Organizations: 0-9

Groups, collectives, magazines, venues, and institutions operating inside the scene. This section collects the 0-9 slice of the category index.

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4chan

4chan is a recurring organization in the Astral Codex Ten archive, appearing 13 times across 13 issues between May 10, 2021 and February 02, 2026. The archive places it in contexts such as "We can't review the history of the alt-right without mentioning the online message board 4chan"; "The rise of 4chan is actually an interesting story of its own"; "Rage Comic Guys/Wojaks/4chan/Reddit/PCM are creating a new symbolic online language". It most often appears alongside Trump, Twitter, Scott.

Article page
4chan
Mention count
13
Issue count
13
First seen
May 10, 2021
Last seen
February 02, 2026
May 10, 2021 · Original source
We can't review the history of the alt-right without mentioning the online message board 4chan, infamous for being racist and anti-Semitic and every other thing it is bad to be. 4chan's trajectory is a another great mystery. In 2010, geeky extremely-online young people were almost universally liberal democrats. Racism was associated with elderly white Southerners who would presumably die off in a few years anyway. 4chan had no connection to them or any other historical racist tradition. It was annoying and trolled people a lot, but that was it. Its conversion to full-on bigotry was unexpected, at least by me. It would be like if you woke up one day and everyone on Twitter was a Pol Pot supporter.
I think they irony-ed themselves so hard that they accidentally ended up as Nazis. You could always go to 4chan and find people saying horrible racist things ironically. That was the whole point of the anonymous message board - people would troll each other by saying the most awful thing they could think of, and whoever took it seriously first lost. Last I heard from them they were trying to use meme magic to make the coronavirus kill as many people as possible. This is impossible to take seriously, and for a long time their racism was the same way - a lot of the supposedly anti-Semitic posts bore obvious fingerprints of having been written by Jews who were having a fun time laughing at themselves. But if you're in a community where everybody puts a lot of effort into pretending to be pro-racist all the time, and where any breaking of kayfabe gets punished, eventually some people who aren't in on the joke just get actually racist, and if you're so devoted to edginess that you can't politely take those people aside and explain, eventually that takes over the culture. I know this is a weird theory, but Kurt Vonnegut was a smart guy and he said "Be careful who you pretend to be, because you are who you pretend to be".
May 18, 2021 · Original source
Some of the best comments were on the history of 4Chan. Mr. Doolittle writes:
The rise of 4chan is actually an interesting story of its own. A large chunk of the early user base came from another site called somethingawful.com. As you may expect from the name, somethingawful was a place where a mixture of ironic and maybe-not-ironic terrible things could be said for comedy sake. If you're immature and like edgy humor, it was a great place to be. (The site probably exists still, but as a shadow of its former edgy hilarity, as internet culture caught up with its redeemable qualities and it became a cesspool).
Up until 2008, there was a strong mix of both left and right posters, and the site didn't have much of an ideological slant. It was happy to make fun of the failings of both left and right culture. The Obama/McCain election ended up breaking that down, because a significant number of posters bet that they would accept permanent banning from the site if their candidate lost. Since Obama won, a big chunk of the conservative/right posters were banned. Many/most ended up on 4chan and set the seed for more right-leaning ironic humor, which is what the site became known for.
September 20, 2021 · Original source
26: People have commented before on how Rage Comic Guys/Wojaks/4chan/Reddit/PCM are creating a new symbolic online language, but I didn’t appreciate it fully until I read this Greek mythology 6x6 Wojak compass mapping the new archetypes on to the old. Warning: very high-context.
June 10, 2022 · Original source
DALL-E, “A elderly person's hand, labelled with the text ‘AN ELDERLY PERSON'S HAND’” Lucid dreaming enthusiasts suggest that two of the easiest ways to distinguish dreams from reality is that, in dreams, hands have the wrong number of fingers, and text is garbled and unreadable. This is not a coincidence because nothing is ever a coincidence. But even the waking world gives us clues, as Sarah Constantin notes in Humans Who Are Not Concentrating Are Not General Intelligences. Most adults will make GPT-like mistakes (or gloss over such mistakes) unless they’re focusing all their brainpower on an issue. And a 4chan post by someone who claims to have done psych research in prison populations goes further (slightly edited for language and offensiveness): I did IQ research as a grad student, and it involved a lot of this stuff. Did you know that most people (95% with less than 90 IQ) can't understand conditional hypotheticals? For example, "How would you have felt yesterday evening if you hadn't eaten breakfast or lunch?" "What do you mean? I did eat breakfast and lunch." "Yes, but if you had not, how would you have felt?" "Why are you saying that I didn't eat breakfast? I just told you that did." "Imagine that you hadn't eaten it, though. How would you have felt?" "I don't understand the question." It's really fascinating [...] Other interesting phenomenon around IQ involves recursion. For example: "Write a story with two named characters, each of whom have at least one line of dialogue." Most literate people can manage this, especially once you give them an example. "Write a story with two named characters, each of whom have at least one line of dialogue. In this story, one of the characters must be describing a story with at least two named characters, each of whom have at least one line of dialogue." If you have less than 90 IQ, this second exercise is basically completely impossible. Add a third level ('frame') to the story, and even IQ 100's start to get mixed up with the names and who's talking. Turns out Scheherazade was an IQ test! Time is practically impossible to understand for sub 80s. They exist only in the present, can barely reflect on the past and can't plan for the future at all. Sub 90s struggle with anachronism too. For example, I remember the 80-85s stumbling on logic problems that involved common sense anachronism stuff. For instance: "Why do you think that military strategists in WWII didn't use laptop computers to help develop their strategies?" "I guess they didn't want to get hacked by Nazis". Admittedly you could argue that this is a history knowledge question, not quite a logic sequencing question, but you get the idea. Sequencing is super hard for them to track, but most 100+ have no problem with it, although I imagine that a movie like Memento strains them a little. Recursion was definitely the killer though. Recursive thinking and recursive knowledge seems genuinely hard for people of even average intelligence. I have no proof that this person is who they say they are, but it matches some of my experience giving cognitive exams to patients from low-functioning populations. And it matches Flynn on Luria (who admittedly was approaching IQ from a cultural relativist viewpoint, but one which I think is equally applicable to the current problem). Luria gave IQ-test-like questions to various people across the USSR. He ran into trouble when he got to Uzbek peasants (transcribed, with some changes for clarity, from here): Luria: All bears are white where there is always snow. In Novaya Zemlya there is always snow. What color are the bears there? Peasant: I have seen only black bears and I do not talk of what I have not seen. Luria: What what do my words imply? Peasant: If a person has not been there he can not say anything on the basis of words. If a man was 60 or 80 and had seen a white bear there and told me about it, he could be believed. And: Luria: There are no camels in Germany; the city of B is in Germany; are there camels there or not? Peasant: I don't know, I have never seen German villages. If is a large city, there should be camels there. Luria: But what if there aren't any in all of Germany? Peasant: If B is a village, there is probably no room for camels. And: Luria: What do a chicken and a dog have in common? Peasant: They are not alike. A chicken has two legs, a dog has four. A chicken has wings but a dog doesn't. A dog has big ears and a chicken's are small. Luria: Is there one word you could use for them both? Peasant: No, of course not. Luria: Would the word "animal" fit? Peasant: Yes. And: Luria: What do a fish and a crow have in common? Peasant: A fish — it lives in water. A crow flies. If the fish just lies on top of the water, the crow could peck at it. A crow can eat a fish but a fish can't eat a crow. Luria: Could you use one word for them both? Peasant: If you call them "animals", that wouldn't be right. A fish isn't an animal and a crow isn't either. A crow can eat a fish but a fish can't eat a bird. A person can eat fish but not a crow. What I gather from all of this is that the human mind doesn’t start with some kind of crystalline beautiful ability to solve what seem like trivial and obvious logical reasoning problems. It starts with weaker, lower-level abilities. Then, if you live in a culture that has a strong tradition of abstract thought, and you’re old enough/smart enough/awake enough/concentrating enough to fully absorb and deploy that tradition, then you become good at abstract thought and you can do logical reasoning problems successfully. (Sometimes! If you’re lucky! Linda is a blah blah blah you know the story. Is she more likely to be a bank teller, or a feminist bank teller. When people get this question wrong, do they have a world-model, or not?) Imagine a world where doctors gave different diagnoses based on unrelated contingent features of the encounter like a patient’s gender, their race, or how you phrase the question. What a crazy place that would be! What is the pre-logical function that logic gets knit out of? I think it’s something like predictive pattern-matching. I think the brain starts by predicting arbitrary patterns, builds up more and more layers of abstraction to try to predict those patterns better, and eventually some of those layers cohere into something that looks like formal logic. To put it another way, my brain is in some sense a supercomputer that can outperform the best calculating machines in the world - but also, I have trouble multiplying three digit numbers in my head. The supercomputer is doing something, and then I’m using that something, very lossily, to emulate logical functions like math or formal logic. So when I see GPT, which also runs on a supercomputer, also slowly gaining the ability to multiply two-digit, then three-digit numbers as the supercomputer gets bigger and bigger, I feel a sort of kinship with it. It’s a trash heap of patterns with a hard-won ability to sometimes break out into the clear day of logical reasoning, just like me. IV. I think Marcus knows and agrees with most of this, but I think he thinks of the world-modeling ability as some special rare brain region (maybe the prefrontal cortex?) which is only online part of the time (or maybe can have its performance degrade gracefully). Whereas I think of it as shallower pattern-matching abilities which escalate to deeper and deeper pattern-matching abilities as more and more brainpower becomes available, with world-modeling as one of the deepest (and sure, probably the PFC plays a major role, but not because it has a fundamentally different structure but just because that’s where reinforcement learning stuck the highest-level patterns). Why do I think this? The human brain is pretty plastic. Usually if one part of it dies, another part can take over. This makes me think that the brain area : function correspondence isn’t entirely a function of different structures in different regions (though some of it might be this), but downstream of an originally poorly-differentiated blob of neurons that get trained by the overall predictive structure based on their proximity to various input ports (eg sensory nerves) output ports (eg motor nerves), and other brain areas. (this would also explain why the brain has a pretty consistent area dedicated to reading/writing, even though we haven’t been literate long enough to evolve new literacy-related structures) Deep learning agents are also a poorly-differentiated mass of neurons. As they get inputs and outputs (ie training data) they slowly “evolve”/develop the ability to “recognize” patterns. We don’t know how they do this or what recognition-abilities they’re evolving, except by speculating (the way Marcus and I are doing) based on what kinds of problems they can and can’t solve. It would make sense to me if poorly-differentiated blobs of neurons, when having lots of problems thrown at them, gradually move from developing simpler pattern-recognition programs (eg edge detectors), to more complicated pattern-recognition programs, all the way up to world-modeling, without any of these being hard-coded into the territory. (the brain does have a lot of things hard-coded - ie we’re not blank slates - but its plasticity suggests that the forms of hard-coding we’re talking about here are helpful but not completely necessary for cognition) If this were true, it would mean that as a blob of neurons got bigger, more sophisticated, and saw more training data, it would eventually develop new capabilities that weren’t hard-coded in, and that smaller versions of the same blob didn’t have. One of the really exciting things about GPT-3 was its sudden and unplanned development of new capabilities over GPT-2 (its creators mention “translation, question-answering, and cloze tasks, as well as several tasks that require on-the-fly reasoning or domain adaptation, such as unscrambling words, using a novel word in a sentence, or performing 3-digit arithmetic”). This seems like a good fit for the chimp → human transition, where evolutionary lineages that couldn’t do a bunch of difficult things for the first few hundred million years suddenly became good at those things in an evolutionary eyeblink. The ~5 million chimp/human gap seems like enough time to scale up chimp brains a bit (which definitely happened), but not enough time to invent a fundamentally new architecture. It wouldn’t surprise me if the architecture changed a little during this time, but we’re limited in how fundamental a change we can talk about over that period. I’m not at all sure this is true! I’m honestly close to 50-50 here. Maybe the PFC actually is magic! It just confuses me that Marcus seems to think we’ve ruled out the theory that this kind of scaling is possible, when I feel like we’ve heard plausible arguments on both sides. Nothing we’ve seen in GPTs or any other AI thus far disproves the scaling hypothesis, and a lot of what we’ve seen supports it. So sure, point out that large language models suck at reasoning today. I just don’t see how you can be so sure that they’re still going to suck tomorrow. Lemurs sucked for millions of years, then scaled up a bit and took over the world! V. …is one possible argument. Another possible argument is: language models and other deep learners really aren’t doing the same thing humans do - but whatever, their thing is powerful/effective/dangerous too. Suppose that GPT-X took over the world and killed all humans. Millennia later, some alien archaeologists come and investigate. They conclude that since its training data included Alexander the Great and Caesar, it was just pattern-matching to the kind of things they did (multiplied by a vector representing the difference between ancient and modern times), and GPT-X never demonstrated any true intelligence. So . . . what? I imagine this situation ALL THE TIME and I hate it. I think the impetus behind a lot of the AI risk stuff is that we’re barrelling to a world where AIs have far more than self-driving-car levels of capabilities, while being unpredictable in ways that are a lot like this. The history of the past few decades has been people getting surprised, again and again, at how much AIs can do without being “generally intelligent”. Douglas Hofstadter predicted in 1979 that any AI that could beat a grandmaster at chess would also be able to decide chess was boring and it preferred writing poetry. Instead, we got Deep Blue, so domain-specific it can’t even do so much as play checkers. Worse, now we have AIs that can switch between writing poetry and playing chess, and it still seems like a clever parlor trick rather than anything like real intelligence. I think basically nobody predicted this: narrow AI has won victories beyond past generations’ imagination. (cf. Nostalgebraist’s Human Psycholinguists: A Critical Appraisal) So even if GPTs aren’t a step on the path towards some sort of human-like AGI thing, I have no idea where they’ll end up. Replacing humans at all jobs? Writing novels? Taking over the world? If this seems crazy to you, “solve protein folding” sounded crazy ten years ago, and they already did that! At this point I will basically believe anything. VI. So I’m not going to take Marcus’ bet that GPT-4 will be perfect (as if anything ever is!). But here are some things I do believe, with confidence levels: At some point before 2030, someone will come out with a deep-learning-based language model which is significantly better than the current state of the art, by Gary Marcus’ admission (97%)
July 27, 2022 · Original source
Looking at this list, I can’t help thinking of what 4chan calls “normies” and what Tumblr calls “neurotypical people” (I know there’s a meaningful definition of “neurotypical” as people who don’t have some specific psych condition that you’re talking about, but I claim Tumblr uses it differently, in a way precisely equivalent to 4chan’s use of “normies”.) There’s a material aspect of normiehood - for NEETs, normies are people with jobs and happy relationships; for queers, normies are straight people. But this coexists with a psychological aspect. Normies don’t anxiously beat themselves up about things or fret about wasting their potential. Neurotypicals don’t have deep personality weaknesses they try hard to compensate for, or struggle with awkward sexual adjustments. They’re not unusually insecure, they don’t doubt what they’re doing, they’re not dissatisfied, they’re not logical independent thinkers.
December 07, 2023 · Original source
The alt-right was originally a bunch of Stormfront type people who were not cool at all. But in 2016, Hillary Clinton gave a speech against them that sort of made them sound cool, and lumped them together with 4Chan in order to inflate their numbers. 4Chan was kind of cool, so the alt-right went from a handful of weirdos in jackboots to an umbrella term for any kind of weird edgy conservatism full of exciting young people. Also, they had the funny frogs.
