progeria is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between June 01, 2021 and June 01, 2021. The archive places it in contexts such as "Progeria is a rare disease that makes people age unnaturally quickly". It most often appears alongside Alzheimers, beta amyloid plaques, FDA.

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Progeria
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1
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1
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June 01, 2021
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June 01, 2021
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What Do Treatments For Accelerated Aging Tell Us About Normal Aging?
June 01, 2021 · Original source
Progeria is a rare disease that makes people age unnaturally quickly. Babies born with progeria can lose their hair in toddlerhood, get wrinkles by grade school age, and die - apparently of old age - in their early teens. You can see a picture of a progeroid child here, though I don't recommend it.
Inline links: here
There's been a lot of research on one important form - Hutchinson-Gilford Syndrome - and just last year, the FDA approved the first treatment, a drug called lornafarnib. In the study, a few hundred children averaging around 7 years old took the drug for two years; 3% died during that time. In an ad hoc group of untreated comparison children, about 30% died during the same period. I'm a little confused by the methodology - it seems like the "comparison children" were chosen partly because they died too early to get into the trial, which sounds like a pretty major confounder - but everyone seems to treat this as reasonable so I will assume they adjusted for this in some way. If that's true, then lornafarnib cuts mortality by 90%.
Inline links: approved the first treatment
That's great for the 300 or so children worldwide with Hutchinson-Gilford progeria (it's a really rare disease). But none of the discussion about this answered the question I wanted to know: can lornafarnib also prevent normal aging?
progerin1 mentions across 1 issues

progerin is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between June 01, 2021 and June 01, 2021. The archive places it in contexts such as "they produce a defective mutant protein called progerin"; "Maybe progerin is one of these proteins and causes some of the problems commonly associated with aging?". It most often appears alongside Alzheimers, beta amyloid plaques, FDA.

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progerin
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1
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1
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June 01, 2021
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June 01, 2021
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What Do Treatments For Accelerated Aging Tell Us About Normal Aging?
June 01, 2021 · Original source
Hutchinson-Gilford progeria (I'll just say "progeria" from here on, even though that's kind of inaccurate) is what's called a laminopathy. It's a disease of the nuclear lamina, a weblike structure that helps support and give shape to the cell nucleus. The lamina is partly made of a protein called lamin A. Children with progeria have a mutation in the relevant gene; instead of producing lamin A, they produce a defective mutant protein called progerin. The cell tries to build the nuclear lamina out of defective progerin instead of normal lamin A, and as a result the cell nucleus is screwed up and can't maintain a normal shape.
Lornafarnib interferes with the production of the defective progerin protein. As best I can tell, it doesn't cause the cell to produce healthy lamin A - it just prevents the defective mutant version from accumulating. For whatever reason, the cells without lamin A do surprisingly okay as long as they don't have the defective mutant version. So this prevents most of the DNA repair problems, and so decreases premature aging.
I don't really get what's going on here. I know that often, as age-related damage degrades DNA, a lot of weird malformed proteins pop up and accumulate - for example, the beta amyloid plaques that might (or might not) be involved in Alzheimers. Maybe progerin is one of these proteins and causes some of the problems commonly associated with aging? But what percent of the problems? If it and 99 other defective proteins each cause 1%, not really a big deal. If it's 50%, bigger deal - but nothing is ever that easy.
Inline links: beta amyloid plaques
programming1 mentions across 1 issues

programming is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between June 27, 2025 and June 27, 2025. The archive places it in contexts such as "Academic competitions like chess, go, debate, public speaking, robotics, programming". It most often appears alongside 10,000 hour rule, 2 Hour Learning, Inc, 2-hour Learning.

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programming
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1
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1
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June 27, 2025
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June 27, 2025
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Your Review: Alpha School
June 27, 2025 · Original source
GT School (Georgetown, TX) — Alpha’s “Gifted and Talented” School. Higher admissions bar; higher academic expectations; Afternoon programming focused on excelling in “academic competitions” like chess, go, debate, public speaking, robotics, programming and Quiz Bowl.
Inline links: GT School
Programming (not competitive so far, but potentially building that way)
Some kids will rush into college classes. Some will choose to use the time to play sports. Some will use the time to master chess or quiz bowl or programming. Some will take time to travel the world with their families.
Progress1 mentions across 1 issues

Progress is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between October 24, 2024 and October 24, 2024. The archive places it in contexts such as "interesting commentary on the idea of Progress". It most often appears alongside 1960: The Year The Singularity Was Cancelled, 1960s, 1973.

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Progress
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1
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1
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October 24, 2024
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October 24, 2024
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Notes From The Progress Studies Conference
October 24, 2024 · Original source
Tyler Cowen is an economics professor and blogger at Marginal Revolution. Patrick Collison is the billionaire founder of the online payments company Stripe. In 2019, they wrote an article calling for a discipline of Progress Studies, which would figure out what progress was and how to increase it. Later that year, tech entrepreneur Jason Crawford stepped up to spearhead the effort.
Inline links: Marginal Revolution, wrote an article
The immediate reaction was mostly negative. There were the usual gripes that “progress” was problematic because it could imply that some cultures/times/places/ideas were better than others. But there were also more specific objections: weren’t historians already studying progress? Wasn’t business academia already studying innovation? Are you really allowed to just invent a new field every time you think of something it would be cool to study?
Inline links: mostly negative
It seems like you are. Five years later, Progress Studies has grown enough to hold its first conference. I got to attend, and it was great.
progressive Establishment of today1 mentions across 1 issues

progressive Establishment of today is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between July 11, 2024 and July 11, 2024. The archive places it in contexts such as "or the progressive Establishment of today". It most often appears alongside Americans, Backscratchers Club, Backscratchers Clubs.

Mention count
1
Issue count
1
First seen
July 11, 2024
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July 11, 2024
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Lifeboat Games And Backscratchers Clubs
July 11, 2024 · Original source
If the Lifeboat Games seemed suspiciously like nationalism, and the Backscratchers Clubs seemed suspiciously like clubs/cults/ideologies, the stories in this section seem suspiciously like the Establishment - whether it’s the Catholic Establishment of the Middle Ages, the conservative Establishment of mid-20th-century America, or the progressive Establishment of today. Elites support each other not directly - which would be hard to coordinate - but by all supporting the same ideology. If it’s hard for non-elites to break into the ideology, then everyone with the ideology will be elites, and supporting the ideology is an indirect way of elites supporting other elites in a big backscratching network. This is one of the solutions to Class Warfare Having A Free Rider Problem.
Inline links: Class Warfare Having A Free Rider Problem
progressive property tax1 mentions across 1 issues

progressive property tax is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between December 10, 2021 and December 10, 2021. The archive places it in contexts such as "Wyatt's preferred alternative is a progressive property tax". It most often appears alongside A. R. Hutchinson, ATCOR theory, Australia.

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Does Georgism Work? Part 2: Can Landlords Pass Land Value Tax on to Tenants?
December 10, 2021 · Original source
Wyatt's chief argument is that the supply of land is not really fixed; the true figure should not be "all the land there is" but rather "all the land supplied to the market within a given jurisdiction," which he asserts is constantly changing. He further notes that many proponents of LVT, such as the famed Georgist Mason Gaffney, themselves admit that under certain conditions, the price of land may not change in the wake of an LVT being levied (this is due to Gaffney's ATCOR theory that any cuts in labor and capital taxes cause land rents to rise). He goes on to attack many other assumptions of the Georgist philosophy and ultimately claims that "there is no reliable evidence for the capitalization effect which proponents believe would reduce land prices." Wyatt's preferred alternative is a "progressive property tax," essentially a wealth tax. He goes on:
Progressive Republican1 mentions across 1 issues

Progressive Republican is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between July 08, 2022 and July 08, 2022. The archive places it in contexts such as "Carter is less of a Democrat and more of a 1920’s-style Progressive Republican in the model of Teddy Roosevelt". It most often appears alongside 1968 convention, 1976 Democratic, 1976 Democratic primary.

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Progressive Republican
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July 08, 2022
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July 08, 2022
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Your Book Review: The Outlier
July 08, 2022 · Original source
But some of the conflict is structural. To his credit, Carter is one of the first politicians to see that the post-New Deal consensus is fraying. Economic growth is slowing, inflation is rising, union membership is declining, all of which means that the traditional Democratic way of doing things—launching new federal programs, catering to interest groups, and accepting some waste and inefficiency as a cost of doing business—is on its way out, even if the old-school Dems don’t realize it yet. Really, Carter is less of a Democrat and more of a 1920’s-style Progressive Republican in the model of Teddy Roosevelt: focused on efficient, rational government, non-ideological problem-solving, and ethical stewardship.
progressive supranuclear palsy1 mentions across 1 issues

progressive supranuclear palsy is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between August 14, 2025 and August 14, 2025. The archive places it in contexts such as "distinct human tauopathies, including progressive supranuclear palsy". It most often appears alongside A. Bejanin, A. de Calignon, A. Elobeid.

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August 14, 2025
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August 14, 2025
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In Defense Of The Amyloid Hypothesis
August 14, 2025 · Original source
Overproduction or reduced clearance due to microbial infection. Amyloid-β appears to be an antimicrobial peptide and will form plaques in response to infection. [2, 3] This explains various observations that have been used to support the “infectious hypothesis”, sometimes proposed as an alternative to the amyloid hypothesis. However, it can only explain a subset of cases and, as I argue below, is even then still mediated by amyloid via an “IATN” pathway: infection → amyloid → tau → neurodegeneration. In cases of increased production, cerebrospinal fluid (CSF) will show elevated amyloid. In cases of reduced clearance, amyloid will decrease in CSF. In all cases, however, PET scans will show elevated brain amyloid, usually at first mainly in “intrinsic connectivity networks” such as the default mode network [14–20], which experience brain activity even at rest. These neurons are the most active - which causes more production and possibly less opportunity for clearance - so they tend to be the first to suffer from a production/clearance imbalance. Over time, amyloid pathology spreads spatially throughout the brain. [14, 18] Aggregations of amyloid peptides induce more such aggregations. Some of our clearest evidence for this comes from growth hormone deficiency patients, who used to have cadaver-derived ground-up brain matter injected into their own brains to provide the missing hormones. If the ground-up brain matter was sourced from the corpse of an Alzheimer’s patient, the growth hormone deficiency patients would themselves develop Alzheimer’s at a young age, probably through prion-like spread of the misfolded proteins. [21, 22] After ∼15 years of preclinical spread, the pathology eventually covers the whole brain. [14, 18] While some subtle cognitive impairment may occur during this time, it is usually not severe enough to be clinically detectable from amyloid alone. Indeed, in both humans [23–30] and mice [31–35], the severity of neurodegeneration and cognitive deficits is not a good spatiotemporal match for the severity of amyloid pathology (rather, it is a good match for the severity of tau pathology; see next section for more). These facts are often suggested as evidence against the amyloid hypothesis. However, amyloid is causally upstream of tau, as I will argue below. Therefore, the existence of cognitively normal individuals with amyloid pathology is expected in the ATN model - but typically only for a few decades, before progression to the next stage. 2: Tau pathology (T) and neurodegeneration (N) Tauopathies are a range of prion-like diseases involving the tau protein [36], whose usual function is to assist in stabilizing microtubule structure. In a tauopathy, the tau protein misfolds, and induces other, nearby tau proteins to misfold into the same shape. [37–46]. Injecting nothing but misfolded tau fibrils into a mouse brain can recruit the endogenously-produced mouse tau into this pathology, which spreads far beyond the injection site, causing neurodegeneration wherever it goes. [35, 47–59] There are at least eight distinct ways the tau protein can misfold in human disease [36], and over a dozen distinct human tauopathies, each involving a specific one of those misfoldings. These include chronic traumatic encephalopathy, Pick’s disease, corticobasal degeneration, progressive supranuclear palsy, and Alzheimer’s disease, with the last by far the most common. Each of these five diseases has its own distinct tau fold. Most normal human beings eventually develop some tau pathology in adulthood, originating probably in the locus coeruleus [60–62], which is part of the brainstem. By middle age, some amount has usually spread to the hippocampus and entorhinal cortex in the medial temporal lobe, regions responsible for episodic memory. This is called primary age-related tauopathy (PART) [63], and has its own tau fold which is distinct from most tauopathies, but the same as Alzheimer’s. [36, 64] Usually, its local severity is mild and it doesn’t spread much beyond those regions. But with sufficient amyloid pathology, this “normal” tau pathology tends to both locally worsen and spread through the rest of the brain [65], becoming the tau pathology of Alzheimer’s. Some genetic risk factors such as ApoE, in addition to affecting the clearance of amyloid-β, also increase the brain’s susceptibility to this A → T pathology conversion [66, 67]. But this is a matter of degree, as sufficient amyloid pathology seems to virtually guarantee the transition: Every 10-centiloid increase in amyloid pathology for a cognitively normal individual increases by 2.7x the probability of a PET scan detecting pathological levels of tau within five years [68]. The only known cases where patients with extremely high amyloid levels can go significant amounts of time without developing tau pathology are a few individuals with extremely rare protective genes, known only from a few case studies, e.g. [69]. Even in these instances, the individuals will eventually succumb to the tau phase, suffering neural atrophy and dementia. [70] After it forms, the tau pathology no longer appears to require amyloid’s assistance to keep spreading (although amyloid may still accelerate it). This probably explains why existing anti-amyloid therapies have been only ∼30% effective in test patients, who are usually late in the amyloid → tau progression even if early in having symptomatic disease. Neurodegeneration follows tau pathology extremely closely in time and space, in humans as well as basically all animal models, and cognitive impairments match the functions of the affected regions. There are rare reports of advanced tau pathology without cognitive decline, often in people with protective ApoE2 alleles [71], but even then, systematic analysis finds that actual density of tau inclusions is highly predictive of cognitive impairment, and that these exceptional cases usually involve widespread but locally sparse pathology [66]. The regional distribution of tau pathology explains why the first symptom of Alzheimer’s is typically impaired memory; the first cortical sites affected are usually in regions involved in memory formation. As the pathology spreads, further regions are affected, until eventually all cognitive functions are affected. As with most other aspects of the disease, the high-level picture seems relatively clear but the exact cellular and molecular pathways are not well understood (though may involve an assist from the innate immune system, especially microglia and astrocytes. [13, 35, 72]) Early Alzheimer mouse models were amyloid-only, with extremely heavy overproduction of Aβ, much more than required to recapitulate the human disease, and apparently enough to cause detectable cognitive dysfunction. However, normal mice do not get age-related tauopathy, so an amyloid-only mouse model - while useful for investigating certain questions - is not a full Alzheimer’s disease model. Combined amyloid+tau pathology mouse models, which are transgenically modified and/or injected with misfolded human tau fibrils, display the property that the presence of amyloid pathology induces the worsening and spreading of tau pathology. This is also observed in vitro in human cells. How do we know the amyloid causes the tau? Researchers have measured the correlation in many ways, from the spatiotemporal timeline (tau pathology only begins locally worsening and spreading outside the medial temporal lobe once amyloid reaches sufficient severity) [65], [98], to causal mediation modeling in the human disease [26], [99–101], to causal intervention using in vitro human cell studies [54, 102] and animal models [35, 55], [103 – 113]. But also, giving people drugs that reduce amyloid levels also decreases tau pathology. [78, 80, 82] (I’ve left out or merely alluded to much other complexity, involving the innate immune system, lipid processing, and detailed molecular and cellular mechanisms, preferring to focus on the parts of the story which are crucial to deciding the causal role of amyloid, and for which I am aware of a satisfactory account from the literature. But I don’t intend to leave the impression that the above is all there is to Alzheimer’s disease, or that all cases progress in the same exact way.) The mechanistic claims I make the following two claims about amyloid-β’s role in Alzheimer’s: Amyloid deposits are a necessary (i.e. but-for) cause in all instances of Alzheimer dementia. That is, if someone has PET or CSF positivity for amyloid and tau pathologies, and the tau pathology involves the Alzheimer tau fold and made its first cortical appearance in the medial temporal lobe, and then they developed medial temporal volume loss + amnestic mild cognitive impairment + later dementia, then counterfactually, early enough (probably ∼15 years before clinical presentation) causal intervention solely to remove the amyloid deposits would have prevented almost all tau pathology and symptoms.
Inline links: below, probably through prion-like spread of the misfolded proteins, 10-centiloid, have been, the presence of amyloid pathology induces the worsening and spreading of tau pathology
Progressive virtues1 mentions across 1 issues

Progressive virtues is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between July 30, 2024 and July 30, 2024. The archive places it in contexts such as "I appreciate the Progressive virtues because of how skew they are". It most often appears alongside /r/iamverysmart, 4chan, Achilles.

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Progressive virtues
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1
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July 30, 2024
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July 30, 2024
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Matt Yglesias Considered As The Nietzschean Superman
July 30, 2024 · Original source
It’s Progressive-era propaganda about the superiority of the American North over the South, but I find it most interesting for its list of virtues. It starts with Liberty, then moves on to Free Speech, Intelligence, Obedience To Law, Knowledge, Equal Rights, Free Schools, Contentment, Love Of Country, Philanthropy, Benevolence, Happiness, Patience, Charity, Faith, Hope, Joy, Industry, Sobriety, Morality, Justice, Virtue, Truth, Honor, Peace, Light, and Immortality. I appreciate the Progressive virtues because of how skew they are to most of the ethical systems I encounter. They’re not leftist (Love Of Country? Industry? Morality?) or rightist (Equal Rights? Free Schools?). They’re not Nietzschean master moralist (Philanthropy? Contentment? Benevolence?) or slave moralist (Industry? Knowledge? Honor?). They’re Christian-ish, but not hair-shirts-and-self-flagellation Christian or God-n-guns-megachurch Christian. They’re the kind of Christians who you can kind of tell are going to end up supporting eugenics in a few years. I think I would classify them as a first-form-slave-morality liberalism, whereas most of the liberalism you encounter these days drifted at least a little into the second form. I’m not 100% on Team Early 20th Century Progressive, but they give me hope that there are weird-yet-coherent groupings of virtues we haven’t even imagined. I feel the same way about some old Soviet posters: These are obviously left-wing, in the sense that they’re literal Communist propaganda. But to the modern eye there’s something off about them, something that makes you want to call them right-wing or even fascist. They’re bold and optimistic. Even though the commissars who commissioned them probably rejected some traditional or capitalist conception of virtue, they still firmly insist that there’s something sort of like virtue or power which is attainable and good. I think these are first-form posters, and that most modern leftism is second-form. I think if you had to group barbarian warlords, Puritans, Soviet communists, and modern leftists on a Nietzschean/geneaological/aesthetic axis, it would go: (Barbarian warlords) | (Puritans, Soviet communists) | (modern leftists) So one very weak compromise - hardly even a compromise, since it predates Nietzsche - is to try to stick with first-form slave morality, in the hopes that most of the problems come from the second. VIII. Ayn Rand “Is Ayn Rand a Nietzschean?”- the greatest thread in the history of forums, locked by a moderator after 12239 pages of heated debate. There’s a real answer here. Rand started out respecting, maybe even loving Nietzsche. She once said that: [Nietzsche’s] Thus Spake Zarathustra is my Bible. I can never commit suicide while I have it. …which maybe reveals more about her psychological situation than I expected from the answer to a “who’s your favorite philosopher” questionnaire. But later on she broke from him. It’s hard to figure out her exact position - she has a bad habit of treating anyone who disagrees with her in any tiny detail as the Antichrist, such that it’s hard to figure out whether she thinks of someone as a 99% fellow traveler or an arch-enemy. Still, there are substantial differences. Nietzsche is more chaotic - he expects the superior man to defy all external rules in favor of his own glorious destiny. But Rand is attached to rules - most of all the epistemic rules of Reason, but also the usual moral tenets like “don’t kill” and “don’t steal”. Nietzsche’s masters take the Ron Swanson approach to justifying their actions: …whereas Rand’s masters are prone to giving twenty-page-long arguments for why whatever they’re doing is the right choice according to Objectively Correct Moral Law. Rand’s approach has lots of advantages. The Nietzschean master, like Andrew Tate, is an awful guy to have around. It’s hard to fit him into a functioning civilization, except maybe an autocracy with him as autocrat. Nietzsche’s pitch is “hey excellent people, you should try to become this guy”, never “hey normal people, you should support my project of creating these guys, out of your own self-interest.” The latter wouldn’t pass the laugh test. Rand’s masters, while still probably very stressful to be around, have been tamed. They follow civilized rules of honesty and nonviolence - not, of course, because they’re too weak to defy them, but because following civilized rules is objectively the coolest thing of all. Instead of competing in battle and leaving a trail of bloody corpses, they compete in Capitalism and leave a trail of high-paying jobs and excellent consumer goods. They’re not doing to serve you - “I should serve the little guy” is slave moralist bulls**t. But, by coincidence, their excellent actions are doing you a service. They might only invent rocket ships to enact their Promethean conquest of nature and prove their own greatness. But you still get to ride in one. Rand also spares more of a thought (or at least an afterthought) for the little guy. Capitalism needs all types - even the company janitor genuinely contributes to whatever glorious accomplishments are going on, and deserves to feel good about themselves. She wants everyone to be the best, most ambitious, and most fighting-for-their-own-aesthetic/moral-vision they can be. But if that means being the company janitor, that’s fine. And if you love rockets and you consummate that love by becoming the janitor for a rocket company, the Objectively Correct Moral Law is 100% on board. I am not a Nietzsche scholar, but I think this is a more productive answer than Nietzsche has for this question. The disadvantage of Rand’s approach compared to Nietzsche’s is that it only works if you believe her proofs about why the Objectively Correct Moral Law is definitely objective and correct - most of which seem to me to be either hand-wavy or balderdash. Otherwise the whole thing breaks down - why is the most masterful thing to be a positive-sum capitalist instead of a negative-sum warlord? Rand really really wants to justify a peaceful, glorious, positive-sum society, to the exact people most capable of benefiting from defecting against it, without bringing in altruism or the common good at any point. It’s an extremely sympathetic goal. But I don’t think she makes it. Still, this is why I’m fond of her. If you really read her books - as opposed to skimming them while subvocalizing “this is that evil woman who loves selfishness” under your breath the whole time - it’s obvious that she believes, with a deep and burning belief, that good things are good. She really really wants to think that you can objectively convince people to support a peaceful, glorious, positive-sum society, without any hint of the psychologically-toxic slave morality that typified the USSR she grew up in. When people react to her books with loathing - without even a hint of fondness - I get suspicious that they’ve gotten so deep into slave morality that thy can’t recognize goodness when it hits them over the head with a sledgehammer. Elsewhere, I wrote: Edward Teach (Sadly, Porn) is famous for making up fake novels to criticize, and it is a little known fact that the "Ayn Rand" character along with all her novels are 100% his work. They operate as a diagnostic test based on his psychodynamic theory of envy. The instrument presents a picture of some exceptional people achieving great things who don't apologize for their greatness, and doesn’t explicitly ask the patient - I mean, reader - for their opinion. If the reader has no strong opinion, or says something like "Good for them, I guess," she passes the test. "I like these people and will use them as a role model" also passes. Some specific criticisms (see below) may also pass. If the reader says "Ah, people who are better than the pathetic sheep around them, just like I'm better than all the pathetic sheep around me!", she . . . still passes the test. That's not what it's testing for! You fail the test if you absolutely freak out about some combination of the Rand characters themselves and the potential existence of arrogant people who identify with the Rand characters. The secret is that it's not a screening test for the kind of people who would get featured on /r/iamverysmart. It's a screening test for the kind of people who would comment on /r/iamverysmart, ie the self-designated Tall Poppy Police, ie the people who build their ego off being the enforcers of the rule that you're not allowed to look better than anyone else. These people's basic mental stance is to hate people who seem too excellent. They don't think of it in these terms. They think of it as calling out arrogance, although if you look too closely you'll find their definition of arrogance covers anyone who seems excellent and but doesn't spend all their time apologizing and abasing themselves and denying it. The brilliance of Teach-Rand is how he-she draws this tendency to the foreground For example, why the whole "Objectivism" thing? Not because value is necessarily completely objective, but because the idea that any value might ever be even partially objective freaks out the Tall Poppy Syndrome people. Mention value at all, and they say you must be trying to secretly smuggle in the assumption that you are more valuable than other people (and therefore you are less valuable than other people, and therefore they are better than you). The same is true of Reason. Mention that Reason exists, and they'll interpret it as a claim that you, the only rational person, are claiming to always be right and infallible. But (they retort) actually nobody knows anything, and the only wise people are the people like them who humbly admit this. (how do you decide what's true without Reason? By bias-based-reasoning - "You say X, but I can imagine a way that would come from a place of believing you're better than other people, therefore, Not-X is true. You say that's a logical fallacy? That must come from a place of believing you're smarter than everyone else and the only person who can use Facts and Logic.") The Teach-Rand test is designed to catch the sort of person who, if someone says that on a right triangle a^2 + b^2 = c^2, responds with "Oh, so you're claiming to be some kind of right triangle expert who's better than the rest of us? You really need to work on that arrogance problem! Super cringe!" Any criticism of the book that doesn't come from this particular place is irrelevant to the test and doesn't count against your grade. (which is good, because the books are bad in a lot of ways. But that's fine - Rorschach blots don't also have to be great art!) Still, I don’t think she’s the superman (superwoman?) who successfully transcends the dichotomy Her philosophy is only as strong as its proofs of Objective Correctness, which I consider weak. Without those, you need some subjective motivation to glue things together - of which altruism is the most popular. But also, don’t we like altruism? When we’re bestriding the Earth like colossi, working on our glorious rocket ships to colonize the universe, isn’t part of what we’re thinking “this is going to revolutionize humankind and make everybody better off?” If you force yourself to reject that motivation, to just repeat “no no no, I’m only doing this because rockets are really big and make cool explosions”, aren’t you cutting out a part of yourself, in exactly the way Nietzschean masters are supposed to try to avoid doing? I find something very compelling about Rand. I think she goes some of the way to answering the Andrew Tate objection to master morality. But she’s a means and not an end. A real superman would have to figure out some way to reintroduce basic human kindness. IX. Matt Yglesias Yglesias’s mantra - “good things are good” - is too perfect and profound to come from anyone other than an esoteric master of Nietzschean philosophy. Good Straussians ignore the title and focus on the subtitle. Nietzsche wrote in the 1890s. There were still real nobles and emperors walking around; communists had not yet started calling capitalism “late capitalism”. Sure, his world was probably some sort of weak compromise between master and slave morality, but it was different from our weak compromise. Our weak compromise was forged through dialogue and warfare with fascism’s novel take on master morality and socialism’s novel take on slave morality. I think of Yglesias - who combines an insistence that good things are good and a proclivity for embiggenment with commitments to democracy, the welfare state, and the poorest among us - as one of its most self-conscious proponents. When I first titled this post, I didn’t know that Richard Hanania had come to the same conclusion and created this face-mash-up of Matt Yglesias and Nietzsche. The compromise goes something like: Everyone is equal before the law, before the metaphorical throne of metaphorical God, and in some poorly defined philosophical sense. This is very important. It’s our headline result. Everything else should be interpreted in light of this central fact.
Inline links: https://substackcdn.com/image/fetch/$s_!6V8D!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F7f1f70cc-b468-4b04-b894-a8b75b3330e5_1024x683.jpeg, https://substackcdn.com/image/fetch/$s_!FF8B!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F0a1ac7aa-d19e-43e8-8462-210325b902be_810x545.png, a real answer here, https://substackcdn.com/image/fetch/$s_!OtNv!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F6ae1aaf2-6cc3-488c-b0a7-5df62eee457b_225x225.jpeg, Elsewhere, Sadly, Porn, /r/iamverysmart, https://substackcdn.com/image/fetch/$s_!MzIr!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Ff03d1a9d-5ffc-45ff-84bc-db3388915bbc_259x390.jpeg, https://substackcdn.com/image/fetch/$s_!hYvV!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fd0f9b152-da12-4525-b062-b4c14d8b8005_383x373.png
Progressive-era propaganda1 mentions across 1 issues

Progressive-era propaganda is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between July 30, 2024 and July 30, 2024. The archive places it in contexts such as "It’s Progressive-era propaganda about the superiority of the American North over the South". It most often appears alongside /r/iamverysmart, 4chan, Achilles.

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1
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1
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July 30, 2024
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July 30, 2024
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Matt Yglesias Considered As The Nietzschean Superman
July 30, 2024 · Original source
It’s Progressive-era propaganda about the superiority of the American North over the South, but I find it most interesting for its list of virtues. It starts with Liberty, then moves on to Free Speech, Intelligence, Obedience To Law, Knowledge, Equal Rights, Free Schools, Contentment, Love Of Country, Philanthropy, Benevolence, Happiness, Patience, Charity, Faith, Hope, Joy, Industry, Sobriety, Morality, Justice, Virtue, Truth, Honor, Peace, Light, and Immortality. I appreciate the Progressive virtues because of how skew they are to most of the ethical systems I encounter. They’re not leftist (Love Of Country? Industry? Morality?) or rightist (Equal Rights? Free Schools?). They’re not Nietzschean master moralist (Philanthropy? Contentment? Benevolence?) or slave moralist (Industry? Knowledge? Honor?). They’re Christian-ish, but not hair-shirts-and-self-flagellation Christian or God-n-guns-megachurch Christian. They’re the kind of Christians who you can kind of tell are going to end up supporting eugenics in a few years. I think I would classify them as a first-form-slave-morality liberalism, whereas most of the liberalism you encounter these days drifted at least a little into the second form. I’m not 100% on Team Early 20th Century Progressive, but they give me hope that there are weird-yet-coherent groupings of virtues we haven’t even imagined. I feel the same way about some old Soviet posters: These are obviously left-wing, in the sense that they’re literal Communist propaganda. But to the modern eye there’s something off about them, something that makes you want to call them right-wing or even fascist. They’re bold and optimistic. Even though the commissars who commissioned them probably rejected some traditional or capitalist conception of virtue, they still firmly insist that there’s something sort of like virtue or power which is attainable and good. I think these are first-form posters, and that most modern leftism is second-form. I think if you had to group barbarian warlords, Puritans, Soviet communists, and modern leftists on a Nietzschean/geneaological/aesthetic axis, it would go: (Barbarian warlords) | (Puritans, Soviet communists) | (modern leftists) So one very weak compromise - hardly even a compromise, since it predates Nietzsche - is to try to stick with first-form slave morality, in the hopes that most of the problems come from the second. VIII. Ayn Rand “Is Ayn Rand a Nietzschean?”- the greatest thread in the history of forums, locked by a moderator after 12239 pages of heated debate. There’s a real answer here. Rand started out respecting, maybe even loving Nietzsche. She once said that: [Nietzsche’s] Thus Spake Zarathustra is my Bible. I can never commit suicide while I have it. …which maybe reveals more about her psychological situation than I expected from the answer to a “who’s your favorite philosopher” questionnaire. But later on she broke from him. It’s hard to figure out her exact position - she has a bad habit of treating anyone who disagrees with her in any tiny detail as the Antichrist, such that it’s hard to figure out whether she thinks of someone as a 99% fellow traveler or an arch-enemy. Still, there are substantial differences. Nietzsche is more chaotic - he expects the superior man to defy all external rules in favor of his own glorious destiny. But Rand is attached to rules - most of all the epistemic rules of Reason, but also the usual moral tenets like “don’t kill” and “don’t steal”. Nietzsche’s masters take the Ron Swanson approach to justifying their actions: …whereas Rand’s masters are prone to giving twenty-page-long arguments for why whatever they’re doing is the right choice according to Objectively Correct Moral Law. Rand’s approach has lots of advantages. The Nietzschean master, like Andrew Tate, is an awful guy to have around. It’s hard to fit him into a functioning civilization, except maybe an autocracy with him as autocrat. Nietzsche’s pitch is “hey excellent people, you should try to become this guy”, never “hey normal people, you should support my project of creating these guys, out of your own self-interest.” The latter wouldn’t pass the laugh test. Rand’s masters, while still probably very stressful to be around, have been tamed. They follow civilized rules of honesty and nonviolence - not, of course, because they’re too weak to defy them, but because following civilized rules is objectively the coolest thing of all. Instead of competing in battle and leaving a trail of bloody corpses, they compete in Capitalism and leave a trail of high-paying jobs and excellent consumer goods. They’re not doing to serve you - “I should serve the little guy” is slave moralist bulls**t. But, by coincidence, their excellent actions are doing you a service. They might only invent rocket ships to enact their Promethean conquest of nature and prove their own greatness. But you still get to ride in one. Rand also spares more of a thought (or at least an afterthought) for the little guy. Capitalism needs all types - even the company janitor genuinely contributes to whatever glorious accomplishments are going on, and deserves to feel good about themselves. She wants everyone to be the best, most ambitious, and most fighting-for-their-own-aesthetic/moral-vision they can be. But if that means being the company janitor, that’s fine. And if you love rockets and you consummate that love by becoming the janitor for a rocket company, the Objectively Correct Moral Law is 100% on board. I am not a Nietzsche scholar, but I think this is a more productive answer than Nietzsche has for this question. The disadvantage of Rand’s approach compared to Nietzsche’s is that it only works if you believe her proofs about why the Objectively Correct Moral Law is definitely objective and correct - most of which seem to me to be either hand-wavy or balderdash. Otherwise the whole thing breaks down - why is the most masterful thing to be a positive-sum capitalist instead of a negative-sum warlord? Rand really really wants to justify a peaceful, glorious, positive-sum society, to the exact people most capable of benefiting from defecting against it, without bringing in altruism or the common good at any point. It’s an extremely sympathetic goal. But I don’t think she makes it. Still, this is why I’m fond of her. If you really read her books - as opposed to skimming them while subvocalizing “this is that evil woman who loves selfishness” under your breath the whole time - it’s obvious that she believes, with a deep and burning belief, that good things are good. She really really wants to think that you can objectively convince people to support a peaceful, glorious, positive-sum society, without any hint of the psychologically-toxic slave morality that typified the USSR she grew up in. When people react to her books with loathing - without even a hint of fondness - I get suspicious that they’ve gotten so deep into slave morality that thy can’t recognize goodness when it hits them over the head with a sledgehammer. Elsewhere, I wrote: Edward Teach (Sadly, Porn) is famous for making up fake novels to criticize, and it is a little known fact that the "Ayn Rand" character along with all her novels are 100% his work. They operate as a diagnostic test based on his psychodynamic theory of envy. The instrument presents a picture of some exceptional people achieving great things who don't apologize for their greatness, and doesn’t explicitly ask the patient - I mean, reader - for their opinion. If the reader has no strong opinion, or says something like "Good for them, I guess," she passes the test. "I like these people and will use them as a role model" also passes. Some specific criticisms (see below) may also pass. If the reader says "Ah, people who are better than the pathetic sheep around them, just like I'm better than all the pathetic sheep around me!", she . . . still passes the test. That's not what it's testing for! You fail the test if you absolutely freak out about some combination of the Rand characters themselves and the potential existence of arrogant people who identify with the Rand characters. The secret is that it's not a screening test for the kind of people who would get featured on /r/iamverysmart. It's a screening test for the kind of people who would comment on /r/iamverysmart, ie the self-designated Tall Poppy Police, ie the people who build their ego off being the enforcers of the rule that you're not allowed to look better than anyone else. These people's basic mental stance is to hate people who seem too excellent. They don't think of it in these terms. They think of it as calling out arrogance, although if you look too closely you'll find their definition of arrogance covers anyone who seems excellent and but doesn't spend all their time apologizing and abasing themselves and denying it. The brilliance of Teach-Rand is how he-she draws this tendency to the foreground For example, why the whole "Objectivism" thing? Not because value is necessarily completely objective, but because the idea that any value might ever be even partially objective freaks out the Tall Poppy Syndrome people. Mention value at all, and they say you must be trying to secretly smuggle in the assumption that you are more valuable than other people (and therefore you are less valuable than other people, and therefore they are better than you). The same is true of Reason. Mention that Reason exists, and they'll interpret it as a claim that you, the only rational person, are claiming to always be right and infallible. But (they retort) actually nobody knows anything, and the only wise people are the people like them who humbly admit this. (how do you decide what's true without Reason? By bias-based-reasoning - "You say X, but I can imagine a way that would come from a place of believing you're better than other people, therefore, Not-X is true. You say that's a logical fallacy? That must come from a place of believing you're smarter than everyone else and the only person who can use Facts and Logic.") The Teach-Rand test is designed to catch the sort of person who, if someone says that on a right triangle a^2 + b^2 = c^2, responds with "Oh, so you're claiming to be some kind of right triangle expert who's better than the rest of us? You really need to work on that arrogance problem! Super cringe!" Any criticism of the book that doesn't come from this particular place is irrelevant to the test and doesn't count against your grade. (which is good, because the books are bad in a lot of ways. But that's fine - Rorschach blots don't also have to be great art!) Still, I don’t think she’s the superman (superwoman?) who successfully transcends the dichotomy Her philosophy is only as strong as its proofs of Objective Correctness, which I consider weak. Without those, you need some subjective motivation to glue things together - of which altruism is the most popular. But also, don’t we like altruism? When we’re bestriding the Earth like colossi, working on our glorious rocket ships to colonize the universe, isn’t part of what we’re thinking “this is going to revolutionize humankind and make everybody better off?” If you force yourself to reject that motivation, to just repeat “no no no, I’m only doing this because rockets are really big and make cool explosions”, aren’t you cutting out a part of yourself, in exactly the way Nietzschean masters are supposed to try to avoid doing? I find something very compelling about Rand. I think she goes some of the way to answering the Andrew Tate objection to master morality. But she’s a means and not an end. A real superman would have to figure out some way to reintroduce basic human kindness. IX. Matt Yglesias Yglesias’s mantra - “good things are good” - is too perfect and profound to come from anyone other than an esoteric master of Nietzschean philosophy. Good Straussians ignore the title and focus on the subtitle. Nietzsche wrote in the 1890s. There were still real nobles and emperors walking around; communists had not yet started calling capitalism “late capitalism”. Sure, his world was probably some sort of weak compromise between master and slave morality, but it was different from our weak compromise. Our weak compromise was forged through dialogue and warfare with fascism’s novel take on master morality and socialism’s novel take on slave morality. I think of Yglesias - who combines an insistence that good things are good and a proclivity for embiggenment with commitments to democracy, the welfare state, and the poorest among us - as one of its most self-conscious proponents. When I first titled this post, I didn’t know that Richard Hanania had come to the same conclusion and created this face-mash-up of Matt Yglesias and Nietzsche. The compromise goes something like: Everyone is equal before the law, before the metaphorical throne of metaphorical God, and in some poorly defined philosophical sense. This is very important. It’s our headline result. Everything else should be interpreted in light of this central fact.
Inline links: https://substackcdn.com/image/fetch/$s_!6V8D!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F7f1f70cc-b468-4b04-b894-a8b75b3330e5_1024x683.jpeg, https://substackcdn.com/image/fetch/$s_!FF8B!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F0a1ac7aa-d19e-43e8-8462-210325b902be_810x545.png, a real answer here, https://substackcdn.com/image/fetch/$s_!OtNv!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F6ae1aaf2-6cc3-488c-b0a7-5df62eee457b_225x225.jpeg, Elsewhere, Sadly, Porn, /r/iamverysmart, https://substackcdn.com/image/fetch/$s_!MzIr!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Ff03d1a9d-5ffc-45ff-84bc-db3388915bbc_259x390.jpeg, https://substackcdn.com/image/fetch/$s_!hYvV!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fd0f9b152-da12-4525-b062-b4c14d8b8005_383x373.png
Progressivism1 mentions across 1 issues

Progressivism is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between January 04, 2022 and January 04, 2022. The archive places it in contexts such as "Progressivism, like conservatism and every other political philosophy, is big and complicated". It most often appears alongside AGI, America, Asian Scientist.

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Progressivism
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1
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January 04, 2022
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January 04, 2022
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Movie Review: Don't Look Up
January 04, 2022 · Original source
Progressivism, like conservatism and every other political philosophy, is big and complicated and self-contradictory. It tells a lot of stories to define and justify itself. Here are two of them:
Progress™1 mentions across 1 issues

Progress™ is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between April 16, 2021 and April 16, 2021. The archive places it in contexts such as "the name of Progress™". It most often appears alongside "The Rent Is Too Damn High!", 16th amendment, 1886.

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Progress™
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1
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1
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April 16, 2021
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April 16, 2021
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Your Book Review: Progress And Poverty
April 16, 2021 · Original source
The premise of Pixar's movie Up is that Carl Fredricksen, a lovably grumpy pensioner, is the last holdout standing in the way of developers bulldozing the rest of his neighborhood in the name of Progress™. He refuses to sell because he can't bear to part with the house which for him is tied up with all the cherished memories of his departed wife. This isn't just sentimental fiction, this is something that really does happen. Isn't Georgism just going to price the poor Carl Fredricksens out of their homes so that someone with a more """productive""" use can have it instead? There's several good response to this. For starters, if you're worried about kindly old people losing their homes, that's a thing that's happening already, and most of the time it's because The Rent Is Too Damn High, and our existing system is net worse on this score. We are currently facing an unprecedented crisis of evictions in tandem with the COVID pandemic, and it's not like things were peachy before. And even though homelessness seems to be declining in the US overall, it's getting worse in the most prosperous cities, exactly as George predicted. Okay, maybe it's better for renters, but what about people who own their homes, like Carl? Isn't it unfair to stick them with land taxes that might kick them out? What if they're retired? Remember, let's not confuse land tax with land confiscation, Here's George (emphases mine): I do not propose either to purchase or to confiscate private property in land. The first would be unjust; the second, needless. Let the individuals who now hold it still retain, if they want to, possession of what they are pleased to call their land. Let them continue to call it their land. let them buy and sell, and bequeath and devise it. We may safely leave them the shell, if we take the kernel. It is not necessary to confiscate land; it is only necessary to confiscate rent. Okay, but you have to admit that even if the state isn't confiscating everybody's land, if you can't pay your land taxes you have no choice but to sell your land, right? Isn't this morally unjust to the Carl Fredricksens of the world? First, it's not a given that Mr. Fredricksen will be worse off on net: he already pays income and sales taxes, capital gains on any investments, as well as property tax which taxes both land value and the value of his house. As speculators leave the real estate market the land tax that replaces his property tax drop will drop, and his house is an improvement that goes entirely untaxed. Also, if the speculators holding onto all the most valuable real estate in the downtown districts are forced to give it up, there won't be as much competition for land and so there's a good chance developers won't be interested in trying to buy up land in a bedroom community in the first place. BlueRepublik further points out that LVT can be used to fund a Universal Basic Income, which should soften the blow considerably: Keep in mind also that the Georgist Land Value Tax is pair with a "Citizen's Dividend" or what we see as UBI, so that it's not the government claiming land rent, rather the land rent is taxed and split up equally for all men. But as a matter of political practicality, in the rare event that after all that Mr. Fredricksen still somehow finds himself in the hole after LVT is applied, Nate Blair suggests a deferment option to grandfather the Carls of the world through the transition: The LVT gets assessed annually for everyone, but owner occupiers (businesses and homeowners) can apply to defer the sum of those payments until they sell or transfer the land. Government can charge a nominal interest. A final point of modern application of land value taxes is to level the playing field between different areas by eliminating "cost of living" discrepancies that arise entirely from speculative rent. This is pretty relevant given the "location pay" debate going on in Silicon Valley right now in response to increased remote work as a direct consequence of the COVID pandemic. Back to George. Great, we've taxed ground rent at 100% and eliminated speculation and all other manner of social ills. Now what do we do with the money? Lots of things! For one, you can get rid of some other taxes. Back in George's day it was even argued that a 100% land value tax on ground rents should be the only tax – the "Single Tax," replacing all other tariffs, duties, and other taxes (keep in mind this was in the late 1800's and Federal income tax wasn't introduced until the 16th amendment in 1913). Remember, all these other taxes have deadweight loss. Income tax is a tax on labor, and so taxing it means we really do get less productive labor. The portion of property tax that targets improvements punishes you for investing in improvements, and sales tax is just straight up regressive, hitting the poor harder than the rich. There's some argument today about whether the "Single Tax" would be enough to fund the modern US budget, with some Georgists saying it would be sufficient and others saying we would still need some other taxes but could at least significantly offset what we already have. But by George, another thing we could do is just give all the money back to the people, as BlueRepublik mentioned above. This could be used as a straightforward Universal Basic Income – what George calls a Citizen's Dividend, or what Andrew Yang calls the Freedom Dividend. It could also be used for the funding of public goods. George doesn't see this as an act of charity on the state's behalf – the value of the land has its origin in the productive labors of the entire community, so it's a simple act of justice to give the returns to those who actually produced the value, which is society at large. Another effect George asserts is that once land is no longer monopolized, labor is no longer forced into one-sided competition, so wages start to go up. Even better, laborers now have far more opportunity to go into business for themselves, which spurs innovation and investment. So to sum up, if we tax the ever loving hell out of ground rent, George says we'll see the following benefits: Make housing much more affordable
Inline links: https://substackcdn.com/image/fetch/$s_!G2qa!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2Fa948c9cc-5271-4b71-8c74-de55e126f16a_640x360.png, really does happen, crisis of evictions, getting worse in the most prosperous cities, "location pay" debate going on in Silicon Valley, Citizen's Dividend, the Freedom Dividend
Prohibition-Era1 mentions across 1 issues

Prohibition-Era is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between February 20, 2021 and February 20, 2021. The archive places it in contexts such as "fashionable gangsters holed up in a ritzy Prohibition-Era warehouse". It most often appears alongside Archangel Gabriel, Army Of Public Works, Bonus Army.

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Prohibition-Era
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1
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1
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February 20, 2021
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February 20, 2021
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Movie Review: Gabriel Over The White House
February 20, 2021 · Original source
People who should watch this movie: anyone who wants to see a completely innocent defense of dictatorship, written by people unaware it could go badly. Anyone who doubts that FDR surfed into power on a wave of fascism. Anyone who wants to see a shootout between blocky 1930s tanks under the command of the President's personal secretary vs. fashionable gangsters holed up in a ritzy Prohibition-Era warehouse. Anyone who enjoys crazy stuff which follows its own logic without compromise. Anyone who want to see how a truly excellent and talented actor portrays Franklin Roosevelt possessed by an archangel.
Project 20251 mentions across 1 issues

Project 2025 is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between March 03, 2026 and March 03, 2026. The archive places it in contexts such as "his previous denial of Project 2025 makes this less reassuring". It most often appears alongside 2024 US election, 2026 elections, Agent Economy Of The Future.

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Project 2025
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1
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1
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March 03, 2026
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March 03, 2026
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Mantic Monday: Groundhog Day
March 03, 2026 · Original source
At the same time, there are rumors that the Trump administration is working on an executive order to declare a national emergency and take control of elections. The order would say that foreign countries have been rigging US elections (some commenters speculate that maybe Maduro could be granted clemency for “admitting” to this), and respond with a series of extreme measures. These would include banning voting machines, restricting vote-by-mail, and requiring all voters to re-register before the election. For what it’s worth, Trump has denied all of this, although his previous denial of Project 2025 makes this less reassuring.
Inline links: an executive order, denied all of this
Project Apollo1 mentions across 1 issues

Project Apollo is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between December 09, 2022 and December 09, 2022. The archive places it in contexts such as "if we mean Project Apollo and such, it was nuclear weapons and the V-2". It most often appears alongside 417th Marquess of Cornwallshireshire, ACX, ACX.

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Project Apollo
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1
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1
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December 09, 2022
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December 09, 2022
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Highlights From The Comments On Bobos In Paradise
December 09, 2022 · Original source
I think there's some merit in what you say, but it wasn't the space race per se, if we mean Project Apollo and such, it was nuclear weapons and the V-2, because those happened in 1945 and the Space Race got started later (and for that matter, a significant motivation in the Space Race was the fear of The Best And The Brightest that Soviet missile technology would surpass the USAF as a strategic threat multiplier).
Project Xanadu1 mentions across 1 issues

Project Xanadu is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between September 19, 2025 and September 19, 2025. The archive places it in contexts such as "Nelson claims to have called Vannevar Bush and told him about Project Xanadu"; "Ted Nelson had built Project Xanadu into, for lack of better terminology, a cult"; "while staring unblinkingly at the words Project Xanadu". It most often appears alongside 1987, 1988, Adleman.

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Project Xanadu
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1
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1
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September 19, 2025
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September 19, 2025
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Your Review: Project Xanadu - The Internet That Might Have Been
September 19, 2025 · Original source
compilable "Command Meta Language" Live on stage, in the year 1968, Engelbart started up the NLS, opened a document, and typed some words into it. The words, he said, constituted a statement. And statements made up a file. Engelbart copied, manipulated, saved, and loaded his words and statements and files, zipping around with his newly-invented mouse. He demonstrated his ability to embed documents in one another—images with links to statements, words nested and categorized by one another, files filled with metadata. And then he paused, and the screen went blank. He explained that he and his colleagues at the ARC had been using this system to do their daily work for the last six months. He mentioned that they had, now, six consoles up and running. He showed the crowd a real document, then navigated to a statement within it. “This presentation is devoted to the AHIRC.” “What is the AHIRC?” he asked. Engelbart “froze” the initial statement, clicked on the acronym, and below the words “Augmented-Human-Intellect Research Center” appeared. He kept clicking and freezing, and a trail of nested and related information appeared—a list of funders, a graph of staffing over time, a mission statement. This was hypermedia. These were hyperlinks, he explained. NLS was a hypertext system. The presentation went on for 90 minutes longer, and became known as The Mother of All Demos.2 At around the 75-minute mark, Engelbart shows that two different NLS users could edit a single document simultaneously. While this was extremely impressive functionality, it was achieved with time-sharing—computation was done on a single machine, switching rapidly between tasks—and became infeasible the very next year, when ARPANET was released and the number of machines you could connect to one system grew rapidly. Engelbart’s hypertext system was impressive in its own right, even without collaborativity. And still, little came of it—Andy van Dam, an attendee and revolutionary computer scientist himself, would reflect decades later: “Everybody was blown away … and nothing else happened. There was almost no further impact.” Engelbart’s ideas were just a little too out there. ARC quickly faded into obscurity. In 1972, Engelbart joined an organization called Erhard Seminars Training. EST, or “est” as it was marketed, offered a 60-hour self-improvement course for tech entrepreneurs modeled loosely on Zen Buddhism. Critics suggested that the est course was a mind-control method aimed at raising an authoritarian army. It was quite credibly branded a cult. The founder of est, Werner Erhard, was accused of tax fraud (he fought the claims and won $200,000 from the IRS) and incest (by his daughter, who later recanted). Engelbart served, for many years, on est’s board of directors. His researchers all left for greener, less cult-y pastures, and ARC died with hardly a whimper. No one really wanted to associate with Engelbart. His crackpot theories about an internet modeled after the memex fell into disrepute, and, if he was remembered at all, it was for the invention of the mouse. No one cared anymore about the memex, or hypertext. 3. Hyper-dreams of Hyper-everything Well, one man cared. Ted Nelson was born in 1937 to two twenty-year-olds, Ralph Nelson and Celeste Holm. His parents divorced in 1939, leaving him to be raised by his grandparents. Both Nelson (the elder) and Holm would go on to extremely-successful film careers: the former became an Emmy-winning director; the latter an Oscar-winning actress. And, at first, Ted seemed to be following in their footsteps. As a philosophy major at Swarthmore College, he produced a film called The Epiphany of Slocum Furlow, which he described as “a short comedy about loneliness at college and the meaning of life.”3 Nelson also claims to have “[d]irected [and written] book and lyrics for what was apparently the first rock musical” in his junior year at Swarthmore. Thankfully, his interest in a career as an entertainer soon waned, and Nelson went off to study sociology in grad school—first at the University of Chicago, then at Harvard. Nelson took a computer class at Harvard, in 1960, and “[his] world exploded.”4 He realized the incredible power of computing, quickly intuited that these new machines could be generally applied to everything, and founded Project Xanadu.5 Initially, Xanadu’s scope was pretty limited. Word processors weren’t around yet, but Nelson wanted to build something strikingly similar: he wanted to write a program that could store and display documents, with version histories and edits all stored and displayed at the same time too. Later, Nelson would call this version-history feature “intercomparison.” (Strange coinages will be a… theme; I’m just trying to get you ready.) Nelson began working on an implementation, but his feature wishlist grew quickly, and he didn’t really know what he was doing, so in 1965, he sought help. He prepared a talk for the Association for Computing Machinery, and dropped, quite frankly, a bomb on the audience: The kinds of file structures required if we are to use the computer for personal files and as an adjunct to creativity are wholly different in character from those customary in business and scientific data processing. They need to provide the capacity for intricate and idiosyncratic arrangements, total modifiability, undecided alternatives, and thorough internal documentation. The original idea was to make a file for writers and scientists, much like the personal side of Bush's Memex, that would do the things such people need with the richness they would want. But there are so many possible specific functions that the mind reels. These uses and considerations become so complex that the only answer is a simple and generalized building-block structure, user-oriented and wholly general-purpose. The resulting file structure is explained and examples of its use are given. Ted Nelson was building the memex. Of course, he wasn’t a very technical guy, and so his talk mostly focused on the philosophy of Xanadu, not its implementation. He commented (emphasis mine): There are three false or inadequate theories of how writing is properly done. The first is that writing is a matter of inspiration. While inspiration is useful, it is rarely enough in itself. “Writing is 10% inspiration, 90% perspiration,” is a common saying. But this leads us to the second false theory, that “writing consists of applying the seat of the pants to the seat of the chair.” Insofar as sitting facilitates work, this view seems reasonable, but it also suggests that what is done while sitting is a matter of comparative indifference; probably not. The third false theory is that all you really need is a good outline, created on prior consideration, and that if the outline is correctly followed the required text will be produced. For most good writers this theory is quite wrong. Rarely does the original outline predict well what headings and sequence will create the effects desired: the balance of emphasis, sequence of interrelating points, texture of insight, rhythm, etc. We may better call the outlining process inductive: certain interrelations appear to the author in the material itself, some at the outset and some as he works. He can only decide which to emphasize, which to use as unifying ideas and principles, and which to slight or delete, by trying. Outlines in general are spurious, made up after the fact by examining the segmentation of a finished work. If a finished work clearly follows an outline, that outline probably has been hammered out of many inspirations, comparisons and tests. Between the inspirations, then, and during the sitting, the task of writing is one of rearrangement and reprocessing, and the real outline develops slowly. The original crude or fragmentary texts created at the outset generally undergo many revision processes before they are finished. Intellectually they are pondered, juxtaposed, compared, adapted, transposed, and judged; mechanically they are copied, overwritten with revision markings, rearranged and copied again. This cycle may be repeated many times. The whole grows by trial and error in the processes of arrangement, comparison and retrenchment. Nelson recognized that the creation of knowledge is cyclical, recursive, self-referential. And he figured that our computer systems should accept and reflect that process: If a writer is really to be helped by an automated system, it ought to do more than retype and transpose: it should stand by him during the early periods of muddled confusion, when his ideas are scraps, fragments, phrases, and contradictory overall designs. And it must help him through to the final draft with every feasible mechanical aid—making the fragments easy to find, and making easier the tentative sequencing and juxtaposing and comparing. How do you design such a system? To navigate intuitively within complex file systems, between document versions, and across source materials—to access all the scraps and fragments writers need to write—you would need to establish what Vannevar Bush called “tracks.” You would need to connect and save different ideas, linking them together. That was it—you needed links. Nelson went further, though—it wouldn’t do to simply have links to all the other files, a writer needed to see the other files before him, needed them to be brought up and displayed alongside his current work on demand. The links needed to contain their targets within themselves—so Nelson called them hyperlinks. And he called text embedded with hyperlinks hypertext, and movies embedded in his structure became hyperfilms, and so on. Nelson wanted us using computers to write and create self-referential, intricately-interconnected (“intertwingled,” as he’d later put it), eminently-accessible hypermedia. And recall, in 1965, state-of-the-art computing looked like this. Ted Nelson was thinking far, far ahead. Maybe too far ahead. Conference attendees were initially excited about his idea, but when he revealed himself to know very little about the technical task of building Xanadu—or even whether it was possible at all—interest evaporated. 4. Failing to Develop Xanadu But Nelson was all in. He would later write, “This is not a technical issue, but rather moral, aesthetic and conceptual.” Nelson loved knowledge and connection and abstraction—mere technical details wouldn’t stop him from building the best possible computer system for producing and consuming information. He met Doug Engelbart in the mid 60s, forming a friendship with the only other man taking hypertext seriously at the time, and hopped around unhappily between various academic and scientific appointments. At one point, he and Andy van Dam worked together and produced the Hypertext Editing System—released in 1967, just before Engelbart’s NLS. It was the first computer application to ever have an “undo” button—Nelson claims to this day that he invented it (and the “back” button). Shortly thereafter, Nelson’s wife left him. In his 2010 autobiography, he writes, “She, reasonably, wanted a Nice Life; women want that sort of thing.” They had a son, whom Nelson continued to visit regularly. “Debbie has been a friend and great support all these years,” Nelson adds. “[S]he believed in me.” Nelson gave a talk at Union Theological Seminary in 1968 that included this slide, which Nelson considers “the first depiction of what the personal computer turned out to be.” “About six years later they started building computers like this at Xerox PARC.” Around the same time, Nelson claims to have called Vannevar Bush and told him about Project Xanadu. Bush “wanted very much to discuss it with” Nelson, but Nelson “hated him instantly [because] he sounded like a sports coach” and never contacted him again. This, of course, proved to be extremely self-destructive (though I can’t honestly say I would’ve done otherwise). Because Xanadu was as good as dead. No one would give him the money he needed to work on it, especially not after Doug Engelbart poisoned the idea of hypertext. Nelson went where there was funding, working briefly on an early word processor called Juggler of Text (JOT). …And then he lost investment, stopped working on the project, and moved to Chicago, where he’d been offered a job teaching at the University of Illinois, to start work on a book. He would call it Computer Lib. In fact, he started work on another book at the same time, called Dream Machines. By the time he completed each of them, in 1974, ARPANET had been released, and his vision for Project Xanadu had evolved. He published the two works together—Computer Lib was his lamentation over the industry’s disdain for hypertext, and Dream Machines was Xanadu’s manifesto. Nelson designed and printed the book himself. Its pages mostly look like this: Self-referential, multimedia, creative, and fun—they were a blueprint for the internet he was building. In the Dream Machines half, Nelson writes, “The real dream is for ‘everything’ to be in the hypertext. Everything you read, you read from the screen (and can always get back to right away; everything you write, you write at the screen (and can cross-link to whatever you read).” In one section Nelson asks himself, “Can It Be Done?” His answer: “I dunno.” Remember, Xanadu wouldn’t only involve links between works—it required hyperlinks, which as Nelson understood them, would need to contain the targets in themselves. (Eventually, Nelson would give these embeddings a new name—“transclusions”—and hyperlink came to simply mean “link between hypertext files.”) Every link would run both ways, each hypertext file would know exactly which other files were linked to it and how. This introduced a few problems, in the new interconnected ARPANET age: How do you keep track? Where’s the metadata stored? Can you afford enough space for it all?
Inline links: 2, would reflect, 3, claims, 4, 5, https://substackcdn.com/image/fetch/$s_!wpPj!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fda43a667-c15b-4626-a0a7-480ad1144dce_1114x1070.jpeg, https://substackcdn.com/image/fetch/$s_!Y2jg!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F96fdc6cc-8ead-4aef-9539-fa421e77c0f9_1600x1299.png, https://substackcdn.com/image/fetch/$s_!kp4P!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Ff55d10e8-ef84-43a9-9f39-422d87ea182e_1600x952.png
“About six years later they started building computers like this at Xerox PARC.” Around the same time, Nelson claims to have called Vannevar Bush and told him about Project Xanadu. Bush “wanted very much to discuss it with” Nelson, but Nelson “hated him instantly [because] he sounded like a sports coach” and never contacted him again. This, of course, proved to be extremely self-destructive (though I can’t honestly say I would’ve done otherwise). Because Xanadu was as good as dead. No one would give him the money he needed to work on it, especially not after Doug Engelbart poisoned the idea of hypertext. Nelson went where there was funding, working briefly on an early word processor called Juggler of Text (JOT). …And then he lost investment, stopped working on the project, and moved to Chicago, where he’d been offered a job teaching at the University of Illinois, to start work on a book. He would call it Computer Lib. In fact, he started work on another book at the same time, called Dream Machines. By the time he completed each of them, in 1974, ARPANET had been released, and his vision for Project Xanadu had evolved. He published the two works together—Computer Lib was his lamentation over the industry’s disdain for hypertext, and Dream Machines was Xanadu’s manifesto. Nelson designed and printed the book himself. Its pages mostly look like this: Self-referential, multimedia, creative, and fun—they were a blueprint for the internet he was building. In the Dream Machines half, Nelson writes, “The real dream is for ‘everything’ to be in the hypertext. Everything you read, you read from the screen (and can always get back to right away; everything you write, you write at the screen (and can cross-link to whatever you read).” In one section Nelson asks himself, “Can It Be Done?” His answer: “I dunno.” Remember, Xanadu wouldn’t only involve links between works—it required hyperlinks, which as Nelson understood them, would need to contain the targets in themselves. (Eventually, Nelson would give these embeddings a new name—“transclusions”—and hyperlink came to simply mean “link between hypertext files.”) Every link would run both ways, each hypertext file would know exactly which other files were linked to it and how. This introduced a few problems, in the new interconnected ARPANET age: How do you keep track? Where’s the metadata stored? Can you afford enough space for it all?
Inline links: https://substackcdn.com/image/fetch/$s_!kp4P!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Ff55d10e8-ef84-43a9-9f39-422d87ea182e_1600x952.png
Eric Hill, a 15-year-old hacker and indicted felon, who “had been dismissed by the judge with admiration.” In Swarthmore, Nelson hoped his decades-old dream of Xanadu would finally materialize. 5. Developing Xanadu Ted Nelson had built Project Xanadu into, for lack of better terminology, a cult.8 He writes: We all were deeply concerned about the Bad Guys, who we saw as a combination of IBM and the government. (The others were all Libertarians, I still called myself a Cynical Socialist.) The Bad Guys would spy on people, withhold and block information, and give us inferior hypertext. We had to Do It Right, to help prevent this. This meant using the standard business defenses—especially non-disclosure agreements (I made all of them sign) and secret proprietary algorithms. The Xanadians had a messiah—Ted Nelson—a gospel—Computer Lib—a persecution complex, a fearful dystopia—“inferior hypertext”—a hopeful utopia—Xanadu—and utter secrecy. Just six dudes in a rented house near Philly, building the internet, hiding from the Feds, signing NDAs, and saving the world. Nelson spent a summer explaining the project to his team in its entirety. By the end, Gregory, Miller, and Greene were the only ones left. They told Nelson, “We’ll do it,” and moved to another suburb, where they finally began to work on an implementation of Xanadu. The three quickly figured out a new system that would allow users to reference and link to specific parts of a file—they called these links tumblers, and made them work with transfinite numbers. Suddenly, transclusions were really possible. But after only a few early successes, the team’s progress stalled completely. Greene and Miller were young and left for jobs elsewhere, and so Gregory was left working on Xanadu alone. Nelson, meanwhile, ran a magazine called Creative Computing for a while, then tried again to build his JOT word processor—this time for the Apple II—then spent a year in San Antonio pitching a watered-down version of Xanadu (rebranded as “Vortext”) to a tech company called Datapoint. Datapoint wasn’t buying, but kept Nelson on in some sort of fake, primitive email job anyway. Gregory kept working on Xanadu in Philadelphia, slowly running out of money. Ted Nelson held an “Ecstasy party” in San Antonio: “A number of us floated down the river on inner tubes. It was quite lovely.” In 1987, like he did every year, Roger Gregory went to The Hackers Conference in Saratoga to show off the latest unimpressive version of Xanadu. There, he met a man named John Walker—founder of the wildly successful Autodesk—and pitched the project to him. Incredibly, Walker was interested, and after tense negotiations with Nelson, agreed to fund Xanadu in earnest. Beginning in 1988, Autodesk poured millions of dollars into the project, and a programming team led by Gregory finally started to make real progress. Walker said of Xanadu: “In 1980, it was the shared goal of a small group of brilliant technologists. By 1989, it will be a product. And by 1995, it will begin to change the world.” Sweeping rhetoric—clear deadlines. The team came nowhere close to meeting them. Infighting broke out between two factions—while Gregory simply wanted to patch together his old C code, insisting his product “was within six months of shipping,” the whiz-kid Mark Miller came back from his new job at Xerox PARC, alongside a half-dozen of his closest friends, and insisted on a perfectionistic rewrite in a more flexible language, Smalltalk. The PARC faction began to drive Gregory up the wall. According to Nelson, it got to the point that he “was throwing things and acting crazy.” So Nelson called John Walker, the two “summoned Roger to meet [them] at John’s house at Muir Beach, and Walker told Roger he was no longer in charge.” Miller took over and began the rewrite in Smalltalk. Walker’s deadline came and went, and the team delivered nothing. Xanadu’s offices descended into chaos—Miller anointed two PARC programmers to be “co-architects,” and the three of them increasingly left the rest of the team out of the loop. For four years, Miller dawdled about, adding features, giving them clever names (files were “berts,” after Bertrand Russell, and so, for symmetry’s sake, royalty-generating transclusions became “ernies”), and never building them.9 Meanwhile, Ted Nelson was living on a houseboat, attending sex retreats and Keristan orgies, and giving talks in Singapore. He recorded a new soundtrack for his student film, the one from 1959. In 1992, Autodesk’s stock cratered, and they divested entirely from Xanadu. Miller lamented that his program was just six months from completion. Ted Nelson started a film studio to make a movie with Doug Engelbart, then left for Japan to get a PhD. Xanadu’s code was open-sourced in the late 90s. 6. The World Wide Web In March 1989, a British computer scientist named Tim Berners-Lee, working at CERN, wrote a proposal for a system unifying hypertext and the internet. It was ignored. In 1990, Berners-Lee resubmitted his proposal, it was accepted, and he began to work on the World Wide Web. The WWW had a number of advantages over Xanadu: It was much simpler—Ted Nelson wrote of it disparagingly: “Where were annotation and marginal notes? Where was version management? Where was rights management? Where were multi-ended links? Where were third-party links? Where were transclusions? This ‘World Wide Web’ was just a lame text format and a lot of connected directories.” As it turns out, it’s much easier to build a lame text format and a lot of connected directories!
Inline links: 8, 9, Keristan
proles1 mentions across 1 issues

proles is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between May 23, 2024 and May 23, 2024. The archive places it in contexts such as "It divided people into Inner Party, Outer Party, and proles". It most often appears alongside 1984, 1984 Calendar Meme, ACX.

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proles
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1
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1
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May 23, 2024
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May 23, 2024
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A Theoretical "Case Against Education"
May 23, 2024 · Original source
(full list of things I remember about 1984: the author was George Orwell. There were three countries called Eurasia, Eastasia, and Oceania. Britain was part of Eurasia and called “Airstrip One”. Every so often the countries would shift alliances, and the government would lie and say “we have always been at war with Eastasia”. There was an evil totalitarian government with a possibly-fake leader named Big Brother, and a possibly-fake rebel with a Jewish-sounding name. It divided people into Inner Party, Outer Party, and proles. There was a language called “Newspeak” with neologisms like “doubleplusgood” that made it hard to question authority. There were characters named Winston and Julia. Winston sort of tried to be against the evil government; he got tortured through some horrifying thing involving rats; at the end he said he loved Big Brother and 2+2=5. Something was weird about Julia and maybe she was an agent of the evil government or something. I think these are all facts that I might encounter in the wild once every few years.)
proletarian1 mentions across 1 issues

proletarian is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between December 04, 2024 and December 04, 2024. The archive places it in contexts such as "a faux-proletarian idea of simplicity and scientificness". It most often appears alongside 3D printing, Abercrombie & Fitch, AI.

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proletarian
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1
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1
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December 04, 2024
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December 04, 2024
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Book Review: From Bauhaus To Our House
December 04, 2024 · Original source
Wolfe ties this to the contemporaneous rise of pop art. Modern art and architecture were founded in the rejection of bourgeois notions of beauty, in favor of a faux-proletarian idea of simplicity and scientificness. But, Venturi pointed out, proletarians were kind hard to find in c. 1970 America. Grounding your class analysis in a non-existent proletariat seemed kind of out-of-touch, and so - perhaps - bourgeois. Who actually existed? The middle class. And what did the middle class like? Mass market consumer slop. Therefore, the true foundation of Art should be mass market consumer slop. Of course, since artists are superior to the middle class, it should be some sort of extremely complicated reference to mass market consumer slop which makes it clear that the artist themselves is infinitely above such things (but also, what if they weren’t above it, because they were so in-touch with normal people (but also, obviously they’re infinitely above it (but also, what if they weren’t))) . . . and so on. This tendency eventually became postmodernism with all its layers of irony and self-reference.
Promethean conquest of nature1 mentions across 1 issues

Promethean conquest of nature is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between July 30, 2024 and July 30, 2024. The archive places it in contexts such as "Might only invent rocket ships to enact their Promethean conquest of nature". It most often appears alongside /r/iamverysmart, 4chan, Achilles.

