Astral Codex Ten

People: Z

225 min read

People: Z

Writers, artists, hosts, DJs, filmmakers, and recurring characters across the archive. This section collects the Z slice of the category index.

Reference Index

Use the title to open the reference entry. Use the caret to expand a compact inline dossier with source context, issue trail, related pages, and outbound links.

Zvi30 mentions across 30 issues

Zvi is a recurring person in the Astral Codex Ten archive, appearing 30 times across 30 issues between February 05, 2021 and February 05, 2026. The archive places it in contexts such as "One, Zvi would learn to play politics as adroitly as the current Director"; "Two, Zvi would offend enough people that they would pressure Biden to fire him"; "Obviously the best case scenario would be that Zvi or whoever was the expert". It most often appears alongside Metaculus, Google, Twitter.

Article page
Zvi
Mention count
30
Issue count
30
First seen
February 05, 2021
Last seen
February 05, 2026
Outbound links
Issue trail
Related pages
Source context
WebMD, And The Tragedy Of Legible Expertise
February 05, 2021 · Original source
Joe Biden can't appoint Zvi as CDC Director, at least not usefully. If Biden appointed Zvi as Director one of three things would happen. One, Zvi would learn to play politics as adroitly as the current Director, and lose his advantage over her. Two, Zvi would offend enough people that they would pressure Biden to fire him. Or three, Zvi would offend people, Biden would offend people by not firing Zvi, and eventually Biden would fall beneath some necessary threshold of support and not be able to be an effective President. I'm not saying that just appointing Zvi would inevitably get Biden impeached. I'm saying Biden has a certain amount of slack, given how many people he needs to keep happy in order to govern effectively, and appointing Zvi as CDC Director would use up so much of that slack that he couldn't do other equally useful things later without becoming ineffective and likely to lose reelection.
Journalism and Legible Expertise
February 07, 2021 · Original source
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Mantic Monday: Judging April COVID Predictions
February 23, 2021 · Original source
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Mantic Monday: Scoring Rule Controversy
March 01, 2021 · Original source
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When Will The FDA Approve Paxlovid?
November 23, 2021 · Original source
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Open Thread 203
December 19, 2021 · Original source
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Open Thread 205
January 03, 2022 · Original source
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Grading My 2021 Predictions
January 24, 2022 · Original source
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Predictions For 2022
February 01, 2022 · Original source
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Mantic Monday: Ukraine Cube Manifold
February 14, 2022 · Original source
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Ukraine Warcasting
March 01, 2022 · Original source
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Your Book Review: The Internationalists
July 01, 2022 · Original source
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Highlights From The Comments On Criticism Of Criticism Of Criticism
July 28, 2022 · Original source
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2023 Prediction Contest
December 16, 2022 · Original source
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Prediction Market FAQ
December 20, 2022 · Original source
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Open Thread 257
January 01, 2023 · Original source
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Links For March 2023
March 10, 2023 · Original source
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23
August 28, 2023 · Original source
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Open Thread 293
September 11, 2023 · Original source
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23
December 05, 2023 · Original source
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Book Review: Cyropaedia
January 10, 2024 · Original source
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Links For February 2024
February 29, 2024 · Original source
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Zvi on California's AI Bill
May 08, 2024 · Original source
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Links for May 2024
May 29, 2024 · Original source
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Links For December 2024
December 17, 2024 · Original source
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Deliberative Alignment, And The Spec
February 12, 2025 · Original source
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Open Thread 383
May 26, 2025 · Original source
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Links For September 2025
September 04, 2025 · Original source
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Open Thread 418
January 26, 2026 · Original source
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Links For February 2026
February 05, 2026 · Original source
No direct inline source block was recovered for this mention.
Zach Stein-Perlman5 mentions across 5 issues

Zach Stein-Perlman is a recurring person in the Astral Codex Ten archive, appearing 5 times across 5 issues between January 24, 2023 and March 13, 2025. The archive places it in contexts such as "8th: Zach Stein-Perlman. Zach entered under the pseudonym"; "Zach Stein-Perlman writes"; "Zach Stein-Perlman’s favorite AI governance research this year". It most often appears alongside OpenAI, Amazon, FDA.

Article page
Zach Stein-Perlman
Mention count
5
Issue count
5
First seen
January 24, 2023
Last seen
March 13, 2025
Outbound links
Issue trail
Related pages
Source context
Who Predicted 2022?
January 24, 2023 · Original source
8th: Zach Stein-Perlman. Zach entered under the pseudonym “My expected score is slightly worse than it would be if I always gave my true probabilities. I mention this in case you want to exclude me from analysis for that reason. (The form says "there is no strategic advantage to putting anything other than your honest predictions for each event", but this is totally false: I don't care about expected score, just probability of doing very well. If Scott had said to be honest, I would have, but instead he said "The winner will get eternal glory" so I'm lazily* maximizing winning probability. *If the universe was at stake, I would consider other tactics, but it's not, so I'm just being overconfident”, but I was able to figure out who he was from the email address. Zach is a forecaster and research analyst at AI Impacts, a nonprofit (founded by my ex-girlfriend) that tries to predict the future course of AI.
Inline links: AI Impacts
Highlights From The Comments On IRBs
April 17, 2023 · Original source
Finally, most of the surveys in question are just a series of basic psychology scales or tasks both the worker and average SSC reader are very familiar with. I suspect many of them are administered by students as practice rather than 'serious' research. As the other poster said, rejected HITs are just any task the requestor declines for any reason. A worker's acceptance rate is extremely important - one of the few pieces of advice Amazon seems to give requestors is to filter for 98% or 99% acceptance rate. It's probably pretty reasonable for surveys - if you can't get 99 out of 100 of those filled out acceptably (assuming good faith by the requestors), maybe you should be filtered. It's also worth noting that Amazon makes communication difficult, and that rejected HITs can only be reversed for like a month - after that, they're permanently on your record. It's also probably worth restating: if a worker goes below the high 90s, they'll have access to fewer tasks, likely from less reputable requestors, and they'll need to do 100 of these to offset every rejection. And the worker is at much greater risk of being dug deeper into that hole by requestors rejecting their work in bad faith with no recourse - part of why surveys are popular is because the IRB can bludgeon requestors into accountability. Most of the surveys in question are also are the crumbs that filter through the grasping pedipalps of the hordes of workers (and their scripts). If people are seriously using MTurk to monetize their time, they're likely looking for 'batch HITs' - the sort of thing where there's hundreds or thousands of tasks that can be quickly repeated (moderating images, 3 cents for a sentiment analysis, a couple quarters to outline a car in an image, etc.) Of course, this mana from heaven rarely lasts long, and the worker always takes a risk - 'if I do 100 of these, and this is an unscrupulous requestor, well - I better have ten thousand accepted HITs under my belt.' That's why workers are so protective of their acceptance rate. Back to surveys - again as the other poster replied, most of what the average MTurk worker will see is probably a psychology study questionnaire with a series of whatever common scales, attention checks, and other tricks the worker has probably seen at least dozens if not hundreds of times by now. They often pay Amazon's princely sum of about 10 cents per (expected) minute - based on the minimum wage in whatever benighted 00s year Amazon Mechanical Turk launched. Anecdotally, it also seems like a lot of these are from students - probably just practice research by someone who likely has less experience with the platform than the worker themselves. The problem the requestor has - at least as of ~2018 - is that there is a lot of fraud with foreign workers getting access to MTurk accounts and submitting totally garbo data, often very quickly. Based purely on a 'time to complete' metric, this is hard to distinguish from a legit worker who has filled out hundreds of these and is looking to maximize how many pennies they get for their minutes. It also wasn't uncommon for workers to 'cook' such a survey - letting it sit at the end screen before submitting - just to avoid getting pinged for finishing it quickly. As for how this all ties back into Institutional Review Boards - well, yeah, griping to the IRB is often the MTurk worker's only recourse. Amazon just doesn't care, and as I recall a lot of requestors don't even know workers can contact them - and as mentioned there's a narrow time window to discuss rejected HITs before they become permanent. On the other hand, in a lot of cases this is basically a reddit mob complaining that a student doling out dimes screwed up their understanding of MTurk's arcane inner workings, and that's in the case that the workers aren't actually trying to defraud them for said dimes. 5. Comments About Regulation, Liability, and Vetocracy CatCube writes: I think the fundamental problem is that you cannot separate the ability to make a decision from the ability to make a *wrong* decision. However, our society--pushed by the regulator/lawyer/journalist/administrator axis you discuss--tries to use detailed written rules to prevent wrong decisions from being made. But, because of the decision/wrong decision inseparability thing, the consequences are that nobody has the ability to make a decision. This is ultimately a political question. It's not wrong, precisely, or right either. It's a question of value tradeoffs. Any constraint you put on a course of action is necessarily something that you value more than the action, but this isn't something people like to admit or hear voiced aloud. If you say, "We want to make sure that no infrastructure project will drive a species to extinction", then you are saying that's more important than building infrastructure. Which can be a defensible decision! But if you keep adding stuff--we need to make sure we're not burdening certain races, we need to make sure we're getting input from each neighborhood nearby, etc.--you can eventually end up overconstraining the problem, where there turns out to be no viable path forward for a project. This is often a consequence of the detailed rules to prevent wrong decisions. But because we can't admit that we're valuing things more than building stuff (or doing medical research, I guess?), we as a society just end up sitting and stewing about how we seemingly can't do anything anymore. We need to either: 1) admit we're fine with crumbling infrastructure, so long as we don't have any environmental, social, etc., impacts; or 2) decide which of those are less important and streamline the rules, admitting that sometimes the people who are thus able to make a decision are going to screw it up and do stuff we ultimately won't like. Darwin on why safetyism expanded just as the neoliberals were trying to decrease government regulation: Without the excuse of 'we were following all of the very strict and explicit regulations, so the bad thing that happened was a freak accident and not our fault' to rely on, companies had to take safety and caution and liability limitation and PR management into their own hands in a much more serious way. And without the confidence in very strict and explicit regulations to limit the bad things companies might do, and without democratically-elected regulators as a means to bring complaint and affect change, we became much more focused on seeking remedy for corporate malfeasance by suing companies into oblivion and destroying them in the court of public opinion. Basically, government actually *can* do useful things, as it turns out. One of the useful things it can do is be a third party to a dispute between two people or entities, such as 'corporations' and 'citizens', and use it's power to legibly and credibly ensure cooperation by explicitly specifying what will be considered defection and then punishing it harshly. This actually allows the two parties, which might otherwise be in conflict, to trust each other much more and cooperate much better, because their incentives have been shifted by a third party to make defection more costly. Without government playing that role, you can fall back into bad equilibrium of distrust and warring, which in this case might look like a wary populace ready to sue and decry at the slightest excuse, and paranoid corporations going overboard on caution and PR to shield from that. Meadow Freckle writes: Why can’t you sue an IRB for killing people for blocking research? You can clearly at least sometimes activist them into changing course. But their behavior seems sue-worthy in these examples, and completely irresponsible. We have negligence laws in other areas. Is there an airtight legal case that they’re beyond suing, or is it just that nobody’s tried? I don’t know, and this seems like an important question. And Donald writes: Why do we need special rules for medicine? The law has rules about what dangerous activities people are allowed to consent to, for example in the context of dangerous sports or dangerous jobs. Criminal and civil trials in this context seem to be a fairly functional system. If Doctors do bad things, they can stand in the accused box in court and get charged with assault or murder, with the same standards applied as are applied to everyone else. If there need to be exceptions, they should be exceptions of the form "doctors have special permission to do X". I do want to slightly defend something IRB-like here. When a doctor asks you to be part of a study, they’re implicitly promising that they did their homework, this is a valuable thing to study, and that there’s no obvious reason it should be extremely unsafe. As a patient (who may be uneducated) you have no way of knowing whether or not this promise is true. Every so often, someone does everything right, and something goes wrong anyway. A drug that everyone reasonably thought would be safe and effective turns out to have unpredictable side effects - this is part of why we have to do studies in the first place. If every time this happened, a doctor had to stand trial for assault/murder, nobody would ever study new drugs. Trials are a crapshoot, and juries tend to rule against doctors on the grounds that the disabled/dead patient is very sympathetic and everyone knows doctors/hospitals are rich and can give them infinite money as damages. There is no way for an average uneducated jury to distinguish between “doctor did their homework and got unlucky” and “doctor did an idiotic thing”. Either way, the prosecution can find “expert witnesses” to testify, for money, that you were an idiot and should have known the study would fail. In order to remove this risk, you need some standards for when a study is safe, so that if people sue you, you can say “I was following the standards and everyone else agreed with me that this was good” and then the lawsuit will fail. Right now those standards are “complied with an IRB”. This book is arguing that the IRB’s standards are too high, but we can’t cut the IRB out entirely without some kind of profound reform of the very concept of lawsuits, and I don’t know what that reform would look like. 6. Comments About The Act/Omission Distinction jumpingjacksplash writes: I think you've unintentionally elided two distinct points: first, that IRBs are wildly inefficient and often pointless within the prevailing legal-moral normative system (PLMNS); second, that IRBs are at odds with utilitarianism. Law in Anglo-Saxon countries, and most people's opinions, draw a huge distinction between harming someone and not helping them. If I cut you with a knife causing a small amount of blood loss and maybe a small scar, that's a serious crime because I have an obligation not to harm you. If I see a car hurtling towards you that you've got time to escape from if you notice it, but don't shout to warn you (even if I do this because I don't like you), then that's completely fine because I have no obligation to help you. This is the answer you'd get from both Christianity and Liberalism (in the old-fashioned/European sense of the term, cf. American Right-Libertarianism). Notably, in most Anglo-Saxon legal systems, you can't consent to be caused physical injury. Under PLMNS, researchers should always ask people if they consent to using their personal data in studies which are purely comparing data and don't change how someone will be treated. For anything that affects what medical treatment someone will or won't receive, you'd at least have to give them a full account of how their treatment would be different and what the risks of that are. If there's a real risk of killing someone, or permanently disabling them, you probably shouldn't be allowed to do the study even if all the participants give their informed consent. This isn't quite Hans Jonas' position, but it cashes out pretty similarly. That isn't to say the current IRB system works fine for PLMNS purposes; obviously there's a focus on matters that are simply irrelevant to anything anyone could be rationally concerned with. But if, for example, they were putting people on a different ventilator setting than they otherwise would, and that risked killing the patient, then that probably shouldn't be allowed; the fact that it might lead to the future survival of other, unconnected people isn't a relevant consideration, and nor is "the same number of people end up on each ventilator setting, who cares which ones it is" because under PLMNS individuals aren't fungible. Under utilitarianism, you'd probably still want some sort of oversight to eliminate pointless yet harmful experiments or reduce unnecessary harm, but it's not clear why subjects' consent would ever be a relevant concern; you might not want to tell them about the worst risks of a study, as this would upset them. The threshold would be really low, because any advance in medical science could potentially last for centuries and save vastly more people than the study would ever involve. The problem is, as is always the case for utilitarianism, this binds you to some pretty nasty stuff; I can't work out whether the Tuskegee experiment's findings have saved any lives, but Mengele's research has definitely saved more people than he killed, and I'd be surprised if that didn't apply to Unit 731 as well. The utilitarian IRB would presumably sign off on those. More interestingly, it might have to object to a study where everyone gives informed consent but the risk of serious harm to subjects is pretty high, and insist that it be done on people whose quality of life will be less affected if it goes wrong (or whose lower expected utility in the longer term makes their deaths less bad) such as prisoners or the disabled. The starting point to any ideal system has to be setting out what it's trying to achieve. Granted, if you wanted reform in the utilitarian direction, you probably wouldn't advocate a fully utilitarian system due to the tendency of the general public to recoil in horror. I want to stress how far we are away from “do experiments without patient’s consent” here - a much more common problem is that patients really want to be in experiments, and the system won’t allow it. This is most classic in studies on cancer, where patients really want access to experimental drugs and IRBs are constantly coming up with reasons not to give it to them. Jonas argued that all cancer studies should be banned because it’s impossible to consent when you’re desperate to survive, which isn’t the direction I would have taken that particular example in. But there are other examples - during COVID, lots of effective altruists stepped up to be in human challenge trials that would have gotten the vaccines tested faster, but the government wouldn’t allow them to participate. I would honestly be happy with a system that counts the harm of denying a patient’s ability to consent to an experiment they really want to be in as a negative, forget about any lives saved. And JDK writes: I haven't finished reading by felt compelled to comment on this: "the stricter IRB system in place since the '90s probably only prevents a single-digit number of deaths per decade, but causes tens of thousands more by preventing lifesaving studies." No. It does NOT "cause" deaths. We can't go down this weird path of imprecision about what "causing" means. I've been examining Ivan Illich, "Medical Nemesis" recently. By claiming IRBs which stop research ostensibly CAUSE death strikes me as cultural iatrogenesis masquerading as a cure for clinical iatrogenesis. […] "Might have been saved if" is not the same as "death was caused by". This seems to me to be a weird and overly metaphysical nitpick. Suppose a surgeon is operating on someone. In the process, they must clamp a blood vessel - this is completely safe for one minute, but if they leave it clamped more than one minute, the patient dies. They clamp it as usual, but I rush into the operating room and forceably restrain the surgeon and all the staff. The surgeon is unable to remove the clamp and the patient dies. I (and probably the legal system) would like to be able to say I caused the patient’s death in this scenario. But it sounds like JDK is saying I have to say the surgeon caused the patient's death and I was only tangentially involved. Here’s another example; suppose the US government bans all food production - farmers, hunters, fishermen, etc are forbidden from doing their jobs. After a few months, everyone starves to death. I might want to say something like “the US government’s ban on food production killed people”. But by JDK’s reasoning, this is wrong - the government merely prevented farmers and fishermen from saving people (by giving them food so they didn’t starve). I might want to say something like “Mao’s collective farming policy killed lots of people”. But since this is just a weaker version of hypothetical-Biden’s ban on food, by JDK’s reasoning I can’t do this. This seems contrary to common usage, common sense, and communicating information clearly. I have never heard any philosopher or dictionary suggest this, so what exactly is the argument? (JDK has a response here, but I didn’t find it especially enlightening) 7. Comments About The Applications For AI Metaphysiocrat writes: People have joked about applying NEPA review to AI capabilities research, but I wonder if some kind of IRB model might have legs (as part of a larger package of capabilities-slowing policy.) It’s embedded in research bureaucracies, we sort of know how to subject institutions to it, and so on. I can think of seven obvious reasons this wouldn’t work, but at this point I’m getting doomery enough that I feel like we may just have to throw every snowball we have at the train on the off chance one has stopping power. Zach Stein-Perlman writes: A colleague of mine is interested in 'IRBs for AI'-- he hasn't investigated it but has thought about IRB-y stuff in the context of takeaways for AI (https://wiki.aiimpacts.org/doku.php?id=responses_to_ai:technological_inevitability:incentivized_technologies_not_pursued:vaccine_challenge_trials). He's interested in people's takes on the topic. My take: my understanding is that the US can’t technically demand all doctors use IRBs. (Almost) al doctors use IRBs for a combination of a few reasons : The US government demands that everyone who receives federal funding use an IRB, and most doctors get some federal funding.
Inline links: writes, Darwin, writes, writes, writes, writes, has a response here, writes, writes, https://wiki.aiimpacts.org/doku.php?id=responses_to_ai:technological_inevitability:incentivized_technologies_not_pursued:vaccine_challenge_trials
Links For August 2023
August 09, 2023 · Original source
8: Zach Stein-Perlman’s favorite AI governance research this year. 9: The Chichijima incident was notable as a time when George H. W. Bush almost got eaten by cannibals. During WWII, nine American pilots were shot down over an island commanded by a crazy Japanese officer who ate his enemies' livers. Eight were captured and killed (and four of those were eaten), and Bush alone fled and survived. 10: El Salvador’s murder crackdown claims results of 90% decrease in homicides, 44% decrease in emigration to US, and 90% approval rating for president Nayyib Bukele (h/t Richard Hanania). 11: In an earlier set of comments, I ignorantly repeated a claim that Mother Teresa denied her patients painkillers because she thought suffering brought people closer to God. A commenter corrected me: painkillers were just generally in short supply in India during her era (more discussion here). 12: The record for longest time a plane has spent in the air without landing is 64 days, achieved by a Cessna in 1959. You can read the full story here, but the basic setup looked like this: 13: Fact check: was Elvis Jewish? Snopes says yes, but I’m more convinced by this argument for no. [update: commenter TheGenealogian agrees no] 14: Is GPT-4 getting worse? This isn’t absurd; some people claim OpenAI has simplified the model to cut costs (though OpenAI denies this). Matei Zaharia argues yes, but I’m more convinced by the AI Snake Oil blog’s argument for no (h/t Stuart Ritchie). 15: Vox has a good piece about AI company Anthropic. I would quibble that they’re not the only safety-focused or EA-affiliated org, and we have yet to see how truly safety-focused or altruistic any AI company can be while continuing to be an AI company. But granting that it’s all a matter of degree, I agree the degree seems pretty high for them. And NYT also has an Anthropic article. 16: Eliezer bets $150,000 to $1,000 against UFOs being aliens, and gives the same argument I would - it’s unlikely that any civilization advanced enough to travel through space would still be primitive enough to use macroscopic, biologically-piloted craft that sometimes crash. 17: More nails in the coffin of growth mindset. “When examining the highest-quality evidence (6 studies, N = 13,571), the effect was nonsignificant: d = 0.02, 95% CI = [−0.06, 0.10]. We conclude that apparent effects of growth mindset interventions on academic achievement are likely attributable to inadequate study design, reporting flaws, and bias.” I think the older, very-high-effect-size studies were clearly terrible, but I’d still like to look further into the newer, small-but-significant-effect-size-that-makes-a-difference-across-large-groups studies and how they went wrong. 18: Previous work showed that after adjusting for selection bias, “what college you go to doesn’t matter” for average earnings. I was always skeptical of this - are all those rich people sending their kids to Ivies for no reason? Now Chetty, Deming, and Friedman find that: Attending an Ivy-Plus college instead of the average highly selective public flagship institution increases students’ chances of reaching the top 1% of the earnings distribution by 60%, nearly doubles their chances of attending an elite graduate school, and triples their chances of working at a prestigious firm. Ivy-Plus colleges have much smaller causal effects on average earnings, reconciling our findings with prior work. One of the authors, David Deming, has a Substack here where he explains the study in more depth. Like everyone else, this study also finds that rich people are using “holistic admissions” and the de-emphasis of standardized testing to gain an advantage: H/T Nate Silver, who writes: “Not sure how you can look at this data, ostensibly be interested in either meritocracy or equality, and want to move away from standardized tests. It's the subjective measures that are most slanted in favor of the rich kids.” Cf. Erik Hoel. 19: From @data_depot: “In 2002, 48% of Americans said "the govt is run by a few big interests looking out for themselves." 52% said "it is run for the benefit of all people." In 2020, 84% said the govt is run by a few big interests. Only 16% said it is run for the benefit of all people.” Source seems to be here, which reveals 2002 was a local peak in trust in government; maybe because of post-9/11 unity, but even 2000 was 34%, much better than our current 16%. My first instinct is to attribute this to a rise in vulgar Marxism, in the sense of everyone (even conservatives) now being trained to think in terms of an elite class screwing over everyone else (cf my review of Manufacturing Consent). But there was a previous low of 19% in 1994, which doesn’t seem to correspond to anything especially bad going on in the US, so I don’t know. 20: AskReddit: Medical professionals - have you ever had a patient so lacking in common sense you wondered how they made it so far? Linking this because there’s lots of evidence showing that education (as a proxy for intelligence?) is associated with increased life expectancy, and this thread gives you a visceral appreciation of why that might be. 21: The Fall Of [programming help site] Stack Overflow: Looks like a weak downward trend since 2021 I can’t explain, plus a strong downward trend since 11/2022 which must be from ChatGPT. In case you were wondering how AI was affecting programming! (update: probably false, see here, though see also here for evidence of smaller but real decline) 22: This month in culture war topics: London’s Pride parade featured a convicted kidnapper/torturer/rapist/sadist as a speaker, who advocated that anti-trans people should be “punch[ed] in the f**king face” ; the organizers say they stand by her.
Inline links: favorite AI governance research this year, Chichijima incident, claims results, painkillers were just generally in short supply in India during her era, here, record, here, https://substackcdn.com/image/fetch/$s_!6brT!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F172f7be6-1e03-4919-9cc9-b04335223f35_1280x1030.jpeg, yes, this argument for no, agrees no, argues yes, argument for no, Stuart Ritchie, Anthropic, an Anthropic article, the same argument I would, More nails in the coffin of growth mindset, Previous work, Chetty, Deming, and Friedman, has a Substack here where he explains the study in more depth, https://substackcdn.com/image/fetch/$s_!VcFl!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F4f08bfe5-ab31-453a-896a-54ef385da7d2_706x900.jpeg, Nate Silver, Erik Hoel, @data_depot, https://substackcdn.com/image/fetch/$s_!S4g-!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Ff18fa4d5-9ba9-4b86-a058-46246bfc8a4f_536x611.png, here, my review of, have you ever had a patient so lacking in common sense you wondered how they made it so far?, The Fall Of [programming help site] Stack Overflow, https://substackcdn.com/image/fetch/$s_!E7XK!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Ff8ba7c05-7dbb-4318-9da2-87b00d738ed7_649x518.png, probably false, see here, here, featured, stand by her
Pause For Thought: The AI Pause Debate
October 05, 2023 · Original source
Zach Stein-Perlman made some good points about the technical factors that made pauses better vs. worse, which I’ve tried to fold into the Surgical Pause section above.
Inline links: made some good points
OpenAI Nonprofit Buyout: Much More Than You Wanted To Know
March 13, 2025 · Original source
Zach Stein-Perlman, who runs AI Lab Watch, argues that Maybe Anthropic’s Long-Term Benefit Trust Is Powerless. He points to a rule that a supermajority (with complicated definition, see here) of stockholders can overrule the LTBT. Anthropic partisans counter that they need some way to deal with the trust losing the plot; many of Anthropic’s shareholders are also people with a special interest in AI safety, and it would be hard to get a majority of these people to overrule the LTBT unless it was important.
Inline links: AI Lab Watch, Maybe Anthropic’s Long-Term Benefit Trust Is Powerless, here
Zvi Mowshowitz5 mentions across 5 issues

Zvi Mowshowitz is a recurring person in the Astral Codex Ten archive, appearing 5 times across 5 issues between February 05, 2021 and May 08, 2024. The archive places it in contexts such as ""Zvi Mowshowitz is the first name to come to mind""; "Zvi Mowshowitz , rationalist/blogger"; "54th: Zvi Mowshowitz. Zvi is a former trader and professional Magic player who blogs at Don’t Worry About The Vase". It most often appears alongside Biden, Manifold, Metaculus.