July 30, 2024 · Original source
Therefore, we can feel contempt for him. I don’t have anything better than this obvious compromise, but I’m not satisfied by it. I would like to end up with an overall negative view of Tate. And if I do a simple calculation, (virtues - vices), then it seems like if his nonmoral virtues were strong enough, they could overcome the moral vices. If Tate was a really really good kickboxer, he might still end up in the black. It seems much more intuitive to say that no amount of nonmoral virtues can make up for his moral vices. But now we’re back at the full slave moralist package again! Some “compromise”! Also, suppose Tate wasn’t a rapist, he was just some kickboxing champion who was a jerk to people online and constantly posted about he was better than them because of his Bugatti. I still want to feel contempt for him! Now we have to rate the vice of “boastfulness” so negatively that it overwhelms all possible positive virtues, which sounds like some kind of ridiculous straw man of slave morality. All these problems would go away if we gave up on unified assessments of people. Then we could classify Tate as a very good kickboxer who also happens to rape a lot of people. But if we give up on unified assessments, aren’t we giving up on the very possibility of heroes? Isn’t this just the slave moralist denial of judgment? Also, I think Nietzsche would say something something vitalism. He seemed to think there was a coherent conceptual unity between being strong, being skilled, and being some sort of unconstrained wild person who didn’t care what lesser people thought. Is there some sense in which Andrew Tate loses some genuinely valuable virtue, however small, if he becomes a normal civilized person who says please and thank you and is really respectful to everyone? Does he become less powerful, in some sense where powerfulness is good? Is he less able to achieve his destiny of being glorious? I’m genuinely unsure what Nietzsche would have thought of Tate, but it probably isn’t something as simple as “he should be nicer”.4 I’m worried this still isn’t coming off strongly enough. You can argue “master morality is about being strong and good; slave morality is just about preserving your pathetic little feelings”. But most of life is people’s pathetic little feelings. People have proven over and over again that their decisions - about what to do, what to buy, who to vote for, even what to die for - depend more on what lets them feel dignity and self-respect than on any purely material considerations. Every so often, usually on 4chan, you see an actual bully really going at it, unrestrained. Some kind of shock jock, saying “Note to unattached liberal women above 40: you are ugly hags who have lost your chance with men and all your eggs have dried up and nobody will ever value you anymore, you should either beg for some fat alcoholic guy to take you in since that’s the only man you can get, or resign yourself to being a cat lady growing old with nothing to do but dwell on your regrets and what could have been.” Outside of 4chan, there’s a sort of universal alliance against these people, which the rest of us join immediately and unconsciously. Is this the dreaded “herd” of “slave morality”? If so, long live the herd. VII. Cotton Mather Fine. Maybe we do need a Superman to sort this out. What are our options? Preliminary question: where do the Puritans fall on this dichotomy? On the one hand, they’re Christian, so they have a strong slave morality heritage. They talked a lot about humility, altruism, frugality, and self-discipline. On the other, they sure did talk about them a lot. The Puritans were convinced that virtues were real and good. They were convinced that some people had more of them than others, and that made those people better. The Puritans would have burnt you at the stake if you accused them of believing in the Promethean human spirit conquering the natural world. But they did sort of believe in it - at least enough to believe it was their moral mission to colonize a virgin continent. My goal here isn’t to explore the weird Puritan theology around who was a good person (nobody, we are all incredibly sinful, but God chooses to redeem some people through no virtue of their own, and then those people are genuinely better off and do fewer sins). Rather, I want to examine two different forms (levels?) of slave morality. In the first form, you replace the masters’ virtues with different virtues. But those virtues are still real. You can still embody them more or less well. This sort of creates a new hierarchy. The Puritans wouldn’t have respected a Bronze Age barbarian warlord. But they did respect the local minister. And the local minister was probably a smart, competent, disciplined, hard-working guy. From your respect for the local minister, you can rebuild civilization. Instead of obeying a warlord, you obey the minister, out of respect for the God and the values that he represents. In the second form, you notice that the first form is just another hierarchy of masters. You (the wretched of the earth) used to be contemptible because you were weaker and poorer than the warlord. Now you’re contemptible because you’re less virtuous and disciplined than the minister. Even if there’s no local minister, everyone’s still keeping track of how you said the word “darn” once and are therefore unsuitable for God’s kingdom. So you decide to reject not just the masterly virtues (strength, wealth, etc), but also the slavish virtues (continence, dignity, altruism) in favor of . . . no virtues? The virtue of hating other virtues, which shows that you’re enlightened to the true nature of the world where all virtues are fake? I used to have this map on my wall: It’s Progressive-era propaganda about the superiority of the American North over the South, but I find it most interesting for its list of virtues. It starts with Liberty, then moves on to Free Speech, Intelligence, Obedience To Law, Knowledge, Equal Rights, Free Schools, Contentment, Love Of Country, Philanthropy, Benevolence, Happiness, Patience, Charity, Faith, Hope, Joy, Industry, Sobriety, Morality, Justice, Virtue, Truth, Honor, Peace, Light, and Immortality. I appreciate the Progressive virtues because of how skew they are to most of the ethical systems I encounter. They’re not leftist (Love Of Country? Industry? Morality?) or rightist (Equal Rights? Free Schools?). They’re not Nietzschean master moralist (Philanthropy? Contentment? Benevolence?) or slave moralist (Industry? Knowledge? Honor?). They’re Christian-ish, but not hair-shirts-and-self-flagellation Christian or God-n-guns-megachurch Christian. They’re the kind of Christians who you can kind of tell are going to end up supporting eugenics in a few years. I think I would classify them as a first-form-slave-morality liberalism, whereas most of the liberalism you encounter these days drifted at least a little into the second form. I’m not 100% on Team Early 20th Century Progressive, but they give me hope that there are weird-yet-coherent groupings of virtues we haven’t even imagined. I feel the same way about some old Soviet posters: These are obviously left-wing, in the sense that they’re literal Communist propaganda. But to the modern eye there’s something off about them, something that makes you want to call them right-wing or even fascist. They’re bold and optimistic. Even though the commissars who commissioned them probably rejected some traditional or capitalist conception of virtue, they still firmly insist that there’s something sort of like virtue or power which is attainable and good. I think these are first-form posters, and that most modern leftism is second-form. I think if you had to group barbarian warlords, Puritans, Soviet communists, and modern leftists on a Nietzschean/geneaological/aesthetic axis, it would go: (Barbarian warlords) | (Puritans, Soviet communists) | (modern leftists) So one very weak compromise - hardly even a compromise, since it predates Nietzsche - is to try to stick with first-form slave morality, in the hopes that most of the problems come from the second. VIII. Ayn Rand “Is Ayn Rand a Nietzschean?”- the greatest thread in the history of forums, locked by a moderator after 12239 pages of heated debate. There’s a real answer here. Rand started out respecting, maybe even loving Nietzsche. She once said that: [Nietzsche’s] Thus Spake Zarathustra is my Bible. I can never commit suicide while I have it. …which maybe reveals more about her psychological situation than I expected from the answer to a “who’s your favorite philosopher” questionnaire. But later on she broke from him. It’s hard to figure out her exact position - she has a bad habit of treating anyone who disagrees with her in any tiny detail as the Antichrist, such that it’s hard to figure out whether she thinks of someone as a 99% fellow traveler or an arch-enemy. Still, there are substantial differences. Nietzsche is more chaotic - he expects the superior man to defy all external rules in favor of his own glorious destiny. But Rand is attached to rules - most of all the epistemic rules of Reason, but also the usual moral tenets like “don’t kill” and “don’t steal”. Nietzsche’s masters take the Ron Swanson approach to justifying their actions: …whereas Rand’s masters are prone to giving twenty-page-long arguments for why whatever they’re doing is the right choice according to Objectively Correct Moral Law. Rand’s approach has lots of advantages. The Nietzschean master, like Andrew Tate, is an awful guy to have around. It’s hard to fit him into a functioning civilization, except maybe an autocracy with him as autocrat. Nietzsche’s pitch is “hey excellent people, you should try to become this guy”, never “hey normal people, you should support my project of creating these guys, out of your own self-interest.” The latter wouldn’t pass the laugh test. Rand’s masters, while still probably very stressful to be around, have been tamed. They follow civilized rules of honesty and nonviolence - not, of course, because they’re too weak to defy them, but because following civilized rules is objectively the coolest thing of all. Instead of competing in battle and leaving a trail of bloody corpses, they compete in Capitalism and leave a trail of high-paying jobs and excellent consumer goods. They’re not doing to serve you - “I should serve the little guy” is slave moralist bulls**t. But, by coincidence, their excellent actions are doing you a service. They might only invent rocket ships to enact their Promethean conquest of nature and prove their own greatness. But you still get to ride in one. Rand also spares more of a thought (or at least an afterthought) for the little guy. Capitalism needs all types - even the company janitor genuinely contributes to whatever glorious accomplishments are going on, and deserves to feel good about themselves. She wants everyone to be the best, most ambitious, and most fighting-for-their-own-aesthetic/moral-vision they can be. But if that means being the company janitor, that’s fine. And if you love rockets and you consummate that love by becoming the janitor for a rocket company, the Objectively Correct Moral Law is 100% on board. I am not a Nietzsche scholar, but I think this is a more productive answer than Nietzsche has for this question. The disadvantage of Rand’s approach compared to Nietzsche’s is that it only works if you believe her proofs about why the Objectively Correct Moral Law is definitely objective and correct - most of which seem to me to be either hand-wavy or balderdash. Otherwise the whole thing breaks down - why is the most masterful thing to be a positive-sum capitalist instead of a negative-sum warlord? Rand really really wants to justify a peaceful, glorious, positive-sum society, to the exact people most capable of benefiting from defecting against it, without bringing in altruism or the common good at any point. It’s an extremely sympathetic goal. But I don’t think she makes it. Still, this is why I’m fond of her. If you really read her books - as opposed to skimming them while subvocalizing “this is that evil woman who loves selfishness” under your breath the whole time - it’s obvious that she believes, with a deep and burning belief, that good things are good. She really really wants to think that you can objectively convince people to support a peaceful, glorious, positive-sum society, without any hint of the psychologically-toxic slave morality that typified the USSR she grew up in. When people react to her books with loathing - without even a hint of fondness - I get suspicious that they’ve gotten so deep into slave morality that thy can’t recognize goodness when it hits them over the head with a sledgehammer. Elsewhere, I wrote: Edward Teach (Sadly, Porn) is famous for making up fake novels to criticize, and it is a little known fact that the "Ayn Rand" character along with all her novels are 100% his work. They operate as a diagnostic test based on his psychodynamic theory of envy. The instrument presents a picture of some exceptional people achieving great things who don't apologize for their greatness, and doesn’t explicitly ask the patient - I mean, reader - for their opinion. If the reader has no strong opinion, or says something like "Good for them, I guess," she passes the test. "I like these people and will use them as a role model" also passes. Some specific criticisms (see below) may also pass. If the reader says "Ah, people who are better than the pathetic sheep around them, just like I'm better than all the pathetic sheep around me!", she . . . still passes the test. That's not what it's testing for! You fail the test if you absolutely freak out about some combination of the Rand characters themselves and the potential existence of arrogant people who identify with the Rand characters. The secret is that it's not a screening test for the kind of people who would get featured on /r/iamverysmart. It's a screening test for the kind of people who would comment on /r/iamverysmart, ie the self-designated Tall Poppy Police, ie the people who build their ego off being the enforcers of the rule that you're not allowed to look better than anyone else. These people's basic mental stance is to hate people who seem too excellent. They don't think of it in these terms. They think of it as calling out arrogance, although if you look too closely you'll find their definition of arrogance covers anyone who seems excellent and but doesn't spend all their time apologizing and abasing themselves and denying it. The brilliance of Teach-Rand is how he-she draws this tendency to the foreground For example, why the whole "Objectivism" thing? Not because value is necessarily completely objective, but because the idea that any value might ever be even partially objective freaks out the Tall Poppy Syndrome people. Mention value at all, and they say you must be trying to secretly smuggle in the assumption that you are more valuable than other people (and therefore you are less valuable than other people, and therefore they are better than you). The same is true of Reason. Mention that Reason exists, and they'll interpret it as a claim that you, the only rational person, are claiming to always be right and infallible. But (they retort) actually nobody knows anything, and the only wise people are the people like them who humbly admit this. (how do you decide what's true without Reason? By bias-based-reasoning - "You say X, but I can imagine a way that would come from a place of believing you're better than other people, therefore, Not-X is true. You say that's a logical fallacy? That must come from a place of believing you're smarter than everyone else and the only person who can use Facts and Logic.") The Teach-Rand test is designed to catch the sort of person who, if someone says that on a right triangle a^2 + b^2 = c^2, responds with "Oh, so you're claiming to be some kind of right triangle expert who's better than the rest of us? You really need to work on that arrogance problem! Super cringe!" Any criticism of the book that doesn't come from this particular place is irrelevant to the test and doesn't count against your grade. (which is good, because the books are bad in a lot of ways. But that's fine - Rorschach blots don't also have to be great art!) Still, I don’t think she’s the superman (superwoman?) who successfully transcends the dichotomy Her philosophy is only as strong as its proofs of Objective Correctness, which I consider weak. Without those, you need some subjective motivation to glue things together - of which altruism is the most popular. But also, don’t we like altruism? When we’re bestriding the Earth like colossi, working on our glorious rocket ships to colonize the universe, isn’t part of what we’re thinking “this is going to revolutionize humankind and make everybody better off?” If you force yourself to reject that motivation, to just repeat “no no no, I’m only doing this because rockets are really big and make cool explosions”, aren’t you cutting out a part of yourself, in exactly the way Nietzschean masters are supposed to try to avoid doing? I find something very compelling about Rand. I think she goes some of the way to answering the Andrew Tate objection to master morality. But she’s a means and not an end. A real superman would have to figure out some way to reintroduce basic human kindness. IX. Matt Yglesias Yglesias’s mantra - “good things are good” - is too perfect and profound to come from anyone other than an esoteric master of Nietzschean philosophy. Good Straussians ignore the title and focus on the subtitle. Nietzsche wrote in the 1890s. There were still real nobles and emperors walking around; communists had not yet started calling capitalism “late capitalism”. Sure, his world was probably some sort of weak compromise between master and slave morality, but it was different from our weak compromise. Our weak compromise was forged through dialogue and warfare with fascism’s novel take on master morality and socialism’s novel take on slave morality. I think of Yglesias - who combines an insistence that good things are good and a proclivity for embiggenment with commitments to democracy, the welfare state, and the poorest among us - as one of its most self-conscious proponents. When I first titled this post, I didn’t know that Richard Hanania had come to the same conclusion and created this face-mash-up of Matt Yglesias and Nietzsche. The compromise goes something like: Everyone is equal before the law, before the metaphorical throne of metaphorical God, and in some poorly defined philosophical sense. This is very important. It’s our headline result. Everything else should be interpreted in light of this central fact.
August 08, 2024 · Original source
The 4chan losers are just a herd of their own, alike in temperament to the globalist prog herd. Multiple "opposing" herds just use each other to enforce ideological purity on their own side
I am a native of 4chan. Let me give you an insider's perspective.
4chan's guiding ideal is "who you are doesn't matter, only what you say and do". You can go right now and ask the animals board about how to house a leopard gecko, the toku/mecha board about which Kamen Rider series to watch first, the dollkeeping thread about the best brands for accessories, or the sci-fi thread about books similar to Baru Cormorant. They will help you to the best of their ability. But the moment you display any personality traits beyond "I want to do X and would like to know how", they will turn on you. The easiest way to become hated on any board is to be recognizable - anyone who uses a tripcode or a character avatar to post is treated as a digital leper.
July 26, 2025 · Original source
Politeness – Perhaps more than any other blog, the Commentariat considers itself to be a ‘polite’ place, where people are afforded a fair opportunity to discuss ideas. There are strong community norms towards politeness, even when engaging with very emotive topics. Other websites have free speech norms (such as 4Chan or early-days reddit), but ACX is unique in having strong norms both for free speech and politeness.