Mention count
1
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1
First seen
July 30, 2024
Last seen
July 30, 2024
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Matt Yglesias Considered As The Nietzschean Superman
July 30, 2024 · Original source
These are obviously left-wing, in the sense that they’re literal Communist propaganda. But to the modern eye there’s something off about them, something that makes you want to call them right-wing or even fascist. They’re bold and optimistic. Even though the commissars who commissioned them probably rejected some traditional or capitalist conception of virtue, they still firmly insist that there’s something sort of like virtue or power which is attainable and good. I think these are first-form posters, and that most modern leftism is second-form. I think if you had to group barbarian warlords, Puritans, Soviet communists, and modern leftists on a Nietzschean/geneaological/aesthetic axis, it would go: (Barbarian warlords) | (Puritans, Soviet communists) | (modern leftists) So one very weak compromise - hardly even a compromise, since it predates Nietzsche - is to try to stick with first-form slave morality, in the hopes that most of the problems come from the second. VIII. Ayn Rand “Is Ayn Rand a Nietzschean?”- the greatest thread in the history of forums, locked by a moderator after 12239 pages of heated debate. There’s a real answer here. Rand started out respecting, maybe even loving Nietzsche. She once said that: [Nietzsche’s] Thus Spake Zarathustra is my Bible. I can never commit suicide while I have it. …which maybe reveals more about her psychological situation than I expected from the answer to a “who’s your favorite philosopher” questionnaire. But later on she broke from him. It’s hard to figure out her exact position - she has a bad habit of treating anyone who disagrees with her in any tiny detail as the Antichrist, such that it’s hard to figure out whether she thinks of someone as a 99% fellow traveler or an arch-enemy. Still, there are substantial differences. Nietzsche is more chaotic - he expects the superior man to defy all external rules in favor of his own glorious destiny. But Rand is attached to rules - most of all the epistemic rules of Reason, but also the usual moral tenets like “don’t kill” and “don’t steal”. Nietzsche’s masters take the Ron Swanson approach to justifying their actions: …whereas Rand’s masters are prone to giving twenty-page-long arguments for why whatever they’re doing is the right choice according to Objectively Correct Moral Law. Rand’s approach has lots of advantages. The Nietzschean master, like Andrew Tate, is an awful guy to have around. It’s hard to fit him into a functioning civilization, except maybe an autocracy with him as autocrat. Nietzsche’s pitch is “hey excellent people, you should try to become this guy”, never “hey normal people, you should support my project of creating these guys, out of your own self-interest.” The latter wouldn’t pass the laugh test. Rand’s masters, while still probably very stressful to be around, have been tamed. They follow civilized rules of honesty and nonviolence - not, of course, because they’re too weak to defy them, but because following civilized rules is objectively the coolest thing of all. Instead of competing in battle and leaving a trail of bloody corpses, they compete in Capitalism and leave a trail of high-paying jobs and excellent consumer goods. They’re not doing to serve you - “I should serve the little guy” is slave moralist bulls**t. But, by coincidence, their excellent actions are doing you a service. They might only invent rocket ships to enact their Promethean conquest of nature and prove their own greatness. But you still get to ride in one. Rand also spares more of a thought (or at least an afterthought) for the little guy. Capitalism needs all types - even the company janitor genuinely contributes to whatever glorious accomplishments are going on, and deserves to feel good about themselves. She wants everyone to be the best, most ambitious, and most fighting-for-their-own-aesthetic/moral-vision they can be. But if that means being the company janitor, that’s fine. And if you love rockets and you consummate that love by becoming the janitor for a rocket company, the Objectively Correct Moral Law is 100% on board. I am not a Nietzsche scholar, but I think this is a more productive answer than Nietzsche has for this question. The disadvantage of Rand’s approach compared to Nietzsche’s is that it only works if you believe her proofs about why the Objectively Correct Moral Law is definitely objective and correct - most of which seem to me to be either hand-wavy or balderdash. Otherwise the whole thing breaks down - why is the most masterful thing to be a positive-sum capitalist instead of a negative-sum warlord? Rand really really wants to justify a peaceful, glorious, positive-sum society, to the exact people most capable of benefiting from defecting against it, without bringing in altruism or the common good at any point. It’s an extremely sympathetic goal. But I don’t think she makes it. Still, this is why I’m fond of her. If you really read her books - as opposed to skimming them while subvocalizing “this is that evil woman who loves selfishness” under your breath the whole time - it’s obvious that she believes, with a deep and burning belief, that good things are good. She really really wants to think that you can objectively convince people to support a peaceful, glorious, positive-sum society, without any hint of the psychologically-toxic slave morality that typified the USSR she grew up in. When people react to her books with loathing - without even a hint of fondness - I get suspicious that they’ve gotten so deep into slave morality that thy can’t recognize goodness when it hits them over the head with a sledgehammer. Elsewhere, I wrote: Edward Teach (Sadly, Porn) is famous for making up fake novels to criticize, and it is a little known fact that the "Ayn Rand" character along with all her novels are 100% his work. They operate as a diagnostic test based on his psychodynamic theory of envy. The instrument presents a picture of some exceptional people achieving great things who don't apologize for their greatness, and doesn’t explicitly ask the patient - I mean, reader - for their opinion. If the reader has no strong opinion, or says something like "Good for them, I guess," she passes the test. "I like these people and will use them as a role model" also passes. Some specific criticisms (see below) may also pass. If the reader says "Ah, people who are better than the pathetic sheep around them, just like I'm better than all the pathetic sheep around me!", she . . . still passes the test. That's not what it's testing for! You fail the test if you absolutely freak out about some combination of the Rand characters themselves and the potential existence of arrogant people who identify with the Rand characters. The secret is that it's not a screening test for the kind of people who would get featured on /r/iamverysmart. It's a screening test for the kind of people who would comment on /r/iamverysmart, ie the self-designated Tall Poppy Police, ie the people who build their ego off being the enforcers of the rule that you're not allowed to look better than anyone else. These people's basic mental stance is to hate people who seem too excellent. They don't think of it in these terms. They think of it as calling out arrogance, although if you look too closely you'll find their definition of arrogance covers anyone who seems excellent and but doesn't spend all their time apologizing and abasing themselves and denying it. The brilliance of Teach-Rand is how he-she draws this tendency to the foreground For example, why the whole "Objectivism" thing? Not because value is necessarily completely objective, but because the idea that any value might ever be even partially objective freaks out the Tall Poppy Syndrome people. Mention value at all, and they say you must be trying to secretly smuggle in the assumption that you are more valuable than other people (and therefore you are less valuable than other people, and therefore they are better than you). The same is true of Reason. Mention that Reason exists, and they'll interpret it as a claim that you, the only rational person, are claiming to always be right and infallible. But (they retort) actually nobody knows anything, and the only wise people are the people like them who humbly admit this. (how do you decide what's true without Reason? By bias-based-reasoning - "You say X, but I can imagine a way that would come from a place of believing you're better than other people, therefore, Not-X is true. You say that's a logical fallacy? That must come from a place of believing you're smarter than everyone else and the only person who can use Facts and Logic.") The Teach-Rand test is designed to catch the sort of person who, if someone says that on a right triangle a^2 + b^2 = c^2, responds with "Oh, so you're claiming to be some kind of right triangle expert who's better than the rest of us? You really need to work on that arrogance problem! Super cringe!" Any criticism of the book that doesn't come from this particular place is irrelevant to the test and doesn't count against your grade. (which is good, because the books are bad in a lot of ways. But that's fine - Rorschach blots don't also have to be great art!) Still, I don’t think she’s the superman (superwoman?) who successfully transcends the dichotomy Her philosophy is only as strong as its proofs of Objective Correctness, which I consider weak. Without those, you need some subjective motivation to glue things together - of which altruism is the most popular. But also, don’t we like altruism? When we’re bestriding the Earth like colossi, working on our glorious rocket ships to colonize the universe, isn’t part of what we’re thinking “this is going to revolutionize humankind and make everybody better off?” If you force yourself to reject that motivation, to just repeat “no no no, I’m only doing this because rockets are really big and make cool explosions”, aren’t you cutting out a part of yourself, in exactly the way Nietzschean masters are supposed to try to avoid doing? I find something very compelling about Rand. I think she goes some of the way to answering the Andrew Tate objection to master morality. But she’s a means and not an end. A real superman would have to figure out some way to reintroduce basic human kindness. IX. Matt Yglesias Yglesias’s mantra - “good things are good” - is too perfect and profound to come from anyone other than an esoteric master of Nietzschean philosophy. Good Straussians ignore the title and focus on the subtitle. Nietzsche wrote in the 1890s. There were still real nobles and emperors walking around; communists had not yet started calling capitalism “late capitalism”. Sure, his world was probably some sort of weak compromise between master and slave morality, but it was different from our weak compromise. Our weak compromise was forged through dialogue and warfare with fascism’s novel take on master morality and socialism’s novel take on slave morality. I think of Yglesias - who combines an insistence that good things are good and a proclivity for embiggenment with commitments to democracy, the welfare state, and the poorest among us - as one of its most self-conscious proponents. When I first titled this post, I didn’t know that Richard Hanania had come to the same conclusion and created this face-mash-up of Matt Yglesias and Nietzsche. The compromise goes something like: Everyone is equal before the law, before the metaphorical throne of metaphorical God, and in some poorly defined philosophical sense. This is very important. It’s our headline result. Everything else should be interpreted in light of this central fact.
Inline links: a real answer here, https://substackcdn.com/image/fetch/$s_!OtNv!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F6ae1aaf2-6cc3-488c-b0a7-5df62eee457b_225x225.jpeg, Elsewhere, Sadly, Porn, /r/iamverysmart, https://substackcdn.com/image/fetch/$s_!MzIr!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Ff03d1a9d-5ffc-45ff-84bc-db3388915bbc_259x390.jpeg, https://substackcdn.com/image/fetch/$s_!hYvV!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fd0f9b152-da12-4525-b062-b4c14d8b8005_383x373.png
Prop 131 mentions across 1 issues

Prop 13 is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between January 06, 2026 and January 06, 2026. The archive places it in contexts such as "they all hate Prop 13". It most often appears alongside @docneto, Americans, Andy G.

Reference entry
Prop 13
Mention count
1
Issue count
1
First seen
January 06, 2026
Last seen
January 06, 2026
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Highlights From The Comments On Boomers
January 06, 2026 · Original source
And I feel nervous because I’m neutralish on something where there’s basically a unanimous consensus of smart people (they all hate Prop 13), but to me it does seem to make sense that rising house values shouldn’t be able to make your current home unaffordable - both because as someone in a state where house values have pentupled in a generation this seems like a recipe for constant forced upheaval, stress, and destruction of families/community, and because it gives NIMBYs one more reason to oppose density (if someone upzones your area, that increases the value of your land, and therefore your property taxes, and might force you to leave your house - therefore, you should fight upzoning unless you want to be forced out).
The most important thing I got from these interactions was learning about the proposal to keep property taxes high, but delay them until death/sale of property. This relieves some of my tension around Prop 13 and related issues.
Prophet1 mentions across 1 issues

Prophet is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between April 30, 2021 and April 30, 2021. The archive places it in contexts such as "The original Prophet solution to attaining that world by actively decreasing human populations"; ""probably the Prophets yelling at us for 50+ years", "I guess that’s as close to a steelman as I can get for Prophetry"". It most often appears alongside AI, AI research, Air.

Reference entry
Prophet
Mention count
1
Issue count
1
First seen
April 30, 2021
Last seen
April 30, 2021
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Your Book Review: The Wizard And The Prophet
April 30, 2021 · Original source
Some books really stick with me. Like, literally, stick with me: I’m one of those people with pretentious literary tattoos. So far, just two books have been meaningful enough for me to permanently etch their totem on my skin: the glyph of the underground postal service from The Crying of Lot 49, and the line "Everything Is Permitted," Jean-Paul Sartre’s misquoting of Dostoevsky’s take on atheism from The Brothers Karamazov. (I wasn’t kidding about pretentious!) People have all sorts of reasons for getting tattoos – mine are there for some of the standard superficial ones (looking cool and tough, obviously), but also to act as little daily mantras for how I want to live and think about the world. To this very short list of inked paragons, I’m thinking of adding a new one: a few stylized stalks of wheat in honor of Charles Mann’s The Wizard and the Prophet.
Inline links: misquoting
According to the instructions on the tin, The Wizard and the Prophet is meant to outline the origin of two opposing attitudes toward the relationship between humans and nature through their genesis in the work and thought of two men: William Vogt, the "Prophet" polemicist who founded modern-day environmentalism, and Norman Borlaug, the "Wizard" agronomist who spearheaded the Green Revolution. Roughly speaking, Wizards want continual growth in human numbers and quality of life, and to use science and technology to get there: think Gene Roddenbury’s wildest dreams, full of replicators and quantum flux-harnessing doodads that untether us from our eons-long project of survival on limited resources and allow us to expand limitlessly. "Prophets'' believe that we can’t keep growing our population or impact on the world without eventually destroying it, and ourselves along with it. Their ideal future is like one of those planets the Federation ships would Prime-Directive right over, where humankind scales back and lives in harmony with the land, taking just enough to sustain our (smaller) numbers and allowing the intricate web of human and non-human creatures to flourish.
Inline links: Green Revolution
Though Mann insists from the start that the book is not meant to advocate for or condemn either side, it was initially difficult for me to read it as anything but two-and-three-quarters cheers for Wizardry (more on the "initially" later). Part of this comes down to the challenge inherent in the genre: the book is structured first as a biography of Vogt and Borlaug ("Two Men"), then as an overview of how their Prophet and Wizard ideas play out in the modern-day battles over what to do about food, water, energy, and climate change ("Four Elements"). Starting the book with the personal and professional lives of these two men is a good way to show the very specific local contexts in which their ideas originated. Unfortunately, it’s also a good way to make Borlaug look like a saint, and Vogt like kind of an asshole.
prophetic perfect tense1 mentions across 1 issues

prophetic perfect tense is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between September 28, 2023 and September 28, 2023. The archive places it in contexts such as "the prophetic perfect tense , 'a literary technique used in the Bible that describes future events'". It most often appears alongside 2020 election, @eigenrobot, @jeremychrysler.

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Links For September 2023
September 28, 2023 · Original source
44: Little known grammatical tenses: the prophetic perfect tense, “a literary technique used in the Bible that describes future events that are so certain to happen that they are referred to in the past tense as if they had already happened.”
Inline links: prophetic perfect tense
Prophets1 mentions across 1 issues

Prophets is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between April 30, 2021 and April 30, 2021. The archive places it in contexts such as "it should belong to the Prophets". It most often appears alongside AI, AI research, Air.

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Prophets
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April 30, 2021
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April 30, 2021
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Your Book Review: The Wizard And The Prophet
April 30, 2021 · Original source
According to the instructions on the tin, The Wizard and the Prophet is meant to outline the origin of two opposing attitudes toward the relationship between humans and nature through their genesis in the work and thought of two men: William Vogt, the "Prophet" polemicist who founded modern-day environmentalism, and Norman Borlaug, the "Wizard" agronomist who spearheaded the Green Revolution. Roughly speaking, Wizards want continual growth in human numbers and quality of life, and to use science and technology to get there: think Gene Roddenbury’s wildest dreams, full of replicators and quantum flux-harnessing doodads that untether us from our eons-long project of survival on limited resources and allow us to expand limitlessly. "Prophets'' believe that we can’t keep growing our population or impact on the world without eventually destroying it, and ourselves along with it. Their ideal future is like one of those planets the Federation ships would Prime-Directive right over, where humankind scales back and lives in harmony with the land, taking just enough to sustain our (smaller) numbers and allowing the intricate web of human and non-human creatures to flourish.
Inline links: Green Revolution
Cult of personality aside, though, Vogt’s arguments may resonate with the utilitarians who believe that average utility matters more than total, so a world with fewer beings who lead happier lives is preferable to a world of unchecked growth that leads to worse outcomes for many individuals, human or dovekie. A version of this strain of thought is a perennial enough question to warrant its own FAQ item on the GiveWell blog. I think the revealed preference of most rationality/EA-aligned folks like me and probably many readers of this blog (as evidenced by the kinds of charitable causes we give to, like GiveWell) is more closely aligned with Borlaug and the Wizards: that it is important and possible to increase both average and total utility, both number of lives and quality of life. But even though it’s hard to imagine people today willingly deciding to stop reproducing above replacement or consuming goods for the sake of the mosquitos and dovekies (no matter how cute they are), it’s not unreasonable to think that as a normative matter, that world may in fact be a better one. The original Prophet solution to attaining that world by actively decreasing human populations may be less en vogue today what with eugenics and Malthusianism not exactly welcome topics in polite company, but it’s been replaced by other fears of overreaching capacity of one kind or another, be it oil, water, or greenhouse gases, and a desire to curb growth in these spheres and focus on conservation. Might there be some validity to the Prophets’ concerns that we can’t have it all (both average and total utility increases), and that we’re growing too quickly for our planet and its resources to keep up with us?
Inline links: warrant its own FAQ item on the GiveWell blog, cute they are
The second half of The Wizard and the Prophet explores four areas where humankind faces major dilemmas and needs some form of action (whether Wizardry or Prophetry) in order to survive. Mann names each chapter after one of the four elements: Earth (food), Water (self-explanatory), Fire (energy), and Air (climate change). Again, while Mann gives ample airtime to both worldviews and their proposed solutions, Wizards come out looking pretty good. Each chapter sees the Wizards demonstrate over and over that carrying capacity in these spheres is not fixed and can be altered by science and technology – earth through hacking photosynthesis to produce more abundant crop yields with the same soil and water inputs, water through desalination plants and massive public works projects to move water from more to less abundant environments, energy through better use of legacy fuel sources and finding new ones, and climate change through carbon capture. The Prophets, meanwhile, decry the dangers of both growth and Wizardry (insofar as it enables growth) and argue for social change that seems, at best, limited in impact, and at worst, impossible and ineffective. But the question remains: are we creating a better world by increasing global capacity with our Wizardly tricks, or are we overreaching and dragging down the quality of life around us?
propofol1 mentions across 1 issues

propofol is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between November 14, 2023 and November 14, 2023. The archive places it in contexts such as "The anaesthetic propofol, used in about 88% of these patients". It most often appears alongside ketamine, ketamine, MADRS.

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propofol
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November 14, 2023
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Does Anaesthesia Prove Ketamine Placebo?
November 14, 2023 · Original source
Second, anaesthetics themselves are antidepressants! (thanks to St_Rev for mentioning this). The anaesthetic propofol, used in about 88% of these patients, “may trigger rapid, durable antidepressant effects”, with a purported effect size well above that of SSRIs (these trials are very small, but so was the ketamine trial).
Inline links: “may trigger rapid, durable antidepressant effects”, well above that of SSRIs
So maybe they were giving all these patients a strong antidepressant, plus half of them a second strong antidepressant. Several studies have shown that two antidepressants don’t always work much better than one, so maybe the ketamine didn’t add much to the propofol.
So I’m not sure we should expect to see much of the effect of ketamine through the quadruple smokescreens of placebo effect, antidepressant effect of propofol, patient unconsciousness, and the MADRS-confounding effect of being in the hospital. I’ll be honest, it still surprises me to see literally zero effect (outside the remission/response statistics). I think this rules ketamine out as a miracle drug that cures everybody of everything. But I don’t think it completely rules out that it’s an okay antidepressant with an effect size of 0.7 or something, like all the other studies say.
Proposition 11 mentions across 1 issues

Proposition 1 is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between March 04, 2024 and March 04, 2024. The archive places it in contexts such as "interesting thoughts on Proposition 1 (mental health funding)". It most often appears alongside Asimov Press, Astralcodexten Com, Berkeley.

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Proposition 1
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March 04, 2024
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Open Thread 318
March 04, 2024 · Original source
3: I won’t have a voting guide up in time for the California primary on Tuesday, but Jessica Ocean of the PsychCrisis blog has interesting thoughts on Proposition 1 (mental health funding).
Inline links: has interesting thoughts on Proposition 1
Proposition 221 mentions across 1 issues

Proposition 22 is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between November 04, 2022 and November 04, 2022. The archive places it in contexts such as "Proposition 22 (make it hard for Uber and Lyft to do gig employment)". It most often appears alongside ABSTAIN, Alex Padilla, American Nurses Association.

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Proposition 22
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November 04, 2022
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My California Ballot 2022
November 04, 2022 · Original source
Until now, Proposition 22 (make it hard for Uber and Lyft to do gig employment) was the most expensive proposition in California history. But it looks like Proposition 27 is going to beat 22 for this heavily-contested title. It lets out-of-state companies provide online sports betting in California if they bribe some Indian tribe that has gambling rights to say the Indian tribe supports them.
Inline links: Proposition 27 is going to beat 22
Proposition 271 mentions across 1 issues

Proposition 27 is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between November 04, 2022 and November 04, 2022. The archive places it in contexts such as "Proposition 27 is going to beat 22 for this heavily-contested title". It most often appears alongside ABSTAIN, Alex Padilla, American Nurses Association.

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Proposition 27
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November 04, 2022
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My California Ballot 2022
November 04, 2022 · Original source
Proposition 27: Legalize Online Sports Betting, Tax It, And Give A Tiny Fraction Of The Money To Various Sympathetic Causes
Until now, Proposition 22 (make it hard for Uber and Lyft to do gig employment) was the most expensive proposition in California history. But it looks like Proposition 27 is going to beat 22 for this heavily-contested title. It lets out-of-state companies provide online sports betting in California if they bribe some Indian tribe that has gambling rights to say the Indian tribe supports them.
Inline links: Proposition 27 is going to beat 22
Proposition 281 mentions across 1 issues

Proposition 28 is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between November 04, 2022 and November 04, 2022. The archive places it in contexts such as "Proposition 28: Provide Additional Funding For Arts And Music In Public Schools". It most often appears alongside ABSTAIN, Alex Padilla, American Nurses Association.

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Proposition 28
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November 04, 2022
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November 04, 2022
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My California Ballot 2022
November 04, 2022 · Original source
Proposition 28: Provide Additional Funding For Arts And Music In Public Schools Without Raising Taxes Somehow
Proposition 471 mentions across 1 issues

Proposition 47 is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between June 23, 2022 and June 23, 2022. The archive places it in contexts such as "Proposition 47 There are two good big studies on the effects of Prop 47". It most often appears alongside 1978, 2016 essay, A Resounding Success Or Disastrous Failure: Re-examining The Interpretation Of Evidence On The Portuguese Decriminalisation Of Illicit Drugs.

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Proposition 47
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June 23, 2022
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Book Review: San Fransicko
June 23, 2022 · Original source
Source: Ed West, do note that this example is from the UK How suspicious should we be of each type of story? There will always be an extreme right tail of overly harsh sentences, and an extreme left tail of overly lenient ones. Were the 2000s really as draconian as they felt? Is the modern era really as pathetic? Or is it all just a function of who you read and what agenda they’re pushing? Shellenberger: During California governor Jerry Brown’s time in office, voters passed several reforms aimed at reducing the size of the prison population. In 2012, voters passed a change to the Three Strikes law so that the third strike imposes a life sentence only if the new felony was serious or violent. In addition to lowering punishments for drug possession, Proposition 47, which voters passed in 2014, redefined shoplifting, forgery, petty theft, and receiving stolen property as misdemeanors when the value in question does not exceed $950. In 2016, voters approved a proposition that shortened the time it took for some nonviolent offenders to be eligible for parole and which released nonviolent offenders into drug treatment and rehabilitation. Property crimes rose in San Francisco starting in 2012. Larceny, which is shoplifting and other petty theft, rose 50 percent, from roughly 3,000 incidents per 100,000 people in 2011 to about 4,500 in 2019. Property crimes as a whole, which include larceny, motor vehicle theft, and burglary, rose from 4,000 incidents per 100,000 people in 2011 to 5,500 in 2019. One study suggests that Proposition 47 increased the rate of auto theft 17 percent and the rate of larceny (non-auto property) theft 9 percent, but discerning between causation and correlation may not be possible. Upon taking office in January 2020, [famously soft-on-crime San Francisco district attorney Chesa] Boudin followed through on his campaign promises. Instead of prosecuting and incarcerating people for breaking car windows to steal money and other items from inside, Boudin proposed creating a $1.5 million fund to reimburse car owners. But there were over 25,000 car break-ins reported in 2019. If every break-in cost just $250 in repairs, the fund would need four times that amount. And what would prevent people from falsely claiming to have been robbed in order to get city money? […] Boudin opposed efforts by the mayor and the city attorney to prevent drug dealers who had already been arrested from entering the Tenderloin. “Until the city is serious about treating addiction and the root causes of drug use and selling,” said Boudin in a statement, “these recycled, punishment-focused approaches are unlikely to succeed at doing anything more than making headlines.” Home burglaries rose in early 2021 in San Francisco. Homeowners started posting on Twitter videos from their security cameras of people breaking into homes and garages. “When I first moved here we had a car break-in problem,” said Michael Solana, a writer who works for a venture capital fund. “Now we have a home invasion problem. These things are wearing on people.” Boudin attributed the rise of burglaries in San Francisco to the decline of tourism and “people in desperate economic circumstances.” Progressive supervisor Hillary Ronen agreed. “We know that [economic insecurity and inequality] is one of the root causes of property crimes specifically,” she said. But Tom Wolf and others argued that the robberies were, like the shoplifting, done by people seeking money to buy drugs and feed their addictions. “The drugstores have been shoplifted to death and that’s all because of drug use,” said Tom. “I know. I used to do the same thing when I was out there. That’s what you do. You ‘boost.’ And then you go and you sell your stuff down at UN Plaza,” an open-air drug scene. In a May 2021 city supervisors’ meeting, a representative from CVS called San Francisco “the epicenter of organized retail crime in the country” and claimed that 85 percent of the shoplifting is committed by organized theft rings. Police broke up one such ring in October 2020 and recovered $8 million of stolen merchandise. The problem goes beyond property crime. Boudin declined to prosecute two men who went on to kill people. One man had been repeatedly arrested for stealing cars, despite having just been released from prison earlier in the year, and appeared to be abusing meth. On New Year’s Eve, 2020, the man killed two people while driving intoxicated. Police found inside of his car a semiautomatic handgun and twenty-three grams of methamphetamine. On February 4, another intoxicated driver killed a pedestrian in a stolen car. The San Francisco police had arrested him in October 2020 for possessing a stolen car, a tool for stealing cars, and what appeared to be meth. Boudin chose not to pursue charges. In December, the California Highway Patrol arrested the man again for driving a stolen vehicle under the influence. Again he was not prosecuted. The accident victim, an immigrant from Kenya, and his wife had moved to San Francisco two weeks before the fatal crash. “I blame the DA,” said the widow of the victim. The suspect, she said, “was someone who was out in the public who shouldn’t have been in the public. It was completely avoidable.” Tom said he could feel the difference on the streets. “Drug dealing is unabated and it’s not one guy, it’s fifty guys dealing fentanyl and meth,” he said. “And it’s going unabated because the district attorney says, ‘These are the nonviolent, quality-of-life crimes,’ and ‘I’m not going to prosecute them.’” [..] District Attorney Boudin was offering weaker sentences than even defense attorneys were requesting, according to Vicki Westbrook of San Francisco. “There’s a defense attorney who said, ‘It used to be that I would argue for this deal in court with the DA but now I don’t say anything because the DA is going to offer me a deal better than what I would have suggested. Somebody shot up the street with an automatic weapon. The first offer was six months in jail or time served plus two years of probation or something. And then [the DA] said, “How about thirty days in jail?”’” Vicki laughed. “You really can do anything in San Francisco,” she said. “If you do get arrested, chances are you’re going to be out of jail in less than thirty days for damn near everything except maybe killing somebody and maybe even then, too. It’s hard to say at this point.” Taking each of these points individually: Proposition 47 There are two good big studies on the effects of Prop 47, one by Public Policy Institute and one by some UCI criminologists. The PPI study finds that the proposition increased theft and car break-ins by about 10%. The UCI study finds the same, but notes that under different assumptions the effects wouldn’t quite obtain statistical significance. This seems a bit too much like post hoc trying to get rid of an inconvenient effect, plus an effect on the border of statistical significance is different from positively finding no effect. I think a reasonable interpretation is that theft and car break-ins rose about 10% because of the proposition, just as Shellenberger says. Some pro-47 sites note that most states have some limit on how much you to have to shoplift before it’s a felony, and Prop 47 brought California closer to the national average, rather than turning it into an outlier. Chesa Boudin Chesa Boudin took office two months before the COVID pandemic began. Any attempt to separate the effect of Chesa Boudin from the effect of the pandemic is doomed. Shoplifting definitely plummeted when Boudin took office, but that’s because all the stores were closed. Murders definitely rose a little after Boudin took office, but that’s because that was also when the Black Lives Matter protests happened, which demoralized police and led to a so-far-permanent spike in murders nationwide. Percent of criminals caught definitely fell when Boudin took office, but that’s because various aspects of the justice system were closed for COVID (I will grudgingly entertain speculation that a further decrease in arrest rates from 2020 to 2021 may have been a genuine Boudin effect). In the absence of any real way to judge his performance, I think San Fransicko’s points about Boudin are plausible, though speculative. Shoplifting This one is terrible. There’s a surprisingly spirited debate here (some of you may have already read Applied Divinity Studies’ article). The debate is: everyone on the ground in San Francisco - store owners, security guards, customers, random citizens - say that shoplifting has increased massively over the past decade. But statistics mostly say it hasn’t. Source here. This is shoplifting crimes per 100,000 people. Kern County is a deep red county in California (including Bakersfield) that is known for being tough on crime. Against this, seriously, everyone says that shoplifting has obviously increased. I had a patient who worked in shoplifting prevention, he told me - his psychiatrist! Who he had no reason to lie to! - that he was constantly stressed dealing with the shoplifting surge devastating the stores he covered. Here’s the San Francisco subreddit’s response to someone posting the data showing shoplifting hasn’t risen - it’s just a lot of people laughing hysterically. What’s going on? I was able to find a different set of statistics that does seem to show a longer-term increase in shoplifting (source): The very big spike at the end might be a change in reporting by one or two stores - you can find the argument here. But it does look like shoplifting went from about 125 incidents/month in the early 2010s to more like 250/month just before the pandemic. Why is this graph so different from the other one? It looks like the top one came from the Department of Justice, and the bottom one came from SFPD. I’m not sure why these report differently. When you multiply out by 800K people in SF, by 12 months/year, and 30ish days/month, the first graph corresponds to 4 shoplifting incidents per day, and the second to 6. As LouB’s analysis here points out, that seems suspiciously low for a city of 800,000 people where stores are constantly closing because of shoplifting. Maybe off by a factor of a few hundred from what we’d expect. LouB writes: The SFPD report only references shoplifting offenses that required SFPD officers to prepare an incident report. That means either the shoplifter fought security, committed additional crimes, or stole more than $950 worth of items. It’s not that SFPD’s report is erroneous, it’s just not a representative statistic. In a parallel statistic, SFPD only completes incident reports for traffic accidents when there is an injury. Therefore, thousands of noninjury accidents are handled civilly without SFPD reports the same way thousands of shoplifting offenses are handled without reports. An insurance company would not determine premium rates based solely on SFPD incident reports, nor should readers interpret SFPD shoplifting reports as anywhere near the total picture of the shoplifting epidemic in San Francisco. (this would also explain why one or two stores changing their reporting policy can produce a spike equal to everyone else in San Francisco combined) But comparing incident reports from 2010 to incident reports from 2020 should still be apples-to-apples, unless the likelihood of reporting any given incident changed in the meantime. Did it? This news article quotes a San Franciscan who says that when they try to report shoplifting incidents, the cops tell them not to because “it doesn’t make a difference”. If cops say that now more often than they used to, it would make all these statistics meaningless. (Applied Divinity Studies claims to have an argument that shows this can’t be true. It goes something like: if San Francisco was a better place to shoplift than its neighbors - eg Oakland - then shoplifters would leave Oakland to go to San Francisco, and we would see Oakland shoplifting rates falling. Oakland shoplifting rates are falling, but no more so than the rest of the state, so there can’t be increased tolerance for shoplifting in San Francisco. I find this dubious for many reasons. First of all, many of the same reasons shoplifting is up in San Francisco - like Prop 47 or soft-on-crime progressive policies - also apply to Oakland. Second, given that shoplifting fell massively everywhere because of the pandemic, it feels dubious to try to compare different cities; maybe one city had stricter pandemic lockdowns than others. Third, do criminals really shop around for friendly jurisdictions? If so, why are so many crimes like car break-ins, concentrated in “the bad part of town”? Why wouldn’t criminals leave the bad part of town for under-exploited areas with richer residents and less competition? Maybe criminals in fact aren’t very strategic or mobile? Maybe they don’t want to stand in the BART station and then take a half-hour train ride holding a bag of stolen goods?) Maybe a better argument against this being true is how stable the shoplifting rates have been over time. Wouldn’t it be weird if (let’s say) a tripling of the real shoplifting rates was matched by a third-ing of the reporting rates (rather than a halving or a quartering or whatever)? On the other hand, here’s Shellenberger with some helpful data: Some of this is probably because of Proposition 47, which made some forms of shoplifting punishable with citation rather than arrest (but wouldn’t that be a clear discontinuity rather than a gradual trend?) But overall it sure seems like shoplifting is being taken less seriously, which might encourage people to report less. Another statistic I see is that only 2.3% of shoplifting cases result in an arrest; I don’t know how this is different from the graph above with numbers in the 30s; maybe it involves different levels of what makes something a “case”. I accept that the data don’t consistently show a spike in shoplifting. But what’s the alternative? My patient who works in loss prevention in SF stores is lying to me? The nice elderly Chinese man who sold me my last pair of glasses and chatted to me about the rampant shoplifting in his mall was lying? The San Francisco police are lying? Walgreens pretends to be concerned about shoplifting as part of a dastardly plot to close a bunch of stores for no reason? Target and CVS pretend to care about shoplifting as part of a plot to restrict their stores’ opening hours for no reason? Every big store near me has suddenly gotten a security guard at the front as part of some corporate-sponsored jobs program? Maybe the conservative narrative that soft-on-crime San Francisco must be experiencing rising crime rates took on a life of its own. Maybe it infiltrated not just the usual suspects like the SF police unions, but even such supposedly-liberal bastions as the New York Times. Maybe lots of big corporations took advantage of the fake narrative to make unpopular business decisions they were planning on making anyway. And maybe ordinary San Franciscans, confronted with everyone telling them they were in a shoplifting epidemic, started paying more attention to security guards and petty criminals who had always been there, a sort of mass hallucination that gripped everyone in the city. I can’t rule this out. Americans thought crime was rising all throughout the early 2000s, when it was in fact way down. Or maybe some statistics that we already know are off by several orders of magnitude got off by an additional factor of two or so. I think this one is more likely, but I’m genuinely not sure. Other Crime From the Economist: The Center on Juvenile And Criminal Justice puts it even more starkly, arguing that “San Francisco’s ‘Crime Wave’ Is Just One Crime”: This are potentially susceptible to the same reporting bias as shoplifting. So what about homicide? Homicide is practically always reported and investigated, making it a gold standard in crime measurement. (source) Looks pretty good until 2019. I don’t expect to gain useful information post-2020; the pandemic and the post-George-Floyd murder surge will make it impossible to evaluate for local variation. What about compared to other places? For some reason this top 20 table fails to list Washington DC, which should be just before Atlanta. SF doesn’t make the top 20, although its neighbor Oakland does. Probably most murder variation in US cities is explained by percent African-American and maybe percent Borderer; with relatively few people in these groups SF was never in the running. I’m not sure if some abstracted version of the city with all demographic factors adjusted away would have an unusually high murder rate, but at that point it would be pretty distant from any interesting real-world question. You can see the leaderboard for other types of crime here; San Francisco is often in the top ten, but never the top three. As far as I can tell, San Francisco has seen a big spike in car breakins over the past few years, with no clear trend for other property crime, violent crime, or homicides. It’s not an outlier among American cities in any kind of crime. Conclusion of this section: San Fransicko’s specific claims are basically correct, but suggest a medium-term rise in SF crime which is mostly contradicted by the data. These show stable-to-decreasing murder, stable-to-decreasing violent and property crimes other than car break-ins, and large rises in car break-ins only. The data also show stable-to-decreasing shoplifting, but I’m not sure how much to trust them vs. common sense. Honestly, I’m pretty confused here and not sure what to think. Claim 7: Jim Jones (Of Kool-Aid Cult Fame) Used To Be The Chairman Of SF’s Housing Authority Okay, this isn’t really a statistical claim that I can research different perspectives on. Still, it’s so wacky that I couldn’t resist mentioning it in this review. Jim Jones, famous for killing everyone in his Guyana-based Jonestown cult with poisoned Kool-Aid, used to be the SF government’s top guy on homelessness. Shellenberger writes: Jones married and moved first to Northern California and then to San Francisco with his wife to start a church. He called it the People’s Temple. Jones believed he was the leader of a socialist revolution. He warned of nuclear war and claimed black people would be put in concentration camps. He became a hugely charismatic preacher among African Americans, the disaffiliated poor, and young transplants to the city looking for community. Scenes from the era show a remarkably large and diverse congregation smiling and singing. The People’s Temple grew and provided services. Jones cultivated two progressive San Francisco politicians, George Moscone and Willie Brown, and mobilized people to volunteer for their campaigns […] His son and a San Francisco historian believe he stole the mayoral election for Moscone in 1975. Historian David Talbot, founder of the progressive website Salon, points to evidence that Jones committed sufficient voter fraud to account for Moscone’s narrow 4,443-vote margin of victory. “We loaded up all thirteen of our buses with maybe seventy people on each bus, and we had those buses rolling nonstop up and down the coast into San Francisco the day before the election,” said Jones Jr. “Could we have been the force that tipped the election to Moscone? Absolutely! Slam dunk. He only won by four thousand votes.” When federal investigators looked into fraud claims three years later, they discovered that all of the records were missing from the city of San Francisco’s registrar of voters. Jones also boasted of providing Moscone with black women from his congregation for sex. One time Moscone, drunk and “accompanied by a young black woman whom the politician had kindly agreed to drive home,” crashed into another car. Another time, Moscone and Willie Brown “were with a black woman in an alley at two in the morning at some restaurant in North Beach,” said a local bar owner. State legislator “John Burton was part of that gang too. They were all using marijuana and cocaine.” Said Jones Jr., Moscone would “always be there at temple parties with a cocktail in his hand and doing some ass grabbing.” A Temple member overheard Jones speaking to Moscone the day after one of those parties saying, “I want to let you know that the young lady you went off with is underage,” adding, “Now don’t worry, Mayor, we’ll take care of you—because we know that you’ll take care of us.” Afterward, Moscone made Jones the chairman of the powerful San Francisco Housing Commission. Jones cultivated progressives with money and favors. He made large donations to the ACLU, the NAACP, and United Farm Workers. Jones and Moscone met privately with vice presidential candidate Walter Mondale on a campaign plane a few days before the 1976 presidential election, and Mondale praised People’s Temple shortly afterward. Jones met with First Lady Rosalynn Carter several times. Governor Jerry Brown praised Jones. Glide Memorial Church’s Rev. Cecil Williams loved Jones. There is a photo from 1977 of a smiling Williams awarding Jones the church’s “Martin Luther King, Jr. Award.” Jones used his perch as chairman of the Housing Commission to fight for housing for the poor. He tried to use eminent domain to acquire the International Hotel, a single resident occupancy hotel. After a court sided with the hotel’s owner, Jones mobilized seven thousand protesters to picket it. By mid-January 1977, the situation had become heated. There were rumors that protesters inside the building were armed with guns and Molotov cocktails. Jones lost the legal battle in 1977, and the tenants were evicted. But the drama was a publicity victory for Jones, which burnished his image as a white savior. A conservative member of the Board of Supervisors who was defeated in the mayoral election by Moscone accused the new mayor, the San Francisco Chronicle, and the rest of the city establishment of being blind to Jones’s extremism. “There’s no radical plot in San Francisco,” insisted Moscone, in response. “There’s no one I’ve appointed to any city position whom I regard as radical or extremist.” Willie Brown, a powerful state legislator from 1964 to 1995 before becoming mayor in 1996, “seemed oblivious to Jones’ hucksterism and demagoguery,” notes a historian. Brown was master of ceremonies at a dinner for Jones in the fall of 1976 attended by an adulatory crowd of the rich and powerful, including Governor Jerry Brown. “Let me present to you a combination of Martin King, Angela Davis, Albert Einstein . . . Chairman Mao,” he said, to loud applause. And yet Jones was contemptuous of Brown even as Brown did Jones more and more favors. Jones mocked Brown for his designer suits, sports cars, and women. Once, while Brown was addressing the congregation and Jones was seated onstage behind him, Jones flipped his middle finger up to mock him. San Francisco’s establishment stood by Jones even after a California magazine, New West, owned by Rupert Murdoch, published an exposé of Jones’s beatings of Temple members and financial abuses in August 1977. The article was written by a San Francisco Chronicle reporter and was meant for the Chronicle to publish. But the newspaper killed the story because it didn’t want to alienate Jones, whom it viewed as central to its plans to expand the Chronicle’s circulation in the heavily African American Fillmore District. Jones also managed to avoid investigation and prosecution in part by getting the district attorney to hire as deputy district attorney Jones’s longtime attorney and confidant. Progressives defended Jones against the New West article. At a rally in the summer of 1977, Willie Brown said, “When somebody like Jim Jones comes on the scene, that absolutely scares the hell out of most everybody occupying positions of power in the system.” Angela Davis sent a radio message broadcast over the cult’s compound, Jonestown, in Guyana. “I know you’re in a very difficult situation right now,” she said, “and there is a very profound conspiracy designed to destroy the contributions which you have made to the struggle.” After visiting Jonestown, the attorney to the Black Panthers said, “I have seen paradise.” Harvey Milk, too, was tarnished by his association with Jones. In the fall of 1977, Milk wrote to President Carter’s secretary of health, education, and welfare requesting that Social Security checks be sent to elderly Temple members in Guyana. “People’s Temple,” wrote Milk, has “established a beautiful retirement community in Guyana.” In truth, the cult was disintegrating. Jones separated families and lovers, pitted relatives against each other, and forced neighbors to inform on each other. Jones sent people who violated the rules to solitary confinement in “the Box,” an underground cubicle where people were held as prisoners for days on end. Others were drugged. Progressives who had spent thirty years fighting to close prisons and mental hospitals found themselves praising a man who had reproduced their worst practices. In November 1978 a Bay Area congressman flew to Guyana to investigate human rights violations at Jonestown with NBC News. Jones gave the delegation a formal reception at Jonestown. A Temple member surreptitiously passed a note to one of the delegation members, saying he and another member wanted to escape. They fled the next day after a Temple member tried to stab the congressman. Jones didn’t prevent them from leaving but then sent gunmen to fire machine guns at the delegation at the airport, killing the congressman and four others. A few hours later, 907 inhabitants of Jonestown drank Flavor Aid laced with cyanide and died. Two-thirds of the victims were African American and one-third were children. Jones had told them that if they didn’t drink it they would be killed by invading soldiers from a shadowy global military conspiracy intent on imposing fascism and torturing children. As people started crying in grief, Jones scolded them. “Stop these hysterics,” he said. “This is not the way for people who are socialists or communists to die.” Jones’s wife protested the murder of children and had to be forcibly restrained. “We didn’t commit suicide,” said Jones in a tape recording, “we committed an act of revolutionary suicide protesting the conditions of an inhumane world.” Few were as stained by Jonestown as Willie Brown and George Moscone. “Even as the bloated bodies of the dead were removed from the jungle and the wounded were airlifted by the U.S. Air Force to hospitals in the United States,” wrote a historian, “Brown said he had ‘no regrets’ over his association with Jones.” They repeatedly disavowed responsibility. Said Moscone, “it’s clear that if there was a sinister plan, then we were taken in. But I’m not taking any responsibility. It’s not mine to shoulder.” This is Shellenberger at his best: telling us crazy stories from the recesses of San Francisco history, maybe kind of spinning the narration in a way that makes all progressives seem guilty by association, but with the tale itself so gripping that it’s hard to be mad. And Jones wasn’t alone. This was the golden age of San Francisco cults, when (Shellenberger tells us) “more than half of all high school students in the San Francisco Bay Area reported at least one recruiting attempt by a cult member, and 40 percent reported at least three contacts.” This chapter of SF history came to an end in 1978, when Dan White, who had just resigned from San Francisco’s Board Of Supervisors (ie City Council) entered City Hall through a window and assassinated Mayor Moscone and fellow Supervisor Harvey Milk, then successfully got charges reduced to manslaughter through a legal manuever that has gone down in history as “the Twinkie Defense” (realistically the defense was that he was depressed, but reporters seized on a comment that implied it was because he ate too many Twinkies). Everything about 1970s San Francisco was like this. With the Mayor and his right-hand-man both dead, San Francisco leadership ended up in the hands of previously second-tier politician Dianne Feinstein. Feinstein was what passed for a moderate in 1970s SF (which meant she had been targeted for assassination by various left-wing groups - she survived when a bomb left on her windowsill failed to explode). In Shellenberger’s telling, she managed to clean up some of the mess and restore a semblance of normalcy. San Francisco never forgave her. Moscone - voting fraud committer, underage sex enjoyer, and Jim Jones’ bff - is beloved as a martyr in today’s SF, but (the book points out) Feinstein is so loathed that in 2021 the Board of Education voted to rename Dianne Feinstein Elementary School. The Moscone Center is 2 million square feet and can fit about 10,000 people. Not to be confused with the Moscone Recreation Center, Moscone Station, or Moscone Elementary School. Meanwhile, all Dianne Feinstein got was one lousy elementary school and the Tithonus package of eternal life without eternal youth. Claim 8: The Intolerant Left Shuts Down Debate On These Issues Another one that’s probably hard to do a randomized controlled trial on. You could probably predict that this one was coming - it’s a necessary narrative beat in this genre of book. I think this beat is good. My impression is that people who aren’t themselves public figures disagreeing with left-wing ideas still don’t understand how scary it is and how much hate you get. Maybe now that 2/3s of every political essay written over the past five years is about this topic, people will finally get it through their thick skulls that it exists and is bad. I would also note that “traumatizing the sorts of people who write popular books about politics, in a such a way that they feel compelled as a sort of self-therapy to write page after page telling readers how angry they should be at you and your whole coalition” isn’t great political praxis. I would like people to figure this out and stop doing it. Anyway, Shellenberger is doing his part in this effort: In 2001, the San Francisco Coalition on Homelessness wheat-pasted posters of a fake front-page San Francisco Chronicle across town. Just beneath the masthead a large headline read “Fuck the Homeless!” right above a picture of San Francisco mayor Willie Brown laughing. Below his photo was the headline “Save the Tourists.” Progressives level the same charges at people thirty years later. “Because of some of the stuff I say,” said a community activist in Seattle’s historically black Capitol Hill neighborhood, “people say, ‘Oh, she’s not for them.’ But I have a heart for homeless and mentally ill. Most of my family works with the mentally ill.” Noted a Chronicle journalist in 2017, “Inevitably, homeless advocates and others will say, ‘You’re not compassionate,’” in response to stories about homeless encampments. “They called me a racist,” said Tom. “They accused me, a guy who used to be homeless, of demonizing the homeless, because I’m asking for accountability.” I found myself similarly accused. In 2019, after I published an article for Forbes about the homeless crisis, a progressive homeless activist accused me on Twitter of having written my article to “make money off of a fear tactic” of “fueling hatred [and] even increasing violence against homeless people.” After I asked the former San Francisco supervisor for the Tenderloin neighborhood, former mayoral candidate Jane Kim, how such a progressive city ended up with so much suffering, she said, “My concern, Michael, just to be very honest, is that when that kind of messaging goes out, violence against people who are unhoused goes up.” […] I soon discovered in my research that I was hardly the first person that progressive elected officials and homelessness advocates had accused of fomenting violence against unhoused people. Many others had been criticized for far worse over the years, including San Francisco’s highest elected officials. “The criticism [by progressive homelessness advocates] was heavy, political and personal,” wrote former mayor Willie Brown in his 2008 memoir. “People accused me of abandoning the problem when I was working daily to try and get a solution going. It was brutal. . . . I had become demonized, and my own efforts belittled.” It is notable that the result of such personal attacks is to frighten off people seeking to change, and perhaps improve, the situation. “The problem” of homelessness, concluded Mayor Brown within nine months of entering office, “may not be solvable.” And [Quoting Chris Rufo]. “The chief of psychiatry in a public hospital system in one of the largest California cities told me, ‘I know for a fact, and all of my colleagues know, that what we actually need to deal with the problem in the biggest cities in California is long-term residential secure psychiatric care. But I can’t say that publicly because I would be disemboweled by the activist left. My job would be in jeopardy. My reputation would be in jeopardy. My whole life would get turned upside down for even broaching the subject of expanding secure mental health facilities and compulsory mental health treatment.’ And I said, ‘So what’s the solution?’ and this person said, ‘We muddle through.’” And: In San Francisco, radical left activists protested [African-American] Mayor London Breed in front of her home. Breed said the protesters were “all white people. But that didn’t bother me as much as the taunting of me coming outside with firework torches in their hands looking like what used to happen when the KKK would show up to black people’s houses to burn their houses down.” While I was reading the book, I came across this tweet, which suggests that being unimpressed with SF’s lefty homeless activist scene is not limited to Michael Shellenberger: Claim 9: European Cities Like Amsterdam Successfully Solved Their Own Drug And Homelessness Problems By Doing The Opposite Of SF Shellenberger bases his plan to solve these problems on ideas that he says were pioneered in Amsterdam and spread to other European cities. In the 1980s, Amsterdam had the kinds of problems San Francisco deals with now: open-air drug markets, overdose deaths, homelessness, and crime. But in the 90s, they admitted they had a problem and took decisive action: What’s the secret?” I asked him. “Amsterdam has decriminalized marijuana and many other drugs but I haven’t seen any homeless. What is San Francisco doing wrong?” Rene said that in the 1980s, the Zeedijk neighborhood in Amsterdam was a lot like the Tenderloin [the worst part of San Francisco] today. There was open-air drug use, particularly of heroin, and needles strewn about, as well as crime. People started to flee the neighborhood, worsening its slum conditions. Homeless people squatted in abandoned buildings. “We had ghettos where it was not safe to go,” said Rene, who started working in the neighborhood as a nurse in 1985. It was considered a “no go” zone. “We had a lot of people from abroad who came to Amsterdam because our heroin was so good. But our heroin was so good that they died from it.” At first the city tried a “helping approach” exclusively, offering addicts clean needles, methadone, and other forms of help without any law enforcement, but it didn’t work. “In the eighties we just wanted to help people,” said Rene. “We started with methadone programs and medical treatment. We did a lot of work without much of a carrot and a stick. It was really a disappointment. They just used the methadone to stay addicted. They dealt drugs and committed other crimes. They lied and cheated about it. We were just supporting a different kind of market. We had to learn the hard way [...] The Amsterdam City Council asked the Amsterdam Municipal Health Service to develop a strategy to deal with “unmotivated drug users”...The police broke up the open-air drug scene and health workers were on hand to offer methadone, treatment, and shelter. The police broke up gatherings of more than four or five users, but did not treat personal and private use as a crime. Officers ticketed violators, and if users did not pay their fines, which was frequent, the courts ordered arrests, and sentenced individuals to follow a treatment plan or face incarceration. “For every individual homeless person, we make a plan,” said Rene. “We made tens of thousands of those plans.” Plans are overseen by a caseworker and a team that may include a psychiatrist, shelter provider, service provider, judge, employer, parole officer, and police officer. “You need people in the police and health department working together,” he said. What Amsterdam did was the same as other major European cities. Lisbon, Frankfurt, Vienna, and Zurich all dealt with their open-air drug markets, using a combination of law enforcement and social services. Crucially, Amsterdam and other European cities prevented services from being concentrated in a single neighborhood, since their concentration often enables an open-air drug scene to thrive [...] The efforts worked. “We had several thousand people who were addicted to heroin in the eighties and nineties,” said Rene. “Many died. Today we have four or five hundred people addicted to methadone. And we have about 120 in Amsterdam who we supply heroin to on a medical basis because methadone doesn’t work for them. They have to use heroin.” The Amsterdam strategy goes something like: Break up open-air drug markets and anywhere that more than 4-5 drug users are congregating. Yes, people can just use their drugs in private, but this is legitimately better. Open-air markets normalize drugs with their blatantness, and make it hard to quit for the same reason it’s hard to diet if your partner leaves boxes of donuts out in the house every day.
Inline links: Ed West, Public Policy Institute, UCI criminologists, Applied Divinity Studies’ article, https://substackcdn.com/image/fetch/$s_!aTNC!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2Fa27aeb21-ed87-4e67-b82c-b3ceecee7082_500x238.png, here, Here’s the San Francisco subreddit’s response, https://substackcdn.com/image/fetch/$s_!_NL6!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2Fcf7dc478-45d3-487d-8c29-8bc7cdf182dd_2400x1500.png, LouB’s analysis here, This news article, only 2.3% of shoplifting cases result in an arrest, New York Times, the Economist, https://substackcdn.com/image/fetch/$s_!58I3!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2Fc63dc7bc-1f8e-49fd-9c68-61c85278d69e_608x662.png, San Francisco’s ‘Crime Wave’ Is Just One Crime, https://substackcdn.com/image/fetch/$s_!h17s!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F956c0917-2a9b-4ff7-a08e-6aee5030583a_590x376.png, https://substackcdn.com/image/fetch/$s_!TkFS!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F5c5faa01-ac22-48a2-96fe-47efb6f52514_616x334.png, source, https://substackcdn.com/image/fetch/$s_!Bg2w!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F18e49c63-16ba-4878-96e6-aec12d7c5953_481x667.png, percent African-American, percent Borderer, here, the Twinkie Defense, https://substackcdn.com/image/fetch/$s_!8wK3!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F683b9754-f663-47ad-88f5-aa99bc208ec8_1401x622.jpeg, https://twitter.com/weheartprez/status/1526983899309432832
The very big spike at the end might be a change in reporting by one or two stores - you can find the argument here. But it does look like shoplifting went from about 125 incidents/month in the early 2010s to more like 250/month just before the pandemic. Why is this graph so different from the other one? It looks like the top one came from the Department of Justice, and the bottom one came from SFPD. I’m not sure why these report differently. When you multiply out by 800K people in SF, by 12 months/year, and 30ish days/month, the first graph corresponds to 4 shoplifting incidents per day, and the second to 6. As LouB’s analysis here points out, that seems suspiciously low for a city of 800,000 people where stores are constantly closing because of shoplifting. Maybe off by a factor of a few hundred from what we’d expect. LouB writes: The SFPD report only references shoplifting offenses that required SFPD officers to prepare an incident report. That means either the shoplifter fought security, committed additional crimes, or stole more than $950 worth of items. It’s not that SFPD’s report is erroneous, it’s just not a representative statistic. In a parallel statistic, SFPD only completes incident reports for traffic accidents when there is an injury. Therefore, thousands of noninjury accidents are handled civilly without SFPD reports the same way thousands of shoplifting offenses are handled without reports. An insurance company would not determine premium rates based solely on SFPD incident reports, nor should readers interpret SFPD shoplifting reports as anywhere near the total picture of the shoplifting epidemic in San Francisco. (this would also explain why one or two stores changing their reporting policy can produce a spike equal to everyone else in San Francisco combined) But comparing incident reports from 2010 to incident reports from 2020 should still be apples-to-apples, unless the likelihood of reporting any given incident changed in the meantime. Did it? This news article quotes a San Franciscan who says that when they try to report shoplifting incidents, the cops tell them not to because “it doesn’t make a difference”. If cops say that now more often than they used to, it would make all these statistics meaningless. (Applied Divinity Studies claims to have an argument that shows this can’t be true. It goes something like: if San Francisco was a better place to shoplift than its neighbors - eg Oakland - then shoplifters would leave Oakland to go to San Francisco, and we would see Oakland shoplifting rates falling. Oakland shoplifting rates are falling, but no more so than the rest of the state, so there can’t be increased tolerance for shoplifting in San Francisco. I find this dubious for many reasons. First of all, many of the same reasons shoplifting is up in San Francisco - like Prop 47 or soft-on-crime progressive policies - also apply to Oakland. Second, given that shoplifting fell massively everywhere because of the pandemic, it feels dubious to try to compare different cities; maybe one city had stricter pandemic lockdowns than others. Third, do criminals really shop around for friendly jurisdictions? If so, why are so many crimes like car break-ins, concentrated in “the bad part of town”? Why wouldn’t criminals leave the bad part of town for under-exploited areas with richer residents and less competition? Maybe criminals in fact aren’t very strategic or mobile? Maybe they don’t want to stand in the BART station and then take a half-hour train ride holding a bag of stolen goods?) Maybe a better argument against this being true is how stable the shoplifting rates have been over time. Wouldn’t it be weird if (let’s say) a tripling of the real shoplifting rates was matched by a third-ing of the reporting rates (rather than a halving or a quartering or whatever)? On the other hand, here’s Shellenberger with some helpful data: Some of this is probably because of Proposition 47, which made some forms of shoplifting punishable with citation rather than arrest (but wouldn’t that be a clear discontinuity rather than a gradual trend?) But overall it sure seems like shoplifting is being taken less seriously, which might encourage people to report less. Another statistic I see is that only 2.3% of shoplifting cases result in an arrest; I don’t know how this is different from the graph above with numbers in the 30s; maybe it involves different levels of what makes something a “case”. I accept that the data don’t consistently show a spike in shoplifting. But what’s the alternative? My patient who works in loss prevention in SF stores is lying to me? The nice elderly Chinese man who sold me my last pair of glasses and chatted to me about the rampant shoplifting in his mall was lying? The San Francisco police are lying? Walgreens pretends to be concerned about shoplifting as part of a dastardly plot to close a bunch of stores for no reason? Target and CVS pretend to care about shoplifting as part of a plot to restrict their stores’ opening hours for no reason? Every big store near me has suddenly gotten a security guard at the front as part of some corporate-sponsored jobs program? Maybe the conservative narrative that soft-on-crime San Francisco must be experiencing rising crime rates took on a life of its own. Maybe it infiltrated not just the usual suspects like the SF police unions, but even such supposedly-liberal bastions as the New York Times. Maybe lots of big corporations took advantage of the fake narrative to make unpopular business decisions they were planning on making anyway. And maybe ordinary San Franciscans, confronted with everyone telling them they were in a shoplifting epidemic, started paying more attention to security guards and petty criminals who had always been there, a sort of mass hallucination that gripped everyone in the city. I can’t rule this out. Americans thought crime was rising all throughout the early 2000s, when it was in fact way down. Or maybe some statistics that we already know are off by several orders of magnitude got off by an additional factor of two or so. I think this one is more likely, but I’m genuinely not sure. Other Crime From the Economist: The Center on Juvenile And Criminal Justice puts it even more starkly, arguing that “San Francisco’s ‘Crime Wave’ Is Just One Crime”: This are potentially susceptible to the same reporting bias as shoplifting. So what about homicide? Homicide is practically always reported and investigated, making it a gold standard in crime measurement. (source) Looks pretty good until 2019. I don’t expect to gain useful information post-2020; the pandemic and the post-George-Floyd murder surge will make it impossible to evaluate for local variation. What about compared to other places? For some reason this top 20 table fails to list Washington DC, which should be just before Atlanta. SF doesn’t make the top 20, although its neighbor Oakland does. Probably most murder variation in US cities is explained by percent African-American and maybe percent Borderer; with relatively few people in these groups SF was never in the running. I’m not sure if some abstracted version of the city with all demographic factors adjusted away would have an unusually high murder rate, but at that point it would be pretty distant from any interesting real-world question. You can see the leaderboard for other types of crime here; San Francisco is often in the top ten, but never the top three. As far as I can tell, San Francisco has seen a big spike in car breakins over the past few years, with no clear trend for other property crime, violent crime, or homicides. It’s not an outlier among American cities in any kind of crime. Conclusion of this section: San Fransicko’s specific claims are basically correct, but suggest a medium-term rise in SF crime which is mostly contradicted by the data. These show stable-to-decreasing murder, stable-to-decreasing violent and property crimes other than car break-ins, and large rises in car break-ins only. The data also show stable-to-decreasing shoplifting, but I’m not sure how much to trust them vs. common sense. Honestly, I’m pretty confused here and not sure what to think. Claim 7: Jim Jones (Of Kool-Aid Cult Fame) Used To Be The Chairman Of SF’s Housing Authority Okay, this isn’t really a statistical claim that I can research different perspectives on. Still, it’s so wacky that I couldn’t resist mentioning it in this review. Jim Jones, famous for killing everyone in his Guyana-based Jonestown cult with poisoned Kool-Aid, used to be the SF government’s top guy on homelessness. Shellenberger writes: Jones married and moved first to Northern California and then to San Francisco with his wife to start a church. He called it the People’s Temple. Jones believed he was the leader of a socialist revolution. He warned of nuclear war and claimed black people would be put in concentration camps. He became a hugely charismatic preacher among African Americans, the disaffiliated poor, and young transplants to the city looking for community. Scenes from the era show a remarkably large and diverse congregation smiling and singing. The People’s Temple grew and provided services. Jones cultivated two progressive San Francisco politicians, George Moscone and Willie Brown, and mobilized people to volunteer for their campaigns […] His son and a San Francisco historian believe he stole the mayoral election for Moscone in 1975. Historian David Talbot, founder of the progressive website Salon, points to evidence that Jones committed sufficient voter fraud to account for Moscone’s narrow 4,443-vote margin of victory. “We loaded up all thirteen of our buses with maybe seventy people on each bus, and we had those buses rolling nonstop up and down the coast into San Francisco the day before the election,” said Jones Jr. “Could we have been the force that tipped the election to Moscone? Absolutely! Slam dunk. He only won by four thousand votes.” When federal investigators looked into fraud claims three years later, they discovered that all of the records were missing from the city of San Francisco’s registrar of voters. Jones also boasted of providing Moscone with black women from his congregation for sex. One time Moscone, drunk and “accompanied by a young black woman whom the politician had kindly agreed to drive home,” crashed into another car. Another time, Moscone and Willie Brown “were with a black woman in an alley at two in the morning at some restaurant in North Beach,” said a local bar owner. State legislator “John Burton was part of that gang too. They were all using marijuana and cocaine.” Said Jones Jr., Moscone would “always be there at temple parties with a cocktail in his hand and doing some ass grabbing.” A Temple member overheard Jones speaking to Moscone the day after one of those parties saying, “I want to let you know that the young lady you went off with is underage,” adding, “Now don’t worry, Mayor, we’ll take care of you—because we know that you’ll take care of us.” Afterward, Moscone made Jones the chairman of the powerful San Francisco Housing Commission. Jones cultivated progressives with money and favors. He made large donations to the ACLU, the NAACP, and United Farm Workers. Jones and Moscone met privately with vice presidential candidate Walter Mondale on a campaign plane a few days before the 1976 presidential election, and Mondale praised People’s Temple shortly afterward. Jones met with First Lady Rosalynn Carter several times. Governor Jerry Brown praised Jones. Glide Memorial Church’s Rev. Cecil Williams loved Jones. There is a photo from 1977 of a smiling Williams awarding Jones the church’s “Martin Luther King, Jr. Award.” Jones used his perch as chairman of the Housing Commission to fight for housing for the poor. He tried to use eminent domain to acquire the International Hotel, a single resident occupancy hotel. After a court sided with the hotel’s owner, Jones mobilized seven thousand protesters to picket it. By mid-January 1977, the situation had become heated. There were rumors that protesters inside the building were armed with guns and Molotov cocktails. Jones lost the legal battle in 1977, and the tenants were evicted. But the drama was a publicity victory for Jones, which burnished his image as a white savior. A conservative member of the Board of Supervisors who was defeated in the mayoral election by Moscone accused the new mayor, the San Francisco Chronicle, and the rest of the city establishment of being blind to Jones’s extremism. “There’s no radical plot in San Francisco,” insisted Moscone, in response. “There’s no one I’ve appointed to any city position whom I regard as radical or extremist.” Willie Brown, a powerful state legislator from 1964 to 1995 before becoming mayor in 1996, “seemed oblivious to Jones’ hucksterism and demagoguery,” notes a historian. Brown was master of ceremonies at a dinner for Jones in the fall of 1976 attended by an adulatory crowd of the rich and powerful, including Governor Jerry Brown. “Let me present to you a combination of Martin King, Angela Davis, Albert Einstein . . . Chairman Mao,” he said, to loud applause. And yet Jones was contemptuous of Brown even as Brown did Jones more and more favors. Jones mocked Brown for his designer suits, sports cars, and women. Once, while Brown was addressing the congregation and Jones was seated onstage behind him, Jones flipped his middle finger up to mock him. San Francisco’s establishment stood by Jones even after a California magazine, New West, owned by Rupert Murdoch, published an exposé of Jones’s beatings of Temple members and financial abuses in August 1977. The article was written by a San Francisco Chronicle reporter and was meant for the Chronicle to publish. But the newspaper killed the story because it didn’t want to alienate Jones, whom it viewed as central to its plans to expand the Chronicle’s circulation in the heavily African American Fillmore District. Jones also managed to avoid investigation and prosecution in part by getting the district attorney to hire as deputy district attorney Jones’s longtime attorney and confidant. Progressives defended Jones against the New West article. At a rally in the summer of 1977, Willie Brown said, “When somebody like Jim Jones comes on the scene, that absolutely scares the hell out of most everybody occupying positions of power in the system.” Angela Davis sent a radio message broadcast over the cult’s compound, Jonestown, in Guyana. “I know you’re in a very difficult situation right now,” she said, “and there is a very profound conspiracy designed to destroy the contributions which you have made to the struggle.” After visiting Jonestown, the attorney to the Black Panthers said, “I have seen paradise.” Harvey Milk, too, was tarnished by his association with Jones. In the fall of 1977, Milk wrote to President Carter’s secretary of health, education, and welfare requesting that Social Security checks be sent to elderly Temple members in Guyana. “People’s Temple,” wrote Milk, has “established a beautiful retirement community in Guyana.” In truth, the cult was disintegrating. Jones separated families and lovers, pitted relatives against each other, and forced neighbors to inform on each other. Jones sent people who violated the rules to solitary confinement in “the Box,” an underground cubicle where people were held as prisoners for days on end. Others were drugged. Progressives who had spent thirty years fighting to close prisons and mental hospitals found themselves praising a man who had reproduced their worst practices. In November 1978 a Bay Area congressman flew to Guyana to investigate human rights violations at Jonestown with NBC News. Jones gave the delegation a formal reception at Jonestown. A Temple member surreptitiously passed a note to one of the delegation members, saying he and another member wanted to escape. They fled the next day after a Temple member tried to stab the congressman. Jones didn’t prevent them from leaving but then sent gunmen to fire machine guns at the delegation at the airport, killing the congressman and four others. A few hours later, 907 inhabitants of Jonestown drank Flavor Aid laced with cyanide and died. Two-thirds of the victims were African American and one-third were children. Jones had told them that if they didn’t drink it they would be killed by invading soldiers from a shadowy global military conspiracy intent on imposing fascism and torturing children. As people started crying in grief, Jones scolded them. “Stop these hysterics,” he said. “This is not the way for people who are socialists or communists to die.” Jones’s wife protested the murder of children and had to be forcibly restrained. “We didn’t commit suicide,” said Jones in a tape recording, “we committed an act of revolutionary suicide protesting the conditions of an inhumane world.” Few were as stained by Jonestown as Willie Brown and George Moscone. “Even as the bloated bodies of the dead were removed from the jungle and the wounded were airlifted by the U.S. Air Force to hospitals in the United States,” wrote a historian, “Brown said he had ‘no regrets’ over his association with Jones.” They repeatedly disavowed responsibility. Said Moscone, “it’s clear that if there was a sinister plan, then we were taken in. But I’m not taking any responsibility. It’s not mine to shoulder.” This is Shellenberger at his best: telling us crazy stories from the recesses of San Francisco history, maybe kind of spinning the narration in a way that makes all progressives seem guilty by association, but with the tale itself so gripping that it’s hard to be mad. And Jones wasn’t alone. This was the golden age of San Francisco cults, when (Shellenberger tells us) “more than half of all high school students in the San Francisco Bay Area reported at least one recruiting attempt by a cult member, and 40 percent reported at least three contacts.” This chapter of SF history came to an end in 1978, when Dan White, who had just resigned from San Francisco’s Board Of Supervisors (ie City Council) entered City Hall through a window and assassinated Mayor Moscone and fellow Supervisor Harvey Milk, then successfully got charges reduced to manslaughter through a legal manuever that has gone down in history as “the Twinkie Defense” (realistically the defense was that he was depressed, but reporters seized on a comment that implied it was because he ate too many Twinkies). Everything about 1970s San Francisco was like this. With the Mayor and his right-hand-man both dead, San Francisco leadership ended up in the hands of previously second-tier politician Dianne Feinstein. Feinstein was what passed for a moderate in 1970s SF (which meant she had been targeted for assassination by various left-wing groups - she survived when a bomb left on her windowsill failed to explode). In Shellenberger’s telling, she managed to clean up some of the mess and restore a semblance of normalcy. San Francisco never forgave her. Moscone - voting fraud committer, underage sex enjoyer, and Jim Jones’ bff - is beloved as a martyr in today’s SF, but (the book points out) Feinstein is so loathed that in 2021 the Board of Education voted to rename Dianne Feinstein Elementary School. The Moscone Center is 2 million square feet and can fit about 10,000 people. Not to be confused with the Moscone Recreation Center, Moscone Station, or Moscone Elementary School. Meanwhile, all Dianne Feinstein got was one lousy elementary school and the Tithonus package of eternal life without eternal youth. Claim 8: The Intolerant Left Shuts Down Debate On These Issues Another one that’s probably hard to do a randomized controlled trial on. You could probably predict that this one was coming - it’s a necessary narrative beat in this genre of book. I think this beat is good. My impression is that people who aren’t themselves public figures disagreeing with left-wing ideas still don’t understand how scary it is and how much hate you get. Maybe now that 2/3s of every political essay written over the past five years is about this topic, people will finally get it through their thick skulls that it exists and is bad. I would also note that “traumatizing the sorts of people who write popular books about politics, in a such a way that they feel compelled as a sort of self-therapy to write page after page telling readers how angry they should be at you and your whole coalition” isn’t great political praxis. I would like people to figure this out and stop doing it. Anyway, Shellenberger is doing his part in this effort: In 2001, the San Francisco Coalition on Homelessness wheat-pasted posters of a fake front-page San Francisco Chronicle across town. Just beneath the masthead a large headline read “Fuck the Homeless!” right above a picture of San Francisco mayor Willie Brown laughing. Below his photo was the headline “Save the Tourists.” Progressives level the same charges at people thirty years later. “Because of some of the stuff I say,” said a community activist in Seattle’s historically black Capitol Hill neighborhood, “people say, ‘Oh, she’s not for them.’ But I have a heart for homeless and mentally ill. Most of my family works with the mentally ill.” Noted a Chronicle journalist in 2017, “Inevitably, homeless advocates and others will say, ‘You’re not compassionate,’” in response to stories about homeless encampments. “They called me a racist,” said Tom. “They accused me, a guy who used to be homeless, of demonizing the homeless, because I’m asking for accountability.” I found myself similarly accused. In 2019, after I published an article for Forbes about the homeless crisis, a progressive homeless activist accused me on Twitter of having written my article to “make money off of a fear tactic” of “fueling hatred [and] even increasing violence against homeless people.” After I asked the former San Francisco supervisor for the Tenderloin neighborhood, former mayoral candidate Jane Kim, how such a progressive city ended up with so much suffering, she said, “My concern, Michael, just to be very honest, is that when that kind of messaging goes out, violence against people who are unhoused goes up.” […] I soon discovered in my research that I was hardly the first person that progressive elected officials and homelessness advocates had accused of fomenting violence against unhoused people. Many others had been criticized for far worse over the years, including San Francisco’s highest elected officials. “The criticism [by progressive homelessness advocates] was heavy, political and personal,” wrote former mayor Willie Brown in his 2008 memoir. “People accused me of abandoning the problem when I was working daily to try and get a solution going. It was brutal. . . . I had become demonized, and my own efforts belittled.” It is notable that the result of such personal attacks is to frighten off people seeking to change, and perhaps improve, the situation. “The problem” of homelessness, concluded Mayor Brown within nine months of entering office, “may not be solvable.” And [Quoting Chris Rufo]. “The chief of psychiatry in a public hospital system in one of the largest California cities told me, ‘I know for a fact, and all of my colleagues know, that what we actually need to deal with the problem in the biggest cities in California is long-term residential secure psychiatric care. But I can’t say that publicly because I would be disemboweled by the activist left. My job would be in jeopardy. My reputation would be in jeopardy. My whole life would get turned upside down for even broaching the subject of expanding secure mental health facilities and compulsory mental health treatment.’ And I said, ‘So what’s the solution?’ and this person said, ‘We muddle through.’” And: In San Francisco, radical left activists protested [African-American] Mayor London Breed in front of her home. Breed said the protesters were “all white people. But that didn’t bother me as much as the taunting of me coming outside with firework torches in their hands looking like what used to happen when the KKK would show up to black people’s houses to burn their houses down.” While I was reading the book, I came across this tweet, which suggests that being unimpressed with SF’s lefty homeless activist scene is not limited to Michael Shellenberger: Claim 9: European Cities Like Amsterdam Successfully Solved Their Own Drug And Homelessness Problems By Doing The Opposite Of SF Shellenberger bases his plan to solve these problems on ideas that he says were pioneered in Amsterdam and spread to other European cities. In the 1980s, Amsterdam had the kinds of problems San Francisco deals with now: open-air drug markets, overdose deaths, homelessness, and crime. But in the 90s, they admitted they had a problem and took decisive action: What’s the secret?” I asked him. “Amsterdam has decriminalized marijuana and many other drugs but I haven’t seen any homeless. What is San Francisco doing wrong?” Rene said that in the 1980s, the Zeedijk neighborhood in Amsterdam was a lot like the Tenderloin [the worst part of San Francisco] today. There was open-air drug use, particularly of heroin, and needles strewn about, as well as crime. People started to flee the neighborhood, worsening its slum conditions. Homeless people squatted in abandoned buildings. “We had ghettos where it was not safe to go,” said Rene, who started working in the neighborhood as a nurse in 1985. It was considered a “no go” zone. “We had a lot of people from abroad who came to Amsterdam because our heroin was so good. But our heroin was so good that they died from it.” At first the city tried a “helping approach” exclusively, offering addicts clean needles, methadone, and other forms of help without any law enforcement, but it didn’t work. “In the eighties we just wanted to help people,” said Rene. “We started with methadone programs and medical treatment. We did a lot of work without much of a carrot and a stick. It was really a disappointment. They just used the methadone to stay addicted. They dealt drugs and committed other crimes. They lied and cheated about it. We were just supporting a different kind of market. We had to learn the hard way [...] The Amsterdam City Council asked the Amsterdam Municipal Health Service to develop a strategy to deal with “unmotivated drug users”...The police broke up the open-air drug scene and health workers were on hand to offer methadone, treatment, and shelter. The police broke up gatherings of more than four or five users, but did not treat personal and private use as a crime. Officers ticketed violators, and if users did not pay their fines, which was frequent, the courts ordered arrests, and sentenced individuals to follow a treatment plan or face incarceration. “For every individual homeless person, we make a plan,” said Rene. “We made tens of thousands of those plans.” Plans are overseen by a caseworker and a team that may include a psychiatrist, shelter provider, service provider, judge, employer, parole officer, and police officer. “You need people in the police and health department working together,” he said. What Amsterdam did was the same as other major European cities. Lisbon, Frankfurt, Vienna, and Zurich all dealt with their open-air drug markets, using a combination of law enforcement and social services. Crucially, Amsterdam and other European cities prevented services from being concentrated in a single neighborhood, since their concentration often enables an open-air drug scene to thrive [...] The efforts worked. “We had several thousand people who were addicted to heroin in the eighties and nineties,” said Rene. “Many died. Today we have four or five hundred people addicted to methadone. And we have about 120 in Amsterdam who we supply heroin to on a medical basis because methadone doesn’t work for them. They have to use heroin.” The Amsterdam strategy goes something like: Break up open-air drug markets and anywhere that more than 4-5 drug users are congregating. Yes, people can just use their drugs in private, but this is legitimately better. Open-air markets normalize drugs with their blatantness, and make it hard to quit for the same reason it’s hard to diet if your partner leaves boxes of donuts out in the house every day.
Inline links: here, LouB’s analysis here, This news article, only 2.3% of shoplifting cases result in an arrest, New York Times, the Economist, https://substackcdn.com/image/fetch/$s_!58I3!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2Fc63dc7bc-1f8e-49fd-9c68-61c85278d69e_608x662.png, San Francisco’s ‘Crime Wave’ Is Just One Crime, https://substackcdn.com/image/fetch/$s_!h17s!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F956c0917-2a9b-4ff7-a08e-6aee5030583a_590x376.png, https://substackcdn.com/image/fetch/$s_!TkFS!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F5c5faa01-ac22-48a2-96fe-47efb6f52514_616x334.png, source, https://substackcdn.com/image/fetch/$s_!Bg2w!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F18e49c63-16ba-4878-96e6-aec12d7c5953_481x667.png, percent African-American, percent Borderer, here, the Twinkie Defense, https://substackcdn.com/image/fetch/$s_!8wK3!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F683b9754-f663-47ad-88f5-aa99bc208ec8_1401x622.jpeg, https://twitter.com/weheartprez/status/1526983899309432832
Proposition L1 mentions across 1 issues

Proposition L is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between October 22, 2024 and October 22, 2024. The archive places it in contexts such as "Proposition L raises taxes on ride-share companies". It most often appears alongside ACX Chicago, ACX Oakland, Austin.