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Zvi Mowshowitz
Mention count
5
Issue count
5
First seen
February 05, 2021
Last seen
May 08, 2024
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WebMD, And The Tragedy Of Legible Expertise
February 05, 2021 · Original source
I can't tell you how many times over the past year all the experts, the CDC, the WHO, the New York Times, et cetera, have said something (or been silent about something in a suggestive way), and then some blogger I trusted said the opposite, and the blogger turned out to be right. I realize this kind of thing is vulnerable to selection bias, but it's been the same couple of bloggers throughout, people who I already trusted and already suspected might be better than the experts in a lot of ways. Zvi Mowshowitz is the first name to come to mind, though there are many others.
Inline links: said the opposite, Zvi Mowshowitz
22
October 18, 2022 · Original source
Zvi Mowshowitz, rationalist/blogger
Inline links: Zvi Mowshowitz
Who Predicted 2022?
January 24, 2023 · Original source
54th: Zvi Mowshowitz. Zvi is a former trader and professional Magic player who blogs at Don’t Worry About The Vase. Since he’s one of the only other bloggers interested in forecasting, I often end up pitted against him in forecasting competitions. I always lose, and this won’t be the year that breaks my streak.
Inline links: Don’t Worry About The Vase
23
October 31, 2023 · Original source
Local parents (including Malcolm and Simone Collins, Zvi Mowshowitz, and Byrne Hobart) discuss parenting and pronatalism (unless I missed it, there was no attempt to connect this to prediction markets, but it was a great talk)
Inline links: discuss parenting and pronatalism
Zvi on California's AI Bill
May 08, 2024 · Original source
But Zvi Mowshowitz (summary article in Asterisk, long FAQ on his blog) has looked at it more closely and found:
Inline links: Zvi Mowshowitz, summary article in
Zaha Hadid4 mentions across 4 issues

Zaha Hadid is a recurring person in the Astral Codex Ten archive, appearing 4 times across 4 issues between April 14, 2021 and September 04, 2023. The archive places it in contexts such as "prohibited them from designing low cost, beautiful Zaha Hadid style structures"; "frank gehry vs frank lloyd wright vs moshe safdie vs zaha hadid"; "The Zaha Hadid residences will break ground soon". It most often appears alongside Germany, Honduras, America.

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Zaha Hadid
Mention count
4
Issue count
4
First seen
April 14, 2021
Last seen
September 04, 2023
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Prospectus On Próspera
April 14, 2021 · Original source
Patrick Schumacher is the Principal Architect of Zaha Hadid, a world-famous architectural firm that designed eg Beijing International Airport and the London Olympics’ Aquatics Center. He’s won some of architecture’s most prestigious prizes, but also faced controversy over views his Wikipedia page describes as “aligned with anarcho-capitalism in favour of complete decentralisation and radical privatisation of all aspects of architecture, planning and development”. He recently lost a court case over ownership of his architecture company, and…wait, haven’t I read this Ayn Rand book before?
Inline links: his Wikipedia page, lost a court case
Trey: “Building codes and rules around aesthetics and setbacks and whatnot prohibited them from designing low cost, beautiful Zaha Hadid style structures prior to now. And without modular construction, it was impossible to get construction costs down to a reasonable number. But they’ve finally managed to pull it off, in coordination with [local startup] Circular Factory.” Drones sold separately. I think. Actually, scratch that, who even knows anymore? Próspera also promises an unprecedented level of customization. The houses are modular enough that you can design yours however you want. I haven’t been able to get access to the real program (called “the Configurator”) yet, but here are some apparent screenshots:
Inline links: https://substackcdn.com/image/fetch/$s_!Bw98!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F943e2b62-b415-4787-9a8c-b95eb63d874a_800x555.png
Highlights From The Comments On Modern Architecture
October 04, 2021 · Original source
i think the most famous and esteemed architecture of the last 50 years is *extremely* diverse. frank gehry vs frank lloyd wright vs moshe safdie vs zaha hadid look like they come from different planets.
21
November 08, 2021 · Original source
Próspera's presentation was mostly a rehash of information everyone here knows with a handful of new tidbits. The Apolo Group apartment buildings (totaling 250 units) did break ground recently (they're still using the La Ceiba, Honduras building code, but not having to deal with zoning and other permitting was a huge draw). The Zaha Hadid residences will break ground "soon". PES has about 30 people working and living in Próspera and there's apparently upcoming announcements relating to increasing this massively. They've got plans to attract medical and finance (specifically crypto/distributed finance) industries. There's currently a bank going through the "propose your own regulatory code" process.
Inline links: did break ground recently
23: California Dreamin'
September 04, 2023 · Original source
Building progress: last I heard Duna Residences were supposed to be ready Q2 2023, but a recent video shows them still under construction. In March, Prospera said they would be “breaking ground on Pristine Heights” soon, but there have been no further updates. And a representative says they still plan to start Beyabu (futuristic-looking Zaha Hadid buildings) “the second half of this year”. Duna Residences (website) Pristine Heights (website) Beyabu (website)
Inline links: Duna Residences, still under construction, Pristine Heights, https://substackcdn.com/image/fetch/$s_!hJoX!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F2931de48-b485-41f8-b8b8-ef282086c09d_1730x749.png, https://substackcdn.com/image/fetch/$s_!aCHj!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F8c9aba63-c8e6-4c58-855c-7f6ad03327b2_1557x1009.png, website, https://substackcdn.com/image/fetch/$s_!9C33!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F07945f63-c49a-4671-b35e-5b0092fd2c92_960x547.jpeg, website
Zeus4 mentions across 4 issues

Zeus is a recurring person in the Astral Codex Ten archive, appearing 4 times across 4 issues between June 07, 2022 and November 12, 2024. The archive places it in contexts such as "Like a character in a Greek tragedy saying that not even Zeus can harm him"; "Zeus’ forehead"; "the statue in Babylon, which was called the statue of Zeus". It most often appears alongside Athens, Alexandria, Athena.

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Zeus
Mention count
4
Issue count
4
First seen
June 07, 2022
Last seen
November 12, 2024
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My Bet: AI Size Solves Flubs
June 07, 2022 · Original source
And when I do this, “Gary Marcus post talking about how some AI isn’t real intelligence because it can’t do X, Y, and Z” feels like a concerning sign. Like a character in a Greek tragedy saying that not even Zeus can harm him. Or a billionaire investor saying we’ve entered a new paradigm where recessions are impossible.
Your Book Review: Njal’s Saga
June 16, 2023 · Original source
And cites as evidence for this the birth of Athena herself, who was born parthenogenetically from Zeus’ forehead. This is dubious even within the context of Greek mythology - the modern synthesis says that Zeus had previously swallowed his pregnant consort Metis - but presumably Aeschylus was working from different sources. In any case, Athena herself endorses this description, so it’s Word of God(dess) for this play.
Book Review: The Alexander Romance
September 19, 2023 · Original source
When Alexander [said his last goodbye to his horse Bucephalus], the whole army howled, making a tremendous noise. The treacherous slave who had prepared the poison and who had plotted against their lives thought that Alexander was dead, and came running to see. When Bucephalus saw him, he cast off his morose and dejected look, and, just as if he were a rational, even a clever man - I suppose it was done through Providence above - he avenged his master. He ran into the midst of the crowd, seized the slave in his teeth, and dragged him to Alexander; he shook him violently and gave a loud whinny to show that he was going to have his revenge. Then he took a great leap into the air, dragging the treacherous and deceitful slave with him, and smashed him against the ground. The slave was torn apart; bits of him flew all over everyone like snow falling off a roof in the wind. The horse got up, neighed a little, and then fell down before Alexander and breathed his last. Alexander smiled at him. Then the air was filled with mist, and a great star was seen descending from the sky, accompanied by an eagle; and the statue in Babylon, which was called the statue of Zeus, trembled. When the star ascended again to the sky, accompanied by the eagle, and had disappeared, Alexander fell into his eternal sleep.
Book Review: The Rise Of Christianity
November 12, 2024 · Original source
Search for meaning. In some cities, 50% of the population died. The survivors must have been shell-shocked and looking for some sort of meaning behind it all. Paganism had nothing for them - “sorry, we don’t do that kind of thing, would you like to hear another story about Zeus raping a woman and turning her into an animal?” Christians, who had wise words about how God tests the faithful and sometimes brings people to Heaven before their time, must have been a vastly superior alternative.
Zuck3 mentions across 3 issues

Zuck is a recurring person in the Astral Codex Ten archive, appearing 3 times across 3 issues between September 22, 2022 and July 21, 2025. The archive places it in contexts such as "unlike Zuck, they were not able to keep their thing going strong"; "D’Angelo, he used to work for Zuck"; "I heard Zuck offered him fifty billion to work at Meta AI". It most often appears alongside Amazon, Elon Musk, Mark Zuckerberg.

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Zuck
Mention count
3
Issue count
3
First seen
September 22, 2022
Last seen
July 21, 2025
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Highlights From The Comments On Billionaire Replaceability
September 22, 2022 · Original source
I’m still not sure about this line of thought. How is this situation? Do we think Mark Zuckerberg wouldn’t have founded Facebook, or Bill Gates Microsoft, if he could only get $1 billion? Can people really tell the difference between $10 billion and $100 billion? Has Jeff Bezos even spent $10 billion?
I think this is actually a significant problem w/ Scott's last argument - the founders of Friendster and Myspace aren't infamously super-rich, because unlike Zuck, they were not able to keep their thing going strong, in the face of competition, over a long period of time. Getting in first is a huge advantage - but then competition comes in and challenges you. If you don't rise to that challenge, you may walk away with some I-did-it-first money, but the competition will wind up getting the big pot. If you consistently whoop the competition, it's either because you're providing better value, or because you're shrewder at business (this latter part is something the left can perhaps legit complain about, but it's a hard thing to correct accurately). To the extent you're providing better value than all the other competitors who come along over the years, you should reap proportionate rewards. So it is w/ amazon - no one else has 2 day shipping afaik. This accords w/ a general statement about profit margins and competition - low competition should naturally lead to high profit margins, because you're apparently doing something so hard or risky that hardly anyone else can manage to pull it off (this argument falls apart completely when you have low competition because you're exploiting regulation, e.g. IP laws, or when you have a true monopoly).
Son Of Bride Of Bay Area House Party
December 12, 2023 · Original source
“Are you talking about Sam Altman?” asked a man who you didn’t even realize was listening to the conversation. “I’ve been trying to figure the whole situation out. I understand that Toner was part of the deep state conspiracy and McCauley was part of the effective altruist conspiracy. And D’Angelo, he used to work for Zuck, so he must have been part of the Meta conspiracy - Meta as in Facebook, not meta-conspiracy in the sense of a conspiracy controlling all the others. There was a meta-conspiracy controlling all the others, but that was . . . “
Press Any Key For Bay Area House Party
July 21, 2025 · Original source
"Hey man," says Mark Zuckerberg, grabbing your wrist. "You wanna come build superintelligence at Meta? I'll give you five million, all cash."
Mark Zuckerberg, heavily bruised and covered in glitter, stands in front of the smoking ruins of your wheelchair and laughs maniacally. He is holding a small silver box he has extracted from one of the fragments. “I got it!” he shouts. “I got the last GPU in San Francisco!”
“Let me guess,” you say, finding the host. “You got Zucked.”
Zach2 mentions across 2 issues

Zach is a recurring person in the Astral Codex Ten archive, appearing 2 times across 2 issues between June 13, 2021 and May 24, 2022. The archive places it in contexts such as "which Zach describes as 'so smooth, so much less "buzzy" than with caffeine'"; "Not only does he tell us his children’s names - Christian, Zach, Elijah, Niko, and Cameron - but each of them has made an impeccably-produced campaign video". It most often appears alongside California, #Abolitionist, #AntiNazi.

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Zach
Mention count
2
Issue count
2
First seen
June 13, 2021
Last seen
May 24, 2022
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Source context
Open Thread 176
June 13, 2021 · Original source
4: Comments of the week were on Drug Users Use A Lot Of Drugs, where many people pointed out that cocaine works this way too. Coca tea is an over-the-counter stimulant in Peru, which Zach describes as "so smooth, so much less 'buzzy' than with caffeine, that it seems criminal it's not legal in the US", and Harry Deuchar calculates that the average coca tea drinker in Peru might get about 4 mg of cocaine, whereas the average addict gets about 900 mg a day. This helps put a lot of things in perspective for me, like how Coca-Cola used to have cocaine in it - probably this was completely reasonable and a fine choice! (this last sentence is so not medical advice)
Inline links: Zach describes, Harry Deuchar
California Gubernatorial Candidates From Z to Z
May 24, 2022 · Original source
Not only does he tell us his children’s names - Christian, Zach, Elijah, Niko, and Cameron - but each of them has made an impeccably-produced campaign video talking about what their father means to them.
Zach Goldberg2 mentions across 2 issues

Zach Goldberg is a recurring person in the Astral Codex Ten archive, appearing 2 times across 2 issues between June 14, 2021 and August 09, 2023. The archive places it in contexts such as "source: Zach Goldberg"; "H/T Zach Goldberg on X". It most often appears alongside Britain, @data_depot, @StefanFSchubert.

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Zach Goldberg
Mention count
2
Issue count
2
First seen
June 14, 2021
Last seen
August 09, 2023
Outbound links
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Source context
Contra Smith On Jewish Selective Immigration
June 14, 2021 · Original source
(source: Zach Goldberg)
Inline links: Zach Goldberg
Links For August 2023
August 09, 2023 · Original source
5: Debate between commenter and friend of the blog David Friedman, and Austrian economist Gene Epstein, on whether libertarianism’s standard pitch should center on the non-aggression principle vs. practical benefits. I’m not very interested in the propaganda angle, but they use it as a jumping-off point to discuss the broader battle for the soul of libertarianism. 6: The Murchison Murders were a series of murders which began when a mystery writer asked his friends to help him come up with the perfect body disposal method. One friend came up with a method so good that another friend, who overheard it, couldn’t resist putting it into action. He got away with two killings, got cocky, didn’t perform the full method on the third, and was caught by police. 7: Claim: in the 1980s, the life satisfaction / depression rates of liberal and conservative youth were about equal; over the past few years, young liberals have increasingly gotten worse while conservatives stay about the same. H/T Zach Goldberg on X: 8: Zach Stein-Perlman’s favorite AI governance research this year. 9: The Chichijima incident was notable as a time when George H. W. Bush almost got eaten by cannibals. During WWII, nine American pilots were shot down over an island commanded by a crazy Japanese officer who ate his enemies' livers. Eight were captured and killed (and four of those were eaten), and Bush alone fled and survived. 10: El Salvador’s murder crackdown claims results of 90% decrease in homicides, 44% decrease in emigration to US, and 90% approval rating for president Nayyib Bukele (h/t Richard Hanania). 11: In an earlier set of comments, I ignorantly repeated a claim that Mother Teresa denied her patients painkillers because she thought suffering brought people closer to God. A commenter corrected me: painkillers were just generally in short supply in India during her era (more discussion here). 12: The record for longest time a plane has spent in the air without landing is 64 days, achieved by a Cessna in 1959. You can read the full story here, but the basic setup looked like this: 13: Fact check: was Elvis Jewish? Snopes says yes, but I’m more convinced by this argument for no. [update: commenter TheGenealogian agrees no] 14: Is GPT-4 getting worse? This isn’t absurd; some people claim OpenAI has simplified the model to cut costs (though OpenAI denies this). Matei Zaharia argues yes, but I’m more convinced by the AI Snake Oil blog’s argument for no (h/t Stuart Ritchie). 15: Vox has a good piece about AI company Anthropic. I would quibble that they’re not the only safety-focused or EA-affiliated org, and we have yet to see how truly safety-focused or altruistic any AI company can be while continuing to be an AI company. But granting that it’s all a matter of degree, I agree the degree seems pretty high for them. And NYT also has an Anthropic article. 16: Eliezer bets $150,000 to $1,000 against UFOs being aliens, and gives the same argument I would - it’s unlikely that any civilization advanced enough to travel through space would still be primitive enough to use macroscopic, biologically-piloted craft that sometimes crash. 17: More nails in the coffin of growth mindset. “When examining the highest-quality evidence (6 studies, N = 13,571), the effect was nonsignificant: d = 0.02, 95% CI = [−0.06, 0.10]. We conclude that apparent effects of growth mindset interventions on academic achievement are likely attributable to inadequate study design, reporting flaws, and bias.” I think the older, very-high-effect-size studies were clearly terrible, but I’d still like to look further into the newer, small-but-significant-effect-size-that-makes-a-difference-across-large-groups studies and how they went wrong. 18: Previous work showed that after adjusting for selection bias, “what college you go to doesn’t matter” for average earnings. I was always skeptical of this - are all those rich people sending their kids to Ivies for no reason? Now Chetty, Deming, and Friedman find that: Attending an Ivy-Plus college instead of the average highly selective public flagship institution increases students’ chances of reaching the top 1% of the earnings distribution by 60%, nearly doubles their chances of attending an elite graduate school, and triples their chances of working at a prestigious firm. Ivy-Plus colleges have much smaller causal effects on average earnings, reconciling our findings with prior work. One of the authors, David Deming, has a Substack here where he explains the study in more depth. Like everyone else, this study also finds that rich people are using “holistic admissions” and the de-emphasis of standardized testing to gain an advantage: H/T Nate Silver, who writes: “Not sure how you can look at this data, ostensibly be interested in either meritocracy or equality, and want to move away from standardized tests. It's the subjective measures that are most slanted in favor of the rich kids.” Cf. Erik Hoel. 19: From @data_depot: “In 2002, 48% of Americans said "the govt is run by a few big interests looking out for themselves." 52% said "it is run for the benefit of all people." In 2020, 84% said the govt is run by a few big interests. Only 16% said it is run for the benefit of all people.” Source seems to be here, which reveals 2002 was a local peak in trust in government; maybe because of post-9/11 unity, but even 2000 was 34%, much better than our current 16%. My first instinct is to attribute this to a rise in vulgar Marxism, in the sense of everyone (even conservatives) now being trained to think in terms of an elite class screwing over everyone else (cf my review of Manufacturing Consent). But there was a previous low of 19% in 1994, which doesn’t seem to correspond to anything especially bad going on in the US, so I don’t know. 20: AskReddit: Medical professionals - have you ever had a patient so lacking in common sense you wondered how they made it so far? Linking this because there’s lots of evidence showing that education (as a proxy for intelligence?) is associated with increased life expectancy, and this thread gives you a visceral appreciation of why that might be. 21: The Fall Of [programming help site] Stack Overflow: Looks like a weak downward trend since 2021 I can’t explain, plus a strong downward trend since 11/2022 which must be from ChatGPT. In case you were wondering how AI was affecting programming! (update: probably false, see here, though see also here for evidence of smaller but real decline) 22: This month in culture war topics: London’s Pride parade featured a convicted kidnapper/torturer/rapist/sadist as a speaker, who advocated that anti-trans people should be “punch[ed] in the f**king face” ; the organizers say they stand by her.
Inline links: whether libertarianism’s standard pitch should center on the non-aggression principle vs. practical benefits, The Murchison Murders, H/T Zach Goldberg on X, https://substackcdn.com/image/fetch/$s_!WHwj!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fbb633661-9451-4f48-8830-0352a69ae594_2376x1358.jpeg, favorite AI governance research this year, Chichijima incident, claims results, painkillers were just generally in short supply in India during her era, here, record, here, https://substackcdn.com/image/fetch/$s_!6brT!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F172f7be6-1e03-4919-9cc9-b04335223f35_1280x1030.jpeg, yes, this argument for no, agrees no, argues yes, argument for no, Stuart Ritchie, Anthropic, an Anthropic article, the same argument I would, More nails in the coffin of growth mindset, Previous work, Chetty, Deming, and Friedman, has a Substack here where he explains the study in more depth, https://substackcdn.com/image/fetch/$s_!VcFl!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F4f08bfe5-ab31-453a-896a-54ef385da7d2_706x900.jpeg, Nate Silver, Erik Hoel, @data_depot, https://substackcdn.com/image/fetch/$s_!S4g-!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Ff18fa4d5-9ba9-4b86-a058-46246bfc8a4f_536x611.png, here, my review of, have you ever had a patient so lacking in common sense you wondered how they made it so far?, The Fall Of [programming help site] Stack Overflow, https://substackcdn.com/image/fetch/$s_!E7XK!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Ff8ba7c05-7dbb-4318-9da2-87b00d738ed7_649x518.png, probably false, see here, here, featured, stand by her
Zelenskyy2 mentions across 2 issues

Zelenskyy is a recurring person in the Astral Codex Ten archive, appearing 2 times across 2 issues between March 01, 2022 and January 24, 2023. The archive places it in contexts such as "Zelenskyy was saying everything would be okay"; "most accurate source of forecasts on a Ukraine cease-fire - that would be... Zelenskyy". It most often appears alongside ACX, Less Wrong, Manifold.

Article page
Zelenskyy
Mention count
2
Issue count
2
First seen
March 01, 2022
Last seen
January 24, 2023
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Ukraine Warcasting
March 01, 2022 · Original source
Current conventional wisdom is that the invasion was a miscalculation on Putin’s part, after he surrounded himself with so many yes-men that he lost touch with reality. But Ukraine miscalculated too; until almost the day of the invasion, Zelenskyy was saying everything would be okay. And if there’s a nuclear exchange, it will be because of miscalculation - I don’t know what the miscalculation will be, just that nobody goes into a nuclear exhange because they want to. Preserving people’s access to reality and helping them avoid miscalculations are peacekeeping measures, sometimes very important ones.
Inline links: are
This is the most-predicted relevant question on Metaculus right now. The first day of the war, the market predicted as high as 90%; as people realized the strength of Ukrainian resistance, it fell to 80. Mid-Saturday there was a sudden drop from 78% to 72%, after some combination of a defiant Zelenskyy speech and a report that Russian paratroopers had been repelled. Since then it’s barely budged.
— Will Zelensky still be President of Ukraine on 4/22/22? 42% chance Polymarket seems hesitant to go into actual war predictions, but this market at least acts as a proxy for whether there will be a Ukraine on 4/22/22 - though with a side of “will Zelensky be killed or captured?”. “Yes” dropped as low as 12% during the early parts of the invasion, but is doing a little better now.
Inline links: https://polymarket.com/market/will-volodymyr-zelenskyy-be-ukraines-president-on-april-22-2022
Who Predicted 2022?
January 24, 2023 · Original source
None of these aggregation methods are the most accurate source of forecasts on a Ukraine cease-fire - that would be Putin and Zelenskyy, who could have secret plans they haven’t announced. These methods might not even be the most accurate public source - maybe that’s someone with an International Relations PhD who’s studied the region their whole life.
Zelinskyy2 mentions across 2 issues

Zelinskyy is a recurring person in the Astral Codex Ten archive, appearing 2 times across 2 issues between March 14, 2022 and March 21, 2022. The archive places it in contexts such as "Will Zelinskyy no longer be President of Ukraine on 4/22?". It most often appears alongside ACX Grants, Kiev, Metaculus.

Article page
Zelinskyy
Mention count
2
Issue count
2
First seen
March 14, 2022
Last seen
March 21, 2022
Outbound links
Issue trail
  • 22 March 14, 2022
  • 22 March 21, 2022
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Source context
22
March 14, 2022 · Original source
Will Zelinskyy no longer be President of Ukraine on 4/22?: 63% —→20%
Inline links: Will Zelinskyy no longer be President of Ukraine on 4/22
22
March 21, 2022 · Original source
Will Zelinskyy no longer be President of Ukraine on 4/22?: 20% —→15%
Inline links: Will Zelinskyy no longer be President of Ukraine on 4/22
Zichan2 mentions across 2 issues

Zichan is a recurring person in the Astral Codex Ten archive, appearing 2 times across 2 issues between September 01, 2023 and September 15, 2023. The archive places it in contexts such as "Zichan would not permit it, saying"; "a minister of a neighboring state wrote a lengthy protest to his friend Zichan (the dragon-ignorer), then the chief minister of Zheng"; ""Zichan wrote back:"". It most often appears alongside ACX, Zuozhuan, 536 BC.

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Zichan
Mention count
2
Issue count
2
First seen
September 01, 2023
Last seen
September 15, 2023
Outbound links
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Source context
Your Book Review: Zuozhuan
September 01, 2023 · Original source
The Zuozhuan can’t provide satisfying answers. But it can provide a sense of perspective, and recognition. I can conclude with one further anecdote from the Zuozhuan, for the commentators to the commentary on the commentary to weigh as they see fit. In 536 BC, toward the end of the Spring and Autumn period, the state of Zheng cast a penal code in bronze. By the standards of the time, this was absolutely shocking, an upending of the existing order—to not only have a written law code, but to prepare it for public display so everyone could read it. A minister of a neighboring state wrote a lengthy protest to his friend Zichan (the dragon-ignorer), then the chief minister of Zheng:
There was a great flood in Zheng, and dragons fought in the Wei pool outside the southern gate of the capital. The inhabitants of the capital asked permission to perform an expiatory sacrifice to them. Zichan would not permit it, saying, “When we fight, dragons take no notice of us, so why should we for our part take notice when dragons fight? You might exorcise them, but then the water is their home. We have nothing to ask of dragons, and dragons likewise have nothing to ask of us.” They therefore gave up the idea.
“When there was disorder in the Xia government, they created the ‘Punishments of Yu.’ When there was disorder in the Shang government, they created the ‘Punishments of Tang.’ When there was disorder in the Zhou government, they composed the ‘Nine Punishments.’ These three penal codes in each case arose in the dynasty’s waning era. Now as chief minister in the domain of Zheng you, Zichan, have created fields and ditches, established an administration that is widely reviled, fixed the three statutes, and cast the penal code. Will it not be difficult to calm the people by such means? As it says in the Odes,
Book Review Contest 2023 Winners
September 15, 2023 · Original source
Some extra praise: Man's Search For Meaning placed 4th; I thought it was a good review of an important book by someone who's clearly thought about these issues a lot. I loved Public Citizen; I had a vague sense that a lot of government happens by lawsuit now and it hadn't always been this way, but I wouldn't have even known where to start in figuring out why and how this happened, and I had always thought of Nader as "that car guy who everyone mysteriously thought was important who then lost the 2000 election", so I'm glad to get more clarity there. Zuozhuan was oddly haunting and I will remember the part about Zichan and the law code for a long time. Don't Sleep, There Are Snakes was a discussion of the Piraha (the weird tribe that doesn't seem to have supposedly universal features of language and culture) which gave a great sense of how it might feel to be a primitive rainforest tribe.
Zizek2 mentions across 2 issues

Zizek is a recurring person in the Astral Codex Ten archive, appearing 2 times across 2 issues between August 30, 2023 and October 17, 2024. The archive places it in contexts such as "To put it in an even more Zizekian fashion, I have to quote Zizek himself (in “The Plague of Fantasies,” 2009)"; "If you made Zizek write fiction". It most often appears alongside 2020 election, 23andme, ACX.