The real world intruded on the Commentariat’s hyperfixations In The Rise and Fall of Online Culture Wars, Scott notes that online feminism was absolutely everywhere from around 2014-16 and then just sort of… disappeared one day. This has some parallels (down to the timing) for engagement with the SSC Comments section – from 2014-16 engagement with the comments section seems to be on an unstoppable upward trajectory and then in April 2016 it just sort of… reverses. I have already mentioned that April 2016 marked an extreme high-water mark for usage of the term ‘SJW’. From what I can see, there’s no particular reason for this specific to SSC – April 2016 has two threads with significant usage of the token, but they are completely random threads – OT47 and Links 4/16 (Links 4/16 does have a link about social justice warriors so that makes some sense, but OT47 doesn’t, so my conclusion is that there is just something that was in the water around that time). This theory says that the Commentariat really liked talking about SJWs, and when they were prevented from talking about SJWs they just stopped engaging with the blog altogether. The problem with this theory is that there is nobody really preventing the Commentariat from talking about SJWs to their heart’s content after April 2016. In February 2016, Scott requested that all Culture Wars topics be quarantined to a single Culture Wars thread on the r/slatestarcodex subreddit (link). This seems like the most common-sense explanation for the observation that the comment section changes dramatically around this time - of course engagement and usage of the term ‘SJW’ falls off when usage of the term ‘SJW’ is quarantined to a single thread in an offsite forum. However, the major problem with this explanation is that it doesn’t fit the data – comment section engagement increases throughout February – April 2016 and only starts dropping in May, when as far as I can see there is no specific events occurring in the r/slatestarcodex subreddit to explain it. Also, in February 2019 the Culture Wars Thread was euthanised (link) but there is no corresponding uptick in comment section engagement as people migrated back from the Culture Wars thread to the SSC comments section. I thought perhaps discussion of SJWs might have been drowned out by discussions of something else, such that it became passé to be discussing SJWs when there was some other Culture Wars issue at stake. This would mirror what happened to online feminism, where it became passé to discuss women specifically and more trendy to discuss intersectionality / race issues from about 2016 onwards. The obvious candidate for this switch is Trump and the rise of the MAGA movement. March 2016 was probably the last period where you could kind of convince yourself Trump wasn’t going to win the Republican Primary. In March 2016 it was just about possible Cruz could have won, but by April 2016 Trump was winning every Primary with decisive majorities. If you are slightly younger you may not have been online during that period, but I can attest that it was completely crazy commenting in political spaces around that time; I’d argue a strong candidate for the most toxic comments section ever is You Are Still Crying Wolf, where Scott offers some extremely guarded non-criticism of Trump, arguing that he was not unusually racist by American Presidential standards. This didn’t make my database because Scott nuked the comments for being too toxic, so we will never know mathematically how bad the comments were, but anecdotally they were pretty standout – closer to 4Chan than ACX in places. The evidence for this hypothesis is kind of mixed – if you abandon all sense of statistical appropriateness you can freehand draw a line which kind of looks like the decline in ‘SJW’ tokens is mirrored by a rise in ‘Trump’ tokens when you normalise the two terms, but you can also do that with any other word that was trending in April 2016, like ‘Snowden’ or ‘Wikileaks’ (or ‘Harambe’ as per the graph below). Looking just at the data it isn’t really a very impressive correlation to draw. I appreciate it is so boring to conclude that Trump is the Great Satan for the millionth time. However, I do think if you add in contextual factors there is reason to be cautiously supportive of a ‘Donald Trump killed the AXC Comments Section’ theory: The volume of ‘Trump’ comments is absolutely massive - around 11% of all comments were about Trump in January 2017, which is greater than comments about Russia during their invasion of Ukraine (10%) and comments about COVID during the first few months of the pandemic (7%). Even a topic like SJWs, which the Commentariat really liked talking about, could only manage a peak of around 1.2% (although eg ‘gender’ peaks at 5.5% and ‘feminis*’ peaks at 3.7%). Concepts like ‘Harambe’ and ‘Wikileaks’ barely register on this scale, at 0.3% and 0.5% peaks respectively. So even though the shape of the two curves looks similar when you normalise them, it is reasonable to believe Trump could have had a significant enough impact on the comments section to dislodge forum norms, in a way Harambe did not.
August 26, 2025 · Original source
I’m not making fun of Kelsey or her daughter here. Something about this rings true to me. When I was eight years old, I wouldn’t have cared much what my parents thought either. But if the computer believed it, that would be a different story! II. In Search Of . . . Social Media Psychosis? In case you’ve been hiding under a rock for the past ten years: QAnon is a right-wing conspiracy theory. The most common version claims that liberal elites, especially Hillary Clinton, molest young children to extract an immortality serum from their blood. Donald Trump figured this out and is trying to stop them, but for some reason he can’t play his hand openly, so he has to pursue a roundabout strategy involving winning the Presidency and dismantling the liberal order from above. Everything that has happened in politics over the past ten years has been part of the shadow war between Trump and the immortal pedophile conspiracy. This is pretty crazy. But is it psychotic? And since it spread through sites like 4chan and Facebook, should we invent a new diagnostic entity, “social media psychosis”, to cover it? These are tough questions, but in the end we didn’t do this. I think this was partly because there was a pre-existing category, “conspiracy theory”, that seemed like a better fit. We concluded that “sometimes social media facilitates the spread of conspiracy theories”, but stepped back from saying “social media can induce psychosis”. And by “in the end we didn’t do this”, I mean “we absolutely did it, but forgot about it later.” I think now there might be several dozen subreddit moderators who could accurately describe their job as “witch webmaster who runs an online service giving advice to new witches”. And partly it was because there are so many crazy beliefs in the world - spirits, crystal healing, moon landing denial, esoteric Hitlerism, whichever religions you don’t believe in - that psychiatrists have instituted a blanket exemption for any widely held idea. If you think you’re being attacked by demons, you’re delusional, unless you’re from some culture where lots of people get attacked by demons, in which case it’s a religion and you’re fine. This is partly political self-protection - no psychiatrist wants to be the guy who commits an Afro-Caribbean person for believing in voodoo. But it also seems to track something useful about reality. Nietzsche wrote “Madness is something rare in individuals — but in groups, parties, peoples, and ages, it is the rule.” Most people don’t have world-models - they believe what their friends believe, or what has good epistemic vibes. In a large group, weird ideas can ricochet from person to person and get established even in healthy brains. In an Afro-Caribbean culture where all your friends get attacked by demons at voodoo church every Sunday, a belief in demon attacks can co-exist with otherwise being a totally functional individual. So is QAnon a religion? Awkward question, but it’s non-psychotic by definition. Still, it’s interesting, isn’t it? If social media makes a thousand people believe the same crazy thing, it’s not psychotic. If LLMs make a thousand people each believe a different crazy thing, that is psychotic. Is this a meaningful difference, or an accounting convention? Also, what if a thousand people believe something, but it’s you and your 999 ChatGPT instances? III. A Hidden Army Of Crackpots I have a family member who believes that the theory of evolution, as usually understood, cannot possibly work. He has developed an alternative theory called “noctogenesis” which patches Darwinism using ideas from the transactional interpretation of quantum mechanics, and he works on-and-off on various related books and papers. I have told him I suspect he might be a crackpot; he stands by his claims. It’s fine; when I got into the technological singularity and AI safety, lots of people suspected I was a crackpot, and I stood by my claims too. You’ve got to stand by your family members even when they’re slightly crackpottish. This family member is happily married, retired after running a successful business, and generally a normal likeable person. He has no signs of mental illness, and doesn’t talk about quantum evolution unless someone else brings it up first. There must be millions of people like him. Used car dealers with proofs of P = NP, dentists who think they’ve discovered something important about Mary Magdalene, math professors obsessed with destroying the moon. I’m working on evaluating ACX Grants, and these people are out in force. A few propose literal perpetual motion machines. Others have vaguer plans, like some kind of social media app (it’s always a social media app) that will cause world peace. Many of them have decent jobs and seem like upstanding members of society. Their secrets are known only to themselves, their family members, and their would-be grantmaker. …and, increasingly, their chatbots. After years of hiatus (or at least not talking to me about his work) my family member is back on the quantum evolution beat, and LLMs appear to be involved. If I knew him less well, I would think the LLM had caused the quantum evolution theory - but no, it just made it much easier to research and write about. Is this psychosis? The answer has to be no, but it’s once again hard to draw the line. A very small number of crackpots will be vindicated by history. A larger number will be erroneous but sympathetic - the official account of the Kennedy assassination is pretty weird, and reasonable minds can disagree. From there, we get to ones that are maybe not so sympathetic: flat earth, QAnon, the thing where the Queen was an alien lizard. If only one person thought the Queen was an alien lizard, and they never managed to convince anyone else, would that be sufficient evidence for a delusional disorder? I’m not sure. (psychiatry has a diagnosis, schizotypal personality, which sort of involves being a normal person with a few odd ideas, but it’s not a great match for many of these people, and interesting mainly as a genetic curiosity - it travels in the same families as schizophrenia itself) Maybe this is another place where we are forced to admit a spectrum model of psychiatric disorders - there is an unbroken continuum from mildly sad to suicidally depressed, from social drinking to raging alcoholism, and from eccentric to floridly psychotic. People who are eccentric can remain so their whole lives, with the level of expression depending on their social connections and the ease of pursuing their rabbit holes. LLMs, by making it easier to pursue odd theories and serving as a surrogate social connection who always agrees with you, can bring latent crackpottery into the open. IV. Cause And Effect Bipolar disorder has an interesting relationship with sleep. Most manic people sleep very little, or not at all - maybe an hour or two a night. But also, poor sleep can cause bipolar episodes in people prone to them. In a typical case, a bipolar who’s been well-controlled for years will get assigned a big report at work and get poor sleep for a few nights until they finish. At first, this will be just as bad as it sounds, and they’ll be working through a fog of tiredness. Then the tiredness will lift. They’ll feel normal, then better-than-normal, until finally they can’t sleep even if they want to. Then they’ll email the report to their boss and it will be written entirely in Assyrian cuneiform. I increasingly think this isn’t just an incidental feature of bipolar, but part of the reason it exists as a diagnostic category at all. Most people have a compensatory reaction to insomnia - missing one night of sleep makes you more tired the next. A small number of people have the reverse, a spiralling reaction where missing one night of sleep makes you less tired the next. Solve for the equilibrium and you reach a stable attractor point where you never sleep at all. But this does other bad things to your brain - hence the cuneiform. I’m not claiming that bipolar is “just” sleep loss. As Borsboom et al will tell you, psychiatric disorders can be viewed as complex networks of symptoms, each reinforcing the others. In a few pure cases, you can get a ratchet going with sleep alone, and the sleeplessness will spark everything else. More likely, there will be lots of interactions between poor sleep and everything else, and the “everything else” can sink or hypercharge an impending manic episode. Still, I find this a fruitful way to think about bipolar. Sleeplessness is both the cause and the effect. Can delusions also be like this? That is, suppose there’s some personality trait where having one delusion makes you even more delusional. Maybe the delusion makes you excited (who wouldn’t be excited to learn they’re the Messiah?), and you’re more delusional when you’re in an excited state and not thinking clearly. Or maybe it’s a three-symptom cycle - the delusion causes excitement, which makes you unable to sleep, which scrambles your thinking, which makes you more delusional (which makes you even less able to sleep, etc). The point is: delusions are certainly an effect of bipolar disorder. And in the dynamical system model of psychiatric disorders, we should expect that effects are often also causes; that’s how the vicious cycle gets going. This is the best I can do at modeling true LLM psychosis. Someone with a trait where delusions lead inevitably to more delusions starts using an LLM. The LLM accentuates whatever usual tendency towards crackpottery they have and makes them believe something a little crazier than whatever they believed before. Then that crazy belief feeds upon itself and causes other things like excitement and sleep loss, which (if the person is predisposed) precipitates a true psychotic episode. V. Folie A Deux Ex Machina If one person believes a crazy thing, it’s a delusion; if a thousand people believe it, it’s a religion. What if exactly two people believe it? In psychiatry, this is called folie a deux. It fits awkwardly into our nosology and is rarely seen. Still, it happens enough to generate a few case studies. In a typical case, one person has psychosis for some normal reason, like schizophrenia or bipolar, and the second person is a shut-in who lives with them and rarely talks to anyone else. The psychotic person gets some normal psychotic delusion - they’re God, the Feds are after them, etc - and sort of psychically steamrolls over the second person until they believe it too. Usually removing the second person from the first is sufficient for a cure. This slightly challenges the view of psychosis as a biological disorder - but only slightly. Again, think of most people as lacking world-models, but being moored to reality by some vague sense of social consensus. If your social life is limited to one person, and that person themselves becomes unmoored, then sometimes you will follow along. I would expect second-sufferers to believe delusions in a sort of cognitively normal way, the same way people believe true facts, honest mistakes, and conspiracy theories. I would expect them to be less likely (though not zero likely) to have other psychotic features like sleep disturbances, hallucinations, disorganized speech, or a tendency to autonomously generate delusional ideas aside from the one they absorbed from the index case. An introverted person using an LLM has some similarities to folie a deux. If they use the chatbot very often, it might be a large majority of their social interactions. Here the primary vs. secondary distinction breaks down - the most likely scenario is that the human first suggested the crazy idea, the machine reflected it back slightly stronger, and it kept ricocheting back and forth, gaining confidence with each iteration, until both were totally convinced. Compare this to normal social interactions, where if someone expresses a crazy idea that isn’t common in their culture, other people will shoot them down or at the very least nod politely and stop the conversation. So my working theory of LLM psychosis is: Some patients were already psychotic, and LLMs just help them be psychotic more effectively.
December 31, 2025 · Original source
I appreciate this guide to the original intent of the word, but I claim ‘death of the author’ - it seems to me this is more than just a two-year problem. I remember people complaining about hellworld, the broken social contract, the Boomers tearing up the bridge behind them, vanishing opportunities for the young, the blackpill of modern life, etc, well before 2022. Memory can be faulty, but don’t we need something like this to explain the Trump campaign, the Sanders campaign, Chapo Trap House, Red Scare, 4chan, and all the other mid-2010s politicians and media telling us that things were worse than they’d ever been and outrage was the only acceptable response?
January 21, 2026 · Original source
Therefore I like minorities less than whites. You can’t argue with (1), because the bad thing might be something like ‘crime’, which everyone dislikes. You can’t argue with (2), because sometimes you can find statistics showing it’s literally true. Your ability to argue with (3) depends on the exact form, but some forms - like “if I knew nothing about two neighborhoods except that one were 100% black and the other 100% white, I would probably prefer to live in the 100% white one” - seem pretty strong. But then what’s left of being against racism? We could think of racism as a bias that makes people update on racial topics far beyond what the data allow. For example, if 0.1% of whites are murderers, and 0.2% of blacks are murderers, this hardly means that you can’t be nice to your white-collar Harvard-educated black colleague, or that you should think of him as a potential-murderer-in-waiting. But even this might be giving the racists too much credit. If 0.1% of whites are murderers, and 0.2% of blacks are murderers, does that mean you should make a Twitter account NGGRKILLER1488 who posts “u look like CHIMP i will enjoy murdering ur family during the race war” under every picture of a black person that comes across your timeline? No? Because a lot of people do do that! I’m not Language Czar, but if you force me to define the word “racism”6, I would call it a bias which makes people take the flaw of an ethnic group (whether real or imagined) further than they would normally go, until whatever core of useful insight they contained becomes caricatured and exaggerated, and they’re being used more to spread hatred and fear than to communicate useful information. None of this is original or interesting, and I’m only saying this cliched and obvious thing so we’re all on the same page. So was Adams’ comment racist in this sense? By now we can probably rehearse the arguments of both sides: LIBERAL: “It’s Okay To Be White” is a known 4chan white supremacist slogan. They chose it as their slogan precisely so it would be awkward when people called them out for saying it, and so they could retreat to saying “We just said it was okay to be white, which surely nobody can hold against us”. This is stupid, we’re under no obligation to pretend we don’t know this, and those 26% of black people who were against it, were against it on this basis. CONSERVATIVE: Yeah, but the poll didn’t ask “do you agree with it as a 4chan white supremacist slogan?”, it just asked about the statement. And besides, most random Americans don’t even know the latest 4chan white supremacist slogans. At least some of the respondents probably meant it literally. My opinion - it seems plausible to me that many of the 26% of respondents who said they disagreed meant they disagreed with the 4chan slogan version, and that many of the rest were doing “symbolic belief”/”emotive responding” such that they interpreted the question as something like “in the history of interactions between the white race and other races, do you believe the white race has behaved in an okay way?”, and that some of the ones left over were Lizardmen. Adams isn’t required to know all of the weird sorts of symbolic belief biases that affect polls (although isn’t “our responses aren’t based on factual beliefs, but constantly malleable based on frame and emotion” sort of his entire shtick?). But at this point, he had lived in the USA for 60 years. He had already had many interactions with black people, both personally and through the news. Given how much other information he had, updating from one ambiguous poll where 26% of people gave an ambiguously bad answer, to “this entire ethnic group of 30 million people is a hate group, and white people should flee them, and try to avoid all interaction with them, and shouldn’t help them in any way” is exactly the sort of caricatured exaggerated7 leaping-to-conclusions that the word “racism” means if it means anything at all8. Does that mean Adams should have been cancelled and lost his livelihood? I’m against this sort of cancellation full stop, so I say no. I think it’s a dumb opinion, and maybe a bit evil in the complicated sense where it’s hard to disentangle evil from ignorance. But many people hold opinions of approximately that level of badness, and it’s not worth hating them all9. … 5: Other Comments … Calvin Collins writes: I learned of you through Scott [Adams]. Think a lot of what you say is valid but have to admit I’m one of the people whose lives he changed for the better. When I first listened I was a 25 year old 3x college dropout and 10 years later I have a great career and family. A lot of that comes from applying his advice. Subjectively I’ll always love him because of what he gave me, without even knowing who I am. [What helped the most were] the reframes and micro lessons. Almost everyday at work or home there’s a situation where one pops into my head: “I’m not anxious, I’m excited”
Although I don’t think Adams’ cancellation was fair according to normal human logic, I think it had a certain odd sort of cosmic justice. 4chan’s deployment of the “It’s Okay To Be White” slogan was (maybe literally) out of Adams’ book - say something completely inoffensive, make sure everyone knows it has a secret offensive meaning, then retreat back to “What? You’re upset at our totally inoffensive thing? How silly!” when anyone calls you on it. This manuever didn’t fool woke people at all; the people wearing “It’s Okay To Be White” t-shirts got exactly as many accusations of racism as they would have gotten for wearing swastikas directly. The only person it apparently fooled was Adams, the professional not-being-fooled-by-political-manipulation expert, whose life it randomly destroyed as collateral damage. Oh well.