Reference entry
Proposition L
Mention count
1
Issue count
1
First seen
October 22, 2024
Last seen
October 22, 2024
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Source context
ACX Local Voting Guides
October 22, 2024 · Original source
SAN FRANCISCO: Guide here. I got confused because San Francisco has their own list of local propositions which are suspiciously similar to the statewide propositions (for example, both sets have an education bond first). That's not all that's confusing - California has a long history of propositions that invalidate past ballot propositions, but this is the first time I've ever seen them try this during the same election cycle. Proposition L raises taxes on ride-share companies, but Proposition M simplifies the tax system in various ways including cancelling Proposition L. If both pass, then whichever gets more votes wins. This creates a weird situation where several interest groups have strong opinions that both propositions should pass but that L should pass by more votes than M; how do you even make a voter guide for a situation like that? Maybe you should recommend stochastic voting - tell people to vote yes on L, then roll a die, and vote yes on M unless they get a 1? The San Francisco meetup group takes a simpler path and just recommends yes on both.
Inline links: Guide here, whichever gets more votes wins
Proposition M1 mentions across 1 issues

Proposition M is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between October 22, 2024 and October 22, 2024. The archive places it in contexts such as "Proposition M simplifies the tax system in various ways including cancelling Proposition L". It most often appears alongside ACX Chicago, ACX Oakland, Austin.

Reference entry
Proposition M
Mention count
1
Issue count
1
First seen
October 22, 2024
Last seen
October 22, 2024
Outbound links
Issue trail
Related pages
Source context
ACX Local Voting Guides
October 22, 2024 · Original source
SAN FRANCISCO: Guide here. I got confused because San Francisco has their own list of local propositions which are suspiciously similar to the statewide propositions (for example, both sets have an education bond first). That's not all that's confusing - California has a long history of propositions that invalidate past ballot propositions, but this is the first time I've ever seen them try this during the same election cycle. Proposition L raises taxes on ride-share companies, but Proposition M simplifies the tax system in various ways including cancelling Proposition L. If both pass, then whichever gets more votes wins. This creates a weird situation where several interest groups have strong opinions that both propositions should pass but that L should pass by more votes than M; how do you even make a voter guide for a situation like that? Maybe you should recommend stochastic voting - tell people to vote yes on L, then roll a die, and vote yes on M unless they get a 1? The San Francisco meetup group takes a simpler path and just recommends yes on both.
Inline links: Guide here, whichever gets more votes wins
proprioception1 mentions across 1 issues

proprioception is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between March 16, 2023 and March 16, 2023. The archive places it in contexts such as "a link between proprioception and reasoning styles". It most often appears alongside ACX survey, ACX Survey, ACX Survey Results.

Reference entry
proprioception
Mention count
1
Issue count
1
First seen
March 16, 2023
Last seen
March 16, 2023
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Source context
Why Do Transgender People Report Hypermobile Joints?
March 16, 2023 · Original source
My guess is something like joint issues → poor proprioception → all sensory experience is noisy and confusing → the brain, which is embodied and spends most of its time trying to process sensory experience, learns a different reasoning style → different reasoning style is less context-dependent (producing symptoms of autism) → different reasoning style when trying to interpret bodily correlates of gender (eg sex hormones) → transgender.
I continue to find theory 4.5 - a link between proprioception and reasoning styles which sometimes also produces autism - the most convincing.
propylene glycol vapor1 mentions across 1 issues

propylene glycol vapor is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between October 30, 2025 and October 30, 2025. The archive places it in contexts such as "propylene glycol vapor - ie the fog in fog machines - kills all germs". It most often appears alongside 767 AD, @Scientific_Bird, ACX.

Reference entry
propylene glycol vapor
Mention count
1
Issue count
1
First seen
October 30, 2025
Last seen
October 30, 2025
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Source context
Links For October 2025
October 30, 2025 · Original source
45: Andrew Snyder-Beattie on the latest advances in biodefense. Without having fully resolved the debate over the real-world utility of COVID-era masks and N95s, the next generation of masks - elastomeric respirators - seem significantly more effective, including for people not specially trained in wearing them. Also, propylene glycol vapor - ie the fog in fog machines - kills all germs. Having indoor spaces constantly enveloped in fog is a weird ask, but we might find ways to make it work for crucial infrastructure during a pandemic, and “the US already produces enough to cover all industrial and much residential floorspace.” More things I didn’t know: “In a worst-case scenario where all crops die instantly, the US has enough stockpiled food (including animal feed) to last at least 18 months.”
Inline links: Andrew Snyder-Beattie on the latest advances in biodefense
Prosperity Gospel1 mentions across 1 issues

Prosperity Gospel is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between August 02, 2021 and August 02, 2021. The archive places it in contexts such as "The whole movement is inextricably linked to the Prosperity Gospel". It most often appears alongside AgroAlpha, Alex Tabarrok, Amazon.

Reference entry
Prosperity Gospel
Mention count
1
Issue count
1
First seen
August 02, 2021
Last seen
August 02, 2021
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  • 21 August 02, 2021
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21
August 02, 2021 · Original source
There is a lot to dislike about Nigerian megachurches. The pastor of the Redemption organization, Enoch Adeboye, owns somewhat more private jets than you would expect from a humble man of God. And another Nigerian megapastor, Chris Oyakhilome, is known for spreading such Scripturally-inspired truths as “5G causes COVID”. The whole movement is inextricably linked to the Prosperity Gospel, which (although I am not a theologian) does not seem very Biblically accurate. They’re not subtle about it either - one of the top megachurches is called Winners Chapel (surprisingly, Donald Trump has yet to join).
Inline links: known for spreading, Winners Chapel
protein arginine1 mentions across 1 issues

protein arginine is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between March 28, 2024 and March 28, 2024. The archive places it in contexts such as "the furin cleavage site is weird. It uses the protein arginine twice". It most often appears alongside ACX comment thread, ACX subreddit, Asia.

Reference entry
protein arginine
Mention count
1
Issue count
1
First seen
March 28, 2024
Last seen
March 28, 2024
Outbound links
Issue trail
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Source context
Practically-A-Book Review: Rootclaim $100,000 Lab Leak Debate
March 28, 2024 · Original source
Lineage A (left) was used by the Minoan Cretans, but has never been deciphered. Lineage B (right) was used by the Mycaeneans for lists of palace goods. This matches Saar’s story above. The lab leaked to somewhere else in Wuhan, not the wet market. The virus spread undetected in the population for a while. During this time, it mutated to Lineage B. Then one of the people with Lineage B went to the wet market and started a superspreader event. The authorities sampled the patients, found Lineage B, then started looking elsewhere. Later they detected some of the earlier Lineage A cases. The market is unlikely to be the origin of the pandemic, because the original Lineage A strain wasn’t found there. Peter: Although Lineage A is evolutionarily older, Lineage B started spreading in humans first. We know this because Lineage B is more common. Throughout the early pandemic, until the D614G variant drove all other strains extinct, a consistent 2/3 of the cases were B, compared to 1/3 A. Both strains spread at the same rate, so the best explanation is that B started earlier than A. Since COVID doubles every 3-4 days, probably Lineage B started 3-4 days earlier than Lineage A, which explains why it’s always been twice as many cases. But also, Lineage B also has more internal genetic diversity than Lineage A. In general, older viruses have more genetic diversity (the “molecular clock”). This is further evidence that B started spreading first. Pekar 2022 and Pipes 2021 do analyses with known parameters for spread rate and diversity, and find 90%+ odds that Lineage B was the first one in humans. Why did the older strain start spreading later? Probably the virus crossed from bats into raccoon-dogs on some raccoon-dog farm out in the country. It spread in the raccoon-dogs for a while, racking up mutations, including the (less mutated) Lineage A strain and the (slightly more mutated) Lineage B strain. Then several raccoon-dogs were taken to Wuhan for sale, including one with Lineage A and another with Lineage B. The one with Lineage B passed its virus to humans earlier. Then 3-4 days later, the Lineage A one passed its virus to humans. Lineage A was first found in a Wuhan neighborhood right next to the wet market (closer to the wet market than 97% of Wuhan’s population). Again, it would be a bizarre coincidence if a lab leak pandemic was first detected at a wet market. But it would be an even more bizarre coincidence if a lab leak pandemic separated into two strains, and both were first detected at a wet market! Although no known wet market cases were Lineage A, a positive Lineage A environmental sample was found at the wet market, and everyone agrees most cases went undetected. So maybe the Lineage B raccoon-dog spread its virus to a vendor, and that sub-strain mostly stayed in the market. But the Lineage A raccoon-dog spread its virus to a customer, who went back to his house nearby, and that strain spread in the neighborhoods next to the market. This is the only story that explains the evolutionary precedence of A, the greater spread and older molecular clock of B, and the fact that both strains were first found very close to the wet market. Yuri/Saar: Lineage B could be more common and diverse because it got the advantage of a super-spreader event in the wet market. There are a few scattered cases of intermediates between A and B, and a few other scattered cases of lineages that seem even more ancestral (ie closer to the bat virus) than either. This doesn’t make sense in a double spillover hypothesis. But it does make sense if the lineages separated in human transmission somewhere between the lab and the first super-spreader event at the wet market. Peter: Again, the wet market wasn’t a super-spreader event. COVID spread in the wet market at exactly its normal spread rate, doubling about once every 3.5 days. Stop calling the wet market a super-spreader event. The scattered cases of “intermediates” are sequencing errors. They were all found by the same computer software, which “autofills” unsequenced bases in a genome to the most plausible guess. Because Lineage B was already in the software, depending on which part of a Lineage A virus you sequenced, you might get one half or the other autofilled as Lineage B, which looked like an “intermediate”. We know this because all the supposed “intermediates” were partial cases sequenced by this particular software. We can confirm this by noting that there are too many intermediates! That is, where Lineage A is (T/C) and Lineage B is (C/T), the software found both (T/T) “intermediates” and (C/C) “intermediates”. But obviously there can only be one real intermediate form, and we have to dismiss one or the other. But in fact we can dismiss both, because they were both caused by the same software bug. The scattered “progenitor” cases - those closer to the ancestral bat virus than either A or B - are reversions, ie cases where a new mutation in the virus happened to hit an already-mutated base and shift it back towards the ancestral virus. We know this because all of these “progenitors” were scattered cases found months after the pandemic started, often in entirely different countries from Wuhan. If these were real progenitor viruses, they would have either fizzled out or exploded into a substantial portion of all cases, not be found one time in one guy in Malaysia. Given the number of mutations the virus developed over the course of the pandemic, it’s inevitable that some of them would be mutations that bring it closer to the original bat virus, and in fact we find the number of “progenitors” found very nicely matches the number of progenitor-appearing viruses we would expect by chance. And in many cases, we know the “progenitors” are newer than the original lineages, because they also have some of the later mutations that Lineage A or B picked up along the way, alongside their apparent ancestral-bat-virus-like mutations. Session 2: Viral Genetics Yuri: Two years before COVID, scientists at the Wuhan Institute of Virology, together with colleagues at the University of North Carolina, sent in a grant proposal for the DEFUSE program. This program, intended to locate and better understand potential future pandemic viruses, involved going into bat caves and collecting new coronaviruses. Once they had them, they would do gain-of-function: specifically, they would add a furin cleavage site to make them more infectious and see what happened. (quick interlude: COVID’s spike protein has two sections: one binds to human cells through the ACE2 receptor, the other helps fuse with the cell after binding. In order to avoid the immune system, it hides both of these into one spike. But when it reaches a cell, it needs to separate them again. It takes advantage of a human respiratory enzyme, furin, to do the separation - this also ensures that it only infects its primary target, human respiratory cells. The part of COVID that lets it get separated by furin is called the “furin cleavage site”. COVID’s bat-virus ancestors were gastrointestinal viruses; the addition of a furin cleavage site was what made them respiratory viruses.) We’ve found two close relatives of COVID: bat viruses called RATG-13 and BANAL-52. In particular, COVID looks more or less like BANAL-52 plus a furin cleavage site. There are 1500 sarbecoviruses, members of the family of viruses that includes SARS and SARS2/COVID. None of them except COVID have furin cleavage sites. BANAL-52, COVID’s closest ancestor, doesn’t even have anything resembling one that could mutate into a functional furin cleavage site like COVID’s. Instead, COVID - which mostly just resembles BANAL-52 with a few scattered single-point mutations - has twelve completely new nucleotides in a row - a fully formed furin cleavage site that came out of nowhere. There is nowhere else in the genome that COVID differs from BANAL-52 in such a profound way. It’s just BANAL-52 plus a little bit of random mutation plus a fully-formed furin cleavage site that came out of nowhere. Further, the furin cleavage site is weird. It uses the protein arginine twice. But instead of the nucleotides coding for arginine in the usual viral way, both times it uses the codons CGG - the way that higher animals code for arginine. This works fine - it’s just not how viruses do it. So the obvious conclusion is that WIV, which said in 2018 that it was going to find viruses and add furin cleavage sites to them, found a close relative of BANAL-52 and added a furin cleavage site. Since they were humans, and most familiar with the human way of encoding arginine, they added it as CGG both times. COVID seemed surprisingly optimized for infecting humans. Of fifty animals it was tested in, including the usual coronavirus intermediate hosts (pangolins, raccoon-dogs, etc), it was best at infecting human cells. Further, a virus that enters a new species will usually show a burst of mutations as it “figures out” the best way to adapt to that species’ unique biology. But COVID has had a pretty constant mutation rate in humans, from the beginning of the pandemic to the end. That suggests it was already adapted to humans. This could be because the lab screened for viruses with existing adaptations, because they passed it through humanized mice in the lab, or because it adapted in the hundreds of undetected cases that happened between the lab and detection in the wet market. Usually, research with potentially dangerous coronaviruses is done in BSL-3 or 4, ie high to very-high security. But WIV was irresponsibly doing it in BSL-2, ie medium security. The researchers weren’t even required to wear masks. In general, about 1/500 labs will leak any given pathogen they’re working on (?!). But because WIV was researching such an infectious virus in such an irresponsible way, the odds of a leak were much higher. The most likely explanation for all these facts is that WIV went ahead and did the gain-of-function research they said they were going to do (the particular DEFUSE grant proposal we know about got rejected, but it proves that Wuhan wanted to do this, and they could easily have gotten funding somewhere else, or done it out of their regular budget). They found a close relative of BANAL-52 and added a furin cleavage site as a simple twelve-nucleotide insertion, using the human method of encoding arginine that their genetic engineers were familiar with. Then it leaked, spread for a while in the general Wuhan population, and eventually made it to the wet market where it got detected. Peter: As mentioned earlier, the DEFUSE grant was rejected. Further, the grant said that the Wuhan Institute of Virology was responsible for finding the viruses, and the University of North Carolina would do all the gain-of-function research. This was a reasonable division of labor, since UNC was actually good at gain-of-function research, and WIV mostly wasn’t. They had done a few very simple gain-of-function projects before, but weren’t really set up for this particular proposal and were happy to leave it for their American colleagues. Even if WIV did try to create COVID, they couldn’t have. As Yuri said, COVID looks like BANAL-52 plus a furin cleavage site. But WIV didn’t have BANAL-52. It wasn’t discovered until after the COVID pandemic started, when scientists scoured the area for potential COVID relatives. WIV had a more distant COVID relative, RATG-13. But you can’t create COVID from RATG-13; they’re too different. You would need BANAL-52, or some as-yet-undiscovered extremely close relative. WIV had neither. Are we sure they had neither? Yes. Remember, WIV’s whole job was looking for new coronaviruses. They published lists of which ones they had found pretty regularly. They published their last list in mid-2019, just a few months before the pandemic. Although lab leak proponents claimed these lists showed weird discrepancies, this was just their inability to keep names consistent, and all the lists showed basically the same viruses (plus a few extra on the later ones, as they kept discovering more). The lists didn’t include BANAL-52 or any other suitable COVID relatives - only RATG-13, which isn’t close enough to work. Could they have been keeping their discovery of BANAL-52 secret? No. Pre-pandemic, there was nothing interesting about it; our understanding of virology wasn’t good enough to point this out as a potential pandemic candidate. WIV did its gain-of-function research openly and proudly (before the pandemic, gain-of-function wasn’t as unpopular as it is now) so it’s not like they wanted to keep it secret because they might gain-of-function it later. Their lists very clearly showed they had no virus they could create COVID from, and they had no reason to hide it if they did. COVID’s furin cleavage site is admittedly unusual. But it’s unusual in a way that looks natural rather than man-made. Labs don’t usually add furin cleavage sites through nucleotide insertions (they usually mutate what’s already there). On the other hand, viruses get weird insertions of 12+ nucleotides in nature. For example, HKU1 is another emergent Chinese coronavirus that caused a small outbreak of pneumonia in 2004. It had a 15 nucleotide insertion right next to its furin cleavage site. Later strains of COVID got further 12 - 15 nucleotide insertions. Plenty of flus have 12 to 15 nucleotide insertions compared to other earlier flu strains. Sometimes insertions happen because of a mistake in viral replication. Other times the virus gets confused between its own RNA and its host’s, and splices a bit of the host RNA into the virus. This would neatly explain why the insertion used the unusual coding CGG for arginine, which is common in animals but rare in viruses. On the other hand, it’s not that rare in viruses - COVID uses CGG for arginine about 3% of the time. And human engineers don’t necessarily use it any more than that - Peter was able to find one example of humans adding arginine to a virus, and 0 out of the 5 arginines added were CGG. COVID’s furin cleavage site is a mess. When humans are inserting furin cleavage sites into viruses for gain-of-function, the standard practice is RRKR, a very nice and simple furin cleavage site which works well. COVID uses PRRAR, a bizarre furin cleavage site which no human has ever used before, and which virologists expected to work poorly. They later found that an adjacent part of COVID’s genome twisted the protein in an unusual way that allowed PRRAR to be a viable furin cleavage site, but this discovery took a lot of computer power, and was only made after COVID became important. The Wuhan virologists supposedly doing gain-of-function research on COVID shouldn’t have known this would work. Why didn’t they just use the standard RRKR site, which would have worked better? Everyone thinks it works better! Even the virus eventually decided it worked better - sometime during the course of the pandemic, it mutated away from its weird PRRAR furin cleavage site towards a more normal form. Further, COVID’s furin cleavage site was inserted via what seems to be a frameshift mutation - it wasn’t a clean insertion of the amino acids that formed the site, it was an insertion of a sequence which changed the context of the surrounding nucleotides into the amino acids that formed the site. This is a pointless too-clever-by-half “flourish” that there would be no reason for a human engineer to do. But it’s exactly the kind of weird thing that happens in the random chance of evolution. COVID is hard to culture. If you culture it in most standard media or animals, it will quickly develop characteristic mutations. But the original Wuhan strains didn’t have these mutations. The only ways to culture it without mutations are in human airway cells, or (apparently) in live raccoon-dogs. Getting human airway cells requires a donor (ie someone who donates their body to science), and Wuhan had never done this before (it was one of the technologies only used at the superior North Carolina site). As for raccoon-dogs, it sure does seems suspicious that the virus is already suited to them. The claim that COVID is uniquely adapted to humans is false. The paper that claimed that defined how well COVID was adapted to different animals by those animals’ difference (on the relevant cell receptors) from humans. So in its methodology, humans came out #1 by default. If you don’t do that, COVID is better-adapted to many other animals. It’s not necessarily true that viruses see a burst of mutations when they enter a new host. COVID spread to deer and mink, and in neither case was there a burst of mutations. COVID has a pretty simple job of infecting respiratory cells and is already very good at it, regardless of species. In Yuri’s model, Wuhan Institute of Virology picked up a discarded grant and decided to do the gain-of-function half allotted to a different university, despite their relative inexperience. They skipped over all the SARS-like viruses they were supposed to work on, and all the standard gain-of-function model backbones, in favor of BANAL-52, a virus which would not be discovered for another two years, but which they somehow had samples of, which they had for some reason decided to keep secret despite its total lack of interestingness. Then they would have had to eschew all usual gain-of-function practices in favor of inserting a weird furin cleavage site that shouldn’t have worked according to the theory they had at the time, via a frameshift mutation. Then they would have had to culture it, a technique beyond their limited capabilities. Then it would have had to leak, and magically show up again in front of the raccoon-dog stall at a wet market. Yuri: WIV wouldn’t have needed to keep BANAL-52 “secret” in some kind of sinister way. Plenty of researchers have backlogs of work they haven’t published yet. Probably they a found BANAL relative in one of their normal sampling trips, did some preliminary studies on it, and planned to publish it later once they cleaned up their data. Everyone works like this. The part of DEFUSE saying that they would only work on viruses that were 95% similar to SARS is unclear and might mean something else. It looks more like they say they’ll start with those viruses, but also do some work on novel viruses. BANAL-52 could have been one of the novel viruses. The furin cleavage site is weird, but the researchers might have done that on purpose, to make the virus easier to keep track of, or to test different furin cleavage sites. Depending on the exact BANAL-52 relative they used, it might not even be a frameshift; there’s a particular way to spell serine that would make the insertion more natural. The claims that COVID can’t be cultured in normal media are based on speculative original research by Peter and might not hold up. Peter: WIV did most of its virus-gathering in a trip to a Yunnan cave between 2010 and 2015. All those viruses have long since been processed and added to the database. There’s no sign that they made more trips to Yunnan caves, and no reason for them to keep that secret. So the idea that they might just have some new viruses they didn’t publish doesn’t hold up. But suppose they did make more trips. Given the amount of time between the DEFUSE proposal and COVID, if they kept to their normal virus-collection rate, they would have gotten about thirty new viruses. What’s the chance that one of those was BANAL-52? There are thousands of bat viruses, and BANAL-52 is so rare that it wasn’t found until well after the pandemic started and people were looking for it very hard. So the chance that one of their 30 would be BANAL-52 is low. Also, they said in DEFUSE that they planned to go back to the same Yunnan cave. But BANAL-52 was found far away from that cave, so unless it ranged over a wide area, they probably couldn’t have found it even if they got very lucky. Session 3: Closing Arguments This third debate was supposed to be about “inference”, ie how much Bayesian evidence was provided by each of the facts given so far, and how to fit them into the Rootclaim probabilistic model. I’m going to relegate my summary of the more probabilistic half to the next section of this post, and just include the closing arguments here. Saar: Peter’s case hinges on the idea that it’s very improbable that a lab leak pandemic would first show up at a wet market. But this isn’t necessarily improbable. The Huanan Seafood Market had several factors that made it a likely location for a superspreader event. It was busy, with over 10,000 visitors a day. Many of the people there (eg the 1,000 vendors) came back daily, letting them reinfect each other. It had poor ventilation, especially in the high-positivity area near the raccoon-dog stall. It had cold wet surfaces on which the virus could survive for long periods. It was indoors, which prevented UV light from killing the virus. Given a small amount of sporadic COVID going around Wuhan, it’s not surprising for the first place it started spreading en masse to be a wet market. In fact, we have several examples of this. When China was COVID Zero, there would occasionally be small outbreaks that the authorities would have to contain. Most of these were at wet markets. For example, the big COVID outbreak in Beijing started at Xinfadi Market, their local seafood market. This couldn’t be an animal spillover, because there were no raccoon-dogs or other weird wildlife there. So it must be that wet markets are natural places for superspreader events. There are several other examples, which make up about half of the total outbreaks in Zero COVID era China, plus others in Singapore and Thailand. Since COVID clusters concentrate in wet markets even when there is no animal spillover, we should accept this as a property of the virus, and not attribute any significance to the fact that this happened in Wuhan too. Peter: About 1/10,000 citizens of Wuhan was a wet market vendor. So there’s a 1/10,000 chance that the first known COVID case should be a wet market vendor by chance alone. Weibo lists the most popular places for people to check in to their network on their phones, and the wet market was the 1600th most popular place in Wuhan, meaning that if you weight locations by busy-ness, there’s a less than 1/1600 chance that the first cases would be in the wet market. Yes, the wet market is indoors, has mediocre ventilation, has repeat visitors, etc. So do thousands of other places in Wuhan, like schools, hospitals, workplaces, places of worship. The wet market isn’t special in any way. And again, it wasn’t a superspreader event! COVID spread at the same rate in the wet market as it does everywhere else: doubling once per 3.5 days. It doesn’t matter what kinds of arguments you can come up with for why the wet market should have been the perfect superspreader event location, we can look at it and see that it wasn’t. It’s an environment that spreads COVID at exactly the normal rate. Zero COVID era Chinese outbreaks were concentrated in wet markets because they received infected animal products. We know why there was an outbreak in the Xinfadi Market in Beijing: it was because the seafood stall got frozen fish from some non-Zero-COVID country, the fish had COVID particles on it, and the vendor got infected and spread it to everyone else. Something like this is true for the other Chinese wet market based outbreaks we know about it. So this makes the opposite point you think it does: wet markets start outbreaks because there are infected goods being sold there. Then the virus spreads through the wet market at a completely normal rate. Saar: The Weibo list of 1600 places bigger than the wet market is likely inaccurate, because it's based on check-in data and people don't check in to seafood markets. Most of those 1600 places aren't amenable to superspread. The 70 markets supposedly bigger than Huanan are irrelevant, because they're supermarkets, open air markets, etc. Huanan is the largest seafood market in central China, and a more likely place for the first cluster of cases to be noticed. Markets weren't a common spillover location in SARS1, so the zoonosis hypothesis hasn't "called" this event in a way that should give them a high Bayes factor. And there’s still plenty of evidence for isolated (though not super-spreading) pre-market cases. A British expatriate in Wuhan, Connor Reed, says he got sick in November, three weeks before the first wet market case. Later the hospital tested his samples and said it was COVID. Another paper reports 90 cases before the first wet market one. Peter: Connor Reed was lying. The case wasn’t reported in any peer-reviewed paper. It was reported in the tabloid The Daily Mail, months after it supposedly happened. He also told the Mail that his cat died of coronavirus too, which is rare-to-impossible. Also, to get a positive hospital test, he would have had to go to the hospital, but he was 25 years old and almost no 25-year-olds go to the hospital for coronavirus. His only evidence that it was COVID was that two months later, the hospital supposedly “notified” him that it was. The hospital never informed anyone else of this extremely surprising fact which would be the biggest scientific story of the year if true. So probably he was lying. Incidentally, he died of a drug overdose shortly after giving the Mail that story; while not all drug addicts are liars, given all the other implausibilities in his story, this certainly doesn’t make him seem more credible. And in any case, he claimed he got his case at a market “like in the media” The other 90 cases are also fake. A lab leak guy found a paper that mentioned 90 more cases than other papers, and made up a conspiracy theory where the author was trying to secretly communicate that there had been 90 secret cases before any of the confirmed cases, even though there was nothing about this in the text of the paper. But actually that paper just counted cases differently than other papers, and they were referring to normal cases after the pandemic officially started. Again, I’ll come back to the discussion about inference later, but for now, here’s a table of both sides’ reasoning. This exact presentation comparing both analyses is mine3, but you can see Saar’s version here, and Peter’s starting at 45:33 of this video. Slightly made up; the two sides didn’t express their probabilities in the same way and I had to make editorial decisions to match them. Note that these aren't entirely comparable because Peter is being laxer about out-of-model probability than Saar. Although Saar's final odds here are 533-to-1, this just the central estimate. Rootclaim’s real final probability is 94% lab leak. You can see their analysis here. And The Winner Is . . . … … … … … Peter and the zoonosis hypothesis. This was a decisive victory. There were two judges, who each gave separate verdicts (or were allowed to declare a draw). Both judges decided in favor of Peter. You can see the judges’ own summary of their reasoning here (Will, Eric) Manifold agreed with the judges. There was a prediction market on who would win. It started out 70-30 in favor of lab leak. As the videos came out, zoonosis started doing better and better. I don’t want to take the exact final numbers too seriously, since I think some of the later price increases involved hints from the participants’ behavior. But it’s clear which way viewers thought the wind was blowing4. Around the same time, the Good Judgment Project - Philip Tetlock’s group studying superforecasters - put out a report on the lab leak hypothesis. After studying it in depth, his forecasters ended up 75-25 in favor of zoonosis. The Rootclaim debate was one of ten sources they said they found especially interesting. And also around the same time, and unrelated to any of this, the Global Catastrophic Risks Institute surveyed experts (“168 virologists, infectious disease epidemiologists, and other scientists from 47 countries”) and found the same thing (though see here for some potential problems with the survey): For what it’s worth, I was close to 50-50 before the debate, and now I’m 90-10 in favor of zoonosis. III. The Math And The Aftermath The third debate session was about “inference”, how to put evidence together. I put this part off until after disclosing the winner, because I wanted to talk about some of these issues at more length. The Math: Judges Both judges included a probabilistic analysis in their written decision. Here’s the same table as above, expanded to add the judges: I shoehorned the judges’ factors into the categories I already had; some of them were actually subtly different from Peter’s, Saar’s, and each other’s. The “priors” category is especially a mess here. We’ll go over these later, but I get the impression that they both thought of probabilistic analyses as an afterthought. For example, Judge Eric wrote 30,000 words about which considerations moved him, and only then includes the analysis, saying: I am not convinced that this Bayesian calculation is even an appropriate way to estimate the relative posterior probability of Z and LL; it just seemed fair that after criticizing Rootclaim’s calculations at length I should make an attempt at it myself. Judge Will’s decision ran to 10,000 words. He said he independently tried both reasoning it out intuitively, and running the Bayesian analysis, and was relieved when these two methods returned the same result. He said: I am skeptical that the Bayesian decision making/evaluation methods are any more "objective" than [intuitive reasoning]. I think they maximize legibility, not objectivity, and tend to hide the intuitive/heuristic portion in the data inclusion step and values, where it’s harder to see . . . I am not skilled in the Bayesian method, and I am sure I made significant mistakes. More time and practice would improve and refine my estimates. At the fundamental rules of the universe level, Bayesian analysis must be the best way to evaluate evidence. However, I am unsure that it’s a good strategy for a human given our cognitive limitations, and doubly unsure it’s truly being used (in the dispassionate sense) where the outcome is social desirability/fame/Twitter likes. I’m focusing on this because Saar’s opinion is that the debate went wrong (for his side) because he didn’t realize the judges were going to use Bayesian math, they did the math wrong (because Saar hadn’t done enough work explaining how to do it right), and so they got the wrong answer. I want to discuss the math errors he thinks the judges made, but this discussion would be incomplete without mentioning that the judges themselves say the numbers were only a supplement for their intuitive reasoning. That having been said, let’s look deeper into some of Saar’s concerns. The Math: Extreme Odds Saar complained that Peter’s odds were too extreme. For example, Peter said there was only a 1/10,000 chance that a lab leak pandemic would first show up at a wet market. Peter’s argument went something like: obviously a zoonotic pandemic would start at a site selling weird animals. But a lab leak pandemic - if it didn’t start at the lab - could show up anywhere. 1/10,000 Wuhan citizens work at the wet market. So if a lab leak was going to show up somewhere random, the wet market was a 1/10,000 chance. Saar had specific arguments against this, but he also had a more general argument: you should rarely see odds like 1/10,000 outside of well-understood domains. In his blog post, he gave this example: A prosecutor shows the court a statistical analysis of which DNA markers matched the defendant and their prevalence, arriving at a 1E-9 probability they would all match a random person, implying a Bayes factor near 1E9 for guilty. But if we try to estimate p(DNA|~guilty) by truly assuming innocence, it is immediately evident how ridiculous it is to claim only 1 out of a billion innocent suspects will have a DNA match to the crime scene. There are obviously far better explanations like a lab mistake, framing, an object of the suspect being brought by someone to the scene, etc. So the real p(wet market|lab leak) isn’t the 1/10,000 chance a pandemic arising in a random place hits the wet market, but the (higher?) probability that there’s something wrong with Peter’s argument. Then Saar tried to show specific things that might be wrong with Peter’s argument. I didn’t find his specific examples convincing. But maybe the question shouldn’t be whether I agreed with him. It should be whether I’m so confident he’s wrong that I would give it 10,000-to-1 odds. This makes total sense, it’s absolutely true, and I want to be really, really careful with it. If you take this kind of reasoning too far, you can convince yourself that the sun won’t rise tomorrow morning. All you have to do is propose 100 different reasons the sunrise might not happen. For example: The sun might go nova.
Inline links: Pekar 2022, Pipes 2021, says, 3, here, this video, https://substackcdn.com/image/fetch/$s_!8aU2!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F815fe32d-d7ea-401b-b3a2-d8cd25b52ee8_490x780.png, https://substackcdn.com/image/fetch/$s_!0Tm_!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fd0492f69-7b7e-4611-9d76-64ef8d7f59d5_511x511.png, Will, Eric, agreed, 4, put out a report on the lab leak hypothesis, https://substackcdn.com/image/fetch/$s_!g7k2!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F37f1b493-b556-41ec-925e-03f9d8bc26cb_1456x849.webp, surveyed experts, see here, https://substackcdn.com/image/fetch/$s_!Zejl!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fe9c88e87-b6ca-4c6d-840e-24da726f50b7_975x365.png, https://substackcdn.com/image/fetch/$s_!T5rV!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F4983e2cd-4151-42de-9685-08037ef7a8e8_635x788.png
Protestant1 mentions across 1 issues

Protestant is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between October 10, 2022 and October 10, 2022. The archive places it in contexts such as "but not the Protestant or Jewish ones". It most often appears alongside 9-11, Adraste, America.

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Protestant
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October 10, 2022
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October 10, 2022
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Highlights From The Comments On Columbus Day
October 10, 2022 · Original source
Moving onto Hanukkah - some commenters like odd anon question my description of it as coming from a Bible story. This isn’t going to get resolved here - Hanukkah comes from the Books of Maccabees, some of which are included in the Catholic and Eastern Orthodox conceptions of the Bible, but not the Protestant or Jewish ones.
Inline links: odd anon
The implications of Arianism for Mariology, which provides a sharp distinction between Catholicism/Orthodoxy and most Protestantism, are huge. If you're debating Mary's role in salvation, which we Catholics/Orthodox think is major and most Protestants don't (and which we fight about on the internet the way you fight about buying mosquito nets) you eventually run into the Christological answer given by Arius. If Jesus isn't fully God, then Mary can't be the mother of God, which we think is an important title, with a corresponding entitlement to special reverence.
Protestant Ethic1 mentions across 1 issues

Protestant Ethic is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between August 25, 2023 and August 25, 2023. The archive places it in contexts such as "Weber's Protestant Ethic". It most often appears alongside 5G, Acemoglu and Robinson, ACX comments.

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Protestant Ethic
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1
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1
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August 25, 2023
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August 25, 2023
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Your Book Review: Why Nations Fail
August 25, 2023 · Original source
Even if correct, it is much less interesting and useful than it appears. Epistemic status: I have a decade-old PhD in economics (not in the field of economic growth) and a handful of peer-reviewed papers in moderately-ranked journals. I'm not claiming to make any original technical points, or to give a comprehensive evaluation of the economic growth literature. My criticisms are largely straight from the authors' own mouths. 1. What is this book about? Why is it not very good? Acemoglu and Robinson (AR) argue that countries are rich or poor because of their political institutions, not culture, geography or policy ignorance. I'll do this as much as possible in AR’s own words. Why Nations Fail was written during the Arab Spring, so the preface begins with Egypt. Some stress that Egypt’s poverty is determined primarily by its geography, by the fact that the country is mostly a desert and lacks adequate rainfall, and that its soils and climate do not allow productive agriculture1. Others instead point to cultural attributes ... Egyptians, they argue, lack the same sort of work ethic and cultural traits that have allowed others to prosper, and instead have accepted Islamic beliefs that are inconsistent with economic success. A third approach, the one dominant among economists and policy pundits, is based on the notion that the rulers of Egypt simply don’t know what is needed to make their country prosperous, and have followed incorrect policies and strategies in the past. Unsurprisingly, those other economists and policy pundits turn out to be wrong and the authors turn out to be right. In this book we’ll argue that the Egyptians in Tahrir Square, not most academics and commentators, have the right idea. In fact, Egypt is poor precisely because it has been ruled by a narrow elite that have organized society for their own benefit at the expense of the vast mass of people. And the Egyptian lesson turns out to be general. Whether it is North Korea, Sierra Leone, or Zimbabwe, we’ll show that poor countries are poor for the same reason that Egypt is poor. Countries such as Great Britain and the United States became rich because their citizens overthrew the elites who controlled power and created a society where political rights were much more broadly distributed, where the government was accountable and responsive to citizens, and where the great mass of people could take advantage of economic opportunities. What are “institutions” anyway? (The economic and political kind, not the prison and mental hospital kind.) Basically, AR mean politics. The word "institutions" occurs over 1000 times in Why Nations Fail2. I'll just focus on how AR use it without worrying about the dictionary, different schools of economics, or other social sciences. They begin with what institutions do rather than what they are. Nogales, Arizona, is in the United States. Its inhabitants have access to the economic institutions of the United States, which enable them to choose their occupations freely, acquire schooling and skills, and encourage their employers to invest in the best technology, which leads to higher wages for them. They also have access to political institutions that allow them to take part in the democratic process, to elect their representatives, and replace them if they misbehave. The word is used dozens more times before ARattempt a more general definition. Each society functions with a set of economic and political rules created and enforced by the state and the citizens collectively. Economic institutions shape economic incentives: the incentives to become educated, to save and invest, to innovate and adopt new technologies, and so on. It is the political process that determines what economic institutions people live under, and it is the political institutions that determine how this process works. So while economic and political institutions can be separated, it is the political institutions that matter in the long run. The good kind of institutions that lead to economic growth are "inclusive", as opposed to "extractive". To be inclusive, economic institutions must feature secure private property, an unbiased system of law, and a provision of public services that provides a level playing field in which people can exchange and contract; it also must permit the entry of new businesses and allow people to choose their careers. ... such rights must exist for the majority of people in society. Political pluralism is necessary, but not sufficient without a strong centralised state. ... political institutions that distribute power broadly in society and subject it to constraints are pluralistic. ... the key to understanding why South Korea and the United States have inclusive economic institutions is not just their pluralistic political institutions but also their sufficiently centralized and powerful states. A telling contrast is with the East African nation of Somalia. I am still a bit hazy as to the relative importance of de jure written rules versus the de facto struggle for power. AR are somewhat circular: Politics is the process by which a society chooses the rules that will govern it. Politics surrounds institutions ... When there is conflict over institutions, what happens depends on which people or group wins out in the game of politics ... The political institutions of a society are a key determinant of the outcome of this game. They are the rules that govern incentives in politics. But overall, you could just say ‘politics’ and not be too far off. AR do this themselves occasionally. South Korea ended up with very different economic institutions than the North because different people with different interests and objectives made the decisions about how to structure society. In other words, South Korea had different politics. AR's academic reputation is based on statistical analysis, but Why Nations Fail tries to do narrative history, IMHO not very well. When Jeffrey Sachs reviewed the book, he complained: They never define their key variables with precision, present any quantitative data or classifications based on those definitions, or offer even a single table, figure, or regression line to demonstrate the relationships that they contend underpin all economic history. Instead, they present a stream of assertions and anecdotes about the inclusive or extractive nature of this or that institution. AR replied baldly: Sachs ... argues that we provide no evidence. Right, we do not in the book. But that’s because a book for a general audience is not the right forum for presenting academic research, and we spent many years of our lives precisely on writing academic papers providing exactly the sort of evidence. ... So yes, we don’t provide the econometric evidence in the book, which isn’t of course the right place to do it, but econometric evidence is abundantly loud in the way it speaks on these topics. So, don't expect Why Nations Fail to be an accessible explanation of AR's academic work, which is what I was hoping for when I first read it. What do they spend over 500 pages on then? Well, after the preface, there's fifteen chapters of, as Sachs says, "assertions and anecdotes". Not just about "the inclusive or extractive nature of this or that institution", to be fair, but how institutions can change at "critical junctures" such as the Black Death or colonisation, and why it can be in elites’ interests to block economic innovation if it threatens their power, so that growth under extractive institutions is unlikely to be sustained. These chapters are not particularly good – I found them poorly organised and repetitive – but not particularly bad, if you are willing to accept the underlying premise that institutions are the main determinant of economic growth. Cumulatively they have an effect similar to the Old Testament, if you are willing to accept the underlying premise that the fortunes of the nation of Israel are determined by the LORD. Only the second chapter, ‘Theories that Don't Work’, makes a sustained argument against alternative theories. Geography is disposed of by noting the stark differences at the US-Mexican, North-South Korean and East-West German borders, and the reversal of fortune by which the present day US and Canada only became richer than Mexico, Central and South America following European colonisation. Culture is hand-waved away with the assertion that institutions determine the any relevant cultural behaviours, not the other way around, referring to the same border examples, the rapid catch up of Catholic Europe despite Weber's Protestant Ethic, the malign influence of the European and Ottoman empires on Africa, the range of outcomes within the former British Empire, and the more European population of Argentina and Uruguay versus the US and Canada, or of Columbia versus Ecuador and Peru. Not a bad list of anecdotes, but one could equally well point to the cross-border success of Ashkenazi Jews, overseas Chinese, or Baltic and Volga Germans. Ignorance is simply dismissed with the assertion that "if ignorance were the problem, well-meaning leaders would quickly learn what types of policies increased their citizens’ incomes and welfare, and would gravitate toward those policies." Various good and bad policy changes are explained as the result of political pressures rather than improved knowledge. The implication seems to be that good policies are so obvious they don’t require expert knowledge or advice, or that the experts never get it wrong. This appears most implausible in the debate over socialism and economic planning. Writing off the entire Communist experience as simply another elite trying to preserve its power feels inadequate, especially considering that some distinguished bourgeois economists thought central planning was a plausible road to riches until quite late in the day. Genetics or race is not mentioned, but would presumably attract the same counterexamples as geography and culture. Another theory AR do not discuss is crude exploitation: while colonial empires are excoriated, it is for setting up persistent extractive political institutions rather than for a direct theft of resources. The prosperity of white-owned South African farms next to poverty-stricken Bantustans is explained by the better quality of the institutions available to whites under apartheid, not relative population densities and land quality. For the rest of the book, I'll just list a few nitpicks to signal I read the whole thing and know a bit of history, but feel free to skip this – the real evidence for AR's thesis is in their academic papers, and I'll discuss those in the next section. I think AR overrate the importance of the Glorious Revolution, to the point of claiming it "created the rule of law" – after all, Parliament had already deposed and executed a king, then brought back the king’s son on their own terms after a decade of republican government. No less a luminary than Edmund Burke asserted "The Revolution was made to preserve our ancient indisputable laws and liberties, and that ancient constitution of government which is our only security for law and liberty." Also, strong signs of British economic uniqueness – the abnormal growth of London and reliance on coal as a fuel – predated 1688.
Inline links: 1, 2, dictionary, schools, economics, social sciences, reviewed, replied, Protestant Ethic, planning, distinguished, bourgeois, Glorious Revolution, Edmund Burke, predated
Protestant Reformation1 mentions across 1 issues

Protestant Reformation is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between August 01, 2025 and August 01, 2025. The archive places it in contexts such as ""what does the Protestant Reformation look like?"". It most often appears alongside Africa, Agamemnon, Age of Empires II.

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Protestant Reformation
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1
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1
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August 01, 2025
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August 01, 2025
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Your Review: Joan of Arc
August 01, 2025 · Original source
Basilica: Look, leaving aside the age-old debate over free will and why God doesn't solve our problems for us - I realize "mysterious ways" is a cheap shot, but this is one of the hinge points of history. There's no reason to believe the English would stop rolling over France if they took Orleans, and no reason not to expect they'd hold on if they took it.93 If England rules France - or, more accurately, an Anglo-French King rules both - what does the Protestant Reformation look like? The colonization of the New World? The rise of democracy? If God wants to butterfly history into our path, there's a thousand different ways we could have missed the goal if the Hundred Years' War goes differently.
Inline links: 93
Protestant work ethic1 mentions across 1 issues

Protestant work ethic is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between August 05, 2022 and August 05, 2022. The archive places it in contexts such as "now in the West explicitly linked with the co-called Protestant work ethic". It most often appears alongside acedia, Against Nature, Anna Schaffner.

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Protestant work ethic
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1
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1
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August 05, 2022
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August 05, 2022
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Your Book Review: Exhaustion
August 05, 2022 · Original source
On the other hand, we have the exhortation to activity, which as we’ve seen has been a suggestion from at least the days of monks with acedia, but is now in the West explicitly linked with the co-called Protestant work ethic, with work and its resultant energy and meaning being thought of as a necessary good (Max Weber, the sociologist who coined the term, was also diagnosed with neurasthenia – it seems a wonder anything intellectual got done during this period). There’s a gender bias here; while women had the rest cure, men diagnosed in the late 19th Century might be prescribed a “West Cure” where they might, in Mitchell’s words, “engage in a sturdy contest with Nature” by spending time with cowboys and sleeping rough – something Billy Crystal also found helpful.
Inline links: West Cure, Billy Crystal
Proto-Indoeuropean1 mentions across 1 issues

Proto-Indoeuropean is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between April 22, 2021 and April 22, 2021. The archive places it in contexts such as "development and early spread of Proto-Indoeuropean and its immediate daughter languages". It most often appears alongside ACX, African Gray Parrots, Animal Cognition.

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Proto-Indoeuropean
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1
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1
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April 22, 2021
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April 22, 2021
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Your Book Review: Are We Smart Enough To Know How Smart Animals Are?
April 22, 2021 · Original source
Honorable mention: The Horse, Wheel, and Language, which weaves together linguistics, archaeology, history, poetics, and genetics (a teeny bit - but it was published right before a lot of this data became available) to give the most comprehensive view possible of the development and early spread of Proto-Indoeuropean and its immediate daughter languages. War won out as my recommendation for having both a wider scope and I thought a more deft weaving of multiple fields. HWL reads very much as the writing of a professional archaeologist who has dipped into other fields to better understand his work. There's a lot of detail about pot sherds and midden heaps and such, which can drag, even if you're interested in that kind of thing.
Proton1 mentions across 1 issues

Proton is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between February 21, 2025 and February 21, 2025. The archive places it in contexts such as "proton? Obviously, it is because otherwise complex nuclei wouldn't be stable". It most often appears alongside /r/slatestarcodex, ACX, Adrian.

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Proton
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1
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1
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February 21, 2025
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February 21, 2025
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Highlights From The Comments On Tegmark's Mathematical Universe
February 21, 2025 · Original source
1930: why is the neutron so similar in mass to the proton? Obviously, it is because otherwise complex nuclei wouldn't be stable, so you couldn't have chemistry and we wouldn't exist. But actually it was because they're both made of three light up/down quarks.
1970: why don't protons decay? You dummy, it's because otherwise the Earth would have disintegrated by now! But actually it was because baryon number conservation is enforced by the structure of the Standard Model.
Protozoa1 mentions across 1 issues

Protozoa is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between September 12, 2025 and September 12, 2025. The archive places it in contexts such as "Gelber freely applies to Protozoa concepts (reinforcement and approach response)". It most often appears alongside A Change of Heart, Abraham, Adams.

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Protozoa
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1
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September 12, 2025
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September 12, 2025
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Your Review: The Synaptic Plasticity and Memory Hypothesis
September 12, 2025 · Original source
Gershman, Balbi, Gallistel, and Gunawardena discuss some of the history of single-cell learning and related controversies (for example, does this really ‘count’ as learning and memory?) in a recent and readable review paper titled “Reconsidering the evidence for learning in single cells”. Although times are changing, in the mid-twentieth century there was serious resistance to the idea that single cells could learn and store memories. Beatrice Gelber was a pioneering scientist that studied learning in protozoa like paramecia. As Gershman et al. recount, she encountered substantial resistance to the idea that paramecia could exhibit sophisticated learning, even from other psychologists working on paramecia. Donald Jensen, one such psychologist, wrote:
Inline links: Reconsidering the evidence for learning in single cells, Beatrice Gelber
Gelber freely applies to Protozoa concepts (reinforcement and approach response) and situations (food presentation) developed with higher metazoan animals. I feel that such application overestimates the sensory and motor capabilities of this organism… If analogies are necessary, a more apt one might be that of an earthworm which crawls and eats its way through the earth, blundering onto food-rich soil and avoiding light, heat, and dryness. Gelber’s assertion loses its force when the blind, filter-feeding mode of life of Paramecia is considered.
Proud Boys1 mentions across 1 issues

Proud Boys is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between April 19, 2021 and April 19, 2021. The archive places it in contexts such as "BIDEN: Proud Boys. TRUMP: Proud Boys, stand back and stand by"; "instead of to the Proud Boys?". It most often appears alongside #Resistance, 1/2019 government shut down, 538.

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Proud Boys
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1
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April 19, 2021
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April 19, 2021
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Mantic Monday: Grading My Trump Predictions
April 19, 2021 · Original source
BIDEN: Proud Boys.
TRUMP: Proud Boys, stand back and stand by. But I’ll tell you what, somebody’s got to do something about Antifa and the left.
When asked to condemn white supremacists and militia groups, Trump immediately said "Sure". Wallace asked if he was willing to tell these groups to stand down. Trump said yes. Wallace kept pushing him in a way suggesting he wanted a message targeted at a specific group. Trump asked who specifically who specifically Wallace was asking him to say should stand down. Wallace started to say "white supremacists", but Biden interrupted with "Proud Boys". Trump said the Proud Boys should "stand back and stand by", which as far as I can tell is equivalent to "stand down", the specific thing Wallace kept trying to make him say even though he had already condemned everybody.
PRRAR1 mentions across 1 issues

PRRAR is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between March 28, 2024 and March 28, 2024. The archive places it in contexts such as "only 1/20 odds that they would add a proline in front to make it PRRAR". It most often appears alongside ACX comment thread, ACX subreddit, Asia.