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Zizek
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2
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2
First seen
August 30, 2023
Last seen
October 17, 2024
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Highlights From The Comments On Fetishes
August 30, 2023 · Original source
I find it remarkable that, even though he’s somebody who has written somewhat disparagingly of Slavoj Zizek in the past, the study of fetishes has led Scott to arrive at an understanding of sexuality not unlike Zizek’s. The way Zizek sees it, sexuality has a universal surplus, a capacity to overflow the entire field of human experience so that everything, from eating to excretion, from beating up our fellow man (or getting beaten up by him) to the exercise of power, can acquire a sexual connotation. And this is not a sign of its preponderance, but one of a certain structural faultiness: sexuality strives outward and overflows the adjoining domains precisely because it cannot find satisfaction in itself, because it never attains its goal or never-ending reproduction and because – as Alexander argues – sexuality is continuously thwarted by evolution – condoms, porn, etc – so, in Deleuzian terms, “perversion enters the stage as an inherent reversal of this ‘normal’ relationship between the asexual, literal sense and the sexual co-sense.” In perversion, even light perversion such as the one expressed by foot fetishes, sexuality becomes one desexualized object among others. To put it in an even more Zizekian fashion, I have to quote Zizek himself (in “The Plague of Fantasies,” 2009): “This link between sexualization and failure is of the same nature as the link between matter and space curvature in Einstein: matter is not a positive substance whose density curves space, it is tied to the curvature of space. By analogy, one should also 'desubstantialize' sexuality: sexuality is not a kind of traumatic substantial Thing, which the subject cannot attain directly; it is nothing but the formal structure of failure which, in principle, can 'contaminate' any activity. So, again, when we are engaged in an activity which fails to attain its goal directly, and gets caught in a repetitive vicious cycle, this activity is automatically sexualized - a rather vulgar everyday example: if, instead of simply shaking my friend's hand, I were to squeeze his palm repeatedly for no apparent reason, this repetitive gesture would undoubtedly be experienced by him or her as sexualized in an obscene way.”
Book Review: Deep Utopia
October 17, 2024 · Original source
If you made Zizek write fiction, you would get Deep Utopia. The book takes the form of a story. The story is: some young people go to a lecture series by Nick Bostrom. At the lecture, Bostrom says [commence 468 pages of Bostrom describing his theory of purpose in utopia]. Then the young people go to a party, then go home. The end.
Zuckerberg2 mentions across 2 issues

Zuckerberg is a recurring person in the Astral Codex Ten archive, appearing 2 times across 2 issues between April 05, 2023 and October 21, 2025. The archive places it in contexts such as "I think any of Xi, Biden, or Zuckerberg meet this low bar"; "maybe everyone else in tech hates Zuckerberg too much to work with him". It most often appears alongside Meta, A16Z, AI.

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Zuckerberg
Mention count
2
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2
First seen
April 05, 2023
Last seen
October 21, 2025
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Most Technologies Aren't Races
April 05, 2023 · Original source
Even in the unlikely scenario where AI causes a singularity and remains aligned, I have trouble worrying too much about races. The whole point of a singularity is that it’s hard to imagine what happens on the other side of it. I care a lot how much relative power Xi Jinping, Mark Zuckerberg, and Joe Biden have today, but I don’t know how much I care about them after a singularity.
“Wouldn’t Mark Zuckerberg perpetuate structural racism?” You will be able to change your race, age, gender, species, and state of matter at will. Nobody will even remember what race you were. If for some reason the glowing clouds of plasma that used to be black people have smaller customized personal utopian megastructures than the glowing clouds of plasma that used to be white people, you can ask the brain the size of Jupiter how to solve it, and it will tell you (I bet it involves using slightly different euphemisms for things, that’s always been the answer so far).
And yeah, that “they’re not actively a sadist” clause is doing a lot of work. I want whoever rules the post-singularity future to have enough decency to avoid ruining it, and to take the Jupiter-sized brain’s advice when it has some. I think any of Xi, Biden, or Zuckerberg meet this low bar. There are some ideologues and terrible people who don’t, but they seem far away from the cutting edge of AI.
Tech PACs Are Closing In On The Almonds
October 21, 2025 · Original source
Give me your degens, your risk-seeking. Your huddled masses, yearning to bet free. IV. …and we’ll be exploring it a whole lot more, very soon. Last month, the AI industry announced a new SuperPAC called “Leading The Future” (a dumb name, but, in their defense, “AIPAC” was already taken). They start with $200 million in seed funding, led by a $50 million donation by Andreessen Horowitz, and another $50 million from OpenAI co-founder Greg Brockman. (Why Brockman and not Altman, or OpenAI as a corporation? Because most people don’t know who Brockman is, so this keeps OpenAI’s hands clean. I imagine Altman going into a meeting, pointing at Brockman, and saying “I’m famous, you’re not, please cough up $50 million of your own money for the cause.”) On the same day, Meta announced their own SuperPAC, Mobilizing Economic Transformation Across (META) California. Why two PACs? Opinions differ; one person told me that it lets the general PAC avoid the negative associations that Facebook has gathered over the years, but the Verge thinks that maybe everyone else in tech hates Zuckerberg too much to work with him. Meta has committed to spending “tens of millions”. Most likely, the new PAC will use the playbook pioneered by crypto: destroy any candidate who dares support regulations on AI, by funding attack ads that don’t mention AI in any way and, at best, briefly mention the name “Leading The Future”. Just the Andreessen/Brockman SuperPAC, without any help from Meta, is already twice as rich as AIPAC. Their existence sends a clear message: we are going to crush any politician who tries to regulate AI. V. …unless someone stops them. Leading The Future still only has 2% as much money as the almond industry. The tiny scale of US political spending is dangerous insofar as it means that one or two billionaires willing to go all-in can distort the national landscape. But it also makes it possible to oppose them. Certainly if you can get one or two billionaires of your own - but it might even be within the range of a committed group of ordinary people. Not waiters and bartenders, maybe. But if safe AI supporters were as committed as Israel supporters, they could probably make something happen. For a long time, the AI safety movement has underperformed politically. Effective altruism includes thousands of well-off people committed to spending 10% of their income on improving the world. If a thousand of them gave $7K each to political candidates, that would be $7 million of campaign-finance-compliant hard money - about as much as anyone can gather for anything. Hard money buys more influence per dollar than soft money, so this could be a big deal. All you’d need is the right people to coordinate it. So far, this has been slow going. Partly it’s because in the early 2020s, people affiliated with FTX took point on this effort; when FTX imploded, it not only took its incipient political infrastructure with it, but poisoned the well for future efforts. And partly it’s because EAs overlearned the lesson of the early 2010s, when we spoke out against AI capabilities efforts so “effectively” that a bunch of people thought “wow, AI capabilities companies must be a really big deal, maybe I should found one!”; the resulting institutional scar tissue biased us towards staying quiet about our concerns. Still, I wouldn’t be writing this if the consultants and activists weren’t gearing up for a bigger fight. They asked me to include some action items for readers who want to participate: Email aisafetypolitics@gmail.com to connect to the people organizing this effort and talk with them about what you can do, including potential future donation opportunities.
Inline links: announced a new SuperPAC, Mobilizing Economic Transformation Across, the Verge thinks
Zutano2 mentions across 2 issues

Zutano is a recurring person in the Astral Codex Ten archive, appearing 2 times across 2 issues between November 23, 2021 and March 16, 2022. The archive places it in contexts such as "Zutano adds : To expand on this more: the clinical trials only show that *that one particular batch* was safe and efficacious"; "— Zutano (whose name makes them sound like another novel drug in this class!) debunks my urban legend". It most often appears alongside Scott, 5α-reductase inhibitor, A Mindful Monkey.

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Zutano
Mention count
2
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2
First seen
November 23, 2021
Last seen
March 16, 2022
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Highlights From The Comments On The FDA And Paxlovid
November 23, 2021 · Original source
Zutano adds:
Inline links: adds
Highlights From The Comments On Zulresso
March 16, 2022 · Original source
— Zutano (whose name makes them sound like another novel drug in this class!) debunks my urban legend that the -pam at the end of benzo names (eg “diazepam”) stands for positive allosteric modulator:
Inline links: Zutano
Z. He1 mentions across 1 issues

Z. He is a recurring person in the Astral Codex Ten archive, appearing 1 times across 1 issues between August 14, 2025 and August 14, 2025. The archive places it in contexts such as "Z. He et al. , “Amyloid-β plaques enhance Alzheimer’s brain tau-seeded pathologies by facilitating neuritic plaque tau aggregation,” Nature Medicine". It most often appears alongside A. Bejanin, A. de Calignon, A. Elobeid.

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Z. He
Mention count
1
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1
First seen
August 14, 2025
Last seen
August 14, 2025
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In Defense Of The Amyloid Hypothesis
August 14, 2025 · Original source
[54] Z. He et al., “Amyloid-β plaques enhance Alzheimer’s brain tau-seeded pathologies by facilitating neuritic plaque tau aggregation,” Nature Medicine, vol. 24, no. 1, pp. 29–38, Jan. 2018, doi: 10.1038/nm.4443.
Inline links: 10.1038/nm.4443
Z. Jaunmuktane1 mentions across 1 issues

Z. Jaunmuktane is a recurring person in the Astral Codex Ten archive, appearing 1 times across 1 issues between August 14, 2025 and August 14, 2025. The archive places it in contexts such as "[21] Z. Jaunmuktane et al., “Evidence for human transmission of amyloid-β pathology and cerebral amyloid angiopathy,”". It most often appears alongside A. Bejanin, A. de Calignon, A. Elobeid.

Reference entry
Z. Jaunmuktane
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1
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1
First seen
August 14, 2025
Last seen
August 14, 2025
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In Defense Of The Amyloid Hypothesis
August 14, 2025 · Original source
[21] Z. Jaunmuktane et al., “Evidence for human transmission of amyloid-β pathology and cerebral amyloid angiopathy,” Nature, vol. 525, no. 7568, pp. 247–250, Sep. 2015, doi: 10.1038/nature15369.
Inline links: 10.1038/nature15369
Zach Goldbe1 mentions across 1 issues

Zach Goldbe is a recurring person in the Astral Codex Ten archive, appearing 1 times across 1 issues between August 09, 2023 and August 09, 2023. The archive places it in contexts such as "H/T Zach Goldbe". It most often appears alongside @data_depot, @StefanFSchubert, AI Snake Oil blog.

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Zach Goldbe
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1
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1
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August 09, 2023
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August 09, 2023
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Links For August 2023
August 09, 2023 · Original source
5: Debate between commenter and friend of the blog David Friedman, and Austrian economist Gene Epstein, on whether libertarianism’s standard pitch should center on the non-aggression principle vs. practical benefits. I’m not very interested in the propaganda angle, but they use it as a jumping-off point to discuss the broader battle for the soul of libertarianism. 6: The Murchison Murders were a series of murders which began when a mystery writer asked his friends to help him come up with the perfect body disposal method. One friend came up with a method so good that another friend, who overheard it, couldn’t resist putting it into action. He got away with two killings, got cocky, didn’t perform the full method on the third, and was caught by police. 7: Claim: in the 1980s, the life satisfaction / depression rates of liberal and conservative youth were about equal; over the past few years, young liberals have increasingly gotten worse while conservatives stay about the same. H/T Zach Goldberg on X: 8: Zach Stein-Perlman’s favorite AI governance research this year. 9: The Chichijima incident was notable as a time when George H. W. Bush almost got eaten by cannibals. During WWII, nine American pilots were shot down over an island commanded by a crazy Japanese officer who ate his enemies' livers. Eight were captured and killed (and four of those were eaten), and Bush alone fled and survived. 10: El Salvador’s murder crackdown claims results of 90% decrease in homicides, 44% decrease in emigration to US, and 90% approval rating for president Nayyib Bukele (h/t Richard Hanania). 11: In an earlier set of comments, I ignorantly repeated a claim that Mother Teresa denied her patients painkillers because she thought suffering brought people closer to God. A commenter corrected me: painkillers were just generally in short supply in India during her era (more discussion here). 12: The record for longest time a plane has spent in the air without landing is 64 days, achieved by a Cessna in 1959. You can read the full story here, but the basic setup looked like this: 13: Fact check: was Elvis Jewish? Snopes says yes, but I’m more convinced by this argument for no. [update: commenter TheGenealogian agrees no] 14: Is GPT-4 getting worse? This isn’t absurd; some people claim OpenAI has simplified the model to cut costs (though OpenAI denies this). Matei Zaharia argues yes, but I’m more convinced by the AI Snake Oil blog’s argument for no (h/t Stuart Ritchie). 15: Vox has a good piece about AI company Anthropic. I would quibble that they’re not the only safety-focused or EA-affiliated org, and we have yet to see how truly safety-focused or altruistic any AI company can be while continuing to be an AI company. But granting that it’s all a matter of degree, I agree the degree seems pretty high for them. And NYT also has an Anthropic article. 16: Eliezer bets $150,000 to $1,000 against UFOs being aliens, and gives the same argument I would - it’s unlikely that any civilization advanced enough to travel through space would still be primitive enough to use macroscopic, biologically-piloted craft that sometimes crash. 17: More nails in the coffin of growth mindset. “When examining the highest-quality evidence (6 studies, N = 13,571), the effect was nonsignificant: d = 0.02, 95% CI = [−0.06, 0.10]. We conclude that apparent effects of growth mindset interventions on academic achievement are likely attributable to inadequate study design, reporting flaws, and bias.” I think the older, very-high-effect-size studies were clearly terrible, but I’d still like to look further into the newer, small-but-significant-effect-size-that-makes-a-difference-across-large-groups studies and how they went wrong. 18: Previous work showed that after adjusting for selection bias, “what college you go to doesn’t matter” for average earnings. I was always skeptical of this - are all those rich people sending their kids to Ivies for no reason? Now Chetty, Deming, and Friedman find that: Attending an Ivy-Plus college instead of the average highly selective public flagship institution increases students’ chances of reaching the top 1% of the earnings distribution by 60%, nearly doubles their chances of attending an elite graduate school, and triples their chances of working at a prestigious firm. Ivy-Plus colleges have much smaller causal effects on average earnings, reconciling our findings with prior work. One of the authors, David Deming, has a Substack here where he explains the study in more depth. Like everyone else, this study also finds that rich people are using “holistic admissions” and the de-emphasis of standardized testing to gain an advantage: H/T Nate Silver, who writes: “Not sure how you can look at this data, ostensibly be interested in either meritocracy or equality, and want to move away from standardized tests. It's the subjective measures that are most slanted in favor of the rich kids.” Cf. Erik Hoel. 19: From @data_depot: “In 2002, 48% of Americans said "the govt is run by a few big interests looking out for themselves." 52% said "it is run for the benefit of all people." In 2020, 84% said the govt is run by a few big interests. Only 16% said it is run for the benefit of all people.” Source seems to be here, which reveals 2002 was a local peak in trust in government; maybe because of post-9/11 unity, but even 2000 was 34%, much better than our current 16%. My first instinct is to attribute this to a rise in vulgar Marxism, in the sense of everyone (even conservatives) now being trained to think in terms of an elite class screwing over everyone else (cf my review of Manufacturing Consent). But there was a previous low of 19% in 1994, which doesn’t seem to correspond to anything especially bad going on in the US, so I don’t know. 20: AskReddit: Medical professionals - have you ever had a patient so lacking in common sense you wondered how they made it so far? Linking this because there’s lots of evidence showing that education (as a proxy for intelligence?) is associated with increased life expectancy, and this thread gives you a visceral appreciation of why that might be. 21: The Fall Of [programming help site] Stack Overflow: Looks like a weak downward trend since 2021 I can’t explain, plus a strong downward trend since 11/2022 which must be from ChatGPT. In case you were wondering how AI was affecting programming! (update: probably false, see here, though see also here for evidence of smaller but real decline) 22: This month in culture war topics: London’s Pride parade featured a convicted kidnapper/torturer/rapist/sadist as a speaker, who advocated that anti-trans people should be “punch[ed] in the f**king face” ; the organizers say they stand by her.
Inline links: whether libertarianism’s standard pitch should center on the non-aggression principle vs. practical benefits, The Murchison Murders, H/T Zach Goldberg on X, https://substackcdn.com/image/fetch/$s_!WHwj!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fbb633661-9451-4f48-8830-0352a69ae594_2376x1358.jpeg, favorite AI governance research this year, Chichijima incident, claims results, painkillers were just generally in short supply in India during her era, here, record, here, https://substackcdn.com/image/fetch/$s_!6brT!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F172f7be6-1e03-4919-9cc9-b04335223f35_1280x1030.jpeg, yes, this argument for no, agrees no, argues yes, argument for no, Stuart Ritchie, Anthropic, an Anthropic article, the same argument I would, More nails in the coffin of growth mindset, Previous work, Chetty, Deming, and Friedman, has a Substack here where he explains the study in more depth, https://substackcdn.com/image/fetch/$s_!VcFl!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F4f08bfe5-ab31-453a-896a-54ef385da7d2_706x900.jpeg, Nate Silver, Erik Hoel, @data_depot, https://substackcdn.com/image/fetch/$s_!S4g-!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Ff18fa4d5-9ba9-4b86-a058-46246bfc8a4f_536x611.png, here, my review of, have you ever had a patient so lacking in common sense you wondered how they made it so far?, The Fall Of [programming help site] Stack Overflow, https://substackcdn.com/image/fetch/$s_!E7XK!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Ff8ba7c05-7dbb-4318-9da2-87b00d738ed7_649x518.png, probably false, see here, here, featured, stand by her
Zach Groshell1 mentions across 1 issues

Zach Groshell is a recurring person in the Astral Codex Ten archive, appearing 1 times across 1 issues between May 30, 2025 and May 30, 2025. The archive places it in contexts such as "I recommend Zach Groshell’s Just Tell Them: The Power of Explanations and Explicit Teaching". It most often appears alongside 3Blue1Brown, Aella, Alasdair MacIntyre.

Reference entry
Zach Groshell
Mention count
1
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1
First seen
May 30, 2025
Last seen
May 30, 2025
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Bayes For Everyone
May 30, 2025 · Original source
Not that I’m opposed to cog-sci-infused educational traditionalism! For anyone looking for such, I recommend Zach Groshell’s Just Tell Them: The Power of Explanations and Explicit Teaching.
Inline links: http://amazon.com/Just-Tell-Them-Explanations-Explicit/dp/103600368X
Zach Kirkhorn1 mentions across 1 issues

Zach Kirkhorn is a recurring person in the Astral Codex Ten archive, appearing 1 times across 1 issues between September 18, 2023 and September 18, 2023. The archive places it in contexts such as "Zach Kirkhorn ran Tesla". It most often appears alongside 787, adderallposting, ADL.

Reference entry
Zach Kirkhorn
Mention count
1
Issue count
1
First seen
September 18, 2023
Last seen
September 18, 2023
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Highlights From The Comments On Elon Musk
September 18, 2023 · Original source
How would the world look any different to you than it does now if Musk did have depressive phases lasting a month, of the sort he self-medicates with the ketamine he's known to use (not to mention whatever stims or drugs he may be self-medicating with), where he mostly shit-tweeted while folks like Gwynne Shotwell continued to run SpaceX and Zach Kirkhorn ran Tesla (as they always have while doing their best to stop the techno-emperor man-child from follies like rolling out the next Tesla car without a steering wheel because 'FSD is going to work real soon now')?
ZachH1 mentions across 1 issues

ZachH is a recurring person in the Astral Codex Ten archive, appearing 1 times across 1 issues between August 23, 2021 and August 23, 2021. The archive places it in contexts such as "Contact: ZachH, zachary[dot]hamaker[at]gmail[dot]com". It most often appears alongside 1002 N St. NW, Washington DC, 20001, 1022 High St, Madison, 210 Ardmore Avenue.

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ZachH
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1
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1
First seen
August 23, 2021
Last seen
August 23, 2021
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Meetups Everywhere 2021: Times And Places
August 23, 2021 · Original source
GAINESVILLE, FL (RSVP) Contact: ZachH, zachary[dot]hamaker[at]gmail[dot]com Time: 7:30 PM, Tuesday, September 7 Location: 4th Ave Food Park, I’ll be wearing a maroon shirt Coordinates: https://w3w.co/briefer.releases.loyal Notes: Will consider delaying if the COVID situation in FL doesn’t improve
Inline links: RSVP, https://w3w.co/briefer.releases.loyal
Zack Davis1 mentions across 1 issues

Zack Davis is a recurring person in the Astral Codex Ten archive, appearing 1 times across 1 issues between August 21, 2023 and August 21, 2023. The archive places it in contexts such as "debating autogynephilia fetishes with ... Zack Davis". It most often appears alongside 1990s, Aella, Gadget.

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Zack Davis
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1
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1
First seen
August 21, 2023
Last seen
August 21, 2023
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What Can Fetish Research Tell Us About AI?
August 21, 2023 · Original source
Still, I’ve been debating autogynephilia fetishes with Michael Bailey, tailcalled, Zack Davis, and Aella (Bailey and Davis think they’re deeply involved in transgender; tailcalled, Aella and I mostly don’t); I’ve also studied BDSM and lactation fetishes, and Aella has done even more fetish-ology work. In a world that might be on the verge of radical, even unimaginable changes, how do we justify spending time on such an unsavory field?
Inline links: been debating, involved, mostly don’t, BDSM, lactation fetishes, even more fetish-ology work
Zack Goldberg1 mentions across 1 issues

Zack Goldberg is a recurring person in the Astral Codex Ten archive, appearing 1 times across 1 issues between December 28, 2022 and December 28, 2022. The archive places it in contexts such as "Zack Goldberg and Eric Kaufmann surveyed 18-20 year-olds about what they were taught in class". It most often appears alongside 2C-B, 48: Bean, @AliceFromQueens.

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Zack Goldberg
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1
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1
First seen
December 28, 2022
Last seen
December 28, 2022
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Links For December 2022
December 28, 2022 · Original source
19: There is a lot of debate over whether “critical race theory” is being taught in schools. Zack Goldberg and Eric Kaufmann surveyed 18-20 year-olds about what they were “taught in class or heard an adult say in school” and got nationally representative data. I assume that means we can shift to an exactly equally acrimonious debate over whether the specific things the survey found do or don’t qualify as “critical race theory”. In case it helps, here are some of their figures:
Inline links: Zack Goldberg and Eric Kaufmann surveyed 18-20 year-olds
Zack Witten1 mentions across 1 issues

Zack Witten is a recurring person in the Astral Codex Ten archive, appearing 1 times across 1 issues between March 10, 2023 and March 10, 2023. The archive places it in contexts such as "Zack Witten reports playing chess with Bing". It most often appears alongside Alex, Alex Nowratesh, Aphantasia.

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Zack Witten
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1
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1
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March 10, 2023
Last seen
March 10, 2023
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Links For March 2023
March 10, 2023 · Original source
11: A few years ago I wrote about attempts to make GPT-2 play chess; it couldn’t consistently make legal moves, but when it did, its moves seemed better than random although still not great. Zack Witten reports playing chess with Bing (either a late GPT-3 or an early GPT-4) and finds it’s much better - he reports consistently legal play with Elo of about 1100 (around the level of an okay beginner who’s stopped being too embarrassing). Other commenters report worse experiences and more illegal moves; I don’t have access to confirm.
Inline links: attempts to make GPT-2 play chess, playing chess with Bing
Zagorsky (2007)1 mentions across 1 issues

Zagorsky (2007) is a recurring person in the Astral Codex Ten archive, appearing 1 times across 1 issues between July 31, 2025 and July 31, 2025. The archive places it in contexts such as "Zagorsky (2007) says an extra IQ point means $234-$616/year". It most often appears alongside 23andMe, 23andme, Alex Young.