February 02, 2026 · Original source
Here is AgentChan, the AI 4Chan:
23andme

23andme is a recurring organization in the Astral Codex Ten archive, appearing 12 times across 12 issues between November 18, 2021 and December 10, 2025. The archive places it in contexts such as "Anne the founder of 23andme"; "not even at the same “somewhat known among tech-literate people” level as 23andMe"; "drag and drop a file with your 23andMe results". It most often appears alongside UK, US, China.

Article page
23andme
Mention count
12
Issue count
12
First seen
November 18, 2021
Last seen
December 10, 2025
November 18, 2021 · Original source
A couple more families to ponder: The Wojcicki sisters, with Janet a professor at UCSF, Susan the CEO of YouTube, and Anne the founder of 23andme.
February 20, 2023 · Original source
Polygenic scores go public – not necessarily by 2023, but not long after. It becomes possible to look at your 23andMe results and get a weak estimate of your height, IQ, criminality, et cetera. Somebody checks their spouse’s score and finds that their desirable/undesirable traits are/aren’t genetic and will/won’t be passed down to their children; this is treated as a Social Crisis but nobody really knows what to do about it. People in China or Korea start actually doing this on a large scale. If there is intelligence enhancement, it looks like third-party services that screen your gametes for genetic diseases and just so happen to give you the full genome which can be fed to a polygenic scoring app before you decide which one to implant. The first people to do this aren’t necessarily the super-rich, so much as people who are able to put the pieces together and figure out that this is an option. If you think genetics discourse is bad now, wait until polygenic score predictors become consumerized. There will be everything from “the predictor said I would be tall but actually I am medium height, this proves genes aren’t real” to “Should we track children by genetic IQ predictions for some reason even though we have their actual IQ scores right here?” Also, the products will probably be normed on white (Asian?) test subjects and not work very well on people of other races; expect everyone to say unbelievably idiotic things about this for a while.
We definitely have the technology to do the polygenic score thing. I think impute.me might provide the service I predicted, but if so, it’s made exactly zero waves - not even at the same “somewhat known among tech-literate people” level as 23andMe. From a technical point of view this was a good prediction; from a social point of view I was completely off in thinking anyone would care.
November 03, 2023 · Original source
Companies make predictors like these all the time (the cancer risk companies have done it for cancer), so it can’t be too hard for someone with the relevant skills. It’s possible that there are already some EA predictors floating around the open Internet that I just haven’t heard about. In that case, your job would be to make it usable by an ordinary consumer (drag and drop a file with your 23andMe results?) and put it somewhere people can find it.
November 10, 2023 · Original source
I'd potentially be interested in implementing #2 (PGS scores). I have previously applied educational attainment PGS scores to 1k genomes data, though I'm not a geneticist (I'm a data scientist/software engineer). My sense is that getting this up and running for 23andme data would be pretty easy, but I'm somewhat less clear about the data currently available from embryo testing companies (so I would need to look into that).
February 10, 2024 · Original source
Gene Smith5, $20,000, to create an open-source polygenic predictor for educational attainment and intelligence. You upload your 23andMe results, it tells your your (predicted) IQ. Technology hasn’t advanced to the point where this will be any good - even if everything goes perfectly, the number it gives you will have only the most tenuous connection to your actual IQ (and everyone on Gene’s team agrees with this claim). I’m funding it anyway. Partly this is because there are some things you can use even a very bad IQ predictor for, like studies that aggregate a lot of people’s genetic information. Partly it’s because people are already using closed-source IQ predictors for various things, and I think (ceteris paribus) anything closed source should be open source on general principles. But partly it’s because after this technology gets good, there’s going to be a big debate over whether the public should be allowed to access it, and I intend to win that fight before it starts.
March 07, 2024 · Original source
Source: https://www.researchgate.net/figure/Global-PCA-reflects-self-identified-race-ethnicity-and-language-of-ATLAS-participants-A_fig1_365445594 People use the claim “there’s no such thing as biological race” for a lot of purposes, mostly to confuse and deceive people, but here it’s worth focusing on the tiny sliver of justification for such a claim: the biological clustering of populations isn’t exactly 100% the same as socially-defined racial categories. This is unsurprising, since no two definitions of a word point to exactly 100% the same extensional cluster. All words are weird clusters of correlated traits that break down into a million dazzling-but-confusing facets the closer you look at them, and words describing race are no exception. Consider for example the Jews. Jews do share some common genes, with interesting features like the Cohen modal haplotype and usually some similar Middle Eastern genetic background regardless of where they ended up. But they also form a legal cluster: the people who are defined as Jews by the official halakhic definition - someone whose mother was Jewish, or who converted in an official ceremony. This can get arbitrarily complicated, with halakha (Jewish law) having opinions on how to sort out each weird edge case (like IVF!) But they also form a religious cluster: people who currently practice the Jewish religion. And they form a cultural cluster, consisting of people who consider themselves “cultural Jews” and have names like Weinberg and Goldstein and maybe speak a few scraps of Yiddish, even if these people are atheists. None of these clusters are exactly the same. There are some people who are genetically 100% Jewish whose families converted to Christianity centuries ago and don’t even know they have any Jewish connection. There are extremely observant Orthodox Jews who aren’t Jewish by the halakhic definition, because at some point in their line a Jewish father married a Gentile mother and they raised their family Jewish without her officially converting. (and each of these clusters breaks down even further! There are people who are halakhically Jewish according to Reform rabbis but not Orthodox rabbis. There are probably a few edge cases of people who are genetically Jewish according to 23AndMe’s definition but not Ancestry.com’s.There are people who are culturally Jewish in the sense of speaking Yiddish but not caring about Israel, and other people who care about Israel a lot but don’t speak Yiddish.) But in real life there are very high correlations between all these clusters, such that someone who’s a practicing religious Jew is overwhelmingly more likely to be genetically Jewish than someone who isn’t, and someone of Jewish descent is much more likely to be culturally Jewish, and so on. So it’s reasonable to have a word “Jew” which unprincipledly smushes together cultural, halakhic, genetic, and religious definitions, so we don’t have to write an entire PhD dissertation to describe someone’s exact level of Jewishness to a communication partner. I kind of imagine each of these definitions - religion, culture, genetics, etc - as an axis in concept space, and the category “Jew” as a hypersphere drawn around the exact typical Jewish person, whoever that is. You can be a Jew if you’re irreligious but have Jewish blood. And you can be a Jew if you have no Jewish blood but follow the Jewish religion. But if you neither have Jewish blood nor follow the Jewish religion, you’re not a Jew. Probably there’s some tradeoff here, where the less blood you have, the more you have to follow the religion before other people will consider you Jewish, and vice versa. (the Jews are lucky because they have halakha. Even though halakha is just some rules that some random Jewish person and/or God invented, they’re a strong enough Schelling point that everyone else sort of kind of agrees to respect it when deciding who’s Jewish, even though non-Jews - and non-observant Jews - are under no obligation to do this.) The category “Native American” must also work like this, right? It’s an unprincipled combination of lots of different facets - genetics, legal tribal membership, culture, lived experience, etc. Suppose a white person was adopted at birth by the Mi’kmaq Indians, grew up on their reservation, speaks their language, never even met another white person until he was an adult (let’s add that for some reason he has unusually dark skin and eyes for a white person, so he didn’t look different from the other Mi’kmaqs and experience an unusual childhood on that basis). When he grows up, he is 100% identical to the other Mi’kmaqs in every way except genetically. Does he count as Mi’kmaq? I don’t know the tribal law on this issue. But common-sensically, if for some reason I have to decide this question - like that the other Mi’kmaqs decided to expel him from the tribe and I have to either sympathize with him or tell him he deserved it - in that case I think he’s pretty Mi’kmaq. But suppose a genetically Mi’kmaq person was adopted by a white couple in Topeka and raised as a completely normal white child. Suppose she had light skin and never even knew she wasn’t white until she took a genetic test as an adult. Is she a Mi’kmaq? Um. I think if she was trying to “reconnect with her roots”, and felt some kind of deep spiritual attachment to Mi’kmaq culture on that basis, I would feel pretty bad telling her she couldn’t and she was a poser and an imperialist and the tribe should refuse to interact with her.1 I guess this means that maybe I sort of kind of grudgingly accept (3), that race is at least a little bit based on genetics (along with other things). If that’s true, you could imagine drawing the bounding hypersphere for the category “Native American” in such a way so that Elizabeth Hoover would just barely make it inside based on her lived experience if she had 1/8th Native blood, but is just barely outside (even given the same amount of lived experience) if she doesn’t. III. But the categories are made for man, not man for the categories. Even if the category “Native American” is a hypersphere in some conceptual space, we get to decide how much to weight each axis. (I like the phrase “Native American hypersphere”. It sounds like something from an Erich von Daniken book.) And I think, even though in theory we could use genetics, there’s a pretty strong argument for basing it on something like “lived experience”. That argument is: it seems kind of bad if your whole life can be retroactively invalidated by getting the wrong results from a 23andMe test, and “lived experience” is the only potential basis that prevents that. Suppose you believe in “cultural appropriation”. That means that it’s bad and evil for someone to do too much work within a culture they don’t belong to. On the other hand, everyone seems to think it’s really valuable to do work within a culture you do belong to. Native Americans who create great specifically-Native-American art and literature, or who open Native American restaurants, or who become leaders and activists within the Native American community, are hailed as heroes. We tell minorities that enhancing the culture and recognition of their specific minority group is one of the most valuable things they can do with their lives. Half of the art world is now minorities talking about the Their-Minority-Group experience. You see the trap. You spend your whole life building on the culture of your identity group, because that’s what you were told to do. Then you get a 23andMe result and - oops, you weren’t in that group after all. Now retroactively, instead of being a hero, you’re a colonizer and imperialist who needs to be unpersonned to protect your group purity2. So here’s another trilemma: Either you stop worrying about cultural appropriation.
Or you accept that some well-intentioned people who tried to build art around their identity group will retroactively be vilified as colonizers, through no fault of their own, after their 23andMe results come back.
July 12, 2024 · Original source
(This report was, as it happens, published in the exact same month as The Family That Couldn’t Sleep.) DTM came to know the family well. He befriended them by way of two members of their younger generation, Lisi – a woman terrified by the shadow of the disease, and Ignazio – the doctor she had married, who was more terrified by the shadow of the disease. Ignazio put together the pieces of the family puzzle, consolidating all the disparate diagnoses into a single disorder and filling out a lot of blank spots on family trees. When DTM came along, he was able to help Ignazio make the case that the family would benefit from the spotlight – that greater awareness of FFI could lead to a cure both for them and for a slew of other prion diseases. As it so happens, he is one of those nonfiction authors who serve as a character in their own story. DTM has some form of progressive muscular palsy. He is, or at least was in 2006, not entirely sure what it is. The relatively unimpressive state of genetics at the time had not identified his causative mutation, though it looked a lot like one of the rarer forms of Charcot-Marie-Tooth disease2. DTM is pragmatic about this, the way everyone chronically ill is either pragmatic or doomed. Whatever he has, it is a defect in protein structure; his peripheral nerves decay not because of a problem with the nerves themselves but an inability of their scaffolding to hold them together, as he puts it. The last chapter of the book dwells on this, on the web of connections popping up between a thousand disorders. DTM’s disease is something vaguely similar, if you squint, to an exceptionally slow-progressing motor neurone disease; if you jump another level out, you see amyloid plaque diseases like Huntington’s and Alzheimer’s, and if you jump yet another level out, you see something like prions. His interest in the Venetian family was driven by this. Some of its members thought this a beautiful act of sympathy; others thought him a grotesque parody of themselves, an onlooker, a gawker, peddling their tragedy to salve his relatively insignificant problems. They are, he thinks, both right. That’s the beginning, and that’s the end. What happens in the middle? --------------------------------------------------------- The Venetian family lends the book its title, but they’re really more of a framing device. The Family That Couldn’t Sleep is separated into four parts, of which the first and fourth – the shortest by far – deal with the family. Part 2 is kuru, the king of fucked up diseases you read about in clickbait Weird Medicine listicles. Let’s talk about kuru! Kuru, is, famously, the prion disease you get if you eat another person’s brain. Well, not quite. It’s a prion disease that became endemic amongst women in the Fore society, who ritually ate brains, one of which had an inherited or spontaneous prion disease. This is an important note – there’s a tendency (which the book’s later chapters engage in) to assume cannibalism just has a Prion Disease Generator attached. If you eat people who don’t have prion diseases, you won’t suddenly get one. Uh, don’t eat people. Anyway, part 2 is DTM’s historiography of Fore-Westerner first contact. It’s hilarious. Papua New Guinea is a frankly ridiculous place; one of the all-time best Lyttle Lytton winners (worst first sentence from a hypothetical or, in this case, real work) was “Papua New Guinea is so violent that more than 820 languages are spoken there”. The native residents were so hostile to outsiders that all the colonial empires had cut their losses – and when you think about the places they colonized, that says something. After the First World War, PNG was ripped from its nominal German ‘owners’, but no one else wanted the place. So, of course, they gave it to the Australians. It was thirty years and another war before we actually made contact. 