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PRRAR
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1
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1
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March 28, 2024
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March 28, 2024
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Practically-A-Book Review: Rootclaim $100,000 Lab Leak Debate
March 28, 2024 · Original source
Lineage A (left) was used by the Minoan Cretans, but has never been deciphered. Lineage B (right) was used by the Mycaeneans for lists of palace goods. This matches Saar’s story above. The lab leaked to somewhere else in Wuhan, not the wet market. The virus spread undetected in the population for a while. During this time, it mutated to Lineage B. Then one of the people with Lineage B went to the wet market and started a superspreader event. The authorities sampled the patients, found Lineage B, then started looking elsewhere. Later they detected some of the earlier Lineage A cases. The market is unlikely to be the origin of the pandemic, because the original Lineage A strain wasn’t found there. Peter: Although Lineage A is evolutionarily older, Lineage B started spreading in humans first. We know this because Lineage B is more common. Throughout the early pandemic, until the D614G variant drove all other strains extinct, a consistent 2/3 of the cases were B, compared to 1/3 A. Both strains spread at the same rate, so the best explanation is that B started earlier than A. Since COVID doubles every 3-4 days, probably Lineage B started 3-4 days earlier than Lineage A, which explains why it’s always been twice as many cases. But also, Lineage B also has more internal genetic diversity than Lineage A. In general, older viruses have more genetic diversity (the “molecular clock”). This is further evidence that B started spreading first. Pekar 2022 and Pipes 2021 do analyses with known parameters for spread rate and diversity, and find 90%+ odds that Lineage B was the first one in humans. Why did the older strain start spreading later? Probably the virus crossed from bats into raccoon-dogs on some raccoon-dog farm out in the country. It spread in the raccoon-dogs for a while, racking up mutations, including the (less mutated) Lineage A strain and the (slightly more mutated) Lineage B strain. Then several raccoon-dogs were taken to Wuhan for sale, including one with Lineage A and another with Lineage B. The one with Lineage B passed its virus to humans earlier. Then 3-4 days later, the Lineage A one passed its virus to humans. Lineage A was first found in a Wuhan neighborhood right next to the wet market (closer to the wet market than 97% of Wuhan’s population). Again, it would be a bizarre coincidence if a lab leak pandemic was first detected at a wet market. But it would be an even more bizarre coincidence if a lab leak pandemic separated into two strains, and both were first detected at a wet market! Although no known wet market cases were Lineage A, a positive Lineage A environmental sample was found at the wet market, and everyone agrees most cases went undetected. So maybe the Lineage B raccoon-dog spread its virus to a vendor, and that sub-strain mostly stayed in the market. But the Lineage A raccoon-dog spread its virus to a customer, who went back to his house nearby, and that strain spread in the neighborhoods next to the market. This is the only story that explains the evolutionary precedence of A, the greater spread and older molecular clock of B, and the fact that both strains were first found very close to the wet market. Yuri/Saar: Lineage B could be more common and diverse because it got the advantage of a super-spreader event in the wet market. There are a few scattered cases of intermediates between A and B, and a few other scattered cases of lineages that seem even more ancestral (ie closer to the bat virus) than either. This doesn’t make sense in a double spillover hypothesis. But it does make sense if the lineages separated in human transmission somewhere between the lab and the first super-spreader event at the wet market. Peter: Again, the wet market wasn’t a super-spreader event. COVID spread in the wet market at exactly its normal spread rate, doubling about once every 3.5 days. Stop calling the wet market a super-spreader event. The scattered cases of “intermediates” are sequencing errors. They were all found by the same computer software, which “autofills” unsequenced bases in a genome to the most plausible guess. Because Lineage B was already in the software, depending on which part of a Lineage A virus you sequenced, you might get one half or the other autofilled as Lineage B, which looked like an “intermediate”. We know this because all the supposed “intermediates” were partial cases sequenced by this particular software. We can confirm this by noting that there are too many intermediates! That is, where Lineage A is (T/C) and Lineage B is (C/T), the software found both (T/T) “intermediates” and (C/C) “intermediates”. But obviously there can only be one real intermediate form, and we have to dismiss one or the other. But in fact we can dismiss both, because they were both caused by the same software bug. The scattered “progenitor” cases - those closer to the ancestral bat virus than either A or B - are reversions, ie cases where a new mutation in the virus happened to hit an already-mutated base and shift it back towards the ancestral virus. We know this because all of these “progenitors” were scattered cases found months after the pandemic started, often in entirely different countries from Wuhan. If these were real progenitor viruses, they would have either fizzled out or exploded into a substantial portion of all cases, not be found one time in one guy in Malaysia. Given the number of mutations the virus developed over the course of the pandemic, it’s inevitable that some of them would be mutations that bring it closer to the original bat virus, and in fact we find the number of “progenitors” found very nicely matches the number of progenitor-appearing viruses we would expect by chance. And in many cases, we know the “progenitors” are newer than the original lineages, because they also have some of the later mutations that Lineage A or B picked up along the way, alongside their apparent ancestral-bat-virus-like mutations. Session 2: Viral Genetics Yuri: Two years before COVID, scientists at the Wuhan Institute of Virology, together with colleagues at the University of North Carolina, sent in a grant proposal for the DEFUSE program. This program, intended to locate and better understand potential future pandemic viruses, involved going into bat caves and collecting new coronaviruses. Once they had them, they would do gain-of-function: specifically, they would add a furin cleavage site to make them more infectious and see what happened. (quick interlude: COVID’s spike protein has two sections: one binds to human cells through the ACE2 receptor, the other helps fuse with the cell after binding. In order to avoid the immune system, it hides both of these into one spike. But when it reaches a cell, it needs to separate them again. It takes advantage of a human respiratory enzyme, furin, to do the separation - this also ensures that it only infects its primary target, human respiratory cells. The part of COVID that lets it get separated by furin is called the “furin cleavage site”. COVID’s bat-virus ancestors were gastrointestinal viruses; the addition of a furin cleavage site was what made them respiratory viruses.) We’ve found two close relatives of COVID: bat viruses called RATG-13 and BANAL-52. In particular, COVID looks more or less like BANAL-52 plus a furin cleavage site. There are 1500 sarbecoviruses, members of the family of viruses that includes SARS and SARS2/COVID. None of them except COVID have furin cleavage sites. BANAL-52, COVID’s closest ancestor, doesn’t even have anything resembling one that could mutate into a functional furin cleavage site like COVID’s. Instead, COVID - which mostly just resembles BANAL-52 with a few scattered single-point mutations - has twelve completely new nucleotides in a row - a fully formed furin cleavage site that came out of nowhere. There is nowhere else in the genome that COVID differs from BANAL-52 in such a profound way. It’s just BANAL-52 plus a little bit of random mutation plus a fully-formed furin cleavage site that came out of nowhere. Further, the furin cleavage site is weird. It uses the protein arginine twice. But instead of the nucleotides coding for arginine in the usual viral way, both times it uses the codons CGG - the way that higher animals code for arginine. This works fine - it’s just not how viruses do it. So the obvious conclusion is that WIV, which said in 2018 that it was going to find viruses and add furin cleavage sites to them, found a close relative of BANAL-52 and added a furin cleavage site. Since they were humans, and most familiar with the human way of encoding arginine, they added it as CGG both times. COVID seemed surprisingly optimized for infecting humans. Of fifty animals it was tested in, including the usual coronavirus intermediate hosts (pangolins, raccoon-dogs, etc), it was best at infecting human cells. Further, a virus that enters a new species will usually show a burst of mutations as it “figures out” the best way to adapt to that species’ unique biology. But COVID has had a pretty constant mutation rate in humans, from the beginning of the pandemic to the end. That suggests it was already adapted to humans. This could be because the lab screened for viruses with existing adaptations, because they passed it through humanized mice in the lab, or because it adapted in the hundreds of undetected cases that happened between the lab and detection in the wet market. Usually, research with potentially dangerous coronaviruses is done in BSL-3 or 4, ie high to very-high security. But WIV was irresponsibly doing it in BSL-2, ie medium security. The researchers weren’t even required to wear masks. In general, about 1/500 labs will leak any given pathogen they’re working on (?!). But because WIV was researching such an infectious virus in such an irresponsible way, the odds of a leak were much higher. The most likely explanation for all these facts is that WIV went ahead and did the gain-of-function research they said they were going to do (the particular DEFUSE grant proposal we know about got rejected, but it proves that Wuhan wanted to do this, and they could easily have gotten funding somewhere else, or done it out of their regular budget). They found a close relative of BANAL-52 and added a furin cleavage site as a simple twelve-nucleotide insertion, using the human method of encoding arginine that their genetic engineers were familiar with. Then it leaked, spread for a while in the general Wuhan population, and eventually made it to the wet market where it got detected. Peter: As mentioned earlier, the DEFUSE grant was rejected. Further, the grant said that the Wuhan Institute of Virology was responsible for finding the viruses, and the University of North Carolina would do all the gain-of-function research. This was a reasonable division of labor, since UNC was actually good at gain-of-function research, and WIV mostly wasn’t. They had done a few very simple gain-of-function projects before, but weren’t really set up for this particular proposal and were happy to leave it for their American colleagues. Even if WIV did try to create COVID, they couldn’t have. As Yuri said, COVID looks like BANAL-52 plus a furin cleavage site. But WIV didn’t have BANAL-52. It wasn’t discovered until after the COVID pandemic started, when scientists scoured the area for potential COVID relatives. WIV had a more distant COVID relative, RATG-13. But you can’t create COVID from RATG-13; they’re too different. You would need BANAL-52, or some as-yet-undiscovered extremely close relative. WIV had neither. Are we sure they had neither? Yes. Remember, WIV’s whole job was looking for new coronaviruses. They published lists of which ones they had found pretty regularly. They published their last list in mid-2019, just a few months before the pandemic. Although lab leak proponents claimed these lists showed weird discrepancies, this was just their inability to keep names consistent, and all the lists showed basically the same viruses (plus a few extra on the later ones, as they kept discovering more). The lists didn’t include BANAL-52 or any other suitable COVID relatives - only RATG-13, which isn’t close enough to work. Could they have been keeping their discovery of BANAL-52 secret? No. Pre-pandemic, there was nothing interesting about it; our understanding of virology wasn’t good enough to point this out as a potential pandemic candidate. WIV did its gain-of-function research openly and proudly (before the pandemic, gain-of-function wasn’t as unpopular as it is now) so it’s not like they wanted to keep it secret because they might gain-of-function it later. Their lists very clearly showed they had no virus they could create COVID from, and they had no reason to hide it if they did. COVID’s furin cleavage site is admittedly unusual. But it’s unusual in a way that looks natural rather than man-made. Labs don’t usually add furin cleavage sites through nucleotide insertions (they usually mutate what’s already there). On the other hand, viruses get weird insertions of 12+ nucleotides in nature. For example, HKU1 is another emergent Chinese coronavirus that caused a small outbreak of pneumonia in 2004. It had a 15 nucleotide insertion right next to its furin cleavage site. Later strains of COVID got further 12 - 15 nucleotide insertions. Plenty of flus have 12 to 15 nucleotide insertions compared to other earlier flu strains. Sometimes insertions happen because of a mistake in viral replication. Other times the virus gets confused between its own RNA and its host’s, and splices a bit of the host RNA into the virus. This would neatly explain why the insertion used the unusual coding CGG for arginine, which is common in animals but rare in viruses. On the other hand, it’s not that rare in viruses - COVID uses CGG for arginine about 3% of the time. And human engineers don’t necessarily use it any more than that - Peter was able to find one example of humans adding arginine to a virus, and 0 out of the 5 arginines added were CGG. COVID’s furin cleavage site is a mess. When humans are inserting furin cleavage sites into viruses for gain-of-function, the standard practice is RRKR, a very nice and simple furin cleavage site which works well. COVID uses PRRAR, a bizarre furin cleavage site which no human has ever used before, and which virologists expected to work poorly. They later found that an adjacent part of COVID’s genome twisted the protein in an unusual way that allowed PRRAR to be a viable furin cleavage site, but this discovery took a lot of computer power, and was only made after COVID became important. The Wuhan virologists supposedly doing gain-of-function research on COVID shouldn’t have known this would work. Why didn’t they just use the standard RRKR site, which would have worked better? Everyone thinks it works better! Even the virus eventually decided it worked better - sometime during the course of the pandemic, it mutated away from its weird PRRAR furin cleavage site towards a more normal form. Further, COVID’s furin cleavage site was inserted via what seems to be a frameshift mutation - it wasn’t a clean insertion of the amino acids that formed the site, it was an insertion of a sequence which changed the context of the surrounding nucleotides into the amino acids that formed the site. This is a pointless too-clever-by-half “flourish” that there would be no reason for a human engineer to do. But it’s exactly the kind of weird thing that happens in the random chance of evolution. COVID is hard to culture. If you culture it in most standard media or animals, it will quickly develop characteristic mutations. But the original Wuhan strains didn’t have these mutations. The only ways to culture it without mutations are in human airway cells, or (apparently) in live raccoon-dogs. Getting human airway cells requires a donor (ie someone who donates their body to science), and Wuhan had never done this before (it was one of the technologies only used at the superior North Carolina site). As for raccoon-dogs, it sure does seems suspicious that the virus is already suited to them. The claim that COVID is uniquely adapted to humans is false. The paper that claimed that defined how well COVID was adapted to different animals by those animals’ difference (on the relevant cell receptors) from humans. So in its methodology, humans came out #1 by default. If you don’t do that, COVID is better-adapted to many other animals. It’s not necessarily true that viruses see a burst of mutations when they enter a new host. COVID spread to deer and mink, and in neither case was there a burst of mutations. COVID has a pretty simple job of infecting respiratory cells and is already very good at it, regardless of species. In Yuri’s model, Wuhan Institute of Virology picked up a discarded grant and decided to do the gain-of-function half allotted to a different university, despite their relative inexperience. They skipped over all the SARS-like viruses they were supposed to work on, and all the standard gain-of-function model backbones, in favor of BANAL-52, a virus which would not be discovered for another two years, but which they somehow had samples of, which they had for some reason decided to keep secret despite its total lack of interestingness. Then they would have had to eschew all usual gain-of-function practices in favor of inserting a weird furin cleavage site that shouldn’t have worked according to the theory they had at the time, via a frameshift mutation. Then they would have had to culture it, a technique beyond their limited capabilities. Then it would have had to leak, and magically show up again in front of the raccoon-dog stall at a wet market. Yuri: WIV wouldn’t have needed to keep BANAL-52 “secret” in some kind of sinister way. Plenty of researchers have backlogs of work they haven’t published yet. Probably they a found BANAL relative in one of their normal sampling trips, did some preliminary studies on it, and planned to publish it later once they cleaned up their data. Everyone works like this. The part of DEFUSE saying that they would only work on viruses that were 95% similar to SARS is unclear and might mean something else. It looks more like they say they’ll start with those viruses, but also do some work on novel viruses. BANAL-52 could have been one of the novel viruses. The furin cleavage site is weird, but the researchers might have done that on purpose, to make the virus easier to keep track of, or to test different furin cleavage sites. Depending on the exact BANAL-52 relative they used, it might not even be a frameshift; there’s a particular way to spell serine that would make the insertion more natural. The claims that COVID can’t be cultured in normal media are based on speculative original research by Peter and might not hold up. Peter: WIV did most of its virus-gathering in a trip to a Yunnan cave between 2010 and 2015. All those viruses have long since been processed and added to the database. There’s no sign that they made more trips to Yunnan caves, and no reason for them to keep that secret. So the idea that they might just have some new viruses they didn’t publish doesn’t hold up. But suppose they did make more trips. Given the amount of time between the DEFUSE proposal and COVID, if they kept to their normal virus-collection rate, they would have gotten about thirty new viruses. What’s the chance that one of those was BANAL-52? There are thousands of bat viruses, and BANAL-52 is so rare that it wasn’t found until well after the pandemic started and people were looking for it very hard. So the chance that one of their 30 would be BANAL-52 is low. Also, they said in DEFUSE that they planned to go back to the same Yunnan cave. But BANAL-52 was found far away from that cave, so unless it ranged over a wide area, they probably couldn’t have found it even if they got very lucky. Session 3: Closing Arguments This third debate was supposed to be about “inference”, ie how much Bayesian evidence was provided by each of the facts given so far, and how to fit them into the Rootclaim probabilistic model. I’m going to relegate my summary of the more probabilistic half to the next section of this post, and just include the closing arguments here. Saar: Peter’s case hinges on the idea that it’s very improbable that a lab leak pandemic would first show up at a wet market. But this isn’t necessarily improbable. The Huanan Seafood Market had several factors that made it a likely location for a superspreader event. It was busy, with over 10,000 visitors a day. Many of the people there (eg the 1,000 vendors) came back daily, letting them reinfect each other. It had poor ventilation, especially in the high-positivity area near the raccoon-dog stall. It had cold wet surfaces on which the virus could survive for long periods. It was indoors, which prevented UV light from killing the virus. Given a small amount of sporadic COVID going around Wuhan, it’s not surprising for the first place it started spreading en masse to be a wet market. In fact, we have several examples of this. When China was COVID Zero, there would occasionally be small outbreaks that the authorities would have to contain. Most of these were at wet markets. For example, the big COVID outbreak in Beijing started at Xinfadi Market, their local seafood market. This couldn’t be an animal spillover, because there were no raccoon-dogs or other weird wildlife there. So it must be that wet markets are natural places for superspreader events. There are several other examples, which make up about half of the total outbreaks in Zero COVID era China, plus others in Singapore and Thailand. Since COVID clusters concentrate in wet markets even when there is no animal spillover, we should accept this as a property of the virus, and not attribute any significance to the fact that this happened in Wuhan too. Peter: About 1/10,000 citizens of Wuhan was a wet market vendor. So there’s a 1/10,000 chance that the first known COVID case should be a wet market vendor by chance alone. Weibo lists the most popular places for people to check in to their network on their phones, and the wet market was the 1600th most popular place in Wuhan, meaning that if you weight locations by busy-ness, there’s a less than 1/1600 chance that the first cases would be in the wet market. Yes, the wet market is indoors, has mediocre ventilation, has repeat visitors, etc. So do thousands of other places in Wuhan, like schools, hospitals, workplaces, places of worship. The wet market isn’t special in any way. And again, it wasn’t a superspreader event! COVID spread at the same rate in the wet market as it does everywhere else: doubling once per 3.5 days. It doesn’t matter what kinds of arguments you can come up with for why the wet market should have been the perfect superspreader event location, we can look at it and see that it wasn’t. It’s an environment that spreads COVID at exactly the normal rate. Zero COVID era Chinese outbreaks were concentrated in wet markets because they received infected animal products. We know why there was an outbreak in the Xinfadi Market in Beijing: it was because the seafood stall got frozen fish from some non-Zero-COVID country, the fish had COVID particles on it, and the vendor got infected and spread it to everyone else. Something like this is true for the other Chinese wet market based outbreaks we know about it. So this makes the opposite point you think it does: wet markets start outbreaks because there are infected goods being sold there. Then the virus spreads through the wet market at a completely normal rate. Saar: The Weibo list of 1600 places bigger than the wet market is likely inaccurate, because it's based on check-in data and people don't check in to seafood markets. Most of those 1600 places aren't amenable to superspread. The 70 markets supposedly bigger than Huanan are irrelevant, because they're supermarkets, open air markets, etc. Huanan is the largest seafood market in central China, and a more likely place for the first cluster of cases to be noticed. Markets weren't a common spillover location in SARS1, so the zoonosis hypothesis hasn't "called" this event in a way that should give them a high Bayes factor. And there’s still plenty of evidence for isolated (though not super-spreading) pre-market cases. A British expatriate in Wuhan, Connor Reed, says he got sick in November, three weeks before the first wet market case. Later the hospital tested his samples and said it was COVID. Another paper reports 90 cases before the first wet market one. Peter: Connor Reed was lying. The case wasn’t reported in any peer-reviewed paper. It was reported in the tabloid The Daily Mail, months after it supposedly happened. He also told the Mail that his cat died of coronavirus too, which is rare-to-impossible. Also, to get a positive hospital test, he would have had to go to the hospital, but he was 25 years old and almost no 25-year-olds go to the hospital for coronavirus. His only evidence that it was COVID was that two months later, the hospital supposedly “notified” him that it was. The hospital never informed anyone else of this extremely surprising fact which would be the biggest scientific story of the year if true. So probably he was lying. Incidentally, he died of a drug overdose shortly after giving the Mail that story; while not all drug addicts are liars, given all the other implausibilities in his story, this certainly doesn’t make him seem more credible. And in any case, he claimed he got his case at a market “like in the media” The other 90 cases are also fake. A lab leak guy found a paper that mentioned 90 more cases than other papers, and made up a conspiracy theory where the author was trying to secretly communicate that there had been 90 secret cases before any of the confirmed cases, even though there was nothing about this in the text of the paper. But actually that paper just counted cases differently than other papers, and they were referring to normal cases after the pandemic officially started. Again, I’ll come back to the discussion about inference later, but for now, here’s a table of both sides’ reasoning. This exact presentation comparing both analyses is mine3, but you can see Saar’s version here, and Peter’s starting at 45:33 of this video. Slightly made up; the two sides didn’t express their probabilities in the same way and I had to make editorial decisions to match them. Note that these aren't entirely comparable because Peter is being laxer about out-of-model probability than Saar. Although Saar's final odds here are 533-to-1, this just the central estimate. Rootclaim’s real final probability is 94% lab leak. You can see their analysis here. And The Winner Is . . . … … … … … Peter and the zoonosis hypothesis. This was a decisive victory. There were two judges, who each gave separate verdicts (or were allowed to declare a draw). Both judges decided in favor of Peter. You can see the judges’ own summary of their reasoning here (Will, Eric) Manifold agreed with the judges. There was a prediction market on who would win. It started out 70-30 in favor of lab leak. As the videos came out, zoonosis started doing better and better. I don’t want to take the exact final numbers too seriously, since I think some of the later price increases involved hints from the participants’ behavior. But it’s clear which way viewers thought the wind was blowing4. Around the same time, the Good Judgment Project - Philip Tetlock’s group studying superforecasters - put out a report on the lab leak hypothesis. After studying it in depth, his forecasters ended up 75-25 in favor of zoonosis. The Rootclaim debate was one of ten sources they said they found especially interesting. And also around the same time, and unrelated to any of this, the Global Catastrophic Risks Institute surveyed experts (“168 virologists, infectious disease epidemiologists, and other scientists from 47 countries”) and found the same thing (though see here for some potential problems with the survey): For what it’s worth, I was close to 50-50 before the debate, and now I’m 90-10 in favor of zoonosis. III. The Math And The Aftermath The third debate session was about “inference”, how to put evidence together. I put this part off until after disclosing the winner, because I wanted to talk about some of these issues at more length. The Math: Judges Both judges included a probabilistic analysis in their written decision. Here’s the same table as above, expanded to add the judges: I shoehorned the judges’ factors into the categories I already had; some of them were actually subtly different from Peter’s, Saar’s, and each other’s. The “priors” category is especially a mess here. We’ll go over these later, but I get the impression that they both thought of probabilistic analyses as an afterthought. For example, Judge Eric wrote 30,000 words about which considerations moved him, and only then includes the analysis, saying: I am not convinced that this Bayesian calculation is even an appropriate way to estimate the relative posterior probability of Z and LL; it just seemed fair that after criticizing Rootclaim’s calculations at length I should make an attempt at it myself. Judge Will’s decision ran to 10,000 words. He said he independently tried both reasoning it out intuitively, and running the Bayesian analysis, and was relieved when these two methods returned the same result. He said: I am skeptical that the Bayesian decision making/evaluation methods are any more "objective" than [intuitive reasoning]. I think they maximize legibility, not objectivity, and tend to hide the intuitive/heuristic portion in the data inclusion step and values, where it’s harder to see . . . I am not skilled in the Bayesian method, and I am sure I made significant mistakes. More time and practice would improve and refine my estimates. At the fundamental rules of the universe level, Bayesian analysis must be the best way to evaluate evidence. However, I am unsure that it’s a good strategy for a human given our cognitive limitations, and doubly unsure it’s truly being used (in the dispassionate sense) where the outcome is social desirability/fame/Twitter likes. I’m focusing on this because Saar’s opinion is that the debate went wrong (for his side) because he didn’t realize the judges were going to use Bayesian math, they did the math wrong (because Saar hadn’t done enough work explaining how to do it right), and so they got the wrong answer. I want to discuss the math errors he thinks the judges made, but this discussion would be incomplete without mentioning that the judges themselves say the numbers were only a supplement for their intuitive reasoning. That having been said, let’s look deeper into some of Saar’s concerns. The Math: Extreme Odds Saar complained that Peter’s odds were too extreme. For example, Peter said there was only a 1/10,000 chance that a lab leak pandemic would first show up at a wet market. Peter’s argument went something like: obviously a zoonotic pandemic would start at a site selling weird animals. But a lab leak pandemic - if it didn’t start at the lab - could show up anywhere. 1/10,000 Wuhan citizens work at the wet market. So if a lab leak was going to show up somewhere random, the wet market was a 1/10,000 chance. Saar had specific arguments against this, but he also had a more general argument: you should rarely see odds like 1/10,000 outside of well-understood domains. In his blog post, he gave this example: A prosecutor shows the court a statistical analysis of which DNA markers matched the defendant and their prevalence, arriving at a 1E-9 probability they would all match a random person, implying a Bayes factor near 1E9 for guilty. But if we try to estimate p(DNA|~guilty) by truly assuming innocence, it is immediately evident how ridiculous it is to claim only 1 out of a billion innocent suspects will have a DNA match to the crime scene. There are obviously far better explanations like a lab mistake, framing, an object of the suspect being brought by someone to the scene, etc. So the real p(wet market|lab leak) isn’t the 1/10,000 chance a pandemic arising in a random place hits the wet market, but the (higher?) probability that there’s something wrong with Peter’s argument. Then Saar tried to show specific things that might be wrong with Peter’s argument. I didn’t find his specific examples convincing. But maybe the question shouldn’t be whether I agreed with him. It should be whether I’m so confident he’s wrong that I would give it 10,000-to-1 odds. This makes total sense, it’s absolutely true, and I want to be really, really careful with it. If you take this kind of reasoning too far, you can convince yourself that the sun won’t rise tomorrow morning. All you have to do is propose 100 different reasons the sunrise might not happen. For example: The sun might go nova.
Inline links: Pekar 2022, Pipes 2021, says, 3, here, this video, https://substackcdn.com/image/fetch/$s_!8aU2!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F815fe32d-d7ea-401b-b3a2-d8cd25b52ee8_490x780.png, https://substackcdn.com/image/fetch/$s_!0Tm_!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fd0492f69-7b7e-4611-9d76-64ef8d7f59d5_511x511.png, Will, Eric, agreed, 4, put out a report on the lab leak hypothesis, https://substackcdn.com/image/fetch/$s_!g7k2!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F37f1b493-b556-41ec-925e-03f9d8bc26cb_1456x849.webp, surveyed experts, see here, https://substackcdn.com/image/fetch/$s_!Zejl!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fe9c88e87-b6ca-4c6d-840e-24da726f50b7_975x365.png, https://substackcdn.com/image/fetch/$s_!T5rV!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F4983e2cd-4151-42de-9685-08037ef7a8e8_635x788.png
Okay, this one is just awful. It takes the risky gambit above - giving extreme odds to something - then doubles down on it by multiplying across twenty different stages to get a stupendously low probability of 1/5*10^25. If we believe this, it’s more likely that we win the lottery three times in a row than that we learn lab leak was true after all. Eliezer Yudkowsky calls this the Multiple Stage Fallacy. Even aside from the failure mode in the sunrise example above (where people are too reluctant to give strong probabilities), it fails because people don’t think enough about the correlations between stages. For example, maybe there’s only 1/10 odds that the Wuhan scientists would choose the suboptimal RRAR furin cleavage site. And maybe there’s only 1/20 odds that they would add a proline in front to make it PRRAR. But are these really two separate forms of weirdness, such that we can multiply them together and get 1/200? Or are scientists who do one weird thing with a furin cleavage site more likely to do another? Mightn’t they be pursuing some general strategy of testing weird furin cleavage sites? (For example, Yuri proposed that, because the scientists wanted to understand how pandemic coronaviruses originate in nature, they might deliberately pick more natural-looking features over more designed-looking ones, which would neatly explain many features seemingly inconsistent with lab leak. Is this a conspiracy theory? Rootclaim is able to successfully route around this question. If the probability of a feature happening in nature is X, then the probability of it happening in this variant of lab leak scenario is X * [chance that the scientists wanted to imitate nature). This gives it a (deserved) complexity penalty without ruling out this (non-zero and potentially important) possibility.) In any case, Peter didn’t care as much about probabilistic analysis as Saar, he didn’t make his case hinge on this slide, and he might have been kind of using it to troll Rootclaim (which definitely worked). He might not have been making any of the mistakes above. But anyone who took this slide seriously would end up dramatically miscalibrated. The Math: Big Pictures Another of Saar’s concerns with the verdict was that Peter was an extraordinary debater, to the point where it could have overwhelmed the signal from the evidence. It’s hard to watch the videos and not come away impressed. Peter seems to have a photographic memory for every detail of every study he’s ever read. He has some kind of 3D model in his brain of Wuhan, the wet market, and how all of its ventilation ducts and drains interacted with each other. Whenever someone challenged one of his points, he had a ten-slide PowerPoint presentation already made up to address that particular challenge, and would go over it with complete fluency, like he was reciting a memorized speech. I sometimes get accused of overdoing things, but I can’t imagine how many mutations it would take to make me even a fraction as competent as Peter was. Saar’s closing argument included the admission: Peter, I think everyone can agree, has much more knowledge on [COVID] origins than we do. He's invested much more time. He may be a much more talented researcher. He's much more into the details. He probably knows the best in the world on origins at this point. Once you’ve described your opponent that way in your closing argument, what’s left of your case? Saar thought a lot was left. Throughout the debate, he tried to make a point about how getting the inference right was more important than winning sub-sub-sub-debates about individual lines of evidence. Although Peter won most specific points of contention, Saar thought that if the judges could just keep their mind on the big picture, they would realize a lab leak was more likely. I’m potentially sympathetic to arguments like Saar’s. Imagine a debate about UFOs. Imaginary-Saar says “UFOs can’t be real, because it doesn’t make sense for aliens to come to Earth, circle around a few fields in Kansas, then leave without providing any other evidence of their existence.” Imaginary-Peter says “John Smith of Topeka saw a UFO at 4:52 PM on 6/12/2010, and everyone agrees he’s an honorable person who wouldn’t lie, so what’s your explanation of that?” Saar says “I don’t know, maybe he was drunk or something?” Peter says “Ha, I’ve hacked his cell phone records and geolocated him to coordinates XYZ, which is a mosque. My analysis finds that he’s there on 99.5% of Islamic holy days, which proves he’s a very religious Muslim. And religious Muslims don’t drink! Your argument is invalid!” On the one hand, imaginary-Peter is very impressive and sure did shoot down Saar’s point. On the other, imaginary-Saar never really claimed to have a great explanation for this particular UFO sighting, and his argument doesn’t depend on it. Instead of debating whether Smith could or couldn’t have been drunk, we need to zoom out and realize that the aliens explanation makes no sense. The problem was, Saar couldn’t effectively communicate what his big picture was. Neither deployed some kind of amazingly elegant prior. They both used the same kind of evidence. The only difference was that Peter’s evidence hung together, and Saar’s evidence fell apart on cross-examination. I think - not because Saar really explained it, but just reading between the lines - Saar thought the un-ignorable big picture evidence was the origin in a city with a coronavirus gain-of-function lab, and the twelve-nucleotide insertion in the furin cleavage site. To some degree, Peter just ate the loss on those questions. No matter how you slice it, it really is a weird coincidence that the epidemic started so close to Asia’s biggest coronavirus laboratory. Peter tried to deflect this - he pointed out there were other BSL-3 and BSL-4 laboratories in Beijing, Shanghai, Shenzhen, etc. But this was a rare question where he unambiguously came out looking worse - the other cities’ labs had much less coronavirus-specific research. Wuhan really was unique (aside from the other big coronavirus lab in North Carolina). Peter did better when he tried to control the damage: there are a couple hundred million people in the South Asian areas where people eat weird animals exposed to virus-infected bats, Wuhan has a population of about 12 million, so maybe 1.5% of all potential zoonotic pandemics should start in Wuhan. Peter tried to argue that Wuhan was a local trade center, so maybe we should up that to 5 - 10%. 5 - 10% coincidences aren’t that rare. Even 1.5% coincidences happen sometimes. Likewise, the furin cleavage site really does stand on a genetic map. I didn’t feel like either side did much math to quantify how weird it was. Naively, I might think of this as “30,000 bases in COVID, only one insertion, it’s in what’s obviously the most interesting place - sounds like 30,000-to-one odds against”. Against that, a virus with a boring insertion would never have become a pandemic, so maybe you need to multiply this by however much viral evolution is going on in weird caves in Laos, and then you would get the odds that at least one virus would have an insertion interesting enough to go global. Neither participant calculated this in a way that satisfied me (though see here for related discussion). Instead, Peter tried to undermine the furin argument by showing that, as surprising as the site was under a natural origin, it would be an even more surprising choice for human engineers. Saar argued it wasn’t - but because of his policy of giving adjusted-for-model-error odds, he only gave this a factor of 30 in his analysis. Since Peter gave it a higher factor of 50 in his analysis, it looked from the outside like Saar had already conceded this point, and the judges were mostly happy to go with Saar’s artificially-low estimate. The Math: Double Coincidences Saar brought up an interesting point halfway through the debate: you should rarely see high Bayes factors on both sides of an argument. That is, suppose you accept that there’s only a 1-in-10,000 chance that the pandemic starts at a wet market under lab leak. And suppose you accept there’s only a 1-in-10,000 chance that COVID’s furin cleavage site could evolve naturally. If lab leak is true, then you might find 1-in-10,000 evidence for lab leak. But it’s a freak coincidence that there was 1-in-10,000 evidence for zoonosis5. Likewise, if zoonosis is true, you might find 1-in-10,000 evidence for this true thing. But it’s a freak coincidence that there was 1-in-10,000 evidence for lab leak. Either way, you’re accepting that a 1-in-10,000 freak coincidence happened. Isn’t it more likely you’ve bungled your analysis? I was following along at home, and I definitely bungled this point; I had some high Bayes factors on both sides. I adjusted some of them downward based on Saar’s good point, but how far should we take it? Here I remember The Pyramid And The Garden: you can get very strong coincidences if you have many degrees of freedom, ie buy a lot of lottery tickets. So for example, suppose there are fifty things about a virus. You should expect at least one of those to have a one-in-fifty coincidence by pure chance. What about more than that? You might be able to get away with this by saying there are an infinite number of possible conspiracy theories, and some from that infinite set are brought into existence when a strong enough coincidence makes them plausible. For example, it’s really weird that John Adams and Thomas Jefferson both died on the 50th anniversary of the Declaration of Independence. If I wanted, I could form a conspiracy theory about a group of weird assassins obsessed with killing Founding Fathers on important dates, and then Jefferson and Adams’ deaths would be 1/10,000 evidence for that theory. But this is the Texas Sharpshooter Fallacy, which Saar warned against several times. I don’t know if “the virus started in Wuhan, which is where they’re doing this research” gets a Texas Sharpshooter penalty, or how high that penalty should be. But the furin cleavage site doesn’t - people were talking about lab leak before anyone noticed it. The Aftermath: Peter Peter seemed satisfied with the result, in an understated sort of way: It seemed like an interesting experiment in monetizing the debunking of a conspiracy theory. I think there's usually a big asymmetry where it's easy to get rich spreading bullshit (like, the top anti-vaxxers during the pandemic all made a million dollars a year on substack), but it's almost impossible to make money on debunking it. The Rootclaim challenge seemed like one rare case where the opposite was true. Beyond that, I don't know what it's good for. It does seem like there could be a positive social impact from more people understanding that the lab leak hypothesis is (almost certainly) false. The Aftermath: Saar Saar says the debate didn’t change his mind. In fact, by the end of the debate, Rootclaim released an updated analysis that placed an even higher probability on lab leak than when they started. In his blog post, he discussed the issues above, and said the judges had erred in not considering them. He respects the judges, he appreciates their efforts, he just thinks they got it wrong. Although he respected their decision, he wanted the judges to correct what he saw as mistakes in their published statements, which delayed the public verdict and which which Viewers Like You did not appreciate: I ran an early draft of this post by him. There was some miscommunication about the exact publication date, so he hasn’t had time to write up a full response, but he has some quick thoughts (and I’ll link the full response when he writes it). He says: We will provide a full response to this post soon, but the main problem with it is fairly simple: There is general agreement that the main evidence for zoonosis is HSM (Huanan Seafood Market) forming an early cluster of cases. The contention is whether it is amazing 10,000x evidence, or is it negligible. All other evidence points to a lab leak, and if HSM is shown to be weak, lab leak is a clear winner. We provided an analysis of why it is negligible that is as close to mathematical proof as such things can be. Read it here. Scott and I exchanged a few emails on this issue and Scott preferred to discuss more intuitive analyses of HSM, using rules of thumb that likely served him well in the past. While I believe I managed to mostly explain where these failed, and Scott understands HSM is far weaker evidence than he initially thought6, he still has a very strong intuitive feeling (based on years of dealing with probabilities) that this is some exceptional coincidence, and that prevents him from properly updating his posterior. At the end of the day, this cannot be settled without going through our semi-formal derivation, understanding it, and either identifying the problem with it or accepting it (and thereby accepting lab-leak to be more likely). Here is a quick summary of the mistakes made by those claiming HSM is strong evidence: The first mistake is conflating Bayes factors with conditional probabilities. 1/10000 is the supposed conditional probability p(HSM|Lab Leak), That should be divided by the conditional probability of HSM under Zoonosis. Markets were not identified as a high-risk location prior to this outbreak (This will be elaborated in the full response), and in SARS1 the spillovers were mostly at restaurants and other food handlers that deal more closely with wildlife. While it's cool to point to the raccoon dog photo, that was a result of a retrospective search (we don't know what other photos they took which in retrospect would be brought up as premonition). Unbiased data shows markets are not a likely spillover location for zoonosis. We originally estimated p(HSM|Zoonosis)<0.1. Following more research we did to answer Scott's questions, this is more likely <0.03.
Inline links: Multiple Stage Fallacy, see here, 5, The Pyramid And The Garden, Texas Sharpshooter Fallacy, blog post, 6
prudence1 mentions across 1 issues

prudence is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between September 20, 2024 and September 20, 2024. The archive places it in contexts such as "Four of these virtues they inherited from Greek philosophy and they represent the practical and straightforward virtues that any rational man is likely to find worthwhile: prudence, temperance, justice, and fortitude". It most often appears alongside Adam, Alfred, Ballad.

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prudence
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September 20, 2024
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September 20, 2024
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Your Book Review: The Ballad of the White Horse
September 20, 2024 · Original source
Critics of virtue ethics will often question how you can know what virtues the virtue ethicist should cultivate. In Catholic theology there is no such problem, as they have seven official virtues specified. Four of these virtues they inherited from Greek philosophy and they represent the practical and straightforward virtues that any rational man is likely to find worthwhile: prudence, temperance, justice, and fortitude. Added to these four were three virtues unique to Christianity, believed to be revelations from God that mankind would not identify if left to their own devices. These three are faith, hope, and love.
Inline links: virtue ethics, Four of these virtues, three virtues
Prunus Amygdalus Dulcis1 mentions across 1 issues

Prunus Amygdalus Dulcis is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between September 04, 2025 and September 04, 2025. The archive places it in contexts such as "sweet almond oil is Prunus Amygdalus Dulcis". It most often appears alongside 80,000 Hours, abundance liberalism, Afghanistan.

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September 04, 2025
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September 04, 2025
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Links For September 2025
September 04, 2025 · Original source
43: China think tank assessment of how in control Xi is: still very in control, maybe not infinitely in control. 44: Related - did you know (h/t xlr8harder) that if you ask AI to write a science fiction story, it will very often name the protagonist “Elara Voss” (or some very close variant like Elena Voss), and this remains true across various models and versions? Related: Chelsea Voss of OpenAI is having a baby and has the opportunity to do the funniest thing. 45: “Hector (cloud) is a cumulonimbus thundercloud cluster that forms regularly nearly every afternoon on the Tiwi Islands in the Northern Territory of Australia…[he is sometimes called] Hector the Convector”. 46: British allergy sufferers who want to know the ingredients of things demand that British cosmetics stop listing their ingredients in Latin. “For example, sweet almond oil is Prunus Amygdalus Dulcis, peanut oil is Arachis Hypogaea, and wheat germ extract is Triticum Vulgare.” 47: Text-based RPG about being an NYT journalist at the Manifest prediction market conference. I make a brief appearance. 48: Study uses supposedly-random variation in doctor assignments to test whether the marginal mental health commitment is good or bad for patients, finds that it is quite bad. Freddie de Boer is violently skeptical (maybe literally so?) and makes some good points about how a single quasi-experimental study is never absolute proof. But I don’t think he quite justifies his opinion that the paper was irresponsible and should never have been published; it’s just a normal quasi-experimental study that we should nod and say “huh” at but not overweight as the culmination of all possible research that overcomes all possible priors. My prior is that the marginal commitment is pretty useless (many commitments are just “well, since this person arrived at our ED for some reason, it would look bad from a medico-legal perspective to just let them go, so let’s keep them a few days to evaluate” - and yeah, you should be upset about this) but I’m still surprised by how many outright negative (as opposed to zero) effects the researchers found. The strongest argument for negative effects is that it will make some people miss work and maybe lose their job. But this study found that commitment ~doubles the risk of near-term suicide (admittedly only from 1% to 2%), which would have been outside my confidence intervals for how bad it could be. I suspect confounding, but only on general principle, and I wouldn’t be too surprised either way. 49: This tweet is probably bait, but I found it a thought-provoking question: I think there’s a boring answer, where the law is more complex than just a single number and whatever kind of weird trafficking Epstein was doing is worse than whatever normal relationships these European laws are permitting. But assuming that there’s a substantive difference even after taking that into account, I think my answer is something like - we’ve got to divide kids from adults at some age, there’s a range of reasonable possible ages, we shouldn’t be too mad at other societies that choose different dividing lines within that range - but having decided upon the age, we’ve got to stick with it and take it seriously (in the sense of penalizing/shaming people who break it). This is more culturally relativist than I expected to find myself being, so good job to Richard for highlighting the apparent paradox. 50: Dilan Esper describes his experience as one of Hulk Hogan’s attorneys in the Gawker lawsuit (X). Parts I found interesting: none of the lawyers knew Thiel was funding the lawsuit; Gawker probably could have won if they had been slightly competent but kept "shooting themselves in the foot"; and Gawker probably could have won if they had just pixelated the private parts in the video. 51: Amazing concept and poems (link on X): I tried to see if AI could do this, and it did something that technically met the requirements but had zero artistic merit - using a lot of words like “nowhere” and “outside” in one, then separating them out to “no where” and “out side” in the other. I didn’t invest much energy in creating a clever prompt telling it not to do that, so feel free to report if you get better success. 52: New study claims consultants are actually good, at least for profits: "We find positive effects on labor productivity of 3.6% over five years, driven by modest employment reductions alongside stable or growing revenue" 53: A Polish team tries to test Peter Turchin’s equations for predicting political unrest on recent Polish history, has to make some changes but claims mostly positive results. 54: New big multi-author Substack, The Argument, trying to be a sort of center-left version of the model pioneered by The Free Press and other high-production-value ideological Substack properties. Excited to see Kelsey Piper is involved, and she starts off strong with a post on the latest round of First World basic income studies, which find few positive effects. This is surprising, because recipients didn’t waste the money on alcohol or gambling or anything - they paid down debt and got useful goods. Still, it didn’t even affect things that should have been obvious, like stress level. It’s not even clear that amounts of money large enough to help with rent made homeless people more likely to get houses! Matt Bruenig criticizes the article, accusing Kelsey’s studies of being downstream of Perry Preschool style dreams that exactly the right welfare program will have massively compounding effects that cut poverty out at the root and turn everyone into elite human capital; he thinks giving people money won’t do this, but it will increase equality and give the poor better lives. I assume he’s not a strong hereditarian, but his argument makes even more sense from that perspective, and I’ve certainly criticized dumb outcome measures like infant brain waves which we have only tenuous reasons to think are related to anything we care about. But Kelsey reasonably responds that the outcome measures she’s talking about include stress level and life satisfaction. To defuse this critique, Bruenig either has to argue that our construct “life satisfaction” doesn’t really measure whether someone’s life is satisfactory, or else claim that giving poor people satisfactory lives isn’t really what we’re going for - which I think would require more explanation on his part. There’s some further (impressively acrimonious) debate on X, but I don’t see anything that addresses my core concern. GiveDirectly, a charity involved in basic income experiments, has a presponse here; they say that some studies are positive, and that the ones that aren’t might have tried too little cash to matter, or been confounded by COVID making everything worse. They also point out that basic income is harder to study than traditional programs like giving people housing, because if you’re giving housing you can measure housing-related outcomes directly and have a pretty good chance of getting enough statistical power to find them, but since everyone spends cash on different things, the positive effects might be scattered across many different outcomes (and therefore too small to reach significance on each). Everyone involved in this debate wants to emphasize that the poor results are for First World studies only, and that studies continue to show large benefits to giving cash in the developing world. 55: Related: I was less impressed by The Argument’s first foray into housing policy, which follows an all-too-familiar pattern: Some people say they don’t like noise and disorder and try to make rules against it in their apartments.
Inline links: China think tank assessment of how in control Xi is, xlr8harder, Chelsea Voss of OpenAI is having a baby, Hector (cloud), demand that British cosmetics stop listing their ingredients in Latin, Text-based RPG about being an NYT journalist at the Manifest prediction market conference, finds that it is quite bad, violently skeptical, literally so?, This tweet, https://substackcdn.com/image/fetch/$s_!S9fU!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fa558c09b-7fb6-40a8-a8a0-27b658a2c876_576x687.png, describes his experience as one of Hulk Hogan’s attorneys in the Gawker lawsuit (X), link on X, https://substackcdn.com/image/fetch/$s_!zyh7!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F75e9f0f6-d794-4ea2-b24b-5d4803bf28dc_590x478.png, New study claims consultants are actually good, tries to test Peter Turchin’s equations for predicting political unrest on recent Polish history, The Argument, a post on the latest round of First World basic income studies, criticizes the article, infant brain waves, debate on X, has a presponse here, first foray into housing policy
Prussian tradition1 mentions across 1 issues

Prussian tradition is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between May 07, 2025 and May 07, 2025. The archive places it in contexts such as "a demotic corruption of the old Prussian tradition". It most often appears alongside 2025-Yarvin, Antiversity, Apple.

Reference entry
Prussian tradition
Mention count
1
Issue count
1
First seen
May 07, 2025
Last seen
May 07, 2025
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Issue trail
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Moldbug Sold Out
May 07, 2025 · Original source
A patchwork of city-states, unbound by modern “international law”, with few barriers to the free flow of capital and population. I’ll then describe how carefully Moldbug explained that you had to have these things, or else the dictatorship would fail in more or less the ways normies expect dictatorships to fail - leaving himself no room for the kind of pivot he’s trying now. 1: Classic Moldbug Believed Populist Dictatorship Would End In Disaster Classic Moldbug admitted that fascism and communism were extremely bad. He just drew different borders around political systems: fascism, communism, third world banana republic dictatorship, and democracy all cluster together as systems where coalitions rule because they can seize temporary power in a semi-lawless society. In the various totalitarianisms, it’s literal seizing of power through armed troops or secret police; in democracy, it’s electoral seizing of power through distributing the most goodies to coalition members. From here, my bolding. Clearly, the worst forms of demotism, the really bad apes, were the totalitarian systems—fascism and communism. The main difference between fascism and communism was not in mechanism, but in origin—fascist elites tended to be militarist, communist elites intellectual. But the one-party state is a clear case of convergent evolution. To a neocameralist, totalitarianism is democracy in its full-blown, most malignant form. Democracy doesn’t always deteriorate into totalitarianism, and lighting up at the gas pump doesn’t always engulf you in a ball of fire. Many people with cancer live a long time or die of something else instead. This doesn’t mean you should smoke half of Virginia before lunch. A political party is a political party. It is a large group of people allied for the purpose of seizing and wielding power. If it does not choose to arm its followers, this is only because it finds unarmed followers more useful than armed ones. If it chooses less effective strategies out of moral compunction, it will be outcompeted by some less-principled party. When one party gains full control over the state, it gains a massive revenue stream that it can divert entirely to its supporters. The result is a classic informal management structure, whose workings should be clear to anyone who watched a few episodes of The Sopranos. Without a formal ownership structure, in which the entire profit of the whole enterprise is collected and distributed centrally, money and other goodies leak from every pore. Totalitarian states are gangster states, in other words, and they tend to corruption and mismanagement. The personality cult of dictatorship is quite misleading—a totalitarian dictator has little in common with a neocameralist CEO, or even a cameralist monarch. The difference is the management structure. The CEO and the monarch owe their positions to a law which all can obey, and those who choose to obey the law are naturally a winning coalition against those who choose to break it. The dictator’s position is the result of his primacy in a pyramid of criminals. This structure is naturally unstable. There is always some other gangster who wants your job. Dictators, like Mafia chiefs, are not good at dying in bed. The internal and external violence typical of totalitarian states is best explained, I think, by this built-in mismanagement. Dictators are violent because they have to be—they use violence as an organizing principle. The totalitarian state has no principle of legitimacy that would render it impractical for an ambitious subordinate to capture the state with a coup. European monarchs made war, sometimes they were assassinated, and there were even succession struggles, but coups in the modern sense were very rare. Note that the financial logic which keeps the neocameralist state lawful does not apply in any way to the totalitarian state, because the latter does not have a stable management structure which is controlled by its shareholders. Lawlessness is not profitable for the state as a whole, but it may be quite profitable for the part that chooses lawlessness, and in the totalitarian state no one is counting as a whole. Similarly, only shareholder control gives the neocameralist state an incentive to remain small and efficient. The totalitarian state has an incentive to become large and inefficient, because every functionary has an incentive to expand his or her own department, and no bean-counter who demands that the department do more with less. In a totalitarian state, since no gangster is permanently safe from any other gangster, there is a strong incentive for anyone with power to take what he can, while he can. And there is no disincentive for him to avoid abusing a resource which neither he nor his allies benefit from. Under gangster management, the totalitarian states often engaged not only in mass murder, but mass murder of their most economically productive citizens. I’m trying to avoid subjecting you to too many Moldbug walls of text, but this is a constant hobbyhorse of his. Unless you implement his neocameralist ideology of shareholder control, your attempted autocracy will become a totalitarian state, which will be even worse than regular democracy. 2: The Dictator Must Not Be Elected The original sin of democratic/totalitarian governments is permitting power struggles. When you permit power struggles, the most power-hungry person wins. This person is probably a bad guy. But even if he isn’t, he has to optimize for gaining and maintaining power, instead of for the national interest. This usually means paying off the people who raised him to and keep him in power, i.e. corruption. Sometimes the corruption is straightforward, like giving friendly colonels vast sums from the public treasury. Other times it’s more insidious; if someone rose to power because organized labor joined their coalition, they have to overpay public unions, pass stifling pro-labor regulations, and ban whatever productive economic activity the labor unions don’t like. Therefore, we need a dictator who came to power without a struggle and doesn’t owe anyone anything. This is Moldbug’s read on “the divine right of kings”: Divine-right monarchy is very easy to understand, even for an atheist like me. We have already derived it. To an atheist, the King’s authority must be absolute, not because he is appointed by God, but because he is appointed by no one. If someone appoints him, that man is King. If their roles are divided—the famous “balance of powers” or “checks and balances”—they will struggle, and one or the other prevail. Probably the many over the few. How do you come to power without a fight? This is a tough ask, but Classic Moldbug bit the bullet: anybody who wants power is unworthy of it. You have to just sit there being worthy. When people get tired of sucking, they’ll give you power. The Procedure [for installing a virtuous government] comes in Three Steps: 1: Become worthy. 2: Accept power. 3: Rule!!1! You think I’m kidding. But I’m not. How do you become worthy? You must absolutely, 100%, avoid any kind of candidacy in elections, protesting the government, criticizing the government, thinking you could do government better than the current government, or (god forbid) deliberately trying to take power: As a reactionary, you don’t believe that political power is a human right. You will never convince anyone to adopt the same attitude, without first adopting it yourself. Since you believe others should be willing to accept the rule of the New Structure, over which they wield no power, you must be the first to make the great refusal. They must submit to the New; you must submit to the Old. The reactionary’s opinion of USG is that it is what it is. It is run by the people who run it. And at present, the present management may well be the best people in the world to run USG, and even if they’re not he can’t imagine what might be done about it—short of replacing the whole thing. This simple and final judgment, like the death penalty, admits no possible compromise. In particular, passivism is to Gandhi as Gandhi is to Hitler. Hitler, before 1933, was a violent democratic activist; Gandhi was a nonviolent democratic activist. Passivism is not any sort of activism. Passivism is passivism. In plain English, you may not even begin to consider the rest of the Procedure until you have freed yourself entirely from the desire, built-in burden though it be of the two-legged ape, for power. Break the steel rule, change your name to “Darth,” don’t expect to keep your internship at the Jedi Council. As a matter of both principle and tactics, the passivist rejects any involvement with any activity whose goal is to influence, coerce, or resist the government, either directly or indirectly. He is revolted by the thought of setting public policy. He would rather drink his own piss, than shift public opinion. He finds elections—national, state or local—grimly hilarious. And if he needs to get from Richmond to Baltimore, he drives through West Virginia. The passivist has a term for democratic activism directed by the right against the left. That term is counter-activism. Passivism does not dispute the fact that counter-activism sometimes works. For instance, it worked for Hitler. (We’ll say more about Hitler.) However, it only works in very unusual circumstances (such as those of Hitler), and is extremely dangerous when it does work (e.g., the result may be Hitler). In case this isn’t crystal-clear, the steel rule precludes, in no particular order: demonstrations, press releases, suicide bombs, lawsuits, dirty bombs, Facebook campaigns, clean bombs, mimeographed leaflets, robbing banks, interning at nonprofits, assassination, “tea parties,” journalism, bribery, grantwriting, graffiti, crypto-anarchism, balaclavas, lynching, campaign contributions, revolutionary cells, new political parties, old political parties, flash mobs, botnets, sit-ins, direct mail, monkeywrenching, and any other activist technique, violent or harmless, legal or illegal, fashionable or despicable […] In the First Step, passivism is a no-brainer. Why should you be interested in influencing OUSG? You’re trying to replace the Structure, not join it. One clear sign that you’re doing this right and haven’t been corrupted by power is that people won’t write hit pieces about your blog. I swear I’m not making this up: [A] passivist blog will appear, at worst, harmless and extremely strange. There’s something going on here, Mr. Jones. But you don’t know what it is—do you, Mr. Jones? As an existential enemy of USG, the reactionary may well deserve some immune attention. But he won’t get it, and he is quite happy with that. True fact: the author of UR has received over 7 zillion very interesting emails, all of which deserve responses, often long, that most have not received (but will). Number of hostile communications received, in over two years of blogging: zero. One can ascribe this result to many hypotheses, not all flattering, but I put it down to passivism. If you break this rule and seek electoral power, you are punished with something terrible: right-wing populism, which is basically the same as Hitler and must be prevented at all costs. [The] third tactical benefit [of passivism is] Hitler prevention. To an orthodox reactionary, Hitler is basically the poster child for what happens if you break the steel rule. Fascism is reaction, but laced with cancerous tumors of democracy—“right-wing populism,” as people say these days. If it loses it loses; if it wins, the tumors grow. An improvement on Communism, but not much of one. Just about all of Hitler’s shtick, right down to the name of his party, was ripped off from the Left. Who introduced nationalism to the Continent of Europe? The Hapsburgs, or Garibaldi? Under this camouflage, which never convinced anyone with a college education, Nazism was never in any way leftist. Rather, it was a demotic corruption of the old Prussian tradition […] Since most people are neither historians nor philosophers, the fact that Hitler was on the extreme Right, and this Reaction is also on the extreme Right, raises some natural concerns. Again: the only way to face these concerns is to (a) provide a complete engineering explanation of Hitler, and (b) include an effective anti-Hitler device in our design. The reactionary’s basic answer to the Hitler Question is the Law of Sewage. (This is not my invention, but I don’t know where I got it. Heinlein, perhaps?) The Law is: if you put a drop of wine in a barrel of sewage, you get sewage. If you put a drop of sewage in a barrel of wine, you get sewage. You’ll find that this rule applies perfectly to many fields of human endeavor. Thus, Nazism contains a great deal of reactionary wisdom, because those who created it were quite familiar with the old Continental tradition of government. However, the Nazi movement originated as a democratic political party. Thus Nazism combined the venom of democracy with the experience and efficiency of Prussia, an understandably dangerous combination […] This is where passivism, by abjuring democracy, vaccinates itself against Hitler. True: at a higher level, the reactionary seeks to cause a transition in power, and thus in a sense seeks power itself. But he is not an activist, because he is not working for power. His actions do not excite the human political instinct, the love for forming coalitions and tearing hell out of the apes across the river. For one thing, said actions bear no resemblance to normal politics. For another, they cannot bring any actual power to the actors, even if they succeed. Which, however likely, must remain intuitively implausible—if not laughable. And thus the project of reaction does not attract those with a real taste for power, which if nothing else is very un-Nazi-like. In other words - the failure mode of neoreaction (good) is right-wing populism eg Nazism (bad). You’ll know you’ve fallen into the failure mode if your reactionary movement starts with a democratic political party, or if its members are feeling normal human political emotions. If you can’t have a normal democratic party, how do you complete steps two and three - accepting power and ruling? Moldbug’s answer is complicated and not very related to our topic, but he thinks you first create the Antiversity, a shadow university system laser-focused on always telling the truth. Then you bootstrap it into a shadow government, which doesn’t engage in violent revolution or political campaigning, but just sits there being right about things (I’m imagining for example a shadow FDA that produces better drug information than the real FDA, so people gradually come to trust the shadow FDA more even though its rulings have no legal effect). Then people gradually switch their allegiance from the real government to the shadow government, until finally the shadow government proposes a pseudo-candidate in an election whose sole platform is “switch power from the real government to the shadow government”. Once he wins, he revokes the Constitution, implements the shadow government charter, and resigns. Why do you have to use this weird process instead of taking power the normal way? Because if you take power the normal way, you will fall into the trap of right-wing populism and become like Hitler: You start to see the difference between this and the Nazis. For the Nazis, the equivalent of the Antiversity was… Hitler. Have you read Hitler? I have. (The Table Talk is the Hitler to read.) Frankly, Hitler reads a lot like me, if I lost 25 IQ points from drinking lead soda, and also had a nasty case of tertiary syphilis. I may have some of Hitler’s talents—I will be the first to admit it. But I have no intention of applying for his job. I would never be able to do it, anyway. I don’t think anyone could. 2.5: The Dictator Must Not Need Anyone’s Approval This is a trivial extension of the previous point - “If someone appoints [the King], that man is King”. If the people appoint the King, the people are King, and then you’re a demotic totalitarianism. How do you avoid dependence on other people’s approval? In a democracy, you need the approval of 51% of people to win the next election; in a traditional dictatorship, you need the approval of the secret police or military to keep crushing your opponents. The reason [an unquestioned autocracy with no dissent] is peaceful and free is that we’ve defined [the autocrat’s] primary right so that it works just like a secondary right, [ie his legal rights are completely enforced by real power/control.] Hitler, Stalin and Mao, on the other hand, had enemies. Stalin and Mao, especially, basically operated under the assumption that everyone in the world wanted to kill them and take their jobs. After a while this was quite the self-fulfilling prophecy. Terrorist government—as in the Reign of Terror, a usage that’s unfortunately lapsed—is a consequence not of absolute primary title, but of insecure primary title. It is best understood as a form of civil war. So a dictator who still has enemies risks being crazy and genocidal. We’ll never get a dictator with nobody who dislikes him, but can we get a dictator with effectively no enemies - ie one whose enemies have zero chance of seizing power and so who might as well not exist? Yarvin admits this is a tough problem, but suggests cryptographically-locked weapons: In a full CDCC government, the sovereign decision and command chain is secured from end to end by military-grade cryptography. All government weapons—not just nukes, but everything right down to small arms—are inoperable without code authorization. In any civil conflict, loyal units will find that their weapons work. Disloyal units will have to improvise. The result is predictable, as results should be. That is, all weapons need a key to fire (or have a key that can prevent them from firing). The dictator owns the key. He can selectively disable weapons of rebel forces, allowing even the tiniest remnant of loyalists to easily overpower them. There are probably some implementation difficulties here; the point is that it’s definitely not democracy, nor even some kind of two-bit dictatorship where the dictator depends on the continued goodwill of the army. Why go to these lengths? Because without them, the dictator needs to curry favor through various corrupt strategies that undermine the national interest. Of these, the most malignant - the one Moldbug holds his deepest vituperation for - is fake news. Democratic parties necessarily lie, because they are not infinitely correct about everything, but they need the public to think they are. In order to maintain the support of the masses, they will lie about the nature of their policies, the details of their policies, and especially the success of their policies. There are two kinds of government: those whose formula of legitimacy depends on popular consent, and those whose doesn’t. Following contemporary usage, we can classify these as authoritarian and democratic. An authoritarian state has no need to tell its subjects what to think, because it has no reason to care what they think. In a truly authoritarian government, the ruling authority relies on force, not popularity. It cares what its subjects do, not what they think. It may encourage a healthy, optimistic attitude and temperate lifestyle proclivities, but only because this is good for business. Therefore, any authoritarian state that needs an official religion must have something wrong with it. (Perhaps, for example, its military authority is not as absolute as it thinks.) A democratic state which tells its citizens what to think is a political solecism. Think about the motivation for democracy: it consigns the state to the collective responsibility of its citizens, because it feels this is an independent and well-anchored hook on which to hang the common good. Once the republic has an established church, this hook is no longer independent, and the (postulated) value-add of democracy is nullified. Without separation of church and state, it is easy for a democracy to indulge itself in arbitrarily irresponsible misgovernment, simply by telling its bishops to inform their congregations that black is white and white is black. Thus misdirected, they are easily persuaded to support counterproductive policies which they wrongly consider productive. Moldbug warns that this is especially characteristic of right-wing populism, which is why he [Moldbug] is relieved when right-wing populism loses: The entire political structure of the American populist tradition is set up to select for ignorance and stupidity, and select against organization and cohesion. Thus it is simultaneously undesirable and ineffective, and even those of us who like myself sympathize with it to a considerable degree are often slightly relieved to see it lose, as it always does. 3: The Dictator Must Be Limited By A Board Of Directors How do we know that the dictator won’t have terrible policies, or be sadistic, or rename every state to “Statey McStateFace” just for fun? Moldbug proposes running the dictatorship as a joint-stock corporation. This helps in two ways. First, the dictator will be checked by a board of directors, who can fire him if he goes crazy. Second, the board of directors (or the investors who elect them?) will be aligned because they have stock. The stock goes up if the nation does better. If the dictator tries to kill the Jews and the market thinks that’s bad for business, then the directors will fire and replace the CEO. What happens if the controllers disagree on what “responsible” government means? We are back to politics. Factions and interest groups form. Each has a different idea of how Steve should run California. A coalition of a majority can organize and threaten him: do this, do that, or it’s out with Steve and in with Marc. Logrolling allows the coalition to micromanage: more funding for the threatened Mojave alligator mouse! And so on. That classic failure mode, parliamentary government, reappears [...] Actually, there’s one way to do it. We can define responsibility in financial terms. If we think of California as a profitable corporation, a capital asset whose purpose is to maximize its production of cash, we have a definition of responsibility which is not only precise and unambiguous, but indeed quantitative...We have, of course, reinvented the joint-stock company. There is no need to argue over whether this design works. It does. How would the board of directors remove a dictator who didn’t want to be removed? If the country is running on the cryptographically-locked weapon system discussed earlier, the directors will have a higher-level key that can overrule the dictator’s key and make sure that factions loyal to the board have working weapons while those loyal to the dictator don’t. How would the system guard against the dictator arresting the directors and torturing the key out of them? Maybe the directors could live in foreign countries (remember, they aren’t motivated by patriotism - they just want their stock to go up). Or maybe some of this process can be done cryptographically, so that nobody knows how many shares people have, how they voted, or even who the directors are at any given time. If the dictator started poking around to try to figure this out, the directors could remove him. I bring this up partly because 2025-Yarvin has been pushing the corporations vs. democracies argument pretty hard recently. Corporations, he argues, are nimbler and better-run than democracies. A big part of their advantage is that the buck stops with an autocratic CEO instead of a limited President. Therefore, to improve upon democracy, give President Trump the limitless powers of a corporate CEO. [When people ask me why I think monarchies are better than democracies] I ask them to look around the room and basically point out everything in the room that was made by a monarchy. Because these things that we call companies are actually like monarchies. And then you’re looking around yourself and you see, for example, a laptop. And that laptop was made by Apple, which is a monarchy. Whereas if your MacBook Pro was made by the California Department of Computing, you can only imagine it […] I think that if you took any of the Fortune 500 CEOs, some of them are good, some of them are bad. But the overall quality, just pick one at random, and put him or her in charge of Washington, and I think you’d get something much, much better than what’s there […] One of the things about monarchy that’s been known for quite some time—and again, even in very, very anti-monarchial regimes and periods, an exception is made for this—is that a ship always has a captain. An airplane always has a captain. Basically, in any very safety-critical environment … you should have someone in charge. But even granting that corporations are better-governed than democracies, this comparison doesn’t work. Corporate and national governance are trying to solve different problems. Corporate governance asks “Given pre-existing rule of law and the certainty that all of our bylaws will be enforced by a greater power, how do we ensure competent administration?” National government asks “How do we generate rule of law out of nothing in a way that can prop itself up and defend against attacks?” What prevents Tim Apple from refusing to pay dividends to Apple investors and keeping all the profit for himself? Easy question, it’s the United States government, no problem here. What prevents Donald Trump from murdering America’s five richest billionaires and taking their stuff? The police? What about the thing where Trump is the police chief’s boss’s boss’s boss’? Awkward, but that’s why we have separation of powers, checks and balances, government-of-law-and-not-of-men, all that stuff. What prevents Donald Trump from calling in the military to arrest all the other separate powers that are supposed to check and balance him? Uh, more separation of power, different checks and balances, some sort of loyalty to the Constitution. When Yarvin points out that companies thrive without separation-of-powers, that’s because they never encounter the problem that separation of powers was intended to solve. Classic Moldbug understood this well, which was why he proposed a separate power capable of checking his dictator - the board of directors1 - and a mechanism for keeping the system stable against power grabs - the cryptographic weapons. But the regime he boosts today has nothing like this, so it’s facile to use the corporate comparison argument. 4: The Dictator Must Be Embedded Within A Patchwork Of Similar Corporate City-States. Architectonics already did a great job covering this one. Read his Part 1 and Part 2, then meet me back here for the Conclusion section. At Long Last, I’ve Created The Populist Strongman From My Classic Series Of 11,000 Blog Posts “Don’t Create The Populist Strongman” I enjoyed reading Unqualified Reservations, way back in 2013. I didn’t agree with it, but I thought some parts of it were good, and even the bad parts helped me think clearly about the nature of power. I hoped the neoreactionaries would take the good parts, ditch the rest, and build something useful out of it. I think some people, mostly outside the organized neoreactionary movement, did exactly that (subscribers-only post, sorry). Unfortunately, Yarvin went the opposite direction, jettisoning the good stuff in favor of the bad. All the warnings against populism, party politics, corrupt power-seeking officials, misinformation, and mobocracy have been filed away in favor of a Flanderized “maybe dictatorship is good”. One reason I respect Sam Altman is that back in 2016, when he founded an AI charity to bring a positive singularity to the world, he realized that it would later be extraordinarily tempting to turn it into a normal profit-focused company and get rich. So he tied himself to the mast by designing a nonprofit structure capable of thwarting all the machinations his future self could throw at it. A few years later, he gave into temptation, tried to turn it into a normal profit-focused company, and failed, because the structure he designed was really good. This was the best possible outcome, and one of many reasons I number him among the all-time greats. Moldbug deserves a similar level of respect. He clearly saw that the failure mode of his philosophy was that power-seeking people would use it to support right-wing populism. He included a fantastic number of tests to determine whether any given self-professed reactionary was the real deal or a false prophet, begging his readers to apply them carefully to anyone claiming the mantle of reaction. Then he got corrupted by power and tried to use his philosophy to endorse right-wing populism. But the tests are still there! Anyone who reads through 11,000 blog posts can see all the red flags where Moldbug says “…and if I ever do X, then I’ve sold out and you should stop listening to me.” Another all-time great! Just the few posts I’ve highlighted in this essay have listed over a dozen tests - by tests I mean something where Moldbug says something is an absolutely vital feature of the new regime, or that without it things would descend into kleptocracy, or that this is the only safeguard against Hitler, or something along those lines. These include: The reactionary party always tells the truth
Inline links: here, The Sopranos, Divine-right monarchy, through West Virginia, Mr. Jones, Moldbug’s answer, Reign of Terror, suggests cryptographically-locked weapons, they will lie, is relieved when right-wing populism loses, proposes running the dictatorship as a joint-stock corporation, has been pushing the corporations vs. democracies argument pretty hard recently, 1, Part 1, Part 2, did exactly that, and failed
Prussians1 mentions across 1 issues

Prussians is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between November 01, 2024 and November 01, 2024. The archive places it in contexts such as "it sounds like the Prussians are unhappy". It most often appears alongside /r/BadMTGCombos, @cremieuxrecuel, @justin_garson.

Reference entry
Prussians
Mention count
1
Issue count
1
First seen
November 01, 2024
Last seen
November 01, 2024
Outbound links
Issue trail
Related pages
Source context
Links For November 2024
November 01, 2024 · Original source
It’s the red line on this chart; if you can’t see a red line at your screen resolution, then you’ve learned something important about the the EU tech sector. 37: Seen on @cremieuxrecuel’s twitter (preliminary, needs replication): Jews may have gone from 65-29 Democrat/Republican in 2020 to 58-40 this election. 38: Extelligence has a post responding to my critique of the cultural Christianity argument (among, uh, many other things), but I don’t really think it connects. I’m not telling atheists they can’t go to church/synagogue if it makes them feel happy and fulfilled - I’ve done this myself sometimes. My post was meant to argue against the claim that, for pragmatic reasons, atheists should support the Christianization of society as a defense against Islam or postmodernism or some other philosophical enemy. 39: Related: Extelligence is finally going for their Trust Assembly project/idea/startup for online consensus-based truth-seeking (I think something like a cross between Community Notes and Wikipedia, but as a browser extension, and for everything). He’s looking for potential developers/testers/users. 40: Jiankui He is the Chinese geneticist who made history with the first germline gene editing in humans (resulting in three babies supposedly immune to AIDS, although nobody has tested this). China sentenced him to three years in prison for unauthorized experimentation, but now he’s out of jail, has an English-language Twitter account, has a new lab, wants to work on Alzheimers, and seems pretty based (although not infinitely based): 41: Anthropic has a new version of their AI Claude which can use your computer. You give it permission, put it on a virtual desktop, and ask it to do things for you (eg “please find and download a picture of a cat” or “please research these ten things and put them in a text file”.) It moves your cursor, browses the Internet, and creates and saves files. People keep saying they’ll care about AI “when it operates autonomously” or “when it becomes an agent”. But this is a trivial barrier, and one which Computer Use Claude has arguably already passed. So far this feature is limited to developers (though anyone with computer knowledge can sign up for it) but I expect it to be the near future of consumer AI, to get better quickly, and to shade gradually into the “autonomous” “agentic” AI that you all think will require a paradigm shift. 42: Claim (from the IDF): Hamas faked polls showing that most Palestinians supported the October 7 attack; the real numbers are 31% in favor, 64% against. 43: Otto von Bismarck wanted to trick France into declaring war on Germany. In order to provoke the French, he sent the Ems Dispatch, a statement describing recent diplomatic events in a way that sounded maximally offensive. The French were so offended that “crowds” in Paris demanded war, and the Franco-Prussian War was declared soon afterwards. The part of this that I find most interesting is the text of the dispatch itself, which read: After the news of the renunciation of the Prince von Hohenzollern had been communicated to the Imperial French government by the Royal Spanish government, the French Ambassador in Ems made a further demand on His Majesty the King that he should authorize him to telegraph to Paris that His Majesty the King undertook for all time never again to give his assent should the Hohenzollerns once more take up their candidature. His Majesty the King thereupon refused to receive the Ambassador again and had the latter informed by the Adjutant of the day that His Majesty had no further communication to make to the Ambassador. I’m fascinated by the idea that only 150 years ago, it was obvious that if someone sent you this statement, you had to declare war or abandon all honor. If I read it carefully, I can sort of parse out that it sounds like the Prussians are unhappy, but that’s the most emotion I gather from it. Anyway, the Franco-Prussian War led to World War I which led to World War II - so if you don’t like 50 million people dying and the total devastation of Europe, blame this statement about ambassadors. 44: The first use of artificial insemination in humans: The first recorded case of artificial insemination by donor didn’t occur until 1884, when Dr. William Pancoast decided to treat a couple’s infertility by secretly inseminating the woman with sperm obtained from a medical student. The insemination happened while the patient was under anesthesia and Dr. Pancoast did not tell her what had occurred. She gave birth to a baby boy nine months later, but it was several years before the doctor finally confessed to her husband what he had done. Neither man ever informed the mother. It was 25 years later the result of this case was published. Dr. Pancoast was roundly condemned for his actions, but it did open the door for consensual sperm donor insemination. 45: ClearerThinking administers several personality tests to the same people to learn more about their comparative accuracy. I am most interested in their finding that tests with “factors” (eg the Big Five, where you rate people on a numeric scale) are inherently more accurate than those with “types” (eg Myers-Briggs, where you assign someone a specific category) and that, adjusting for this, Big Five is no more predictive than the Enneagram: 46: In 2022, I wrote Whither Tartaria, where I asked why ornate classical styles switched to more austere modernist styles around 1900 - 1950 in a variety of different arts (painting, architecture, literature, poetry, etc). I proposed seven theories, but was unsure which if any were true. Since then, Samuel Hughes of Works In Progress has been investigating. In May, he wrote a well-researched article showing that it wasn’t just increasing cost, because ornate classical architecture now costs less than ever. Now in a new article he demolishes a different theory - it’s not just decreasing cost (and subsequent lack of ability to signal wealth) - because costs didn’t decrease in several other arts, and the change was led by artists with rich people as reluctant followers. He concludes: Modernism may well be a status game of some kind; it may well signal taste more than it signals wealth; and this latter feature may be one of the things that distinguishes it from older artistic styles. But the mechanism by which this change came about must be different to the one Alexander describes. 47: Sort of kind of related - When Hamilton Lost Its Snob Appeal. The musical Hamilton was briefly an artistic/cultural phenomenon, but tastemakers eventually switched to making fun of it. Why? Rob Henderson says it happened after ticket prices came down and the common people could enjoy it. I disagree: everyone I knew who was into Hamilton got into it from the free online soundtrack long before they’d seen the show; I think this is more likely the usual fad cycle where anybody who’s too into yesterday’s fad is behind the curve and therefore uncool. 48: Related: Why are people such jerks to public intellectuals? And more. I agree this is a great mystery. 49: Some prominent Substack psychiatrists doing a video Q&A, submit your questions here. 50: Naomi Kanakia: The Literacy Delusion had a number of explanations for why reading books seemed to be so much worse for human beings (in terms of emotional wellness and productivity) than other forms of narrative entertainment, but its main theory was the integration hypothesis. That the stream of words in a book trained the human brain into a habit of self-consciousness, that reading books forced human beings to think of themselves as a stream of text, processed through time, making a coherent argument of some sort. And that this overall flattening effect forced readers to ignore aspects of their personality or their situation that were not otherwise in line with the overarching story they'd created about themselves. Basically, reading books causes repression and neurosis. The Literacy Delusion argued that, yes, human beings are storytelling machines, but that a stream of written text is a particular kind of story—a story that is particularly flat, particularly devoid of conflicting or harmonizing information—and that this flatness creates a peculiar effect on the human brain. 51: Last month, I linked Sasha Gusev’s No, Intelligence Is Not Like Height and asked people who disagreed to share their arguments; they sure did. First, several people pointed me to a new preprint, Family-GWAS Reveals Effects Of Environment And Mating On Genetic Associations, which finds that one of the main papers Gusev cited to make his case, Howe 2022, made a mistake - imputing sibling genotypes using a process designed for non-sibling genotypes - and that once that mistake is corrected, the finding disappears and intelligence and height appear similar. Second, Joseph Bronski has a more specific post where he responds to Gusev’s points one by one. He accuses Gusev of “[making] up his own chart to remove the error bars [from the originals], to obscure the fact that the study found no evidence for this in IQ”, and says that the cases where he didn’t do that are just “population stratification and range restriction”. Third, Noah Carl at Aporia, instead of writing a direct response like Bronski, argues that the usual method of attacking twin studies is obsolete; not only have the most-debated assumptions behind twin studies been thoroughly validated, but there are now other lines of evidence besides twin studies which confirm high IQ heritability. Fourth, Leonardo Parro (not framed as a response to Gusev) goes into more depth about one of those ways, a “pedigree-based analysis” demonstrating heritability of 54 - 69%, ie no “missing heritability” compared to twin studies. He summarizes this as the effect of “rare variants” compared to the usual SNPs - ie if you only look at the most common genes that are easiest to find, you get “missing heritability” compared to twin studies, but if you widen your search to rare genes that are hard to find, you don’t. 52: Extremely related: Heliospect is a startup promising polygenic selection for IQ and other traits; they were trying to stay in stealth mode but The Guardian spied on them and nonconsensually revealed their existence. The discussion on the r/ssc subreddit centered on their claim that (given enough embryos to choose from) they could increase a baby’s expected IQ by 6 points (I’ve also heard 7.5). Sasha Gusev had previously argued that current technology maxed out at 3.5 and future technology would max out at 6, so a claim of 6 - 7.5 is pretty extreme; Gwern, who wrote the pioneering analysis of this technology, was also skeptical. But Heliospect says they’ve got better predictors than academia that use the rare variants everyone else misses; after talking to the company, Gwern retracted his objections and says he finds their claim “pretty plausible”. Local ACX commenter geneticist Gene Smith also redid some calculations, changed his mind, and says “probably pretty realistic”. I find this interesting not just because of the polygenic selection angle, but because if Heliospect is right then their predictor is able to predict more genetic IQ than the “missing heritability” people believe exists, and it should be able to put this argument to bed once and for all. 53: This month in censorship: X/Twitter banned journalist Ken Klippenstein for sharing the Trump campaign’s dossier on JD Vance. Twitter’s side of the story is that the dossier was probably originally stolen by Iranian agents and they don’t want to support that kind of thing by letting people signal-boost the illicitly obtained goods; you can read Klippenstein’s side here. He appears to be unbanned now.
Inline links: @cremieuxrecuel, responding to my critique of the cultural Christianity argument, My post, is finally going for, Trust Assembly, has an English-language Twitter account, has a new lab, wants to work on Alzheimers, and seems pretty based, not infinitely based, https://substackcdn.com/image/fetch/$s_!fY_K!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F6b3b61c8-6c48-4eb7-9608-426b738ab9c8_592x111.png, which can use your computer, Claim, Ems Dispatch, The first use of artificial insemination in humans, administers several personality tests to the same people, https://substackcdn.com/image/fetch/$s_!epEc!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F47c474c6-d68a-41e4-954e-d24cd00ec040_740x388.webp, Whither Tartaria, a well-researched article showing, in a new article he demolishes a different theory, When Hamilton Lost Its Snob Appeal, Why are people such jerks to public intellectuals?, more, Some prominent Substack psychiatrists doing a video Q&A, submit your questions here, Naomi Kanakia, No, Intelligence Is Not Like Height, Family-GWAS Reveals Effects Of Environment And Mating On Genetic Associations, Howe 2022, a more specific post where he responds to Gusev’s points one by one, argues that the usual method of attacking twin studies is obsolete, goes into more depth about one of those ways, The Guardian spied on them and nonconsensually revealed their existence, discussion, previously argued, the pioneering analysis of this technology, Gwern retracted his objections, says, polygenic selection, banned journalist Ken Klippenstein, you can read Klippenstein’s side here., appears to be unbanned now
PSEN11 mentions across 1 issues

PSEN1 is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between August 14, 2025 and August 14, 2025. The archive places it in contexts such as "mutations on PSEN1 and 2, the genes for the enzyme that processes amyloid precursor protein into amyloid". It most often appears alongside A. Bejanin, A. de Calignon, A. Elobeid.

Reference entry
PSEN1
Mention count
1
Issue count
1
First seen
August 14, 2025
Last seen
August 14, 2025
Outbound links
Issue trail
Related pages
Source context
In Defense Of The Amyloid Hypothesis
August 14, 2025 · Original source
[94] D. Scheuner et al., “Secreted amyloid β–protein similar to that in the senile plaques of Alzheimer’s disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer’s disease,” Nature Medicine, vol. 2, no. 8, pp. 864–870, Aug. 1996, doi: 10.1038/nm0896-864.
Inline links: 10.1038/nm0896-864
Anti-amyloid drugs (like Aduhelm) don't reverse the disease, and only slow progression a relatively small amount. Opponents call the amyloid hypothesis zombie science, propped up only by pharmaceutical companies hoping to sell off a few more anti-amyloid me-too drugs before it collapses. Meanwhile, mainstream scientists . . . continue to believe it without really offering any public defense. Scott was so surprised by the size of the gap between official and unofficial opinion that he asked if someone from the orthodox camp would speak out in its favor. I am David Schneider-Joseph, an engineer formerly with SpaceX and Google, now working in AI safety. Alzheimer’s isn’t my field, but I got very interested in it, spent six months studying the literature, and came away believing the amyloid hypothesis was basically completely solid. I thought I’d share that understanding with current skeptics. The ATN model The most plausible variant of the amyloid hypothesis is the A → T → N model: amyloid causes tau causes neurodegeneration. 1: Amyloid The common entrypoint, typically at least 15 years before clinically detectable symptoms [1], is accumulation of amyloid-β deposits (especially Aβ42, one of several variants). Amyloid-β is a peptide produced in healthy human beings and many other animals, probably for antimicrobial purposes [2, 3]. Factors which cause overproduction of amyloid also cause Alzheimer’s. Factors that cause decreased clearance of amyloid also cause Alzheimer’s. The clearest relationship is various genes which massively increase amyloid production (while doing nothing else); these genes are Alzheimer’s risk factors, with some of the rarer and more severe ones causing extreme versions of the disease that manifest at otherwise almost-never-seen ages. One of the clearest examples is Down syndrome, which is caused by three (rather than the usual two) copies of chromosome 21. People with Down syndrome are at much higher risk of Alzheimer’s than the general population: two-thirds will have the condition by age sixty, and 15% have it by age forty. APP, the gene for the amyloid precursor protein, is on chromosome 21. This means that people with Down syndrome will have an extra copy. This extra copy has been observed to lead to higher-than-normal amyloid levels. But there are many genes on chromosome 21; do we have additional evidence that it’s the amyloid one that’s involved? Yes. Dozens of other mutations on APP cause the same sort of extremely young and severe Alzheimer’s. So do mutations on PSEN1 and 2, the genes for the enzyme that processes amyloid precursor protein into amyloid. So do mutations on several other amyloid-related genes. [6, 91 - 96] Researchers call these autosomal-dominant Alzheimer’s, meaning Alzheimer’s cases that get inherited from a single parent in a simple fashion typical of single-gene disorders. They make up about 1% of all cases, and are our strongest evidence for the causal role of amyloid in the disorder. To my knowledge, there is no serious claim that these genes could be working through any pathway other than their shared role in the amyloid system. But these autosomal-dominant cases only make up about 1% of all Alzheimer’s patients. Might they be a different disease than the usual sporadic Alzheimer’s that strikes people without strong family histories at normal ages? Probably not: the presentation and trajectory of autosomal-dominant and sporadic Alzheimer’s cases are strikingly similar. Both show an initial appearance of amyloid pathology starting in intrinsic connectivity networks in both autosomal-dominant [14] and sporadic [15–18] types, cortical tau appearing first in the medial temporal lobe and with the exact same fold in both disease types [97] (despite human tauopathies having at least seven other possible characteristic folds [36]), that tau pathology worsening and spreading outside this region only once amyloid pathology reaches sufficient severity [65], neurodegeneration progressing closely in step with the tau pathology, and the same usual approximate trajectory of cognitive symptoms due to the sequence of affected regions. So it’s as if two bank robberies occurred hours apart, in the same town, and in a highly similar and idiosyncratic manner, and we can positively identify the culprit of one on security camera footage. It’s a good bet the culprit of the other is the same. Increased amyloid production → Alzheimer’s is an especially clear and simple pathway, but any other change in amyloid can also cause the disease. For example Overproduction or reduced clearance of amyloid due to impaired slow wave sleep. Aβ production is neuronal activity-dependent, and toxins (perhaps including Aβ) are cleared from the brain during sleep via the glymphatic system. Thus Aβ can accumulate if the brain is more active and/or has less opportunity for clearance. [7, 8, 9, 10, 11]
Inline links: Aduhelm, David Schneider-Joseph
PSEN21 mentions across 1 issues

PSEN2 is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between August 14, 2025 and August 14, 2025. The archive places it in contexts such as "mutations on PSEN1 and 2, the genes for the enzyme that processes amyloid precursor protein into amyloid". It most often appears alongside A. Bejanin, A. de Calignon, A. Elobeid.