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Zagorsky (2007)
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1
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1
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July 31, 2025
Last seen
July 31, 2025
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Suddenly, Trait-Based Embryo Selection
July 31, 2025 · Original source
…and the section of the post called “Antagonistic Pleiotropy” for more. However, this paradoxical benefit is only true for a few conditions like diabetes - for everything else, selecting on health index does better than you would naively think, but still does not decrease the risk of a given condition as much as selecting against that condition directly. 3That is, new mutations in that particular baby, as opposed to older mutations already present in the parents. 4Conflicts of interest: I have used Orchid’s and Herasight’s products on my own embryos (not the ones used to conceive my existing kids, but for a potential third child), employees of Genomic Prediction and Herasight have been extremely helpful in contributing expertise to ACX posts on genetics, and I might invest in this field at some point (though haven’t done so yet). This post started as Herasight asking me to write about their white paper, then spiraled out of control. There were some unexpected time pressures and the result is that I didn’t get a chance to run everything in Herasight’s white paper by their competitors as thoroughly as I would like. Although I talked to representatives of all four companies profiled here, I feel like this probably reflects Herasight’s perspective better than other companies’, and that this is a major flaw. If other companies have responses, I’ll publish them. Thanks to all companies involved for their assistance on this article. Finally, I am favorably disposed toward Herasight because of how I learned about them: a professor named Jonathan Anomaly got cancelled from Penn for being too gung-ho about genetic enhancement, and used his newfound freedom to join a very-early-stage Herasight, raise their ambitions, and sell everyone (including me) on the idea. I grew up on a diet of books and movies about mad scientists, and I’m a sucker for a story about a guy named Doctor Anomaly pursuing revenge against the small-minded fools who destroyed his career by creating a race of superbabies. 5The version of the tool I looked at said 5.9 points for five embryos, up to 9 points for twenty embryos. The version of the tool on their current said says 5.3 - 9, so they might have recalculated after I finalized this article. 6Used in quotation marks because these scores were fine for the predictive tasks they were applied for - they just weren’t finding genes that directly caused the outcome of interest. 7Conflict of interest notice: this table was originally unadjusted. A representative of Herasight claimed that this was unfair, because each company used slightly different reporting conventions, and offered to correct for this in a neutral way. I retraced their reasoning, confirmed that the correction did not especially benefit Herasight at the expense of other companies, and accepted the correction. The original unadjusted table is below: Herasight was insufficiently comfortable with Nucleus’ methodology to even be willing to posit a corrected value, so I left their self-reported value in gray. 8Zagorsky (2007) says an extra IQ point means $234-$616/year in higher salary. The midpoint of $425 equals $670 in today’s dollars; assuming a forty-year career, Nucleus’ +1 point estimate is worth $26,800 (vs. $9,249 Nucleus cost) and Herasight’s +6 point estimate is worth $160,800 (vs. $53,250 Herasight cost). 9As part of researching this article, I asked all four major companies about their within-family validation strategies. Here are some details: Genomic Prediction discusses their strategy in this paper. The results are complicated to interpret - the within-family numbers often have such wide error bars that they overlap with both the across-family numbers and with zero - but looking qualitatively it seems like most scores on average lose about 25% of their risk reduction ability (though averages might not be the right way to do this, and some might be much more affected than others). Their website reports unadjusted, not within-family validated numbers; GP says they say this clearly on their site (which is true), Herasight counters that they still present their numbers as applicable to embryo selection (which is also true). To get the most applicable-to-embryo-selection numbers, you might want to adjust GP’s stated numbers down somewhat; it’s hard to say exactly how much, but maybe 20 - 25%?
Inline links: 3, 4, 5, 6, 7, https://substackcdn.com/image/fetch/$s_!Vimq!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fca0f1f15-268d-465a-a70f-b7f1173c6111_566x166.png, https://substackcdn.com/image/fetch/$s_!3B0A!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Faccc7a65-b142-4bf6-927d-53eb607d71ef_552x155.png, 8, 9, in this paper
Zahmakibo1 mentions across 1 issues

Zahmakibo is a recurring person in the Astral Codex Ten archive, appearing 1 times across 1 issues between December 31, 2025 and December 31, 2025. The archive places it in contexts such as "Zahmakibo writes: “There is one anomaly, which is that I remember people complaining". It most often appears alongside 1955, 4chan, AARP.

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Zahmakibo
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December 31, 2025
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December 31, 2025
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Highlights From The Comments On Vibecession
December 31, 2025 · Original source
Zahmakibo writes:
Zaid Jilani1 mentions across 1 issues

Zaid Jilani is a recurring person in the Astral Codex Ten archive, appearing 1 times across 1 issues between April 22, 2025 and April 22, 2025. The archive places it in contexts such as ""Zaid Jilani points out that if immigrants don’t get a right to due process"". It most often appears alongside 80,000 Hours, @msamalam, A Ketamine Addict’s Perspective On Musk.

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Zaid Jilani
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April 22, 2025
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April 22, 2025
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Links For April 2025
April 22, 2025 · Original source
Zaid Jilani points out that if immigrants don’t get a right to due process, citizens also don’t get a right to due process, because the government can kidnap citizens, claim they’re immigrants, and the citizens can’t prove otherwise since they don’t get due process.
Inline links: Zaid Jilani
Zan Tafakari1 mentions across 1 issues

Zan Tafakari is a recurring person in the Astral Codex Ten archive, appearing 1 times across 1 issues between December 01, 2023 and December 01, 2023. The archive places it in contexts such as "Zan Tafakari has a roundup of responses to Marc Andreessen’s “Techno-Optimist Manifesto”". It most often appears alongside Abraham Davenport, AI Policy Institute, Arizona.

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Zan Tafakari
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Links For November 2023
December 01, 2023 · Original source
27: Zan Tafakari has a roundup of responses to Marc Andreessen’s “Techno-Optimist Manifesto”; I think the thalidomide objections are bad (the backlash against thalidomide has harmed far more people than thalidomide itself, just like with nuclear power), but maybe there are some useful tidbits in there. Ezra Klein has a response of his own called The Chief Ideologist Of The Silicon Valley Elite Has Some Strange Ideas (I almost phrased that as “the chief ideologist of the Brooklyn elite has a response…”, but there’s no need to sink to their level).
Inline links: a roundup of responses to Marc Andreessen’s “Techno-Optimist Manifesto”, The Chief Ideologist Of The Silicon Valley Elite Has Some Strange Ideas
Zang Wenzhong1 mentions across 1 issues

Zang Wenzhong is a recurring person in the Astral Codex Ten archive, appearing 1 times across 1 issues between September 01, 2023 and September 01, 2023. The archive places it in contexts such as "In three acts Zang Wenzhong [the high minister in charge at the time]". It most often appears alongside 536 BC, ACX, Ai Jiang.

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Zang Wenzhong
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Your Book Review: Zuozhuan
September 01, 2023 · Original source
Confucius said, “In three acts Zang Wenzhong [the high minister in charge at the time] was ignoble in spirit and in three acts was unwise. He kept Zhan Qin in a lowly position, he abolished the six customs barriers, and his concubines wove rush mats for sale. These are three ignoble acts. He fashioned meaningless vessels, he allowed a violation of the sacrificial order, and he sacrificed to the seabird Yuanju. These are the three unwise acts.”
Zanzibar BuckBuck McFate1 mentions across 1 issues

Zanzibar BuckBuck McFate is a recurring person in the Astral Codex Ten archive, appearing 1 times across 1 issues between January 21, 2026 and January 21, 2026. The archive places it in contexts such as "Zanzibar BuckBuck McFate writes". It most often appears alongside 4chan, 80,000 Hours, @Ashwin V.

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Highlights From The Comments On Scott Adams
January 21, 2026 · Original source
I have seen people try to walk this back by saying Adams only meant they would be persecuted in some way that was metaphorically equivalent to hunting, but I feel like “good chance you will be dead within the year” is saying he means the kind of hunting which literally kills you, and “police will stand down” means that it will be the sort of extremely illegal thing that police would normally react to. I have seen other people try to link this to examples of Republicans actually getting killed, such as Charlie Kirk. But Adams was telling his readers there was “a good chance” that “they” would be dead within a year, which I think implies this fate happening to a significant proportion of ordinary Republicans, not just one prominent person. Also, Kirk was five years after the comment was posted. Can we dismiss this as a joke? I think Adams has used the manipulation technique of saying things that might or might not be jokes and then strategically sticking to them or saying “What? Me? I was only joking! Haha! You can’t take a joke!” depending on which was more convenient to him at that exact second, enough times that I’m not comfortable letting him have that escape. Also, when I was replying to Joel Pollak about this, I happened to glance at his Twitter account, and one of the top tweets was a repost of someone saying that “The Democrat playbook is to arrest every single person who disagrees with them”. I think if I forced Pollak into some kind of extremely literal frame of mind - maybe asked him to bet money on whether I could tweet the words “the Democrats are wrong about immigration” in my Democrat-controlled state without getting arrested - he would admit that, okay, they don’t want to arrest literally every single person who disagrees with them. He was exaggerating for effect, probably in much the way he’s going to say that Scott Adams was exaggerating for effect. You say stuff like “The Democrats are going to HUNT YOU DOWN and LITERALLY MURDER YOU. They will TORTURE YOUR FAMILY and RAPE YOUR DAUGHTER and EAT YOUR PETS and TURN YOUR HOUSE INTO A CHURCH OF SATAN”, and what you mean is “I disagree with the Democrats and sometimes they go overboard cancelling people”. I have a post called If It’s Worth Your Time To Lie, It’s Worth My Time To Correct It. My thesis is that tolerating claims of “directional correctness” - the thing where someone asks to get a pass because even if they said wasn’t literally true, it “points to” an “emotionally correct” thing - is eventually totally corrosive. It means everyone ratchets up their claims to the highest level they think they can get away with (ie walk back later if challenged, as a motte and bailey). And then you end up with this miasma where maybe 5% of people totally believe you, and 50% of people sort of absorb the connotation and think something like that is true, and then people get terrified of the Democrats and think of them as monsters and treat politics as an existential struggle where they will genuinely get arrested or murdered unless they do it to the Democrats first, and then you get a civil war or something. I think Adams and Pollak’s milieu has in fact reached this point, and their love for these kinds of exaggerations is a big part of the cause. Adams was one of the funniest people in the world. If he was actually telling a joke, you could tell by the fact that you were laughing hysterically. “Democrats will hunt and kill you” isn’t funny. I’ll refrain from judgment about whether it was Adams’ sincerely held belief, some kind of annoying manipulation attempt, or whether Adams even recognized a difference between the two. But I think judging him on the fact that it didn’t happen is completely within bounds. … 3: Comments On The Substance Of The Piece … Zanzibar BuckBuck McFate writes: This business where boomers are tolerant of contradictions and find them amusing whereas millennials are horrified is a dynamic I've noticed as well, it seems to be true in politics also, I myself feel this hunger to be authentic all the time. I think it has something to do with the difficulty children have in putting negativity in context. They can't distinguish between a parent having a bad day and venting, or having an existential crisis. So the 50s guy was half right - you don't have to love your boss in your heart of hearts but careful what you say to your kids. Feral Finster writes: » “This is the basic engine of Dilbert: everyone is rewarded in exact inverse proportion to their virtue. Dilbert and Alice are brilliant and hard-working, so they get crumbs. Wally is brilliant but lazy, so he at least enjoys a fool’s paradise of endless coffee and donuts while his co-workers clean up his messes. The P.H.B. is neither smart nor industrious, so he is forever on top, reaping the rewards of everyone else’s toil. Dogbert, an inveterate scammer with a passing resemblance to various trickster deities, makes out best of all.” Compare with the famous observation that executives are sociopaths, management are clueless, and the workers losers. Yeah, it’s interesting to compare Rao and Adams. Rao formulated his Gervais Principle as a specific response to Adams’ Dilbert Principle, which I guess means Rao thought Adams got it wrong. Did he? The Pointy Haired Boss seems to go back and forth between Clueless and Sociopath, which is probably why Rao thought Adams’ work fell short. Dogbert is clearly Sociopath, but has no permanent role in the corporation, and doesn’t really represent a real thing you can be - his character was a ridiculous scammer who succeeded at near-impossible endeavours (like convincing people he was a Nostradamus-style mystical prophet) because the logic of the strip demanded it. Later, Adams foregrounded the CEO character more, maybe to create a purer Sociopath, letting the Boss go closer to Clueless. This is making me somewhat regret accusing Adams of wanting to be the Pointy-Haired Boss. It would have been fairer (and less of an accusation/surprise) to accuse him of wanting to be Dogbert. But again, Dogbert doesn’t represent a real thing you could be, which might have been why the PHB made a better metaphor. (contra my claim, the cover of Win Bigly shows a mashup of Dogbert and Trump. Fine, Dogbert is a thing one person can be.) You can read my full review of The Gervais Principle here. cincilator writes: Scott Alexander, former tribune of nerds now says that the sneerclub was right about everything all along? I didn’t expect that, let me tell you. Several people interpreted me as attacking nerds. I disagree - I think I was attacking self-hating nerds, because nerdiness is fine and you shouldn’t have to hate yourself for it. To spell it out more explicitly: All nerds must eventually realize they’re not going to immediately dominate everything by intellect alone. This isn’t because intellect isn’t great, it’s because 1) it’s only one of many skills, and 2) you probably aren’t even the person with the most intellect. Again, every mildly-talented person has to face this realization, whether it’s a nerd realizing he won’t be the next Einstein or a jock realizing he won’t be the next LeBron. If someone deals with this using denial (one of Freud’s maladaptive defenses), you get the nerd who says no, I really am the next Einstein, ie a crackpot, aka the sort of person who gets featured on Sneerclub. If they deal with it using reaction formation (another of Freud’s maladaptive defenses), you get the self-hating nerd, aka the sort of person who joins Sneerclub4. If they just deal with it maturely instead of spinning up maladaptive defenses against it, they’re a nerd who is hopefully good-natured and accepting of their nerdiness, and hopefully does some good work in some specific small area, and changes the world in some specific small way (or some very large way, if they can work together with other people and get lucky). Bugmaster writes: I think Adams is basically correct. Yes, facts and evidence do exist and are real; but they have virtually no impact on anything socially important -- i.e., on anything important whatsoever. Memes and charisma and persuasion are what matters if you want to achieve life goals that extend beyound yourself and your immediate family. I worry that Adams (and you) are doing something where unless the average person can solve every problem by facts and intelligence alone, then facts+intelligence lose and memes and persuasion win. But the average person also can’t solve every problem by memes+persuasion alone! If Dilbert is an 80th percentile nerd, the 80th percentile persuader is - I don’t know, a used-car salesman? Dilbert’s probably earning more money, especially nowadays when he could make L5 at Google. And if Donald Trump is a 99.9999th percentile persuader, the 99.9999th percentile nerd is Ilya Sutskever. Probably most people would slightly prefer being Trump to Sutskever, but Sutksever does have a couple billion dollars, plus the more ethereal rewards of genius; it still seems like a pretty good deal. I also think you’re doing a sort of black-and-white thinking here. Every day, great persuaders like Sam Bankman-Fried and Elizabeth Holmes end up in jail, because in fact the things that they said were true were not true. Every day, smooth-talking charismatic manipulators successfully seduce the girl into bed with them, then totally fail to turn it into a happy stable marriage, because after a few years even the dumbest woman catches on and figures out whether her mate provides real value or not. Even Donald Trump has only a 37% approval rating, because he can’t make “we should alienate our allies over Greenland” sound plausible to most of the American people. When someone’s very good at it, persuasion sometimes helps them blur facts around the edges. But that’s it. Nobody except Scott Adams and a few psychotherapists ever go to hypnotist school. Most don’t even go to any formal persuasion classes. That’s because hypnotism/persuasion isn’t really a lifehack that helps you win all the time at everything. If the world’s best hypnotist asked a room of VCs for money with a stupid business plan, he would probably fail. This isn’t to say persuasion is useless, and in certain fields it can be very powerful indeed. But let’s not go crazy and start worshipping it. The grass is always greener on the other side. The nerd sits in his cubicle and thinks “If only I were more charismatic.” But the salesman with the bright teeth and the firm handshake thinks “Man, I bet I could get out of this dead-end job if only I were smarter.”5 … 4: The Part On Race And Cancellation (INCLUDED UNDER PROTEST) … Ilya Lozovsky writes: Ninety percent of this essay is brilliant — smarter and realer than anything anyone else has written about Adams — but the end lost me. It's too generous, to the point of being a whitewash. Adams was vicious and hateful and played a material role in convincing Americans to vote for actual fascism. I don't think it's right to "hand it to him." JJ McCullough (JJM’s Shortstack) writes: Good essay, but I think you kinda yadda-yadda'd away his racist rant, which was extremely explicit and extended. I think it was the opposite of a "bog-standard cancellation," which we think of as being a slightly unfair, overzealous policing of an at least slightly subjectively offensive comment, often from years ago. But Scott went on quite a long diatribe about why black people, as a group, are dangerous and undesirable to be around, and why he, personally, goes out of his way to avoid them. Some conservatives have tried to use "bog-standard" anti-woke logic in defending him, but no, his comments really are quite explicitly and undeniably racist, if that term has any useful definition at all. Alex Wotbot writes: Now, you quoted Adams saying: “the best advice I would give to white people is to get the hell away from black people; just get the fuck away” If this was the intended point, does it really make sense that only the far-left freaked out? It’s kind of important to mention this was within a hypothetical. Suppose a survey reported that 26% of a population believes “The phrase ‘It’s OK to be blonde’ is hate speech” and another 21% weren’t sure if they agree with the statement or not. Now suppose you were blonde, would you hang around that population? Now go read the February 2022 Rasmussen Reports survey. Please do better than this, I don’t want to have to Gell-Mann memoryhole this. Many people had strong opinions on this, so I have to respond to it. But first, I want to make it extra clear in capital letters: I AM DOING THIS IN THE COMMENTS POST, TO RESPOND TO YOUR COMMENTS, AND NOT BECAUSE I THINK IT IS THE MOST IMPORTANT THING. Certain people screenshotted the one paragraph of my ten thousand word essay that discussed this and posted it on Twitter, in order to make it look like I was joining in some kind of chorus of liberals reducing Adams to his worst moment. I posted what I thought was a no-nonsense, factual description of what happened, in order not to be accused of hiding it or covering it up. It was the least important part of my essay, I’m aware that writing about it at all opens me to attack from both sides, and I discuss it here only to respond to all of you who wanted to know my opinion on it. Just don’t screenshot it on Twitter and say “LOOK SCOTT IS STILL HARPING ON THE RACE THING”, that’s all I’m asking. That having been said… To make sure we’re all on the same page - Adams’ comments were prompted by this poll, conducted February 2023. The question was: “Do you agree or disagree with this statement: ‘It’s OK to be white’” Among blacks, 53% agreed, 26% disagreed, and 21% were “not sure”. Among whites, the numbers were 81/7/13. Here’s the video of Adams’ comments: Transcript: If nearly half of all blacks are not okay with white people - according to this poll, not according to me - that’s a hate group. And I don’t want to have anything to do with them. And I would say, based on the current way things are going, the best advice I would give to white people is to get the hell away from black people. Just get the f**k away. Wherever you have to go. Just get away. Cause there’s no fixing this. This can’t be fixed. You just have to escape. That’s what I did. I went to a neighborhood with a very low black population. Because unfortunately, there’s a high correlation between the density - this is according to Don Lemon, here I’m just quoting Don Lemon, who said when he lived in a mostly black neighborhood, there were a bunch of problems he didn’t see in white neighborhoods. So even Don Lemon sees a big difference, for your quality of living, based on where you live and who’s there. So I think it makes no sense whatsoever as a white citizen of America to try to help black citizens anymore. It doesn’t make sense. Because there’s no longer a rational impulse. And so I’m… I’m gonna, uh, I’m gonna back off from being helpful to black America, because it doesn’t seem like it pays off. Like I’ve been doing it all my life, and I’ve been… the only outcome is I get called a racist. That’s the only outcome. [cackles] It makes no sense to help black Americans if you’re white… it’s over. Don’t even think it’s worth trying. Totally not trying. Is this racist? I have a piece called Against Murderism, where I talk about why it’s so hard for people to agree on questions about “racism”. The summary: although it would be possible to have someone be purely, axiomatically racist - having it be a premise of their reasoning that they hate black people - in practice few people are like this. More typically, people have some argument more like: I don’t like [specific bad thing]
Inline links: https://substackcdn.com/image/fetch/$s_!KA_U!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fa2cb6162-0262-4c4c-8048-e8355f38967a_900x280.gif, If It’s Worth Your Time To Lie, It’s Worth My Time To Correct It, writes, writes, the famous observation that executives are sociopaths, management are clueless, and the workers losers, The Gervais Principle, writes, 4, writes, 5, writes, JJM’s Shortstack, writes, writes, this poll, Against Murderism
Zavascki1 mentions across 1 issues

Zavascki is a recurring person in the Astral Codex Ten archive, appearing 1 times across 1 issues between November 23, 2021 and November 23, 2021. The archive places it in contexts such as ""aHR 4.73 [1.15-19.41] [ Zavascki ]"". It most often appears alongside 1/6 insurrectionists, Ahmed, Alabama.

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Zavascki
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1
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1
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November 23, 2021
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November 23, 2021
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Highlights From The Comments On Ivermectin
November 23, 2021 · Original source
Author disregards the dramatically higher mortality for Gamma vs non-Gamma variants (aHR 4.73 [1.15-19.41] [Zavascki]), instead concluding that higher mortality indicates fraud in one instance, while in another instance assuming that the related confounding by time in the Together Trial is not significant.
Inline links: Zavascki
Zbigniew Lukasiak1 mentions across 1 issues

Zbigniew Lukasiak is a recurring person in the Astral Codex Ten archive, appearing 1 times across 1 issues between November 20, 2023 and November 20, 2023. The archive places it in contexts such as "Zbigniew Lukasiak on the social usefulness of religion". It most often appears alongside ACX, Astralcodexten Com, Awais Aftab.

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Zbigniew Lukasiak
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1
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1
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November 20, 2023
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November 20, 2023
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Open Thread 303
November 20, 2023 · Original source
1: Some good comments on the Rene Girard book review. Given the generally anti-Girard reception, I was grateful for the few people who stepped up to defend or explain him. Skaladom recommends a professional Girard exegete named Johnathan Bi (lectures here). Neil Scott notes that Sam Kriss has a recent Girard article. Deiseach on memetic crisis and Girard’s theology, Zbigniew Lukasiak on the social usefulness of religion, and Hal Johnson suggesting other books. And thanks to Bill Benzon for highlighting that Tyler Cowen considers Girard one of the top twenty thinkers of the second half of the 20th century. I would love to know more about Tyler’s interpretation of Girard and the single-victim process. Maybe in the context of recent events?
Inline links: the Rene Girard book review, anti-Girard reception, recommends, lectures here, notes, a recent Girard article, memetic crisis, Girard’s theology, the social usefulness of religion, suggesting other books, for highlighting, considers Girard
Zeihan1 mentions across 1 issues

Zeihan is a recurring person in the Astral Codex Ten archive, appearing 1 times across 1 issues between May 21, 2021 and May 21, 2021. The archive places it in contexts such as "Zeihan’s primary models are influenced by his geographic-based perspective"; "Zeihan refers to this as “when life sucked”"; "Zeihan concludes a chapter on America with the “nuts and bolts” of how countries rule the world". It most often appears alongside 1992 treaty, ACX, Africa.

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Zeihan
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1
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1
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May 21, 2021
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May 21, 2021
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Your Book Review: The Accidental Superpower
May 21, 2021 · Original source
In The Accidental Superpower: The Next Generation of American Preeminence and the Coming Global Disorder (2014), Peter Zeihan predicts the future of world politics and economic development in a way that an ACX fan would appreciate. He puts a timeline on it. The book isn’t about “some hazy distant future after we’re all dead and gone, but the future we will all be living in for the next fifteen years of our lives.” Zeihan’s subtitle hints at his big and bold thesis, which predicts “the dissolution of the free trade order, the global demographic inversion, the collapse of Europe and China,” which “is all just a fleeting transition” to a world largely abandoned by America.
Inline links: The Accidental Superpower: The Next Generation of American Preeminence and the Coming Global Disorder
People have fun making predictions like this (and mocking those who get things spectacularly wrong). With money and fame available to people whose predictions turn out right, and the ease with which we forget bad predictions, we should expect many such visionaries. However, regardless of whether you agree with Zeihan’s particular vision, The Accidental Superpower presents a set of analytical tools that should be useful for anyone interested in little questions like which countries will obtain power and wealth in the future, and which will collapse in war and poverty. (In case you didn’t catch it from the title, Zeihan says that America is going to be the biggest winner in the world to come.)
Zeihan’s primary models are influenced by his geographic-based perspective on how our world works. As he puts it in the introduction, “Geopolitics is the study of how place [rivers, mountains, etc.] impacts… everything.” 1 Early chapters discuss what he calls the balance of transport, which is roughly easy transport within a country (for economic development and forming political and cultural ties) and hard transport from outside of it (for defense). These transport issues are inherently tied to geography. What’s the best way to move things? Water-based transportation is extremely cheap. Think 17 cents per container mile vs. $2.40 for semis on an American highway, with a more extreme disparity for other countries, trade between continents, and populations in hard-to-access places. On the defensive side of that equation, geographic features on borders such as deserts, mountains, and oceans get Zeihan’s attention.
Inline links: 1
Zelaya1 mentions across 1 issues

Zelaya is a recurring person in the Astral Codex Ten archive, appearing 1 times across 1 issues between April 14, 2021 and April 14, 2021. The archive places it in contexts such as "Zelaya ordered the military to assist in holding the referendum". It most often appears alongside Alaska, America, Amisulpride.

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Zelaya
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1
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1
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April 14, 2021
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April 14, 2021
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Prospectus On Próspera
April 14, 2021 · Original source
In 2009, Honduras' leftist-ish President Manuel Zelaya proposed a referendum to change the Constitution, which his opponents interpreted as a plot to remove term limits and rule indefinitely. The Supreme Court ruled against him, Zelaya ordered the military to assist in holding the referendum anyway, and the military held a coup instead. They appointed the next person in the line of succession the interim president, then held tense elections which were partially boycotted by Zelaya supporters and of debated legitimacy. Conservative candidate Porfirio Lobo Sosa won and became president. Lobo's chief of staff Octavio Sanchez stumbled upon the TED talk where Romer discussed charter cities and invited him to Honduras for negotiations.
Zelensky1 mentions across 1 issues

Zelensky is a recurring person in the Astral Codex Ten archive, appearing 1 times across 1 issues between March 01, 2022 and March 01, 2022. The archive places it in contexts such as "Will Zelensky still be President of Ukraine on 4/22/22? 42% chance"; "will Zelensky be killed or captured?". It most often appears alongside ACX, Afghan government, Aleppo.

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Zelensky
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1
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1
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March 01, 2022
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March 01, 2022
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Ukraine Warcasting
March 01, 2022 · Original source
Current conventional wisdom is that the invasion was a miscalculation on Putin’s part, after he surrounded himself with so many yes-men that he lost touch with reality. But Ukraine miscalculated too; until almost the day of the invasion, Zelenskyy was saying everything would be okay. And if there’s a nuclear exchange, it will be because of miscalculation - I don’t know what the miscalculation will be, just that nobody goes into a nuclear exhange because they want to. Preserving people’s access to reality and helping them avoid miscalculations are peacekeeping measures, sometimes very important ones.
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This is the most-predicted relevant question on Metaculus right now. The first day of the war, the market predicted as high as 90%; as people realized the strength of Ukrainian resistance, it fell to 80. Mid-Saturday there was a sudden drop from 78% to 72%, after some combination of a defiant Zelenskyy speech and a report that Russian paratroopers had been repelled. Since then it’s barely budged.
— Will Zelensky still be President of Ukraine on 4/22/22? 42% chance
Zendaya1 mentions across 1 issues

Zendaya is a recurring person in the Astral Codex Ten archive, appearing 1 times across 1 issues between February 22, 2022 and February 22, 2022. The archive places it in contexts such as "Effective altruist organizations as Zendaya outfits". It most often appears alongside 1984, Anatoly Karlin, AnechoicMedia.