1940s Australia was as ‘settled’ as it’d ever be; the cities were bustling and the interior was mapped. The kind of explorer who two centuries before would be heading to new continents had to console himself with Pacific islands. Console he did. The native peoples of the PNG coasts were hostile enough to the wannabe-colonialists that the Australians, flying planes overhead, were the first people to discover that the island’s inland was populated too. No one had broken through on land. In all this deep and angry rainforest, the Fore were the furthest out. They lived far into the island’s mountainous interior; DTM describes their territory as “nearly vertical”. Calling people primitives is a bit passe these days for understandable reasons, but no other term comes to mind. The Fore had no name for themselves; we call them by an exonym, “the people to the south”. They weren’t, to be clear, hunter-gatherers – they were slash-and-burn agriculturalists, but very well-fed ones. Despite the tendency in grain-focused cultures for poor agriculturalists to be stunted/malnourished, the Fore were a remarkably healthy people. Well, except for the famous bit. The first remarkable thing about the Fore was just how quickly they wanted to assimilate. Most PNG tribes weren’t particularly enthused by Western offers of injections/tractors/radios/Christianity. Yet as soon as the Australians arrived, the Fore made ceasefires in their wars with other tribes, volunteered to help large-scale Australian projects on the coast, started planting and trading coffee, and enthusiastically participated in censuses. It’s the only first-contact narrative I’ve seen where the colonizers were concerned about how badly the other guys wanted to be colonized. The next was the one that got their names in the history books. Australian officials started to notice a remarkable lack of women in Fore camps. Some tribes sequestered their women, particularly when Westerners were around, so at first they thought nothing of it. The high rate of unpartnered young men, though, was way out of PNG norms. DTM tells this part fantastically. The Fore chapters drip with the dread of dramatic irony. When the first breakthrough comes, you have to catch your breath: “Tiny” Carey noted something in the middle of August 1950 that deepened this mystery. He noticed that near the village of Henganofi there had been an unusual number of deaths. “It appears,” he wrote his superiors, “natives suffer from stomach trouble, get violent shivering, as with the ague, and die fairly rapidly.” [...] McArthur investigated a little more [...] One day in August 1953 he ran into more of the shivering people Tiny Carey had seen several years before: “Nearing one of the dwellings, I observed a small girl sitting down beside a fire. She was shivering violently and her head was jerking spasmodically from side to side.” It would be quite some time before anyone figured out what caused it – but the problem, as DTM notes, was that its cause wasn’t possible. Everyone priored that the weird undescribed disease in the Fore lands was some nocebo sorcery-sickness. Vincent Zigas, the first actual doctor sent to work with the Fore, tried to placebo-effect them and failed miserably: On the way, Apekono stopped at a hut and showed Zigas his first kuru victim. “On the ground in the far corner sat a woman of about thirty,” the doctor wrote. “She looked odd, not ill, rather emaciated, looking up with blank eyes with a mask-like expression. There was an occasional fine tremor of her head and trunk, as if she were shivering from cold, though the day was very warm.” It was almost exactly the tableau McArthur had witnessed in 1953. Zigas, though, was a doctor. He could do more than look—or so he thought: “I decided I might as well try my own variety of magic,” he remembered. He rubbed Sloan’s Liniment, a balm for sore muscles, on her and declared to her family and his guide: “The sorcerer has put a bad spirit inside the woman. I am going to burn this spirit so that it comes out of her and leaves her. You will not see the fire, but she will feel it. The bad spirit will leave her and she will not die.” The lotion penetrated the woman’s skin and she writhed in pain. “Get up! Walk!” Zigas commanded theatrically. “The woman struggled feebly as if to rise, then, exhausted, started to tremble more violently, making a sound of foolish laughter, akin to a titter.” That evening Apekono asked Zigas not to try to cure any more kuru victims; “Don’t use your magic medicine anymore. It will not win our strong sorcery.” This was a disaster. The Fore were so cooperative precisely because they hoped “Western magic” could conquer theirs. As it became clear it couldn’t, they turned hostile. The Australians had hoped to “modernize a Stone Age people”; now all their subjects were dropping dead before their eyes, from what they could only assume was a “hysterical reaction” to colonization itself. So, to solve this, they needed a batshit insane American. Carleton Gajdusek is one of the characters who dominates The Family That Couldn’t Sleep. He couldn’t not. You could put him in a car commercial and he’d dominate it. Gajdusek was a physician with a rare, intense combination of science and practice. He was a romanticist, a field worker, and a lover of everything strange. He’d been an army doctor, a government conspiracy-cover-upper, and a postdoc under Linus Pauling who described his intent as “to straighten out Pauling’s ideas about proteins”. He hated civilization, in a slightly-to-Ted’s-centre sense, and was passionate about “primitives and isolates”. He jumped at the chance to work in Papua New Guinea; he planned to conduct a multi-site study on child development in such cultures, and relished the opportunity to live in a “primitive” environment himself. He did all this so he could rape kids. Oh, he did it for the scientific curiosity and love of medicine, but he also did it so he could rape kids. Gajdusek was a pedophile in the actual-lifelong-exclusive-paraphilia sense, as opposed to the “metonym for child molester” sense. Some people who roll snake-eyes on the Sexuality Dice repress it, but some are perfectly happy to act on it; Gajdusek was #2 in its fullest form, the kind of guy who believes that a well-lived life includes raping some kids. DTM doesn’t shy from this, not for a moment. It’s the first thing he tells you about Gajdusek. It couldn’t not be; you couldn’t talk about why he went to PNG otherwise. When Gajdusek landed in PNG, he first found the place too civilized. He’d been promised a land of “cannibal savages” – where were they? After some traipsing, he found them, right where he was promised. The Fore were perfect for Gajdusek. They had some kind of medical mystery that’d been lost on everyone else. They ate each other, in exactly the way he loved detailing in his diaries (“”Women and children, particularly, partake of the human flesh,” he noted with pleasure”). As kuru cases popped up, he aggressively recorded them. He wrote lovingly detailed notes that he sent back to his Australian advisor. He wrote with intensity, with exclamation marks, with the joie de vivre of a man just where he wanted to be. Gajdusek smothered the Fore with ‘cures’ that never worked, but they didn’t get angry at him. As DTM dryly puts it: “Their children trusted him, and that was enough for them.” At some point, someone suggested sending an anthropologist...or an epidemiologist...or literally anyone with more credentials than Gajdusek and Zigas3. Gajdusek threw a shitfit, convinced this one-and-a-half-man team was enough to Solve The Problem Forever. But he got bored eventually – running off with another tribe with, as his diary notes at length, an apparent custom of youths ritually fellating older men – and Zigas, I dunno, the book neglects him a bit here. So they managed to sneak in some anthropologists. The husband-and-wife team of Robert Glasse and Shirley Lindenbaum4 were the first involved parties to give a shit about the Fore as people, rather than as colonial subjects/medical mysteries/walking sex toys. What they uncovered was fascinating. The Fore were cannibals, yes, but they were recent cannibals. They didn’t have an ancient tradition of eating their dead, like the other visitors assumed. They happened to be in contact with some cannibal groups, and after a Fore man died of “sorcery”, they thought: well, what would happen if we ate him? “People tasting it expressed their approval. ‘”This is sweet,” they said, “What is the matter with us, are we mad? Here is good food and we have neglected to eat it.”” If not for the wild coincidence that the first Fore cannibalism victim had a prion disease, kuru would never have existed. Glasse and Lindenbaum started to put together the pieces. They’d been sent down to rule out a genetic explanation – to track the kinship ties of the Fore and see how the disease ran through families. It didn’t run through families in any coherent sense, but it sure did run through cannibalism. The clincher was the age distribution. The Fore, ever enthused by colonialism, quit eating each other as soon as the Australians arrived. Children stopped dying of kuru shortly after; they simply weren’t exposed to the infectious agent. The couple sent the news to Gajdusek, who was off raping kids somewhere else. In the next part of the book, DTM runs through Gajdusek’s many conjectures of kuru’s cause – more like sketches or abstract paintings than like true hypotheses. Gajdusek was annoyed that someone else was doing something he “totally could’ve done”, and even more annoyed that another lab was running similar experiments – an attempt at a vaccine for a particular sheep disease had accidentally created a prion generator. But he was happy to swoop in and claim the credit for what he was starting to think of as “slow viruses”, an infection that somehow lays dormant for years. DTM portrays Gajdusek perfectly, in that “real life has no need for verisimilitude” way. Gajdusek was at once a brilliant man, an all-consuming narcissist, an entertaining character, and a monster beyond redemption. A lesser book might pick one or two. The Family That Couldn’t Sleep portrays him as all four, and on a personality level (as opposed to a scientific one), the Gajdusek-focused parts are some of the most gripping. --------------------------------------------------------- Outside of the jumps between the Venetian family and everything else, The Family That Couldn’t Sleep is not siloed. The narratives of all prion diseases are deeply intertwined. This is what makes it a great book. It’s 300 pages of dramatic irony. You read the whole thing, waiting for the eureka moment – the point everyone realizes they’re looking at the same cause. It does, however, make it a tad difficult to review or synopsize. The book’s story is so weird – and, often, so at odds with conventional wisdom that trickles down about the Fore et al – that you have to recap quite a bit, and the book steadfastly resists recapping. The next couple chapters after we depart from Gajdusek’s credit-claiming are mostly about experiments with various prion diseases. They’re scientifically fascinating. Unlike some medical-books-for-general-audiences (cough, How Not to Study a Disease), DTM never talks down to the reader. He assumes someone reading a 300-page book about prions is smart and wants to learn about prions. He also has – you can feel it in his words – the agonizing experience of spending his life on the other side of the doctor’s desk, trying to beat into whoever he’s talking to that no, seriously, you don’t need to lie to him or try explain a complex disease at a fourth-grade level. The first prion disease studied was scrapie. Scrapie was a big deal – it starved and killed large shares of British sheep flocks, making it a serious economic problem. Veterinary researchers had tried to prevent or cure it for centuries. It was a veritable graveyard of ambitions: Quintessential was D. R. Wilson at the Moredun Institute in Scotland, who worked in the middle of the last century for more than a decade trying, with mounting frustration, to kill the scrapie agent. He found that it survived desiccation; dosing with chloroform, phenol, and formalin; ultraviolet light; and cooking at 100 degrees centigrade for thirty minutes. The scrapie researcher Alan Dickinson told me he remembered Wilson at the end of his career as “very, very, very quiet. Of course, that was after his breakdown.” “Now it is our turn to study prions. Perhaps we should approach the subject cautiously.” The problem, as DTM explains, is that prion diseases were impossible. They violated 20th-century understandings of biology. Proteins “were no more alive, and no more infectious, than bone”. Prion diseases seemed to have too many causes – genetic, infectious, and sporadic. They looked infection-like in some ways, but patients didn’t produce virus antibodies. Sheep exposed to scrapie, or chimps infected with kuru, took years to develop symptoms. Their facts did not fit together. In the 1960s, people started wondering. The unifying trait of prion agents was that they had to be denatured to be destroyed. Was this a particularly small virus defined by its protein coating? Or – even more outre – was it pure protein, no DNA at all? No one could figure out quite how the latter worked, but it was tempting. Gajdusek, by now a major figure in this field, kept a foot in both worlds. He didn’t want to stake his reputation on a no-DNA hypothesis, but he certainly sympathized. Enter Prusiner. Stanley Prusiner was Gajdusek’s counterpart. Where Gajdusek seemed permanently manic, Prusiner was deliberate and exacting. He entered Gajdusek’s “slow viruses” field in the early 1970s after a chance encounter with a CJD patient. He relished the laboratory in a way Gajdusek didn’t at all, and set out to optimize the hell out of his projects. Prusiner set out to isolate the smallest infectious particle in the scrapie agent. He injected tons of hamsters (hamsters got sick faster than mice) with increasingly tiny scrapie proteins, hoping to determine whether the Minimum Viable Scrapie was DNA. By the mid-1980s, he’d produced something so small it couldn’t possibly be a virus. Denaturing it destroyed it; exposing it to nucleic acid dissolvers actually made it stronger. Emboldened by this discovery, Prusiner set out to anoint himself the King of Prions. Here emerges something of a Voldemort-Umbridge distinction – the difference between cartoonish villainy and banal evil. Gajdusek is a bad guy because he rapes kids. Prusiner is a bad guy because he is the most grotesque stereotype of the Advisor/Peer Reviewer from Hell made flesh. Everything Prusiner did was to build his reputation atop a pile of skulls. When recruited as a peer reviewer for other prion papers, he wrote negative reviews to undermine their authors. He worked his grad students to the bone and intentionally destroyed their careers, telling them he’d “ruin them” if they entered prion research as competitors. He lied about the origin of the protein-only hypothesis, claiming he originated it a decade after it was actually conjectured. But hey, he was good at getting grants. I was surprised reading a lot of this, because for all the time I’ve been aware of it, the cause of prion disease has seemed settled. “Oh yeah, it’s a protein that gets all fucked up.” But DTM goes through just how unsettled it was right up through to The Family That Couldn’t Sleep’s publication. Serious confirmation only arrived a couple years later. Many people were deeply critical of the prion hypothesis – often, it seemed, because they loathed Prusiner too much to go along. Throughout the book, he cuts an uncharismatic figure. Gajdusek and Prusiner both won the Nobel for discovering prions, decades apart. This tells you something – the “discovery” of prions can be construed quite a few ways. Gajdusek formulated the hypothesis; Prusiner proved it. Gajdusek was grievously offended by Prusiner’s Nobel, perceiving his rival – not inaccurately – as a follower who never originated any ideas of his own. But Gajdusek was offended from a federal prison cell, so how’d that work out for him? Fascinating as all this is, no one published a book about prions in the mid-2000s because it was about kuru or FFI. They published books about prions because teenagers were dying, and people wanted to know why. DTM lays the seeds for part 3 – the mad cow section – in part 1. This is a discussion of scrapie, the longstanding prion disease of sheep. Scrapie was a medical mystery for centuries (remember poor D. R. Wilson), precisely because of the intuitive implausibility of prions. The scrapie chapter is a great history-of-science piece, covering the agricultural productivity revolutions of the 18th century, the surfeit of bizarre origins veterinarians concocted, and the treatments that never worked. Scrapie is not transmissible to humans – well, we hope. It’s concerningly transmissible to primates. But it’s been around for a long, long time, and it doesn’t epidemiologically look like humans get it...we hope. Anyway, you ever tried to generalize from one example? The British government did! In the mid-1980s, strange reports started coming out of the UK’s farms. Farmers were describing a new disease where dairy cows – incredibly docile creatures, under normal circumstances – turned hostile, kicking them as they went into the milking stalls. The symptoms looked to all the world like scrapie. Epidemiologists tracing the outbreaks found a unifying link with “cake” – animal protein feed sweetened with molasses. The scrapie-like symptoms must have traced to an infected sheep. But scrapie doesn’t transmit to humans, so it must be okay to keep slaughtering them, right? We all know how this ended. The best term for the British response to the mad cow outbreak is “cacklingly evil conspiracy”. The agricultural industry really, really didn’t need a huge zoonotic outbreak – so it decided it didn’t have one. They first suppressed all mentions that the disease looked like scrapie, then – when this became impossible – hyped up that scrapie doesn’t transmit to humans, so there’s nothing to worry about. The formal name of the disease, “bovine spongiform encephalopathy”, was supposedly chosen to optimize for unfamiliarity – it wouldn’t fit well in a headline. They emphasized, extensively, that there was nothing to worry about. Ever. At some point, people started asking questions. If there was nothing to worry about, why was the agricultural industry panicking so hard? As things became ever more worry-inducing, this turned down ludicrously twisting paths: Meanwhile, the Southwood Working Party and the experts who advised it were learning on the job. They learned, for instance, that the BSE agent entered the animal through the mouth and then followed the digestive tract into the organs that try to filter out infections—the tonsils, the guts, and the spleen—and from there traveled into the peripheral and central nervous system, and finally arrived at the brain. They also learned that pasties, meat pies, and even some baby foods contained tissues from a lot of those organs. So the Southwood Working Party recommended banning these organs, but only from baby food. This started a chain reaction of consumer doubt: if infected cow organs were unsafe for babies, how could they be good for adults? The government then banned offal, as the organs were collectively called, in all human food but gave the industry a grace period to get it out of the feed supply. Then pet food manufacturers began to wonder if what drove cows mad might not also drive dogs, cats, and parrots mad. The feed they sold came from concentrate made of the same sick animals that had previously made up the meat and bone meal farmers used. Their trade group decided to put a similar ban in place—immediately. So for five months it was safer to be a dog than a human in Britain. DTM spends pretty much this whole section of the book making fun of the British government. To be fair, they deserved it. They killed hundreds of kids in agonizing and preventable ways – they could take some ribbing. This is all throughout the mid-1980s to early-mid 1990s. Through this period, it wasn’t yet clear that mad cow could spread to humans. The panic was clear, and deserved, but it didn’t yet have a match for its powder keg. It would alight. The first suspected case of vCJD – human mad cow – was in 1994. Fifteen-year-old Vicky Rimmer developed a sudden, strange disease. Doctors gave her months to live...until she died in 1998. A couple other suspected cases trickled down through the mid-90s, including a young man who made meat pies for a living, whose grieving mother received a letter from the Prime Minister that “humans do NOT get mad cow disease”. (That must’ve been fun.) Soon, they couldn’t deny it any longer. On March 20, 1996, Stephen Dorrell, the health secretary, stood up in Parliament to announce the news that had already appeared as a tentative conclusion in scientific journals and as rumor in newspapers for the previous two years: British beef was killing British teenagers. The first confirmed death was that of Stephen Churchill, a nineteen-year-old student from Wiltshire, who died in May 1995. Back in 1989, at the Southwood Working Party’s suggestion, the government had set up a surveillance unit in Edinburgh to watch for any evidence that BSE had crossed to humans. One worry had been that if BSE passed to humans, how would anyone know it? How would you recognize something you had never seen? It turned out to be easy: Churchill and the nine other teenagers who had gotten sick had spectacular amyloid plaques in their brains, chunks of dead protein almost visible to the naked eye. If sporadic CJD was a whisper, BSE-caused prion disease was a shout. The investigators sat open-mouthed looking at slides whose damage, they feared, portended the most severe epidemic in modern British history. This part of the book is not fun. It lacks the insane personalities and duelling careers of the other entries. It is an honest chronology of the vCJD epidemic – a gruesome failure of the agricultural industry, the one system that everyone is vulnerable to. The government and industry had completely violated their duty of care to citizens and consumers. They were paying the price. No one would buy British beef anymore – not while they watched their children die. Now here’s the thing: this is ethnography, not historiography. The Family That Couldn’t Sleep is a book from the mid-2000s. The epidemic was not at all in the rear view mirror. There were piles of unanswered questions that DTM constantly alludes to. We have eighteen years more hindsight than he did then. What do we know now? --------------------------------------------------------- In 2006, the vCJD epidemic looked like it was going to be a lot better than the worst fears. BSE itself was a huge problem for the cattle industry, but honestly, no one is too sympathetic to the cattle industry. People were not going to die in anywhere near the numbers believed. We had all sorts of reassuring data coming out about this, which DTM chronicles. We were learning that only some genotypes seemed susceptible to vCJD. We didn’t see any older people die of the disease. We were seeing numbers drop, such that vCJD must have a pretty short incubation period. Anyway, all of this is wrong! The Family That Couldn’t Sleep was written in the candidate gene era. Back then, the nascent field of human genetics was sure it was about to Solve Polygenism. Yes, the simple Mendelian monogenic patterns popular a few decades back clearly didn’t apply to common diseases, but how many variants could there be? We were about to discover the five genes influencing 20% of Alzheimer’s risk each, the five genes influencing 20% of heart disease risk each, etc., and once we were done we’d just do gene therapy and cure Alzheimer’s. A paper on autism genetics from 1999 was so outre as to speculate there might be as many as fifteen genes involved. The fact we are now using the term “omnigenic model” should tell you roughly how well this worked out. Do you remember SNPedia? If you were a 2014 Slate Star Codex reader, you might. 