Reference entry
PSEN2
Mention count
1
Issue count
1
First seen
August 14, 2025
Last seen
August 14, 2025
Outbound links
Issue trail
Related pages
Source context
In Defense Of The Amyloid Hypothesis
August 14, 2025 · Original source
Anti-amyloid drugs (like Aduhelm) don't reverse the disease, and only slow progression a relatively small amount. Opponents call the amyloid hypothesis zombie science, propped up only by pharmaceutical companies hoping to sell off a few more anti-amyloid me-too drugs before it collapses. Meanwhile, mainstream scientists . . . continue to believe it without really offering any public defense. Scott was so surprised by the size of the gap between official and unofficial opinion that he asked if someone from the orthodox camp would speak out in its favor. I am David Schneider-Joseph, an engineer formerly with SpaceX and Google, now working in AI safety. Alzheimer’s isn’t my field, but I got very interested in it, spent six months studying the literature, and came away believing the amyloid hypothesis was basically completely solid. I thought I’d share that understanding with current skeptics. The ATN model The most plausible variant of the amyloid hypothesis is the A → T → N model: amyloid causes tau causes neurodegeneration. 1: Amyloid The common entrypoint, typically at least 15 years before clinically detectable symptoms [1], is accumulation of amyloid-β deposits (especially Aβ42, one of several variants). Amyloid-β is a peptide produced in healthy human beings and many other animals, probably for antimicrobial purposes [2, 3]. Factors which cause overproduction of amyloid also cause Alzheimer’s. Factors that cause decreased clearance of amyloid also cause Alzheimer’s. The clearest relationship is various genes which massively increase amyloid production (while doing nothing else); these genes are Alzheimer’s risk factors, with some of the rarer and more severe ones causing extreme versions of the disease that manifest at otherwise almost-never-seen ages. One of the clearest examples is Down syndrome, which is caused by three (rather than the usual two) copies of chromosome 21. People with Down syndrome are at much higher risk of Alzheimer’s than the general population: two-thirds will have the condition by age sixty, and 15% have it by age forty. APP, the gene for the amyloid precursor protein, is on chromosome 21. This means that people with Down syndrome will have an extra copy. This extra copy has been observed to lead to higher-than-normal amyloid levels. But there are many genes on chromosome 21; do we have additional evidence that it’s the amyloid one that’s involved? Yes. Dozens of other mutations on APP cause the same sort of extremely young and severe Alzheimer’s. So do mutations on PSEN1 and 2, the genes for the enzyme that processes amyloid precursor protein into amyloid. So do mutations on several other amyloid-related genes. [6, 91 - 96] Researchers call these autosomal-dominant Alzheimer’s, meaning Alzheimer’s cases that get inherited from a single parent in a simple fashion typical of single-gene disorders. They make up about 1% of all cases, and are our strongest evidence for the causal role of amyloid in the disorder. To my knowledge, there is no serious claim that these genes could be working through any pathway other than their shared role in the amyloid system. But these autosomal-dominant cases only make up about 1% of all Alzheimer’s patients. Might they be a different disease than the usual sporadic Alzheimer’s that strikes people without strong family histories at normal ages? Probably not: the presentation and trajectory of autosomal-dominant and sporadic Alzheimer’s cases are strikingly similar. Both show an initial appearance of amyloid pathology starting in intrinsic connectivity networks in both autosomal-dominant [14] and sporadic [15–18] types, cortical tau appearing first in the medial temporal lobe and with the exact same fold in both disease types [97] (despite human tauopathies having at least seven other possible characteristic folds [36]), that tau pathology worsening and spreading outside this region only once amyloid pathology reaches sufficient severity [65], neurodegeneration progressing closely in step with the tau pathology, and the same usual approximate trajectory of cognitive symptoms due to the sequence of affected regions. So it’s as if two bank robberies occurred hours apart, in the same town, and in a highly similar and idiosyncratic manner, and we can positively identify the culprit of one on security camera footage. It’s a good bet the culprit of the other is the same. Increased amyloid production → Alzheimer’s is an especially clear and simple pathway, but any other change in amyloid can also cause the disease. For example Overproduction or reduced clearance of amyloid due to impaired slow wave sleep. Aβ production is neuronal activity-dependent, and toxins (perhaps including Aβ) are cleared from the brain during sleep via the glymphatic system. Thus Aβ can accumulate if the brain is more active and/or has less opportunity for clearance. [7, 8, 9, 10, 11]
Inline links: Aduhelm, David Schneider-Joseph
Pseudomonas aeruginosa1 mentions across 1 issues

Pseudomonas aeruginosa is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between June 18, 2025 and June 18, 2025. The archive places it in contexts such as "isolated 34 bacteriophages targeting Pseudomonas aeruginosa". It most often appears alongside 1DaySooner, Aatu Koskensilta, acanthamoeba keratitis.

Reference entry
Pseudomonas aeruginosa
Mention count
1
Issue count
1
First seen
June 18, 2025
Last seen
June 18, 2025
Outbound links
Issue trail
Related pages
Source context
ACX Grants 1-3 Year Updates
June 18, 2025 · Original source
Minnesota and Virginia also have legislation to enable cities to implement land value taxes. We are monitoring these efforts. There are a few other cities we are operating in. We have helped another organization prepare for a meeting in Tennessee by doing impact analysis of land value taxes in the city. We have presented to city officials in the City of South Bend who have expressed support for land value taxes. Finally, we are in conversation with a State Senator in Colorado who is a champion of land value taxes. Meanwhile, we have soft launched and developed the OpenAVMKit, which uses a unified schema to do assessment accuracy reports and automated valuation methods for any property tax data given. Valuation of land is the key binding constraint to successful implementation of land value taxes. We plan to be the leaders in this space with strong benchmarking capabilities and a repo that can enable the open-source community to make the best automated valuation methods. Along with these efforts, we have expanded the movement. We have posted to the Progress and Poverty Substack growing the subscriber base to around 5,000 subscribers. We have spoken to over 25 local advocates interested in working on land value taxes in their local communities. Yet, there is a long way to go. We need to start earning income through technical assistance contracts as our grant funding expires. We need to continue pushing for a state to implement, and we need to be prepared to tell the success story for when they do. 65: EN’s Work On Bacteriophage Therapy Our project is aimed at pioneering phage therapy in Nigeria, where limited resources/infrastructure have historically held back research in this field. Starting from the ground up, we are establishing the foundational systems needed to support a robust phage research ecosystem. So far, we’ve isolated 34 bacteriophages targeting Pseudomonas aeruginosa, an essential step toward building a comprehensive phage bank. This began with collecting a wide range of clinical Pseudomonas isolates, which we are now characterizing alongside the phages through genome sequencing and phenotypic assays including studies on phage stability across pH, temperature, and salinity ranges. Our long-term goal is to develop a phage-based hydrogel for treating diabetic wounds. On the regulatory front, we have secured approval from the Attorney General to register our nonprofit organization, the Centre for Phage Biology and Therapeutics. Additionally, we’re expanding into vaccine development; following a research stay in Prof. Roderick's lab at the University of Waterloo, we have initiated the design of a phage-based universal Salmonella vaccine aimed at covering all major serotypes—an urgent need underscored by Africa’s reliance on external vaccine sources during the COVID-19 pandemic. I have signed an MTA agreement with Roderick to use his phage-based vaccine platform patents to enable us to design vaccines against any common disease affecting us. This is only the beginning, but we are proud to be laying the scientific and institutional groundwork for homegrown phage innovation in Africa. Emergent Ventures funded EN before we did and deserves a lot of credit here also. 66: Create An Artificial Kidney For an implantable artificial kidney, the first essential component is a hemofilter designed to emulate the glomerulus. Critical requirements for this hemofilter include high permeability (to maximize flow for a given area), selectivity (specifically, the retention of albumin), and robust blood compatibility (ensuring sustained function over time). Our initial strategy focused on using negative surface charge to reduce fouling. I began by testing polyelectrolyte (PE) coatings on 24nm pore membranes featuring a negative terminal charge, similar to the glomerular barrier. These initial static tests, assessing platelet adsorption in whole blood, yielded positive outcomes for some polyelectrolytes, indicating potentially desirable blood compatibility. However, static test setups are not truly representative of dynamic in-vitro conditions and don't provide data on key parameters like permeability, fouling progression, or changes in membrane selectivity. To address these limitations, I designed and built a blood filtration setup. This system sustains human whole blood in circulation for 20 minutes, allowing us to analyze all the aforementioned parameters, as well as platelet activation markers. This has resulted in a fairly high-throughput system for evaluating any surface coating. I'm pleased to report this setup has been accepted for presentation at this year's European Society for Artificial Organs (ESAIO) conference. I am also currently working on a full manuscript, as I believe this system offers a viable way to partially replace animal experiments in our early-stage research, requiring only 1.2ml of human blood per run. Working with a PhD student (hired to support both this research and work on membrane substrates), we have continued testing these PE coatings, alongside PEG coatings, on our membranes. Here, we're finding that optimization of the coating layer is crucial. With the current PE coatings, we observe a permeability drop of about an order of magnitude compared to the base membrane, making them unsuitable for an implantable device in their present form. This is likely due to the specific nature of the initial PE layer, which we can modify. We also suspect there may be ingress of PE into the pores, meaning we're not achieving just a surface coating (our goal), but rather a very thick coating, which would explain the flux loss. Optimizing the coating process to control penetration depth is now a primary focus of my ongoing work. I am currently aiming for a flux of 20ul/min (as this is cap introduced by the protein gel layer anyway) but for it to be at this 'steady state' permeability without drop in permeability. I am also imaging the membranes after contact with SEM to see if there is indeed any platelet adsorption etc. Tugrul has the dubious honor of maybe being "the only person to climb a 4000m peak with severe kidney failure". To raise money and awareness for his artificial kidney project, he is running Climb Against Time, where he will climb 41 mountains over 4000m (13000 ft) this summer. He is looking for donors and climbing partners. 67: Add Tardigrade Genes To Human Cells The goal of this one was to make hybrid cells that are more resilient for research and certain medical applications. They report: The grant was to synthesize vectors for the expression of humanized tardigrade proteins that can be targeted to different areas of the cell. All the vectors were designed, generated, and transposed into human cells. The proteins all localize successfully (e.g. they match the designed target), with one exception (we are still working on validating it). We've done some stress testing with the trangenic cells, but haven't reached firm conclusions yet. We've further generated some multigene designs but have not yet transposed them into cells, but should shortly. We're hoping to submit a manuscript on the first round later this year. 68: Teach Forecasting To EU Policy-Makers The original project didn't work out, but our grantee (who still prefers to remain anonymous) is now working with an EU think tank pursuing the same agenda, and has been teaching forecasting workshops to policy-makers for the past two months. 69: Platform For Single-Cell Imaging They ended up unable to accept this grant and returned the money. 70: Open Source Polygenic Predictor For EA/IQ They have an update here. They think they have a predictor that can explain 12% of variance in intelligence, and they’re working on validating it and creating an easy-to-use website. 71: Improve Flu Vaccines The grant mainly funded agent based modelling to demonstrate the benefit of pre-existing immunity to pandemic influenza if and when a future pandemic occurs (academic publication will result). The original proposal was to attempt to influence the WHO influenza strain selection process. After attending WHO meetings and a global influenza conference, I believe this is not feasible. Stakeholder feedback was the potential short term negative effect on vaccine hesitancy is believed to outweigh the less tangible future benefit. Given the conservative nature of decision makers, pandemic vaccines are likely to remain research only. There are still green shoots of research into pandemic preparedness/prevention that I am continuing to work on. I'm working under the "Australians for Pandemic Prevention" brand of Good Ancestors, another group that ACX funded in 2024. 72: Scenario Analysis For Developing World Agricultural Programs In addition to the research and analysis funded by the grant, I’ve learned to code with LLMs and have built an MVP of the project. The app is being considered for further development by staff at a large international organization. 73: Further C’s Political Career C’s political career is going well, but he continues to think it wouldn’t be strategic to give more information publicly at this time. Lessons Learned I'm most impressed with our lobbying/advocacy organizations. In particular, Good Ancestors has gotten the Australian government to sign onto an international AI safety declaration, partner with various x-risk-related organizations, and (possibly) extend charity tax deductions to some EA causes that previously didn't have it - I think this on its own goes a substantial way to paying back the cost of all ACX Grants. Coalition to Modify NOTA has a kidney donation bill in front of Congress that the (very illiquid) prediction markets give a 45% chance of passing; if it works, it could save thousands of lives. The Georgists are partly responsible for bills making land value taxes slightly easier to implement in a handful of states. Good Science Project seems to have significantly improved science. Are lobbying organizations a better bet than other types of nonprofit (within the constraints of ACX Grants)? I'm not sure. It could just be that lobbyists are (naturally) better at playing themselves up and sounding successful than (for example) scientists, or that politicians are good at people-pleasing and make people feel heard and encouraged in a way that might not change overall policy later. Also, I recently talked to some grantmakers who funded a lobbying organization that superficially seems excellent, but they expressed concern it was net negative (!) by taking away oxygen and spotlight from potentially more effective orgs. So I am encouraged but wary. Animal welfare organizations were another standout success. Again, I don't know how to think about this - while I think our grantees were exceptional, there's also an issue where the scale of animal welfare challenges is so great, and work on them so neglected, that lots of organizations can save a million chickens here, or a million fish there, without particularly making a splash. On the one hand, this is exactly what effective altruism should be doing - exploring grants that are very high in linear utility even if they don't feel satisfying. On the other, they're unsatisfying - and also hard to assess retroactively. How many chickens should a good animal welfare grant save? Any realistic number will both be overwhelmingly large in absolute terms and far too small in relative terms. I'm most ambivalent about our science grants. Many of them say they are successful and can point to published papers which explain the science they did. But it's hard to judge whether anything useful has changed based on the science getting done. I know it's important to fund basic research and not just last-mile technology startups, but it's hard for a mini-grants program like this one to evaluate these kinds of abstract interventions. One disappointing result was that grants to legibly-credentialled people operating in high-status ways usually did better than betting on small scrappy startups (whether companies or nonprofits). For example, Innovate Animal Ag was in many ways overdetermined as a grantee - former Yale grad and Google engineer founder, profiled in NYT, already funded by Open Philanthropy - and they in fact did amazing work. On the other hand, there were a lot of promising ACX community members with interesting ideas who were going to turn them into startups any day now, but who ended up kind of floundering (although this also describes Manifold, one of our standout successes). One thing I still don't understand is that Innovate Animal Ag seemed to genuinely need more funding despite being legibly great and high status - does this screen off a theoretical objection that they don't provide ACX Grants with as much counterfactual impact? Am I really just mad that it would be boring to give too many grants to obviously-good things that even moron could spot as promising? Someone (I think it might be Paul Graham) once said that they were always surprised how quickly destined-to-be-successful startup founders responded to emails - sometimes within a single-digit number of minutes regardless of time of day. I used to think of this as mysterious - some sort of psychological trait? Working with these grants has made me think of it as just a straightforward fact of life: some people operate an order of magnitude faster than others. The Manifold team created something like five different novel institutions in the amount of time it's taken some other grantees to figure out a business plan; I particularly remember one time when I needed something, sent out a request to talk about it with two or three different teams, and the Manifold team had fully created the thing and were pestering me to launch a trial version before some of the other people had even gotten back to me. I take no pleasure in reporting this - I sometimes take a week or two to answer emails, and all of the predictions about my personality that this implies would be correct - but it's increasingly something that I look for and respect. A lot of the most successful grants succeeded quickly, or at least were quick to get on a promising track. Since everything takes ten times longer than people expect, only someone who moves ten times faster than people expect can get things done in a reasonable amount of time. In almost every case where I thought to myself “this is a cool idea, but I don’t know how it’s going to really pay off, as opposed to reaching a cool intermediate accomplishment and then stagnating”, this was a correct criticism, and I should have taken it more seriously. But I can’t rule out that these were good in vague and hard-to-measure ways that I should take more seriously. This one is really self-serving, but in general when people were good communicators (or even bloggers) and wowed me with the writing-composition of their application, they turned out to be a good bet. And when people were hard to understand and annoying to communicate with, even if their ideas seemed good, they were less likely to pan out. Overall Thoughts The total cost of ACX Grants, both rounds, was about $3 million. Do these outcomes represent a successful use of that amount of money? Very naively, startups originating from ACX Grants have about $50 million in value1. If ACX Grants is equivalent to a pre-seed funder, and pre-seed funders usually get ~5%, then if we were VCs we would have a portfolio worth $2.5 million. About 1/5 of ACX Grants were attempting to be market-valued startups, so if we assume the charitable portion did about as well as the startup portion, then the charity portion is “worth” $10 million. There’s some reason to expect this is too high, since much of the startup value came from one successful outlier. But there’s another reason to expect this is too low, since we were aiming at charity rather than market cap, and any actual market cap that our grantees got was an unexpected side effect. I’m treating this as a sanity check rather than as a real number. It’s harder to produce Inside View estimates, because so many of the projects either produce vague deliverables (eg a white paper that might guide future action) or intermediate results only (eg getting a government to pass AI safety regulations is good, but can’t be considered an end result unless those regulations prevent the AI apocalypse). Because we tend towards incubating charities and funding research (rather than last-mile causes like buying bednets), achieved measurable deliverables are thin on the ground. But here are things that ACX grantees have already accomplished: Improved the living/slaughter conditions of 30 million fish.
Inline links: Progress and Poverty Substack, Climb Against Time, here, 1
PSH1 mentions across 1 issues

PSH is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between June 23, 2022 and June 23, 2022. The archive places it in contexts such as "PSH [permanent supportive housing]". It most often appears alongside 1978, 2016 essay, A Resounding Success Or Disastrous Failure: Re-examining The Interpretation Of Evidence On The Portuguese Decriminalisation Of Illicit Drugs.