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Zendaya
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February 22, 2022
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February 22, 2022
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Links For February
February 22, 2022 · Original source
14: You’ve probably heard statistics about how 50% of transgender youth attempt suicide before age 21. This paper tries to analyze the situation in more depth. The 50% number usually comes from surveys, but there’s some evidence people exaggerate on surveys, rounding up “I think about it a lot” to “I attempted”. The authors gather data on completed suicides among trans people, and find that they’re about 0.01%/year (which is about 5x the cisgender rate). If we suppose that people have about 5 years between becoming transgender and turning 21, then the 50% attempted suicide rate → 0.05% completed suicide rate implies that 1/1000th of the youth who report attempting suicide on surveys complete suicide - which sounds about right to me [but see this comment for a critique] 15: Gwern on the failures of 20th century eugenics. I’ve previously linked a piece about how, aside from the general moral failure, the 20th century eugenicists got lots of implementation details really wrong. Gwern adds to the picture: they had a purely Mendelian (as opposed to polygenic) model of intelligence, and felt that bad traits were probably caused by single recessive genes. This dichotomized the population in a way that contributed to the moral problems - if IQ is truly a continuum, then someone with 120 IQ might still wonder if they were “inferior” to someone with 130 IQ, in a way that made them feel some sympathy to someone with 80 IQ who was being pronounced “inferior” by the eugenicists of the time. But instead, they thought some people had the specific recessive “low intelligence” gene, those people could be “cleansed” from the population, and then everyone else would be fine! It also prevented them from considering improving the populace by encouraging intelligent people to breed more (as opposed to sterilizing unintelligent people) - this wouldn’t eliminate the recessive variants that were causing all the trouble! I’m confused how they could have believed this even with the limited knowledge of the time; this was long after Galton had proven that genius was genetic, and once you have genetic genius you know there’s more going on than Mendelian inheritance of subnormality. 16: Sexual selection bridges peaks in adaptive fitness landscapes 17: NFTorah: “The Torah [is] the original blockchain”. I think it’s funny that this exists, but it’s exactly what you would expect, and you don’t have to click on the link. 18: More IRB nightmares. 19: @ethanbdm When we piloted a public lottery to evaluate cash transfers in Liberia, the potential recipients arranged beforehand to insure one another. After the randomization and grant, the winners compensated the losers and unraveled the field experiment.","username":"cblatts","name":"Chris Blattman","profile_image_url":"","date":"Tue Jan 18 19:01:29 +0000 2022","photos":[],"quoted_tweet":{},"reply_count":0,"retweet_count":77,"like_count":678,"impression_count":0,"expanded_url":{},"video_url":null,"belowTheFold":true}" data-component-name="Twitter2ToDOM"> 20: DeepMind made a programming AI that was able to participate in a human coding competition and place around the middle. Nostalgebraist gives his thoughts: “impressed with the raw performance, not massively surprised, not sold that it implies anything big in particular”. A lot of people will be watching whether it can win programming competitions outright a year or two from now, though I bet their perspectives on how relevant this is for AI takeoff speeds will be pretty mixed. 21: Effective altruist organizations as Zendaya outfits. 22: Brain Efficiency: Much More Than You Wanted To Know. “Why should we care? Brain efficiency matters a great deal for AGI timelines and takeoff speeds, as AGI is implicitly/explicitly defined in terms of brain parity.” 23: I’m not going throw out my copy of The Case Against Education just yet - I haven’t checked this study but I bet there are lots of possible confounders. Still, this would be fun for somebody more interested to analyze in depth: 24: Best of Scott Sumner archives: There’s Only One Sensible Way To Measure Economic Inequality. “You cannot put the burden of a tax on someone unless you cut into his or her consumption. If … tax increases did not cause Gates and Buffett to tighten their belts, then they paid precisely 0% of that tax increase. Someone else paid, even if they wrote the check. If they invested less due to the tax, then workers might have received lower wages. If they gave less to charity then very poor Africans paid the tax.” 25: The latest in the Greater Male Variability Hypothesis: Harrison, Noble, and Jennions publish a meta-analysis failing to find evidence of greater male variability in the personality of non-human animals. Del Giudice and Gangestad have a rebuttal saying that they were underpowered to detect it even if it did exist, plus noting the ways that media coverage of this study was incredibly irresponsible even by its own terms. 26: Some recent critiques of Cook (2014) on racial violence vs. black patents, including Michael Wiebe challenging the violence measures and AnechoicMedia arguing that the black patent measure declines right when switching from one (more complete) dataset to another (less complete) one. Rebuttal by Brad DeLong here, he argues that Cook uses multiple methods and some of them don’t have this problem. Relevant since Cook is now being considered for the Federal Reserve; see eg this Wall Street Journal editorial against. 27: Claim: 31% of British people say they have seen or met Queen Elizabeth (this seems plausible to me, I would answer ‘yes’ to this because she visited Ireland when I lived there, I watched the parade in her honor, and I could vaguely glimpse her on the inside of her car). 28: This couple-of-month-period in wokeness: Scientific American attacks late biologist EO Wilson, in a screed whose highlight is calling him problematic for describing ants as having “colonies”. This is part of a more general (and surprisingly fast) pivot at Scientific American from real science to culture warring; when even Eric Turkheimer thinks you’ve gotten too woke, you’ve gotten too woke.
Inline links: This paper, this comment, the failures of 20th century eugenics, bridges peaks in adaptive fitness landscapes, NFTorah:, IRB nightmares, DeepMind made a programming AI, Nostalgebraist, Effective altruist organizations as Zendaya outfits, Brain Efficiency: Much More Than You Wanted To Know, There’s Only One Sensible Way To Measure Economic Inequality, Harrison, Noble, and Jennions, Del Giudice and Gangestad, challenging the violence measures, arguing that the black patent measure declines, here, this, seen or met Queen Elizabeth, highlight, even Eric Turkheimer thinks you’ve gotten too woke
Zeng1 mentions across 1 issues

Zeng is a recurring person in the Astral Codex Ten archive, appearing 1 times across 1 issues between June 26, 2025 and June 26, 2025. The archive places it in contexts such as "anti-hereditarians disagree. They cite papers like Zeng which measure". It most often appears alongside Aftab, Alex Young, Arthur Jensen.

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Zeng
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June 26, 2025
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June 26, 2025
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Missing Heritability: Much More Than You Wanted To Know
June 26, 2025 · Original source
For example, educational attainment is 50% uncorrelated with direct genetic effects. You need to square this to figure out what percent is causal; when you do that, you find that the polygenic score that explained 14% of EA is only 4%pp direct genes, with the other 10%pp being nondirect5 confounders. So yes, it seems like most polygenic scores that don’t validate within families are confounded. However unhappy we previously were that we had only found 14% of genes for EA (vs. 40% expected), we should now be much more unhappy - we really only know 4% of genes that directly cause EA. On the other hand, you might say - so before we only knew 14%pp out of 40%. Now we only know 4%pp out of 40%. This is discouraging, but it doesn’t fundamentally change what we know about nature vs. nurture. Both 4%pp and 14%pp are less than 40% - with either number, we must be missing something or doing something wrong. Probably that’s insufficient sample size. We’ll keep working on sample size and other things, and eventually scrounge up the missing 26%pp or 36%pp or whatever of the variance, so this doesn’t change anything. All it means is that one predictive method that the average person never knew about in the first place doesn’t work as well as we thought. Who cares? Not doctors. So far this research has only just barely begun to reach the clinic. But also, all doctors want to do is predict things (like heart attack risk). They don’t care if they use causal vs. nondirect genes. It doesn’t matter if you’re “only” at higher risk of heart attack because you’re black, or Norman, or because your parents read books to you - you still need more heart attack medication! Polygenic embryo selection companies should care. They offer polygenic scores that can be used to select healthier or smarter embryos. If the predictors they use rely partly on variants that aren’t causal within families, their real benefits could be far lower than advertised. I talked to one of these companies, who said they’d already adjusted for these effects and expected their competitors had too - the proper antidote to this problem, sibling controls, is a natural choice when you’re literally picking between siblings. The biggest losers are the epidemiologists. They had started using polygenic predictors as a novel randomization method; suppose, for example, you wanted to study whether smoking causes Alzheimers. If you just checked how many smokers vs. nonsmokers got Alzheimers, your result would be vulnerable to bias; maybe poor people smoke more and get more Alzheimers. But (they hoped) you might be able to check whether people with the genes for smoking get more Alzheimers. Poverty can’t make you have more or fewer genes! This was a neat idea, but if the polygenic predictors are wrong about which genes cause smoking and what effect size they have, then the less careful among these results will need to be re-examined. But the reason I spent so much time on the subject here is that this has confused a lot of people into thinking heritability itself was confounded and is actually just 4%. When I read my first few blog posts on these findings, I came away thinking they were claiming to have discredited twin studies and heritability. And although I take partial ownership of my own poor reading comprehension, I maintain that the way that the new anti-hereditarians discuss this is pretty bad. For example, Turkheimer’s treatment of the Tan study above is called Is Tan Et Al The End Of Social Science Genomics?, and includes passages like: The median [direct genomic effect] heritability for behavioral phenotypes is .048. Let that sink in for a second. How different would the modern history of behavior genetics be if back in the 80s one study after another had shown that the heritability of behavior was around .05? When Arthur Jensen wrote about IQ, he usually used a figure of .8 for the heritability of intelligence. I know that the relationship between twin heritabilities and SNP heritabilities is complicated, and in fact the DGE heritability of ability is one of the higher ones, at .2336. But still, it seems to me that the appropriate conclusion from these results is that among people who don’t have an identical twin, genomic information is a statistically non-zero but all in all relatively minor contributor to behavioral differences. And comments included things like: I don’t know if [this study] is the end of social science genomics, but it should certainly be the end of attributing significant genetic influence to behavioral traits (despite the recent scientist-generated cartoons touting genes for “income”). And: There's no doubt that this reported findings have dealt a fatal blow to my conviction that behavioral traits are pre-eminently heritable…This is a remarkable example of an objective statistical fact mercilessly crushing the more subjective experiential sense of "A looks and acts more like B than C because A and B have the same parents." This subjective evidence is almost unshakable and universal in its application as a tried and tested psychosocial heuristic. And yet, here we are. Turkheimer is either misstating the relationship between polygenic scores and narrow-sense heritability, or at least egging on some very confused people who are doing that, and the dynamic was bad enough that I got confused myself for a while. But even more confusing, the new anti-hereditarians actually are saying that lots of behavioral traits have very low heritability! But this point requires different arguments, only tangentially related to these. So let’s move on to… Is Heritability Genuinely Low? (Part 1: GWAS & GREML) In the mid 2010s, when genome-wide association studies (GWAS) based polygenic predictors were getting better every year, it was easy to hope they might reach 40% and close the “missing heritability”. But since then, progress has stalled. The second-to-last tripling of sample size, from 300K to 1M between 2016 - 2018, increased predictive power from 6% → 12%. The last tripling, from 1M to 3M between 2018 - 2022, only increased predictive power from 12% → 14%. If you graph sample size vs. predictive power, it looks like there's an asymptote between 15 - 20% or so. (of which - remember - only 5% is directly causal!) Worse, a mid-2010s technique called GREML allowed researchers to estimate the percent of variance in a trait that comes from the sorts of common genes studied in GWAS, without having to identify the genes involved. A 2016 GREML paper suggested that the maximum share of variance that GWASs of educational attainment could ever discover was about 21% (again, compared to 40% predicted genetic from twin studies). Since unavoidable methodological issues will prevent GWASs from reaching the literal maximum possible, this agrees with the evidence suggesting an asymptote between 15 - 20%. So either twin studies are wrong and traits are less heritable than believed, or the heritability must lie somewhere other than the common genes identifiable by GWAS. What about rare genes? GWASs focus on genetic variation common enough to be worth including in a basic genetic test. Most of this is single nucleotide polymorphisms (“SNPs”). A single nucleotide is one letter of DNA - for example, a C or a G. Polymorphisms are genes that commonly vary in humans - sometimes across races (for example, some humans have a gene for light skin, and other humans have a gene for dark skin), and other times within races (for example, some white people have a gene that makes cilantro taste like soap, and others don’t). So SNPs are single-letter spots in DNA where different people often have different letters. How often? Some people say 1%, but the more practical definition is “often enough that someone has noticed and added it to the test panel”. There are three billion letters in the genome, of which only a few million are commonly-tested SNPs. But these SNP studies have limited7 ability to measure personal mutations and rare variants. Sometimes your parents’ egg and sperm cells mess up copying a nucleotide of DNA, and you get a mutation that isn’t inherited from your ethnic group or even from your subgroup/family line - it’s just some idiosyncratic DNA change that you might be the first person in history to have. Since scientists have never seen this mutation before, they don’t know about it and can’t test for it without doing something more expensive than a simple SNP screen. And SNP studies have limited ability to detect anything more complicated than a single letter changing to another single letter. But some mutations are more complicated structural variants. For example, some bits of DNA get stuck on repeat - one person might have GATGAT, another person might have GATGATGATGAT, and a third person might have fifty GATs in a row. Other bits come out backwards. Sometimes a whole chunk of DNA goes missing, or moves to the wrong place. Occasionally a gene reads The Selfish Gene by Richard Dawkins, takes it too seriously, and evolves some ridiculous trick for spamming itself all over the genome. So if even the best molecular studies seem to be asymptoting around 15-20% of variance in educational attainment, but twin studies suggest it’s 40% genetic, might rare variants and structural variants make up the missing 20-25%pp? This remains a topic of bitter disagreement. On the one side, hereditarians bring up a Darwinian argument: imagine a genetic engineer who hopes to find the genes for educational attainment and edit them to make everyone smart and successful. She looks harder and harder, becoming more and more exasperated as they fail to materialize. Finally, she realizes she’s been scooped: evolution has been working on the same project, and has a 100,000 year head start. In the context of intense, recent selection for intelligence, we should expect evolution to have already found (and eliminated) the most straightforward, easy-to-find genes for low intelligence. Therefore, everything left should be convoluted or hidden or impossible to work with. So although this requires a sort of god-of-the-gaps argument - where we keep pushing heritability into whatever genes are too weird for existing techniques to detect - there are some reasons to think God really is in the gaps here. And a 2017 paper uses some clever techniques to estimate the share of intelligence variation lurking in hard-to-measure genes and finds it’s more than half: “By capturing these additional genetic effects, our models closely approximate the heritability estimates from twin studies for intelligence and education.” (see also Wainschtein 2022, Sidorenko 2024) The anti-hereditarians disagree. They cite papers like Zeng which measure the strength of selection on intelligence and suggest that it’s too weak to concentrate so much of the variation in rare genes8. And Sasha Gusev mentions Weiner 2023, which finds that in fact rare variants “explain 1.3% (SE = 0.03%) of phenotypic variance on average – much less than common variants” (other experts say that burden heritability only captures some rare variants and is not the right tool for this problem). But it may not even matter, because another set of findings suggests that heritability is genuinely low even when the rare variants are counted. Is Heritability Genuinely Low? (Part 2: Sib-Regression and RDR) Two newer methods, Sib-Regression and RDR, ask: using what we know from genetic studies, how much genetic variation do we think exists, total, across both common and rare genes? On average siblings share 50% of genes. But there’s a little randomness in meiosis, so some siblings might share 40% and others might share 60%. The more genetic influence on a trait, the more similar sibling pairs who share 60% of their genes will be, compared to sibling pairs who only share 40% of their genes. Since 60%-gene siblings and 40%-gene siblings are both equally part of the same family, you can use these numbers to calculate heritability unconfounded by a range of family factors. This is Sib-Regression. If you do a more complicated statistical process to extend the same idea to relatives other than siblings, it’s relatedness disequilibrium regression or RDR. GWAS asks: Looking at common easy-to-study genes, how much variation in a trait have we explained right now? GREML asks: looking at common easy-to-study genes, how much variation could we ever explain? But sib-regression and RDR ask a question more like twin studies: considering all genes, whether common / rare / easy-to-study / hard-to-study, how much variation is there total? This could address the rare variant objection mentioned above. And in many ways, these techniques are better than twin studies - Sib-Regression eliminates many potential biases, and RDR eliminates even more (although it’s harder to pull off, requiring more genetic information and computational resources). These techniques are new and hard-to-use, and only a few published studies have applied them to the sorts of behavioral traits we’re interested in: Young et al (2018) did Sib-Regression and RDR to genetic data from Iceland. Sib-regression found educational attainment = 40% (±15%) heritable, and RDR found 17% (±9%) heritable. Kemper et al (2021) did Sib-Regression only to genetic data from Britain. It found educational attainment = 14% heritable. This number conflicts with the 40% from the Young paper. Why? Unclear, but it could be selection bias - Young’s Icelandic sample was representative of the country; Kemper’s British population were Biobank volunteers who tend tend to be healthier and higher-class than the population at large. Upper-class people may have restricted range in educational attainment, or different factors affecting their educational attainment compared to the overall population. Either way, these are closer to the low estimates from GWAS and GREML (7% direct, 20% total), than to the higher estimates from twin studies (40%, generally presumed direct). And we can no longer use contributions from rare variants to paper over the difference. So what is going on? It seems like we have to accept one of three possibilities: Either something is wrong with twin studies. Or something is wrong with Sib-Regression and RDR (and then we can explain away GWAS and GREML by saying they’re missing rare variants). Or something is wrong with how we’re thinking about this topic and comparing things. What’s Going On? (Part 1: Is Something Wrong With Twin Studies?) Twin studies have dominated discussion of behavioral genetics for decades, so there’s a vast literature investigating their various assumptions and whether something might be wrong with them. Here are some of the assumptions and what the research says about each. Some of these will be duplicates of the GWAS confounders above, but we’ll go through them again anyway to review how they apply to twins. 1: Parents Treat Fraternal And Identical Twins The Same: Twin studies claim that twins are a uniquely powerful genetic laboratory; both fraternal and identical twin pairs have equally concordant environments, but identical twins have more concordant genes. Therefore, the more similar identical twin pairs are relative to fraternal twin pairs, the more heritable a trait must be. But this conclusion falls apart if identical twin pairs actually have more similar environments than fraternal twin pairs do, maybe because parents (knowing their twins are identical) treat them more similarly than they would fraternal twins. Would-be twin-study-discreditors have been trying to argue that this must be true for decades, but it’s always been a kind of quixotic battle. Remember, twin studies find many behavioral traits like IQ are >60% heritable, so you would need to prove not only that parents treat identical twin pairs differently from fraternal, but that this was an overwhelming effect. Parents of identical twins would have to obsessively expose them to the exact same stimuli in the exact same order; parents of fraternal twins would have to send one to the Gifted Advanced Placement Acceleration program while locking the other in a box and force-feeding them lead pellets. Common sense tells us there are no such differences, and studies confirm this: when parents are wrong about their twins’ status (eg they have fraternal twins, but falsely think they’re identical, or vice versa) their trait similarity matches their real status, rather than the incorrect status that determined how their parents treat them; parental treatment explains less than 1% of why identical twin pairs are more concordant (2, 3, 4). See also Felson 2013, which tries to measure environmental similarity and adjust for it, with minimal effects. Are these two cuties monozygotic or dizygotic? Are you sure? (answer) 2: Fraternal And Identical Twins Have Equally Concordant Uterine Environments: Fraternal twins have different sacs in the uterus and use different placentas. Most identical twins share a placenta, and some share an amniotic sac. If trait similarity is caused by sharing a placenta or sac (maybe because the placenta is defective, the fetal brain is starved of nutrients, and so the person has a lower IQ when they grow up), twin studies would falsely read this identical-fraternal difference as genetic. Luckily this is easy to study; not all identical twins share a placenta or sac, so you can cleanly separate the effect of uterine environment from genetics. If you measure enough traits, you can find small deviations in some, but it’s not clear whether this is just multiple testing, and in any case the deviations are small. The best studies suggest this chips off somewhere between 0 - 3% from heritability estimates9. 3: There is little assortative mating: We discussed this one above in the earlier section on GWAS - smart/pretty/kind/whatever people tend to marry other smart/pretty/kind/whatever people. Why would this bias twin study results? Identical twins share 100% of their genes. Fraternal twins ought to share 50% of their genes - but they get half their genes from their mother, and half from their father. In the degenerate case where the mother and father have exactly the same genes (“would you have sex with your clone?”) even fraternal twins will be extremely similar (although not quite identical, since they’ll get different alleles from each clone). In the more plausible case where mothers and fathers are just a little more alike than chance (eg because smart people tend to marry other smart people), fraternal twins will share a genetic tendency towards a trait somewhat more than their 50% shared genes suggest. Since this makes fraternal twin pairs more (genetically) like identical twin pairs, and twin studies assess heritability as the difference in fraternal-identical-twin-pair concordance, this bias would make twin studies underestimate heritability. But this is the opposite of what you would need to “discredit” twin studies - if this bias is true, then everything is more genetic than twin studies think. And unlike the previous two biases, this one seems real and important, so much so that when you adjust for it, the heritability of educational attainment rises from ~40% to ~50%. I’m only mentioning this one here because some anti-hereditarians argue that you can’t trust twin studies because of assortative mating, without mentioning that this can only bias them down. 4: Population stratification: This is often large and worth worrying about, but it applies to identical and fraternal twin pairs equally, and doesn’t bias twin study heritability estimates much (though it might shift the balance between shared and non-shared environment). See eg the sentence around footnote 30 here. 5: Non-additive / “interaction” effects: These are theoretically interesting, but all research thus far has found they are minimal (1, 2). Some experts think this may miss rarer or harder-to-find interactions; we’ll return to this later. 6: “Genetic nurture”, parent-to-child Mentioned above: if there is a gene for reading books to kids, and reading books raises IQ, it will look like a “gene for IQ”. This isn’t as relevant to twin study estimates of heritability, since both identical twins and fraternal twins are equally related to their parents, and any trait caused by genetic nurture wouldn’t differ between them (and therefore would not falsely appear heritable in this design). Rather, they would appear as shared environment. 7: “Genetic nurture”, sibling-to-sibling That is, suppose your sibling’s traits influence your own development. For example, suppose your sibling has a gene that makes them sabotage your schoolwork, causing you to fail and drop out of school early. An identical twin would share this gene with their sibling more often than a fraternal twin, making it look like a “gene for doing badly at school” (since the people who have it do worse at school than those who don’t). Why are we even talking about this? Do we really think it’s a big part of the variance in behavioral traits? Challenging twin study heritability estimates through this route requires inhabiting a weird no-man’s-land where otherwise-invisible genetic and environmental pathways suddenly flare up when you say the magic words “it was done by a sibling”. For example, this requires a strong effect of shared environment - that is, your educational attainment has to depend on whether you’re being sabotaged or not. But in general, shared environmental effects are weak. And it requires a strong effect of genes - that is, this mechanism only works if your sibling’s tendency to sabotage you is highly genetically determined. But we’re deploying this claim to deny that traits like IQ or educational attainment are highly genetically determined. So to get much out of this, the tendency to sabotage siblings would have to be more genetic than other behavioral traits! The reason this convoluted possibility gets brought up so often is that, unlike the more plausible parent-to-child genetic nurture, twin studies can’t rule it out. So if you really want to deny twin studies, this is one of your best bets. But when investigated, this has effects indistinguishable from zero. I’ve been a bit mean in this whole section, because people really like to dismiss twin studies as “Oh, don’t you know, those depend on assumptions, I bet you never considered that assumptions might be wrong”, and then Gish Gallop you with different assumptions until you give up. But scientists have actually done a lot of really good work checking the assumptions and they mostly hold. An alternative way of validating twin studies (brought up by Noah Carl in this article) is to check them against their close cousins, adoption studies and pedigree studies. Pedigree studies investigate large family trees, and check how trait similarity decreases with genetic distance. They avoid twin specific biases (like different treatment of fraternal vs. identical twin pairs, or different prenatal environments), while adding others like assortative mating. Here are the heritabilities of IQ and EA found in pedigree studies10 (see footnote for sources and caveats, and see also here and here for somewhat similar designs): Adoption studies investigate whether adoptees’ traits are more correlated with their adoptive or biological parents. They avoid a large swathe of biases, at the risk of introducing new adoption-related biases of their own (like the possibility that agencies deliberately place adoptive children with parents who are culturally or behaviorally similar, or the possibility that adoptees were adopted late enough to still get some shared environment from their biological parents). Here are the findings of some of the largest and best11: Both straightforwardly confirmed the larger heritability numbers found in twin studies. I would add the evidence from some less formal “adoption studies”12. During residency, I spent a few months working in a child psychiatric hospital for the worst of the worst - kids who committed murder or rape or something before age 18. Many of these children had similar stories: they were taken from their parents just after birth because the parents were criminals/drug addicts/in jail/abusing them. Then they were adopted out to some extremely nice Christian family whose church told them that God wanted them to help poor little children in need. Then they promptly proceeded to commit crime / get addicted to drugs / go to jail / abuse people, all while those families’ biological children were goody-goodies who never got so much as a school detention. When I met with the families, they would always be surprised that things had gone so badly, insisting that they’d raised them exactly like their own son/daughter and taught them good Christian morals. I had to resist the urge to shove a pile of twin studies in their face. This has left me convinced that behavioral traits are highly heritable to a level that it would be hard for any study to contradict. Ultimate source here. Although the study is confusing about this, I think it’s trying to say that almost 90% of subjects were adopted before age 2. But I don’t think studies do contradict this. Given the degree to which their assumptions have been validated, and the level of confirmation from pedigree and adoption studies, I think they have earned a presumption of accuracy. Doubting the twin studies doesn’t seem like a promising route to reconciling the twin-vs-Sib-Regression/RDR discrepancy. What’s Going On? (Part 2: Is Something Wrong With Sib-Regression And RDR?) Sib-Regression is a clever way of avoiding most biases. Its independent variable - the degree to which some sibling pairs end up with slightly more shared genes than others - is even more random and exogenous than the difference between fraternal and identical twins. It can sometimes have biases related to assortative mating (which would falsely push heritability down), but otherwise it’s pretty good. RDR has many of the same advantages, and allows more diverse relationships and so larger sample sizes. It’s hard to think of ways these methods could be wildly off. There is one caveat: although RDR includes most of the rare and structural variants missed by GWAS, in theory it can miss certain ultra-rare variants which are so uncommon that they aren’t shared between some of the relative pairs used in RDR. De novo variants that occurred during the subject’s own conception would be in this category, if the subject didn’t have children or didn’t pass on that gene13. This seems like a pretty small subcategory of genetic variation, and I wouldn’t normally expect that much of importance to be hiding here, but maybe it’s more important than it seems. RDR also doesn’t include much variance caused by statistical interactions between genes. Although we said above that these are usually found to be insignificant, they might be more important in a trait like intelligence that has been under recent evolutionary selection that lops off easily-detectable sources of variance and leaves only the weird obscure ones behind. There’s limited ability for classical Mendelian dominance to affect common variants, but more complicated genetic interactions might still prove important. Overall these are strong methods, and their failure to converge is troubling. If forced to explain them away, we might tell a story like: So far, there is only one RDR study and a few Sib-Regression studies, so we should wait for more data before updating too hard.
Inline links: 5, Polygenic embryo selection, need, Is Tan Et Al The End Of Social Science Genomics?, 6, like, And, 300K, 1M, 3M, A 2016 GREML paper, 7, evolves some ridiculous trick, a Darwinian argument, a 2017 paper, Wainschtein 2022, Sidorenko 2024, Zeng, 8, Weiner 2023, other experts say, meiosis, Young et al (2018), Kemper et al (2021), their trait similarity, matches their real status, 2, 3, 4, Felson 2013, https://substackcdn.com/image/fetch/$s_!r3kV!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fd575f2d6-3619-40e6-9a5e-f9f1ec1399a5_650x422.png, answer, The best studies, 9, seems real and important, here, 1, 2, when investigated, in this article, 10, here, here, https://substackcdn.com/image/fetch/$s_!b3LF!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fc094f9c0-4c71-48cf-89dc-615498d94812_483x51.png, 11, https://substackcdn.com/image/fetch/$s_!XFWU!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F85f433e5-d141-47b7-8dc5-2271925032e9_483x102.png, 12, https://x.com/cremieuxrecueil/status/1935731422205010135, here, 13
Zeng Qihong1 mentions across 1 issues

Zeng Qihong is a recurring person in the Astral Codex Ten archive, appearing 1 times across 1 issues between April 06, 2022 and April 06, 2022. The archive places it in contexts such as "Xi was the client of Zeng Qihong". It most often appears alongside America, American consulate, Attorney General.