2014 was still pretty candidate gene. People were out there publishing papers saying a single variant could increase your life expectancy by 15 years. SNPedia was a site that beautifully categorized all of these, so you could do 23andme or whatever, look up your results on SNPedia, and make horrible life choices.5 It was eventually bought out by one of the consumer DNA companies, so no one ever edited it again, making it a great time capsule of early-mid 2010s behavioural/medical genetics takes. SNPedia will excitedly explain to you that common genetic variants make you immune to vCJD. They cite a 2009 post from the now-archived 23andme blog titled “No Good Evidence That Potential Pool of Mad Cow Disease Victims Is Expanding”, explaining how fears of late-onset vCJD are clearly debunked by new Scientific Knowledge. Everyone who developed vCJD in the 1990s and 2000s had an M/M genotype in a particular part of the PRNP prion gene, so the roughly half the population with M/V or V/V genotypes were immune. The Family That Couldn’t Sleep buys this, too. In fact, it buys it in an even more agonizingly 2000s way. The first sign that transmissible prion diseases weren’t genotype-restricted should’ve been the growth hormone kids. You might have heard this story – from the late 1950s through mid-1980s, human growth hormone produced from brain tissue was used as a treatment for pituitary dwarfism, until it turned out to spread CJD if the originating brain was infected. DTM discusses this, to set the scene for the genetics thing. He mentions what was the state of the art at the time – that a disproportionate share of both the growth hormone kids and sporadic CJD cases were V/V homozygotes. This, uh – so the book was written in the mid-2000s, yeah? Yeah. The conclusion DTM drew – and this was a common conclusion at the time – was that homozygosity somehow made you more vulnerable to CJD, and M/M homozygosity made you vulnerable to BSE-borne CJD in particular. We cannot criticise the author for not predicting the future, but we live in the future, and can say how this worked out. Turns out, nope, M/V heterozygotes totally get vCJD. After a British man in his 30s died of CJD in 2016, he was found to have vCJD and an M/V genotype. He was tested for vCJD only because he was exceptionally young for someone with a sporadic prion disease – meaning people developing it later in life would be missed6. Did you know up to 1 in 2000 people in the UK have latent vCJD? There is one line in The Family That Couldn’t Sleep that stopped me dead in my tracks when I read it: What happens to the Italian family in the end depends less on their own actions than on the world’s interest in prion diseases, which they cannot control. If lots of people are afraid of getting variant CJD, the family benefits. If fear of prion disease goes the way of the fear of swine flu or Ebola, then they will be orphaned again. THIS BOOK IS FROM 2006! Three years before the swine flu pandemic! Eight years before the Ebola pandemic! “If you’re looking for a sign, this is it.” --------------------------------------------------------- The last section of The Family That Couldn’t Sleep addresses BSE fears in America and a nascent internet subculture DTM calls “Creutzfeldt Jakobins” – people who track American CJD cases, trying to spot vCJD patterns. When reading his description of the Creutzfeldt Jakobins, my mind constantly, uncontrollably turned to covid. Here it was – an online community of people deeply skeptical about a disease’s official story, tracking every contradiction, every implausibility, every statistic that failed to apply to the individual. Self-described “redneck hippies” and “soccer mom Republicans” teaming up to find the truth hidden behind an impossible world. You know what they’re doing now. I’ve always combined a deep interest in medicine with a healthy distrust for it. People who are constitutionally inquisitive, anti-authoritarian, and suspicious about official narratives tend to end up skeptical of at least some mainstream claims in the field. This is not to say I think you should take bleach enemas or something, just that I understand the impulse behind concluding the US government was covering up a local vCJD wave. Traditionally, sporadic prion diseases are said to have a prevalence of one in a million. (Hold on to that for a second.) The last section of the book is a chronology of Americans finding bizarrely more than one in a million of their friends dying of sporadic CJD, often at inexplicably young ages, sometimes in geographical clusters. This is understandably suspicious. Then DTM goes on to reassure us by saying none of these cases were confirmed to have an M/M genotype, which OH GOD OH FUCK A number of high-profile people in the prion world, including Gajdusek, are clarified as not believing sporadic prion diseases exist. You get the impression DTM doesn’t, either. Now, how common are prion diseases? Eric Vallabh Minikel has an answer for you! Eric and his wife Sonia are prion researchers from a rather unique background – after Sonia was diagnosed as having a single-gene mutation with ~100% penetrance for prion disease, they left their previous jobs to dedicate their lives to curing it. It turns out, when you run the numbers, you get not one in a million but 1 in 5000 people dying of prion diseases. This is best described as “nightmarishly high”. I’m normed on genetic disorders. A genetic disorder that affects one in five thousand people is pretty common! I have known, in person, completely unselected, just from “random people I’ve met in my life in a non-medical context”, someone with a ~1/250k syndrome and someone with a ~1/50k-100k syndrome. I don’t think anyone in my extended family knows someone who died of a prion disease. I feel like it would’ve come up if they did! Prion diseases have distinctive phenotypes. Not distinctive enough, apparently, to avoid a lot of CJD being misdiagnosed as Alzheimer’s – but diagnosis is consistently insane. Something DTM reiterates throughout The Family That Couldn’t Sleep is just what prion dementia looks like. The characteristic dementia in prion diseases spares something – “self” or “recognition” or “reflection” – that is not spared by Alzheimer’s, or by most common dementias. Shouldn’t this be, uh, noticeable?7 They kill rapidly, often over the course of months, and often onset in midlife. ALS shares this pattern and is way, way more common than prion diseases; you hear about ALS far more in the “disorder people actually have” sense. What am I missing here? Anyway: 1 in 2000 prevalence of latent vCJD in the UK + extreme lack of clarity over whether scrapie is human-transmissible + blood donations spread vCJD + sporadic CJD prevalence keeps going up = ??? (Yes, I am annoyed that most countries have lifted their ban on UK blood donors, thank you for asking!) --------------------------------------------------------- But back to the book. The “American chapter” is one-third about the country’s response to vCJD, one-third about the Creutzfeldt Jakobins, and one-third about chronic wasting disease. The last part is the most interesting. Chronic wasting disease is a prion disease of deer. Like scrapie, it “probably, we hope” isn’t human-transmissible (eat venison at your own risk). Under natural circumstances, deer shouldn’t get prion diseases: A prion plague should not be possible among ruminants in the wild. Deer are not cannibals, as the cows that spread BSE were forced to be; and, because deer and elk are not domesticated, they do not have enough contact with one another to spread a prion infection the way sheep are thought to spread scrapie. But deer do not live as they used to live, humans having once again brought their ambitions to bear on the natural course of things. The Family That Couldn’t Sleep is a book of medical anthropology. Anthropology of the Veneto, anthropology of Papua New Guinea, anthropology of 1990s Britain. Here, it is an anthropology of America. Americans, having won the world, still fight to win their own backyard. The North American continent is geographically diverse, cutting through rain-snow-shine, mountains jutting over plains, cities sprawling into wilderness, habitations criss-cross dotted with surprisingly few empty zones. Go somewhere like Denver, the Mile High City, three million people fighting against nature. Few other countries have anything like this; geographically vast polities usually have uninhabitable blocks. Australians are twenty-five million people clustered against the shore. It still surprises me, after all this time, how every US state has a meaningful city8. Midcentury Denver, growing and sprawling out across its mountains, started to run into their natural inhabitants – deer. Starvation is one way nature adjusts the deer population to the available food supply. People did not usually see this process, but in the 1950s and 1960s Colorado became more densely settled, reducing forested areas and forcing deer to look longer and harder for food. At the same time, the state enacted conservation laws, limiting when and where hunters could shoot. Soon emaciated deer began wandering onto the lawns and through suburban streets looking for a meal. People began to feed them, only to find that they died anyway. They would drop dead by haystacks, along highways, and in flower beds. In the late 1960s, a young biologist named Gene Schoonveld tried to figure out why the deer starved even when they were fed.9 He deprived some deer of food for a while, “[h]e cut windows in their stomachs to see what went on inside, and then he began to feed them”. While this was going on, he had a control group of healthy, well-fed deer as backups in case anything went wrong. It did...but not to the experimental group. The pen in which the deer were kept also housed sheep, which, it turned out, were scrapie carriers. The deer somehow acquired scrapie – there’s a huge unanswered question here, which DTM doesn’t address. How did they get scrapie? They didn’t eat the sheep, presumably. Did it somehow transmit from casual contact? This is not supposed to happen. And yet: the deer in the sheep pen started dying of a mysterious scrapie-like disease, one never reported before, that would go on to infect thousands. These deer were released into the wild. Ten years later, the first reports of chronic wasting disease came out. The disease spread across deer and elk in the western half of the country. By the turn of the millennium, cases were exploding – and lost all geographical restriction. DTM can report up to 2005, at which point it was floating around Upstate New York. This kind of spread doesn’t track natural deer migration. That’s irrelevant, because nothing about CWD’s spread is natural. We shift gears into an anthropology of the American hunter. The hunter wants to shoot the most impressive buck, to bag himself one with as many “points” as possible – one whose antlers branch out most. A “ten-point buck” has five branches on each horn: Original by Ric McArthur Nature doesn’t make enough bucks with perfectly symmetrical ten-point horns. To fill the demand, the market had to step in. Thus was born the deer farm industry, which raises captive deer in better genetic and nutritional conditions than Nature permits, then ships them across the country so hunters who couldn’t get legit ten-point bucks get the taxidermy piece for their wall. These are controversial amongst hunters and illegal in numerous states – but the industry is big enough to spread CWD. (The kind of hunter who needs a deer shipped to his house is the kind of hunter who will fumble killing it.) Another problem is supplemental feeding – leaving out protein-enriched food for deer to eat. This produces “trophy class animals at an earlier age”, but again, what’s in that protein? (“It is much like feeding your cows 41 percent protein cottonseed cake during the winter to raise the protein level in the cow’s diet to a level that will maintain acceptable production”, says that article from 1991.)10 The book segues into a vignette. CWD was new in Wisconsin in the early 2000s, and the state’s Department of Natural Resources was optimistic it could eradicate it. In a state with a love of hunting, you could, in theory, recruit people to kill every single deer in a 400-square-mile radius: In many states, the state would have had to call out the National Guard for such an onslaught, but hunting is a passion in Wisconsin. Hunters shoot 450,000 deer every year, more than in any other state. “I’m looking for ardent hunters to help us, unless fear or their wives keep them away,” one DNR official told a Milwaukee magazine. The state extended the normal hunting season and waived the usual limit of one buck per hunter, and the hunters came out in force. The whole affair was gruesome – one official called it “hunting for slob hunters”. If you’re trying to eradicate a prion disease, you can’t very well let people take the carcasses home to eat. Bodies piled up in control stations, decomposition mingling with bleach. The 2002 hunt established a base rate of 2% for chronic wasting disease in Wisconsin deer, with the most affected areas getting up to 10%. Further hunts in 2003, 2004, and 2005 spread to wider and wider areas – and didn’t move the needle one bit. This is to say that CWD is quite a bit more common in the American deer population than BSE ever was in British cattle. Since publication, it’s popped up in Norway and South Korea. Notably, Norway doesn’t allow for the import of cervids, raising numerous questions about how it got there. There are no unambiguous cases of CWD transmission to humans, and in vivo/in vitro primate studies have mixed results. There sure are some unusually young hunters with sporadic CJD, though. But don’t worry, most of them aren’t M/M homozygotes! There is an absolute ton going on in this book. I’ve had to skim over whole sections. Parts that couldn’t be easily slotted into a narrative review include: When Gajdusek was invited to a party at Prusiner’s house, he was horrified to find his rival had purchased hundreds of New Guinean statues – all with the genitals removed.
August 22, 2024 · Original source
This is still a mystery to me. The compounding pharmacies are circumventing the patent, so they don’t need to pay back investment. And there’s a lot of competition between various compounders and telemedicine startups - even 23andMe is getting in on the deal now! And some Harvard doctors recently published a paper saying that the unit cost to the manufacturer is only about $5/month.
October 17, 2024 · Original source
Suppose we truly understood both of these factors. You could send your genes to 23andMe and receive a perfectly-accurate estimate of your weightlifting potential. And scientists had long since discovered the perfect training regimen (including the perfect training regimen for people with your exact genes/lifestyle/limitations). Then you could plug your genotype and training regimen into a computer and get the exact amount you’d be able to lift after one year, two years, etc. The computer is never wrong. Would weightlifting really be a sport anymore? A few people whose genes put them in the 99.999th percentile for potential would compete to see who could follow the training regimen most perfectly. One of them would miss a session for their mother’s funeral and drop out of the running; the other guy would win gold at whatever passed for this society’s Olympics. Doesn’t sound too exciting.
July 03, 2025 · Original source
You mention epidemiologists being the biggest losers of stratification in polygenic scores, but I think it is important to note a related group: the people who take polygenic scores trained in one population (with a ton of stratification) and directly apply them to other populations to make claims about innate abilities (see: this post). This is especially true for Edu/IQ GWAS, where every behavior geneticist has been screaming "do not do that!" since the very first study came out. People like Kirkegaard, Piffer, Lasker, etc. (and their boosters on social media like Steve Sailer and Cremieux) dedicated their careers to taking crappy GWAS data from and turning it into memes that show Africans on the bottom and Europeans on the top. These people also happen to be the court geneticists, so to speak, for SSC/ACX. I don't mean to come off as antagonistic and I'm sure some people will see this comment and immediately discount me as being an ideologue/Lysenkoist/etc so it does my broader position no favors, but this stuff has done and continues to do an enormous amount of damage to the field (including the now complete unwillingness of public companies like 23andme to collaborate on studies of sensitive traits
July 31, 2025 · Original source
Last month, a startup called Nucleus took the plunge. They had previously offered 23andMe style genetic tests for adults. Now they announced a partnership with Genomic Prediction focusing on embryos. Although GP would continue to only test for health outcomes, you could forward the raw data from GP to Nucleus, and Nucleus would predict extra traits, including height, BMI, eye color, hair color, ADHD, IQ, and even handedness.