Reference entry
PSH
Mention count
1
Issue count
1
First seen
June 23, 2022
Last seen
June 23, 2022
Outbound links
Issue trail
Related pages
Source context
Book Review: San Fransicko
June 23, 2022 · Original source
“There is no substantial published evidence as yet to demonstrate that PSH [permanent supportive housing] improves health outcomes or reduces healthcare costs. The one exception is a randomized trial of Housing First that found improved health outcomes for patients with HIV/AIDS.”
…and find that: Those in the intervention group incurred 2.6 fewer hospitalized days (p = .08), 1.2 fewer emergency room visits (p = .04), 7.5 fewer days in residential substance abuse treatment (p = .004), 9.8 fewer nursing home days (p = .08), and 3.8 more outpatient visits each year (p = .01) annually compared with those in the usual care group. Those in the intervention group had 7.7 fewer prison days during the study period (p = .07). Those in the intervention group had 62 more days in stable housing (p = .001) and 12 more days in respite care (p = .002) than those in the usual care group. Those in the intervention group used case management services (i.e., telephone calls and face-to-face meetings) more frequently than those in the usual care group, having on average 18 more encounters per year (p < .001). This study provided case management along with the free housing. I don’t know whether to think of that as a confounder, or a standard aspect of Housing First programs (especially since it is much harder to case manage someone with no fixed address). Notice that it assumes the cost of housing is given as $30/day. I think this is realistic for low-income housing in Chicago, but other California programs I’ve looked at have worked out to more like $70 - $100/day, which (assuming nothing else changed) would switch the conclusion of this study from “Housing First saves money” to “Housing First costs money”. Now let’s see what San Fransicko has to say: The evidence for Housing First turns out to be significantly weaker than its proponents suggest. For example, the much lauded initiative to reduce homelessness among veterans was only four percentage points more successful than the overall decline in homelessness, when accounting for age, which is necessary to accurately estimate what is due to policy and what is due to demographic changes. As for Utah, its legislative auditor general concluded in 2018 that the 91 percent number was wrong, based on a sloppy use of incorrect methodologies. Before 2015, Utah had annualized its homeless count, meaning that researchers counted the homeless at a single point in time and multiplied the data by some factor. But after 2015 the state used raw point-in-time counts, causing a precipitous drop in the official population counts. Over the same period, the state also narrowed its definition of chronic homelessness in several ways, resulting in further apparent reductions. In reality, the homeless population in Utah increased by 12 percent between 2016 and 2020. An experiment with 249 homeless people in San Francisco between 1999 and 2002 found those enrolled in the city’s Housing First program, Direct Access to Housing, used medical services at the same rate as those who were not given housing through the program, suggesting that the Housing First program likely had minimal impact on the participants’ health. Wrote a team of researchers, “obtaining housing does not necessarily resolve other issues that may impede one’s housing success,” pointing to the lack of significant improvements in substance use and psychiatric symptoms over the twelve months that people were housed (the share of patients with severe substance use actually saw a modest increase). The problem with Housing First stems from the fact that it doesn’t require that people address their mental illness and substance abuse, which are often the underlying causes of homelessness. Several studies have found that people in Housing First–type housing showed no improvement in drug use from when they were first housed. In 2018, the National Academies of Sciences, Engineering, and Medicine published a review of the scientific literature of Housing First. “On the basis of currently available research,” the report’s authors wrote, with some surprise, “the committee found no substantial evidence that [permanent supportive housing] contributes to improved health outcomes, notwithstanding the intuitive logic that it should do so and limited data showing that it does do so for persons with HIV/AIDS.” Tsemberis said he was not surprised by the findings of the National Academies. “It’s not like housing creates improved health,” he said. “You have to have a relationship with a nurse. You have to be educated on what your health problems are. You have to have a team that engages you and makes you an active participant in your own health care. I don’t even know if that would stop the number of deaths.” And, at least in the study funded by Benioff and conducted by Margot Kushel, which had those services, it did not. All of this seems to fit with what I found above. But: Housing First may even increase addiction and overdose deaths and make quitting drugs more difficult. Warned a multiauthor review in 2009, “One potential risk [of Housing First’s harm reduction approach] would be worsening the addiction itself, as the federal collaborative initiative preliminary evaluation seemed to suggest.” The authors pointed to an experiment that had to be stopped and reorganized after the homeless individuals in the abstinence group complained of being housed with people in the control group, who didn’t stop their drug and alcohol use. “They claimed that they preferred to return to homelessness rather than live near drug users.” The multiauthor review cited is Housing First For Homeless People With Active Addiction: Are We Overreaching? They write: “It would be premature to conclude that Housing First programs cannot accommodate persons with severe addiction. But it also would be premature to suggest that research data provide clear guidance on whether, or how, Housing First programs can accommodate persons with ongoing severe drug and alcohol abuse. In the absence of research data on this subject, it is reasonable to consider the kinds of risks that may occur in Housing First programs. One potential risk would be worsening the addiction itself, as the federal collaborative initiative preliminary evaluation seemed to suggest (Mares, Greenberg, and Rosenheck 2007), or failing to progress toward addictive recovery.” Elsewhere, they describe this same study as: “The eleven-site federal collaborative initiative found an association between early access to housing and increases in alcohol problems during the subsequent year” The study is here, but I can’t find this result anywhere. It describes its own results (my emphasis) as: The average number of days housed in the previous 90 days increased dramatically from 18 at baseline, to 68 at the 3-month follow-up, and rose steadily thereafter to 83 at the 12 month follow-up (Table 2). Mean monthly public assistance income increased steadily from $316 at baseline to $478 one year later, a 50% increase. Significant improvements of modest magnitude were also observed in overall quality of life, mental health functioning, and reduced psychological distress. Alcohol and drug problems remained largely unchanged over time. Total quarterly health costs declined by 50%, from $6,832 at baseline to $3,376 at 12 months. A 54% decrease in mean inpatient costs ($5,776 to $2,677) accounted for nearly 90% of the overall decrease in quarterly health care costs during clients' first year in the program And the table (slightly edited for readability): I might be misunderstanding this - I can’t imagine why the authors of the review would have gotten this wrong - but it does look to me like alcoholism stayed steady throughout this study. A 24-month followup of what I think is the same study also finds that drug users who were housed used slightly fewer drugs over time, although probably not to any significant degree worth caring about: Continuing from San Fransicko: There is evidence that privacy and solitude created by Housing First make substance abuse worse. A study in Ottawa found that, while the Housing First group kept people in housing longer, the comparison group saw greater reductions in alcohol consumption and problematic drug use, and greater improvements to mental health, after two years. “One reason for the surprising results,” wrote the authors, “may be that aspects of the Housing First intervention, such as the privacy afforded by Housing First and harm reduction approach, might result in slower improvements around substance use and mental health.” Okay, but the next sentence after the one the book quoted was the researchers admitting that oops, we also totally forgot to randomize our groups in any way, so the experimental and control groups had totally different levels of severity and maybe that was why they found this weird thing (this is non-obvious, because we’re looking at change over time rather than raw differences between groups, but the authors discuss some reasons why different groups might change differently over time). A few years later these same researchers did a proper randomized study and it found no difference in drug use between the two groups. Somers, Moniruzzaman and Palepu found no difference in drug use between Housing First and other subjects. Padgett et al found the Housing First group actually did better, although they are another victim of the epidemic of randomization failures in this space. Kirst et al, no difference in drug use, but Housing First better with alcohol. Milby found that housing contigent on abstinence worked better than housing not contigent on abstinence, which Shellenberger could have used to support his thesis, but even Milby found that housing not contingent on abstinence worked better than no housing! To summarize: I can find seven studies on this topic, only one of them agrees with San Fransicko’s thesis, and the authors admit that it’s weak. I accuse San Fransicko of citing only that one and pretending all the others don’t exist. (actually, I accuse it of doing that plus citing a line from a review claiming another study found this, but as far as I can tell that study did not actually find it) This is extra annoying, because all the popular news articles on Housing First gush about how it definitely decreases substance use and everything else bad. Shellenberger could have made the excellent point that all of these progressive journalists were totally wrong! This would have been an interesting, important, and completely true act of virtuous data journalism! Instead he tries to hold up a lonely negative result as representative, and ends up just as wrong but in the opposite direction. Continuing in San Fransicko: Researchers have found ways to use housing to reduce addiction. Between 1990 and 2006, researchers in Birmingham, Alabama, conducted clinical trials of abstinence-contingent housing with 644 homeless people with crack cocaine addictions. Two-thirds of participants remained abstinent after six months, a very high rate of abstinence, compared to other treatment programs. Other studies found that around 40 percent of homeless in abstinence-contingent housing maintained their abstinence, housing, and jobs. In a randomized controlled trial, homeless people were given furnished apartments and allowed to keep them unless they failed a drug test, at which point they were sent to stay in a shelter. Sixty-five percent of participants completed the program. Three similar randomized controlled trials also found moderate to high rates of completion. And participants in abstinence-contingent housing had better housing and employment outcomes than participants assigned housing for whom abstinence was not required. All of this seems basically true. It turns out that over longer periods of time, Housing First may not even outperform contingency in terms of keeping people housed. In the spring of 2021, a team of Harvard medical experts published the results of a fourteen-year-long study of chronic homeless placed into permanent supportive housing in Boston. Most studies of permanent supportive housing, including the Kushel study conducted in Santa Clara, only study the newly housed homeless for a span of around two years. The study found that 86 percent of the homeless, who were referred based on length of time living on the streets, suffered from “trimorbidity”—a combination of medical illness, mental illness, and substance abuse. The authors found that after ten years, just 12 percent of the homeless remained housed. During the study period, 45 percent died. The authors concluded that, because the chronically homeless had such higher rates of physical and mental illness, “the supportive services, essential to the PSH model, may not have been sufficient to address the needs of this unsheltered population.” This study was done on an especially severe subgroup of homeless people. There was no control group, so Shellenberger shouldn’t claim we have any evidence about whether Housing First can “outperform contingency”. Shellenberger counts people who died as “unhoused” to get his 12% number; if he didn’t do this, the number would be 23%. Only 23% of people given housing retained after ten years sounds bad. But you could change this number to whatever number you wanted by changing the severity of the subgroup selected for the study. Select people who are even crazier and more disturbed than these people, and you can have 0% retained after ten years; select high-functioning people with no problems, and you can get 100% retained after ten years. (or maybe not - the study doesn’t say why people left the program. It mentions that one possible outcome is having to go to a nursing home because they had grown too sick or old to support themselves. I am not sure that “23% stay in this program” means “77% are back on the street and all their care has been a total failure”.) Conclusion: Housing First seems to work in getting people housing. It probably also helps people use fewer medical services, and it might or might not save money compared to not doing it (probably more likely when treating very severe cases, less likely in areas with high housing costs). It probably doesn’t affect people’s overall health or drug use status very much. San Fransicko is right to call out all the people promoting it beyond what the evidence supports, but then goes on to attack it beyond what the evidence supports. Interlude: Why Can’t We Just House All The Homeless? This is the question many of the California gubernatorial candidates asked. California has lots of money. There aren’t that many homeless people. Everyone is already committed to Housing First. So why don’t they have houses already? San Francisco has about 7,000 homeless people. The median SF apartment costs about $3,000 per month (presumably the government officials in charge would be trying to buy cheaper-than-median apartments for this project, but they seem bad at that, so let’s stick with median as a high-end estimate). So that’s $250 million/year to rent every homeless person an apartment. San Francisco has a $14 billion budget, although some of that is locked in nondiscretionary programs. So this effort would take about 2-3% of the city budget. Given how many people have both altruistic and selfish objections to the current level of SF homelessness, I can’t imagine that isn’t a better use of the money than whatever it’s being spent on now. So why hasn’t this happened? The closest thing I can find to the “rent apartments” plan is Governor Newsom’s “rent hotel rooms” plan, Project Roomkey. This was a short-term pandemic program. This article says it cost $4,000 per month, which seems reasonable - it provided residents with a hotel room, meals, security, and “custodial services” for just above a hundred dollars a day. So how come nobody has made it permanent or scaled it up? The homeless themselves don’t seem very positive on the project. They talk about “jail”-like conditions, including curfews and bans on visitors. I don’t know if this is the usual nanny-state-ism, or an attempt to reassure hotel owners / other residents / local communities that the influx of homeless people won’t cause them problems. If the latter, it hasn’t worked. From here: Jenna Abbott, executive director of the River District Business Association, said having a Roomkey motel in her neighborhood has been difficult. The site — which is in an area with large number of unhoused people — has drawn family and friends of Roomkey residents who haven’t been housed but “camp close to that hotel,” some with the goal of gaining a room, Abbott said. That’s led to more loitering, public drunkenness and trash outside the restaurants, gas stations and other businesses in the area, she added. And here’s another article about people objecting to local hotels accepting homeless people, which focuses on some combination of zoning, code, and public safety concerns. Everybody - the homeless, their advocates, various experts - interviewed in the article - agrees that the hotel rooms are kind of dehumanizing and much worse than having real housing. And this article suggests that government budgeters believe it’s not cost-effective compared to alternatives. Since the homeless don’t like it, and it’s expensive, almost everyone seems to agree it made sense as a short-term COVID measure only. The government’s preferred medium-term solution is single resident occupancy (SRO) hotels. These are big apartment/hotel-like structures where everyone has a small bedroom and then there are communal bathrooms and maybe kitchens. These used to be the archetypal living situation for poor Americans (Matt Yglesias talks about them as “boarding houses” here). But moral reformers banned them in the 1900s on the grounds that they were slums - I think this is the usual “surely the reason poor people live bad lives is because capitalists oppress them by selling them cheap low-quality goods, and if we just ban selling people cheap low-quality goods, everyone will have high-quality goods and poor people will live great lives!” argument. Somehow this failed to work and homelessness got worse over this period, but there are still some SRO hotels left, and the government got them and converted them to public housing for homeless people. Shellenberger does not have high opinions of these: The Tenderloin [district of San Francisco]’s single resident occupancy hotels . . . have for decades been dominated by a culture of heavy substance use and prostitution. “Of the people in supportive housing in San Francisco, 93 percent have a major mental illness that we can name,” said a housing policy maker. “That is very, very high. Eighty percent use cocaine, speed, or heroin every thirty days, or get drunk to the point of unconsciousness.” Tom Wolf, a former Salvation Army caseworker and a member of San Francisco’s Drug Dealing Taskforce, says the city’s supportive housing facilities are themselves a major market for illegal drugs. “Go down the street to the Camelot Hotel on Turk Street,” said Wolf. “Almost everyone that I’ve seen in those hotels are using. The last front desk guy that was working there got busted because he was selling crack. The actual guy that works in the single resident occupancy hotel is selling crack! It’s insane, man.” In any case, there are only so many of these still left. The government often announces plans to buy defunct regular hotels and convert them into these structures, which would indeed be a medium-term solution for housing the homeless, except that they usually get bogged down in fights about code. Politico discusses one of these attempts in New York City (h/t Marginal Revolution): “There are very few hotels that physically could be converted and comply with the requirements of today’s zoning and building code without substantial, expansive reconstruction, partial removal or demolition,” said James Colgate, a land use partner at Bryan Cave Leighton Paisner LLP who has advised clients on zoning issues including the conversions of hotels. “That would increase the costs greatly.” For example, a building’s elevators, doorways, or rooms may be slightly short of the size required for a residential structure. Residential buildings are also required to have a certain amount of rear-yard space that a hotel may not have. “You would literally have to be chopping off part of the building,” Rosen said. …The legislation dictates that each unit include a kitchen or kitchenette with a full-sized refrigerator, cooktop and sink — something Rosen said made utilizing the program “simply too expensive.” “This is the classic case of the perfect being the enemy of the possible,” said Mark Ginsberg, a partner at the firm Curtis + Ginsberg Architects, which has worked on hotel conversions. Some advocates who pushed the creation of the program say those provisions were necessary to ensure it didn’t generate substandard housing […] “We didn’t want a program that cut corners to make it more palatable to developers,” said Joseph Loonam, housing campaign coordinator for the progressive advocacy group VOCAL-NY. “We wanted a program that centered the needs of homeless New Yorkers, which is true high quality affordable housing where they can have full autonomy and dignity.” As Marginal Revolution pointed out, Loonam got what he wanted; the expensive, over-regulated program was unpalatable to developers, with only one company putting in an offer; for whatever reason, NYC refused to go with that one company, and no housing was produced. But fine, these are also terrible, and they’re only medium-term solutions anyway. What about building real, long-term apartments for homeless people? Shellenberger tells the story of Los Angeles’ Proposition HHH, which raised $1.2 billion to do exactly this. They hoped to build ~10,000 units for the homeless, at a projected price of $140,000 each; since LA had about 30,000 homeless people at the time, this would solve a third of the problem - a good start. (how do these numbers line up with my back-of-the-envelope calculation for SF above? I talked about renting rather than building, but usually annual rents = 1/20th or so of total prices, so I was estimating about $700,000 per person. This is probably partly because SF costs more than LA, and partly because I was imagining median apartments whereas LA is probably working on very cheap apartments) But in fact, five years later, LA has completed only 700 units, and the cost per unit has spiralled to $531,000 each. Nobody has a good explanation for what happened, with Shellenberger quoting one local service provider who said a lot of it was “bullshit costs”. Now might be a good time to re-read Considerations On Cost Disease. [Update: this might not be accurate - see this comment] This seems to be a general problem: everyone is committed to Housing First and to long-term good solutions rather than short- or medium- term mediocre ones. But that means building housing. And some combination of NIMBYism and over-regulation means building housing is somewhere between ruiniously expensive and impossible. Claim 4: Shelters Are Unpopular Among Progressive Activists And The Homeless Themselves San Francisco doesn’t have more homelessness than eg New York, but almost all the homeless in New York live in shelters and stay off the street. Why doesn’t that work here? Shellenberger: In the context of cities with permissive attitudes toward drugs, like San Francisco, many homeless people stay in [tent] encampments to use illegal substances more freely and easily than they can in the shelters. Many policy makers understand this. “I went out with a team twice to have conversations with people to get an understanding of what they’re dealing with,” said Mayor Breed in 2020. “It was absolutely insane. Most of the people did not take us up on the offer [of shelter and services].” Even people who would prefer to live in sober environments say they do not want to quit their addictions. “When we surveyed people in supportive housing in New York,” said University of Pennsylvania homelessness researcher Dennis Culhane, “almost everybody wanted their neighbors to be clean and sober but they didn’t want rules for themselves about being clean.” In 2016, after the city of San Francisco broke up a massive, 350-person homeless encampment, dozens of the homeless refused the city’s offers of help. Of the 150 people moved during a single month of homeless encampment cleanups in 2018, just eight people accepted the city’s offer of shelter. In 2004, just 131 people went into permanent supportive housing after 4,950 contacts made by then-mayor Newsom’s homeless outreach teams. An article by a former homeless person explains the problems with shelters beyond just “can’t use drugs”. Residents are crammed into a small space with 300 other homeless people. Lice and bedbugs are everywhere. Everybody catches every disease. Everybody has stories about getting raped or beaten up. Invasive moralizing about drugs somehow exists side by side with rampant drug use. Shelters are gender segregated, which means straight people can’t stay with their partner. Most shelters ban children and nobody has any idea what to do with them. Most shelters ban pets - a lot of homeless people have dogs for protection or companionship, and you can’t just store them somewhere while you’re sheltering. Although some lucky people can get 90-day beds, other people need to apply for beds on a day-by-day basis, which requires waiting in line several hours every day. Users talk about rampant cutting in line, denying cutting in line, false accusations of cutting in line, etc. Most shelters kick people out between 9-5, either to save on staffing costs or in the hopes that they’ll get a job. But many have strict curfews requiring people to be back by 5 PM sharp, which can make jobs impossible - if your boss doesn’t let you out until 5 and you have a half-hour commute, how do you get back to the shelter on time? Results of a survey at one of SF’s new Navigation Centers at why their clients refused to go to normal shelters. But even the homeless people who do want to go to shelters mostly can’t get in. This app gives the current status of San Francisco’s homeless shelter waitlist. If you applied today, there would be 900 people ahead of you in line for one of the city’s 1500 - 2500 shelter beds. The app says that the median wait time is 826 days. So however many homeless people don’t want to go to shelters, we’re not building enough shelters to serve the ones who do. Why not? Shellenberger again: In the spring of 2021, Friedenbach published an op-ed opposing a proposal considered by the San Francisco Board of Supervisors to create, within eighteen months, sufficient homeless shelters and outdoor “Safe Sleeping Sites” for all of the city’s unsheltered homeless. “One can simply take a look to New York City,” she wrote. “Their department spends about $1.3 billion dollars of its budget on providing shelter for their unhoused population while thousands remain on the street. . . . As a result, New York has a higher rate of homelessness than San Francisco.” Housing First advocate Margot Kushel of the University of California, San Francisco agreed. “The problem with New York—and I spend a lot of time with people working in the system in New York—is that they spend an estimated $30,000 for each person per year to keep them in shelter. That’s not what we want to do. Because if you create the shelter and you don’t create the housing, then people are just in shelter forever.” Housing First advocates oppose shelter in Los Angeles. “Why haven’t we solved homelessness?” asked Housing First creator Sam Tsemberis. “Because [Los Angeles mayor] Eric Garcetti [has] Andy Bales [saying,] ‘You need emergency housing.’ ‘These people need to be cleaned up.’ ‘They need to be sober.’ ‘They need Jesus before they’ll be ready for housing.’ I said, ‘People should be housed and then maybe they’ll get sobriety and Jesus and the rest.’ We’re definitely on polar opposites of the whole thing.” Advocates for the homeless at the national level similarly oppose more shelters. “I don’t agree that we should be building more transitional housing,” said the head of the National Alliance to End Homelessness. […] In other words, the reason that there are so many homeless people on the streets in San Francisco is that both progressive and moderate Democratic elected officials, and the city’s most influential homelessness experts and advocates, have for two decades opposed building sufficient shelters. And that is unlikely to change even after San Francisco starts spending hundreds of millions more per year on the problem and might even get worse. This basically seems true. I found this webpage of a former SF Supervisor candidate a helpful corroborating source. He was running on a platform of “maybe we should build some homeless shelters”. He lost. You can also find a bunch of webpages by the sorts of people Shellenberger is complaining about, for example this site: Sup[ervisor] Rafael Mandelman today pushed his new legislation that would require the city to offer at least temporary shelter to everyone living on the streets, a step that some say would lead to more homeless sweeps and do nothing to create permanently affordable housing . . . [our] Coalition has argued for years that the solution to homelessness is housing—not temporary shelter, which may never lead to housing. The ex-supervisor candidate gives some helpful numbers: permanent housing costs about $600,000 per person housed. Shelters cost between $20,000 and $30,000 per person housed. So SF could build enough shelters to clear its waitlist for about $30 million. More recently, SF has tried a sort of compromise, opening “deluxe” shelters called Navigation Centers which avoid some of the problems of regular shelters. They also cost more than twice as much, and the city has only created about 300 beds. Also, the people in regular shelters are angry, because being in a regular shelter disqualifies you from getting into a (much better) Navigation Center. Some of them are considering leaving their shelter, going back on the streets, then waiting however many months or years it takes to get a Navigation Center bed instead. I’m not at all sure of these numbers, but it looks like of SF’s ~7,000 homeless, about 2,000 are in shelters already, and 1,000 are on the shelter waitlist. I don’t know if the remaining 4,000 have made a specific commitment not to go to shelters, or just have given up on the waitlist process. My conclusion: agree with San Fransicko about the role of progressive activists, but I think it overemphasizes the role of wanting to use drugs in why homeless people themselves sometimes avoid shelters, and underemphasizes the many other problems with them. Claim 5: Drug Decriminalization Isn’t Working California legalized marijuana in 2016. Shellenberger says that San Francisco’s commitment to drugs has gone beyond that: it has effectively decriminalized opioids, cocaine, and the rest. Any attempt to lessen use of these drugs is attacked as “stigmatizing”; instead, government policy centers around providing addicts with needles and other drug paraphernalia under the guise of “harm reduction”. Shellenberger hits all the right beats here. Like many people, he tries to undo the damage done by The New Jim Crow, a book which convinced millions of people that mass incarceration was driven by a racist War On Drugs. In fact, less than a fifth of prisoners are in for drug-related crimes. And when the government was first debating the War on Drugs and mass incarceration, black leaders were among the strongest proponents of both. The talking point at the time - among everyone from black Congressional leaders to black churches - was that the government’s failure to crack down on drug use was racist, borne of them not caring about predominantly black drug victims. And while we’ve been patting ourselves on the back about how enlightened we are for ending the drug war: Drug overdoses are today the number one cause of accidental death in the United States as a result of America’s historic addiction and overdose epidemic. Overdose deaths rose from 17,415 in 2000 to 93,330 in 2020, a 536 percent increase.Significantly more people die of drug overdoses today than of homicide (13,927 in 2019) or car accidents (36,096 in 2019). […] There are about twenty-five thousand injection drug users in San Francisco, a number 50 percent larger than the number of students enrolled in the city’s fifteen public high schools. San Francisco gives away more needles to drug users, six million per year, than New York City, despite having one-tenth the population. The part of this chapter that stood out to me as most worth looking into deeper was the section on Portugal: For decades, harm reduction and decriminalization advocates have pointed to Portugal as a model, noting that it decriminalized drugs and expanded drug treatment. In 2013, Portugal’s drug-induced death rate was sixty-six times less than that of the United States. The number of people in treatment increased by 60 percent between 1998 and 2011, with three-quarters receiving an opioid substitute like methadone or Suboxone, the brand name of buprenorphine. Drug use among 15- to 24-year-olds actually declined after decriminalization. “All drugs have been legalized,” explained Monique Tula, executive director of the Harm Reduction Coalition. “Their focus is on giving people tools, like job apprenticeships, and the means to support themselves.” […] [But Portugal] never legalized drugs. It only decriminalized them, reducing criminal penalties but maintaining prohibition. Drug dealers were still sent to prison even after the 2001 decriminalization. And Portugal does not let people addicted to hard drugs with behavioral disorders off the hook like progressive West Coast cities have done. It’s true that Portugal massively expanded drug treatment, but people are still arrested and fined for possession of heroin, meth, and other hard drugs. And drug users are typically sent to a regionally administered “Commissions for the Dissuasion of Drug Addiction,” composed of a social worker, lawyer, and doctor who encourage, push, and coerce drug treatment. And decriminalization doesn’t end drug violence. “Even if trafficking enforcement decreased, like it did in Portugal,” said criminologist John Pfaff, “illegal drug markets would still be forced to rely on violence to resolve disputes.” Indeed, prostitution and violence are ever-present in the open-air drug scenes in San Francisco, Los Angeles, and Seattle. “We are seeing behaviors from our guests that I’ve never seen in thirty-three years,” said Rev. Andy Bales, who runs the largest homeless shelter on Skid Row in Los Angeles. “They are so bizarre and different that I don’t even feel right describing the behaviors. It’s extreme violence of an extreme sexual nature.” People are not dying from drug overdose deaths in San Francisco because they’re being arrested. They’re dying because they aren’t being arrested. Decriminalization reduces prices by lowering production and distribution costs, which increases use. This was also the case for alcohol consumption. It increased after prohibition ended in the United States. Even in Portugal, drug overdose deaths and overall drug use rose after decriminalization. I was most surprised by the claim that Portuguese overdose deaths rose after decriminalization. Uncharacteristically, San Fransicko doesn’t give a citation for it, but we can try to retrace its reasoning. Decriminalization proponents tend to point to these numbers, helpfully converted to per 100,000 population and graphed here: But an anti-drug Australian think tank argues that the peak in 2001 is made up: Claims that there were more than 75 drug-related deaths in 2001 which more than halved to 34 deaths in 2002 use a figure for 2001 for which there is no substantiation. Official drug-related deaths for Portugal, taken from the latest 2018 EMCDDA Statistical Bulletin are copied below. Notice that there is no such figure recorded for 2001. They include a link to EMCDDA, the EU organization charged with monitoring these things. The link contains two datasets, both of which seem to be measuring the same thing but getting different results. One dataset starts in 2002, the other in 2008. I don’t know what the difference here is, but they’re right that neither includes 2001. If you ignore the pre-2002 data, the graph looks like this: They say “opiate”, but AFAICT these numbers are actually about all drugs. But the proponents link to the updated 2020 version of the same website, which all of a sudden does have data from 2001 and before. I don’t know why EMCDDA can’t make up its mind, but I think the Australians are wrong and the original graph is fine. On the other hand, does it really matter? Both of these show drug deaths decreasing until 2005, then going up and down a bit, then going back up again starting in 2011. I think a reasonable interpretation would be that decriminalization in Portugal did decrease overdose deaths a bit, and then they started rising again from that low baseline around the same time other European countries saw rising overdose deaths. I would also accept “these are pretty small effects and we shouldn’t ascribe any significance to them”. But San Fransicko’s claim - that overdose deaths increased after the reform - seems false. The only way I can see justifying it is taking the second graph - the one that wrongly claims there is no pre-2002 data - and then attributing the fact that twelve years after the reform lowered deaths, deaths finally rose above the pre-reform level to be the fault of the reform. This is like saying “people claim the Black Plague killed a lot of Europeans, but the European population actually rose after the Plague”, which is true in the sense that it was above its pre-Plague max by like 1600 or whatever. What about overall drug use? Here I recommend A Resounding Success Or Disastrous Failure: Re-examining The Interpretation Of Evidence On The Portuguese Decriminalisation Of Illicit Drugs, which is on exactly this topic of how people keep selectively quoting results from Portugal to prove their point. It argues that drug use is inherently hard to measure. There are four different Portuguese datasets for the time at issue, lots of different drugs, lots of different age/gender combinations, and lots of different ways of measuring drugs (did you use drugs in the past month? the past year? your lifetime?) It’s easy to tell a story of how past-month cocaine use skyrocketed among 14-29 year old males according to X source, or how lifetime marijuana use fell in high school-age women according to Y. The main trick that opponents use is measuring lifetime drug use. Portugal is a very conservative country; drug use is pretty new and most of the older generation wasn’t involved. So as time goes on and more and more people try drugs but “un-trying” drugs isn’t a thing, the percent of the population who have tried drugs inevitably goes up. This definitely happened but isn’t a fair reflection of any specific reform. The authors find that in the past decade or so, there has been a bit more short-term experimentation with drugs, but less long-run use. They conclude: As shown in Figure 2, general population (aged 15–64) trends for recent and current drug use in Portugal indicate minimal if any changes between 2001 and 2007. Instead, rates of discontinuation of drug use (the proportion of the population that reported ever having used a drug but opting not to in recent years) increased, which reinforces that just as in the school populations, the growth in lifetime-reported use reflected predominantly short-term experimental use. Increases in recent and current drug use were more notable in some cohorts, particularly those aged 25 to 34 (albeit, with a maximum of 7% of any one cohort reporting recent use, absolute levels remained low). But as shown in Figure 3, recent and current drug use declined among those aged 15–24, the population who were most at risk of initiation and long-term engagement. The available evidence thus gives grounds for arguing that while there was some growth in the scale of drug use in post-reform Portugal, there was an overall positive net benefit for the Portuguese community. What about San Fransicko’s main point - that as the US has wound down the War on Drugs, drug overdose rates have sextupled? I think this is mostly not causal. I think the sextupling of overdoses is a combination of expansion in prescription opioid use, various forms of social decay making people less happy and therefore more likely to use drugs, and “improvements” in drug “technology” and the “supply chain” (eg production of fentanyl in China). I don’t know of any source that attempts to tease out the exact contribution of all of these things, but I would note that overdose deaths have risen the most in very conservative Midwestern states that haven’t walked back the drug war as much as California. Conclusion: As usual, I appreciate San Fransicko’s corrections to the prevailing narrative, but its own additions are dubious. Its claim that Portugal saw increased drug-related deaths seems false as far as I can tell. Its claim that it saw increased drug use depends on your definition, but is misleading and not the most natural way to sum up the evidence. Claim 6: San Francisco’s Soft-On-Crime Policies Led To Rising Crime Ten years ago, the news was full of stories about how some teenager stole a gumdrop and was sentenced to nine hundred billion years in jail. At some point, there was a genre shift to stories about how some hardened criminal murdered fifty people with an axe and the judge let him go with a warning because having jails felt racist. Source: Ed West, do note that this example is from the UK How suspicious should we be of each type of story? There will always be an extreme right tail of overly harsh sentences, and an extreme left tail of overly lenient ones. Were the 2000s really as draconian as they felt? Is the modern era really as pathetic? Or is it all just a function of who you read and what agenda they’re pushing? Shellenberger: During California governor Jerry Brown’s time in office, voters passed several reforms aimed at reducing the size of the prison population. In 2012, voters passed a change to the Three Strikes law so that the third strike imposes a life sentence only if the new felony was serious or violent. In addition to lowering punishments for drug possession, Proposition 47, which voters passed in 2014, redefined shoplifting, forgery, petty theft, and receiving stolen property as misdemeanors when the value in question does not exceed $950. In 2016, voters approved a proposition that shortened the time it took for some nonviolent offenders to be eligible for parole and which released nonviolent offenders into drug treatment and rehabilitation. Property crimes rose in San Francisco starting in 2012. Larceny, which is shoplifting and other petty theft, rose 50 percent, from roughly 3,000 incidents per 100,000 people in 2011 to about 4,500 in 2019. Property crimes as a whole, which include larceny, motor vehicle theft, and burglary, rose from 4,000 incidents per 100,000 people in 2011 to 5,500 in 2019. One study suggests that Proposition 47 increased the rate of auto theft 17 percent and the rate of larceny (non-auto property) theft 9 percent, but discerning between causation and correlation may not be possible. Upon taking office in January 2020, [famously soft-on-crime San Francisco district attorney Chesa] Boudin followed through on his campaign promises. Instead of prosecuting and incarcerating people for breaking car windows to steal money and other items from inside, Boudin proposed creating a $1.5 million fund to reimburse car owners. But there were over 25,000 car break-ins reported in 2019. If every break-in cost just $250 in repairs, the fund would need four times that amount. And what would prevent people from falsely claiming to have been robbed in order to get city money? […] Boudin opposed efforts by the mayor and the city attorney to prevent drug dealers who had already been arrested from entering the Tenderloin. “Until the city is serious about treating addiction and the root causes of drug use and selling,” said Boudin in a statement, “these recycled, punishment-focused approaches are unlikely to succeed at doing anything more than making headlines.” Home burglaries rose in early 2021 in San Francisco. Homeowners started posting on Twitter videos from their security cameras of people breaking into homes and garages. “When I first moved here we had a car break-in problem,” said Michael Solana, a writer who works for a venture capital fund. “Now we have a home invasion problem. These things are wearing on people.” Boudin attributed the rise of burglaries in San Francisco to the decline of tourism and “people in desperate economic circumstances.” Progressive supervisor Hillary Ronen agreed. “We know that [economic insecurity and inequality] is one of the root causes of property crimes specifically,” she said. But Tom Wolf and others argued that the robberies were, like the shoplifting, done by people seeking money to buy drugs and feed their addictions. “The drugstores have been shoplifted to death and that’s all because of drug use,” said Tom. “I know. I used to do the same thing when I was out there. That’s what you do. You ‘boost.’ And then you go and you sell your stuff down at UN Plaza,” an open-air drug scene. In a May 2021 city supervisors’ meeting, a representative from CVS called San Francisco “the epicenter of organized retail crime in the country” and claimed that 85 percent of the shoplifting is committed by organized theft rings. Police broke up one such ring in October 2020 and recovered $8 million of stolen merchandise. The problem goes beyond property crime. Boudin declined to prosecute two men who went on to kill people. One man had been repeatedly arrested for stealing cars, despite having just been released from prison earlier in the year, and appeared to be abusing meth. On New Year’s Eve, 2020, the man killed two people while driving intoxicated. Police found inside of his car a semiautomatic handgun and twenty-three grams of methamphetamine. On February 4, another intoxicated driver killed a pedestrian in a stolen car. The San Francisco police had arrested him in October 2020 for possessing a stolen car, a tool for stealing cars, and what appeared to be meth. Boudin chose not to pursue charges. In December, the California Highway Patrol arrested the man again for driving a stolen vehicle under the influence. Again he was not prosecuted. The accident victim, an immigrant from Kenya, and his wife had moved to San Francisco two weeks before the fatal crash. “I blame the DA,” said the widow of the victim. The suspect, she said, “was someone who was out in the public who shouldn’t have been in the public. It was completely avoidable.” Tom said he could feel the difference on the streets. “Drug dealing is unabated and it’s not one guy, it’s fifty guys dealing fentanyl and meth,” he said. “And it’s going unabated because the district attorney says, ‘These are the nonviolent, quality-of-life crimes,’ and ‘I’m not going to prosecute them.’” [..] District Attorney Boudin was offering weaker sentences than even defense attorneys were requesting, according to Vicki Westbrook of San Francisco. “There’s a defense attorney who said, ‘It used to be that I would argue for this deal in court with the DA but now I don’t say anything because the DA is going to offer me a deal better than what I would have suggested. Somebody shot up the street with an automatic weapon. The first offer was six months in jail or time served plus two years of probation or something. And then [the DA] said, “How about thirty days in jail?”’” Vicki laughed. “You really can do anything in San Francisco,” she said. “If you do get arrested, chances are you’re going to be out of jail in less than thirty days for damn near everything except maybe killing somebody and maybe even then, too. It’s hard to say at this point.” Taking each of these points individually: Proposition 47 There are two good big studies on the effects of Prop 47, one by Public Policy Institute and one by some UCI criminologists. The PPI study finds that the proposition increased theft and car break-ins by about 10%. The UCI study finds the same, but notes that under different assumptions the effects wouldn’t quite obtain statistical significance. This seems a bit too much like post hoc trying to get rid of an inconvenient effect, plus an effect on the border of statistical significance is different from positively finding no effect. I think a reasonable interpretation is that theft and car break-ins rose about 10% because of the proposition, just as Shellenberger says. Some pro-47 sites note that most states have some limit on how much you to have to shoplift before it’s a felony, and Prop 47 brought California closer to the national average, rather than turning it into an outlier. Chesa Boudin Chesa Boudin took office two months before the COVID pandemic began. Any attempt to separate the effect of Chesa Boudin from the effect of the pandemic is doomed. Shoplifting definitely plummeted when Boudin took office, but that’s because all the stores were closed. Murders definitely rose a little after Boudin took office, but that’s because that was also when the Black Lives Matter protests happened, which demoralized police and led to a so-far-permanent spike in murders nationwide. Percent of criminals caught definitely fell when Boudin took office, but that’s because various aspects of the justice system were closed for COVID (I will grudgingly entertain speculation that a further decrease in arrest rates from 2020 to 2021 may have been a genuine Boudin effect). In the absence of any real way to judge his performance, I think San Fransicko’s points about Boudin are plausible, though speculative. Shoplifting This one is terrible. There’s a surprisingly spirited debate here (some of you may have already read Applied Divinity Studies’ article). The debate is: everyone on the ground in San Francisco - store owners, security guards, customers, random citizens - say that shoplifting has increased massively over the past decade. But statistics mostly say it hasn’t. Source here. This is shoplifting crimes per 100,000 people. Kern County is a deep red county in California (including Bakersfield) that is known for being tough on crime. Against this, seriously, everyone says that shoplifting has obviously increased. I had a patient who worked in shoplifting prevention, he told me - his psychiatrist! Who he had no reason to lie to! - that he was constantly stressed dealing with the shoplifting surge devastating the stores he covered. Here’s the San Francisco subreddit’s response to someone posting the data showing shoplifting hasn’t risen - it’s just a lot of people laughing hysterically. What’s going on? I was able to find a different set of statistics that does seem to show a longer-term increase in shoplifting (source): The very big spike at the end might be a change in reporting by one or two stores - you can find the argument here. But it does look like shoplifting went from about 125 incidents/month in the early 2010s to more like 250/month just before the pandemic. Why is this graph so different from the other one? It looks like the top one came from the Department of Justice, and the bottom one came from SFPD. I’m not sure why these report differently. When you multiply out by 800K people in SF, by 12 months/year, and 30ish days/month, the first graph corresponds to 4 shoplifting incidents per day, and the second to 6. As LouB’s analysis here points out, that seems suspiciously low for a city of 800,000 people where stores are constantly closing because of shoplifting. Maybe off by a factor of a few hundred from what we’d expect. LouB writes: The SFPD report only references shoplifting offenses that required SFPD officers to prepare an incident report. That means either the shoplifter fought security, committed additional crimes, or stole more than $950 worth of items. It’s not that SFPD’s report is erroneous, it’s just not a representative statistic. In a parallel statistic, SFPD only completes incident reports for traffic accidents when there is an injury. Therefore, thousands of noninjury accidents are handled civilly without SFPD reports the same way thousands of shoplifting offenses are handled without reports. An insurance company would not determine premium rates based solely on SFPD incident reports, nor should readers interpret SFPD shoplifting reports as anywhere near the total picture of the shoplifting epidemic in San Francisco. (this would also explain why one or two stores changing their reporting policy can produce a spike equal to everyone else in San Francisco combined) But comparing incident reports from 2010 to incident reports from 2020 should still be apples-to-apples, unless the likelihood of reporting any given incident changed in the meantime. Did it? This news article quotes a San Franciscan who says that when they try to report shoplifting incidents, the cops tell them not to because “it doesn’t make a difference”. If cops say that now more often than they used to, it would make all these statistics meaningless. (Applied Divinity Studies claims to have an argument that shows this can’t be true. It goes something like: if San Francisco was a better place to shoplift than its neighbors - eg Oakland - then shoplifters would leave Oakland to go to San Francisco, and we would see Oakland shoplifting rates falling. Oakland shoplifting rates are falling, but no more so than the rest of the state, so there can’t be increased tolerance for shoplifting in San Francisco. I find this dubious for many reasons. First of all, many of the same reasons shoplifting is up in San Francisco - like Prop 47 or soft-on-crime progressive policies - also apply to Oakland. Second, given that shoplifting fell massively everywhere because of the pandemic, it feels dubious to try to compare different cities; maybe one city had stricter pandemic lockdowns than others. Third, do criminals really shop around for friendly jurisdictions? If so, why are so many crimes like car break-ins, concentrated in “the bad part of town”? Why wouldn’t criminals leave the bad part of town for under-exploited areas with richer residents and less competition? Maybe criminals in fact aren’t very strategic or mobile? Maybe they don’t want to stand in the BART station and then take a half-hour train ride holding a bag of stolen goods?) Maybe a better argument against this being true is how stable the shoplifting rates have been over time. Wouldn’t it be weird if (let’s say) a tripling of the real shoplifting rates was matched by a third-ing of the reporting rates (rather than a halving or a quartering or whatever)? On the other hand, here’s Shellenberger with some helpful data: Some of this is probably because of Proposition 47, which made some forms of shoplifting punishable with citation rather than arrest (but wouldn’t that be a clear discontinuity rather than a gradual trend?) But overall it sure seems like shoplifting is being taken less seriously, which might encourage people to report less. Another statistic I see is that only 2.3% of shoplifting cases result in an arrest; I don’t know how this is different from the graph above with numbers in the 30s; maybe it involves different levels of what makes something a “case”. I accept that the data don’t consistently show a spike in shoplifting. But what’s the alternative? My patient who works in loss prevention in SF stores is lying to me? The nice elderly Chinese man who sold me my last pair of glasses and chatted to me about the rampant shoplifting in his mall was lying? The San Francisco police are lying? Walgreens pretends to be concerned about shoplifting as part of a dastardly plot to close a bunch of stores for no reason? Target and CVS pretend to care about shoplifting as part of a plot to restrict their stores’ opening hours for no reason? Every big store near me has suddenly gotten a security guard at the front as part of some corporate-sponsored jobs program? Maybe the conservative narrative that soft-on-crime San Francisco must be experiencing rising crime rates took on a life of its own. Maybe it infiltrated not just the usual suspects like the SF police unions, but even such supposedly-liberal bastions as the New York Times. Maybe lots of big corporations took advantage of the fake narrative to make unpopular business decisions they were planning on making anyway. And maybe ordinary San Franciscans, confronted with everyone telling them they were in a shoplifting epidemic, started paying more attention to security guards and petty criminals who had always been there, a sort of mass hallucination that gripped everyone in the city. I can’t rule this out. Americans thought crime was rising all throughout the early 2000s, when it was in fact way down. Or maybe some statistics that we already know are off by several orders of magnitude got off by an additional factor of two or so. I think this one is more likely, but I’m genuinely not sure. Other Crime From the Economist: The Center on Juvenile And Criminal Justice puts it even more starkly, arguing that “San Francisco’s ‘Crime Wave’ Is Just One Crime”: This are potentially susceptible to the same reporting bias as shoplifting. So what about homicide? Homicide is practically always reported and investigated, making it a gold standard in crime measurement. (source) Looks pretty good until 2019. I don’t expect to gain useful information post-2020; the pandemic and the post-George-Floyd murder surge will make it impossible to evaluate for local variation. What about compared to other places? For some reason this top 20 table fails to list Washington DC, which should be just before Atlanta. SF doesn’t make the top 20, although its neighbor Oakland does. Probably most murder variation in US cities is explained by percent African-American and maybe percent Borderer; with relatively few people in these groups SF was never in the running. I’m not sure if some abstracted version of the city with all demographic factors adjusted away would have an unusually high murder rate, but at that point it would be pretty distant from any interesting real-world question. You can see the leaderboard for other types of crime here; San Francisco is often in the top ten, but never the top three. As far as I can tell, San Francisco has seen a big spike in car breakins over the past few years, with no clear trend for other property crime, violent crime, or homicides. It’s not an outlier among American cities in any kind of crime. Conclusion of this section: San Fransicko’s specific claims are basically correct, but suggest a medium-term rise in SF crime which is mostly contradicted by the data. These show stable-to-decreasing murder, stable-to-decreasing violent and property crimes other than car break-ins, and large rises in car break-ins only. The data also show stable-to-decreasing shoplifting, but I’m not sure how much to trust them vs. common sense. Honestly, I’m pretty confused here and not sure what to think. Claim 7: Jim Jones (Of Kool-Aid Cult Fame) Used To Be The Chairman Of SF’s Housing Authority Okay, this isn’t really a statistical claim that I can research different perspectives on. Still, it’s so wacky that I couldn’t resist mentioning it in this review. Jim Jones, famous for killing everyone in his Guyana-based Jonestown cult with poisoned Kool-Aid, used to be the SF government’s top guy on homelessness. Shellenberger writes: Jones married and moved first to Northern California and then to San Francisco with his wife to start a church. He called it the People’s Temple. Jones believed he was the leader of a socialist revolution. He warned of nuclear war and claimed black people would be put in concentration camps. He became a hugely charismatic preacher among African Americans, the disaffiliated poor, and young transplants to the city looking for community. Scenes from the era show a remarkably large and diverse congregation smiling and singing. The People’s Temple grew and provided services. Jones cultivated two progressive San Francisco politicians, George Moscone and Willie Brown, and mobilized people to volunteer for their campaigns […] His son and a San Francisco historian believe he stole the mayoral election for Moscone in 1975. Historian David Talbot, founder of the progressive website Salon, points to evidence that Jones committed sufficient voter fraud to account for Moscone’s narrow 4,443-vote margin of victory. “We loaded up all thirteen of our buses with maybe seventy people on each bus, and we had those buses rolling nonstop up and down the coast into San Francisco the day before the election,” said Jones Jr. “Could we have been the force that tipped the election to Moscone? Absolutely! Slam dunk. He only won by four thousand votes.” When federal investigators looked into fraud claims three years later, they discovered that all of the records were missing from the city of San Francisco’s registrar of voters. Jones also boasted of providing Moscone with black women from his congregation for sex. One time Moscone, drunk and “accompanied by a young black woman whom the politician had kindly agreed to drive home,” crashed into another car. Another time, Moscone and Willie Brown “were with a black woman in an alley at two in the morning at some restaurant in North Beach,” said a local bar owner. State legislator “John Burton was part of that gang too. They were all using marijuana and cocaine.” Said Jones Jr., Moscone would “always be there at temple parties with a cocktail in his hand and doing some ass grabbing.” A Temple member overheard Jones speaking to Moscone the day after one of those parties saying, “I want to let you know that the young lady you went off with is underage,” adding, “Now don’t worry, Mayor, we’ll take care of you—because we know that you’ll take care of us.” Afterward, Moscone made Jones the chairman of the powerful San Francisco Housing Commission. Jones cultivated progressives with money and favors. He made large donations to the ACLU, the NAACP, and United Farm Workers. Jones and Moscone met privately with vice presidential candidate Walter Mondale on a campaign plane a few days before the 1976 presidential election, and Mondale praised People’s Temple shortly afterward. Jones met with First Lady Rosalynn Carter several times. Governor Jerry Brown praised Jones. Glide Memorial Church’s Rev. Cecil Williams loved Jones. There is a photo from 1977 of a smiling Williams awarding Jones the church’s “Martin Luther King, Jr. Award.” Jones used his perch as chairman of the Housing Commission to fight for housing for the poor. He tried to use eminent domain to acquire the International Hotel, a single resident occupancy hotel. After a court sided with the hotel’s owner, Jones mobilized seven thousand protesters to picket it. By mid-January 1977, the situation had become heated. There were rumors that protesters inside the building were armed with guns and Molotov cocktails. Jones lost the legal battle in 1977, and the tenants were evicted. But the drama was a publicity victory for Jones, which burnished his image as a white savior. A conservative member of the Board of Supervisors who was defeated in the mayoral election by Moscone accused the new mayor, the San Francisco Chronicle, and the rest of the city establishment of being blind to Jones’s extremism. “There’s no radical plot in San Francisco,” insisted Moscone, in response. “There’s no one I’ve appointed to any city position whom I regard as radical or extremist.” Willie Brown, a powerful state legislator from 1964 to 1995 before becoming mayor in 1996, “seemed oblivious to Jones’ hucksterism and demagoguery,” notes a historian. Brown was master of ceremonies at a dinner for Jones in the fall of 1976 attended by an adulatory crowd of the rich and powerful, including Governor Jerry Brown. “Let me present to you a combination of Martin King, Angela Davis, Albert Einstein . . . Chairman Mao,” he said, to loud applause. And yet Jones was contemptuous of Brown even as Brown did Jones more and more favors. Jones mocked Brown for his designer suits, sports cars, and women. Once, while Brown was addressing the congregation and Jones was seated onstage behind him, Jones flipped his middle finger up to mock him. San Francisco’s establishment stood by Jones even after a California magazine, New West, owned by Rupert Murdoch, published an exposé of Jones’s beatings of Temple members and financial abuses in August 1977. The article was written by a San Francisco Chronicle reporter and was meant for the Chronicle to publish. But the newspaper killed the story because it didn’t want to alienate Jones, whom it viewed as central to its plans to expand the Chronicle’s circulation in the heavily African American Fillmore District. Jones also managed to avoid investigation and prosecution in part by getting the district attorney to hire as deputy district attorney Jones’s longtime attorney and confidant. Progressives defended Jones against the New West article. At a rally in the summer of 1977, Willie Brown said, “When somebody like Jim Jones comes on the scene, that absolutely scares the hell out of most everybody occupying positions of power in the system.” Angela Davis sent a radio message broadcast over the cult’s compound, Jonestown, in Guyana. “I know you’re in a very difficult situation right now,” she said, “and there is a very profound conspiracy designed to destroy the contributions which you have made to the struggle.” After visiting Jonestown, the attorney to the Black Panthers said, “I have seen paradise.” Harvey Milk, too, was tarnished by his association with Jones. In the fall of 1977, Milk wrote to President Carter’s secretary of health, education, and welfare requesting that Social Security checks be sent to elderly Temple members in Guyana. “People’s Temple,” wrote Milk, has “established a beautiful retirement community in Guyana.” In truth, the cult was disintegrating. Jones separated families and lovers, pitted relatives against each other, and forced neighbors to inform on each other. Jones sent people who violated the rules to solitary confinement in “the Box,” an underground cubicle where people were held as prisoners for days on end. Others were drugged. Progressives who had spent thirty years fighting to close prisons and mental hospitals found themselves praising a man who had reproduced their worst practices. In November 1978 a Bay Area congressman flew to Guyana to investigate human rights violations at Jonestown with NBC News. Jones gave the delegation a formal reception at Jonestown. A Temple member surreptitiously passed a note to one of the delegation members, saying he and another member wanted to escape. They fled the next day after a Temple member tried to stab the congressman. Jones didn’t prevent them from leaving but then sent gunmen to fire machine guns at the delegation at the airport, killing the congressman and four others. A few hours later, 907 inhabitants of Jonestown drank Flavor Aid laced with cyanide and died. Two-thirds of the victims were African American and one-third were children. Jones had told them that if they didn’t drink it they would be killed by invading soldiers from a shadowy global military conspiracy intent on imposing fascism and torturing children. As people started crying in grief, Jones scolded them. “Stop these hysterics,” he said. “This is not the way for people who are socialists or communists to die.” Jones’s wife protested the murder of children and had to be forcibly restrained. “We didn’t commit suicide,” said Jones in a tape recording, “we committed an act of revolutionary suicide protesting the conditions of an inhumane world.” Few were as stained by Jonestown as Willie Brown and George Moscone. “Even as the bloated bodies of the dead were removed from the jungle and the wounded were airlifted by the U.S. Air Force to hospitals in the United States,” wrote a historian, “Brown said he had ‘no regrets’ over his association with Jones.” They repeatedly disavowed responsibility. Said Moscone, “it’s clear that if there was a sinister plan, then we were taken in. But I’m not taking any responsibility. It’s not mine to shoulder.” This is Shellenberger at his best: telling us crazy stories from the recesses of San Francisco history, maybe kind of spinning the narration in a way that makes all progressives seem guilty by association, but with the tale itself so gripping that it’s hard to be mad. And Jones wasn’t alone. This was the golden age of San Francisco cults, when (Shellenberger tells us) “more than half of all high school students in the San Francisco Bay Area reported at least one recruiting attempt by a cult member, and 40 percent reported at least three contacts.” This chapter of SF history came to an end in 1978, when Dan White, who had just resigned from San Francisco’s Board Of Supervisors (ie City Council) entered City Hall through a window and assassinated Mayor Moscone and fellow Supervisor Harvey Milk, then successfully got charges reduced to manslaughter through a legal manuever that has gone down in history as “the Twinkie Defense” (realistically the defense was that he was depressed, but reporters seized on a comment that implied it was because he ate too many Twinkies). Everything about 1970s San Francisco was like this. With the Mayor and his right-hand-man both dead, San Francisco leadership ended up in the hands of previously second-tier politician Dianne Feinstein. Feinstein was what passed for a moderate in 1970s SF (which meant she had been targeted for assassination by various left-wing groups - she survived when a bomb left on her windowsill failed to explode). In Shellenberger’s telling, she managed to clean up some of the mess and restore a semblance of normalcy. San Francisco never forgave her. Moscone - voting fraud committer, underage sex enjoyer, and Jim Jones’ bff - is beloved as a martyr in today’s SF, but (the book points out) Feinstein is so loathed that in 2021 the Board of Education voted to rename Dianne Feinstein Elementary School. The Moscone Center is 2 million square feet and can fit about 10,000 people. Not to be confused with the Moscone Recreation Center, Moscone Station, or Moscone Elementary School. Meanwhile, all Dianne Feinstein got was one lousy elementary school and the Tithonus package of eternal life without eternal youth. Claim 8: The Intolerant Left Shuts Down Debate On These Issues Another one that’s probably hard to do a randomized controlled trial on. You could probably predict that this one was coming - it’s a necessary narrative beat in this genre of book. I think this beat is good. My impression is that people who aren’t themselves public figures disagreeing with left-wing ideas still don’t understand how scary it is and how much hate you get. Maybe now that 2/3s of every political essay written over the past five years is about this topic, people will finally get it through their thick skulls that it exists and is bad. I would also note that “traumatizing the sorts of people who write popular books about politics, in a such a way that they feel compelled as a sort of self-therapy to write page after page telling readers how angry they should be at you and your whole coalition” isn’t great political praxis. I would like people to figure this out and stop doing it. Anyway, Shellenberger is doing his part in this effort: In 2001, the San Francisco Coalition on Homelessness wheat-pasted posters of a fake front-page San Francisco Chronicle across town. Just beneath the masthead a large headline read “Fuck the Homeless!” right above a picture of San Francisco mayor Willie Brown laughing. Below his photo was the headline “Save the Tourists.” Progressives level the same charges at people thirty years later. “Because of some of the stuff I say,” said a community activist in Seattle’s historically black Capitol Hill neighborhood, “people say, ‘Oh, she’s not for them.’ But I have a heart for homeless and mentally ill. Most of my family works with the mentally ill.” Noted a Chronicle journalist in 2017, “Inevitably, homeless advocates and others will say, ‘You’re not compassionate,’” in response to stories about homeless encampments. “They called me a racist,” said Tom. “They accused me, a guy who used to be homeless, of demonizing the homeless, because I’m asking for accountability.” I found myself similarly accused. In 2019, after I published an article for Forbes about the homeless crisis, a progressive homeless activist accused me on Twitter of having written my article to “make money off of a fear tactic” of “fueling hatred [and] even increasing violence against homeless people.” After I asked the former San Francisco supervisor for the Tenderloin neighborhood, former mayoral candidate Jane Kim, how such a progressive city ended up with so much suffering, she said, “My concern, Michael, just to be very honest, is that when that kind of messaging goes out, violence against people who are unhoused goes up.” […] I soon discovered in my research that I was hardly the first person that progressive elected officials and homelessness advocates had accused of fomenting violence against unhoused people. Many others had been criticized for far worse over the years, including San Francisco’s highest elected officials. “The criticism [by progressive homelessness advocates] was heavy, political and personal,” wrote former mayor Willie Brown in his 2008 memoir. “People accused me of abandoning the problem when I was working daily to try and get a solution going. It was brutal. . . . I had become demonized, and my own efforts belittled.” It is notable that the result of such personal attacks is to frighten off people seeking to change, and perhaps improve, the situation. “The problem” of homelessness, concluded Mayor Brown within nine months of entering office, “may not be solvable.” And [Quoting Chris Rufo]. “The chief of psychiatry in a public hospital system in one of the largest California cities told me, ‘I know for a fact, and all of my colleagues know, that what we actually need to deal with the problem in the biggest cities in California is long-term residential secure psychiatric care. But I can’t say that publicly because I would be disemboweled by the activist left. My job would be in jeopardy. My reputation would be in jeopardy. My whole life would get turned upside down for even broaching the subject of expanding secure mental health facilities and compulsory mental health treatment.’ And I said, ‘So what’s the solution?’ and this person said, ‘We muddle through.’” And: In San Francisco, radical left activists protested [African-American] Mayor London Breed in front of her home. Breed said the protesters were “all white people. But that didn’t bother me as much as the taunting of me coming outside with firework torches in their hands looking like what used to happen when the KKK would show up to black people’s houses to burn their houses down.” While I was reading the book, I came across this tweet, which suggests that being unimpressed with SF’s lefty homeless activist scene is not limited to Michael Shellenberger: Claim 9: European Cities Like Amsterdam Successfully Solved Their Own Drug And Homelessness Problems By Doing The Opposite Of SF Shellenberger bases his plan to solve these problems on ideas that he says were pioneered in Amsterdam and spread to other European cities. In the 1980s, Amsterdam had the kinds of problems San Francisco deals with now: open-air drug markets, overdose deaths, homelessness, and crime. But in the 90s, they admitted they had a problem and took decisive action: What’s the secret?” I asked him. “Amsterdam has decriminalized marijuana and many other drugs but I haven’t seen any homeless. What is San Francisco doing wrong?” Rene said that in the 1980s, the Zeedijk neighborhood in Amsterdam was a lot like the Tenderloin [the worst part of San Francisco] today. There was open-air drug use, particularly of heroin, and needles strewn about, as well as crime. People started to flee the neighborhood, worsening its slum conditions. Homeless people squatted in abandoned buildings. “We had ghettos where it was not safe to go,” said Rene, who started working in the neighborhood as a nurse in 1985. It was considered a “no go” zone. “We had a lot of people from abroad who came to Amsterdam because our heroin was so good. But our heroin was so good that they died from it.” At first the city tried a “helping approach” exclusively, offering addicts clean needles, methadone, and other forms of help without any law enforcement, but it didn’t work. “In the eighties we just wanted to help people,” said Rene. “We started with methadone programs and medical treatment. We did a lot of work without much of a carrot and a stick. It was really a disappointment. They just used the methadone to stay addicted. They dealt drugs and committed other crimes. They lied and cheated about it. We were just supporting a different kind of market. We had to learn the hard way [...] The Amsterdam City Council asked the Amsterdam Municipal Health Service to develop a strategy to deal with “unmotivated drug users”...The police broke up the open-air drug scene and health workers were on hand to offer methadone, treatment, and shelter. The police broke up gatherings of more than four or five users, but did not treat personal and private use as a crime. Officers ticketed violators, and if users did not pay their fines, which was frequent, the courts ordered arrests, and sentenced individuals to follow a treatment plan or face incarceration. “For every individual homeless person, we make a plan,” said Rene. “We made tens of thousands of those plans.” Plans are overseen by a caseworker and a team that may include a psychiatrist, shelter provider, service provider, judge, employer, parole officer, and police officer. “You need people in the police and health department working together,” he said. What Amsterdam did was the same as other major European cities. Lisbon, Frankfurt, Vienna, and Zurich all dealt with their open-air drug markets, using a combination of law enforcement and social services. Crucially, Amsterdam and other European cities prevented services from being concentrated in a single neighborhood, since their concentration often enables an open-air drug scene to thrive [...] The efforts worked. “We had several thousand people who were addicted to heroin in the eighties and nineties,” said Rene. “Many died. Today we have four or five hundred people addicted to methadone. And we have about 120 in Amsterdam who we supply heroin to on a medical basis because methadone doesn’t work for them. They have to use heroin.” The Amsterdam strategy goes something like: Break up open-air drug markets and anywhere that more than 4-5 drug users are congregating. Yes, people can just use their drugs in private, but this is legitimately better. Open-air markets normalize drugs with their blatantness, and make it hard to quit for the same reason it’s hard to diet if your partner leaves boxes of donuts out in the house every day.
Inline links: Housing First For Homeless People With Active Addiction: Are We Overreaching?, here, https://substackcdn.com/image/fetch/$s_!sgvd!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F5250de4e-08fe-460d-87a6-58654d6e57bf_880x292.png, 24-month followup, https://substackcdn.com/image/fetch/$s_!OZrF!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2Facb2c749-e076-4b50-ae77-83576401a16f_556x639.png, a proper randomized study, Somers, Moniruzzaman and Palepu, Padgett et al, Kirst et al, Milby, a $14 billion budget, This article, talk about, another article about people objecting to, boarding houses, Politico, has completed only 700 units, Considerations On Cost Disease, this comment, An article, https://substackcdn.com/image/fetch/$s_!4wi2!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F00f02bfe-c696-415d-ba80-5edb997021cb_809x487.png, survey, This app, this webpage, this site, many people, among the strongest proponents of both, these numbers, here, https://substackcdn.com/image/fetch/$s_!msoV!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F8b34d51f-d6ed-43ee-a069-5e74fe75c421_1812x1102.png, an anti-drug Australian think tank, https://substackcdn.com/image/fetch/$s_!CN2E!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F85656c06-22bc-4076-80f0-b7a9bd4aa0d3_574x331.png, A Resounding Success Or Disastrous Failure: Re-examining The Interpretation Of Evidence On The Portuguese Decriminalisation Of Illicit Drugs, https://substackcdn.com/image/fetch/$s_!VvrE!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F2341944a-388d-4da9-9788-8474567b83fc_540x737.png, Ed West, Public Policy Institute, UCI criminologists, Applied Divinity Studies’ article, https://substackcdn.com/image/fetch/$s_!aTNC!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2Fa27aeb21-ed87-4e67-b82c-b3ceecee7082_500x238.png, here, Here’s the San Francisco subreddit’s response, https://substackcdn.com/image/fetch/$s_!_NL6!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2Fcf7dc478-45d3-487d-8c29-8bc7cdf182dd_2400x1500.png, LouB’s analysis here, This news article, only 2.3% of shoplifting cases result in an arrest, New York Times, the Economist, https://substackcdn.com/image/fetch/$s_!58I3!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2Fc63dc7bc-1f8e-49fd-9c68-61c85278d69e_608x662.png, San Francisco’s ‘Crime Wave’ Is Just One Crime, https://substackcdn.com/image/fetch/$s_!h17s!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F956c0917-2a9b-4ff7-a08e-6aee5030583a_590x376.png, https://substackcdn.com/image/fetch/$s_!TkFS!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F5c5faa01-ac22-48a2-96fe-47efb6f52514_616x334.png, source, https://substackcdn.com/image/fetch/$s_!Bg2w!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F18e49c63-16ba-4878-96e6-aec12d7c5953_481x667.png, percent African-American, percent Borderer, here, the Twinkie Defense, https://substackcdn.com/image/fetch/$s_!8wK3!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F683b9754-f663-47ad-88f5-aa99bc208ec8_1401x622.jpeg, https://twitter.com/weheartprez/status/1526983899309432832
Continuing from San Fransicko: There is evidence that privacy and solitude created by Housing First make substance abuse worse. A study in Ottawa found that, while the Housing First group kept people in housing longer, the comparison group saw greater reductions in alcohol consumption and problematic drug use, and greater improvements to mental health, after two years. “One reason for the surprising results,” wrote the authors, “may be that aspects of the Housing First intervention, such as the privacy afforded by Housing First and harm reduction approach, might result in slower improvements around substance use and mental health.” Okay, but the next sentence after the one the book quoted was the researchers admitting that oops, we also totally forgot to randomize our groups in any way, so the experimental and control groups had totally different levels of severity and maybe that was why they found this weird thing (this is non-obvious, because we’re looking at change over time rather than raw differences between groups, but the authors discuss some reasons why different groups might change differently over time). A few years later these same researchers did a proper randomized study and it found no difference in drug use between the two groups. Somers, Moniruzzaman and Palepu found no difference in drug use between Housing First and other subjects. Padgett et al found the Housing First group actually did better, although they are another victim of the epidemic of randomization failures in this space. Kirst et al, no difference in drug use, but Housing First better with alcohol. Milby found that housing contigent on abstinence worked better than housing not contigent on abstinence, which Shellenberger could have used to support his thesis, but even Milby found that housing not contingent on abstinence worked better than no housing! To summarize: I can find seven studies on this topic, only one of them agrees with San Fransicko’s thesis, and the authors admit that it’s weak. I accuse San Fransicko of citing only that one and pretending all the others don’t exist. (actually, I accuse it of doing that plus citing a line from a review claiming another study found this, but as far as I can tell that study did not actually find it) This is extra annoying, because all the popular news articles on Housing First gush about how it definitely decreases substance use and everything else bad. Shellenberger could have made the excellent point that all of these progressive journalists were totally wrong! This would have been an interesting, important, and completely true act of virtuous data journalism! Instead he tries to hold up a lonely negative result as representative, and ends up just as wrong but in the opposite direction. Continuing in San Fransicko: Researchers have found ways to use housing to reduce addiction. Between 1990 and 2006, researchers in Birmingham, Alabama, conducted clinical trials of abstinence-contingent housing with 644 homeless people with crack cocaine addictions. Two-thirds of participants remained abstinent after six months, a very high rate of abstinence, compared to other treatment programs. Other studies found that around 40 percent of homeless in abstinence-contingent housing maintained their abstinence, housing, and jobs. In a randomized controlled trial, homeless people were given furnished apartments and allowed to keep them unless they failed a drug test, at which point they were sent to stay in a shelter. Sixty-five percent of participants completed the program. Three similar randomized controlled trials also found moderate to high rates of completion. And participants in abstinence-contingent housing had better housing and employment outcomes than participants assigned housing for whom abstinence was not required. All of this seems basically true. It turns out that over longer periods of time, Housing First may not even outperform contingency in terms of keeping people housed. In the spring of 2021, a team of Harvard medical experts published the results of a fourteen-year-long study of chronic homeless placed into permanent supportive housing in Boston. Most studies of permanent supportive housing, including the Kushel study conducted in Santa Clara, only study the newly housed homeless for a span of around two years. The study found that 86 percent of the homeless, who were referred based on length of time living on the streets, suffered from “trimorbidity”—a combination of medical illness, mental illness, and substance abuse. The authors found that after ten years, just 12 percent of the homeless remained housed. During the study period, 45 percent died. The authors concluded that, because the chronically homeless had such higher rates of physical and mental illness, “the supportive services, essential to the PSH model, may not have been sufficient to address the needs of this unsheltered population.” This study was done on an especially severe subgroup of homeless people. There was no control group, so Shellenberger shouldn’t claim we have any evidence about whether Housing First can “outperform contingency”. Shellenberger counts people who died as “unhoused” to get his 12% number; if he didn’t do this, the number would be 23%. Only 23% of people given housing retained after ten years sounds bad. But you could change this number to whatever number you wanted by changing the severity of the subgroup selected for the study. Select people who are even crazier and more disturbed than these people, and you can have 0% retained after ten years; select high-functioning people with no problems, and you can get 100% retained after ten years. (or maybe not - the study doesn’t say why people left the program. It mentions that one possible outcome is having to go to a nursing home because they had grown too sick or old to support themselves. I am not sure that “23% stay in this program” means “77% are back on the street and all their care has been a total failure”.) Conclusion: Housing First seems to work in getting people housing. It probably also helps people use fewer medical services, and it might or might not save money compared to not doing it (probably more likely when treating very severe cases, less likely in areas with high housing costs). It probably doesn’t affect people’s overall health or drug use status very much. San Fransicko is right to call out all the people promoting it beyond what the evidence supports, but then goes on to attack it beyond what the evidence supports. Interlude: Why Can’t We Just House All The Homeless? This is the question many of the California gubernatorial candidates asked. California has lots of money. There aren’t that many homeless people. Everyone is already committed to Housing First. So why don’t they have houses already? San Francisco has about 7,000 homeless people. The median SF apartment costs about $3,000 per month (presumably the government officials in charge would be trying to buy cheaper-than-median apartments for this project, but they seem bad at that, so let’s stick with median as a high-end estimate). So that’s $250 million/year to rent every homeless person an apartment. San Francisco has a $14 billion budget, although some of that is locked in nondiscretionary programs. So this effort would take about 2-3% of the city budget. Given how many people have both altruistic and selfish objections to the current level of SF homelessness, I can’t imagine that isn’t a better use of the money than whatever it’s being spent on now. So why hasn’t this happened? The closest thing I can find to the “rent apartments” plan is Governor Newsom’s “rent hotel rooms” plan, Project Roomkey. This was a short-term pandemic program. This article says it cost $4,000 per month, which seems reasonable - it provided residents with a hotel room, meals, security, and “custodial services” for just above a hundred dollars a day. So how come nobody has made it permanent or scaled it up? The homeless themselves don’t seem very positive on the project. They talk about “jail”-like conditions, including curfews and bans on visitors. I don’t know if this is the usual nanny-state-ism, or an attempt to reassure hotel owners / other residents / local communities that the influx of homeless people won’t cause them problems. If the latter, it hasn’t worked. From here: Jenna Abbott, executive director of the River District Business Association, said having a Roomkey motel in her neighborhood has been difficult. The site — which is in an area with large number of unhoused people — has drawn family and friends of Roomkey residents who haven’t been housed but “camp close to that hotel,” some with the goal of gaining a room, Abbott said. That’s led to more loitering, public drunkenness and trash outside the restaurants, gas stations and other businesses in the area, she added. And here’s another article about people objecting to local hotels accepting homeless people, which focuses on some combination of zoning, code, and public safety concerns. Everybody - the homeless, their advocates, various experts - interviewed in the article - agrees that the hotel rooms are kind of dehumanizing and much worse than having real housing. And this article suggests that government budgeters believe it’s not cost-effective compared to alternatives. Since the homeless don’t like it, and it’s expensive, almost everyone seems to agree it made sense as a short-term COVID measure only. The government’s preferred medium-term solution is single resident occupancy (SRO) hotels. These are big apartment/hotel-like structures where everyone has a small bedroom and then there are communal bathrooms and maybe kitchens. These used to be the archetypal living situation for poor Americans (Matt Yglesias talks about them as “boarding houses” here). But moral reformers banned them in the 1900s on the grounds that they were slums - I think this is the usual “surely the reason poor people live bad lives is because capitalists oppress them by selling them cheap low-quality goods, and if we just ban selling people cheap low-quality goods, everyone will have high-quality goods and poor people will live great lives!” argument. Somehow this failed to work and homelessness got worse over this period, but there are still some SRO hotels left, and the government got them and converted them to public housing for homeless people. Shellenberger does not have high opinions of these: The Tenderloin [district of San Francisco]’s single resident occupancy hotels . . . have for decades been dominated by a culture of heavy substance use and prostitution. “Of the people in supportive housing in San Francisco, 93 percent have a major mental illness that we can name,” said a housing policy maker. “That is very, very high. Eighty percent use cocaine, speed, or heroin every thirty days, or get drunk to the point of unconsciousness.” Tom Wolf, a former Salvation Army caseworker and a member of San Francisco’s Drug Dealing Taskforce, says the city’s supportive housing facilities are themselves a major market for illegal drugs. “Go down the street to the Camelot Hotel on Turk Street,” said Wolf. “Almost everyone that I’ve seen in those hotels are using. The last front desk guy that was working there got busted because he was selling crack. The actual guy that works in the single resident occupancy hotel is selling crack! It’s insane, man.” In any case, there are only so many of these still left. The government often announces plans to buy defunct regular hotels and convert them into these structures, which would indeed be a medium-term solution for housing the homeless, except that they usually get bogged down in fights about code. Politico discusses one of these attempts in New York City (h/t Marginal Revolution): “There are very few hotels that physically could be converted and comply with the requirements of today’s zoning and building code without substantial, expansive reconstruction, partial removal or demolition,” said James Colgate, a land use partner at Bryan Cave Leighton Paisner LLP who has advised clients on zoning issues including the conversions of hotels. “That would increase the costs greatly.” For example, a building’s elevators, doorways, or rooms may be slightly short of the size required for a residential structure. Residential buildings are also required to have a certain amount of rear-yard space that a hotel may not have. “You would literally have to be chopping off part of the building,” Rosen said. …The legislation dictates that each unit include a kitchen or kitchenette with a full-sized refrigerator, cooktop and sink — something Rosen said made utilizing the program “simply too expensive.” “This is the classic case of the perfect being the enemy of the possible,” said Mark Ginsberg, a partner at the firm Curtis + Ginsberg Architects, which has worked on hotel conversions. Some advocates who pushed the creation of the program say those provisions were necessary to ensure it didn’t generate substandard housing […] “We didn’t want a program that cut corners to make it more palatable to developers,” said Joseph Loonam, housing campaign coordinator for the progressive advocacy group VOCAL-NY. “We wanted a program that centered the needs of homeless New Yorkers, which is true high quality affordable housing where they can have full autonomy and dignity.” As Marginal Revolution pointed out, Loonam got what he wanted; the expensive, over-regulated program was unpalatable to developers, with only one company putting in an offer; for whatever reason, NYC refused to go with that one company, and no housing was produced. But fine, these are also terrible, and they’re only medium-term solutions anyway. What about building real, long-term apartments for homeless people? Shellenberger tells the story of Los Angeles’ Proposition HHH, which raised $1.2 billion to do exactly this. They hoped to build ~10,000 units for the homeless, at a projected price of $140,000 each; since LA had about 30,000 homeless people at the time, this would solve a third of the problem - a good start. (how do these numbers line up with my back-of-the-envelope calculation for SF above? I talked about renting rather than building, but usually annual rents = 1/20th or so of total prices, so I was estimating about $700,000 per person. This is probably partly because SF costs more than LA, and partly because I was imagining median apartments whereas LA is probably working on very cheap apartments) But in fact, five years later, LA has completed only 700 units, and the cost per unit has spiralled to $531,000 each. Nobody has a good explanation for what happened, with Shellenberger quoting one local service provider who said a lot of it was “bullshit costs”. Now might be a good time to re-read Considerations On Cost Disease. [Update: this might not be accurate - see this comment] This seems to be a general problem: everyone is committed to Housing First and to long-term good solutions rather than short- or medium- term mediocre ones. But that means building housing. And some combination of NIMBYism and over-regulation means building housing is somewhere between ruiniously expensive and impossible. Claim 4: Shelters Are Unpopular Among Progressive Activists And The Homeless Themselves San Francisco doesn’t have more homelessness than eg New York, but almost all the homeless in New York live in shelters and stay off the street. Why doesn’t that work here? Shellenberger: In the context of cities with permissive attitudes toward drugs, like San Francisco, many homeless people stay in [tent] encampments to use illegal substances more freely and easily than they can in the shelters. Many policy makers understand this. “I went out with a team twice to have conversations with people to get an understanding of what they’re dealing with,” said Mayor Breed in 2020. “It was absolutely insane. Most of the people did not take us up on the offer [of shelter and services].” Even people who would prefer to live in sober environments say they do not want to quit their addictions. “When we surveyed people in supportive housing in New York,” said University of Pennsylvania homelessness researcher Dennis Culhane, “almost everybody wanted their neighbors to be clean and sober but they didn’t want rules for themselves about being clean.” In 2016, after the city of San Francisco broke up a massive, 350-person homeless encampment, dozens of the homeless refused the city’s offers of help. Of the 150 people moved during a single month of homeless encampment cleanups in 2018, just eight people accepted the city’s offer of shelter. In 2004, just 131 people went into permanent supportive housing after 4,950 contacts made by then-mayor Newsom’s homeless outreach teams. An article by a former homeless person explains the problems with shelters beyond just “can’t use drugs”. Residents are crammed into a small space with 300 other homeless people. Lice and bedbugs are everywhere. Everybody catches every disease. Everybody has stories about getting raped or beaten up. Invasive moralizing about drugs somehow exists side by side with rampant drug use. Shelters are gender segregated, which means straight people can’t stay with their partner. Most shelters ban children and nobody has any idea what to do with them. Most shelters ban pets - a lot of homeless people have dogs for protection or companionship, and you can’t just store them somewhere while you’re sheltering. Although some lucky people can get 90-day beds, other people need to apply for beds on a day-by-day basis, which requires waiting in line several hours every day. Users talk about rampant cutting in line, denying cutting in line, false accusations of cutting in line, etc. Most shelters kick people out between 9-5, either to save on staffing costs or in the hopes that they’ll get a job. But many have strict curfews requiring people to be back by 5 PM sharp, which can make jobs impossible - if your boss doesn’t let you out until 5 and you have a half-hour commute, how do you get back to the shelter on time? Results of a survey at one of SF’s new Navigation Centers at why their clients refused to go to normal shelters. But even the homeless people who do want to go to shelters mostly can’t get in. This app gives the current status of San Francisco’s homeless shelter waitlist. If you applied today, there would be 900 people ahead of you in line for one of the city’s 1500 - 2500 shelter beds. The app says that the median wait time is 826 days. So however many homeless people don’t want to go to shelters, we’re not building enough shelters to serve the ones who do. Why not? Shellenberger again: In the spring of 2021, Friedenbach published an op-ed opposing a proposal considered by the San Francisco Board of Supervisors to create, within eighteen months, sufficient homeless shelters and outdoor “Safe Sleeping Sites” for all of the city’s unsheltered homeless. “One can simply take a look to New York City,” she wrote. “Their department spends about $1.3 billion dollars of its budget on providing shelter for their unhoused population while thousands remain on the street. . . . As a result, New York has a higher rate of homelessness than San Francisco.” Housing First advocate Margot Kushel of the University of California, San Francisco agreed. “The problem with New York—and I spend a lot of time with people working in the system in New York—is that they spend an estimated $30,000 for each person per year to keep them in shelter. That’s not what we want to do. Because if you create the shelter and you don’t create the housing, then people are just in shelter forever.” Housing First advocates oppose shelter in Los Angeles. “Why haven’t we solved homelessness?” asked Housing First creator Sam Tsemberis. “Because [Los Angeles mayor] Eric Garcetti [has] Andy Bales [saying,] ‘You need emergency housing.’ ‘These people need to be cleaned up.’ ‘They need to be sober.’ ‘They need Jesus before they’ll be ready for housing.’ I said, ‘People should be housed and then maybe they’ll get sobriety and Jesus and the rest.’ We’re definitely on polar opposites of the whole thing.” Advocates for the homeless at the national level similarly oppose more shelters. “I don’t agree that we should be building more transitional housing,” said the head of the National Alliance to End Homelessness. […] In other words, the reason that there are so many homeless people on the streets in San Francisco is that both progressive and moderate Democratic elected officials, and the city’s most influential homelessness experts and advocates, have for two decades opposed building sufficient shelters. And that is unlikely to change even after San Francisco starts spending hundreds of millions more per year on the problem and might even get worse. This basically seems true. I found this webpage of a former SF Supervisor candidate a helpful corroborating source. He was running on a platform of “maybe we should build some homeless shelters”. He lost. You can also find a bunch of webpages by the sorts of people Shellenberger is complaining about, for example this site: Sup[ervisor] Rafael Mandelman today pushed his new legislation that would require the city to offer at least temporary shelter to everyone living on the streets, a step that some say would lead to more homeless sweeps and do nothing to create permanently affordable housing . . . [our] Coalition has argued for years that the solution to homelessness is housing—not temporary shelter, which may never lead to housing. The ex-supervisor candidate gives some helpful numbers: permanent housing costs about $600,000 per person housed. Shelters cost between $20,000 and $30,000 per person housed. So SF could build enough shelters to clear its waitlist for about $30 million. More recently, SF has tried a sort of compromise, opening “deluxe” shelters called Navigation Centers which avoid some of the problems of regular shelters. They also cost more than twice as much, and the city has only created about 300 beds. Also, the people in regular shelters are angry, because being in a regular shelter disqualifies you from getting into a (much better) Navigation Center. Some of them are considering leaving their shelter, going back on the streets, then waiting however many months or years it takes to get a Navigation Center bed instead. I’m not at all sure of these numbers, but it looks like of SF’s ~7,000 homeless, about 2,000 are in shelters already, and 1,000 are on the shelter waitlist. I don’t know if the remaining 4,000 have made a specific commitment not to go to shelters, or just have given up on the waitlist process. My conclusion: agree with San Fransicko about the role of progressive activists, but I think it overemphasizes the role of wanting to use drugs in why homeless people themselves sometimes avoid shelters, and underemphasizes the many other problems with them. Claim 5: Drug Decriminalization Isn’t Working California legalized marijuana in 2016. Shellenberger says that San Francisco’s commitment to drugs has gone beyond that: it has effectively decriminalized opioids, cocaine, and the rest. Any attempt to lessen use of these drugs is attacked as “stigmatizing”; instead, government policy centers around providing addicts with needles and other drug paraphernalia under the guise of “harm reduction”. Shellenberger hits all the right beats here. Like many people, he tries to undo the damage done by The New Jim Crow, a book which convinced millions of people that mass incarceration was driven by a racist War On Drugs. In fact, less than a fifth of prisoners are in for drug-related crimes. And when the government was first debating the War on Drugs and mass incarceration, black leaders were among the strongest proponents of both. The talking point at the time - among everyone from black Congressional leaders to black churches - was that the government’s failure to crack down on drug use was racist, borne of them not caring about predominantly black drug victims. And while we’ve been patting ourselves on the back about how enlightened we are for ending the drug war: Drug overdoses are today the number one cause of accidental death in the United States as a result of America’s historic addiction and overdose epidemic. Overdose deaths rose from 17,415 in 2000 to 93,330 in 2020, a 536 percent increase.Significantly more people die of drug overdoses today than of homicide (13,927 in 2019) or car accidents (36,096 in 2019). […] There are about twenty-five thousand injection drug users in San Francisco, a number 50 percent larger than the number of students enrolled in the city’s fifteen public high schools. San Francisco gives away more needles to drug users, six million per year, than New York City, despite having one-tenth the population. The part of this chapter that stood out to me as most worth looking into deeper was the section on Portugal: For decades, harm reduction and decriminalization advocates have pointed to Portugal as a model, noting that it decriminalized drugs and expanded drug treatment. In 2013, Portugal’s drug-induced death rate was sixty-six times less than that of the United States. The number of people in treatment increased by 60 percent between 1998 and 2011, with three-quarters receiving an opioid substitute like methadone or Suboxone, the brand name of buprenorphine. Drug use among 15- to 24-year-olds actually declined after decriminalization. “All drugs have been legalized,” explained Monique Tula, executive director of the Harm Reduction Coalition. “Their focus is on giving people tools, like job apprenticeships, and the means to support themselves.” […] [But Portugal] never legalized drugs. It only decriminalized them, reducing criminal penalties but maintaining prohibition. Drug dealers were still sent to prison even after the 2001 decriminalization. And Portugal does not let people addicted to hard drugs with behavioral disorders off the hook like progressive West Coast cities have done. It’s true that Portugal massively expanded drug treatment, but people are still arrested and fined for possession of heroin, meth, and other hard drugs. And drug users are typically sent to a regionally administered “Commissions for the Dissuasion of Drug Addiction,” composed of a social worker, lawyer, and doctor who encourage, push, and coerce drug treatment. And decriminalization doesn’t end drug violence. “Even if trafficking enforcement decreased, like it did in Portugal,” said criminologist John Pfaff, “illegal drug markets would still be forced to rely on violence to resolve disputes.” Indeed, prostitution and violence are ever-present in the open-air drug scenes in San Francisco, Los Angeles, and Seattle. “We are seeing behaviors from our guests that I’ve never seen in thirty-three years,” said Rev. Andy Bales, who runs the largest homeless shelter on Skid Row in Los Angeles. “They are so bizarre and different that I don’t even feel right describing the behaviors. It’s extreme violence of an extreme sexual nature.” People are not dying from drug overdose deaths in San Francisco because they’re being arrested. They’re dying because they aren’t being arrested. Decriminalization reduces prices by lowering production and distribution costs, which increases use. This was also the case for alcohol consumption. It increased after prohibition ended in the United States. Even in Portugal, drug overdose deaths and overall drug use rose after decriminalization. I was most surprised by the claim that Portuguese overdose deaths rose after decriminalization. Uncharacteristically, San Fransicko doesn’t give a citation for it, but we can try to retrace its reasoning. Decriminalization proponents tend to point to these numbers, helpfully converted to per 100,000 population and graphed here: But an anti-drug Australian think tank argues that the peak in 2001 is made up: Claims that there were more than 75 drug-related deaths in 2001 which more than halved to 34 deaths in 2002 use a figure for 2001 for which there is no substantiation. Official drug-related deaths for Portugal, taken from the latest 2018 EMCDDA Statistical Bulletin are copied below. Notice that there is no such figure recorded for 2001. They include a link to EMCDDA, the EU organization charged with monitoring these things. The link contains two datasets, both of which seem to be measuring the same thing but getting different results. One dataset starts in 2002, the other in 2008. I don’t know what the difference here is, but they’re right that neither includes 2001. If you ignore the pre-2002 data, the graph looks like this: They say “opiate”, but AFAICT these numbers are actually about all drugs. But the proponents link to the updated 2020 version of the same website, which all of a sudden does have data from 2001 and before. I don’t know why EMCDDA can’t make up its mind, but I think the Australians are wrong and the original graph is fine. On the other hand, does it really matter? Both of these show drug deaths decreasing until 2005, then going up and down a bit, then going back up again starting in 2011. I think a reasonable interpretation would be that decriminalization in Portugal did decrease overdose deaths a bit, and then they started rising again from that low baseline around the same time other European countries saw rising overdose deaths. I would also accept “these are pretty small effects and we shouldn’t ascribe any significance to them”. But San Fransicko’s claim - that overdose deaths increased after the reform - seems false. The only way I can see justifying it is taking the second graph - the one that wrongly claims there is no pre-2002 data - and then attributing the fact that twelve years after the reform lowered deaths, deaths finally rose above the pre-reform level to be the fault of the reform. This is like saying “people claim the Black Plague killed a lot of Europeans, but the European population actually rose after the Plague”, which is true in the sense that it was above its pre-Plague max by like 1600 or whatever. What about overall drug use? Here I recommend A Resounding Success Or Disastrous Failure: Re-examining The Interpretation Of Evidence On The Portuguese Decriminalisation Of Illicit Drugs, which is on exactly this topic of how people keep selectively quoting results from Portugal to prove their point. It argues that drug use is inherently hard to measure. There are four different Portuguese datasets for the time at issue, lots of different drugs, lots of different age/gender combinations, and lots of different ways of measuring drugs (did you use drugs in the past month? the past year? your lifetime?) It’s easy to tell a story of how past-month cocaine use skyrocketed among 14-29 year old males according to X source, or how lifetime marijuana use fell in high school-age women according to Y. The main trick that opponents use is measuring lifetime drug use. Portugal is a very conservative country; drug use is pretty new and most of the older generation wasn’t involved. So as time goes on and more and more people try drugs but “un-trying” drugs isn’t a thing, the percent of the population who have tried drugs inevitably goes up. This definitely happened but isn’t a fair reflection of any specific reform. The authors find that in the past decade or so, there has been a bit more short-term experimentation with drugs, but less long-run use. They conclude: As shown in Figure 2, general population (aged 15–64) trends for recent and current drug use in Portugal indicate minimal if any changes between 2001 and 2007. Instead, rates of discontinuation of drug use (the proportion of the population that reported ever having used a drug but opting not to in recent years) increased, which reinforces that just as in the school populations, the growth in lifetime-reported use reflected predominantly short-term experimental use. Increases in recent and current drug use were more notable in some cohorts, particularly those aged 25 to 34 (albeit, with a maximum of 7% of any one cohort reporting recent use, absolute levels remained low). But as shown in Figure 3, recent and current drug use declined among those aged 15–24, the population who were most at risk of initiation and long-term engagement. The available evidence thus gives grounds for arguing that while there was some growth in the scale of drug use in post-reform Portugal, there was an overall positive net benefit for the Portuguese community. What about San Fransicko’s main point - that as the US has wound down the War on Drugs, drug overdose rates have sextupled? I think this is mostly not causal. I think the sextupling of overdoses is a combination of expansion in prescription opioid use, various forms of social decay making people less happy and therefore more likely to use drugs, and “improvements” in drug “technology” and the “supply chain” (eg production of fentanyl in China). I don’t know of any source that attempts to tease out the exact contribution of all of these things, but I would note that overdose deaths have risen the most in very conservative Midwestern states that haven’t walked back the drug war as much as California. Conclusion: As usual, I appreciate San Fransicko’s corrections to the prevailing narrative, but its own additions are dubious. Its claim that Portugal saw increased drug-related deaths seems false as far as I can tell. Its claim that it saw increased drug use depends on your definition, but is misleading and not the most natural way to sum up the evidence. Claim 6: San Francisco’s Soft-On-Crime Policies Led To Rising Crime Ten years ago, the news was full of stories about how some teenager stole a gumdrop and was sentenced to nine hundred billion years in jail. At some point, there was a genre shift to stories about how some hardened criminal murdered fifty people with an axe and the judge let him go with a warning because having jails felt racist. Source: Ed West, do note that this example is from the UK How suspicious should we be of each type of story? There will always be an extreme right tail of overly harsh sentences, and an extreme left tail of overly lenient ones. Were the 2000s really as draconian as they felt? Is the modern era really as pathetic? Or is it all just a function of who you read and what agenda they’re pushing? Shellenberger: During California governor Jerry Brown’s time in office, voters passed several reforms aimed at reducing the size of the prison population. In 2012, voters passed a change to the Three Strikes law so that the third strike imposes a life sentence only if the new felony was serious or violent. In addition to lowering punishments for drug possession, Proposition 47, which voters passed in 2014, redefined shoplifting, forgery, petty theft, and receiving stolen property as misdemeanors when the value in question does not exceed $950. In 2016, voters approved a proposition that shortened the time it took for some nonviolent offenders to be eligible for parole and which released nonviolent offenders into drug treatment and rehabilitation. Property crimes rose in San Francisco starting in 2012. Larceny, which is shoplifting and other petty theft, rose 50 percent, from roughly 3,000 incidents per 100,000 people in 2011 to about 4,500 in 2019. Property crimes as a whole, which include larceny, motor vehicle theft, and burglary, rose from 4,000 incidents per 100,000 people in 2011 to 5,500 in 2019. One study suggests that Proposition 47 increased the rate of auto theft 17 percent and the rate of larceny (non-auto property) theft 9 percent, but discerning between causation and correlation may not be possible. Upon taking office in January 2020, [famously soft-on-crime San Francisco district attorney Chesa] Boudin followed through on his campaign promises. Instead of prosecuting and incarcerating people for breaking car windows to steal money and other items from inside, Boudin proposed creating a $1.5 million fund to reimburse car owners. But there were over 25,000 car break-ins reported in 2019. If every break-in cost just $250 in repairs, the fund would need four times that amount. And what would prevent people from falsely claiming to have been robbed in order to get city money? […] Boudin opposed efforts by the mayor and the city attorney to prevent drug dealers who had already been arrested from entering the Tenderloin. “Until the city is serious about treating addiction and the root causes of drug use and selling,” said Boudin in a statement, “these recycled, punishment-focused approaches are unlikely to succeed at doing anything more than making headlines.” Home burglaries rose in early 2021 in San Francisco. Homeowners started posting on Twitter videos from their security cameras of people breaking into homes and garages. “When I first moved here we had a car break-in problem,” said Michael Solana, a writer who works for a venture capital fund. “Now we have a home invasion problem. These things are wearing on people.” Boudin attributed the rise of burglaries in San Francisco to the decline of tourism and “people in desperate economic circumstances.” Progressive supervisor Hillary Ronen agreed. “We know that [economic insecurity and inequality] is one of the root causes of property crimes specifically,” she said. But Tom Wolf and others argued that the robberies were, like the shoplifting, done by people seeking money to buy drugs and feed their addictions. “The drugstores have been shoplifted to death and that’s all because of drug use,” said Tom. “I know. I used to do the same thing when I was out there. That’s what you do. You ‘boost.’ And then you go and you sell your stuff down at UN Plaza,” an open-air drug scene. In a May 2021 city supervisors’ meeting, a representative from CVS called San Francisco “the epicenter of organized retail crime in the country” and claimed that 85 percent of the shoplifting is committed by organized theft rings. Police broke up one such ring in October 2020 and recovered $8 million of stolen merchandise. The problem goes beyond property crime. Boudin declined to prosecute two men who went on to kill people. One man had been repeatedly arrested for stealing cars, despite having just been released from prison earlier in the year, and appeared to be abusing meth. On New Year’s Eve, 2020, the man killed two people while driving intoxicated. Police found inside of his car a semiautomatic handgun and twenty-three grams of methamphetamine. On February 4, another intoxicated driver killed a pedestrian in a stolen car. The San Francisco police had arrested him in October 2020 for possessing a stolen car, a tool for stealing cars, and what appeared to be meth. Boudin chose not to pursue charges. In December, the California Highway Patrol arrested the man again for driving a stolen vehicle under the influence. Again he was not prosecuted. The accident victim, an immigrant from Kenya, and his wife had moved to San Francisco two weeks before the fatal crash. “I blame the DA,” said the widow of the victim. The suspect, she said, “was someone who was out in the public who shouldn’t have been in the public. It was completely avoidable.” Tom said he could feel the difference on the streets. “Drug dealing is unabated and it’s not one guy, it’s fifty guys dealing fentanyl and meth,” he said. “And it’s going unabated because the district attorney says, ‘These are the nonviolent, quality-of-life crimes,’ and ‘I’m not going to prosecute them.’” [..] District Attorney Boudin was offering weaker sentences than even defense attorneys were requesting, according to Vicki Westbrook of San Francisco. “There’s a defense attorney who said, ‘It used to be that I would argue for this deal in court with the DA but now I don’t say anything because the DA is going to offer me a deal better than what I would have suggested. Somebody shot up the street with an automatic weapon. The first offer was six months in jail or time served plus two years of probation or something. And then [the DA] said, “How about thirty days in jail?”’” Vicki laughed. “You really can do anything in San Francisco,” she said. “If you do get arrested, chances are you’re going to be out of jail in less than thirty days for damn near everything except maybe killing somebody and maybe even then, too. It’s hard to say at this point.” Taking each of these points individually: Proposition 47 There are two good big studies on the effects of Prop 47, one by Public Policy Institute and one by some UCI criminologists. The PPI study finds that the proposition increased theft and car break-ins by about 10%. The UCI study finds the same, but notes that under different assumptions the effects wouldn’t quite obtain statistical significance. This seems a bit too much like post hoc trying to get rid of an inconvenient effect, plus an effect on the border of statistical significance is different from positively finding no effect. I think a reasonable interpretation is that theft and car break-ins rose about 10% because of the proposition, just as Shellenberger says. Some pro-47 sites note that most states have some limit on how much you to have to shoplift before it’s a felony, and Prop 47 brought California closer to the national average, rather than turning it into an outlier. Chesa Boudin Chesa Boudin took office two months before the COVID pandemic began. Any attempt to separate the effect of Chesa Boudin from the effect of the pandemic is doomed. Shoplifting definitely plummeted when Boudin took office, but that’s because all the stores were closed. Murders definitely rose a little after Boudin took office, but that’s because that was also when the Black Lives Matter protests happened, which demoralized police and led to a so-far-permanent spike in murders nationwide. Percent of criminals caught definitely fell when Boudin took office, but that’s because various aspects of the justice system were closed for COVID (I will grudgingly entertain speculation that a further decrease in arrest rates from 2020 to 2021 may have been a genuine Boudin effect). In the absence of any real way to judge his performance, I think San Fransicko’s points about Boudin are plausible, though speculative. Shoplifting This one is terrible. There’s a surprisingly spirited debate here (some of you may have already read Applied Divinity Studies’ article). The debate is: everyone on the ground in San Francisco - store owners, security guards, customers, random citizens - say that shoplifting has increased massively over the past decade. But statistics mostly say it hasn’t. Source here. This is shoplifting crimes per 100,000 people. Kern County is a deep red county in California (including Bakersfield) that is known for being tough on crime. Against this, seriously, everyone says that shoplifting has obviously increased. I had a patient who worked in shoplifting prevention, he told me - his psychiatrist! Who he had no reason to lie to! - that he was constantly stressed dealing with the shoplifting surge devastating the stores he covered. Here’s the San Francisco subreddit’s response to someone posting the data showing shoplifting hasn’t risen - it’s just a lot of people laughing hysterically. What’s going on? I was able to find a different set of statistics that does seem to show a longer-term increase in shoplifting (source): The very big spike at the end might be a change in reporting by one or two stores - you can find the argument here. But it does look like shoplifting went from about 125 incidents/month in the early 2010s to more like 250/month just before the pandemic. Why is this graph so different from the other one? It looks like the top one came from the Department of Justice, and the bottom one came from SFPD. I’m not sure why these report differently. When you multiply out by 800K people in SF, by 12 months/year, and 30ish days/month, the first graph corresponds to 4 shoplifting incidents per day, and the second to 6. As LouB’s analysis here points out, that seems suspiciously low for a city of 800,000 people where stores are constantly closing because of shoplifting. Maybe off by a factor of a few hundred from what we’d expect. LouB writes: The SFPD report only references shoplifting offenses that required SFPD officers to prepare an incident report. That means either the shoplifter fought security, committed additional crimes, or stole more than $950 worth of items. It’s not that SFPD’s report is erroneous, it’s just not a representative statistic. In a parallel statistic, SFPD only completes incident reports for traffic accidents when there is an injury. Therefore, thousands of noninjury accidents are handled civilly without SFPD reports the same way thousands of shoplifting offenses are handled without reports. An insurance company would not determine premium rates based solely on SFPD incident reports, nor should readers interpret SFPD shoplifting reports as anywhere near the total picture of the shoplifting epidemic in San Francisco. (this would also explain why one or two stores changing their reporting policy can produce a spike equal to everyone else in San Francisco combined) But comparing incident reports from 2010 to incident reports from 2020 should still be apples-to-apples, unless the likelihood of reporting any given incident changed in the meantime. Did it? This news article quotes a San Franciscan who says that when they try to report shoplifting incidents, the cops tell them not to because “it doesn’t make a difference”. If cops say that now more often than they used to, it would make all these statistics meaningless. (Applied Divinity Studies claims to have an argument that shows this can’t be true. It goes something like: if San Francisco was a better place to shoplift than its neighbors - eg Oakland - then shoplifters would leave Oakland to go to San Francisco, and we would see Oakland shoplifting rates falling. Oakland shoplifting rates are falling, but no more so than the rest of the state, so there can’t be increased tolerance for shoplifting in San Francisco. I find this dubious for many reasons. First of all, many of the same reasons shoplifting is up in San Francisco - like Prop 47 or soft-on-crime progressive policies - also apply to Oakland. Second, given that shoplifting fell massively everywhere because of the pandemic, it feels dubious to try to compare different cities; maybe one city had stricter pandemic lockdowns than others. Third, do criminals really shop around for friendly jurisdictions? If so, why are so many crimes like car break-ins, concentrated in “the bad part of town”? Why wouldn’t criminals leave the bad part of town for under-exploited areas with richer residents and less competition? Maybe criminals in fact aren’t very strategic or mobile? Maybe they don’t want to stand in the BART station and then take a half-hour train ride holding a bag of stolen goods?) Maybe a better argument against this being true is how stable the shoplifting rates have been over time. Wouldn’t it be weird if (let’s say) a tripling of the real shoplifting rates was matched by a third-ing of the reporting rates (rather than a halving or a quartering or whatever)? On the other hand, here’s Shellenberger with some helpful data: Some of this is probably because of Proposition 47, which made some forms of shoplifting punishable with citation rather than arrest (but wouldn’t that be a clear discontinuity rather than a gradual trend?) But overall it sure seems like shoplifting is being taken less seriously, which might encourage people to report less. Another statistic I see is that only 2.3% of shoplifting cases result in an arrest; I don’t know how this is different from the graph above with numbers in the 30s; maybe it involves different levels of what makes something a “case”. I accept that the data don’t consistently show a spike in shoplifting. But what’s the alternative? My patient who works in loss prevention in SF stores is lying to me? The nice elderly Chinese man who sold me my last pair of glasses and chatted to me about the rampant shoplifting in his mall was lying? The San Francisco police are lying? Walgreens pretends to be concerned about shoplifting as part of a dastardly plot to close a bunch of stores for no reason? Target and CVS pretend to care about shoplifting as part of a plot to restrict their stores’ opening hours for no reason? Every big store near me has suddenly gotten a security guard at the front as part of some corporate-sponsored jobs program? Maybe the conservative narrative that soft-on-crime San Francisco must be experiencing rising crime rates took on a life of its own. Maybe it infiltrated not just the usual suspects like the SF police unions, but even such supposedly-liberal bastions as the New York Times. Maybe lots of big corporations took advantage of the fake narrative to make unpopular business decisions they were planning on making anyway. And maybe ordinary San Franciscans, confronted with everyone telling them they were in a shoplifting epidemic, started paying more attention to security guards and petty criminals who had always been there, a sort of mass hallucination that gripped everyone in the city. I can’t rule this out. Americans thought crime was rising all throughout the early 2000s, when it was in fact way down. Or maybe some statistics that we already know are off by several orders of magnitude got off by an additional factor of two or so. I think this one is more likely, but I’m genuinely not sure. Other Crime From the Economist: The Center on Juvenile And Criminal Justice puts it even more starkly, arguing that “San Francisco’s ‘Crime Wave’ Is Just One Crime”: This are potentially susceptible to the same reporting bias as shoplifting. So what about homicide? Homicide is practically always reported and investigated, making it a gold standard in crime measurement. (source) Looks pretty good until 2019. I don’t expect to gain useful information post-2020; the pandemic and the post-George-Floyd murder surge will make it impossible to evaluate for local variation. What about compared to other places? For some reason this top 20 table fails to list Washington DC, which should be just before Atlanta. SF doesn’t make the top 20, although its neighbor Oakland does. Probably most murder variation in US cities is explained by percent African-American and maybe percent Borderer; with relatively few people in these groups SF was never in the running. I’m not sure if some abstracted version of the city with all demographic factors adjusted away would have an unusually high murder rate, but at that point it would be pretty distant from any interesting real-world question. You can see the leaderboard for other types of crime here; San Francisco is often in the top ten, but never the top three. As far as I can tell, San Francisco has seen a big spike in car breakins over the past few years, with no clear trend for other property crime, violent crime, or homicides. It’s not an outlier among American cities in any kind of crime. Conclusion of this section: San Fransicko’s specific claims are basically correct, but suggest a medium-term rise in SF crime which is mostly contradicted by the data. These show stable-to-decreasing murder, stable-to-decreasing violent and property crimes other than car break-ins, and large rises in car break-ins only. The data also show stable-to-decreasing shoplifting, but I’m not sure how much to trust them vs. common sense. Honestly, I’m pretty confused here and not sure what to think. Claim 7: Jim Jones (Of Kool-Aid Cult Fame) Used To Be The Chairman Of SF’s Housing Authority Okay, this isn’t really a statistical claim that I can research different perspectives on. Still, it’s so wacky that I couldn’t resist mentioning it in this review. Jim Jones, famous for killing everyone in his Guyana-based Jonestown cult with poisoned Kool-Aid, used to be the SF government’s top guy on homelessness. Shellenberger writes: Jones married and moved first to Northern California and then to San Francisco with his wife to start a church. He called it the People’s Temple. Jones believed he was the leader of a socialist revolution. He warned of nuclear war and claimed black people would be put in concentration camps. He became a hugely charismatic preacher among African Americans, the disaffiliated poor, and young transplants to the city looking for community. Scenes from the era show a remarkably large and diverse congregation smiling and singing. The People’s Temple grew and provided services. Jones cultivated two progressive San Francisco politicians, George Moscone and Willie Brown, and mobilized people to volunteer for their campaigns […] His son and a San Francisco historian believe he stole the mayoral election for Moscone in 1975. Historian David Talbot, founder of the progressive website Salon, points to evidence that Jones committed sufficient voter fraud to account for Moscone’s narrow 4,443-vote margin of victory. “We loaded up all thirteen of our buses with maybe seventy people on each bus, and we had those buses rolling nonstop up and down the coast into San Francisco the day before the election,” said Jones Jr. “Could we have been the force that tipped the election to Moscone? Absolutely! Slam dunk. He only won by four thousand votes.” When federal investigators looked into fraud claims three years later, they discovered that all of the records were missing from the city of San Francisco’s registrar of voters. Jones also boasted of providing Moscone with black women from his congregation for sex. One time Moscone, drunk and “accompanied by a young black woman whom the politician had kindly agreed to drive home,” crashed into another car. Another time, Moscone and Willie Brown “were with a black woman in an alley at two in the morning at some restaurant in North Beach,” said a local bar owner. State legislator “John Burton was part of that gang too. They were all using marijuana and cocaine.” Said Jones Jr., Moscone would “always be there at temple parties with a cocktail in his hand and doing some ass grabbing.” A Temple member overheard Jones speaking to Moscone the day after one of those parties saying, “I want to let you know that the young lady you went off with is underage,” adding, “Now don’t worry, Mayor, we’ll take care of you—because we know that you’ll take care of us.” Afterward, Moscone made Jones the chairman of the powerful San Francisco Housing Commission. Jones cultivated progressives with money and favors. He made large donations to the ACLU, the NAACP, and United Farm Workers. Jones and Moscone met privately with vice presidential candidate Walter Mondale on a campaign plane a few days before the 1976 presidential election, and Mondale praised People’s Temple shortly afterward. Jones met with First Lady Rosalynn Carter several times. Governor Jerry Brown praised Jones. Glide Memorial Church’s Rev. Cecil Williams loved Jones. There is a photo from 1977 of a smiling Williams awarding Jones the church’s “Martin Luther King, Jr. Award.” Jones used his perch as chairman of the Housing Commission to fight for housing for the poor. He tried to use eminent domain to acquire the International Hotel, a single resident occupancy hotel. After a court sided with the hotel’s owner, Jones mobilized seven thousand protesters to picket it. By mid-January 1977, the situation had become heated. There were rumors that protesters inside the building were armed with guns and Molotov cocktails. Jones lost the legal battle in 1977, and the tenants were evicted. But the drama was a publicity victory for Jones, which burnished his image as a white savior. A conservative member of the Board of Supervisors who was defeated in the mayoral election by Moscone accused the new mayor, the San Francisco Chronicle, and the rest of the city establishment of being blind to Jones’s extremism. “There’s no radical plot in San Francisco,” insisted Moscone, in response. “There’s no one I’ve appointed to any city position whom I regard as radical or extremist.” Willie Brown, a powerful state legislator from 1964 to 1995 before becoming mayor in 1996, “seemed oblivious to Jones’ hucksterism and demagoguery,” notes a historian. Brown was master of ceremonies at a dinner for Jones in the fall of 1976 attended by an adulatory crowd of the rich and powerful, including Governor Jerry Brown. “Let me present to you a combination of Martin King, Angela Davis, Albert Einstein . . . Chairman Mao,” he said, to loud applause. And yet Jones was contemptuous of Brown even as Brown did Jones more and more favors. Jones mocked Brown for his designer suits, sports cars, and women. Once, while Brown was addressing the congregation and Jones was seated onstage behind him, Jones flipped his middle finger up to mock him. San Francisco’s establishment stood by Jones even after a California magazine, New West, owned by Rupert Murdoch, published an exposé of Jones’s beatings of Temple members and financial abuses in August 1977. The article was written by a San Francisco Chronicle reporter and was meant for the Chronicle to publish. But the newspaper killed the story because it didn’t want to alienate Jones, whom it viewed as central to its plans to expand the Chronicle’s circulation in the heavily African American Fillmore District. Jones also managed to avoid investigation and prosecution in part by getting the district attorney to hire as deputy district attorney Jones’s longtime attorney and confidant. Progressives defended Jones against the New West article. At a rally in the summer of 1977, Willie Brown said, “When somebody like Jim Jones comes on the scene, that absolutely scares the hell out of most everybody occupying positions of power in the system.” Angela Davis sent a radio message broadcast over the cult’s compound, Jonestown, in Guyana. “I know you’re in a very difficult situation right now,” she said, “and there is a very profound conspiracy designed to destroy the contributions which you have made to the struggle.” After visiting Jonestown, the attorney to the Black Panthers said, “I have seen paradise.” Harvey Milk, too, was tarnished by his association with Jones. In the fall of 1977, Milk wrote to President Carter’s secretary of health, education, and welfare requesting that Social Security checks be sent to elderly Temple members in Guyana. “People’s Temple,” wrote Milk, has “established a beautiful retirement community in Guyana.” In truth, the cult was disintegrating. Jones separated families and lovers, pitted relatives against each other, and forced neighbors to inform on each other. Jones sent people who violated the rules to solitary confinement in “the Box,” an underground cubicle where people were held as prisoners for days on end. Others were drugged. Progressives who had spent thirty years fighting to close prisons and mental hospitals found themselves praising a man who had reproduced their worst practices. In November 1978 a Bay Area congressman flew to Guyana to investigate human rights violations at Jonestown with NBC News. Jones gave the delegation a formal reception at Jonestown. A Temple member surreptitiously passed a note to one of the delegation members, saying he and another member wanted to escape. They fled the next day after a Temple member tried to stab the congressman. Jones didn’t prevent them from leaving but then sent gunmen to fire machine guns at the delegation at the airport, killing the congressman and four others. A few hours later, 907 inhabitants of Jonestown drank Flavor Aid laced with cyanide and died. Two-thirds of the victims were African American and one-third were children. Jones had told them that if they didn’t drink it they would be killed by invading soldiers from a shadowy global military conspiracy intent on imposing fascism and torturing children. As people started crying in grief, Jones scolded them. “Stop these hysterics,” he said. “This is not the way for people who are socialists or communists to die.” Jones’s wife protested the murder of children and had to be forcibly restrained. “We didn’t commit suicide,” said Jones in a tape recording, “we committed an act of revolutionary suicide protesting the conditions of an inhumane world.” Few were as stained by Jonestown as Willie Brown and George Moscone. “Even as the bloated bodies of the dead were removed from the jungle and the wounded were airlifted by the U.S. Air Force to hospitals in the United States,” wrote a historian, “Brown said he had ‘no regrets’ over his association with Jones.” They repeatedly disavowed responsibility. Said Moscone, “it’s clear that if there was a sinister plan, then we were taken in. But I’m not taking any responsibility. It’s not mine to shoulder.” This is Shellenberger at his best: telling us crazy stories from the recesses of San Francisco history, maybe kind of spinning the narration in a way that makes all progressives seem guilty by association, but with the tale itself so gripping that it’s hard to be mad. And Jones wasn’t alone. This was the golden age of San Francisco cults, when (Shellenberger tells us) “more than half of all high school students in the San Francisco Bay Area reported at least one recruiting attempt by a cult member, and 40 percent reported at least three contacts.” This chapter of SF history came to an end in 1978, when Dan White, who had just resigned from San Francisco’s Board Of Supervisors (ie City Council) entered City Hall through a window and assassinated Mayor Moscone and fellow Supervisor Harvey Milk, then successfully got charges reduced to manslaughter through a legal manuever that has gone down in history as “the Twinkie Defense” (realistically the defense was that he was depressed, but reporters seized on a comment that implied it was because he ate too many Twinkies). Everything about 1970s San Francisco was like this. With the Mayor and his right-hand-man both dead, San Francisco leadership ended up in the hands of previously second-tier politician Dianne Feinstein. Feinstein was what passed for a moderate in 1970s SF (which meant she had been targeted for assassination by various left-wing groups - she survived when a bomb left on her windowsill failed to explode). In Shellenberger’s telling, she managed to clean up some of the mess and restore a semblance of normalcy. San Francisco never forgave her. Moscone - voting fraud committer, underage sex enjoyer, and Jim Jones’ bff - is beloved as a martyr in today’s SF, but (the book points out) Feinstein is so loathed that in 2021 the Board of Education voted to rename Dianne Feinstein Elementary School. The Moscone Center is 2 million square feet and can fit about 10,000 people. Not to be confused with the Moscone Recreation Center, Moscone Station, or Moscone Elementary School. Meanwhile, all Dianne Feinstein got was one lousy elementary school and the Tithonus package of eternal life without eternal youth. Claim 8: The Intolerant Left Shuts Down Debate On These Issues Another one that’s probably hard to do a randomized controlled trial on. You could probably predict that this one was coming - it’s a necessary narrative beat in this genre of book. I think this beat is good. My impression is that people who aren’t themselves public figures disagreeing with left-wing ideas still don’t understand how scary it is and how much hate you get. Maybe now that 2/3s of every political essay written over the past five years is about this topic, people will finally get it through their thick skulls that it exists and is bad. I would also note that “traumatizing the sorts of people who write popular books about politics, in a such a way that they feel compelled as a sort of self-therapy to write page after page telling readers how angry they should be at you and your whole coalition” isn’t great political praxis. I would like people to figure this out and stop doing it. Anyway, Shellenberger is doing his part in this effort: In 2001, the San Francisco Coalition on Homelessness wheat-pasted posters of a fake front-page San Francisco Chronicle across town. Just beneath the masthead a large headline read “Fuck the Homeless!” right above a picture of San Francisco mayor Willie Brown laughing. Below his photo was the headline “Save the Tourists.” Progressives level the same charges at people thirty years later. “Because of some of the stuff I say,” said a community activist in Seattle’s historically black Capitol Hill neighborhood, “people say, ‘Oh, she’s not for them.’ But I have a heart for homeless and mentally ill. Most of my family works with the mentally ill.” Noted a Chronicle journalist in 2017, “Inevitably, homeless advocates and others will say, ‘You’re not compassionate,’” in response to stories about homeless encampments. “They called me a racist,” said Tom. “They accused me, a guy who used to be homeless, of demonizing the homeless, because I’m asking for accountability.” I found myself similarly accused. In 2019, after I published an article for Forbes about the homeless crisis, a progressive homeless activist accused me on Twitter of having written my article to “make money off of a fear tactic” of “fueling hatred [and] even increasing violence against homeless people.” After I asked the former San Francisco supervisor for the Tenderloin neighborhood, former mayoral candidate Jane Kim, how such a progressive city ended up with so much suffering, she said, “My concern, Michael, just to be very honest, is that when that kind of messaging goes out, violence against people who are unhoused goes up.” […] I soon discovered in my research that I was hardly the first person that progressive elected officials and homelessness advocates had accused of fomenting violence against unhoused people. Many others had been criticized for far worse over the years, including San Francisco’s highest elected officials. “The criticism [by progressive homelessness advocates] was heavy, political and personal,” wrote former mayor Willie Brown in his 2008 memoir. “People accused me of abandoning the problem when I was working daily to try and get a solution going. It was brutal. . . . I had become demonized, and my own efforts belittled.” It is notable that the result of such personal attacks is to frighten off people seeking to change, and perhaps improve, the situation. “The problem” of homelessness, concluded Mayor Brown within nine months of entering office, “may not be solvable.” And [Quoting Chris Rufo]. “The chief of psychiatry in a public hospital system in one of the largest California cities told me, ‘I know for a fact, and all of my colleagues know, that what we actually need to deal with the problem in the biggest cities in California is long-term residential secure psychiatric care. But I can’t say that publicly because I would be disemboweled by the activist left. My job would be in jeopardy. My reputation would be in jeopardy. My whole life would get turned upside down for even broaching the subject of expanding secure mental health facilities and compulsory mental health treatment.’ And I said, ‘So what’s the solution?’ and this person said, ‘We muddle through.’” And: In San Francisco, radical left activists protested [African-American] Mayor London Breed in front of her home. Breed said the protesters were “all white people. But that didn’t bother me as much as the taunting of me coming outside with firework torches in their hands looking like what used to happen when the KKK would show up to black people’s houses to burn their houses down.” While I was reading the book, I came across this tweet, which suggests that being unimpressed with SF’s lefty homeless activist scene is not limited to Michael Shellenberger: Claim 9: European Cities Like Amsterdam Successfully Solved Their Own Drug And Homelessness Problems By Doing The Opposite Of SF Shellenberger bases his plan to solve these problems on ideas that he says were pioneered in Amsterdam and spread to other European cities. In the 1980s, Amsterdam had the kinds of problems San Francisco deals with now: open-air drug markets, overdose deaths, homelessness, and crime. But in the 90s, they admitted they had a problem and took decisive action: What’s the secret?” I asked him. “Amsterdam has decriminalized marijuana and many other drugs but I haven’t seen any homeless. What is San Francisco doing wrong?” Rene said that in the 1980s, the Zeedijk neighborhood in Amsterdam was a lot like the Tenderloin [the worst part of San Francisco] today. There was open-air drug use, particularly of heroin, and needles strewn about, as well as crime. People started to flee the neighborhood, worsening its slum conditions. Homeless people squatted in abandoned buildings. “We had ghettos where it was not safe to go,” said Rene, who started working in the neighborhood as a nurse in 1985. It was considered a “no go” zone. “We had a lot of people from abroad who came to Amsterdam because our heroin was so good. But our heroin was so good that they died from it.” At first the city tried a “helping approach” exclusively, offering addicts clean needles, methadone, and other forms of help without any law enforcement, but it didn’t work. “In the eighties we just wanted to help people,” said Rene. “We started with methadone programs and medical treatment. We did a lot of work without much of a carrot and a stick. It was really a disappointment. They just used the methadone to stay addicted. They dealt drugs and committed other crimes. They lied and cheated about it. We were just supporting a different kind of market. We had to learn the hard way [...] The Amsterdam City Council asked the Amsterdam Municipal Health Service to develop a strategy to deal with “unmotivated drug users”...The police broke up the open-air drug scene and health workers were on hand to offer methadone, treatment, and shelter. The police broke up gatherings of more than four or five users, but did not treat personal and private use as a crime. Officers ticketed violators, and if users did not pay their fines, which was frequent, the courts ordered arrests, and sentenced individuals to follow a treatment plan or face incarceration. “For every individual homeless person, we make a plan,” said Rene. “We made tens of thousands of those plans.” Plans are overseen by a caseworker and a team that may include a psychiatrist, shelter provider, service provider, judge, employer, parole officer, and police officer. “You need people in the police and health department working together,” he said. What Amsterdam did was the same as other major European cities. Lisbon, Frankfurt, Vienna, and Zurich all dealt with their open-air drug markets, using a combination of law enforcement and social services. Crucially, Amsterdam and other European cities prevented services from being concentrated in a single neighborhood, since their concentration often enables an open-air drug scene to thrive [...] The efforts worked. “We had several thousand people who were addicted to heroin in the eighties and nineties,” said Rene. “Many died. Today we have four or five hundred people addicted to methadone. And we have about 120 in Amsterdam who we supply heroin to on a medical basis because methadone doesn’t work for them. They have to use heroin.” The Amsterdam strategy goes something like: Break up open-air drug markets and anywhere that more than 4-5 drug users are congregating. Yes, people can just use their drugs in private, but this is legitimately better. Open-air markets normalize drugs with their blatantness, and make it hard to quit for the same reason it’s hard to diet if your partner leaves boxes of donuts out in the house every day.
Inline links: a proper randomized study, Somers, Moniruzzaman and Palepu, Padgett et al, Kirst et al, Milby, a $14 billion budget, This article, talk about, another article about people objecting to, boarding houses, Politico, has completed only 700 units, Considerations On Cost Disease, this comment, An article, https://substackcdn.com/image/fetch/$s_!4wi2!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F00f02bfe-c696-415d-ba80-5edb997021cb_809x487.png, survey, This app, this webpage, this site, many people, among the strongest proponents of both, these numbers, here, https://substackcdn.com/image/fetch/$s_!msoV!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F8b34d51f-d6ed-43ee-a069-5e74fe75c421_1812x1102.png, an anti-drug Australian think tank, https://substackcdn.com/image/fetch/$s_!CN2E!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F85656c06-22bc-4076-80f0-b7a9bd4aa0d3_574x331.png, A Resounding Success Or Disastrous Failure: Re-examining The Interpretation Of Evidence On The Portuguese Decriminalisation Of Illicit Drugs, https://substackcdn.com/image/fetch/$s_!VvrE!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F2341944a-388d-4da9-9788-8474567b83fc_540x737.png, Ed West, Public Policy Institute, UCI criminologists, Applied Divinity Studies’ article, https://substackcdn.com/image/fetch/$s_!aTNC!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2Fa27aeb21-ed87-4e67-b82c-b3ceecee7082_500x238.png, here, Here’s the San Francisco subreddit’s response, https://substackcdn.com/image/fetch/$s_!_NL6!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2Fcf7dc478-45d3-487d-8c29-8bc7cdf182dd_2400x1500.png, LouB’s analysis here, This news article, only 2.3% of shoplifting cases result in an arrest, New York Times, the Economist, https://substackcdn.com/image/fetch/$s_!58I3!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2Fc63dc7bc-1f8e-49fd-9c68-61c85278d69e_608x662.png, San Francisco’s ‘Crime Wave’ Is Just One Crime, https://substackcdn.com/image/fetch/$s_!h17s!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F956c0917-2a9b-4ff7-a08e-6aee5030583a_590x376.png, https://substackcdn.com/image/fetch/$s_!TkFS!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F5c5faa01-ac22-48a2-96fe-47efb6f52514_616x334.png, source, https://substackcdn.com/image/fetch/$s_!Bg2w!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F18e49c63-16ba-4878-96e6-aec12d7c5953_481x667.png, percent African-American, percent Borderer, here, the Twinkie Defense, https://substackcdn.com/image/fetch/$s_!8wK3!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F683b9754-f663-47ad-88f5-aa99bc208ec8_1401x622.jpeg, https://twitter.com/weheartprez/status/1526983899309432832
psilocybin microdosing1 mentions across 1 issues

psilocybin microdosing is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between May 17, 2022 and May 17, 2022. The archive places it in contexts such as "I’m especially concerned by psilocybin microdosing, which ranked 8th of almost 150 interventions". It most often appears alongside kanna, SAMe, SAMe.