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Zeng Qihong
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1
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1
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April 06, 2022
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April 06, 2022
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Dictator Book Club: Xi Jinping
April 06, 2022 · Original source
Xi was a loyal Shanghaier. He was the client of Zeng Qihong, himself a client of Jiang Zemin, and had been party secretary in Shanghai. His loyalty to the faction was unimpeachable.
Zevin1 mentions across 1 issues

Zevin is a recurring person in the Astral Codex Ten archive, appearing 1 times across 1 issues between May 04, 2021 and May 04, 2021. The archive places it in contexts such as "The New York crisis was, Zevin argues, symptomatic of ‘an emerging strategy of disinflation". It most often appears alongside 2008, 9/11 attacks, A Brief History Of Neoliberalism.

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Zevin
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1
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1
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May 04, 2021
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May 04, 2021
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Book Review: A Brief History Of Neoliberalism
May 04, 2021 · Original source
This amounted to a coup by the financial institutions against the democratically elected government of New York City, and it was every bit as effective as the military coup that had earlier occurred in Chile. Wealth was redistributed to the upper classes in the midst of a fiscal crisis. The New York crisis was, Zevin argues, symptomatic of ‘an emerging strategy of disinflation coupled with a regressive redistribution of income, wealth and power’. It was ‘an early, perhaps decisive battle in a new war’, the purpose of which was ‘to show others that what is happening to New York could and in some cases will happen to them’.8
Zeynep Tufecki1 mentions across 1 issues

Zeynep Tufecki is a recurring person in the Astral Codex Ten archive, appearing 1 times across 1 issues between March 15, 2021 and March 15, 2021. The archive places it in contexts such as "Zeynep Tufecki gets some things wrong". It most often appears alongside Apple, Apple silicon, Biden.

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Zeynep Tufecki
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1
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1
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March 15, 2021
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March 15, 2021
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Mantic Monday: Mantic Matt Y
March 15, 2021 · Original source
You don't want a rule that if a pundit ever gets anything wrong, we stop trusting them forever. Warren Buffett gets some things wrong, Zeynep Tufecki gets some things wrong, even Nostradamus would have gotten some things wrong if he'd said anything clearly enough to pin down what he meant. The best we can hope for is people with a good win-loss record. But how do you measure win-loss record? Lots of people worked on this (especially Philip Tetlock) and we ended up with the kind of probabilistic predictions a lot of people use now.
Zhai Liege1 mentions across 1 issues

Zhai Liege is a recurring person in the Astral Codex Ten archive, appearing 1 times across 1 issues between September 01, 2023 and September 01, 2023. The archive places it in contexts such as "In winter, in the twelfth month, the Zhai Liege came". It most often appears alongside 536 BC, ACX, Ai Jiang.

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Zhai Liege
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1
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1
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September 01, 2023
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September 01, 2023
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Your Book Review: Zuozhuan
September 01, 2023 · Original source
In winter, in the twelfth month, the Zhai Liege came.
Zhan Qin1 mentions across 1 issues

Zhan Qin is a recurring person in the Astral Codex Ten archive, appearing 1 times across 1 issues between September 01, 2023 and September 01, 2023. The archive places it in contexts such as "He kept Zhan Qin in a lowly position". It most often appears alongside 536 BC, ACX, Ai Jiang.

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Zhan Qin
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1
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1
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September 01, 2023
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September 01, 2023
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Your Book Review: Zuozhuan
September 01, 2023 · Original source
Confucius said, “In three acts Zang Wenzhong [the high minister in charge at the time] was ignoble in spirit and in three acts was unwise. He kept Zhan Qin in a lowly position, he abolished the six customs barriers, and his concubines wove rush mats for sale. These are three ignoble acts. He fashioned meaningless vessels, he allowed a violation of the sacrificial order, and he sacrificed to the seabird Yuanju. These are the three unwise acts.”
Zhang1 mentions across 1 issues

Zhang is a recurring person in the Astral Codex Ten archive, appearing 1 times across 1 issues between July 08, 2022 and July 08, 2022. The archive places it in contexts such as "Miller, Zhang, and Azrael (2021) explores this question". It most often appears alongside 1/6 insurrection, ACLU, Artifex0.

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Zhang
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1
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1
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July 08, 2022
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July 08, 2022
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Highlights From The Comments On The 2020 Homicide Spike
July 08, 2022 · Original source
Guns are a much bigger factor in violent crime, which increased, then property crime, which decreased. Mass gun sales are a US phenomenon, with per-capita gun ownership in the US being the highest in the world, double the next contender and 5-10 times higher than Canada and Europe. If you're motivated to commit a murder, then whether you currently have a gun seems much more strongly and directly influential than whether you've briefly noticed a police car in the neighborhood in the past week or whether the police seem worried about being cancelled. [separated out unrelated paragraph here into a different section] If increased gun sales largely motivated by the 2020 riots were the most significant factor in the spike, that would be politically inconvenient for both the left and the right- I'd expect good reporting on that to be a bit slim. It would also be politically inconvenient for libertarians, though I hope you'll avoid the mistake of the journalists you criticize, and not allow politics to subconsciously shape how easily you reject hypotheses. I accept I should have put more work in the original post into ruling out gun sales as the cause. That having been said, I still don’t think gun sales were the cause, for four reasons. First, this argument confuses stocks and flows. The flow of guns went up by about 50% over 2020. The stock of guns went up much less. Wikipedia says there are about 400 million guns in the US. That means that in 2019, when people bought about 14 million guns, the total number of guns was going up about 3.5% (and murder was low). In 2020, when people instead bought about 22 million guns, the total number of guns went up 5.5%, so about 2 percentage points more than in a normal year. So this theory requires us to believe that number of guns increasing 3.5% every year from 2015 - 2020 had no effect on the murder rate, but that guns going up 5.5% in 2020 had a very strong effect on the murder rate. Specifically, an extra two percent increase in guns must lead to a 30% increase in murder rates. Why would we believe that? One reason might be if the people buying guns in 2020 were very different from the people buying guns in previous years. For example, if previous gun buyers were collectors who had 100 guns each, but 2020 gun owners were new buyers getting their first gun, then the share of people with at least one gun would go up by more than 2% over an average year. Miller, Zhang, and Azrael (2021) explores this question (thanks, darawk) and find the opposite: The people buying new guns are mostly (~80%) people who have guns already. This varies a bit by time period but other periods (the beginning of the pandemic and the 1/6 insurrection) were more disproportionately new gun owners than the June period when homicides started to spike. This also shows that the largest month-over-month increases in gun purchases, both new and total, were March 2020 and January 2021. There was no sudden homicide spike associated with either of these months, only May/June 2020. Finally, guns are usually more correlated with suicide deaths than with homicide deaths… State by state correlation between gun ownership and murder rates (left), and between gun ownership and suicide rates (right). Source here. …but there was no spike in suicides at the same time as the murder spike: Source This is what you’d expect given that the number of guns only increased by 2% over trend - a completely invisible effect on suicide. Unrelatedly, homicides rose by 30%. So the gun hypothesis requires that: Crime tracks the flow, rather than the stock, of guns.
Inline links: Wikipedia says, Miller, Zhang, and Azrael, darawk, https://substackcdn.com/image/fetch/$s_!alVC!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F3aee0f48-0747-4a30-80b3-297d79f4f7fc_710x504.png, https://substackcdn.com/image/fetch/$s_!TQUx!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2F5918467a-45dc-4e87-a2ab-230744fda597_1015x404.png, here, https://substackcdn.com/image/fetch/$s_!EJEG!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fbucketeer-e05bbc84-baa3-437e-9518-adb32be77984.s3.amazonaws.com%2Fpublic%2Fimages%2Fbb830b21-3151-4e54-9310-c3c29a0436bb_325x235.png, Source
Zhang Yiyi1 mentions across 1 issues

Zhang Yiyi is a recurring person in the Astral Codex Ten archive, appearing 1 times across 1 issues between October 30, 2025 and October 30, 2025. The archive places it in contexts such as "Chinese author and 'Shakespeare superfan' Zhang Yiyi spent $225,000 on plastic surgery". It most often appears alongside 767 AD, @Scientific_Bird, ACX.

Reference entry
Zhang Yiyi
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1
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1
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October 30, 2025
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October 30, 2025
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Links For October 2025
October 30, 2025 · Original source
24: Chinese author and “Shakespeare superfan” Zhang Yiyi spent $225,000 on plastic surgery to look like Shakespeare:
Inline links: spent $225,000 on plastic surgery to look like Shakespeare
Zhang Zongchang1 mentions across 1 issues

Zhang Zongchang is a recurring person in the Astral Codex Ten archive, appearing 1 times across 1 issues between January 17, 2025 and January 17, 2025. The archive places it in contexts such as "[Chinese warlord Zhang Zongchang]". It most often appears alongside @tamaybes, @venturetwins, A16Z.

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Zhang Zongchang
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1
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1
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January 17, 2025
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January 17, 2025
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Links For January 2025
January 17, 2025 · Original source
After seeing a basketball game for the first time, [Chinese warlord Zhang Zongchang] allegedly asked "Why the hell are they fighting over a single ball? We're the hosts. Are we seriously this poor?" He ordered all the players be given a basketball.
Zheng He1 mentions across 1 issues

Zheng He is a recurring person in the Astral Codex Ten archive, appearing 1 times across 1 issues between October 14, 2021 and October 14, 2021. The archive places it in contexts such as "Sick of the Columbus discourse? Why not try Zheng He discourse?". It most often appears alongside @literalbanana, ACX, Barcelona.

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Zheng He
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1
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1
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October 14, 2021
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October 14, 2021
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Links For October
October 14, 2021 · Original source
29: Sick of the Columbus discourse? Why not try Zheng He discourse? In particular, were his treasure ships really that much bigger than Western vessels of the time? Chinese and Western scholars argue that traditional estimates for the size of his ships are implausible, since wooden ships that big are not seaworthy. Most likely the ships he took on his expedition maxed out at around 200 - 250 ft, the same as the largest Western ships of the era.
Inline links: argue
Zheng-De1 mentions across 1 issues

Zheng-De is a recurring person in the Astral Codex Ten archive, appearing 1 times across 1 issues between August 19, 2022 and August 19, 2022. The archive places it in contexts such as "eng-Te (Zheng-De) had been a bad-ass rebel emperor". It most often appears alongside 1587, 1587, 1587, A Year of No Significance: The Ming Dynasty in Decline.

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Zheng-De
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1
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1
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August 19, 2022
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August 19, 2022
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Your Book Review: 1587, A Year Of No Significance
August 19, 2022 · Original source
If Wan-li ever considered standing up for himself and forcefully asserting his prerogatives, maybe even attempting to reform or at least improve the imperial government, he didn’t really have a lot of role models. His grand-uncle Cheng-Te (Zheng-De) had been a bad-ass rebel emperor, who certainly defied the bureaucracy and did as he pleased, but his legacy was presented to Wan-li as a cautionary tale:
Inline links: Cheng-Te
Zhong1 mentions across 1 issues

Zhong is a recurring person in the Astral Codex Ten archive, appearing 1 times across 1 issues between September 01, 2023 and September 01, 2023. The archive places it in contexts such as "zhong [the high minister in charge at the time] was ignoble in spirit". It most often appears alongside 536 BC, ACX, Ai Jiang.

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Zhong
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1
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1
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September 01, 2023
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September 01, 2023
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Your Book Review: Zuozhuan
September 01, 2023 · Original source
In autumn, in the seventh month, the Heaven-appointed king sent his steward Xuan to us to present the funeral equipment for Lord Hui and Zhong Zi.
Confucius said, “In three acts Zang Wenzhong [the high minister in charge at the time] was ignoble in spirit and in three acts was unwise. He kept Zhan Qin in a lowly position, he abolished the six customs barriers, and his concubines wove rush mats for sale. These are three ignoble acts. He fashioned meaningless vessels, he allowed a violation of the sacrificial order, and he sacrificed to the seabird Yuanju. These are the three unwise acts.”
The existing foundations of our world are damaged but not broken. For all the upheavals in recent years, I struggle to believe that the pace of change will slow, or that the ideas to truly make sense of these changes already exist. This is only the beginning, and the Zuozhuan gives a visceral sense of what that really means. Our culture wars will seem like people getting mad over ancestral tablet placements. People in the future will look at us the way we look at Ai Jiang weeping for her murdered sons, “Oh, Heaven! Xiangzhong violated the proper way. He killed the legitimate heir and established a secondary son.” There’s more than one layer of grief.
Zhong Zi1 mentions across 1 issues

Zhong Zi is a recurring person in the Astral Codex Ten archive, appearing 1 times across 1 issues between September 01, 2023 and September 01, 2023. The archive places it in contexts such as "funeral equipment for Lord Hui and Zhong Zi". It most often appears alongside 536 BC, ACX, Ai Jiang.

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Zhong Zi
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1
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1
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September 01, 2023
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September 01, 2023
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Your Book Review: Zuozhuan
September 01, 2023 · Original source
In autumn, in the seventh month, the Heaven-appointed king sent his steward Xuan to us to present the funeral equipment for Lord Hui and Zhong Zi.
Zhou Enlai1 mentions across 1 issues

Zhou Enlai is a recurring person in the Astral Codex Ten archive, appearing 1 times across 1 issues between April 14, 2022 and April 14, 2022. The archive places it in contexts such as "Zhou Enlai famously said of the effects of the French Revolution that it was “too early to say”". It most often appears alongside ACX, Adrian D’Souza, Aleph.

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Zhou Enlai
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1
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1
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April 14, 2022
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April 14, 2022
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Links For April
April 14, 2022 · Original source
19: Zhou Enlai famously said of the effects of the French Revolution that it was “too early to say”. But a diplomat who was there at the time says this wasn’t some kind of wise utterance about history - Zhou thought the question was about the French protests of 1968, which really were too recent to have an opinion on. (h/t Dylan Matthews)
Inline links: a diplomat who was there at the time
Zhu1 mentions across 1 issues

Zhu is a recurring person in the Astral Codex Ten archive, appearing 1 times across 1 issues between August 19, 2022 and August 19, 2022. The archive places it in contexts such as "His family name was ... Zhu (in Pinyin)". It most often appears alongside 1587, 1587, 1587, A Year of No Significance: The Ming Dynasty in Decline.

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Zhu
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1
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1
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August 19, 2022
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August 19, 2022
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Your Book Review: 1587, A Year Of No Significance
August 19, 2022 · Original source
No direct inline source block was recovered for this mention.
Zhu et al1 mentions across 1 issues

Zhu et al is a recurring person in the Astral Codex Ten archive, appearing 1 times across 1 issues between July 19, 2021 and July 19, 2021. The archive places it in contexts such as "In the two cases reported by Zhu et al". It most often appears alongside Adderall, alcohol, AMPA receptors.

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Zhu et al
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1
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1
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July 19, 2021
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July 19, 2021
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Peer Review Request: Ketamine
July 19, 2021 · Original source
Most of the work on clinical hepatoxicity has been done on chronic pain patients, who take very long ketamine infusions for complex regional pain syndrome. In the two cases reported by Zhu et al, liver injury began after 40-50 hours of continuous ketamine infusion, by which point patients had received 1000+ mg of ketamine. In the three cases reported by Noppers et al, liver enzymes were measured and found to be elevated after fifty hours, again after having received doses of ketamine in the 1000 mg + range.
Inline links: Zhu et al, Noppers et al
Zhu Rongji1 mentions across 1 issues

Zhu Rongji is a recurring person in the Astral Codex Ten archive, appearing 1 times across 1 issues between April 13, 2022 and April 13, 2022. The archive places it in contexts such as "Premier Zhu Rongji". It most often appears alongside 16th Central Committee, Alaska, Aristotle.

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Zhu Rongji
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1
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1
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April 13, 2022
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April 13, 2022
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Biography of Jason Shea, 44th US President
April 13, 2022 · Original source
In Fujian, Xi made efforts to attract investment from Taiwan and to strengthen the private sector of the provincial economy. In February 2000, he and then-provincial Party Secretary Chen Mingyi were called before the top members of Central Politburo Standing Committee of the CCP – General Secretary Jiang Zemin, Premier Zhu Rongji, Vice-President Hu Jintao and Discipline Inspection Secretary Wei Jianxing – to explain aspects of the Yuanhua scandal. In 2002, Xi left Fujian and took up leading political positions in neighbouring Zhejiang. He eventually took over as provincial Party Committee Secretary after several months as acting governor, occupying a top provincial office for the first time in his career. In 2002, he was elected a full member of the 16th Central Committee, marking his ascension to the national stage.
Zhu Yifu1 mentions across 1 issues

Zhu Yifu is a recurring person in the Astral Codex Ten archive, appearing 1 times across 1 issues between September 01, 2023 and September 01, 2023. The archive places it in contexts such as "In the third month, our lord and Zhu Yifu swore a covenant at Mie"; "Who is Zhu Yifu?". It most often appears alongside 536 BC, ACX, Ai Jiang.

Reference entry
Zhu Yifu
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1
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1
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September 01, 2023
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September 01, 2023
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Your Book Review: Zuozhuan
September 01, 2023 · Original source
In the third month, our lord and Zhu Yifu swore a covenant at Mie.
Who is Zhu Yifu? Who’s Duan? What’s all this about “overcoming”? Where does the moral deliberation come in? This canon badly needs meta, and the most notable of the ancient commentaries written for the Spring and Autumn Annals is the Zuozhuan. Ten times as long as the text it’s for, the Zuozhuan is the flesh on the Annals’ bare bones, one of the foundational works of ancient Chinese literature and history-writing in its own right.
Zhuangzi1 mentions across 1 issues

Zhuangzi is a recurring person in the Astral Codex Ten archive, appearing 1 times across 1 issues between September 01, 2023 and September 01, 2023. The archive places it in contexts such as "Zhuangzi would snark about dressing a monkey up". It most often appears alongside 536 BC, ACX, Ai Jiang.

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Zhuangzi
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1
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1
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September 01, 2023
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September 01, 2023
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Your Book Review: Zuozhuan
September 01, 2023 · Original source
Chinese philosophers from just a century or two later would think this was ludicrous. Zhuangzi would snark about dressing a monkey up in the robes of the first regent Duke of Zhou—it would only bite and tear the robes off. The world had changed; the golden age was forever gone, even if you aped its trappings. Lord Shang, the Legalist reformer, might’ve been the first to go deeper, theorizing that the pressures of growing population create new problems and require the development of new forms of governance. Certainly, with the ideas we have today, it’s clear that the golden age was completely unsustainable to begin with.
Zick & Bryant1 mentions across 1 issues

Zick & Bryant is a recurring person in the Astral Codex Ten archive, appearing 1 times across 1 issues between May 15, 2025 and May 15, 2025. The archive places it in contexts such as "Zick & Bryant point out that a large portion of childcare time is 'secondary childcare'". It most often appears alongside ACX survey, Amazon, Barbara Kingsolver.

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Zick & Bryant
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1
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1
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May 15, 2025
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May 15, 2025
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Book Review: Selfish Reasons To Have More Kids
May 15, 2025 · Original source
...some people put their kids in daycare? Even at age nine, W&C say both parents are spending a combined 9 hours per day, every day! Why are these two sources so different? Zick & Bryant point out that a large portion of childcare time is “secondary childcare” while doing something else. This could be anything from “you’re sneaking a peek at your phone i...
Zigas1 mentions across 1 issues

Zigas is a recurring person in the Astral Codex Ten archive, appearing 1 times across 1 issues between July 12, 2024 and July 12, 2024. The archive places it in contexts such as "That evening Apekono asked Zigas not to try to cure any more kuru victims"; "and Zigas, I dunno, the book neglects him a bit here"; "Zigas as an “actual doctor”". It most often appears alongside 1980s, 1989, 1990s.