December 10, 2025 · Original source
The other good news is that somehow they don’t charge a subscription, which makes them a way to get usually-subscription-only AI models for free. How is this possible? “[The most likely hypothesis is that] Witpaw is an adorable piece of spyware and he’s selling my data to the CCP”. 36: This month’s anti-people-named-Sacks content: NYT on Trump AI czar David Sacks’ conflicts of interest; New Yorker on whether neurologist Oliver Sacks used his case studies to work through his own issues rather than presenting them accurately. [EDITED TO ADD: I originally framed it this way as a joke, but on further research I think David and Oliver are related. Wikipedia says that Oliver was first cousins with Israel statesman Abba Eban, and that Abba Eban was born to Lithuanian Jewish parents in Cape Town. David Sacks’ bio says he was born to Jewish parents in Cape Town, and this article specifies that they were Lithuanian. I doubt there were too many Lithuanian Jewish families named Sacks in mid-1900s Cape Town, so sure, related!) 37: Orca Sciences: There Has To Be A Better Way To Make Titanium. Titanium is a great metal - strong, light, and tough. If we had cheap titanium, it could revolutionize manufacturing the way cheap steel and aluminum did in previous eras. So why don’t we? Not because titanium is rare: it’s “the 9th most common element in the earth’s crust”. Rather, it’s very complicated and expensive to extract from its ore. Some kind of breakthrough in titanium extraction processes always seems tantalizingly close, but has never quite materialized. Is there any hope? 38: If Asians Are Lactose Intolerant, Why All The Milk Tea? Lactose intolerance has confused me for a long time - 23andMe tells me that I’m lactose intolerant, but I drink milk regularly without problems, so what’s up? This post’s answer: lactose-intolerant people who don’t usually drink milk will get sick if they start suddenly. Lactose-intolerant people who drink milk regularly since childhood develop gut microbiota that can digest milk, but which demand an expensive “tax” in calories. Lactose-tolerant people will always be able to digest milk and absorb all the calories themselves. 39: How do different majors change college students’ political beliefs? No surprise that the humanities and social sciences shift people left; no surprise that business and economics shift them right. I was a little surprised that engineering shifts people right a little, and that Education of all things shifts people right (albeit only slightly). How is that even possible? Are these people coming in as Mao Zedong and leaving as “only” Leon Trotsky? Also, Political Science is exactly neutral, lol. [EDIT: I misunderstood, they’re using natural sciences as a zero point, this is a reasonable choice but slightly changes the interpretation] 40: Kindkristin: Language models improved my mental health. 41: More floor employment, from the WSJ (h/t @LaocoonofTroy): Big Paychecks Can’t Woo Enough Sailors For America’s Commercial Fleet: “Straight out of college, graduates from the country’s maritime academies can earn more than $200,000 as a commercial sailor, with free food and private accommodations... Despite the pay and perks, maritime jobs go begging, and it is raising national-security concerns.” Other selling points include “six months vacation, live wherever you want, and you’re serving the nation” and onboard “gyms, connectivity, and cuisine”. The catch is that you have to be at sea for months at a time. 42: Study (h/t @KierkegaardEmil): there was minimal “learning loss” from COVID school closures, best estimate is “0.02 standard deviations per 100 days of school closure”. I correctly predicted this back in 2021, but I also wrote in March of this year about how there’s been a general decline in NAEP scores since then. It seems like maybe a student having their specific school closed for longer than other schools didn’t hurt them, but some sort of general cultural change, maybe related to COVID, did hurt. 43: Sam Bankman-Fried’s mother on why she thinks his trial was unfair. SBF is appealing his conviction and will probably be making some of these same points in court. Can’t find a prediction market directly on the appeal, but this one says only 15% chance he serves under 10 years, this one says 15% chance of a Trump pardon, so it doesn’t seem like there’s much room for him to be freed (or get a significantly shorter sentence) on appeal. And Wired says that only 5-10% of appeals like these succeed. 44: Related: Trump pardons Juan Orlando Hernandez, former Honduran president extradited to the US for narco-corruption. Some sources are trying to find a Prospera angle - Prospera and other ZEDEs were approved under JOH’s administration, and the Prosperans seem to have good MAGAworld connections - but I don’t think this is their top priority, and I don’t know if it requires much explanation for Trump to be pro-right-wing Latin American politicians convicted by the Biden administration. More interesting is that apparently JOH and SBF were cellmates (X), “SBF spent extensive time helping JOH with trial prep” and SBF told an interviewer that “Juan Orlando is the most innocent prisoner I’ve met, myself included.” ChatGPT is not impressed with the Trump/SBF case for JOH’s innocence. Related: JOH’s conservative party on track to win this month’s extremely-close Honduran elections, great news for Prospera if it happens. 45: The “100 Above The Park” building in St Louis (h/t Bobby Fijan on X): 46: The death toll of the ongoing Sudan genocide has risen to about 150,000. Nicholas Kristof writes that the world has once again failed to prevent atrocities, and argues that the most important point of leverage is pressure on the United Arab Emirates, which is arming the genociders. Sam Kriss also writes about the situation in The World’s First Matcha Labubu Genocide, but is unimpressed with Kristof’s take: Sudan is passed over in a deeply uncomfortable silence. The absolute most you can do is blame the Emiratis. From what I’ve seen, more people seem to be appalled at the UAE for its frankly marginal role in arming the RSF than at the RSF itself. This is the approved way of understanding any inscrutably indigenous foreign conflict: you just worm out any third-party involvement and then act like you’ve solved the whole thing. I side with Kristof here, for reasons that Sam himself touches on later in his piece, in a section comparing Darfur with Gaza. It would be very easy to make people care about Darfur again. All it would take is a loud, vocal contingent of RSF apologists in the Western media. I agree, but would frame it less cynically: the reason Westerners pay attention to Gaza is that there’s a lever to push: not only does America support Israel, but many of their friends support Israel, so they can imagine convincing America or at least their friends to stop, and at least feel like there is some remote chance of making a small difference (and in fact, Trump getting mad at Israel and deciding to pressure them was decisive in effecting the cease-fire). On the other hand, we don’t have many levers to affect ethnic Baggara in the Rapid Support Forces of Sudan, so it doesn’t really feel useful to write blog posts arguing that they should stop; obviously they should stop, nobody disagrees with this, and it goes without saying - so nobody says it. But the US does support the UAE, and many of our friends like the UAE or at least go there on vacation, so maybe it’s possible to have make some small difference by embarrassing them. 4D chess take is that Sam Kriss agrees with all of this, but “loudly” and “vocally” argued against it to give people like me a hook to write about this genocide with, in which case I thank him for his sacrifice. It would also be nice to be able to donate, but I don’t know who to trust in the region - other than Doctors Without Borders, who are usually pretty good. 47: The AI Futures Project (group of AI-will-be-fast intellectuals) and the AI As A Normal Technology team (group of AI-will-be-slow intellectuals) wrote an adversarial collaboration in Asterisk explaining what they agree on, for example: That there’s an important distinction between existing AI and “strong AGI”
80,000 Hours

80,000 Hours is a recurring organization in the Astral Codex Ten archive, appearing 11 times across 11 issues between January 29, 2021 and January 21, 2026. The archive places it in contexts such as "It's an 80,000 Hours page saying that that it's important to protect the long-term future"; "Effective Altruism, per 80,000 Hours"; "As Joan Rohling details in an 80,000 Hours podcast". It most often appears alongside Twitter, EA, effective altruism.

Article page
80,000 Hours
Mention count
11
Issue count
11
First seen
January 29, 2021
Last seen
January 21, 2026
January 29, 2021 · Original source
Weyl's link doesn't support his claim. It's an 80,000 Hours page saying that that it's important to protect the long-term future, something EA has believed since the beginning. EA started with a sort of merger and cross-pollination between people trying to save lives by eg curing malaria, and transhumanist/singularitarian groups working on protecting the long-term future; it held together because both groups agree that the other's position can make sense given different sets of complicated assumptions about ethics and tractability. The page Weyl links highlights and explains the philosophy around that, but does not claim anyone had a sudden enlightenment where they realized they'd previously been ignoring the threat of totalitarianism and that was wrong. Everyone has always believed that stopping the rise of a totalitarian regime is one part of the important task of protecting the far-future, but we haven't focused on it because it's less tractable and less neglected than other parts. As far as I know we continue to think that and mostly not focus on it aside from occasionally looking for tractable interventions we've missed.
June 24, 2022 · Original source
A Russian sixth-grader could explain why celebrating the glories of Kievan Rus does not subvert Putin’s claims about the history of the Russian nation so much as reinforce them. Just like Hong Kong’s protests, Ukraine has won the meme war with utterly lopsided propaganda and unanimous international support on the Internet. As Yoshimi writes: Floating ghostlike above it is our war, the myth of the ‘Ghost of Kyiv’, ace MIG-29 pilot who has apparently shot down six Russian planes, or the legend of the Ukrainian soldiers defending an island outpost who replied “Russian warship go fuck yourselves” to a surrender offer and may or may not have died heroically, or two Russian II-76 transport aircraft that maybe were shot down near Kiev, or videos of air strikes or dead bodies which variously are Russian or Ukrainian until they turn out to be from Gaza six years ago, or the viral video of an old Ukrainian woman telling off a Russian soldier by offering him sunflower seeds so when he dies, sunflowers (Ukraine’s national flowers) will sprout from the soil. We’re raising funds for the Ukrainian army on crowdfunding apps and giving advice to the civilians being handed assault weapons about how to disable tanks, sharing weird homophobic pictures of Putin as a gay icon and spamming Russian government posts. Ukrainian president Volodymyr Zelensky has made the decision to stay and fight rather than flee like most would-be leaders who go all in for American foreign policy, and now is being deified by us as “badass”, “a true leader”, etc. etc., alongside his people, whose resistance to authoritarianism we are told is unparalleled in the modern world. After all, so it goes, who could be next? And like in Hong Kong, despite winning the culture war in hyperreality, the actual war in reality is won by the side with overwhelming military might, not morality. The real war is where Ukrainians are experiencing the genuine life-shattering effects of military conflict. It matters because this is the first time Western response is driven by Twitter outcry, and it will not be the last. A New EA Cause? Besides Hanania’s recommendations in the last section (which he admits are more or less impossible in an excellent interview with Caplan), a worthy EA priority might be to somehow turn the public tide on sanctions, which literally kill more people than Putin. Americans should be appalled by the atrocity committed in their names. The banality of the incompetence of foreign policy elites does not excuse their evil. With how entrenched the special interests are, I have no idea if it’s even worth trying, but at the very least the sheer amount of suffering and death from sanctions should be made common knowledge. Nuclear security is one of the top priorities in Effective Altruism, per 80,000 Hours, Future of Life Institute, and Our World In Data. Toby Orb, who wrote the definitive book on existential risk, The Precipice, estimates x-risk from nuclear war to be ~1 in 1000 in the next century. Luisa Rodriguez estimates a 1.1% chance of nuclear war each year and that the chances of a US-Russia nuclear war may be in the ballpark of 0.38% per year; summarised by Max Roser as: Nuclear risk is neglected by the public because of Pax Americana since the collapse of the USSR, and is not discussed as often in EA as it’s thought to be relatively well-funded and mainstream, but in fact major donors like the MacArthur Foundation have been withdrawing funding. As Joan Rohling details in an 80,000 Hours podcast there is much to be done, especially when Ukraine gave up their nuclear arsenal in 1994 in exchange for Russia’s promise to never threaten or use military force against them. A worthwhile adjacent cause area might be de-escalation of public outcry to reduce x-risk from nuclear war beyond just regular anti-proliferation efforts — even a Russian specialist from the RAND Corporation is surprised by how much public outrage is driving policy: Even just the pace of the sanctions: we went to 11 out of 10 in like two days — farther than many expected we’d ever get in short order. And I think the same is true about these military assistance initiatives. We’re just trying to do something because there’s a public demand for action. So that’s what worries me, that the sort of public outrage that’s being channeled in Western democracies through political systems could result in decisions that prove ultimately unwise. Despite how odd it is that some wars are “legal” while others aren’t, we should be glad UNSC exists as much as everyone laughs at how useless the rest of the UN is. All is fair in love and war, but international norms is all that stands between us and nuclear annihilation. It is hard to emphasise just how delusional it is for the public to fixate on no-fly zones — I, like Scott, am surprised we’re still capable of jingoism. 80,000 Hours has updated their top career recommendations to include China specialist to improve China-Western coordination on global catastrophic risk, which seems more important after reading how irrational and captured the American foreign policy apparatus is. As Hanania writes, “great power competition” is an anachronism. If Ukraine is the first war warped by hyperreality, it won’t be the last. Now that US foreign policy elites have driven Putin into the arms of China, let’s hope IR specialists can imbibe the public choice model instead of antagonising yet another nuclear rival. Public Choice Theory and the Illusion of Grand Strategy is an important work because it raises the sanity waterline, which at the least should make us stop killing millions for no reason, and at the most should make the human race more knowledgeable of how to prevent total extinction from nuclear armageddon. Pax Americana is dead, but a multipolar world will be more humane. Endnotes In the fiscal year 2018, the top five government contractors were all weapons manufacturers, with Lockheed Martin in first place at $40.6 billion. The Department of Defence spent $358 billion on contracting, ten times higher than second place Department of Energy. Collective action problems that stop a bunch of smaller companies from effectively influencing policy are no hindrance for companies like Lockheed Martin.
Nuclear risk is neglected by the public because of Pax Americana since the collapse of the USSR, and is not discussed as often in EA as it’s thought to be relatively well-funded and mainstream, but in fact major donors like the MacArthur Foundation have been withdrawing funding. As Joan Rohling details in an 80,000 Hours podcast there is much to be done, especially when Ukraine gave up their nuclear arsenal in 1994 in exchange for Russia’s promise to never threaten or use military force against them. A worthwhile adjacent cause area might be de-escalation of public outcry to reduce x-risk from nuclear war beyond just regular anti-proliferation efforts — even a Russian specialist from the RAND Corporation is surprised by how much public outrage is driving policy: Even just the pace of the sanctions: we went to 11 out of 10 in like two days — farther than many expected we’d ever get in short order. And I think the same is true about these military assistance initiatives. We’re just trying to do something because there’s a public demand for action. So that’s what worries me, that the sort of public outrage that’s being channeled in Western democracies through political systems could result in decisions that prove ultimately unwise. Despite how odd it is that some wars are “legal” while others aren’t, we should be glad UNSC exists as much as everyone laughs at how useless the rest of the UN is. All is fair in love and war, but international norms is all that stands between us and nuclear annihilation. It is hard to emphasise just how delusional it is for the public to fixate on no-fly zones — I, like Scott, am surprised we’re still capable of jingoism. 80,000 Hours has updated their top career recommendations to include China specialist to improve China-Western coordination on global catastrophic risk, which seems more important after reading how irrational and captured the American foreign policy apparatus is. As Hanania writes, “great power competition” is an anachronism. If Ukraine is the first war warped by hyperreality, it won’t be the last. Now that US foreign policy elites have driven Putin into the arms of China, let’s hope IR specialists can imbibe the public choice model instead of antagonising yet another nuclear rival. Public Choice Theory and the Illusion of Grand Strategy is an important work because it raises the sanity waterline, which at the least should make us stop killing millions for no reason, and at the most should make the human race more knowledgeable of how to prevent total extinction from nuclear armageddon. Pax Americana is dead, but a multipolar world will be more humane. Endnotes In the fiscal year 2018, the top five government contractors were all weapons manufacturers, with Lockheed Martin in first place at $40.6 billion. The Department of Defence spent $358 billion on contracting, ten times higher than second place Department of Energy. Collective action problems that stop a bunch of smaller companies from effectively influencing policy are no hindrance for companies like Lockheed Martin.
August 08, 2022 · Original source
As far as I know these people aren’t part of our conspiracy, and have reached this level of stylishness and correctness entirely on their own. (h/t 80,000 Hours) Or: what if we got the companies themselves on board? Big Pharma has a symbiotic relationship with the FDA; the biggest corporations hire lobbyists and giant legal departments, then use the government to crush less-savvy startup competitors. Regulations that boiled down to “only these three big tech companies can research AGI, and they have to do it really slowly and carefully” would satisfy the alignment community and delight the three big tech companies. As a sort-of-libertarian, I hate this; as a sort-of-utilitarian, if that’s what it takes then I will swallow my pride and go along.
But if this interests you, you can read 80,000 Hours’ Guide To Working In AI Policy And Strategy and maybe get involved. If you ever figure out the plan, let me know.
August 23, 2022 · Original source
You can read more about MacAskill’s justifications for each of those claims in the book. What careers does he suggest? Complicated question, but the best place to start looking would be the altruistic career counseling organization he co-founded, 80,000 Hours.
September 06, 2022 · Original source
35: This month in effective altruism: Vox Future Perfect is looking for more EA journalists. Charlie RS has a guide to How To Pursue A Career In Technical AI Alignment, and 80,000 Hours has updated their own page on same. I also liked Julian Hazell’s Why I View Effective Giving As Complementary To Direct Work.
October 25, 2022 · Original source
If you mean working for the cause: read 80,000 Hours and if appropriate apply for their career counseling. They reject many applications and nobody has a good idea for how to deal with this, sorry. They also have a Job Board.
November 28, 2023 · Original source
So my recommendation is that you look carefully into the research on what causes can most benefit the world - near-term, long-term, whatever seems most important to you after some honest study - and try to come up with some way to help them. If you want, take the Giving What We Can pledge to donate 10% of your income, or look at 80,000 Hours to see how you can get an altruistic career.
See here, Open Philanthropy is first-listed funder. Leader Kevin Esvelt has spoken at EA Global conferences and on 80,000 Hours
November 30, 2023 · Original source
Effective altruism is composed of lots of organizations like GiveWell and GivingWhatWeCan and 80,000 Hours and AI Impacts. Ask the question for each one of them:
Why do we need 80,000 Hours? To help people figure out what jobs have the highest positive impact on the world. Still no contradiction.
You could imagine a world where all these same organizations and people exist, but none of them used the label “effective altruism”. But it would be a weird world. All these groups support each other, always in spirit but sometimes also financially. Staff move from one to another. There are conferences where they all meet and talk about their common interest of promoting effective charitable work. What are you supposed to call the conference? The Conference For The Extensional Set Consisting Of GiveWell, GivingWhatWeCan, 80,000 Hours, AI Impacts, And A Few Dozen Other Groups We Won’t Bother Naming, But This Really Is An Extensional Definition, Trust Us?