Reference entry
psilocybin microdosing
Mention count
1
Issue count
1
First seen
May 17, 2022
Last seen
May 17, 2022
Outbound links
Issue trail
Related pages
Source context
Link: Troof On Nootropics
May 17, 2022 · Original source
I’m especially concerned by psilocybin microdosing, which ranked 8th of almost 150 interventions. Several double-blind studies have now shown this doesn’t work (eg). Worse, in unblinded studies, it seems to “work” best for the people who most strongly believe it will work, and seems to have whatever effect these people believe it will have. This is most likely a very exciting-sounding intervention that doesn’t work at all, and it was one of the very highest-rated on this survey. Meanwhile, SAMe, which has been shown to work well in RCT after RCT, is one of the lowest-rated.
Inline links: eg, it seems to
psoriosis1 mentions across 1 issues

psoriosis is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between April 03, 2023 and April 03, 2023. The archive places it in contexts such as "my son's psoriosis". It most often appears alongside 2008 Act, ACX, Adderall.

Reference entry
psoriosis
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1
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Highlights From The Comments On Telemedicine Regulations
April 03, 2023 · Original source
Telemedicine for an earache or my son's psoriosis -- okay. An antibiotic, some cream for his outbreaks. Fine. But I've done telemed a few times since covid and it is not like seeing a doctor in person. Yeah, the antibiotic -- on the third call -- fixed my sinus infection, but my swollen knee -- well, no. Doc gave me a prescription for painkillers and a steroid based on my camera angle. It didn't fix it. But I didn't take the painkillers, because I know they're addictive (and they generally make me puke). I asked for a referral to a physical therapist to actually fix my knee. "After you've done this for a while. In the meantime, put your feet up" and get out of shape and make the problem worse. Fortunately, I rain into a friend who is a PT and she gave me "advice" that included going to the gym and getting my knee back in shape. I stopped taking the steriod. I'll report to the doctor when I go for my annual -- IF I go for my annual because telemed isn't really medical care.
Psych 1011 mentions across 1 issues

Psych 101 is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between December 27, 2022 and December 27, 2022. The archive places it in contexts such as "The real studies by professional scientists usually use Psych 101 students"; "Get a bunch of Psych 101 undergrads, test their IQs". It most often appears alongside Aella, Gallup, Melinda Hauptmann-Brown.

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Psych 101
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December 27, 2022
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December 27, 2022
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Selection Bias Is A Fact Of Life, Not An Excuse For Rejecting Internet Surveys
December 27, 2022 · Original source
The real studies by professional scientists usually use Psych 101 students at the professional scientists’ university. Or sometimes they will put up a flyer on a bulletin board in town, saying “Earn $10 By Participating In A Study!” in which case their population will be selected for people who want $10 (poor people, bored people, etc). Sometimes the scientists will get really into cross-cultural research, and retest their hypothesis on various primitive tribes - in which case their population will be selected for the primitive tribes that don’t murder scientists who try to study them. As far as I know, nobody in history has ever done a psychology study on a truly representative sample of the world population.
Selection bias is disastrous if you’re trying to do something like a poll or census. That is, if you want to know “What percent of Americans own smartphones?” then any selection at all limits your result. The percent of Psych 101 undergrads who own smartphones is different from the percent of poor people who want $10 who own smartphones, and both are different from the percent of Americans who own smartphones. The same is potentially true about “how many people oppose abortion?” or “what percent of people are color blind?” or anything else trying to find out how common something is in the population. The only good ways to do this are a) use a giant government dataset that literally includes everyone, b) hire a polling company like Gallup which has tried really hard to get a panel that includes the exact right number of Hispanic people and elderly people and homeless people and every other demographic, c) do a lot of statistical adjustments and pray.
Selection bias is fine-ish if you’re trying to do something like test a correlation. Does eating bananas make people smarter because something something potassium? Get a bunch of Psych 101 undergrads, test their IQs, and ask them how many bananas they eat per day (obviously there are many other problems with this study, like establishing causation - let’s ignore those for now). If you find that people who eat more bananas have higher IQ, then fine, that’s a finding. If you’re right about the mechanism (something something potassium), then probably it should generalize to groups other than Psych 101 undergrads. It might not! But it’s okay to publish a paper saying “Study Finds Eating Bananas Raises IQ” with a little asterisk at the bottom saying “like every study ever done, we only tested this in a specific population rather than everyone in the world, and for all we know maybe it isn’t true in other populations, whatever.” If there’s some reason why Psych 101 undergrads are a particularly bad population to test this in, and any other population is better, then you should use a different population. Otherwise, choose your poison.
psychedelia1 mentions across 1 issues

psychedelia is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between August 26, 2025 and August 26, 2025. The archive places it in contexts such as "they understand human agency / scientific materialism / psychedelia". It most often appears alongside 4chan, ACX Grants, AI.

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psychedelia
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August 26, 2025
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August 26, 2025
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In Search Of AI Psychosis
August 26, 2025 · Original source
First, much like LLMs, lots of people don’t really have world models. They believe what their friends believe, or what has good epistemic vibes. If they don’t currently think that Lenin was a mushroom, it’s not because they understand human agency / scientific materialism / psychedelia and have a well-worked out theory of why fungi can’t contain sentient mushroom spirits that possess leading communist politicians. They don’t believe it because it feels absurd. They predict that other people would laugh at them if they said it. If they get told that it it’s not absurd, or that maybe people would laugh at them if they didn’t say it, then their opinion will at least teeter precariously.
psychiatrist1 mentions across 1 issues

psychiatrist is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between September 02, 2021 and September 02, 2021. The archive places it in contexts such as "Also, as a psychiatrist, I’m very against this conclusion". It most often appears alongside 1DaySooner, AC&E, AcesoUnderGlass.

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psychiatrist
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1
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1
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September 02, 2021
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September 02, 2021
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Long COVID: Much More Than You Wanted To Know
September 02, 2021 · Original source
This is terrible. Recovery rates in the single digit percentages over the space of years. You would think at least some patients would get placebo recoveries, or forget how it felt to be well, or otherwise Lizardman themselves into fake complacency, but no. This is f@#$ing awful. Maybe COVID won’t be this bad? One ray of hope comes from this Australian study, where doctors record the rates of recovery from postviral fatigue after various rare diseases they encounter (Epstein-Barr, Q fever, Ross River virus). They find that 35% of these patients have postviral fatigue after six weeks, but only 12% after six months, and 9% after twelve months. This sounds a lot better than chronic fatigue. In fact, these people do the kind of weird task of figuring out how bad different diagnostic labels for fatigue are, even though some might argue that all the labels refer to the same underlying reality. They find an official diagnosis of “CFS/ME” (chronic fatigue / myalgic encephalitis) is much worse than “postviral fatigue”. Using the weird measure of “days per year of followup with diagnosis” (I’m not sure I fully understand their reasoning for why this is good), they find a median length of 80 for CFS/ME vs. 0 for PVF (…huh?). Using the more comprehensible measure of percent who still complain of fatigue after 7-12 months, they find it’s 24% vs. 10% (which super contradicts the above study saying that basically nobody with a CFS/ME diagnosis ever recovers). My guess is that this study had much lower criteria for a CFS/ME diagnosis (some doctor diagnosed it and put it on the insurance records) compared to the ones above (some specialist confirmed it by official criteria). The conclusion I draw is that, while official CFS/ME is horrible and hopeless, there are a lot of things that unofficially look kind of chronic-fatigue-ish which have pretty good prognoses. Since there’s no good reason to think post-COVID fatigue is official CFS/ME as opposed to just some chronic-ish fatigue-ish thing, probably it will have a better prognosis, more like weird Australian viruses. …which we still don’t know, because AFAICT nobody has done any good studies on postviral fatigue lasting more than a year. 5. Psychosomatic symptoms probably aren’t the majority of long COVID. I mean, I’m not seeing too many people claiming that they are. There are a lot more people worried that someone else might be claiming that, than people actually making the claim. Still, the Wall Street Journal opinion section is always up for slathering itself in glue and rolling around in a haystack until it becomes the straw man everyone else warned you about, and they do have an article on The Dubious Origins Of Long COVID. They point out that long COVID was first thrust into the public consciousness in surveys run by Body Politic, who self-describe as “a queer feminist wellness collective merging the personal and the political”. I agree this is a weird source for something to come from, but Hans Asperger was a Nazi and I still use his diagnosis, so I probably have to accept these people’s as well. More relevantly, WSJ points out that many of the people complaining of Long COVID symptoms test negative for COVID, or at least never tested positive. This complaint conflates the fact that not everyone was able to get a COVID test at all, with the fact that sometimes you get the acute COVID test after you’ve recovered from acute COVID and it’s negative, with the fact that COVID tests don’t have a 100% success rate, with the fact that yeah, okay, some people who didn’t have COVID are probably imagining Long COVID symptoms. I feel like some of the case-control studies above, which clearly show that seropositive people have higher rates of Long COVID than seronegative people, are pretty convincing here. But also - the people with lung scarring clearly have lung scarring, and most of them have weird x-rays consistent with lung scarring. If you have lung scarring, then you have trouble breathing, you’re fatigued, and you probably have lots of other stuff downstream of that. The people with smell/taste disturbances clearly have smell/taste disturbances, testable with the stupidly named but scientifically venerable Sniffin Sticks test - and also, who even cares enough to make up olfactory problems? Fatigue and brain fog are the only symptoms here that can’t be easily objectively confirmed, and, well, do you think those Australians who got infected with Q fever and had twelve months of postviral fatigue are faking? What about all those post-Epstein Barr fatigue people? Lots of viruses cause postviral fatigue, it’s not really surprising that COVID should also. (WSJ also spends a while arguing that CFS/ME is just a psychiatric disorder, which I think is not really in keeping with the best recent evidence. Also, as a psychiatrist, I’m very against this conclusion, mostly because if it were true, then people would expect me to cure CFS/ME patients.) One point WSJ didn’t bring up but could have was that most Long COVID patients are women. Probably this is somewhere between 60 and 80% - I suspect on the lower end of this, because I think women are more likely to talk about these kinds of things than men, and much more likely to eg join Facebook groups. This is noteworthy, because women are traditionally more prone to psychosomatic illnesses - so much that the ancients attributed these to the uterus and called them hysteria (note shared root with eg “hysterectomy”). Women are about 2x as likely to get diagnosed with panic disorder, anxiety disorders, phobias, etc, about 2.5x as likely to get chronic Lyme disease, widely regarded as an entirely psychosomatic condition, and 3-5x more likely to be diagnosed with fibromyalgia. So the female preponderance is suspicious. But women are also somewhere between 2x and 4x more likely to get autoimmune disorders than men (it varies by disorder - the ratio for Sjogren’s is as high as 16x). There are some pretty crazy hypotheses for why this is - for example, maybe women’s immune systems are permanently upregulated to be prepared for attempts by the placenta to secrete immune-downregulating chemicals during pregnancy, as part of the creepy shadow war between mother and fetus to regulate the maternal environment. I don’t know, do you have a better idea? Anyway, women have more autoimmune issues and more upregulated immune systems, so if there was any good way to assess gender ratio in true postviral fatigue excluding all psychosomatic cases, that would probably be female-biased too. Probably some Long COVID cases are psychosomatic just like some cases of anything are psychosomatic, but I don’t see too many signs that this is too important in explaining the phenomenon. …and please allow me a moment of preachiness here. Chronic fatigue sounds really fake to anyone who doesn’t have it. I think this is because it’s related to willpower. Willpower itself would sound fake to anyone who didn’t have to worry about it. “Oh, so you can go partying with your friends whenever you want, but as soon as it comes time to write a ten page report, your ‘lack of willpower’ prevents you from doing it? A likely story!” Still, all of us (except Bryan Caplan) recognize how real and important willpower is - how having more of it is better than having less of it, and how some condition that caused you to have pathologically little of it would be a huge disaster. In the comments section to the rough draft of this post, CJ wrote: I will say - I was one of those types of men to scoff with skepticism at people claiming to have chronic fatigue and the like. I would have called those people lazy and would have been adamant they were faking it or feeling like crap because of unhealthy lifestyle choices. Unfortunately I have learned the hard way the severity of neurological conditions, what it feels like to have brain fog, what chronic fatigue feels like, and how difficult it can be to communicate neurological symptoms to others. I now start from a position of listening to people who are willing to open up about their symptoms and trust that they are being honest. There are millions of people suffering in silence with untreated and undiagnosed disorders - those people are not all faking it or just dealing with psychosomatic conditions. I would recommend Jennifer Brea's documentary, Unrest. Thank you for shedding some light on the subject. Heron added: I second the suggestion to watch 'Unrest,' and to consider the many unseen ill whose symptoms are deemed to be imagined. Until this last year, I had little patience with, and doubted, people who I saw as hypochondriacs. Then I became the thing I hated. Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Long COVID do have similarities from what I've read, since becoming ill in August 2020. At that time, here in Northern Ireland, there was scant availability of COVID tests; after spending three days trying to get hold of one, (by which time I'd stopped teaching my post-grad online classes & I haven't worked since) I became too ill to do anything. I figured if this was COVID I'd gotten off lightly, mostly constant severe headache, inability to think, a new experience of fatigue, high temperature, insomnia, hypersomnia, paresthesia, no smell or taste etc Debilitated but not dead. Except for the fact that I still have the aforementioned symptoms a year on and whilst they fluctuate in type and severity, the fatigue, headaches and cognitive difficulties are real. A brain scan, an appointment for brain and spinal MRIs (waiting lists, even when going private [as NHS has 3-8 yr waiting lists here in NI] are lengthy), rare virtual doctors and neurologists suggest my ailments constitute a post-viral thing, maybe Long C, they can offer nothing but pills for pain. There is no test for ME/CFS yet, nor a Long C test, symptoms and presentation are so varied. Given a widespread lack of knowledge and resources regarding these ailments, you're on your own. Maybe I've developed ME, I certainly have post-exertional malaise which my very prominent neurologist hadn't heard of. Looking at the history of ME/CFS* and a dearth of research surrounding it, I hope that rather than dismiss the lives of sufferers of this or the long-lasting aftermath of COVID, that those experiencing such difficulties will be heard and learnt from. I only understood when I had no alternative. I don’t think I ever actively pooh-poohed CFS, but like everyone else who encountered it, I underestimated just how bad it was until I met some patients with the condition. It is real and really bad. For whatever reason it is hard to think about and take seriously, but it really is as bad as people say. </preachiness> 6. Long COVID is probably rare in children This matters a lot, because children are (currently) ineligible for the vaccine, and also likely to encounter the virus at school. But children usually have mild cases of COVID and don’t die from it, so it’s tempting to just not worry about them. But if they could get Long COVID, that would make it much less tempting. Preliminary Evidence On Long COVID In Children sounds like a good paper to draw conclusions from. It says 42.6% of children with COVID experience long-term follow-up symptoms, which would be higher than the rate for adults. But it has no control group, and most of the symptoms it finds don’t seem very COVID-related (eg rashes, constipation). The most common symptom (20%) is insomnia, which better studies in adults fail to associate with real Long COVID. The rate of known long COVID symptoms (eg taste and smell problems) is only about 3-4%, and no higher or lower than anything else. Probably these kids are just having problems at the usual rate and attributing them to their recent COVID. Blankenburg et al do the correct thing and ask a thousand children about potential symptoms, then compare the number who say yes vs. no among COVID-seropositive and seronegative subjects. They find no difference between the two groups. Both are reporting a lot of insomnia, etc. They reasonably attribute this to pandemics being a stressful event that it’s natural to lose sleep over. This is really reassuring, but it can’t rule out a somewhat rarer syndrome. The authors say that they might miss symptoms with a prevalence of less than 10%, and one of them gives his own personal guess that it’s 1%. An English team says there’s a Long COVID rate of 4.6% in kids. But there was a 1.7% rate of similar symptoms in the control group of kids who didn’t have COVID, so I think it would be fair to subtract that and end up with 2.9%. And even though the study started with 5000 children, so few of them got COVID, and so few of those got long COVID, that the 2.9% turns out to be about five kids. I don’t really want to update too much based on five kids, especially given the risk of recall bias (ie you might notice / care about your symptoms more if you know you had COVID before getting them). My overall conclusion here is that long COVID is rarer in children than adults, and may not exist at all. The studies tell us it’s probably somewhere less than 5% of kids, but so far we can’t conclude anything stronger than that. 7. Vaccination probably doesn’t change the per-symptomatic-case risk of Long COVID much Here’s a complicated Twitter thread about this. Of vaccinated people who got symptomatic COVID, about a third ended up with Long COVID symptoms, the same rate as in unvaccinated people. Of course, vaccinated people are much less likely to get symptomatic COVID. But even conditional on getting it, they’re still much less likely to go to the hospital, die, etc. It would have been nice if the same was true of getting Long COVID. But it doesn’t look that way. (all this information is from an online poll by a sketchy group of COVID “survivor” activists. But they wrote up their poll in the scientific paper font, as a PDF and everything, so I say we count it anyway) This NEJM study wasn’t exactly designed to look for Long COVID in vaccinated people. But they found it anyway, at a rate of 19% after 6 weeks. This also fits within the (wide) range reported for unvaccinated people. They don’t give a symptom breakdown beyond “prolonged loss of smell, persistent cough, fatigue, weakness, dyspnea, or myalgia”, which sounds like the usual set. These studies are pretty weak, and you could argue that given that vaccines decrease the average severity of COVID infection, and infection severity is linked to Long COVID risk, we should have a strong prior on vaccines decreasing Long COVID risk. And just before publishing this, someone sent me this study, which very preliminarily finds vaccines might decrease Long COVID risk by a factor of 2. I think a factor of 2-3 is believable; one of 10 or 20, less so. Weirdly, there are some claims that vaccines can help relieve symptoms of existing long COVID. Sounds kind of like sympathetic magic to me, but the researcher quoted in the linked article said it might “improve symptoms by eliminating any virus or viral remnants left in the body” or by “rebalancing the immune system”. So yeah, sympathetic magic. 8. Your risk of a terrible long COVID outcome conditional on COVID is probably between a few tenths of a percent and a few percent. My original calculation went like this: About 25% of people who get COVID report long COVID symptoms. About half of those go away after a few months, so 12.5% get persistent symptoms. Suppose that half of those cases (totally made-up number) are very mild and not worth worrying about. Then 6.25% of people who get COVID would have serious long-lasting Long COVID symptoms. After doing that calculation, I read this essay by Matt Bell, who tries to figure out the same thing. He is much more optimistic. He agrees that about half of long COVID cases go away after a few months, but adds another 50% decrease from “few months” to “lifelong”, kind of on priors, admitting there’s not too much positive evidence for this. Then he adds another factor-of-two decrease from vaccination, based on very preliminary studies from the UK. He estimates that someone with my demographics (vaccinated man in his 30s) has a 2% risk of Long COVID conditional on getting COVID at all. Then he divides by five for the true worst case scenario, based on studies showing that a fifth of people with Long COVID report that it affects their daily activities “a lot”. So by his final number, I have an 0.4% chance of getting really terrible long COVID, conditional on getting COVID at all. My friend AcesoUnderGlass also did a writeup of this, published after I did my first-draft calculation, which seems to be thinking of this very differently, based entirely on hospitalization rates (which of course are very low in vaccinated people our age). She accordingly concludes that risk is very low. I don’t really understand her reasoning here, but I trust her a lot and am working on trying to converge with her on this. What’s my yearly risk of getting COVID if I try to live a normal life? This site says only 0.1% of vaccinated Californians have gotten COVID after their vaccination. But vaccination was pretty new when that survey was done, so we might want to take this as a per one-to-two-months estimate. That would mean a risk of 0.5 - 1 percent per year. But not all these people are living normal lives, so my risk might be higher. MicroCOVID gives me a good sense of how careful I’d have to be to stay within a risk budget of 1% COVID risk per year. When I play around with it, I think I am about 5x - 10x less careful than that, which would mean a risk of about 5%/year. This tracker suggests my area has recently had about 1 new case per thousand people per week, which would imply 5% per year. But most of those people are probably unvaccinated, so my risk would be significantly lower than that. I’m going to round all of this off to about 1% - 10% per year of getting a breakthrough COVID case (though obviously this could change if the national picture got better or worse). Combined with the 0.4% to 6.25% risk of getting terrible long COVID conditional on getting COVID, that’s between a 1/150 - 1/25,000 chance of terrible long COVID per year. How does this compare to other risks? My ordinary risk of death per year, just from being a man in his 30s, is about 1/700 (though this includes drug abusers and stunt pilots, so my real risk might be lower, let’s say 1/1000). Here are some other risks, courtesy of the BMJ: In this context, I find the 1/150 risk pretty scary and the 1/25,000 risk not scary at all, so, darn, I guess there’s not yet enough data to have a strong sense of how concerned I should be. 9. This is hard to compare to other postviral syndromes Going into this, I wondered if we might be able to ignore Long COVID. The argument would go like this: all viral diseases have a risk of postviral syndromes. Colds, flus, mono, lots of stuff that’s going around all the time. Lots of people get those postviral syndromes, and either recover or don’t, but either way we don’t make a big deal out of it. Since COVID’s considered “newsworthy” in a way flu isn’t, we obsess over its postviral syndrome even though it’s no worse than anything else’s. This wouldn’t make Long COVID any less bad, and maybe we would be wrong to not panic more about colds and the flu, but it would at least give us some context and make things feel less scary. Unfortunately, I can’t find anything supporting or opposing this picture. The only relevant study is a meta-analysis by Poole-Wright et al, who (contra nominative determinism) don’t pool the studies by condition, which makes it hard to draw conclusions. I think all of their examples of postviral syndrome after flu are from severe hospitalized cases, so any comparison with COVID would be unfair. Although there do seem to be scattered reports of post-flu problems, they’ve never been formally studied or quantified. Mononucleosis is an infectious disease caused by the Epstein-Barr virus, affecting about 1/2000 people per year in developed countries. It has a famously nasty postviral syndrome, which this paper describes as “almost one-half of the group had substantial ongoing symptoms 2 months after onset and… ∼10% had disabling symptoms marked by fatigue lasting ≥ 6 months”. Flu is as common as COVID, but nobody really talks about it having a significant postviral syndrome so probably it’s not that bad. Mono has a worse postviral syndrome than COVID, but it’s rare enough that it doesn’t cause massive society-wide effects. COVID is right in the middle: more common than mono, and (probably) worse postviral syndrome than flu. I think it’s fair to say that we may not have encountered a condition with this exact combination of risk factors and can’t dismiss it as similar to conditions we currently ignore. One potential analogue might be the Spanish Flu of 1918. It was an equally widespread pandemic, and seemed to have some kind of postviral syndrome. From TIME: In what is now Tanzania, to the north, post-viral syndrome has been blamed for triggering the worst famine in a century—the so-called “famine of corms”—after debilitating lethargy prevented flu survivors from planting when the rains came at the end of 1918. “Agriculture suffered particular disruption because, not only did the epidemic coincide with the planting season in some parts of the country, but in others it came at the time for harvesting and sheep-shearing.” Kathleen Brant, who lived on a farm in Taranaki, New Zealand, told Rice, the historian, about the “legion” problems farmers in her district encountered following the pandemic, even though all patients survived: “The effects of loss of production were felt for a long time.” The 1918 flu seemed to have lots of psychiatric effects: “Norwegian demographer Svenn-Erik Mamelund provided such evidence when he combed the records of psychiatric institutions in his country to show that the average number of admissions showed a seven-fold increase in each of the six years following the pandemic, compared to earlier, non-pandemic years.” Coronavirus doesn’t - the excellent Amin-Chowdhury study above finds nothing. Still, this is the scale of thing I’m worried about. The worst case scenario here is really really bad. If a few percent of COVID patients get long-term unremitting genuine CFS/ME, that has the potential to overwhelm government welfare budgets and long-term depress the economy. I think there’s a 90% chance the real situation isn’t that bad, but it’s scary that we can’t entirely rule it out. Aside from the somewhat different 1918 case, I don’t think we have any historical experience of dealing with postviral syndromes at this scale. The medium case scenario is something more like “a few percent of infected people get moderate fatigue, which doesn’t really prevent them from working, and goes away after a few years”. I don’t know whether the level of media attention paid to this would converge on “boring and nobody notices” or “giant disaster”, and I think it would be compatible with either. 10. Conclusions 1. Long COVID is many different issues without a common mechanism. 2. Some of these are straightforward and not surprising, eg lung scarring and post-ICU syndrome from severe infection, and would happen in any disease of this severity. Others seem to be more like the poorly-understood postviral syndromes associated with several other diseases. While some symptoms may be psychosomatic, most are probably organic. 3 The three major categories of symptoms are straightforward cardiovascular-pulmonary issues, straightforward smell and taste issues, and more mysterious neurological issues. 4 Although these get better with time in some people, in a significant number (maybe ~50% of people who had them at six weeks) they persist for as long as anyone has been able to measure them (a few months in the case of COVID, a year or two in the case of comparable syndromes). 5. Post-COVID fatigue is particularly concerning. This would be very bad if we analogized it to CFS/ME, and still pretty bad if we analogized it to other known postviral syndromes. There is no proof that this always gets better over the long term, although no study has looked at them for more than a few years. Facing postviral fatigue on this scale is a new problem. 6 . Children probably get Long COVID less than adults, probably at a rate of less than 5% of symptomatic cases. But we don’t know how much less, and we can’t rule out that some children get pretty severe symptoms. 7. Although vaccination decreases the risk of symptomatic COVID, it probably doesn’t decrease the risk of Long COVID per symptomatic COVID case by very much, though it might decrease it by a factor of 2-3. 8. Your chance of really bad debilitating lifelong Long COVID, conditional on getting COVID, is probably somewhere between a few tenths of a percent, and a few percent. Your chance per year of getting it by living a normal lifestyle depends on what you consider a normal lifestyle and on the future course of the pandemic. For me, under reasonable assumptions, it’s probably well below one percent. EDIT: Here are some other people who tried to do this same analysis. I learned about all of these after I wrote the first draft of this, so you can consider the basic thought process here to be independent of them - but I edited some things to account for what I learned from them before writing the final version. AcesoUnderGlass: Long COVID Is Not Necessarily Your Biggest Problem
Inline links: Lizardman, this Australian study, these people, The Dubious Origins Of Long COVID, weird x-rays, Sniffin Sticks test, somewhere between 60 and 80%, somewhere between 2x and 4x more likely, for example, the creepy shadow war between mother and fetus, Bryan Caplan, wrote, added, Preliminary Evidence On Long COVID In Children, Blankenburg et al, one of them, English team says, Here’s, the scientific paper font, This NEJM study, infection severity is linked to Long COVID risk, this study, vaccines can help relieve symptoms of existing long COVID, this essay, a writeup of this, This site says, MicroCOVID, This tracker, the BMJ, https://substackcdn.com/image/fetch/$s_!yL40!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F1eea7cfa-df08-4c67-acf2-da24ce860ae3_713x373.png, a meta-analysis by Poole-Wright et al, scattered reports, this paper, postviral syndrome
psychic phenomena1 mentions across 1 issues

psychic phenomena is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between November 28, 2021 and November 28, 2021. The archive places it in contexts such as "all of which prove psychic phenomena exist". It most often appears alongside Abba Eban, ACX, Albert Einstein.

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psychic phenomena
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1
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1
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November 28, 2021
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November 28, 2021
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Open Thread 200
November 28, 2021 · Original source
But as I’ve tried to point out elsewhere, adding more studies can only address problems within your model, not problems outside your model. Suppose that some parapsychologist has done twenty studies, all of which prove psychic phenomena exist (and there are many such parapsychologists!) Does it help if she works for another year or two, and we get forty such studies? How about another decade, and we get two hundred such studies? Who cares?! We already know that this parapsychologist, using whatever methodology she uses, is able to consistently get positive results. It’s not like all twenty of her studies went badly just by coincidence! So either you should believe in psychic phenomena, or you should believe that this genre of study is bad (ie an outside-of-model problem) and we need some independent researcher or some better methodology to try replicating it.
I realize this looks bad - aren’t we supposed to use “replications” and “number of studies” as a proxy for truth? But this is why I point out that there are dozens of studies showing psychic phenomena are real, and hundreds of studies showing the same for homeopathy. I don’t think anyone has a great idea where to go from here (“larger and more professional studies” is a good guess, but people will understandably worry that just means the establishment wants to never have to admit it’s wrong and wants only establishment studies that it can bias to count). But “just do the same bad studies more and more times” sure isn’t the answer.
psychic powers1 mentions across 1 issues

psychic powers is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between May 30, 2025 and May 30, 2025. The archive places it in contexts such as "looking closely into the evidence for psychic powers". It most often appears alongside 3Blue1Brown, Aella, Alasdair MacIntyre.

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psychic powers
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1
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1
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May 30, 2025
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May 30, 2025
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Bayes For Everyone
May 30, 2025 · Original source
Taking this seriously is how I came up with a set of online summer camps. The weeklong course last year used Bigfoot to get kids to experience using Bayes theorem. The one from this summer will deepen that by looking at claims of sea monsters. Year 3’s will extend this, asking when we should trust the media on UFOs UAPs. Year 4’s will hold a bright light up to academic, peer-reviewed sources by looking closely into the evidence for psychic powers, and year 5’s will try to suss out the edges of science itself by looking into the evidence for ghosts. Whatever else these summer camps accomplish, I hope they’ll prepare my students for whatever dubious assertions they run across on YouTube.
Inline links: a set of online summer camps
psychoanalytic literature1 mentions across 1 issues

psychoanalytic literature is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between February 16, 2022 and February 16, 2022. The archive places it in contexts such as "drawing on ... psychoanalytic literature". It most often appears alongside Abercrombie & Fitch, Athenian democracy, Athenians.

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February 16, 2022
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Book Review: Sadly, Porn
February 16, 2022 · Original source
He’s also impressively erudite, drawing on the Greek and Latin classics, the Bible, psychoanalytic literature, and all of modern movies and pop culture. Sometimes you read the scholars of two hundred years ago and think “they just don’t make those kinds of guys anymore”. They do and Teach is one of them.
psychodrama1 mentions across 1 issues

psychodrama is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between October 30, 2024 and October 30, 2024. The archive places it in contexts such as "all those guys are part of your psychodrama". It most often appears alongside 1984, Abandon Harris, Acemoglu.

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psychodrama
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October 30, 2024
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October 30, 2024
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ACX Endorses Harris, Oliver, Or Stein
October 30, 2024 · Original source
I might criticize their strategy in more depth in another post, but I won’t deny it makes a certain kind of perverse sense. More than that though, something here resonates with me psychologically. I keep having to shake myself out of viewing this election as a psychodrama with two characters: myself and the Democratic Party.
When you're in that state of mind, you end up like those Muslims in Michigan. Your world narrows to a two-character psychodrama between yourself and the Democrats. In this psychodrama, the Republican Party is an offscreen character, mentioned but never seen. It fills the same role as Emmanuel Goldstein in 1984: a formless target representing either everything you hate or everything you hope for, depending on how the psychodrama goes. Nobody knew Emmanuel Goldstein's position on tax rates, and it would be insane to ask.
A long time ago, I wrote about the difference between ingroup, outgroup, and fargroup. Ingroup and outgroup you know. But how come people have stronger emotions about Ibram X. Kendi (or Chris Rufo) than about Kim Jong-un or whoever's committing the latest genocide in Sudan? It's not because you're American and naturally care about American affairs - how about that Brazilian judge who banned Elon Musk's X? It's because all those guys are part of your psychodrama and some Sudanese psychopath isn't. Well, Kamala Harris' price controls are my outgroup; Donald Trump setting tariffs is my fargroup.
Inline links: the difference between ingroup, outgroup, and fargroup
psychological hedonism1 mentions across 1 issues

psychological hedonism is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between May 15, 2024 and May 15, 2024. The archive places it in contexts such as "only a watered-down version of psychological hedonism is needed". It most often appears alongside @the_megabase, A Pan-Species Welfare State, ACX Grantees.

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psychological hedonism
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May 15, 2024
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Profile: The Far Out Initiative
May 15, 2024 · Original source
Recalibrating our hedonic set-point doesn't - or at least needn't - undermine critical discernment. All that's needed for the abolitionist project and its hedonistic extensions to succeed is that our ethic isn't committed to perpetuating the biology of involuntary suffering. Likewise, only a watered-down version of psychological hedonism is needed to lend the scenario sociological credibility. We can retain as much - or as little - of our existing preference architecture as we please. You can continue to prefer Shakespeare to Mills-and-Boon, Mozart to Morrissey, Picasso to Jackson Pollock while living perpetually in Seventh Heaven or beyond.
psychological re-enactment1 mentions across 1 issues

psychological re-enactment is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between July 23, 2024 and July 23, 2024. The archive places it in contexts such as "It’s psychological re-enactment, plain and simple". It most often appears alongside Afghanistan, Akhenaten, Al Franken.

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July 23, 2024
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July 23, 2024
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Some Practical Considerations Before Descending Into An Orgy Of Vengeance
July 23, 2024 · Original source
Any rule of the form “Don’t do X, unless you can think up a big pile of negative adjectives to describe why the people you’re doing X to deserve it” will simply never prevent anyone from doing X, not even once. 5. Most Cancellations Are Friendly Fire Postcards From Barsoom helpfully includes a list of the cancellations he finds most enraging. I agree most of them are enraging. But they’re not stories about Trump, Tucker Carlson, or Nick Fuentes. The median victim of cancel culture is some center-left college professor who sent out an email saying that he supports BLM but questions some of their tactics. (I would add David Shor to the list as an especially revealing case, and Al Franken as an especially clear own-goal) This is because you mostly get the critical mass necessary for cancellation in very leftist institutions, and most people in very leftist institutions are leftists. There’s a deeper problem here where pre-emptive fear of cancellation blocked rightists from joining these institutions in the first place. But in terms of actual cancellations, they’re usually some poor shmuck who put too few exclamation points after “BLM!!!!” Likewise, if there are right-wing cancellation squads, they won’t cancel Rachel Maddow or Kamala Harris. They’ll get some WSJ writer who puts too few exclamation points after “MAGA!!!!” 6. Cancellation Is The Enemy Of Competence Cancellation isn’t just morally bad. It also screws over society. And it screws over your own institutions worst of all. By society I mean: you want scientists to be producing good science, not producing the science least likely to get them cancelled. You want the Federal Reserve filled with the best economists, not the most politically pure economists. No matter how righteous your cause, if you cancel people who don’t agree with it, you end up with the kind of low-quality science and corrupt institutions we’ve grown used to recently. This is bad insofar as you care about things like truth, trust, or national flourishing. But even if you don’t care about those things, remember that cancellation is mostly friendly fire. Cancellers can’t 100% control broader society, but they do control their own party and its organs. I think this is part of why the Democratic Party is floundering right now. At the risk of getting cancelled myself, it kind of seems like Democrats now wish they’d put a little more of thought into picking a popular/electable VP in 2020 instead of the most diversity-box-ticking person they could find on short notice. Why didn’t they? Well, would you, as a Democratic Party insider, want to speak out against Kamala Harris, in f**king 2020 of all years? Obviously anyone who tried that would have been cancelled. So nobody spoke out against the decision, they went ahead with it, and now they’ve boxed themselves into a corner. You, too, can one day have a party this self-sabotaging and incapable of winning elections! All you need to do is adopt cancel culture! (“But we would only apply it to actually bad things, not to people on our own side just trying to warn us”. I’m pretty sure the Democrats didn’t go into this expecting to punish people on their own side trying to warn them, yet here we are.) 7. No, Seriously, This Is A Terrible Decision I think the Democrats as a political party are massively underperforming their fundamentals. They have most of the elites (elites, by definition, are powerful), most of the donor money, and their two main bases (college graduates and minorities) have both ballooned as a share of the population, while the Republicans’ (white people, rural people) are in decline. They control all the prestige media. Trump has no self-control and dozens of skeletons in his closet. How could they lose? There are many factors - inflation, Afghanistan, the Electoral College - but part of the story has to be that wokeness and cancel culture are historically unpopular. They produced short-term gains (as people became afraid to speak out against them) but long-term disaster (as their extremism alienated friends and fired up enemies). This is still just my optimistic prediction. But if conservatives ever in fact take enough power that they can wield cancellation more effectively than the Democrats, then it will have been borne out. In which case, you, too, will have the opportunity for short-term gains at the expense of alienating everybody with a backbone and/or conscience. What could possibly go wrong? 8. Don’t Go Mad With Power Until You Actually Get The Power I can’t remember if this is on the Evil Overlord List, but it should be. The right is still out of power. For one thing, Biden is still President. There’s even (according to betting markets) a 40% chance that the Dems win the next election. (The argument in this paragraph isn’t original, but I lost the link to it): Consider an undecided voter in a swing state. As an independent, they’re probably on the right on some issues and on the left on others. Many of them are probably former liberals who left the fold because of wokeness and cancel culture. Now they check out what right-wingers have to offer, and it’s “We also love cancel culture, we plan to drop all of our principles as soon as we win, anyone with lefty opinions should be terrified.” Doesn’t sound like a great advertisement. But also: even if Trump wins in a landslide, conservatives still won’t control the levers of cancel culture. Did the Republicans taking the White House, House, and Senate in 2016 end cancel culture? Did it even slow it down? Plus or minus a few civil rights laws, cancel culture isn’t implemented at the government level. It’s implemented at the level of media, institutions, and popular taste-making, which Democrats hold more firmly than federal government. Even if Trump wins, the median outcome of conservatives endorsing cancellation is that the few liberals in these institutions trying to restrain their worst tendencies get dismissed as useful idiots for conservatives who wouldn’t hesitate to cancel them if they were on the other side. Why mention this? Because the people talking about cancellation insist they’re “just being strategic” and “just laser-focused on winning” when in fact writing the blog posts at all reveals they couldn’t care less about any of these considerations. It’s psychological re-enactment, plain and simple. 9. There’s Probably Other Options “But we can’t just do nothing!” Unfreedom of conscience, like famine and plague, has haunted us throughout history and will probably continue to do so. Still, I think the very-long-range trend for all three problems is down, and that hard work by good people can push that forward. This will look like boring incremental progress, ie the only thing that has ever worked. Here are some possible subtasks: Politicians should dismantle the government apparatus propping up cancel culture. Certainly the sorts of things mentioned in the Twitter Files count here, but so do some of the civil rights stuff Richard Hanania talks about in Origins of Woke.
Inline links: Postcards From Barsoom, David Shor, Al Franken, Evil Overlord List, psychological re-enactment, Twitter Files, Origins of Woke
psychology of religion1 mentions across 1 issues

psychology of religion is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between October 09, 2024 and October 09, 2024. The archive places it in contexts such as "academic degree in the psychology of religion". It most often appears alongside 16th of August, Bodhicaryāvatāra, CAT scan.

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psychology of religion
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October 09, 2024
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October 09, 2024
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Triple Tragedy And Thankful Theory
October 09, 2024 · Original source
Pattern match! A catastrophic realization comes crashing in. The necessary expertise has been available all along, from my academic degree in the psychology of religion. I did have seizures for years, I just didn’t realize it because of the misdiagnosis, and they came from my (right-side) temporal lobe. Temporal lobe epilepsy is strongly associated with mystical experiences, which I did have despite my atheist convictions, and with what is misleadingly termed “hyperreligiosity” but really means heightened interest in metaphysical questions: a temporal lobe epileptic can be an atheist who wants to talk to you for hours about why atheism is correct.
Inline links: mystical experiences
psychology professors1 mentions across 1 issues

psychology professors is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between May 28, 2021 and May 28, 2021. The archive places it in contexts such as "Some of them are psychology professors". It most often appears alongside A Game of Thrones, Africa, African Americans.

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psychology professors
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May 28, 2021
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May 28, 2021
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Your Book Review: Humankind
May 28, 2021 · Original source
There do exist terrible people who will work hard to get people to do terrible things to each other. Some of them are psychology professors.
psychometrics1 mentions across 1 issues

psychometrics is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between November 09, 2021 and November 09, 2021. The archive places it in contexts such as "Francis Galton invented the modern fields of psychometrics". It most often appears alongside Aage Bohr, Abanindranath Tagore, Aldous Huxley.

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psychometrics
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1
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November 09, 2021
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November 09, 2021
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Secrets Of The Great Families
November 09, 2021 · Original source
Charles Darwin discovered the theory of evolution. His grandfather Erasmus Darwin also groped towards some kind of proto-evolutionary theory, made contributions in botany and pathology, and founded the influential Lunar Society of scientists. His other grandfather Josiah Wedgwood was a pottery tycoon who "pioneered direct mail, money back guarantees, self-service, free delivery, buy one get one free, and illustrated catalogues" and became "one of the wealthiest entrepreneurs of the 18th century". Charles' cousin Francis Galton invented the modern fields of psychometrics, meteorology, eugenics, and statistics (including standard deviation, correlation, and regression). Charles' son Sir George Darwin, an astronomer, became president of the Royal Astronomical Society and another Royal Society fellow. Charles' other son Leonard Darwin, became a major in the army, a Member of Parliament, President of the Royal Geography Society, and a mentor and patron to Ronald Fisher, another pioneer of modern statistics. Charles' grandson Charles Galton Darwin invented the Darwin-Fowler method in statistics, the Darwin Curve in diffraction physics, Darwin drift in fluid dynamics, and was the director of the UK's National Physical Laboratory (and vaguely involved in the Manhattan Project).
Inline links: Charles Darwin, Erasmus Darwin, Josiah Wedgwood, Francis Galton, Sir George Darwin, Leonard Darwin, Charles Galton Darwin
psychoorganic syndrome1 mentions across 1 issues

psychoorganic syndrome is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between July 21, 2021 and July 21, 2021. The archive places it in contexts such as "state the diagnosis as "psychoorganic syndrome"". It most often appears alongside 9/11, ACOUP, Adderall.

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psychoorganic syndrome
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July 21, 2021
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July 21, 2021
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Highlights From The Comments On "Crazy Like Us"
July 21, 2021 · Original source
Living in Russia, I can say that ADHD (translated as СДВГ) is less recognized by the psychiatry community here because of its unclear aetiology. Doctors usually refuse to treat the patients in the absence of dangerous symptoms, and state the diagnosis as "organic nervous system disorder", "psychoorganic syndrome" or indeed "neurasthenia". Adderall and Ritalin are illegal drugs here. Patients usually get prescribed nootropics (glycine, racetams) and adrenaline reuptake inhibitors (atomoxetine).
Psychophysical harmony1 mentions across 1 issues

Psychophysical harmony is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between February 21, 2025 and February 21, 2025. The archive places it in contexts such as "Bulldog mentions consciousness, psychophysical harmony, and moral knowledge as proofs"; "hallucinating loose ends that don’t really exist so that you can bring Him in to solve even more things (eg psychophysical harmony, moral knowledge)". It most often appears alongside /r/slatestarcodex, ACX, Adrian.

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Psychophysical harmony
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February 21, 2025
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February 21, 2025
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Highlights From The Comments On Tegmark's Mathematical Universe
February 21, 2025 · Original source
Bulldog mentions consciousness, psychophysical harmony, and moral knowledge as proofs he especially likes which MUH doesn’t even begin to respond to. I agree consciousness is the primary challenge to any materialist conception of the universe and that I don’t understand it. I find the moral knowledge argument ridiculous, because it posits that morality must have some objective existence beyond the evolutionary history of why humans believe in it, then acts flabbergasted that the version that evolved in humans so closely matches the objectively-existing one. I admit that in rejecting this, I owe an explanation of how morality can be interesting/compelling/real-enough-to-keep-practicing without being objective; I might write this eventually but it will basically be a riff on the one in the Less Wrong sequences.
Psychophysical harmony is in the in-between zone where it’s interesting. The paper Bulldog links uses pain as its primary example - isn’t it convenient that pain both is bad (ie signals bodily damage, and evolutionarily represents things we’re supposed to try to avoid) and also feels bad? While agreeing that qualia are mysterious, I think it’s helpful to try to imagine the incoherence of any other option. Imagine that pain was negatively reinforcing, but felt good. Someone asks “Why did you move your hand away from that fire?” and you have to say something like “I don’t know! Having my hand in that fire felt great, it was the best time of my life, but for some reason I can’t bring myself to do this incredibly fun thing anymore.” And it wouldn’t just be one hand in one fire one time - every single thing you did, forever, would be the exact opposite of what you wanted to do.
Finally, I admit an aesthetic revulsion to the particular way Bentham is using “God” - which is something like “let’s imagine a guy with magic that can do anything, and who really hates loose ends in philosophy, so if we encounter a loose end, we can just assume He solved it, so now there are no loose ends, yay!” It’s bad enough when every open problem goes from an opportunity to match wits against the complexity of the universe, to just another proof of this guy’s existence and greatness. But it’s even worse when you start hallucinating loose ends that don’t really exist so that you can bring Him in to solve even more things (eg psychophysical harmony, moral knowledge). If there is a God, I would like to think He has handled things more elegantly than this, so that we only need to bring Him in to solve one or two humongous problems, rather than whining for His help every time there’s a new paradox on a shelf too high to reach unassisted.
psychoses1 mentions across 1 issues

psychoses is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between July 31, 2025 and July 31, 2025. The archive places it in contexts such as "preventing various cancers and psychoses". It most often appears alongside 23andMe, 23andme, Alex Young.

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psychoses
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July 31, 2025
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July 31, 2025
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Suddenly, Trait-Based Embryo Selection
July 31, 2025 · Original source
Aside from two bright orange squares (gallstones vs. hypertension and hypothyroidism - I don’t know what’s up with this and it doesn’t seem to be a widely-appreciated result) we see that most correlations are zero or positive - that is, selecting against one disease selects against another or at worst does nothing. In this ocean of blue, worrying about those few orange squares feels a bit motivated. Hans Jonas-ism says that no medical intervention may ever cause any harm, no matter how much benefit it produces. By this standard, perhaps slightly raising the risk of gallstones in the process of preventing various cancers and psychoses and other forms of human misery is unacceptable. To anyone with the more normal perspective where something with large benefits and tiny downsides is still pretty good, I don’t think the antagonistic pleiotropy argument carries much weight. Ethical Objection: Cost No way around this one: if these products work, they mean that rich people can have healthier/smarter/taller/prettier kids than poor people. One might object that at least they’re in good company: other products which help rich kids get healthier/smarter/taller/prettier than poor kids include private tutors, gyms, hair salons, health insurance, clothing, books, and food. Is this really the time to declare ourselves against this kind of thing? But maybe we should fight against expanding this already-bloated category. Or maybe there’s something more final about a genetic advantage. Maybe a stronger argument is that rich people get first crack at every new technology, but poor people usually follow close behind. The first cellphone, in 1982, cost $12,000 in today’s dollars. Now you can get something a thousand times better for $50, and Kenyan pastoralists use cell phones to call up the local shaman. The trajectory of genetics has been even more striking: sequencing a single genome cost about $100 million in 2000 and is somewhere around $100 today. Polygenic embryo selection has the potential to follow a similar path. There are two associated costs - sequencing the embryos, and running the analysis. Sequencing costs are decreasing and may eventually be comparable to the sorts of genetic screening (for e.g. Down Syndrome) that most families get anyway. Analysis costs are mostly the one-time expense of inventing the predictor; we might expect these to follow the same pattern as generic medications, where cutting-edge technology is jealously guarded and expensive, but last decade’s technology has made its way off patent and is cheap-to-free. A few groups have already created free open-source predictors; so far these are much worse than the private companies’ versions, but one of last year’s ACX Grantees is working on a better one. Also, it would be crazy for any forward-thinking government not to cover this; it could save hundreds of thousands of dollars in future health care expenses. In countries with public health care, this comes directly out of the government treasury; even in the US, it’s covered by Medicare after age 65. The government should be begging people to select embryos. The most persistent cost barrier is likely to be in vitro fertilization itself, a necessary precursor. In the US, 2-3% of babies are born through IVF. For those kids, this is a no-brainer - even if the cost never comes down, the cheaper products are only a fraction of total IVF expense. What about the other 98%? If those parents feel like they have to get embryo selection (and therefore IVF) to keep up, this could be a significant burden. IVF isn’t fun - it requires pumping a woman full of mind-altering hormones for weeks, extracting eggs in a minor surgery, and then implanting embryos in another minor surgery, all with a decent chance that some step will fail and you’ll have to do it all again. It also costs $15,000 in the US (less in poorer countries), and unlike the genetics, the cost has barely gone down in the past twenty-five years. Some countries, including Israel, offer free IVF for anybody who wants it. And universal basic IVF is surprisingly popular even in the usually government-phobic United States - Donald Trump made it part of his campaign platform. So there’s a plausible path to embryo selection for everyone who wants it. But it’s still going to take a while, it will hit different people at different times, and so far11 there’s no way around the month or two of various miserable medical procedures for women. Ethical Objection: Personhood Is it really correct to say that you have reduced someone’s risk of breast cancer by 46%, if what you’ve really done is closer to replacing them with a different person who is 46% less likely to have breast cancer? I cover this one in more depth here. Ethical Objection: Race This one is awkward: right now the technology works best for white people. Most genetic data available for research/commercial use comes from the UK, US, and Europe - areas which are mostly white. Asian biobanks, and those serving US minority communities, have been more reluctant to share data. So we know a lot about the genetics of white people, and only a limited amount about the genetics of anyone else. Companies are suitably embarrassed about this, and researchers in the field are working hard to wring every ounce of information out of the minority data they have. But for now, white people are the clear winner. Here’s data from Herasight: A European family with five embryos and no family history can cut their diabetes risk by 47%, and an African family 29%, with everyone else in between. As usual, all companies say that they adjust their scores based on the couple’s genetic ancestry. As usual, Herasight challenges them to publicly release data on exactly how they performed the adjustments and how well they work. All companies say they are working as hard as they can to improve cross-ancestry portability, but that progress will remain limited until governments collect/release better genetic data on non-white populations. Ethical Objection: Selection At some point, you’ve got to choose. Genomic Prediction and Herasight offer scores that aggregate overall health risks. Some people will follow them slavishly. Other people will try to second-guess them - would you prefer your child have lower cancer risk, or less chance of heart attacks? And this is the best case scenario! Herasight offers predictors for IQ, height and BMI; Nucleus offers those plus eye color and hair color12. A parent might encounter a situation where the embryo with their favorite eye color also has the highest cancer and schizophrenia risk, and choose to doom their child to cancer and schizophrenia because they really want pretty eyes. On average, even if everyone in the world selected for eye color, it wouldn’t raise cancer and schizophrenia risk. No not-deliberately-perverse polygenic selection choice can make your child worse off in expectation. Still, suppose you got cancer, and your mom admitted that she selected you for pretty eyes and didn’t even check the cancer column of the embryo selection report. How would you feel? And would you feel better or worse than someone whose parents didn’t do embryo selection at all, and spent the money on a Caribbean vacation? What if they selected your brother for everything great, then had you naturally? What if they selected you for IQ, but actually you are very stupid, and you were one of the 20% of cases where a predictor that’s right 80% of the time gets it wrong? Mark my words, one day there will be entire subfields of therapy dedicated to these issues. Going Nuclear Even as outsiders criticize the whole field, Herasight has launched a full-scale attack on competitor Nucleus. Herasight’s white paper compares its own predictors (favorably) to those of Orchid and Genomic Prediction… …but refuses to acknowledge Nucleus at all. In a supplementary note, the authors explain why: they accuse Nucleus of being so bad that it would “not yield a reliable or meaningful addition to our analysis”. They say Nucleus has inflated the accuracy of their scores. This is most dramatic for a few conditions like ADHD, where the leading published polygenic score is based on 2,300,000 variants but explains only ~1% of variance in the condition. Nucleus’ score is based on 12 variants13 and (implicitly) claims to explain 3-6%. This doesn’t make sense. Some of Nucleus’ other scores do use millions of variants. But many of these are 5-10 year old scores downloaded from open-source catalogs, whose accuracy statistics are easily available and far less than Nucleus claims. Here is what Herasight finds when they double-check Nucleus’ numbers: On their Substack, Herasight also criticizes Nucleus’ monogenic screening product. They point out cases where it fails to properly screen for the conditions it claims. For example, the Nucleus website advertises screening for spinal muscular atrophy: But on their gene list… …they don’t screen for SMN, which causes 95% of spinal muscular atrophy cases. They only screen for UBA1, which causes a distinct and much rarer condition called x-linked infantile spinal muscular atrophy. Professional organizations publish guidelines for what genes need to be screened in a screening product, and Nucleus does not appear to be following them. In further discussion, Herasight continued with exhaustive criticism of essentially everything Nucleus had ever done down to the smallest detail. Nucleus reports list the same baseline disease risk regardless of patient ancestry, but different ancestry groups should have different risks14. Nucleus’ physician reports sometimes list lower-than-average risk for patients with positive polygenic scores15. Nucleus’ age-based risk tables don’t distinguish between age and cohort effects (is this bad? see footnote16). My favorite critique is that Nucleus wrote a blog post criticizing competing company Orchid… …which included a section on how Orchid is a polygenic selection company, and polygenic selection companies are inherently “sketchy” and “honestly should be illegal”. But Nucleus is also a polygenic selection company! This is like Marlboro attacking Camel on the grounds that cigarettes are addictive and should be banned! Obviously something went wrong here - my guess is AI - and it’s a really bad look, especially when these scientific issues are so hard to litigate, and so many of us will have to go off gestalt impressions of corporate culture. Nucleus states that they validate their models internally and intend to make their results public soon. A Foothill Of The Future It’s hard not to love this technology. Lots of people (and the aforementioned professional organizations) manage anyway, but it’s hard. If this were a single-use medical treatment, delivered by a doctor after someone got the relevant condition, it would be one of the biggest advances of the decade - imagine a drug that cures 10 - 40%17 of breast cancers with no side effects! But in fact, it works for breast cancer, and schizophrenia, and heart attacks, and approximately everything else. The only things comparable are antibiotics and GLP-1RAs. And then there’s the IQ effects. Even after studying the literature, people have wildly different opinions about the importance of IQ. One of the most important debates is to what degree IQ differences are a cause of poverty, a consequence of poverty, or both. I lean towards both - a country with limited access to schools and medical care will have low average IQ, but as a consequence it probably won’t become the next big semiconductor hub. This technology could close half the IQ gap between poor and middle-income countries, or between middle-income and rich. Or it could give rich countries average IQs that have never been seen before, and let us see what kind of O-ring technologies (and new forms of social cooperation) lie just beyond the frontier. (this is the nice quantifiable argument in favor of IQ enhancement, but I find myself more convinced by fuzzier things - how much is it worth to be able to enjoy great art and literature? To fully comprehend what we know of nature, and be able to fully appreciate the mystery of the rest? To have a sense of why society works the way it does, instead of feeling like you’re being blown back and forth by institutions you don’t really understand? Amateur psychoanalysts like to say that the only people who care about IQ are those looking for an excuse to boast about how high their own is, but my experience is the opposite: I care about IQ because I bang up against the limits of my own a thousand times a day, and I hate it. I fantasize about ways to make my children smarter than I am for the same reason a dog confined in a tiny crate might fantasize about getting her puppies adopted out to a nice house with a big grassy yard.) My biggest qualm is that it might not matter. This is such a tiny foothill, flanking such a vast and foreboding range of mountains, that it might be a mistake to care about it at all. Selecting the best of five or ten embryos is not a very effective way to get the genes you want. There are things in the pipeline that will make this look like Hippocrates draining black bile. By the time the first polygenically selected children are adults, they’ll be old news. And then there’s AI. The average age at diagnosis for Type II diabetes is 45 years. Will there still be people growing gradually older and getting Type II diabetes and taking insulin injections in 2070? If not, what are we even doing here? Many people in the transhumanist community are still bullish on this technology. They think - well, there’s still an outside chance that something comes up and AGI takes another few decades. If we can enhance humans to be smarter, healthier, and more determined by the time it arrives, maybe we’ll have a better chance. Or maybe, if there’s a positive optimistic vision of a human-based high-tech future, people will be more willing to delay AI in the first place. I like this argument, but I also think it’s worth stepping back. What’s the point of anything? Why have kids at all in a world that’s changing this fast? Why save for the future? At some point your answer has to be romantic and aesthetic - it’s never been clear whether anything you do matters in any ultimate sense, but you’ve got to act as if it does and hope for the best. From that perspective, this is the most romantic technology of all. You’re not just giving a better life to your kids. Genes travel from generation to generation; you’re giving a better life your grandkids, your great-grandkids and so on to the point 1.77*log₂(population) generations from now when you are the ancestor of everybody and nobody. Somebody in Macaronesia in 3525 AD will avoid getting breast cancer because of you (if there is still cancer; if there are still breasts). Some combination of reasonable cost-benefit analysis and romantic/aesthetic commitments makes me want to have children despite the uncertainty, and the same combination made me sign up to use this technology despite the same. More later on how that’s going. 1I’m slightly mixing up two different things here - Down Syndrome can be detected with an aneuploidy test, but cystic fibrosis takes a more involved PGT-M test. 2There are two separate questions here. First, how much would diabetes risk decline if you selected the embryo with the lowest risk for diabetes - something you have no reason to do, since you have no reason to privilege diabetes risk over risk of any other disease? Second, how much would diabetes risk go down if you selected the embryo with the lowest health risk overall? Genomic Prediction’s their risk calculator calculator shows, seemingly paradoxically, that you get -38% relative risk by selecting against diabetes alone, but -41% relative risk by selecting against everything at once. Over email, they stand by this surprising result, saying that “for a couple of diseases (type II diabetes and CAD), the EHS actually accomplishes a larger risk reduction than the individual predictors. The explanation is that the EHS takes into account multiple PRS of diseases with high comorbidity”. See eg Figure 3 here: …and the section of the post called “Antagonistic Pleiotropy” for more. However, this paradoxical benefit is only true for a few conditions like diabetes - for everything else, selecting on health index does better than you would naively think, but still does not decrease the risk of a given condition as much as selecting against that condition directly. 3That is, new mutations in that particular baby, as opposed to older mutations already present in the parents. 4Conflicts of interest: I have used Orchid’s and Herasight’s products on my own embryos (not the ones used to conceive my existing kids, but for a potential third child), employees of Genomic Prediction and Herasight have been extremely helpful in contributing expertise to ACX posts on genetics, and I might invest in this field at some point (though haven’t done so yet). This post started as Herasight asking me to write about their white paper, then spiraled out of control. There were some unexpected time pressures and the result is that I didn’t get a chance to run everything in Herasight’s white paper by their competitors as thoroughly as I would like. Although I talked to representatives of all four companies profiled here, I feel like this probably reflects Herasight’s perspective better than other companies’, and that this is a major flaw. If other companies have responses, I’ll publish them. Thanks to all companies involved for their assistance on this article. Finally, I am favorably disposed toward Herasight because of how I learned about them: a professor named Jonathan Anomaly got cancelled from Penn for being too gung-ho about genetic enhancement, and used his newfound freedom to join a very-early-stage Herasight, raise their ambitions, and sell everyone (including me) on the idea. I grew up on a diet of books and movies about mad scientists, and I’m a sucker for a story about a guy named Doctor Anomaly pursuing revenge against the small-minded fools who destroyed his career by creating a race of superbabies. 5The version of the tool I looked at said 5.9 points for five embryos, up to 9 points for twenty embryos. The version of the tool on their current said says 5.3 - 9, so they might have recalculated after I finalized this article. 6Used in quotation marks because these scores were fine for the predictive tasks they were applied for - they just weren’t finding genes that directly caused the outcome of interest. 7Conflict of interest notice: this table was originally unadjusted. A representative of Herasight claimed that this was unfair, because each company used slightly different reporting conventions, and offered to correct for this in a neutral way. I retraced their reasoning, confirmed that the correction did not especially benefit Herasight at the expense of other companies, and accepted the correction. The original unadjusted table is below: Herasight was insufficiently comfortable with Nucleus’ methodology to even be willing to posit a corrected value, so I left their self-reported value in gray. 8Zagorsky (2007) says an extra IQ point means $234-$616/year in higher salary. The midpoint of $425 equals $670 in today’s dollars; assuming a forty-year career, Nucleus’ +1 point estimate is worth $26,800 (vs. $9,249 Nucleus cost) and Herasight’s +6 point estimate is worth $160,800 (vs. $53,250 Herasight cost). 9As part of researching this article, I asked all four major companies about their within-family validation strategies. Here are some details: Genomic Prediction discusses their strategy in this paper. The results are complicated to interpret - the within-family numbers often have such wide error bars that they overlap with both the across-family numbers and with zero - but looking qualitatively it seems like most scores on average lose about 25% of their risk reduction ability (though averages might not be the right way to do this, and some might be much more affected than others). Their website reports unadjusted, not within-family validated numbers; GP says they say this clearly on their site (which is true), Herasight counters that they still present their numbers as applicable to embryo selection (which is also true). To get the most applicable-to-embryo-selection numbers, you might want to adjust GP’s stated numbers down somewhat; it’s hard to say exactly how much, but maybe 20 - 25%?
Inline links: Hans Jonas-ism, somewhere around $100 today., Donald Trump made it part of his campaign platform, 11, here, https://substackcdn.com/image/fetch/$s_!1Alk!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F1af69f39-f353-4aa6-acb9-d8c3b05c7bac_728x895.jpeg, 12, Herasight’s white paper, https://substackcdn.com/image/fetch/$s_!S7lY!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F738260ba-8fe2-4647-8ca2-eeb4d13e0fce_605x341.png, 13, https://substackcdn.com/image/fetch/$s_!u7YE!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F451c286b-c677-47af-8c07-f0d993a14384_612x345.png, their Substack, the Nucleus website, https://substackcdn.com/image/fetch/$s_!XmL4!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Ff77915b4-3b36-4908-8f9f-032b7cf865ff_562x432.png, https://substackcdn.com/image/fetch/$s_!bxjb!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F2df9ffe5-17a3-4448-9a20-e9b27ac9a519_1250x795.png, publish guidelines, 14, 15, 16, a blog post criticizing competing company Orchid, https://substackcdn.com/image/fetch/$s_!MZCB!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F2cf9cbf4-825b-4373-9052-80e43c36febf_718x1035.png, 17, GLP-1RAs, O-ring technologies, things in the pipeline, everybody, nobody, 1, 2, their risk calculator, everything, here, https://substackcdn.com/image/fetch/$s_!jtkY!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fd645c392-fed1-4f02-9a2e-878b8c7ef7f2_909x878.png, 3, 4, 5, 6, 7, https://substackcdn.com/image/fetch/$s_!Vimq!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fca0f1f15-268d-465a-a70f-b7f1173c6111_566x166.png, https://substackcdn.com/image/fetch/$s_!3B0A!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Faccc7a65-b142-4bf6-927d-53eb607d71ef_552x155.png, 8, 9
psychosis1 mentions across 1 issues

psychosis is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between March 07, 2024 and March 07, 2024. The archive places it in contexts such as "research psychosis in velocardiofacial syndrome". It most often appears alongside ACX, ACX Grants, ACX Grants.

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psychosis
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ACX Grants Followup Impact Market
March 07, 2024 · Original source
You’ve probably encountered vaticidalprophet in the ACX comments section or the ACX Discord, and heard their spiel about why researching schizotypy is interesting. They want $2K - $50K to research psychosis in velocardiofacial syndrome (DiGeorge/22q11.2 deletion syndrome), which might shed more light on the relationship between schizophrenia, schizotypy, autism, and psychosis. We decided not to fund this because velocardiofacial syndrome is rare, understanding it better wouldn’t directly help many people, and we weren’t convinced this would have knock-on effects for more common psychiatric diseases - but I would love to be proven wrong.
Inline links: research psychosis in velocardiofacial syndrome (DiGeorge/22q11.2 deletion syndrome)
psychotic disorders1 mentions across 1 issues

psychotic disorders is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between June 23, 2022 and June 23, 2022. The archive places it in contexts such as "people with psychotic disorders are completely crazy". It most often appears alongside 1978, 2016 essay, A Resounding Success Or Disastrous Failure: Re-examining The Interpretation Of Evidence On The Portuguese Decriminalisation Of Illicit Drugs.

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psychotic disorders
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Book Review: San Fransicko
June 23, 2022 · Original source
The San Francisco districts with the highest (left) and lowest (right) homelessness rates. I correlated homelessness rate and population-adjusted density in the same cities I looked at above, but it didn’t add much predictive value to housing prices. Maybe this is restriction of range (all big cities are dense enough to have homelessness, compared to suburbs), or maybe the key feature is relative rather than absolute density (ie the homeless will go to the densest place nearby). Conclusion: No social phenomenon is ever caused by just one thing, but San Francisco’s homelessness rate is around where a housing-cost-based model would predict. San Fransicko briefly touches on this, but overall tries to de-emphasize it in favor of talking about drugs and mental illness. Critiques of patterns of emphasis are necessarily subjective, but the book’s pattern feels misleading to me. Claim 2: Standard Accounts Underemphasize The Role Of Drugs And Mental Illness In Homelessness Having argued homelessness isn’t just about poverty, the book goes on to say we’re neglecting the central role of mental illness and substance abuse: Over the last decades there were many visible signs that homelessness was about much more than poverty and housing. Between 2010 and 2020, the number of calls made to San Francisco’s 311 line complaining of used hypodermic needles on sidewalks, in parks, and elsewhere rose from 224 to 6,275. In 2018, footage of dozens of people slumped over in an entrance to a Bay Area Rapid Transit (BART) station, many with needles in their arm, went viral. “We call it the heroin freeze,” said one local. “They can stay that way for hours.” Said another, “It’s like the land of the living dead.” For decades researchers have documented much higher levels of mental illness and substance abuse among the homeless than in the rest of the population. It’s true that just 8 and 18 percent of homeless people point to mental illness and substance abuse, respectively, as the primary cause of their homelessness, but researchers have long understood that such self-reports are unreliable due to the socially undesirable nature of substance abuse, and the lack of insight that often accompanies mental illness. Using other methods, San Francisco’s Health Department in 2019 estimated that 4,000 of the city’s 8,035 homeless, sheltered and unsheltered, are both mentally ill and suffering from substance abuse. Of those 4,000, about 1,600 frequently used emergency psychiatric services. Shellenberger’s source for 4000 homeless people having these issues is this SF Chronicle article, which seems to based off of this report. The report does estimate 4000 homeless people with mental illness and substance abuse, but it uses a yearly rather than point estimate of homelessness, and finds 18,000 rather than 8,000 people. That means it only finds a 22% rate of these problems, not a 50% rate. Thanks to commenter Sean for hunting down this report and helping explain this. I looked for other statistics to provide context on this number. This 2013 San Francisco Homeless Count found that 29% admitted chronic depression, 15% PTSD, and 22% some other mental illness. About 30% admitted to a substance use disorder, although as far as I can tell this is just the number who admitted it was a disorder, so maybe more used drugs. This article by the Los Angeles Times describes an LA study finding that 25% of homeless people had mental health issues and 14% had drug issues. The Times re-analyzes it in a way that ups the numbers to 34% and 46%, respectively. But they don’t say exactly what choices they made differently, and the few they do give don’t really inspire confidence. Although in some cases they count questions clearly about mental illness which the official definition inexplicably refused to count, in others they decide to count anyone who has ever had mental illness, reversing a government decision to require the mental illness to be long-term (does this mean that if I lost my house tomorrow, the LA Times use me as an example of a “mentally ill homeless person” because I saw a psychiatrist for OCD when I was a kid?) Studies like these don’t show causation. Sure, mental illness can make people homeless. But homelessness can also cause mental illness. One SF study found psych diagnoses among the homeless to be evenly divided among depression, PTSD, and everything else. Homelessness is a depressing and traumatic environment. Just because someone who’s been on the streets for a year has depression or trauma, doesn’t mean that we should attribute their homelessness to mental illness. This study by the California Policy Lab does better. It asks what factors played a role in homeless people losing their homes, and finds that 50% of unsheltered and 17% of sheltered homeless point to mental illness (given SF’s balance, that suggests 37% of SF homeless would point to that problem). But I can’t help but notice that when you add up the percent of people who lost their homes due to physical illness, psych illness, and drug use, it totals 147%. Based on numbers from other studies, it looks like if you added in job loss, eviction, etc, the numbers would total well above 400%. This makes me think people are saying “yes” if the factor played even a minor role in their eventual homelessness, and this shouldn’t be treated as 37% of homeless having mental health issues being their main problem. The same study finds that about 66% of the homeless “have” some mental health problem, but this time they don’t tell us what question they asked or what criteria they use. What about psychosis in particular? This meta-analysis claims that in developed countries (a category to which San Francisco still nominally belongs) about 19% of homeless people qualify for diagnosis with a psychotic disorder, including 9% with schizophrenia in particular. Not all people with psychotic disorders are completely crazy all the time, and some very much are not, but this is at least a specific condition with real criteria. Conclusion: Overall, I’m disappointed in most of the published research on this question, which seems more interested in producing glossy brochures about funding disparities than in informing anybody what any of their numbers mean. But putting it all together and squinting really hard, I think we can tell a story where 10-20% of the homeless are seriously psychotic, and another 20-30% have contributing mental health conditions including depression, PTSD, and others. Somewhere between 25% and 50% of the homeless have substance abuse problems, and this probably mostly overlaps with the 25% - 50% who have psych diagnoses. I think San Fransicko gets this mostly right. Claim 3: “Housing First” Isn’t As Great As People Think, And Might Be Harmful The National Myth About Homelessness is that The Bad People are refusing to give people houses until they’ve “proven” they “deserve” them, thus perpetuating homelessness when they inevitably fail to qualify. The Good People have united under an exciting new banner called “Housing First” to push the revolutionary idea that people should get houses regardless of whether they conform to normal standards of respectability or not. Wherever this is adopted, homelessness rates fall, and the formerly homeless becoming healthier, safer, and more likely to re-integrate into society. Best of all, the program pays for itself in decreased health care and policing costs. The only impediment to solving homelessness everywhere is the Bad People who still insist on not housing the homeless until they’ve “earned” it. In real life, everyone important has been united under Housing First since the Bush administration made it national policy fifteen years ago, and most of the cities with spiraling homelessness crises have been pursuing Housing First policies for decades (eg San Francisco has been trying Housing First since the 1990s). The Obama and Trump administrations both set funding policies that penalized any non-Housing-First welfare programs. Still, everyone is sure that the reason there are still homeless people must be that some Housing First opponent still exists somewhere, ruining everything with their purity-testing ways. But actually these people have already been relegated to the conservative think tanks where moribund ideas go to die. I have looked through a lot of studies and articles to try to see how well Housing First works. I am most sympathetic to the conclusions of Tsai (2020), who basically says that: Homeless people who are given houses are more housed than homeless people who are not given houses. Way, way more housed. You would not believe how strong of an effect giving someone housing has on them being housed. The same is true for other outcome measures like “time spent experiencing homelessness”, “number of days spent in a temporary homeless shelter”, etc. You might think this is obvious, but this is used as the primary outcome in a lot of studies, and “success” on this metric is behind a lot of claims that “studies show Housing First works great!”
Inline links: this SF Chronicle article, this report, 2013 San Francisco Homeless Count, This article, This study, This meta-analysis, some very much are not, made it national policy, since the 1990s, funding policies, Tsai (2020)
PT Swift Boat1 mentions across 1 issues

PT Swift Boat is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between December 09, 2022 and December 09, 2022. The archive places it in contexts such as "John Kerry had "get medals commanding a PT Swift Boat" on his career checklist". It most often appears alongside 417th Marquess of Cornwallshireshire, ACX, ACX.