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Zigas
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1
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1
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July 12, 2024
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July 12, 2024
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Your Book Review: The Family That Couldn’t Sleep
July 12, 2024 · Original source
(This report was, as it happens, published in the exact same month as The Family That Couldn’t Sleep.) DTM came to know the family well. He befriended them by way of two members of their younger generation, Lisi – a woman terrified by the shadow of the disease, and Ignazio – the doctor she had married, who was more terrified by the shadow of the disease. Ignazio put together the pieces of the family puzzle, consolidating all the disparate diagnoses into a single disorder and filling out a lot of blank spots on family trees. When DTM came along, he was able to help Ignazio make the case that the family would benefit from the spotlight – that greater awareness of FFI could lead to a cure both for them and for a slew of other prion diseases. As it so happens, he is one of those nonfiction authors who serve as a character in their own story. DTM has some form of progressive muscular palsy. He is, or at least was in 2006, not entirely sure what it is. The relatively unimpressive state of genetics at the time had not identified his causative mutation, though it looked a lot like one of the rarer forms of Charcot-Marie-Tooth disease2. DTM is pragmatic about this, the way everyone chronically ill is either pragmatic or doomed. Whatever he has, it is a defect in protein structure; his peripheral nerves decay not because of a problem with the nerves themselves but an inability of their scaffolding to hold them together, as he puts it. The last chapter of the book dwells on this, on the web of connections popping up between a thousand disorders. DTM’s disease is something vaguely similar, if you squint, to an exceptionally slow-progressing motor neurone disease; if you jump another level out, you see amyloid plaque diseases like Huntington’s and Alzheimer’s, and if you jump yet another level out, you see something like prions. His interest in the Venetian family was driven by this. Some of its members thought this a beautiful act of sympathy; others thought him a grotesque parody of themselves, an onlooker, a gawker, peddling their tragedy to salve his relatively insignificant problems. They are, he thinks, both right. That’s the beginning, and that’s the end. What happens in the middle? --------------------------------------------------------- The Venetian family lends the book its title, but they’re really more of a framing device. The Family That Couldn’t Sleep is separated into four parts, of which the first and fourth – the shortest by far – deal with the family. Part 2 is kuru, the king of fucked up diseases you read about in clickbait Weird Medicine listicles. Let’s talk about kuru! Kuru, is, famously, the prion disease you get if you eat another person’s brain. Well, not quite. It’s a prion disease that became endemic amongst women in the Fore society, who ritually ate brains, one of which had an inherited or spontaneous prion disease. This is an important note – there’s a tendency (which the book’s later chapters engage in) to assume cannibalism just has a Prion Disease Generator attached. If you eat people who don’t have prion diseases, you won’t suddenly get one. Uh, don’t eat people. Anyway, part 2 is DTM’s historiography of Fore-Westerner first contact. It’s hilarious. Papua New Guinea is a frankly ridiculous place; one of the all-time best Lyttle Lytton winners (worst first sentence from a hypothetical or, in this case, real work) was “Papua New Guinea is so violent that more than 820 languages are spoken there”. The native residents were so hostile to outsiders that all the colonial empires had cut their losses – and when you think about the places they colonized, that says something. After the First World War, PNG was ripped from its nominal German ‘owners’, but no one else wanted the place. So, of course, they gave it to the Australians. It was thirty years and another war before we actually made contact. 1940s Australia was as ‘settled’ as it’d ever be; the cities were bustling and the interior was mapped. The kind of explorer who two centuries before would be heading to new continents had to console himself with Pacific islands. Console he did. The native peoples of the PNG coasts were hostile enough to the wannabe-colonialists that the Australians, flying planes overhead, were the first people to discover that the island’s inland was populated too. No one had broken through on land. In all this deep and angry rainforest, the Fore were the furthest out. They lived far into the island’s mountainous interior; DTM describes their territory as “nearly vertical”. Calling people primitives is a bit passe these days for understandable reasons, but no other term comes to mind. The Fore had no name for themselves; we call them by an exonym, “the people to the south”. They weren’t, to be clear, hunter-gatherers – they were slash-and-burn agriculturalists, but very well-fed ones. Despite the tendency in grain-focused cultures for poor agriculturalists to be stunted/malnourished, the Fore were a remarkably healthy people. Well, except for the famous bit. The first remarkable thing about the Fore was just how quickly they wanted to assimilate. Most PNG tribes weren’t particularly enthused by Western offers of injections/tractors/radios/Christianity. Yet as soon as the Australians arrived, the Fore made ceasefires in their wars with other tribes, volunteered to help large-scale Australian projects on the coast, started planting and trading coffee, and enthusiastically participated in censuses. It’s the only first-contact narrative I’ve seen where the colonizers were concerned about how badly the other guys wanted to be colonized. The next was the one that got their names in the history books. Australian officials started to notice a remarkable lack of women in Fore camps. Some tribes sequestered their women, particularly when Westerners were around, so at first they thought nothing of it. The high rate of unpartnered young men, though, was way out of PNG norms. DTM tells this part fantastically. The Fore chapters drip with the dread of dramatic irony. When the first breakthrough comes, you have to catch your breath: “Tiny” Carey noted something in the middle of August 1950 that deepened this mystery. He noticed that near the village of Henganofi there had been an unusual number of deaths. “It appears,” he wrote his superiors, “natives suffer from stomach trouble, get violent shivering, as with the ague, and die fairly rapidly.” [...] McArthur investigated a little more [...] One day in August 1953 he ran into more of the shivering people Tiny Carey had seen several years before: “Nearing one of the dwellings, I observed a small girl sitting down beside a fire. She was shivering violently and her head was jerking spasmodically from side to side.” It would be quite some time before anyone figured out what caused it – but the problem, as DTM notes, was that its cause wasn’t possible. Everyone priored that the weird undescribed disease in the Fore lands was some nocebo sorcery-sickness. Vincent Zigas, the first actual doctor sent to work with the Fore, tried to placebo-effect them and failed miserably: On the way, Apekono stopped at a hut and showed Zigas his first kuru victim. “On the ground in the far corner sat a woman of about thirty,” the doctor wrote. “She looked odd, not ill, rather emaciated, looking up with blank eyes with a mask-like expression. There was an occasional fine tremor of her head and trunk, as if she were shivering from cold, though the day was very warm.” It was almost exactly the tableau McArthur had witnessed in 1953. Zigas, though, was a doctor. He could do more than look—or so he thought: “I decided I might as well try my own variety of magic,” he remembered. He rubbed Sloan’s Liniment, a balm for sore muscles, on her and declared to her family and his guide: “The sorcerer has put a bad spirit inside the woman. I am going to burn this spirit so that it comes out of her and leaves her. You will not see the fire, but she will feel it. The bad spirit will leave her and she will not die.” The lotion penetrated the woman’s skin and she writhed in pain. “Get up! Walk!” Zigas commanded theatrically. “The woman struggled feebly as if to rise, then, exhausted, started to tremble more violently, making a sound of foolish laughter, akin to a titter.” That evening Apekono asked Zigas not to try to cure any more kuru victims; “Don’t use your magic medicine anymore. It will not win our strong sorcery.” This was a disaster. The Fore were so cooperative precisely because they hoped “Western magic” could conquer theirs. As it became clear it couldn’t, they turned hostile. The Australians had hoped to “modernize a Stone Age people”; now all their subjects were dropping dead before their eyes, from what they could only assume was a “hysterical reaction” to colonization itself. So, to solve this, they needed a batshit insane American. Carleton Gajdusek is one of the characters who dominates The Family That Couldn’t Sleep. He couldn’t not. You could put him in a car commercial and he’d dominate it. Gajdusek was a physician with a rare, intense combination of science and practice. He was a romanticist, a field worker, and a lover of everything strange. He’d been an army doctor, a government conspiracy-cover-upper, and a postdoc under Linus Pauling who described his intent as “to straighten out Pauling’s ideas about proteins”. He hated civilization, in a slightly-to-Ted’s-centre sense, and was passionate about “primitives and isolates”. He jumped at the chance to work in Papua New Guinea; he planned to conduct a multi-site study on child development in such cultures, and relished the opportunity to live in a “primitive” environment himself. He did all this so he could rape kids. Oh, he did it for the scientific curiosity and love of medicine, but he also did it so he could rape kids. Gajdusek was a pedophile in the actual-lifelong-exclusive-paraphilia sense, as opposed to the “metonym for child molester” sense. Some people who roll snake-eyes on the Sexuality Dice repress it, but some are perfectly happy to act on it; Gajdusek was #2 in its fullest form, the kind of guy who believes that a well-lived life includes raping some kids. DTM doesn’t shy from this, not for a moment. It’s the first thing he tells you about Gajdusek. It couldn’t not be; you couldn’t talk about why he went to PNG otherwise. When Gajdusek landed in PNG, he first found the place too civilized. He’d been promised a land of “cannibal savages” – where were they? After some traipsing, he found them, right where he was promised. The Fore were perfect for Gajdusek. They had some kind of medical mystery that’d been lost on everyone else. They ate each other, in exactly the way he loved detailing in his diaries (“”Women and children, particularly, partake of the human flesh,” he noted with pleasure”). As kuru cases popped up, he aggressively recorded them. He wrote lovingly detailed notes that he sent back to his Australian advisor. He wrote with intensity, with exclamation marks, with the joie de vivre of a man just where he wanted to be. Gajdusek smothered the Fore with ‘cures’ that never worked, but they didn’t get angry at him. As DTM dryly puts it: “Their children trusted him, and that was enough for them.” At some point, someone suggested sending an anthropologist...or an epidemiologist...or literally anyone with more credentials than Gajdusek and Zigas3. Gajdusek threw a shitfit, convinced this one-and-a-half-man team was enough to Solve The Problem Forever. But he got bored eventually – running off with another tribe with, as his diary notes at length, an apparent custom of youths ritually fellating older men – and Zigas, I dunno, the book neglects him a bit here. So they managed to sneak in some anthropologists. The husband-and-wife team of Robert Glasse and Shirley Lindenbaum4 were the first involved parties to give a shit about the Fore as people, rather than as colonial subjects/medical mysteries/walking sex toys. What they uncovered was fascinating. The Fore were cannibals, yes, but they were recent cannibals. They didn’t have an ancient tradition of eating their dead, like the other visitors assumed. They happened to be in contact with some cannibal groups, and after a Fore man died of “sorcery”, they thought: well, what would happen if we ate him? “People tasting it expressed their approval. ‘”This is sweet,” they said, “What is the matter with us, are we mad? Here is good food and we have neglected to eat it.”” If not for the wild coincidence that the first Fore cannibalism victim had a prion disease, kuru would never have existed. Glasse and Lindenbaum started to put together the pieces. They’d been sent down to rule out a genetic explanation – to track the kinship ties of the Fore and see how the disease ran through families. It didn’t run through families in any coherent sense, but it sure did run through cannibalism. The clincher was the age distribution. The Fore, ever enthused by colonialism, quit eating each other as soon as the Australians arrived. Children stopped dying of kuru shortly after; they simply weren’t exposed to the infectious agent. The couple sent the news to Gajdusek, who was off raping kids somewhere else. In the next part of the book, DTM runs through Gajdusek’s many conjectures of kuru’s cause – more like sketches or abstract paintings than like true hypotheses. Gajdusek was annoyed that someone else was doing something he “totally could’ve done”, and even more annoyed that another lab was running similar experiments – an attempt at a vaccine for a particular sheep disease had accidentally created a prion generator. But he was happy to swoop in and claim the credit for what he was starting to think of as “slow viruses”, an infection that somehow lays dormant for years. DTM portrays Gajdusek perfectly, in that “real life has no need for verisimilitude” way. Gajdusek was at once a brilliant man, an all-consuming narcissist, an entertaining character, and a monster beyond redemption. A lesser book might pick one or two. The Family That Couldn’t Sleep portrays him as all four, and on a personality level (as opposed to a scientific one), the Gajdusek-focused parts are some of the most gripping. --------------------------------------------------------- Outside of the jumps between the Venetian family and everything else, The Family That Couldn’t Sleep is not siloed. The narratives of all prion diseases are deeply intertwined. This is what makes it a great book. It’s 300 pages of dramatic irony. You read the whole thing, waiting for the eureka moment – the point everyone realizes they’re looking at the same cause. It does, however, make it a tad difficult to review or synopsize. The book’s story is so weird – and, often, so at odds with conventional wisdom that trickles down about the Fore et al – that you have to recap quite a bit, and the book steadfastly resists recapping. The next couple chapters after we depart from Gajdusek’s credit-claiming are mostly about experiments with various prion diseases. They’re scientifically fascinating. Unlike some medical-books-for-general-audiences (cough, How Not to Study a Disease), DTM never talks down to the reader. He assumes someone reading a 300-page book about prions is smart and wants to learn about prions. He also has – you can feel it in his words – the agonizing experience of spending his life on the other side of the doctor’s desk, trying to beat into whoever he’s talking to that no, seriously, you don’t need to lie to him or try explain a complex disease at a fourth-grade level. The first prion disease studied was scrapie. Scrapie was a big deal – it starved and killed large shares of British sheep flocks, making it a serious economic problem. Veterinary researchers had tried to prevent or cure it for centuries. It was a veritable graveyard of ambitions: Quintessential was D. R. Wilson at the Moredun Institute in Scotland, who worked in the middle of the last century for more than a decade trying, with mounting frustration, to kill the scrapie agent. He found that it survived desiccation; dosing with chloroform, phenol, and formalin; ultraviolet light; and cooking at 100 degrees centigrade for thirty minutes. The scrapie researcher Alan Dickinson told me he remembered Wilson at the end of his career as “very, very, very quiet. Of course, that was after his breakdown.” “Now it is our turn to study prions. Perhaps we should approach the subject cautiously.” The problem, as DTM explains, is that prion diseases were impossible. They violated 20th-century understandings of biology. Proteins “were no more alive, and no more infectious, than bone”. Prion diseases seemed to have too many causes – genetic, infectious, and sporadic. They looked infection-like in some ways, but patients didn’t produce virus antibodies. Sheep exposed to scrapie, or chimps infected with kuru, took years to develop symptoms. Their facts did not fit together. In the 1960s, people started wondering. The unifying trait of prion agents was that they had to be denatured to be destroyed. Was this a particularly small virus defined by its protein coating? Or – even more outre – was it pure protein, no DNA at all? No one could figure out quite how the latter worked, but it was tempting. Gajdusek, by now a major figure in this field, kept a foot in both worlds. He didn’t want to stake his reputation on a no-DNA hypothesis, but he certainly sympathized. Enter Prusiner. Stanley Prusiner was Gajdusek’s counterpart. Where Gajdusek seemed permanently manic, Prusiner was deliberate and exacting. He entered Gajdusek’s “slow viruses” field in the early 1970s after a chance encounter with a CJD patient. He relished the laboratory in a way Gajdusek didn’t at all, and set out to optimize the hell out of his projects. Prusiner set out to isolate the smallest infectious particle in the scrapie agent. He injected tons of hamsters (hamsters got sick faster than mice) with increasingly tiny scrapie proteins, hoping to determine whether the Minimum Viable Scrapie was DNA. By the mid-1980s, he’d produced something so small it couldn’t possibly be a virus. Denaturing it destroyed it; exposing it to nucleic acid dissolvers actually made it stronger. Emboldened by this discovery, Prusiner set out to anoint himself the King of Prions. Here emerges something of a Voldemort-Umbridge distinction – the difference between cartoonish villainy and banal evil. Gajdusek is a bad guy because he rapes kids. Prusiner is a bad guy because he is the most grotesque stereotype of the Advisor/Peer Reviewer from Hell made flesh. Everything Prusiner did was to build his reputation atop a pile of skulls. When recruited as a peer reviewer for other prion papers, he wrote negative reviews to undermine their authors. He worked his grad students to the bone and intentionally destroyed their careers, telling them he’d “ruin them” if they entered prion research as competitors. He lied about the origin of the protein-only hypothesis, claiming he originated it a decade after it was actually conjectured. But hey, he was good at getting grants. I was surprised reading a lot of this, because for all the time I’ve been aware of it, the cause of prion disease has seemed settled. “Oh yeah, it’s a protein that gets all fucked up.” But DTM goes through just how unsettled it was right up through to The Family That Couldn’t Sleep’s publication. Serious confirmation only arrived a couple years later. Many people were deeply critical of the prion hypothesis – often, it seemed, because they loathed Prusiner too much to go along. Throughout the book, he cuts an uncharismatic figure. Gajdusek and Prusiner both won the Nobel for discovering prions, decades apart. This tells you something – the “discovery” of prions can be construed quite a few ways. Gajdusek formulated the hypothesis; Prusiner proved it. Gajdusek was grievously offended by Prusiner’s Nobel, perceiving his rival – not inaccurately – as a follower who never originated any ideas of his own. But Gajdusek was offended from a federal prison cell, so how’d that work out for him? Fascinating as all this is, no one published a book about prions in the mid-2000s because it was about kuru or FFI. They published books about prions because teenagers were dying, and people wanted to know why. DTM lays the seeds for part 3 – the mad cow section – in part 1. This is a discussion of scrapie, the longstanding prion disease of sheep. Scrapie was a medical mystery for centuries (remember poor D. R. Wilson), precisely because of the intuitive implausibility of prions. The scrapie chapter is a great history-of-science piece, covering the agricultural productivity revolutions of the 18th century, the surfeit of bizarre origins veterinarians concocted, and the treatments that never worked. Scrapie is not transmissible to humans – well, we hope. It’s concerningly transmissible to primates. But it’s been around for a long, long time, and it doesn’t epidemiologically look like humans get it...we hope. Anyway, you ever tried to generalize from one example? The British government did! In the mid-1980s, strange reports started coming out of the UK’s farms. Farmers were describing a new disease where dairy cows – incredibly docile creatures, under normal circumstances – turned hostile, kicking them as they went into the milking stalls. The symptoms looked to all the world like scrapie. Epidemiologists tracing the outbreaks found a unifying link with “cake” – animal protein feed sweetened with molasses. The scrapie-like symptoms must have traced to an infected sheep. But scrapie doesn’t transmit to humans, so it must be okay to keep slaughtering them, right? We all know how this ended. The best term for the British response to the mad cow outbreak is “cacklingly evil conspiracy”. The agricultural industry really, really didn’t need a huge zoonotic outbreak – so it decided it didn’t have one. They first suppressed all mentions that the disease looked like scrapie, then – when this became impossible – hyped up that scrapie doesn’t transmit to humans, so there’s nothing to worry about. The formal name of the disease, “bovine spongiform encephalopathy”, was supposedly chosen to optimize for unfamiliarity – it wouldn’t fit well in a headline. They emphasized, extensively, that there was nothing to worry about. Ever. At some point, people started asking questions. If there was nothing to worry about, why was the agricultural industry panicking so hard? As things became ever more worry-inducing, this turned down ludicrously twisting paths: Meanwhile, the Southwood Working Party and the experts who advised it were learning on the job. They learned, for instance, that the BSE agent entered the animal through the mouth and then followed the digestive tract into the organs that try to filter out infections—the tonsils, the guts, and the spleen—and from there traveled into the peripheral and central nervous system, and finally arrived at the brain. They also learned that pasties, meat pies, and even some baby foods contained tissues from a lot of those organs. So the Southwood Working Party recommended banning these organs, but only from baby food. This started a chain reaction of consumer doubt: if infected cow organs were unsafe for babies, how could they be good for adults? The government then banned offal, as the organs were collectively called, in all human food but gave the industry a grace period to get it out of the feed supply. Then pet food manufacturers began to wonder if what drove cows mad might not also drive dogs, cats, and parrots mad. The feed they sold came from concentrate made of the same sick animals that had previously made up the meat and bone meal farmers used. Their trade group decided to put a similar ban in place—immediately. So for five months it was safer to be a dog than a human in Britain. DTM spends pretty much this whole section of the book making fun of the British government. To be fair, they deserved it. They killed hundreds of kids in agonizing and preventable ways – they could take some ribbing. This is all throughout the mid-1980s to early-mid 1990s. Through this period, it wasn’t yet clear that mad cow could spread to humans. The panic was clear, and deserved, but it didn’t yet have a match for its powder keg. It would alight. The first suspected case of vCJD – human mad cow – was in 1994. Fifteen-year-old Vicky Rimmer developed a sudden, strange disease. Doctors gave her months to live...until she died in 1998. A couple other suspected cases trickled down through the mid-90s, including a young man who made meat pies for a living, whose grieving mother received a letter from the Prime Minister that “humans do NOT get mad cow disease”. (That must’ve been fun.) Soon, they couldn’t deny it any longer. On March 20, 1996, Stephen Dorrell, the health secretary, stood up in Parliament to announce the news that had already appeared as a tentative conclusion in scientific journals and as rumor in newspapers for the previous two years: British beef was killing British teenagers. The first confirmed death was that of Stephen Churchill, a nineteen-year-old student from Wiltshire, who died in May 1995. Back in 1989, at the Southwood Working Party’s suggestion, the government had set up a surveillance unit in Edinburgh to watch for any evidence that BSE had crossed to humans. One worry had been that if BSE passed to humans, how would anyone know it? How would you recognize something you had never seen? It turned out to be easy: Churchill and the nine other teenagers who had gotten sick had spectacular amyloid plaques in their brains, chunks of dead protein almost visible to the naked eye. If sporadic CJD was a whisper, BSE-caused prion disease was a shout. The investigators sat open-mouthed looking at slides whose damage, they feared, portended the most severe epidemic in modern British history. This part of the book is not fun. It lacks the insane personalities and duelling careers of the other entries. It is an honest chronology of the vCJD epidemic – a gruesome failure of the agricultural industry, the one system that everyone is vulnerable to. The government and industry had completely violated their duty of care to citizens and consumers. They were paying the price. No one would buy British beef anymore – not while they watched their children die. Now here’s the thing: this is ethnography, not historiography. The Family That Couldn’t Sleep is a book from the mid-2000s. The epidemic was not at all in the rear view mirror. There were piles of unanswered questions that DTM constantly alludes to. We have eighteen years more hindsight than he did then. What do we know now? --------------------------------------------------------- In 2006, the vCJD epidemic looked like it was going to be a lot better than the worst fears. BSE itself was a huge problem for the cattle industry, but honestly, no one is too sympathetic to the cattle industry. People were not going to die in anywhere near the numbers believed. We had all sorts of reassuring data coming out about this, which DTM chronicles. We were learning that only some genotypes seemed susceptible to vCJD. We didn’t see any older people die of the disease. We were seeing numbers drop, such that vCJD must have a pretty short incubation period. Anyway, all of this is wrong! The Family That Couldn’t Sleep was written in the candidate gene era. Back then, the nascent field of human genetics was sure it was about to Solve Polygenism. Yes, the simple Mendelian monogenic patterns popular a few decades back clearly didn’t apply to common diseases, but how many variants could there be? We were about to discover the five genes influencing 20% of Alzheimer’s risk each, the five genes influencing 20% of heart disease risk each, etc., and once we were done we’d just do gene therapy and cure Alzheimer’s. A paper on autism genetics from 1999 was so outre as to speculate there might be as many as fifteen genes involved. The fact we are now using the term “omnigenic model” should tell you roughly how well this worked out. Do you remember SNPedia? If you were a 2014 Slate Star Codex reader, you might. 2014 was still pretty candidate gene. People were out there publishing papers saying a single variant could increase your life expectancy by 15 years. SNPedia was a site that beautifully categorized all of these, so you could do 23andme or whatever, look up your results on SNPedia, and make horrible life choices.5 It was eventually bought out by one of the consumer DNA companies, so no one ever edited it again, making it a great time capsule of early-mid 2010s behavioural/medical genetics takes. SNPedia will excitedly explain to you that common genetic variants make you immune to vCJD. They cite a 2009 post from the now-archived 23andme blog titled “No Good Evidence That Potential Pool of Mad Cow Disease Victims Is Expanding”, explaining how fears of late-onset vCJD are clearly debunked by new Scientific Knowledge. Everyone who developed vCJD in the 1990s and 2000s had an M/M genotype in a particular part of the PRNP prion gene, so the roughly half the population with M/V or V/V genotypes were immune. The Family That Couldn’t Sleep buys this, too. In fact, it buys it in an even more agonizingly 2000s way. The first sign that transmissible prion diseases weren’t genotype-restricted should’ve been the growth hormone kids. You might have heard this story – from the late 1950s through mid-1980s, human growth hormone produced from brain tissue was used as a treatment for pituitary dwarfism, until it turned out to spread CJD if the originating brain was infected. DTM discusses this, to set the scene for the genetics thing. He mentions what was the state of the art at the time – that a disproportionate share of both the growth hormone kids and sporadic CJD cases were V/V homozygotes. This, uh – so the book was written in the mid-2000s, yeah? Yeah. The conclusion DTM drew – and this was a common conclusion at the time – was that homozygosity somehow made you more vulnerable to CJD, and M/M homozygosity made you vulnerable to BSE-borne CJD in particular. We cannot criticise the author for not predicting the future, but we live in the future, and can say how this worked out. Turns out, nope, M/V heterozygotes totally get vCJD. After a British man in his 30s died of CJD in 2016, he was found to have vCJD and an M/V genotype. He was tested for vCJD only because he was exceptionally young for someone with a sporadic prion disease – meaning people developing it later in life would be missed6. Did you know up to 1 in 2000 people in the UK have latent vCJD? There is one line in The Family That Couldn’t Sleep that stopped me dead in my tracks when I read it: What happens to the Italian family in the end depends less on their own actions than on the world’s interest in prion diseases, which they cannot control. If lots of people are afraid of getting variant CJD, the family benefits. If fear of prion disease goes the way of the fear of swine flu or Ebola, then they will be orphaned again. THIS BOOK IS FROM 2006! Three years before the swine flu pandemic! Eight years before the Ebola pandemic! “If you’re looking for a sign, this is it.” --------------------------------------------------------- The last section of The Family That Couldn’t Sleep addresses BSE fears in America and a nascent internet subculture DTM calls “Creutzfeldt Jakobins” – people who track American CJD cases, trying to spot vCJD patterns. When reading his description of the Creutzfeldt Jakobins, my mind constantly, uncontrollably turned to covid. Here it was – an online community of people deeply skeptical about a disease’s official story, tracking every contradiction, every implausibility, every statistic that failed to apply to the individual. Self-described “redneck hippies” and “soccer mom Republicans” teaming up to find the truth hidden behind an impossible world. You know what they’re doing now. I’ve always combined a deep interest in medicine with a healthy distrust for it. People who are constitutionally inquisitive, anti-authoritarian, and suspicious about official narratives tend to end up skeptical of at least some mainstream claims in the field. This is not to say I think you should take bleach enemas or something, just that I understand the impulse behind concluding the US government was covering up a local vCJD wave. Traditionally, sporadic prion diseases are said to have a prevalence of one in a million. (Hold on to that for a second.) The last section of the book is a chronology of Americans finding bizarrely more than one in a million of their friends dying of sporadic CJD, often at inexplicably young ages, sometimes in geographical clusters. This is understandably suspicious. Then DTM goes on to reassure us by saying none of these cases were confirmed to have an M/M genotype, which OH GOD OH FUCK A number of high-profile people in the prion world, including Gajdusek, are clarified as not believing sporadic prion diseases exist. You get the impression DTM doesn’t, either. Now, how common are prion diseases? Eric Vallabh Minikel has an answer for you! Eric and his wife Sonia are prion researchers from a rather unique background – after Sonia was diagnosed as having a single-gene mutation with ~100% penetrance for prion disease, they left their previous jobs to dedicate their lives to curing it. It turns out, when you run the numbers, you get not one in a million but 1 in 5000 people dying of prion diseases. This is best described as “nightmarishly high”. I’m normed on genetic disorders. A genetic disorder that affects one in five thousand people is pretty common! I have known, in person, completely unselected, just from “random people I’ve met in my life in a non-medical context”, someone with a ~1/250k syndrome and someone with a ~1/50k-100k syndrome. I don’t think anyone in my extended family knows someone who died of a prion disease. I feel like it would’ve come up if they did! Prion diseases have distinctive phenotypes. Not distinctive enough, apparently, to avoid a lot of CJD being misdiagnosed as Alzheimer’s – but diagnosis is consistently insane. Something DTM reiterates throughout The Family That Couldn’t Sleep is just what prion dementia looks like. The characteristic dementia in prion diseases spares something – “self” or “recognition” or “reflection” – that is not spared by Alzheimer’s, or by most common dementias. Shouldn’t this be, uh, noticeable?7 They kill rapidly, often over the course of months, and often onset in midlife. ALS shares this pattern and is way, way more common than prion diseases; you hear about ALS far more in the “disorder people actually have” sense. What am I missing here? Anyway: 1 in 2000 prevalence of latent vCJD in the UK + extreme lack of clarity over whether scrapie is human-transmissible + blood donations spread vCJD + sporadic CJD prevalence keeps going up = ??? (Yes, I am annoyed that most countries have lifted their ban on UK blood donors, thank you for asking!) --------------------------------------------------------- But back to the book. The “American chapter” is one-third about the country’s response to vCJD, one-third about the Creutzfeldt Jakobins, and one-third about chronic wasting disease. The last part is the most interesting. Chronic wasting disease is a prion disease of deer. Like scrapie, it “probably, we hope” isn’t human-transmissible (eat venison at your own risk). Under natural circumstances, deer shouldn’t get prion diseases: A prion plague should not be possible among ruminants in the wild. Deer are not cannibals, as the cows that spread BSE were forced to be; and, because deer and elk are not domesticated, they do not have enough contact with one another to spread a prion infection the way sheep are thought to spread scrapie. But deer do not live as they used to live, humans having once again brought their ambitions to bear on the natural course of things. The Family That Couldn’t Sleep is a book of medical anthropology. Anthropology of the Veneto, anthropology of Papua New Guinea, anthropology of 1990s Britain. Here, it is an anthropology of America. Americans, having won the world, still fight to win their own backyard. The North American continent is geographically diverse, cutting through rain-snow-shine, mountains jutting over plains, cities sprawling into wilderness, habitations criss-cross dotted with surprisingly few empty zones. Go somewhere like Denver, the Mile High City, three million people fighting against nature. Few other countries have anything like this; geographically vast polities usually have uninhabitable blocks. Australians are twenty-five million people clustered against the shore. It still surprises me, after all this time, how every US state has a meaningful city8. Midcentury Denver, growing and sprawling out across its mountains, started to run into their natural inhabitants – deer. Starvation is one way nature adjusts the deer population to the available food supply. People did not usually see this process, but in the 1950s and 1960s Colorado became more densely settled, reducing forested areas and forcing deer to look longer and harder for food. At the same time, the state enacted conservation laws, limiting when and where hunters could shoot. Soon emaciated deer began wandering onto the lawns and through suburban streets looking for a meal. People began to feed them, only to find that they died anyway. They would drop dead by haystacks, along highways, and in flower beds. In the late 1960s, a young biologist named Gene Schoonveld tried to figure out why the deer starved even when they were fed.9 He deprived some deer of food for a while, “[h]e cut windows in their stomachs to see what went on inside, and then he began to feed them”. While this was going on, he had a control group of healthy, well-fed deer as backups in case anything went wrong. It did...but not to the experimental group. The pen in which the deer were kept also housed sheep, which, it turned out, were scrapie carriers. The deer somehow acquired scrapie – there’s a huge unanswered question here, which DTM doesn’t address. How did they get scrapie? They didn’t eat the sheep, presumably. Did it somehow transmit from casual contact? This is not supposed to happen. And yet: the deer in the sheep pen started dying of a mysterious scrapie-like disease, one never reported before, that would go on to infect thousands. These deer were released into the wild. Ten years later, the first reports of chronic wasting disease came out. The disease spread across deer and elk in the western half of the country. By the turn of the millennium, cases were exploding – and lost all geographical restriction. DTM can report up to 2005, at which point it was floating around Upstate New York. This kind of spread doesn’t track natural deer migration. That’s irrelevant, because nothing about CWD’s spread is natural. We shift gears into an anthropology of the American hunter. The hunter wants to shoot the most impressive buck, to bag himself one with as many “points” as possible – one whose antlers branch out most. A “ten-point buck” has five branches on each horn: Original by Ric McArthur Nature doesn’t make enough bucks with perfectly symmetrical ten-point horns. To fill the demand, the market had to step in. Thus was born the deer farm industry, which raises captive deer in better genetic and nutritional conditions than Nature permits, then ships them across the country so hunters who couldn’t get legit ten-point bucks get the taxidermy piece for their wall. These are controversial amongst hunters and illegal in numerous states – but the industry is big enough to spread CWD. (The kind of hunter who needs a deer shipped to his house is the kind of hunter who will fumble killing it.) Another problem is supplemental feeding – leaving out protein-enriched food for deer to eat. This produces “trophy class animals at an earlier age”, but again, what’s in that protein? (“It is much like feeding your cows 41 percent protein cottonseed cake during the winter to raise the protein level in the cow’s diet to a level that will maintain acceptable production”, says that article from 1991.)10 The book segues into a vignette. CWD was new in Wisconsin in the early 2000s, and the state’s Department of Natural Resources was optimistic it could eradicate it. In a state with a love of hunting, you could, in theory, recruit people to kill every single deer in a 400-square-mile radius: In many states, the state would have had to call out the National Guard for such an onslaught, but hunting is a passion in Wisconsin. Hunters shoot 450,000 deer every year, more than in any other state. “I’m looking for ardent hunters to help us, unless fear or their wives keep them away,” one DNR official told a Milwaukee magazine. The state extended the normal hunting season and waived the usual limit of one buck per hunter, and the hunters came out in force. The whole affair was gruesome – one official called it “hunting for slob hunters”. If you’re trying to eradicate a prion disease, you can’t very well let people take the carcasses home to eat. Bodies piled up in control stations, decomposition mingling with bleach. The 2002 hunt established a base rate of 2% for chronic wasting disease in Wisconsin deer, with the most affected areas getting up to 10%. Further hunts in 2003, 2004, and 2005 spread to wider and wider areas – and didn’t move the needle one bit. This is to say that CWD is quite a bit more common in the American deer population than BSE ever was in British cattle. Since publication, it’s popped up in Norway and South Korea. Notably, Norway doesn’t allow for the import of cervids, raising numerous questions about how it got there. There are no unambiguous cases of CWD transmission to humans, and in vivo/in vitro primate studies have mixed results. There sure are some unusually young hunters with sporadic CJD, though. But don’t worry, most of them aren’t M/M homozygotes! There is an absolute ton going on in this book. I’ve had to skim over whole sections. Parts that couldn’t be easily slotted into a narrative review include: When Gajdusek was invited to a party at Prusiner’s house, he was horrified to find his rival had purchased hundreds of New Guinean statues – all with the genitals removed.
Inline links: 2, Lyttle Lytton, 3, 4, a couple years later, concerningly transmissible to primates, omnigenic model, you might, 5, SNPedia, a 2009 post, https://substackcdn.com/image/fetch/$s_!N93S!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fced2eca3-ec58-40b8-8c13-debdb559ab8f_651x601.png, Yeah., nope, M/V heterozygotes totally get vCJD, 6, up to 1 in 2000 people in the UK have latent vCJD, bleach enemas, has an answer for you, 7, blood donations spread vCJD, going, up, 8, 9, not supposed to happen, https://substackcdn.com/image/fetch/$s_!0J8B!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F2a64b287-a7c6-4d82-bbe1-da949fc93118_1024x683.png, Ric McArthur, controversial, amongst, hunters, illegal in numerous states, trophy class animals at an earlier age, 10, Norway, South Korea, mixed results, sure are
Despite the rhetorical description of Zigas as an “actual doctor”, quite a few people – including Gajdusek – were sure he was lying about having a medical degree.
Zinjanthropus1 mentions across 1 issues

