CRISPR
Article
CRISPR is a recurring concept in the Astral Codex Ten archive, appearing 4 times across 4 issues between March 13, 2022 and July 24, 2024. The archive places it in contexts such as “expert in genetic editing (CRISPR etc.)”; “developed techniques to activate these genes with CRISPR”; “That leaves good old CRISPR. It’s illegal to CRISPR humans”. It most often appears alongside Congress, effective altruist movement, India.
Metadata
- Category: Concepts
- Mention count: 4
- Issue count: 4
- First seen: March 13, 2022
- Last seen: July 24, 2024
Appears In
Related Pages
-
- Congress (2 shared issues)
-
- effective altruist movement (2 shared issues)
-
- India (2 shared issues)
-
- London (2 shared issues)
-
- Metaculus (2 shared issues)
-
- 1DaySooner (1 shared issues)
-
- @the_megabase (1 shared issues)
-
- A Pan-Species Welfare State (1 shared issues)
-
- Abigail Shrier (1 shared issues)
-
- acanthamoeba keratitis (1 shared issues)
-
- ACX (1 shared issues)
-
- ACX Grantees (1 shared issues)
External Links
Source Context
Recovered passages from the original issue text. When the raw archive preserved outbound links inside the source passage, they are listed directly under the quote.
Spellcheck Health is looking for an expert in genetic editing (CRISPR etc.) to ask questions of, and possibly join their startup project. Looking for practical expertise with modern techniques, especially with CRISPR variants that can handle multiple long edits. Deep interest in human gene therapy for curative, longevity, and general optimization purposes a huge plus. Please email Michael at spellcheckhealth@icloud.com if interested.
24: In Vitro Gametogenesis Startup (9/10) Jeff Hsu says that his startup, Ivy Natal, has identified genes involved in meiosis and developed techniques to activate these genes with CRISPR. The next steps are to test the process to see if it induces meiosis and causes recombination events, and to test transfer of post-meiotic DNA to a donor egg.
Inline links: Ivy Natal
26: M’s CRISPR Spellchecking Project (?/10) The team continue not to want me to release details on this, sorry.
That leaves good old CRISPR. It’s illegal to CRISPR humans, and you’d have to do it at the embryo stage anyway. But it’s legal and practical to CRISPR animals. If you could CRISPR something like FAAH-OUT into cows, chickens, etc, you could create breeds of animal that don’t suffer. They think farms would go for it - non-suffering livestock isn’t just good press, it’s also healthier and (potentially) produces tastier meat. Then vegans could continue fighting for factory farming abolition as usual. But it wouldn’t be quite as desperate, and there wouldn’t be as many casualties along the way.
So Marcin’s current plan is to investigate CRISPR and suffering-free animals. Then, once his team has done something about animal welfare, he’ll circle back to humans with more resources and try to figure something out.
Neither the minicircles nor CRISPR are drugs, so they wouldn’t be expected to have any similar problems.
14: Arc Institute (Patrick Collison et al’s biotech research lab) claims to have discovered a gene editing method which is safer and more precise than CRISPR (Nature paper, Twitter discussion).
Inline links: Nature, Twitter discussion