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PT Swift Boat
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December 09, 2022
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December 09, 2022
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Highlights From The Comments On Bobos In Paradise
December 09, 2022 · Original source
...his sons felt they needed to distinguish themselves in battle if they wanted a chance at political office. As late as the 1960's, John Kerry had "get medals commanding a PT Swift Boat" on his career checklist. - [Most importantly], public displays of family values - If you are smart, wealthy and conscientious enough, you can play the field, settle dow...
...ng his family into the WASP elite, both his sons felt they needed to distinguish themselves in battle if they wanted a chance at political office. As late as the 1960's, John Kerry had "get medals commanding a PT Swift Boat" on his career checklist. - [Most importantly], public displays of family values - If you are smart, wealthy and conscientious enough, you can play the field, settle down late, cheat on your wife...
PTB perplexity1 mentions across 1 issues

PTB perplexity is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between April 04, 2022 and April 04, 2022. The archive places it in contexts such as "GPT-3 further showed ... capabilities ... which are not measured in PTB perplexity". It most often appears alongside 2013, Agricultural Revolution, AI.

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PTB perplexity
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April 04, 2022
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April 04, 2022
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Yudkowsky Contra Christiano On AI Takeoff Speeds
April 04, 2022 · Original source
In the comments, Matthew Barnett points out that on something called Penn Treebank perplexity, a benchmark for measuring how good language models are, the GPTs mostly just continued the pre-existing trend:
In other words, suppose AIs start at Penn Treebank perplexity 100 and go down by one every year. After 20 years, they have PTP 80 and are useless. After 21 years, they have PTP 79 and are suddenly strong enough to take over the world. Was their capability gain gradual or sudden? It was gradual in PTP, but sudden in real-life abilities we care about.
That is: when will an AI achieve Penn Treebank perplexity of 0.62? Based on the green line on the graph above, probably sometime around 2027. When will it be able to invent superweapons? Nobody has any idea. So who cares?
PUAs1 mentions across 1 issues

PUAs is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between May 10, 2021 and May 10, 2021. The archive places it in contexts such as "Mansplaining? #NotAllMen? MRAs and PUAs?". It most often appears alongside "How do you do, fellow kids?", #NotAllMen, #TheResistance.

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PUAs
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1
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May 10, 2021
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May 10, 2021
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The Rise And Fall Of Online Culture Wars
May 10, 2021 · Original source
When was the last time you heard people argue about "creeps", "nice guys", or "friendzoning"? Mansplaining? #NotAllMen? MRAs and PUAs? If you're in your early 20s, you might not even know what half these terms mean; if you're older than that, you’ll remember them with a sort of cold dread. But they're gone now - you'd have more luck looking for recent discourse about Osama bin Laden. Nor has some some other gender discourse arisen to replace them. Everyone just stopped caring and moved on to race.
Earlier eras of social justice had their enemies. Around 2010, some people who didn't like feminism banded together under the umbrella of "men's rights advocates" (MRAs). Pickup artists (PUAs) were originally a totally different group - guys who talked a lot about the best ways to pick up girls - but many of them merged into the generic anti-feminist current for complicated reasons. "Red Pillers" were a third group, vaguely related to the previous two, whose main contribution to the discourse was giving us the terms "alpha male" and "beta male" (I guess these became "Chad" and "virgin" at some point). Sometimes all of these groups together called themselves "the manosphere".
public choice model1 mentions across 1 issues

public choice model is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between June 24, 2022 and June 24, 2022. The archive places it in contexts such as "IR specialists can imbibe the public choice model". It most often appears alongside 501(c)(3), 80,000 Hours, 9/11.

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public choice model
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June 24, 2022
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Your Book Review: Public Choice Theory And The Illusion Of Grand Strategy
June 24, 2022 · Original source
[In Public Choice Theory And The Illusion Of Grand Strategy], Richard Hanania details how a public choice model (imported from public choice theory in economics) can explain the United State’s incoherent foreign policy much better than the unitary actor model (imported from rational choice theory in economics) that underlies the illusion of American grand strategy in international relations (IR), in particular the dominant school of realism. As the subtitle How Generals, Weapons Manufacturers, and Foreign Governments Shape American Foreign Policy suggests, American foreign policy is driven by special interest groups, which results in millions of deaths for no good reason.
Inline links: Public Choice Theory And The Illusion Of Grand Strategy, public choice theory, rational choice theory, grand strategy, realism
In the public choice model, small special-interest groups that reap a large proportion of the benefits from a policy (concentrated interests) are much more incentivised to lobby for a policy than the general public who pay for a negligible portion of the cost of the policy (diffused interests) are incentivised to lobby against. The former can coordinate much easier than the latter that has to overcome rational ignorance (the cost of educating oneself about foreign policy outweighs any benefit an one can expect to gain as individual citizens cannot affect foreign policy) and the society-wide collective action problem (irrational for every citizen to cooperate in the prisoner’s dilemma especially if individual gain is negligible) resulting in inefficient (not-public-good-maximising) policymaking i.e. government failure.
Inline links: rational ignorance, collective action problem, government failure
Second, Posner and Vermeule argued that the executive branch of the US government can be considered a united force capable of outmanoeuvring a Congress divided by power, which leads to a federal government that is more responsive to public opinion via elections and politics (rather than laws) to better solve problems. Afterall, politicians are political — they are selected based on their ability to convince others of their sincerity, likability, and competence, not necessarily their ability to solve problems, and especially not to solve problems that will arise after they have left office. 2. Hello Public Choice Model Public choice theory was developed to understand domestic politics, but Hanania argues that public choice is actually even more useful in understanding foreign policy.
public choice theory1 mentions across 1 issues

public choice theory is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between June 24, 2022 and June 24, 2022. The archive places it in contexts such as "public choice model (imported from public choice theory in economics)"; "one of the founding fathers of public choice theory". It most often appears alongside 501(c)(3), 80,000 Hours, 9/11.

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public choice theory
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Your Book Review: Public Choice Theory And The Illusion Of Grand Strategy
June 24, 2022 · Original source
[In Public Choice Theory And The Illusion Of Grand Strategy], Richard Hanania details how a public choice model (imported from public choice theory in economics) can explain the United State’s incoherent foreign policy much better than the unitary actor model (imported from rational choice theory in economics) that underlies the illusion of American grand strategy in international relations (IR), in particular the dominant school of realism. As the subtitle How Generals, Weapons Manufacturers, and Foreign Governments Shape American Foreign Policy suggests, American foreign policy is driven by special interest groups, which results in millions of deaths for no good reason.
Inline links: Public Choice Theory And The Illusion Of Grand Strategy, public choice theory, rational choice theory, grand strategy, realism
Public choice theory was developed to understand domestic politics, but Hanania argues that public choice is actually even more useful in understanding foreign policy.
The press should include Tetlock’s superforecasting/prediction markets when reporting the forecasts by the military and national security bureaucracy at public interviews, official reports, and congressional testimony 7. Conclusion And Further Readings Gordon Tullock, one of the founding fathers of public choice theory who coined “rent-seeking”, has always wished for a book like this, and now it exists. It is clear to me that Hanania’s public choice model should usurp the conventional unitary actor model, and any scholar who insists on American grand strategy is deluding themselves. The book hasn’t been reviewed by mainstream outlets (which probably only reviews “pop” nonfiction), but have been unanimously praised by scholars in adjacent fields: Steven Pinker praised it as “cynical but probably accurate”; Robin Hanson was “quite impressed”, Byran Caplan, whose work The Myth of the Rational Voter was cited extensively by Hanania, praised it as “eye-opening”; Tyler Cowen praised the book as impressive in spite of finding Hanania’s view to be more sceptical than his own — a sentiment I share after reading about the East Asian economic miracle (the greatest anti-poverty program in history) facilitated by American intervention in How Asia Works (another contrarian economics-related work I’ve reviewed). Russian Invasion of Ukraine At the time of writing, Russia is invading Ukraine, so it is interesting to see how well the public choice model’s predictions fit. Indeed, the unitary actor model can describe autocratic states to some degree — to understand Russia we only have to get into the head of Putin (the model still falls short in accounting for the oligarchs who run the mafia state). Ukraine is central to Putin’s ideology and subjectively important to Russian society, and the desire to obliterate and absorb the nation of Ukraine far predates the history of NATO (see also Adam Tooze’s excellent essay on understanding Russia as a strategic petrostate). As Hanania writes on his Substack (worthy of your subscription, by the way)4: We know what the Russians want. They have made clear, openly and consistently, that they do not want NATO to keep expanding. When it became apparent in December that an invasion was on the table, the US started a diplomatic process that has involved trying to work out concessions on other things, while refusing to take NATO membership for Ukraine off the table. Putin has become Satan in liberal imagination, and when it comes to the culture war, the emotional response is overwhelming. Hanania writes: Brexit, Trump, and the rise of Orban and other right-wing populists in Europe have helped solidify a narrative in which Russian hackers and influence operations are behind everything liberal elites find distasteful, from opposition to Syrian refugees to bans on Critical Race Theory. Here’s a website laying out all the things Russia has been accused of “weaponizing” in the media, including dolphins, federalism, and the weather. The details of debates surrounding the wisdom of NATO expansion and whether Ukraine actually matters to the United States are lost in the larger story, as emotional denunciations of Putin as the source of all anti-democratic activity drives attitudes and policies. Inconvenient facts are ignored because it’s not really about “democracy,” “international law,” or any of the other words they use to obscure the fact that it’s culture wars all the way down. And the Western response is driven by extreme public outcry to an unprecedented extent: It’s all a competition to see who can signal “I hate Putin” the most, but Germany was still shutting down all its nuclear power plants to rely on Russian gas despite warnings from every other EU state (Russia accounts for 40% of Europe’s gas imports) — so much for grand strategy. That is not to excuse Putin’s invasion (he is, after all, the aggressor) and no, Ukraine is not “the West’s fault” as Mearsheimer has claimed in his viral lecture, but “NATO’s door remains open” for me and “we're going to start WW3 because you're in my sphere of influence” for thee is no grand strategy at all. Indeed, the irrational Western response is not predictable by the unitary actor model, but by the public choice model. Hanania writes: If you were going to cut Russia off from SWIFT, for example, why wouldn’t you announce it beforehand? The whole point of a punishment like that is supposed to be its deterrent effect, but if you don’t communicate that a specific action will happen, then it can’t influence behaviour. The answer here seems to be a lack of grand strategy, with leaders responding to events according to emotion and public relations more than anything. Cutting off SWIFT, or even threatening to do so, seems extreme before an invasion occurs, but not after it has begun. The West cannot rely on sanctions to make Russia abandon its core national security interests, which at the very least include a no-NATO commitment, the acceptance of the secession of Donetsk and Luhansk, and the recognition of the annexation of Crimea. Sanctions will also push Putin closer to Beijing, and the US will continue down the self-defeating path of alienating both of the other two superpowers — so much for American grand strategy. Hanania writes: Even if Putin has maximalist aims at this point, that doesn’t mean sanctions are worth doing. Their costs are high and they may have major consequences for the global economy. One has to consider the possibility that they make Russia more repressive at home and more brutal in its persecution of the war. Putin is getting sanctioned, but ordinary Russians are getting cancelled. The Metropolitan Opera of New York has announced it will no longer stage performers who have supported Russian President Vladimir Putin. Carnegie Hall has done the same, and the Royal Opera House in London is cancelling a planned Bolshoi Ballet residency (one of the oldest and most prestigious ballet companies in the world). Eurovision banned Russia. Tchaikovsky is cancelled. As Tyler Cowen writes, cancel culture against Russians is the new McCarthyism. The culture war has morphed into a hyperreal form on the Internet. Just as COVID is the first pandemic in the Age of Twitter, so the Ukraine invasion is, in some sense, the first war in the Age of Twitter. As it unfolds, we are seeing many disturbing parallels to the events of early 2020. People are rapidly normalising once-fringe ideas like a NATO-enforced no-fly zone (while completely oblivious to the fact that it means shooting down Russian planes and causing WW3), direct US conflict with Russia, regime change in Moscow, and even, incredibly, the use of nuclear weapons. The overnight flips on German defence spending and SWIFT are like the overturning of conventional public health policies on masking and lockdowns. We have entered the age of shitpost diplomacy, as coined by Tanner Green, in which the official Twitter account of the US Embassy in Kiev literally posts memes to spite Putin: A Russian sixth-grader could explain why celebrating the glories of Kievan Rus does not subvert Putin’s claims about the history of the Russian nation so much as reinforce them. Just like Hong Kong’s protests, Ukraine has won the meme war with utterly lopsided propaganda and unanimous international support on the Internet. As Yoshimi writes: Floating ghostlike above it is our war, the myth of the ‘Ghost of Kyiv’, ace MIG-29 pilot who has apparently shot down six Russian planes, or the legend of the Ukrainian soldiers defending an island outpost who replied “Russian warship go fuck yourselves” to a surrender offer and may or may not have died heroically, or two Russian II-76 transport aircraft that maybe were shot down near Kiev, or videos of air strikes or dead bodies which variously are Russian or Ukrainian until they turn out to be from Gaza six years ago, or the viral video of an old Ukrainian woman telling off a Russian soldier by offering him sunflower seeds so when he dies, sunflowers (Ukraine’s national flowers) will sprout from the soil. We’re raising funds for the Ukrainian army on crowdfunding apps and giving advice to the civilians being handed assault weapons about how to disable tanks, sharing weird homophobic pictures of Putin as a gay icon and spamming Russian government posts. Ukrainian president Volodymyr Zelensky has made the decision to stay and fight rather than flee like most would-be leaders who go all in for American foreign policy, and now is being deified by us as “badass”, “a true leader”, etc. etc., alongside his people, whose resistance to authoritarianism we are told is unparalleled in the modern world. After all, so it goes, who could be next? And like in Hong Kong, despite winning the culture war in hyperreality, the actual war in reality is won by the side with overwhelming military might, not morality. The real war is where Ukrainians are experiencing the genuine life-shattering effects of military conflict. It matters because this is the first time Western response is driven by Twitter outcry, and it will not be the last. A New EA Cause? Besides Hanania’s recommendations in the last section (which he admits are more or less impossible in an excellent interview with Caplan), a worthy EA priority might be to somehow turn the public tide on sanctions, which literally kill more people than Putin. Americans should be appalled by the atrocity committed in their names. The banality of the incompetence of foreign policy elites does not excuse their evil. With how entrenched the special interests are, I have no idea if it’s even worth trying, but at the very least the sheer amount of suffering and death from sanctions should be made common knowledge. Nuclear security is one of the top priorities in Effective Altruism, per 80,000 Hours, Future of Life Institute, and Our World In Data. Toby Orb, who wrote the definitive book on existential risk, The Precipice, estimates x-risk from nuclear war to be ~1 in 1000 in the next century. Luisa Rodriguez estimates a 1.1% chance of nuclear war each year and that the chances of a US-Russia nuclear war may be in the ballpark of 0.38% per year; summarised by Max Roser as: Nuclear risk is neglected by the public because of Pax Americana since the collapse of the USSR, and is not discussed as often in EA as it’s thought to be relatively well-funded and mainstream, but in fact major donors like the MacArthur Foundation have been withdrawing funding. As Joan Rohling details in an 80,000 Hours podcast there is much to be done, especially when Ukraine gave up their nuclear arsenal in 1994 in exchange for Russia’s promise to never threaten or use military force against them. A worthwhile adjacent cause area might be de-escalation of public outcry to reduce x-risk from nuclear war beyond just regular anti-proliferation efforts — even a Russian specialist from the RAND Corporation is surprised by how much public outrage is driving policy: Even just the pace of the sanctions: we went to 11 out of 10 in like two days — farther than many expected we’d ever get in short order. And I think the same is true about these military assistance initiatives. We’re just trying to do something because there’s a public demand for action. So that’s what worries me, that the sort of public outrage that’s being channeled in Western democracies through political systems could result in decisions that prove ultimately unwise. Despite how odd it is that some wars are “legal” while others aren’t, we should be glad UNSC exists as much as everyone laughs at how useless the rest of the UN is. All is fair in love and war, but international norms is all that stands between us and nuclear annihilation. It is hard to emphasise just how delusional it is for the public to fixate on no-fly zones — I, like Scott, am surprised we’re still capable of jingoism. 80,000 Hours has updated their top career recommendations to include China specialist to improve China-Western coordination on global catastrophic risk, which seems more important after reading how irrational and captured the American foreign policy apparatus is. As Hanania writes, “great power competition” is an anachronism. If Ukraine is the first war warped by hyperreality, it won’t be the last. Now that US foreign policy elites have driven Putin into the arms of China, let’s hope IR specialists can imbibe the public choice model instead of antagonising yet another nuclear rival. Public Choice Theory and the Illusion of Grand Strategy is an important work because it raises the sanity waterline, which at the least should make us stop killing millions for no reason, and at the most should make the human race more knowledgeable of how to prevent total extinction from nuclear armageddon. Pax Americana is dead, but a multipolar world will be more humane. Endnotes In the fiscal year 2018, the top five government contractors were all weapons manufacturers, with Lockheed Martin in first place at $40.6 billion. The Department of Defence spent $358 billion on contracting, ten times higher than second place Department of Energy. Collective action problems that stop a bunch of smaller companies from effectively influencing policy are no hindrance for companies like Lockheed Martin.
Inline links: Gordon Tullock, cynical but probably accurate, Robin Hanson, The Myth of the Rational Voter, eye-opening, impressive, reviewed, predates, essay, writes, website, public outcry, https://substackcdn.com/image/fetch/$s_!R3g3!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F693f0593-7460-4fb0-bc4a-e185cf6f0e06_964x506.png, not, viral lecture, NATO’s door remains open, we're going to start WW3 because you're in my sphere of influence, writes, writes, cancelled, banned, cancelled, writes,, German defence spending, shitpost diplomacy, posts, https://substackcdn.com/image/fetch/$s_!j4gR!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F3c5db00c-e420-4b54-b826-b85d9ddf186d_900x647.png, writes, interview, 80,000 Hours, Future of Life Institute, Our World In Data, The Precipice, ~1 in 1000, estimates, summarised, https://substackcdn.com/image/fetch/$s_!PRc2!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2Fe90b1bb5-d84b-45dc-b9fa-2edddbf6b9fa_1600x1006.png, Pax Americana, MacArthur Foundation, details, gave up, surprised, Scott, jingoism, China specialist, captured, writes, the sanity waterline, a multipolar world will be more humane
public interest movement1 mentions across 1 issues

public interest movement is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between June 23, 2023 and June 23, 2023. The archive places it in contexts such as "By creating what’s now called the public interest movement". It most often appears alongside 1965, 1968 Summer Olympics, 2000 election.

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1
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1
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June 23, 2023
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June 23, 2023
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Your Book Review: Public Citizens
June 23, 2023 · Original source
How’d he do it? By creating what’s now called the public interest movement: a new form of activism through which citizens force change—or, more often, block change—by suing the government. Though it was begun with the best of intentions and achieved some real good along the way, this political innovation led to the constipated governance we all complain about today.
And so on, and so on, and so on. Nader and his acolytes spawned generations of copycats and they sued and advocated and sued and advocated and in response, we blanketed government agencies under new layers of rules that constrained how they could operate. The public interest movement wasn’t the only force behind this push for procedure, of course. But it was a major one.
Individually, the changes the public interest movement pushed for—among them, comment periods for rulemaking, thorough environmental review, pre-enforcement review of agency rules, and ubiquitous court challenges—seemed like reasonable ideas. But collectively, they stymied the government's ability to do anything. Ironically, the very policies the progressives of the seventies helped put in place now stand in the way of the government action today’s progressive movement demands.
public speaking1 mentions across 1 issues

public speaking is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between June 27, 2025 and June 27, 2025. The archive places it in contexts such as "Academic competitions like chess, go, debate, public speaking". It most often appears alongside 10,000 hour rule, 2 Hour Learning, Inc, 2-hour Learning.

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public speaking
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1
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1
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June 27, 2025
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June 27, 2025
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Your Review: Alpha School
June 27, 2025 · Original source
Same state curriculum, same worksheets, same pace. The school philosophy was “no acceleration—just go deep.” We knew this was the philosophy going in. The pitch was that instead of accelerating through the state curriculum the teachers would take their time with the kids and allow them to fully explore and master the content of each grade. When we asked for examples of what that meant in practice we were told things like: “Instead of reading more advanced vocabulary, the students will learn to read out loud and use emotion and character impressions. They will learn how to vary the timing of their reading like where and when to pause to create emotion in the listener”. That sounded reasonable! It sounded like more learning, but just different learning than what the state had mandated. In practice that was not what happened. In practice “deep” just meant “un‑measured.” Smart kids + small classes ≠ accountability. The kids had time to do music, lego building, theatre and Friday ski trips because they were all really bright. They didn’t need 6+ hours a day to learn the limited math required by the state, and since the school did not feel the need to advance faster than the state, there was no pressure to push learning at all – on anything really. There was no overall school curriculum. Every teacher did their own thing. While one first grade class had weekly spelling bees, the teacher in the other classroom did not believe in learning spelling at all. But it didn’t matter. The metrics they measured the kids on in both classes advanced “enough” that no one was concerned. Most time wasn’t spent on math or language anyway. Beyond the brochure activities like skiing and theater and the four hours of foreign language per week they split between Spanish and Mandarin (which was really a great opportunity for the kids who already spoke Spanish and Mandarin to have their egos flattered. I did not see any learning in either language class. I don’t see how you can teach a language a couple of hours a week to a group of 18 kids with skill levels from zero to fluency and expect to have any impact), a lot of time was spent on DEI. DEI was pitched as helping kids handle the emotions that often come from being sensitive gifted children (they called it “Synapse”). In practice my oldest daughter got four years of learning about the basic ideas of Martin Luther King Junior and Rosa Parks, a rough understanding that some people are non-binary, and a great deal of anxiety every time I left the water running while I was brushing my teeth. The talent drain In Spring 2024 the “intermediate-school” head resigned, as did the 40+ year veteran science teacher we had been looking forward to our daughter having, the beloved tech teacher who had built a her own proprietary “learn to type” software, plus half the lower‑school faculty. Our oldest was going to be entering fourth grade; her incoming roster read like a rebuilding year for a professional sports team. It was possible we could get her into a middle school that would feed into a top tier high school, but those did not start until 5th grade. Our best option looked like “suck it up and accept whatever we had for at least a year”. One option was to do something radical. We considered taking a GAP year and traveling the world with an organization called “Boundless” but decided the timing wasn’t right. Earlier in the year we had started exploring moving to the charter city of Prospera. There is a Montessori school there that seemed like it might be alright. And we could surround the kids with an interesting group of people (and live on the beach!). But by the spring we had ruled it out. There did not seem to be many families as part of the community and we were not comfortable with the risk profile based on what was happening with the conflict between Honduras and their charter cities. Then I stumbled across Alpha: Two‑hour mornings, life‑skills afternoons, claims of 2x learning. Marketing copy is cheap; still, the promise was different enough to warrant due diligence. The initial plan was to fly some of the kids to Austin for an Alpha summer camp for a week in June – just to try it out. But once we started exploring more my wife asked me: “Could we actually move to Austin and try it for a year? Based on what is happening at the kids' school, this might be the year to try it.” So over eight weeks we flew to Austin five times – conversations with admissions and school heads, real estate searches, kids doing shadow‑days. Every parent we spoke to was very impressed with the school. Their kids really were advancing at 2x+ speed – and no one believed it was just a “selection effect”. And every guide I spoke to was extremely impressive themselves. They reminded me of the staff you run into when visiting Disney World. They all seemed “full faced” and fully-engaged. When I asked the head of admissions how they found such good staff he told me their compensation was fully transparent. “Associate Guides” were paid $60,000/year (vs the $40,000 average for Austin teachers), “Full Guides” made $100,000 and the five “Head Guides” in the school each made $150,000. They were able to both poach the best teachers from other schools, but also bring exceptional people into teaching that would not have considered it otherwise. It also let them have very high expectations for teachers once they were hired. We pulled the trigger in July. New house. Admissions letter signed. Moving truck (plus car-mover) scheduled for October. Worst case, it would be a one‑year sabbatical from stagnation. The hypothesis I carried south Elite private school attendance buys you smaller classes, brighter kids, and fancier field trips – not academic acceleration. If Alpha was real, we’d see that differential, measurable impact by Christmas – that was when we would need to decide if we would cut bait and re-apply to schools back home (and sign the kids up for more IQ-tests. The school would not accept old ones). That prior—show me velocity, not polish—is the lens through which the rest of this review should be read. Part Two: A History of Alpha Note: This is my best attempt at piecing together the history of the school based on conversations with co‑founder MacKenzie Price, high school head Chris Locke, Alpha staff, and Alpha parents; All dates are estimates and I am SURE I have gotten some details wrong. I will come back after the fact in the comments and make corrections as I hear from the people involved with corrections. 2013 – 2017 | Garage‑School to “Alpha” MacKenzie Price, then a mortgage broker in Austin, wasn’t impressed by the city’s gifted programs. She invited a small number of neighbourhood kids (including her two) into a makeshift microschool that ran two intense, teacher‑led academic “sprints” each morning, then “life‑skills” projects after lunch. Joe Liemandt — Founder of Trinity Technology, ESW Capital billionaire and family friend (MacKenzie’s husband worked for him) — kept his own children in conventional private school until he saw the qualitative improvement in the life skills of MacKenzie’s kids. He decided he wanted his kids to join MacKenzie’s but he wanted to take the project to the next level. Sometime around 2014-2017 he joined MacKenzie as a co-founder and started writing checks. Alpha recruited more students and guides and the operation jumped from location-to-location looking for a larger permanent home. 2017 – 2020 | K-8 Expansion and 2-hour focus Alpha grew to roughly 90 students from K‑8 and stabilized. Morning “core blocks” were still teacher‑driven (20‑minute bursts, 5‑minute breaks, rinse, repeat), but focused on students engaged in exercises with rapid feedback (not lectures). Afternoon workshops covered “life skills” like how to give and receive feedback or public speaking. I have not seen academic data from this time period, but when I spoke to Chris Locke, head of Alpha’s high school (which launched around 2020), he told me the kids coming into his 9th grade program were “fine,” academically – it was their life skills, confidence, and ability to engage with adults and their peers were exceptional. At this stage no AI, no dashboard, no 2x learning, no portal — just better ratios and focused pacing and the result was well balanced kids who were enjoying their education experience (even if they were unexceptional academically). 2020 – 2022 | Platform Era Begins Somewhere along the way Liemandt hired a small engineering team to stitch together edtech learning tools. Many schools use tools like iXL, Beast Academy and Amira. Those tools fit in well with the 2-hour structured approach Alpha was using. The “platform” Liemandt’s team built was meant as a tool to free up guide time so that students could be more self-directed. The dev team stitched together the preferred off‑the‑shelf apps behind a single login, and built out tracking and dashboards so guides (and students) could easily see how they were progressing. This also gave the curriculum team (there was a curriculum team now) data to understand where students were spending their time, what tools were working, and which weren’t as effective. The Alpha Portal was born. Not only did it increase efficiency, it provided data to iterate with. Chris Locke saw the curve change incrementally: each new cohort of ninth‑graders under the new tech-enabled learning platform came in a little stronger academically. The “life skills” were now being matched by the “academic skills”. 2022 | Expansion and Iteration By having access to Alpha kids post-graduation in the high school, Locke could send feedback back to the elementary school.The kids coming out of the new program were now killing it academically on Math, Language, and Science, but they were still weak on things like History and Geography. He fed that type of information back to the curriculum designers, who iterated and improved the program. Soon, in addition to the core platform that directed students to third-party tools, the tech team was building proprietary “Alpha” tools themselves. The flagship of the in-house tools was “AlphaReads”. AlphaReads requires students to read progressively more complicated passages, followed by answering reading comprehension questions. In addition to helping the kids improve reading skills, Alpha uses it to push types of content. Instead of classes in history, geography, economics and political science, some of the reading passages will cover that material (in addition to learning how to read and understand Shakespeare and Proust). The success of the 2-hour learning platform was giving the Alpha founders confidence. Liemandt in particular wanted to see if the program had legs beyond the elite group of students being educated in Austin. Alpha’s first external test in August 2022 in Brownsville, TX – a small community on the Mexico border with less than half the per capita income of Austin. SpaceX had recently launched Starbase in Brownsville in 2014 and the employees there were not happy with the existing school options. Someone at SpaceX approached Alpha and asked if they could launch a new campus for their employees. It is unclear if any money changed hands, but when Alpha launched their Brownsville campus (available to SpaceX employees and any other locals who are interested) tuition was only $10,000 (vs $40,000 at the main Austin campus); incoming students trailed national academic standards by over a year. But after nine months on the Alpha program the first cohort of students had caught up and surpassed the national average, and they kept accelerating, achieving an average learning velocity of ~2× the national average (see section four for what that means). Brownsville was Alpha’s attempt to show that their model wasn’t just rich‑kid selection effects. Spring 2024 | Field Pilots & Ukraine Trip Alpha tuition is high for the Austin area ($40,000 vs average private school ~$10,000-$15,000), but unlike most private schools tuition is all-inclusive. There are no extra fees for computers or field trips. There are no silent auctions or appeals for donations. This “no extra fees” allows the school to do some pretty ridiculous things. In the first half of 2024 Alpha sent a group of students to Poland to help launch a 2-hour learning pilot among Ukrainian refugees. Students did not pay to go on the trip. But students also did not have a “right” to go on the trip. They had to earn it. In addition to being on top of academic and non-academic expectations, students who wanted to participate had to learn basic Ukrainian so they could interact with the students in Poland they were meant to be helping. By not linking the opportunity to payment, the school could instead link it to behavior and achievement. This year a group of kids who learned to sail during the school year are going on a sailing trip through the Caribbean – for no additional fees to the parents. I also heard that around this time Alpha began testing the 2-hour learning platform at a facility for juvenile delinquents in Florida. I heard that from one individual who was not directly involved and I have not found any written documentation on it, so unclear if it worked, it was a one off, or if it even happened. But it fits into the pattern of Alpha at this stage: “We know this program works for a specific type of kid. Let’s find out how broadly it is applicable. Can it work for everyone? Is it the solution for learning and education for the world?” Fall 2024 | “Pick‑Your‑Afternoon” Specialist Schools MacKenzie told me that there was consensus among the current parents of Alpha that the 2-hour learning program was exceptional and was making a huge difference with their kids. Their kids were all learning at breathtaking speed in a very condensed period of time. But there was NOT consensus about what the kids should be doing in the other 22-hours of the day. Some parents wanted to utilize the platform’s capabilities to go even faster. Some wanted their kids to just chill out and enjoy the rest of their day – let kids be kids. Others wanted their kids to use the freed up time to do sports, or study music. It was clear to her that “learn more faster in a short period of time” was a universal desire. But beyond that it was unclear what the “right” solution for the rest of her program was. You can make the morning ultra-personalized, but if the goal of the afternoon is socialization that you are missing in the morning, you need to have some sort of alignment on how to spend that afternoon. That challenge led to Alpha’s 2024 expansion into specialty schools. Three micro‑campuses opened August 2024: GT School (Georgetown, TX) — Alpha’s “Gifted and Talented” School. Higher admissions bar; higher academic expectations; Afternoon programming focused on excelling in “academic competitions” like chess, go, debate, public speaking, robotics, programming and Quiz Bowl.
Inline links: Boundless, Prospera, MacKenzie Price, Joe Liemandt, GT School
GT School (Georgetown, TX) — Alpha’s “Gifted and Talented” School. Higher admissions bar; higher academic expectations; Afternoon programming focused on excelling in “academic competitions” like chess, go, debate, public speaking, robotics, programming and Quiz Bowl.
Inline links: GT School
Quiz Bowl All of the GT Workshops are focused on a measurable, legible output. They don’t learn “public speaking”, they learn how to craft and deliver a speech and then submit the performance to the Moth to be judged by external parties. The school’s “100% Money Back guarantee” is that every student who attends will be in the top 1% academically and win at least one national academic competition (for kids who start in kindergarten they guarantee 1350+ SAT and 5s on APs by 8th grade). This past year four kids placed in the top-8 in a global debate with more than 1000 entries, and two kids are competing at national championships in chess and an academic bee respectively, but not national champions yet. The second part of the afternoon is roughly 45-minutes per day to work on individual “Check Charts”. Check Charts are an assigned series of tasks each student needs to complete before they can move to the next “level”. Levels are mostly broken into two-year cohorts of kids. Roughly: Learning Lab = Kindergarten and 1st grade
Inline links: 100% Money Back guarantee
publication bias1 mentions across 1 issues

publication bias is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between February 01, 2023 and February 01, 2023. The archive places it in contexts such as "stances, is publication bias". It most often appears alongside 2006 Ioannidis paper, ACTIV-6, Alexandros.

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publication bias
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1
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1
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February 01, 2023
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February 01, 2023
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Response To Alexandros Contra Me On Ivermectin
February 01, 2023 · Original source
I thought the most plausible explanation for the discrepancy was Dr. Avi Bitterman’s hypothesis (now written up here) that ivermectin worked for its official indication of treating parasitic worms. COVID is frequently treated with steroids, steroids prevent the immune system from fighting a common parasitic worm called Strongyloides, and sometimes people getting treated for COVID died of Strongyloides hyperinfection. Ivermectin could prevent these deaths, which would mean fewer deaths in the treatment group than the control group, which would look like ivermectin preventing deaths from COVID in high-parasite-load areas (like the tropics) but not low-parasite-load areas (like temperate zones). This explained some of the mortality results, with the other endpoints likely being because of publication bias.
Inline links: here
The control groups in high-worm-prevalence-area studies had no more deaths than in low-worm-prevalence-area studies. If the worms were killing people in the control groups (who ivermectin was then saving in the treatment groups) you would expect more deaths. You can find arguments for all these points at the link. (One additional thing Alexandros does that I really like: he compares the Strongyloides hypothesis - as an attempt to explain why these studies keep getting such different results - to other hypotheses. For example, studies in Latin America get negative results more often than others. This really feels like confronting the real question. He finds that Latin American studies do find lower efficacy for ivermectin than the other mostly Asian studies, and hypothesizes that this is because ivermectin is very popular in Latin America, the “control” group illicitly takes it without telling the researchers, and so these studies are inadvertantly comparing two ivermectin groups. This is another clever and elegant theory. Unfortunately, the recent spate of negative American studies sink it6. Still, I agree there is a strong geographic element here; worms are one possible explanation, but there are others - including the scientific culture in different countries. I appreciate Alexandros highlighting how much this is true.) I asked Dr. Bitterman for his thoughts. He reiterates that although steroids are one major cause of Strongyloides hyperinfection, another is eosinopenia, a decrease in the immune cells that fight parasites. COVID can cause eosinopenia directly, so just because a COVID patient didn’t get steroids, or was only on steroids for a short period, doesn’t prove that the patient couldn’t have had hyperinfection. On the mixing of different sources to get Strongyloides prevalence data, he said: As mentioned in the paper, when available we attempted to granulate by regional prevalence. This was often not possible because robust data did not available for a given country. Brazil is a large country (and multiple different studies in our analysis were in Brazil) with variability and Paula was a robust study. We decided to attempt to granulate instead of stacking the Brazil countries with the same prevalence even though they are in very different regions. His re-analysis is a crude one, and he often switches between using that analysis and the ecological model study. At the time of out paper's publication, the ecological model was not available. I offered to re-do the whole analysis with that study's raw data with a mutually agreed upon methodology, which we have not fully ironed down yet. On the long delay before hyperinfection kills: I don't think it happens in 1 or 2 weeks. But 3-4 weeks (within almost all study durations) is certainly not unheard of (again, without being treated). Even 1/3rd of the [untreated animals in a marmoset study Alexandros cites] died within the range of the study durations." On the more general argument: I have a higher credence of the effect modifier than he does. Perhaps the main thing I don't think he fully appreciates is just how few deaths need to be explained by this in order to substantially shift the RR. Even if this is the case for just a handful of control group deaths, the RR change is not trivial simply because of how low events the entire supposed benefit was in the first place. Furthermore, the new trials (ACTIV-6 400, ACTIV-6 600, COVID-OUT), while they all have very low mortality rates, all tip the needle in favor of the hypothesis. As expected, in the USA where the prevalence is near 0, all the deaths of those trials were in the ivermectin group (again, small event rates though). I could re-do the analysis with the new data even with his critiques of how he thinks it should be done (which is highly debatable) but I didn't end up doing it because at this point it would be an historical debate since the world has moved on from the topic. There are other points of course, there's quibbles line by line. I find Alexandros’ adjustment for Brazil somewhat convincing - not necessarily as a good adjustment, just in the sense that some adjustment needed to be done. I think the broader point is that results on the border of “statistical significance” often appear or go away depending on ambiguous decisions about coding single cases. Alexandros realizes this and includes a more gestalt style chart directly showing the correlation, which he says goes below the significance threshold when you recode the Brazilian studies. This chart seems to be missing some studies which might change its conclusions; it was made by a third party and Alexandros is going to get back to me with more information. Dr. Bitterman adds that more recent American studies strengthen his hypothesis. More discussion with Dr. Bitterman has also helped me better understand the context of this theory. Ivermectin does worst in studies of intermediate clinical endpoints: hospitalization, ICU admission, recovery time. It does best in studies of viral clearance rate and mortality. Viral clearance rate is a weak preclinical endpoint: not only is it especially susceptible to biases and file drawer effects, but it’s not that interesting unless it affects later clinical outcomes; many drugs change secondary endpoints but fail to change the things we care. Mortality is (usually) a strong and important endpoint; apparent positive results of ivermectin here require an explanation. The Strongyloides hypothesis tries to provide it. But I erred on my earlier post by holding it up as “the” explanation for a large and heterogenous group of studies which were mostly looking at endpoints other than mortality, or as a counter to ivmmeta’s analysis which found positive results everywhere for everything through statistical incompetence. I think I implicitly believed a stronger version of the worm hypothesis - that even in places without literal Strongyloides literally killing you, some people had some parasitic worms that were holding them back, ivermectin killed those worms, and that made them healthier overall and better able to deal with COVID. But nobody has asserted or defended that hypothesis and there’s no evidence for it. When I asked Dr. Bitterman, he pointed out that the opposite was at least as credible: parasitic worms depress the immune system, but immune overreaction is a major cause of death in COVID, so getting rid of them could make things worse rather than better. The original post should have explained this hypothesis better, devoted less emphasis to it, and focused more on publication bias and other issues that could explain the overall result. In some cases, these issues would have shed more light on the mortality statistics too. On my original post, I wrote: Parasitic worms are a significant confounder in some ivermectin studies, such that they made them get a positive result even when honest and methodologically sound: 50% confidence In retrospect this is framed too weakly - “significant” in “some” studies is compatible with irrelevant overall. Still, sticking to the spirit of what I meant, I think I would lower this guess to more like 35% now , and lower my overall estimate of how much of the mystery it explains even further. I’m not an expert on this, you shouldn’t care about my exact probability, and I’m only mentioning it to communicate clearly and try to hold myself accountable. V. Publication Bias Alexandros has various arguments against funnel plots in general, and Dr. Bitterman’s funnel plot in particular. Some of these arguments are reasonable, but taken together they would discredit 95 - 100% of all funnel plots everywhere. Trying to destroy the whole institution of funnel plots just because one of them disagrees with your hypothesis is . . . honestly a move I have to respect. I agree that these provide Bayesian evidence, rather than 100% irrefutable evidence, of publication bias, and need to be considered in the context of everything else going on. After doing that, I still think they’re publication bias. That makes publication bias more important. In the original post, I included this funnel plot from Dr. Bitterman: In case you haven’t seen one of these before: this plots how big an effect the study found (horizontal axis) against study size (vertical axis). Studies that find ivermectin had no effect are at the center (RR = 1), studies that find a strong curative effect are to the left, studies that find a strong harmful effect are to the right. When all studies are good, we have no reason to expect a correlation between study size and ivermectin efficacy - any deviations from the true effect should be random. This would look like a triangle centered around the true effect of the drug, with an equal number of studies on both sides. When there is a lot of publication bias, we should expect that small studies get published only if they find exciting results, and big studies get published regardless (because a lot of work went into them, someone will want to publish them, and journals will accept them regardless of how exciting they are). So here you would expect to see big studies around zero, and an asymmetric tail of smaller studies heading in the more-exciting direction. This is what we see on Dr. Bitterman’s plot, suggesting strong publication bias for ivermectin results. Alexandros’ full counterargument is here. Trying to sum it up: Funnel plots can sometimes look deceptive, or be misreported, and are generally suspect.
Inline links: 6, studies of intermediate clinical endpoints, https://substackcdn.com/image/fetch/$s_!rlgm!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F174e569d-8a2c-4c11-a2ff-d355f4bce5b1_1200x808.jpeg, here
In case you haven’t seen one of these before: this plots how big an effect the study found (horizontal axis) against study size (vertical axis). Studies that find ivermectin had no effect are at the center (RR = 1), studies that find a strong curative effect are to the left, studies that find a strong harmful effect are to the right. When all studies are good, we have no reason to expect a correlation between study size and ivermectin efficacy - any deviations from the true effect should be random. This would look like a triangle centered around the true effect of the drug, with an equal number of studies on both sides. When there is a lot of publication bias, we should expect that small studies get published only if they find exciting results, and big studies get published regardless (because a lot of work went into them, someone will want to publish them, and journals will accept them regardless of how exciting they are). So here you would expect to see big studies around zero, and an asymmetric tail of smaller studies heading in the more-exciting direction. This is what we see on Dr. Bitterman’s plot, suggesting strong publication bias for ivermectin results. Alexandros’ full counterargument is here. Trying to sum it up: Funnel plots can sometimes look deceptive, or be misreported, and are generally suspect.
Inline links: here
Puck1 mentions across 1 issues

Puck is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between May 23, 2024 and May 23, 2024. The archive places it in contexts such as "rubber object hit by hockey players? (Puck)". It most often appears alongside 1984, 1984 Calendar Meme, ACX.

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Puck
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A Theoretical "Case Against Education"
May 23, 2024 · Original source
What is the name of the rubber object hit by hockey players? (Puck, 89%)
Pulitzer Prize1 mentions across 1 issues

Pulitzer Prize is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between May 15, 2025 and May 15, 2025. The archive places it in contexts such as "they are all recent Pulitzer Prize winners". It most often appears alongside ACX survey, Amazon, Barbara Kingsolver.

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Pulitzer Prize
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Book Review: Selfish Reasons To Have More Kids
May 15, 2025 · Original source
Most of our students are functionally illiterate. This is not a joke. By “functionally illiterate” I mean “unable to read and comprehend adult novels by people like Barbara Kingsolver, Colson Whitehead, and Richard Powers.” I picked those three authors because they are all recent Pulitzer Prize winners, an objective standard of “serious adult novel.” Furthermore, I’ve read them all and can testify that they are brilliant, captivating writers; we’re not talking about Finnegans Wake here. But at the same time they aren’t YA, romantasy, or Harry Potter either […]
punctuated equilibrium1 mentions across 1 issues

punctuated equilibrium is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between July 14, 2023 and July 14, 2023. The archive places it in contexts such as "punctuated equilibrium vs. gradualism". It most often appears alongside !Kung San, aboriginal people on the west coast of Canada, Adam Smith.

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punctuated equilibrium
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Your Book Review: The Educated Mind
July 14, 2023 · Original source
instead of giving the usual short definition of natural selection, a biology class could dip into the recent professional debates that have motivated specialists — things like selfish gene theory, multi-level section, punctuated equilibrium vs. gradualism
Punjabi truck drivers1 mentions across 1 issues

Punjabi truck drivers is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between October 13, 2022 and October 13, 2022. The archive places it in contexts such as "vibrant community of Punjabi truck drivers". It most often appears alongside 1996 Illegal Immigration Reform and Immigrant Responsibility Act, 21st Century Salon, ACX.

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Punjabi truck drivers
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Highlights From The Comments On The Central Valley
October 13, 2022 · Original source
I personally think the Valley is underrated and its diversity under-appreciated. This applies both to its cities and to its rural, ag-based communities. The stories of exploited and impoverished farm labor are all too true—“Factories in the Field” as Carey McWilliams famously described the situation back in Great Depression days. Yet there also are stories of upward mobility and cultural dynamism, such as the celebrated Masumoto and Thao family farms outside Fresno and the vibrant community of Punjabi truck drivers.
punk rock1 mentions across 1 issues

punk rock is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between August 19, 2022 and August 19, 2022. The archive places it in contexts such as "punk rock". It most often appears alongside 00s, 70s, 80s.

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punk rock
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Highlights From The Comments On Subcultures
August 19, 2022 · Original source
Is this post intended to chronicle the cycle of those subcultures that are clearly 'movements', or is it intended to cover subcultures in general? Because I can think of any number of garden variety subcultures (skateboarding in the 70s and 80s, punk rock, D&D guys, etc) that had/have significant cultural traction that don't obviously fit this model.
punktoj1 mentions across 1 issues

punktoj is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between February 03, 2022 and February 03, 2022. The archive places it in contexts such as "I want to kickstart a movement to test these ideas out. A movement called *punktoj*". It most often appears alongside 538, 55-gal drum, 750k horny men.

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punktoj
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ACX Grants ++: The First Half
February 03, 2022 · Original source
#1: A Movement To Fight Attention Hijacking It’s my assertion that we need to draw people’s attention to the methods marketers use to get us to buy stuff – to point out the techniques used in digital and physical environments. The trappings of an advanced economy have led us to create some persuasive methods of engagement. And while these have been used to subliminally guide us towards purchases, by drawing attention to them as a phenomenon, we can unlock new ways to use them for the greater good – for educational purposes, to encourage positive behaviours, for healthcare, mental wellbeing, and other challenges we face as part of what, Alvin and Heidi Toffler refer to as ‘the Third Wave’ of development. Won’t that denigrate the intent behind these techniques? Well… let’s be fair – advertisers have had it good for a long time. That said, does the fact we know what television commercials or online ads are trying to do, make us buy less stuff? Nope. While drawing attention certainly makes us more aware of the purpose of the medium used, it also leads us to greater transparency and an increased opportunity to mix media – for any purpose. Could the UI that made Facebook addictive be used to promote healthy eating? Could we re-engineer Gruen transfer for hospital appointments? Can Kansei design principles remove racial bias? I want to kickstart a movement to test these ideas out. A movement called *punktoj* Anyone game? Ping me: dave.barton@tbc.wtf
Purchase Fuzzies and Utilons Separately1 mentions across 1 issues

Purchase Fuzzies and Utilons Separately is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between January 11, 2024 and January 11, 2024. The archive places it in contexts such as "related: Purchase Fuzzies and Utilons Separately". It most often appears alongside ACX Grants, Africa, Amalgamated Kenyan Wells.

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Highlights From The Comments On Capitalism & Charity
January 11, 2024 · Original source
The counterargument is Nassim Taleb’s “barbell” idea (related: Purchase Fuzzies and Utilons Separately). If you’re trying to optimize two different goals (eg make money and do good), you’re better off doing half one and half the other, rather than putting all your chips in one fuzzy combination of both.
Inline links: Purchase Fuzzies and Utilons Separately
Pure Land1 mentions across 1 issues

Pure Land is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between May 04, 2022 and May 04, 2022. The archive places it in contexts such as "What about the Pure Land stuff? asks a guy in a beret". It most often appears alongside 1000, 1200, 1400.

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Pure Land
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Every Bay Area House Party
May 04, 2022 · Original source
She’s gathered a small audience now. “What about the Pure Land stuff?” asks a guy in a beret. “If you say the words Namu Amida Butsu ten times, then when you die Amida Buddha will pluck your soul from the aether and ensure it gets reborn in his heaven dimension. Still doesn’t sound very scientific to me.”
“Mmmmm, kind of? I was really into Zen in college. I would sit zazen for two, three hours every day. A few years after I graduated, I took the plunge and quit my job at Google to study a Zen monastery near Kanazawa. The first day I was there, the master said ‘This very world is the Pure Land, and each one of you is already enlightened.’ I was really relieved, because I’d thought I would have to stay at the monastery like ten, maybe twenty years to get enlightened. So I thanked him and went off to pack my stuff. He ran after me, asked ‘Where are you going?’ I said that honestly I wasn’t that into the Zen aesthetic and I was just there to get enlightened - but if I was already enlightened, then mission accomplished and I might as well go back to Google. I spent a couple days seeing Kanazawa, then flew home.”
Purim1 mentions across 1 issues

Purim is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between April 21, 2021 and April 21, 2021. The archive places it in contexts such as "We will wear costumes for Purim". It most often appears alongside Andes Mountains, Antiochan subgroup, Argentina.

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Purim
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April 21, 2021
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No, Really, Why Are So Many Christians In Colombia Converting To Orthodox Judaism?
April 21, 2021 · Original source
Shlomo pulled him gently to the side. I could not hear his words, but Baruj looked disappointed. He hesitated. Finally, he put the candy on the sidewalk. “We will wear costumes for Purim,” Shlomo promised. “This holiday is not ours.”
Puritan suffragettes1 mentions across 1 issues

Puritan suffragettes is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between August 09, 2023 and August 09, 2023. The archive places it in contexts such as "what the 19th century Puritan suffragettes were getting up to". It most often appears alongside @data_depot, @StefanFSchubert, AI Snake Oil blog.

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Puritan suffragettes
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Links For August 2023
August 09, 2023 · Original source
28: However much sex-and-relationship drama you have in your social movement, it doesn’t hold a candle to what the 19th century Puritan suffragettes were getting up to.
Inline links: what the 19th century Puritan suffragettes were getting up to
Puritanism1 mentions across 1 issues

Puritanism is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between May 12, 2021 and May 12, 2021. The archive places it in contexts such as "explore the fall of Puritanism in Massachussetts". It most often appears alongside 1950s, 1950s American consensus, 1990s.

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Puritanism
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May 12, 2021
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Theses On The Current Moment
May 12, 2021 · Original source
6. Somebody should explore the fall of Puritanism in Massachussetts
Massachussetts in 1692 may have been one of the most repressive societies ever to exist. Anyone who spoke out against it was burned as a witch or exiled. Fine, okay, point taken, don't speak out against Puritanism. But by the 1820s, Massachussetts was one of the most open societies in the world. The Puritan Church turned into the Unitarian Church (I swear this is true, the Unitarian Universalists are the direct descendants of the 1600 Puritans). Intellectuals like Ralph Waldo Emerson and Henry David Thoreau explored exciting new ideas like "what if Christianity sucked and the real religion was my headcanon of Hinduism I made up after learning three Sanskrit words?" How did this happen? I would love to read a book or a paper about it but I don't know of any.
Inline links: turned into the Unitarian Church
Purkinje tree1 mentions across 1 issues

Purkinje tree is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between October 01, 2025 and October 01, 2025. The archive places it in contexts such as "The “tree of life symbol” might be a Purkinje tree , an established entoptic phenomenon". It most often appears alongside 1910s Portugal, 1999 British eclipse, 2017 US eclipse.

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Purkinje tree
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October 01, 2025
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October 01, 2025
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The Fatima Sun Miracle: Much More Than You Wanted To Know
October 01, 2025 · Original source
(source) The swirling, colorful sun sounds like the miracle of Fatima. The “tree of life symbol” might be a Purkinje tree, an established entoptic phenomenon. As for the rest, your guess is as good as mine. For what it’s worth, evangelical Christians warn that Demons Enter By Sungazing. This could just be the evangelical Christian tendency to worry about demons being associated with every unusual spiritual practice. But those figures walking out of the lake will haunt my dreams. 6: And I Say, It’s All Right Here’s the most sensible story I can generate for the Sun Miracle of Fatima: There is some previously unknown optical illusion that potentially causes the sun to appear to change colors and spin. This phenomenon is rare and inconsistent, and usually appears only after someone has stared at the sun a very long time. This explains why it’s only reported in the wild by a few weird Redditors who stare at the sun on purpose every day. The appearance of this illusion is somehow modulated by cloud cover. In normal conditions (bright day, no clouds) it’s almost impossible to summon without long periods of sungazing. But when the sun is half-hidden by translucent clouds, the illusion happens much faster. This explains why the Fatima, Ghiaie, Benin City, Necedah, and Lubbock miracles - as well as some of the most impressive Medjugorje cases - all happened just after rain stopped and the clouds were just starting to clear. It also explains why Fatima witnesses say that the sun was “covered in gauze” or “blocked by smoked glass” or “had a diaphanous veil” or “looked like it was seen through a window”. It’s also why, during the most impressive instances of the miracle, people say they can stare at the sun without it being too bright or hurting their eyes. But like koro, the illusion is also modulated by expectations and social priming. Paying attention to the sun, expecting something weird to be there, is much more likely to generate the illusion than catching a casually glance of it. This explains why it is most common during Marian apparitions and other Catholic events full of people familiar with Fatima, and only very occasionally appears to weird Redditors who aren’t specifically looking for it. It also explains why Professors Messeen and Stöckl (who were specifically thinking about Fatima at the time) got better results than earlier scientists (who were observing without preconceptions). At Fatima, the basic illusion, the meteorologic conditions, and the social priming all came together to a point where 80%+ of the pilgrims saw the phenomenon quickly enough that they neither stopped looking nor perceived it as taking unreasonably long. The conditions lasted ten minutes, during which time the sun peeked out from behind the clouds three times; to people who had been staring at the (veiled) sun with their pupils dilated, this looked like the sun suddenly flaring up monstrously large and hurling itself towards Earth (and speculatively, maybe something similar is responsible for the changes in the Filipino video). A small number of mentally susceptible people, already in a vulnerable state because of this apparent miracle, influenced by a process similar to visual release hallucinations, saw additional visions, like the Virgin Mary or the Cross. Some distant witnesses remembered that someone had prophecied a nearby miracle for that day. Because they were not so distant as to have totally different meteorologic conditions, when they looked up at the sky trying to catch the miracle, they saw it too. After the miracle ended, the people who saw it were primed to see it again for the next few weeks - partly because they were looking at the sun expectantly, and partly because they were in a susceptible frame of mind (cf discussion of delusional parasitosis here, panic attacks here, or chronic pain here) - explaining Garrett’s claim that “now everyone sees [the sparkling rotations of the sun] many days and many times”. Even thinking about the miracle served as a form of priming, so further Marian devotions in Fatima and elsewhere became hotspots for miraculous activity. This theory avoids some of the pitfalls of its component parts: I previously said that entoptic phenomena / hallucinations / illusions couldn’t explain the miracle, because normal sungazers don’t report it. This new theory adds modulation by meteorologic conditions and social priming. Absent these factors, the miracle will only occur for a small fraction of sungazers after many minutes spent gazing (producing the scattered Reddit reports). Given these factors, it can occur en masse.
Inline links: source, a Purkinje tree, Demons Enter By Sungazing, here, here, here
Putinist1 mentions across 1 issues

Putinist is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between October 04, 2024 and October 04, 2024. The archive places it in contexts such as "slight Putinist resurrection-in-name-only"; "with a slight Putinist resurrection-in-name-only". It most often appears alongside 1880 - 1930 period, 1890s, 20th century.

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Putinist
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October 04, 2024
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Against The Cultural Christianity Argument
October 04, 2024 · Original source
But the Christian cultural package also fell apart and became the current post-Christian world. This wasn't just a one-time coincidence either. Protestantism gave way to modernism in Scandinavia, Germany, and the US. Catholicism gave way to modernism in Spain, Italy, and Latin America. Orthodoxy gave way to modernism in Greece, Eastern Europe, and Russia (with a slight Putinist resurrection-in-name-only which hardly seems to have produced a flourishing liberal society). Meanwhile in China, the local mix of Buddhism/Confucianism/Taoism gave way to modernism. In South East Asia, Buddhism gave way to modernism. Only 10% of Israeli Jews are ultra-Orthodox, and it would be lower if they didn't breed so fast. India is moderately Hindu but still noticeably modern. Even the Middle East is gradually becoming less Muslim.
PVF1 mentions across 1 issues

PVF is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between September 02, 2021 and September 02, 2021. The archive places it in contexts such as "median length of 80 for CFS/ME vs. 0 for PVF". It most often appears alongside 1DaySooner, AC&E, AcesoUnderGlass.

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PVF
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September 02, 2021
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September 02, 2021
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Long COVID: Much More Than You Wanted To Know
September 02, 2021 · Original source
...viral fatigue”. Using the weird measure of “days per year of followup with diagnosis” (I’m not sure I fully understand their reasoning for why this is good), they find a median length of 80 for CFS/ME vs. 0 for PVF (…huh?). Using the more comprehensible measure of percent who still complain of fatigue after 7-12 months, they find it’s 24% vs. 10% (which super contradicts the above...
Pythagorean Theorem1 mentions across 1 issues

Pythagorean Theorem is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between February 23, 2022 and February 23, 2022. The archive places it in contexts such as "There are 371 known proofs of the Pythagorean Theorem". It most often appears alongside AGI, AI Impacts, AIXI.

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Pythagorean Theorem
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February 23, 2022
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February 23, 2022
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Biological Anchors: A Trick That Might Or Might Not Work
February 23, 2022 · Original source
Their distribution looks a lot like Ajeya’s, and even has the same median, 2052 (though forecasters could have read Ajeya’s report). Katja Grace et al surveyed 352 AI experts, and they gave a median estimate of 2062 for an AI that could “outperform humans at all tasks” (though with many caveats and high sensitivity to question framing). This was before Ajeya’s report, so they definitely didn’t read it. So lots of Ajeya’s different methods and lots of other people presumably using different methodologies or no methodology at all, all converge on this same idea of 2050 give or take a decade or two. An optimist might say “The truth points to itself! There are 371 known proofs of the Pythagorean Theorem, and they all end up in the same place. That’s because no matter what methodology you use, if you use it well enough you get to the correct answer.” A pessimist might be more suspicious; we’ll return to this part later. FLOPS Alone Turn The Wheel Of History One more question: what if this is all bullshit? What if it’s an utterly useless total garbage steaming pile of grade A crap? Imagine a scientist in Victorian Britain, speculating on when humankind might invent ships that travel through space. He finds a natural anchor: the moon travels through space! He can observe things about the moon: for example, it is 220 miles in diameter (give or take an order of magnitude). So when humankind invents ships that are 220 miles in diameter, they can travel through space! Ships have certainly grown in size tremendously, from primitive kayaks to Roman triremes to Spanish galleons to the great ocean liners of the (Victorian) present. The AI forecasting organization AI Impacts actually has a whole report on historical ship size trends to prove an unrelated point about technological progress, so I didn’t even have to make this graph up. Suppose our Victorian scientist lived in 1858, right when the Great Eastern was launched. The trend line for ship size crossed 100m around 1843, and 200m in 1858, so doubling time is 15 years - but perhaps they notice this is going to be an outlier, so let’s round up a bit and say 18 years. The (one order of magnitude off estimate for the size of the) Moon is 350,000m, so you’d need ships to scale up by 350,000/200 = 1,750x before they’re as big as the Moon. That’s about 10.8 doublings, and a doubling time is 18 years, so we’ll get spaceships in . . . 2052 exactly. (fudging numbers to land where you want is actually fun and easy) SS Great Eastern, the extreme outlier large steamship from 1858. This has become sort of a mascot for quantitative technological progress forecasters. What is this scientist’s error? The big one is thinking that spaceship progress depends on some easily-measured quantity (size) instead of on fundamental advances (eg figuring out how rockets work). You can make the same accusation against Ajeya et al: you can have all the FLOPs in the world, but if you don’t understand how to make a machine think, your AI will be, well, a flop. Ajeya discusses this a bit on page 143 of her report. There is some sense in which FLOPs and knowing-what-you’re-doing trade of against each other. If you have literally no idea what you’re doing, you can sort of kind of re-run evolution until it comes up with something that looks good. If things are somehow even worse than that, you could always run AIXI, a hypothetical AI design guaranteed to get excellent results as long as you have infinite computation. You could run a Go engine by searching the entire branching tree structure of Go - you shouldn’t, and it would take a zillion times more compute than exists in the entire world, but you could. So in some sense what you’re doing, when you’re figuring out what you’re doing, is coming up with ways to do already-possible things more efficiently. But that’s just algorithmic progress, which Ajeya has already baked into her model. (our Victorian scientist: “As a reductio ad absurdum, you could always stand the ship on its end, and then climb up it to reach space. We’re just trying to make ships that are more efficient than that.”) Part II: Biology-Inspired AI Timelines: The Trick That Never Works Eliezer Yudkowsky presents a more subtle version of these kinds of objection in an essay called Biology-Inspired AI Timelines: The Trick That Never Works, published December 2021. Ajeya’s report is a 169-page collection of equations, graphs, and modeling assumptions. Yudkowsky’s rebuttal is a fictional dialogue between himself, younger versions of himself, famous AI scientists, and other bit players. At one point, a character called “Humbali” shows up begging Yudkowsky to be more humble, and Yudkowsky defeats him with devastating counterarguments. Still, he did found the field, so I guess everyone has to listen to him. He starts: in 1988, famous AI scientist Hans Moravec predicted human-level AI by 2010. He was using the same methodology as Ajeya: extrapolate how quickly processing power would grow (in FLOP/S), and see when it would match some estimate of the human brain. Moravec got the processing power almost exactly right (it hit his 2010 projection in 2008) and his human brain estimate pretty close (he says 10^13 FLOP/S, Ajeya says 10^15, this 2 OOM difference only delays things a few years), yet there was not human-level AI in 2010. What happened? Ajeya's answer could be: Moravec didn't realize that, in the modern ML paradigm, any given size of program requires a much bigger program to train. Ajeya, who has a 35-year advantage on Moravec, estimates approximately the same power for the finished program (10^16 vs. 10^13 FLOP/S) but says that training the 10^16 FLOP/S program will require 10^33ish FLOPs. Eliezer agrees as far as it goes, but says this points to a much deeper failure mode, which was that Moravec had no idea what he was doing. He was assuming processing power of human brain = processing power of computer necessary for AGI. Why? The human brain consumes around 20 watts of power. Can we thereby conclude that an AGI should consume around 20 watts of power, and that, when technology advances to the point of being able to supply around 20 watts of power to computers, we'll get AGI? […] You say that AIs consume energy in a very different way from brains? Well, they'll also consume computations in a very different way from brains! The only difference between these two cases is that you know something about how humans eat food and break it down in their stomachs and convert it into ATP that gets consumed by neurons to pump ions back out of dendrites and axons, while computer chips consume electricity whose flow gets interrupted by transistors to transmit information. Since you know anything whatsoever about how AGIs and humans consume energy, you can see that the consumption is so vastly different as to obviate all comparisons entirely. You are ignorant of how the brain consumes computation, you are ignorant of how the first AGIs built would consume computation, but "an unknown key does not open an unknown lock" and these two ignorant distributions should not assert much internal correlation between them. Cars don’t move by contracting their leg muscles and planes don’t fly by flapping their wings like birds. Telescopes do form images the same way as the lenses in our eyes, but differ by so many orders of magnitude in every important way that they defy comparison. Why should AI be different? You have to use some specific algorithm when you’re creating AI; why should we expect it to be anywhere near the same efficiency as the ones Nature uses in our brains? The same is true for arguments from evolution, eg Ajeya’s Evolutionary Anchor, ie “it took evolution 10^43 FLOPs of computation to evolve the human brain so maybe that will be the training cost”. AI scientists sitting in labs trying to figure things out, and nematodes getting eaten by other nematodes, are such different methods for designing things that it’s crazy to use one as an estimate for the other. Algorithmic Progress vs. Algorithmic Paradigm Shifts This post is a dialogue, so (Eliezer’s hypothetical model of) OpenPhil gets a chance to respond. They object: this is why we put a term for algorithmic progress in our model. The model isn’t very sensitive to changes in that term. If you want you can set it to some kind of crazy high value and see what happens, but you can’t say we didn’t consider it. OpenPhil: We did already consider that and try to take it into account: our model already includes a parameter for how algorithmic progress reduces hardware requirements. It's not easy to graph as exactly as Moore's Law, as you say, but our best-guess estimate is that compute costs halve every 2-3 years […] Eliezer: The makers of AGI aren't going to be doing 10,000,000,000,000 rounds of gradient descent, on entire brain-sized 300,000,000,000,000-parameter models, algorithmically faster than today. They're going to get to AGI via some route that you don't know how to take, at least if it happens in 2040. If it happens in 2025, it may be via a route that some modern researchers do know how to take, but in this case, of course, your model was also wrong. They're not going to be taking your default-imagined approach algorithmically faster, they're going to be taking an algorithmically different approach that eats computing power in a different way than you imagine it being consumed. OpenPhil: Shouldn't that just be folded into our estimate of how the computation required to accomplish a fixed task decreases by half every 2-3 years due to better algorithms? Eliezer: Backtesting this viewpoint on the previous history of computer science, it seems to me to assert that it should be possible to: Train a pre-Transformer RNN/CNN-based model, not using any other techniques invented after 2017, to GPT-2 levels of performance, using only around 2x as much compute as GPT-2;
Inline links: surveyed 352 AI experts, https://substackcdn.com/image/fetch/$s_!JxQ5!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2Fceba6aa0-dbde-41ca-805e-01af4fac9324_769x336.png, a whole report on historical ship size trends, https://substackcdn.com/image/fetch/$s_!PRDj!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2Fde3d97f4-afca-45c4-9ed2-521cd25041df_460x262.jpeg, AIXI, Biology-Inspired AI Timelines: The Trick That Never Works
Python1 mentions across 1 issues

Python is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between December 22, 2023 and December 22, 2023. The archive places it in contexts such as "Google programmers who were taught Python by their fathers". It most often appears alongside ACX, Alexey Guzey, America.

Reference entry
Python
Mention count
1
Issue count
1
First seen
December 22, 2023
Last seen
December 22, 2023
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In The Long Run, We're All Dad
December 22, 2023 · Original source
Parents are supposed to teach their children the skills they need to navigate the world. This already feels somewhat obsolete - where are the Google programmers who were taught Python by their fathers, or the Instagram influencers who learned content creation on their mother’s knee? Soon it will be completely hopeless. Where we’re going there are no roads. You’ll have to figure it out by yourself. If I am to pass on anything of value to you, it can only be the ultimate power, the technique that forms all other techniques.
Inline links: the ultimate power
Python script1 mentions across 1 issues

Python script is a recurring concept in the Astral Codex Ten archive, appearing 1 times across 1 issues between September 18, 2023 and September 18, 2023. The archive places it in contexts such as "didn't even comprehend what is Python script". It most often appears alongside 787, adderallposting, ADL.

Reference entry
Python script
Mention count
1
Issue count
1
First seen
September 18, 2023
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September 18, 2023
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Highlights From The Comments On Elon Musk
September 18, 2023 · Original source
I seriously dropped my estimation after the Python script saga when allegedly AI-interested guy and former programmer didn't even comprehend what is Python script
Inline links: the Python script saga