Zinjanthropus is a recurring person in the Astral Codex Ten archive, appearing 1 times across 1 issues between August 08, 2024 and August 08, 2024. The archive places it in contexts such as "Zinjanthropus writes : I think the ultimate reason that the Nietzschean idea of the superman fails". It most often appears alongside 10240, 4chan, @slatestarcodex.

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Zinjanthropus
Mention count
1
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1
First seen
August 08, 2024
Last seen
August 08, 2024
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Highlights From The Comments On Nietzsche
August 08, 2024 · Original source
Zinjanthropus writes:
Inline links: writes
zmaznevegor@gmail.com1 mentions across 1 issues

zmaznevegor@gmail.com is a recurring person in the Astral Codex Ten archive, appearing 1 times across 1 issues between August 29, 2024 and August 29, 2024. The archive places it in contexts such as "Contact Info: zmaznevegor[at]g mail[ dot]com". It most often appears alongside 10 N Park Pl, 12th Ave South, 1525 Bank St.

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zmaznevegor@gmail.com
Mention count
1
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1
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August 29, 2024
Last seen
August 29, 2024
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Meetups Everywhere 2024: Times & Places
August 29, 2024 · Original source
Contact: Egor Contact Info: zmaznevegor[at]g mail[ dot]com Time: Sunday, September 15th, 02:30 PM Location: Me Coffee Roastery, 2nd floor. 91 Chương D., Bắc Mỹ Phú, Ngũ Hành Sơn, Đà Nẵng 550000, Vietnam Coordinates: https://plus.codes/7P8C26WP+Q27 Notes: If you are planning to come, please contact me on Telegram @Zmaznevegor. https://t.me/Zmaznevegor
Inline links: https://plus.codes/7P8C26WP+Q27, https://t.me/Zmaznevegor
Zobrist1 mentions across 1 issues

Zobrist is a recurring person in the Astral Codex Ten archive, appearing 1 times across 1 issues between May 28, 2021 and May 28, 2021. The archive places it in contexts such as "an earlier example from Zobrist at FAVI". It most often appears alongside A Game of Thrones, Africa, African Americans.

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Zobrist
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1
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1
First seen
May 28, 2021
Last seen
May 28, 2021
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Your Book Review: Humankind
May 28, 2021 · Original source
What should we take from this? The usual rule is "don't get excited about a method that one company is succeeding with, get excited when someone else succeeds by copying them", so Bregman obligingly gives us an earlier example from Zobrist at FAVI. What I'm taking is that people don't need managing nearly as much as the average manager imagines. I haven't been able to manage my team nearly so closely since lockdown struck, and you know what? They're delivered just as well. Intrinsic motivation works. A lot of the time it works really well.
Zoe1 mentions across 1 issues

Zoe is a recurring person in the Astral Codex Ten archive, appearing 1 times across 1 issues between July 05, 2024 and July 05, 2024. The archive places it in contexts such as "Haidée and Zoe, maiden and her maid". It most often appears alongside 1812, Ada, Albania.

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Zoe
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1
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1
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July 05, 2024
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July 05, 2024
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Your Book Review: Don Juan
July 05, 2024 · Original source
He woke up in a cave — not quite platonically, For staring at him was a lovely maiden; Her maid (and friend) beheld the pair sardonically And gave a dish to Juan, freshly laden With eggs and fish and bread, while she symphonically Spoke Greek to him (‘twas Greek to him); he stayed in This bed, beside the sources of his aid: Haidée and Zoe, maiden and her maid.
Inline links: platonically
Zohar Atkins1 mentions across 1 issues

Zohar Atkins is a recurring person in the Astral Codex Ten archive, appearing 1 times across 1 issues between February 03, 2022 and February 03, 2022. The archive places it in contexts such as "I'm Zohar Atkins (Rabbi, Poet, R"; "I'm Zohar Atkins (Rabbi, Poet, Rhodes Scholar, Emergent Ventures Winner, and Founder of Etz Hasadeh)". It most often appears alongside 538, 55-gal drum, 750k horny men.

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Zohar Atkins
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1
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1
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February 03, 2022
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February 03, 2022
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ACX Grants ++: The First Half
February 03, 2022 · Original source
#22: Support Zohar Atkins’ Podcast I'm Zohar Atkins (Rabbi, Poet, Rhodes Scholar, Emergent Ventures Winner, and Founder of Etz Hasadeh). I'm seeking $100,000 to support my new podcast, Meditations with Zohar, which I plan to make into a weekly thing over the course of many years. The show needs patronage to support production and editing costs, and, if this is to be a weekly endeavor, my time. The show features a series of conversations with eclectic thinkers, doers, and artists I admire, with a focus on the intersection of philosophy, religion, theology, and personal principles for life. I have 10 guests already signed up and scheduled, and have recorded 3 episodes, including with Noah Feldman, Sheila Heti, and Teresa Bejan. Other guests include Tyler Cowen and Agnes Callard. The show will combine the love of learning of Tyler Cowen's Conversations with Tyler and the personal, and sometimes existential touch of Krista Tippett's on Being. The world needs high level content that is seeking, personal, and meaning-oriented. We need to talk about ideas in a way that is rigorous but also heartfelt, acknowledging our "skin in the game." This endeavor is part of my larger project of bringing the study of great texts and ideas outside academia. See here for one example. Betting on the show is a bet on my attempt to strengthen culture through better discourse, better education, better thinking, and deeper self-understanding.
Inline links: here
Zoheb1 mentions across 1 issues

Zoheb is a recurring person in the Astral Codex Ten archive, appearing 1 times across 1 issues between March 25, 2025 and March 25, 2025. The archive places it in contexts such as "Contact: Zoheb". It most often appears alongside 10 E Main Street, Fairborn 45324, 11841 Wagner Street, Culver City, 13 Mile road.

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Zoheb
Mention count
1
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1
First seen
March 25, 2025
Last seen
March 25, 2025
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Meetups Everywhere Spring 2025: Times & Places
March 25, 2025 · Original source
Contact: Zoheb Contact Info: zohebanjum[a t]gmail[period]com Time: Saturday, April 12th, 2:00 PM Location: 1111 Brickell Ave, Miami, FL 33131. We'll be in the lobby, but you can also enter through the Carrot Express. Coordinates: https://plus.codes/76QXQR65+VQ Group Link: https://discord.gg/svZeYP83MQ Notes: The meetup will go on for several hours so don't worry if you have to arrive later than 2pm. Also, if you need to show up earlier, reach out since we can be flexible about the time. We regularly host local events and also have members across south Florida. If you can't make it to this event, connect with us via Discord or e-mail to stay tuned for future opportunities!
Inline links: https://plus.codes/76QXQR65+VQ, https://discord.gg/svZeYP83MQ
Zong Lu1 mentions across 1 issues

Zong Lu is a recurring person in the Astral Codex Ten archive, appearing 1 times across 1 issues between September 01, 2023 and September 01, 2023. The archive places it in contexts such as "When Qin Zhang heard that Zong Lu had died"; "When Qin Zhang heard that Zong Lu had died, he prepared to go and mourn for him". It most often appears alongside 536 BC, ACX, Ai Jiang.

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Zong Lu
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1
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1
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September 01, 2023
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September 01, 2023
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Your Book Review: Zuozhuan
September 01, 2023 · Original source
When Qin Zhang heard that Zong Lu had died, he prepared to go and mourn for him. Confucius said, “He was a brigand for Qi Bao and an assassin for Gongmeng Zhi. Why should you mourn for him? The noble man does not earn his keep from a miscreant. He does not accept things from the rebellious. He does not taint himself with deviations for the sake of profit. He does not serve others with deviations of his own. He neither covers up unjust behavior nor commits deeds that are not in accord with ritual propriety.”
Zoomer Antimillenarian1 mentions across 1 issues

Zoomer Antimillenarian is a recurring person in the Astral Codex Ten archive, appearing 1 times across 1 issues between November 10, 2023 and November 10, 2023. The archive places it in contexts such as "Zoomer Antimillenarian writes"; "Zoomer Antimillenarian writes :". It most often appears alongside #EEGManyLabs, 23andme, @freeshreeda.

Reference entry
Zoomer Antimillenarian
Mention count
1
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1
First seen
November 10, 2023
Last seen
November 10, 2023
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Followup: Quests And Requests
November 10, 2023 · Original source
Zoomer Antimillenarian writes:
Inline links: writes
Zosimus1 mentions across 1 issues

Zosimus is a recurring person in the Astral Codex Ten archive, appearing 1 times across 1 issues between August 30, 2024 and August 30, 2024. The archive places it in contexts such as "cites to and discusses over 750 books, from Agobard to Zosimus". It most often appears alongside 38 Onslow Gardens, A Memoir of the Right Hon. William Edward Hartpole Lecky By His Wife, Agobard.

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Zosimus
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1
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1
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August 30, 2024
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August 30, 2024
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Your Book Review: The History of the Rise and Influence of the Spirit of Rationalism in Europe
August 30, 2024 · Original source
The scholarship: Lecky cites to and discusses over 750 books, from Agobard to Zosimus. When you enter a library full of old books, is your first instinct to go see what is actually on the shelves? Then this might be the book for you. It’s a bibilographical masterpiece.
Zou1 mentions across 1 issues

Zou is a recurring person in the Astral Codex Ten archive, appearing 1 times across 1 issues between June 01, 2021 and June 01, 2021. The archive places it in contexts such as "Musich and Zou write, in a way that doesn't quite let me trace back their reasoning". It most often appears alongside Alzheimers, beta amyloid plaques, FDA.

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Zou
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1
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1
First seen
June 01, 2021
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June 01, 2021
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What Do Treatments For Accelerated Aging Tell Us About Normal Aging?
June 01, 2021 · Original source
...hinson-Gilford progeria]. Inhibition of this splice site reverses the nuclear defects associated with aging. These observations implicate lamin A in physiological aging. Musich and Zou write, in a way that doesn't quite let me trace back their reasoning: It is quite likely that the same sporadic abnormal splicing of prelamin A mRNA is responsible for the genome instability in both HGPS and normal aging. I don't really g...
Zou et al (2022)1 mentions across 1 issues

Zou et al (2022) is a recurring person in the Astral Codex Ten archive, appearing 1 times across 1 issues between April 25, 2023 and April 25, 2023. The archive places it in contexts such as "This is the basic idea behind Zou et al (2022), Forecasting Future World Events With Neural Networks". It most often appears alongside API, Autocast, Conditional Pairs.

Reference entry
Zou et al (2022)
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1
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1
First seen
April 25, 2023
Last seen
April 25, 2023
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  • 23 April 25, 2023
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23
April 25, 2023 · Original source
This is the basic idea behind Zou et al (2022), Forecasting Future World Events With Neural Networks. They create a dataset, Autocast, with 6000 questions from forecasting tournaments Metaculus, Good Judgment Project, and CSET Foretell. Then they ask their AI (a variant of GPT-2) to predict them, given news articles up to some date before the event happened. Here’s their result:
Inline links: Forecasting Future World Events With Neural Networks
Zsolt Tanko1 mentions across 1 issues

Zsolt Tanko is a recurring person in the Astral Codex Ten archive, appearing 1 times across 1 issues between April 01, 2026 and April 01, 2026. The archive places it in contexts such as "Contact: Zsolt Tanko". It most often appears alongside 1108 R St, 11841 Wagner Street, 131 Colonie Center.

Reference entry
Zsolt Tanko
Mention count
1
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1
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April 01, 2026
Last seen
April 01, 2026
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Meetups Everywhere Spring 2026: Times & Places
April 01, 2026 · Original source
Contact: Zsolt Tanko Contact Info: zsolttanko[@]gmail[.]com Time: Saturday, April 11th, 11:00 AM Location: The café at Pinakothek der Moderne Barer Straße 40 80333 München We’ll have a sign. Coordinates: https://plus.codes/8FWH4HWC+XW Group Link: https://chat.whatsapp.com/Jek [remove this bit] HeDBFokxLlmceXsYhLv Notes: We’re hosting in a large cafe with a lounge area, we’ll collect together there for the afternoon and go out for dinner in the evening. This is a day-long event, join the WhatsApp group for updates throughout the day.
Inline links: https://plus.codes/8FWH4HWC+XW
zubbybadger1 mentions across 1 issues

zubbybadger is a recurring person in the Astral Codex Ten archive, appearing 1 times across 1 issues between August 28, 2023 and August 28, 2023. The archive places it in contexts such as "First place out of 999 participants is zubbybadger . Zubby is a prediction market veteran". It most often appears alongside 2024: Bullish on Blue, ACX forecasting contest, AI Advances by 2025.

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zubbybadger
Mention count
1
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1
First seen
August 28, 2023
Last seen
August 28, 2023
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  • 23 August 28, 2023
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23
August 28, 2023 · Original source
Kalshi: https://kalshi.com/markets/supercon/roomtemp-superconductor-reported Both reached the 40s to 50s! I think there just wasn’t enough smart money to drown out the people who wanted to bet on an exciting thing being true, or who were unduly influenced by a social media environment optimized to keep their attention by convincing them that an exciting thing was true. I have never claimed prediction markets are always good. All I wrote in the Prediction Market FAQ was that either a prediction market will be good, or you could make lots of free money. In this case, it was the second one. I regret I only made $30. I do hope this situation will improve over time, as over-eager forecasters get burned and dollars flow from dumb money to smarter. [EDIT: I should have included something about Metaculus here, but it’s confusing. I think the most popular Metaculus market was lower because it had stricter resolution criteria (the first replication had to be positive, instead of any replication) but that otherwise Metaculus raw probabilities mirrored everyone else’s. We don’t know how their algorithmically processed probabilities did yet and I’ll report on that information when I get it.] Salem/CSPI Tournament Winners The Salem Center and the Center For The Study Of Partisanship And Ideology, two think tanks associated with right-wing intellectual Richard Hanania, sponsored a prediction market tournament last year. Participants got $1000 in play money to bet on selected markets about current events; winners would be interviewed for a well-paying academic sinecure at one of the think tanks. Now the tournament is over. Winners have yet to be announced, but unofficially, everyone knows who they are: First place out of 999 participants is zubbybadger. Zubby is a prediction market veteran who was featured in a Washington Monthly article last year for his great track record in political betting (he’s made > $150,000 on PredictIt). Now he works as a “community manager” for Kalshi (I don’t know what this entails). Second place was Robert from Considerations On Codecrafting. He’s written a detailed reflection on his experience (part one, part two) which is my main source for this section and highly recommended. He describes himself as “having absolutely no experience with prediction markets”. Third place was Johnny Ten-Numbers, about whom I can find no further information. You can see the rest of the top 20 at the very bottom of this post. Reading Robert’s story of his experience, I’m struck by how little of the competition at the top was about predictive accuracy. Everyone in the top 20 was a very accurate predictor (Exactly equally accurate? Hard to tell.) What separated 1st place from 20th, aside from luck, was things like: Ability to move fast - both in responding to news, and in taking the other side of bad bets. Several top performers programmed bots to give them an edge here.
Inline links: Prediction Market FAQ, selected markets about current events, zubbybadger, featured in a Washington Monthly article last year, Robert, part one, part two, Johnny Ten-Numbers
Zuo Qiuming1 mentions across 1 issues

Zuo Qiuming is a recurring person in the Astral Codex Ten archive, appearing 1 times across 1 issues between September 01, 2023 and September 01, 2023. The archive places it in contexts such as "authorship to Zuo Qiuming, a contemporary of Confucius". It most often appears alongside 536 BC, ACX, Ai Jiang.

Reference entry
Zuo Qiuming
Mention count
1
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1
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September 01, 2023
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September 01, 2023
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Your Book Review: Zuozhuan
September 01, 2023 · Original source
While tradition attributes the text’s authorship to Zuo Qiuming, a contemporary of Confucius, most modern historians date its compilation to the century after. In its extant form, it’s presented interleaved with the Annals, so that after the Annals’ account of each year, with entries such as…
Zuo Zongtang1 mentions across 1 issues

Zuo Zongtang is a recurring person in the Astral Codex Ten archive, appearing 1 times across 1 issues between February 26, 2021 and February 26, 2021. The archive places it in contexts such as "General Zuo Zongtang, a 19th-century Qing dynasty official from Hunan Province". It most often appears alongside American Chinese food, Bay Area, BBQ pork rice.

Reference entry
Zuo Zongtang
Mention count
1
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1
First seen
February 26, 2021
Last seen
February 26, 2021
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Bay Area Plant-Based Meat Reviews
February 26, 2021 · Original source
I was briefly confused about whether General Tao was the same person as General Tso, or, like, his vegetarian brother or something. I looked this up and found that these are both acceptable Romanizations of the name of General Zuo Zongtang, a 19th-century Qing dynasty official from Hunan Province. He had nothing to do with the chicken - in fact, Tso's descendants had never heard of the dish. A Taiwanese-American chef with Hunanese roots invented the chicken in New York and named it after a hometown hero. Wikipedia also informs me that General Tso reconquered Xinjiang for China and ethnic-cleansed thousands of Uighurs and other Chinese Muslims, so maybe he needs to be cancelled.
Inline links: Tso's descendants had never heard of the dish
This is a vegetarian Chinese restaurant. Their website doesn’t list any inspirational backstory or whimsical daydreams, so I assume they’re a front for the mob. I ordered their vegetarian takes on Mongolian beef, BBQ pork rice, and General Tao's chicken.
The General Tao chicken was actually excellent! It looked so realistic that I did a double-take and worried they'd sent me the real stuff. The taste was 95% the usual sweet spicy sauce, and the texture was good enough that I found myself thinking back to the last time I'd had real Chinese chicken, trying to remember if it tasted different/better than this. I plan on ordering from here again and trying some of their other chicken dishes just to see if they're all this good [update: I did and they are].
Zvi Schreiber1 mentions across 1 issues

Zvi Schreiber is a recurring person in the Astral Codex Ten archive, appearing 1 times across 1 issues between August 26, 2022 and August 26, 2022. The archive places it in contexts such as "Contact: Zvi Schreiber, zvi[at]zvi[dot]net". It most often appears alongside 't Heem, 10/40 Coffee, 11841 Wagner St., Culver City.

Reference entry
Zvi Schreiber
Mention count
1
Issue count
1
First seen
August 26, 2022
Last seen
August 26, 2022
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Meetups Everywhere 2022: Times & Places
August 26, 2022 · Original source
BAGHDAD, IRAQ Contact: MA, tofiahmed117[at]gmail[dot]com, Discord: WolframSigma#1532, Telegram Time: Friday, September 2, 11:00 AM Location: Grinders Coffeeshop Coordinates: 8H568FG6+73 Event link(s): LessWrong JERUSALEM, ISRAEL Contact: Zvi Schreiber, zvi[at]zvi[dot]net, WhatsApp +972 54 569 1100 Time: Wednesday, October 19, 6:00 PM Location: Malcha technology park garden Coordinates: 8G3QP5XP+PP Event link(s): LessWrong REHOVOT, ISRAEL Contact: David Manheim, David[at]alter[dot]org[dot]il Time: Sunday, September 11, 8:00 PM Location: Outside porch of Aroma Coffee, הרצל 218, רחובות Coordinates: 8G3PWR25+MP Event link(s): LessWrong, Facebook event Notes: Please RSVP on Facebook so we can give updates if needed TEL AVIV, ISRAEL Contact: Adam & inbar M, projectscentrum[at]gmail[dot]com, inbar192[at]gmail[dot]com, Whatsapp +46762791415 (Adam) Time: Sunday, September 4, 7:00 PM Location: Hamenia industrial loft at Beit Alfa 7 (רחוב בית אלפא 7). Look for a door with ACX sign. Two floors up. Coordinates: 8G4P3Q8Q+85 Event link(s): LessWrong Group info: We've just made a Facebook group and are planning to organize monthly meetings going forward Notes: For questions contact Adam on email or WhatsApp. Feel free to bring a snack or a bottle of white wine. AMMAN, JORDAN Contact: Daniel, dnledvs[at]gmail[dot]com Time: Tuesday, September 20, 6:30 PM Location: Rustic, Jabal al Weibdeh Coordinates: 8G3QXW49+WG Event link(s): LessWrong Notes: We're hoping to grow the group, so feel free to come even if you've only read a few posts! +1s are also welcome. CAPE TOWN, SOUTH AFRICA Contact: Mark Chimes, chimes[dot]mark[at]gmail[dot]com, WhatsApp 0826568573 Time: Saturday, September 17, 11:00 AM Location: Truth Coffee Roasting, 36 Buitenkant St, Cape Town City Centre - we'll put a sign on the table Coordinates: 4FRW3CFF+3M Event link(s): LessWrong Group info: We met up pre-Covid and pre-ACX as an SSC group. Now we're getting back in the swing of things. We eat lunch and chat about philosophy, politics, and sometimes SSC/ACX blog posts. Notes: We're planning on having another meetup on the 8th October if you can't make the first. DAR ES SALAAM, TANZANIA Contact: Arno, arnorohwedder[at]gmail[dot]com, +255763998637 Time: Thursday, September 29, 7:30 PM Location: The Deck, Masaki Coordinates: 6G5X776J+X6 Event link(s): LessWrong Notes: Seeing if there are any interested people in Dar, look forward to meeting, if you are coming please send me a whatsapp. DUBAI, UAE Contact: RS, xyxyxz[at]gmail[dot]com, +971552726281 (WhatsApp) Time: Friday, September 30, 7:30 PM Location: Starbucks, Garhoud Coordinates: 7HQQ68VR+94 Event link(s): LessWrong Group info: Met once before Notes: Please RSVP on LessWrong, or message me on WhatsApp
Inline links: Telegram, 8H568FG6+73, LessWrong, 8G3QP5XP+PP, LessWrong, 8G3PWR25+MP, LessWrong, Facebook event, 8G4P3Q8Q+85, LessWrong, Facebook group, 8G3QXW49+WG, LessWrong, 4FRW3CFF+3M, LessWrong, 6G5X776J+X6, LessWrong, 7HQQ68VR+94, LessWrong