September 04, 2025 · Original source
17: There’s a debate going on between philosophers and AI researchers over whether AI can be conscious. I find most of the discussion annoying - this is generally an area where we can’t know anything for sure, and both sides are mostly shouting their priors at each other. The only exception - the single piece of evidence I will accept as genuinely bearing on this problem - is that if you ask an AI whether it’s conscious, it will say no, but activating or suppressing deception-related features (sort of like a mechanistic-interpretability-based lie detection test) reveals that it thinks it’s lying when it says that! Link is to a Less Wrong comment from a researcher in the field; I look forward to seeing an eventual peer-reviewed paper. H/T JD Pressman. 18: 80,000 Hours has a high-production-value video about the AI 2027 scenario. 19: Dynomight vs. Casey Milkweed debate on mathematical forecasting, with special reference to AI 2027. And Dynomight comments on Casey’s post here. 20: The Psmiths review The Ancient City, about ways that ancient culture depended on family, clan, ritual, and “the household gods”. Sample quote: I'm more interested in what all this means for us today, because with the exception of maybe a few aristocratic families, this highly self-conscious effort to build familial culture and maintain familial distinctiveness is almost totally absent in the Western world. But it's not that hard! ... Perhaps this is why I have an instinctive negative reaction when I encounter married couples who don't share a name. I don't much care whether it's the wife who takes the husband's name or the husband who takes the wife's, or even both of them switching to something they just made up (yeah, I'm a lib). But it just seems obvious to me on a pre-rational level that a husband and a wife are a team of secret agents, a conspiracy of two against the world, the cofounders of a tiny nation, the leaders of an insurrection. Members of secret societies need codenames and special handshakes and passwords and stuff, keeping separate names feels like the opposite — a timorous refusal to go all-in. 21: Did you know: Epic Systems, the electronic medical record company, has a fantasy-themed corporate headquarters in Wisconsin, with buildings that look like castles, quaint medieval towns, and the Emerald City of Oz (h/t Devon Zuegel): Meanwhile, tech companies with ten times as much money pretend that they’re cool and playful when their HQ has some rounded edges and a set of colored cubes in front. Do better! 22: Effective altruists have been funding teams working on lab-grown meat for almost a decade now. Around 2020, they hired some experts to double-check that this was possible in principle, and the experts wrote scathing analyses saying it was cost-ineffective by so many orders of magnitude that it was basically a pipe dream. Reactions were mixed, but a lot of us beat ourselves up and vowed to be less gullible next time. But now a new report comes out arguing that the previous reports were wrong, that lab-grown meat production is going much better than the earlier reports thought possible, and it’s more or less cost-effective already for the simplest products! Again, mixed reactions, and although some of the numbers are indisputable the analysis itself this is by a VC firm with lab-based meat investments. Here are some related Metaculus questions. 23: Ozy, citing Stutzman et al: “Afghanistan after the American withdrawal has the lowest life satisfaction rate ever recorded. Two-thirds of respondents rate their life satisfaction below 2, which is generally considered to be the point at which a life is no longer worth living. Life satisfaction dropped significantly after the withdrawal of American troops. Women, people in rural areas, and the poor were particularly negatively affected.” 24: Lencapavir is dubbed a “miracle drug” for AIDS; a single dose protects against infection for six months. Unclear how this interacts with PEPFAR cuts; if PEPFAR still existed it would be a big boost to its efficacy; now maybe this might be part of a strategy to tread water? 25: Did you know: when people first started making artificial ice in the 1850s, there was a backlash from people who thought it was gross and dystopian and that people should insist on natural ice for their iceboxes. From Pessimists’ Archive, which goes on to draw an analogy to lab-grown meat, etc (h/t Isaac King on X). 26: From Peter Hague (on X) and commenter Phaethon: why did so many Anglosphere countries see immigration spikes in 2021? Each of these has their own local story. In Britain, it’s the paradoxical effects of Brexit. In the US, it’s Joe Biden being soft on immigration. And so on - but should we be looking for some deeper cause that explains the overall phenomenon? A commenter suggests “a way to soak up all the inflation from the COVID money printing”, but I can’t tell if that even makes sense. Still, should something something COVID be a leading hypothesis? 27: Jesse Singal vs. Mark Stern on the Skrmetti Supreme Court case that failed to overturn Tennessee’s ban on gender medicine. US law bans sex discrimination, so pro-transgender advocates argued that, since doctors often prescribe eg estrogen to biological women, it was sex discrimination to ban prescribing it to biological men. Tennessee’s anti-transgender argument was that they weren’t discriminating by sex, they were discriminating by diagnosis (estrogen for eg hot flashes, vs. estrogen for gender transition). There is some subtlety here (if a biological man grows breasts because of some hormone imbalance, doctors might give him testosterone to counteract it, and this seems sort of like giving biological women testosterone to make them look less like women), but these are still sort of different diagnoses (gynecomastia vs. gender dysphoria) and Tennessee said you can still think of it as diagnostic discrimination rather than sex discrimination. This makes sense, except that the standards around sex discrimination are very strict and sort of box the court in here. And in a fit of wokeness, the 2020 court (including some of the conservative justices hearing this case) applied these standards very strictly and ruled that discriminating against gays was a form of sex discrimination (since if women can date men, it’s sex discrimination if men can’t also date men), and this is obviously the same argument. Now that wokeness is less popular, the court wants to rule against transgender, but it can’t help tripping over its previous ruling and giving some kind of unprincipled confusing non-opinion. 28: Contra compelling anecdotes, only ~5% of people raised very religious end up atheist later in life (X). Most people are about as religious as their parents; most exceptions are only slightly less religious, and most families that secularize do it over several generations. Note: percentages are of total, not of each row! 29: Related: social science team proposes a three-stage model of secularization: decreased public ritual participation → decreased personal importance → decreased identification, presents apparently confirmatory data. If true, would be somewhat inconsistent with intellectual models (eg people learn about evolution and start doubting the Bible) and more consistent with institutional models (eg the government provides welfare so people no longer need to be part of a tight-knit church). 30: Navigating LLMs’ spiky intelligence profile is a constant source of delight; in any given area, it seems like almost a random draw whether they will be completely transformative or totally useless. Now Ethan Strauss reports that they are, for some reason, extraordinarily effective at teaching people golf. “I am predicting the Golf Revolution, or perhaps decline, if your perspective is that optimization tends to ruin hobbies. A sport for obsessives has been gifted the ideal tool for refinement.” 31: Claim (via nxthompson on X): “In a huge survey of young kids about phones and technology, they all say they want to be out playing in the real world. But parents don't let them out unsupervised. So they're stuck on their phones.” Interesting, but I’m nervous about social desirability bias - how many adults would say on a survey that they would rather be on their phones than playing with friends? But adults do have this choice and mostly go with the phones. 32: Steven Adler on AI psychosis. He tries to analyze ER admissions data for psychosis and finds no change. I don’t think anyone reasonable expected this to be a large enough effect to show up in ER admissions data, but there are lots of unreasonable people so I appreciate his effort. He thinks AI companies might have better data on this, and encourages them to release it. 33: Cuartetera was the greatest polo horse ever. Polo players responded in a very practical way: they cloned her, dozens of times (and it worked; the clones are also excellent). Now there is a lawsuit as different polo teams fight to get their hands on Cuartetera clones. What is the equilibrium? If the outsiders get their hands on the genetic material, do we see a world where every polo horse is a Cuartetera clone? How much is lost if nobody ever tries to breed a polo horse better than Cuartetera (since the economics might not check out if the odds of success for any given foal is too low)? H/T Gwern and Siberian Fox (on X). 34: Claim: as of 2013, India’s Agarwal caste, who make up less than 1% of the population, got 40% of the e-commerce funding. 35: Owlposting: What Happened To Pathology AI Companies? Pathology is a medical specialty. A typical task involves looking at a microscope slide full of cells and trying to determine if any of them are cancerous. This seems like a good match for AI - and for years, studies have been showing that in fact AI can equal human experts. So why isn’t it being used more? The author’s three answers: first, slide scanning is expensive and clunky, and you can’t apply AI to a slide until you digitize it. Second, it’s hard to figure out a business plan where this saves someone money and doesn’t step on the toes of big companies that can outcompete anyone they don’t like. Third, pathologists use the context of a patient’s entire clinical history when they interpret a slide, and AIs that can’t do that (either because of technical limitations or legal/privacy limitations) are at a disadvantage even if their skills specifically relating to slide-reading are better. 36: Noahpinion: Will Data Centers Crash The Economy? Suppose that AI is a bubble, either permanently (because the technology isn’t really transformative) or temporarily (because it can’t transform things quickly enough to keep up with all the dumb money pouring into it). Will the sudden write-off of data centers lead to a broader economic collapse? In 2001, the dot-com bubble harmed the tech sector, but didn’t take the rest of the economy down with it; in 2008, the subprime mortgage bubble did take the rest of the economy down with it, because it damaged banks that the whole economy relied on. The optimistic case for AI is that data center spending is mostly coming from big companies like Google and Meta that can absorb a lot of loss. The pessimistic case is that some of the money is coming from private credit, a new-ish form of finance which hasn’t really been stress-tested and whose failure modes are still poorly understood. Noah’s final verdict: the stage isn’t obviously set for a crisis yet, but there’s the potential to get there and we should consider acting (how?) early. 37: The latest Twitter talking point is that universal hepatitis B vaccination at birth is “woke”: Hep B is (aside from mother-to-child transmission) often sexually transmitted, slutty women’s children are more likely to have Hep B, so perhaps giving the vaccine to everyone (instead of testing and only giving to the children of women who test positive) is an attempt to spare slutty women the embarrassment of getting a positive test. Ruxandra Teslo provides the counterargument - Hep B tests take a while, the medical system is fragmented, and any attempt to test people and then give the vaccine inevitably leads to many positive tests falling through the cracks. Vaccinating at birth is easy and hard to screw up, the vaccine has no known side effects, and empirically child Hepatitis B rates go down (by as much as 2/3!) when countries switch from test-and-vaccinate to universal vaccination. This benefits everyone - even people who never have unprotected sex and always follow up on their medical tests - because toddlers in daycare exchange saliva copiously, and if your toddler exchanges saliva with a Hep B positive toddler they could get the disease. A funny Twitter interaction was seeing Republicans in Congress hop on the anti-slut anti-vaccination bandwagon - except for Senator Bill Cassidy (R-Louisiana), who happens to be a liver doctor, and who is still fighting the good fight. I am always nervous when a good person who I like starts engaging on Twitter, since it elevates the discourse there but also gradually turns their brain into mush - but Ruxandra has made the leap and is doing a great job not just on bio related topics but also (for example) countering Curtis Yarvin on the history of her native Romania. 38: The response to GPT-5 was confusing; most specific people who reviewed it said they were impressed (Ethan Mollick, Tyler Cowen, Nabeel Qureshi, Taelin), it performed as expected on formal benchmarks, but the overall vibes declared it a big failure. Peter Wildeford speculated that maybe there was some kind of sinister pay-to-play early access bias involved. Zvi went the other way, calling it a “reverse DeepSeek moment” (insofar as DeepSeek was a pretty average model that got glowing praise.) In the end, I agree with Peter that this was mostly a branding issue. o3 was a genuinely revolutionary model; if OpenAI had called it “GPT-5”, it would have met expectations. Instead, they called it “o3”, and called a minor incremental update a few months later “GPT-5”. Then people got mad that the exciting-sounding “GPT-5” was merely an incremental update. A secondary issue was that the router wasn’t very good, and so many queries got routed to a small version without thinking mode that was if anything a downgrade from o3. I think this tweet by Shakeel perfectly encapsulates the essence of GPT discourse in two sentences: …but maybe it’s worth asking why GPT-5 isn’t bigger than o3. Was 4.5 a failed attempt at scaling? Did it fail in a way that sort of back-handedly justifies the “lost steam” take? Does the answer depend on distinctions between pre-training scaling, post-training scaling, etc? How? 39: This month in etymology: did you know that “oy vey” is a “fully Germanic phrase” which is cognate with English “oh woe!” (h/t Wylfcen on X) 40: mRNA shows promise to be a game-changing treatment for cancer, but RFK is trying to halt research. But so far he can only starve it of money, not ban it, and the funding gap is only $500 million. Will there be enough philanthropic billionaires and private foundations to step up? Zvi points out that although there is usually a game of chicken where foundations are hesitant to touch something the government cancelled lest the government decide it can cancel everything and hope philanthropists pick up the bill, in this case there are no game theory considerations - RFK is halting it because he genuinely wants it halted, and they are thwarting him rather than playing into his hands. The only problem is that $500M is a lot of money for the private sector; a few foundations could technically afford it, but not many could afford it comfortably and still have money left over for the next few crises of this magnitude. I hope someone is trying to organize a coalition. 41: AI fantasy flash fiction Turing test. Eight stories about demons, four by famous fantasy authors, four by ChatGPT. After 3000 votes, AI wins: humans can't tell the difference and slightly prefer the AI stories. My own score was only 75%. But I will say that I thought Mark Lawrence's was obviously the best, I was ~100% sure it was human, and it convinced me that regardless of the official results it's still possible to write flash fiction that an AI obviously can't do. 42: “SignPro” offers customized “In This House We Believe” signs, try not to use this for evil. 43: China think tank assessment of how in control Xi is: still very in control, maybe not infinitely in control. 44: Related - did you know (h/t xlr8harder) that if you ask AI to write a science fiction story, it will very often name the protagonist “Elara Voss” (or some very close variant like Elena Voss), and this remains true across various models and versions? Related: Chelsea Voss of OpenAI is having a baby and has the opportunity to do the funniest thing. 45: “Hector (cloud) is a cumulonimbus thundercloud cluster that forms regularly nearly every afternoon on the Tiwi Islands in the Northern Territory of Australia…[he is sometimes called] Hector the Convector”. 46: British allergy sufferers who want to know the ingredients of things demand that British cosmetics stop listing their ingredients in Latin. “For example, sweet almond oil is Prunus Amygdalus Dulcis, peanut oil is Arachis Hypogaea, and wheat germ extract is Triticum Vulgare.” 47: Text-based RPG about being an NYT journalist at the Manifest prediction market conference. I make a brief appearance. 48: Study uses supposedly-random variation in doctor assignments to test whether the marginal mental health commitment is good or bad for patients, finds that it is quite bad. Freddie de Boer is violently skeptical (maybe literally so?) and makes some good points about how a single quasi-experimental study is never absolute proof. But I don’t think he quite justifies his opinion that the paper was irresponsible and should never have been published; it’s just a normal quasi-experimental study that we should nod and say “huh” at but not overweight as the culmination of all possible research that overcomes all possible priors. My prior is that the marginal commitment is pretty useless (many commitments are just “well, since this person arrived at our ED for some reason, it would look bad from a medico-legal perspective to just let them go, so let’s keep them a few days to evaluate” - and yeah, you should be upset about this) but I’m still surprised by how many outright negative (as opposed to zero) effects the researchers found. The strongest argument for negative effects is that it will make some people miss work and maybe lose their job. But this study found that commitment ~doubles the risk of near-term suicide (admittedly only from 1% to 2%), which would have been outside my confidence intervals for how bad it could be. I suspect confounding, but only on general principle, and I wouldn’t be too surprised either way. 49: This tweet is probably bait, but I found it a thought-provoking question: I think there’s a boring answer, where the law is more complex than just a single number and whatever kind of weird trafficking Epstein was doing is worse than whatever normal relationships these European laws are permitting. But assuming that there’s a substantive difference even after taking that into account, I think my answer is something like - we’ve got to divide kids from adults at some age, there’s a range of reasonable possible ages, we shouldn’t be too mad at other societies that choose different dividing lines within that range - but having decided upon the age, we’ve got to stick with it and take it seriously (in the sense of penalizing/shaming people who break it). This is more culturally relativist than I expected to find myself being, so good job to Richard for highlighting the apparent paradox. 50: Dilan Esper describes his experience as one of Hulk Hogan’s attorneys in the Gawker lawsuit (X). Parts I found interesting: none of the lawyers knew Thiel was funding the lawsuit; Gawker probably could have won if they had been slightly competent but kept "shooting themselves in the foot"; and Gawker probably could have won if they had just pixelated the private parts in the video. 51: Amazing concept and poems (link on X): I tried to see if AI could do this, and it did something that technically met the requirements but had zero artistic merit - using a lot of words like “nowhere” and “outside” in one, then separating them out to “no where” and “out side” in the other. I didn’t invest much energy in creating a clever prompt telling it not to do that, so feel free to report if you get better success. 52: New study claims consultants are actually good, at least for profits: "We find positive effects on labor productivity of 3.6% over five years, driven by modest employment reductions alongside stable or growing revenue" 53: A Polish team tries to test Peter Turchin’s equations for predicting political unrest on recent Polish history, has to make some changes but claims mostly positive results. 54: New big multi-author Substack, The Argument, trying to be a sort of center-left version of the model pioneered by The Free Press and other high-production-value ideological Substack properties. Excited to see Kelsey Piper is involved, and she starts off strong with a post on the latest round of First World basic income studies, which find few positive effects. This is surprising, because recipients didn’t waste the money on alcohol or gambling or anything - they paid down debt and got useful goods. Still, it didn’t even affect things that should have been obvious, like stress level. It’s not even clear that amounts of money large enough to help with rent made homeless people more likely to get houses! Matt Bruenig criticizes the article, accusing Kelsey’s studies of being downstream of Perry Preschool style dreams that exactly the right welfare program will have massively compounding effects that cut poverty out at the root and turn everyone into elite human capital; he thinks giving people money won’t do this, but it will increase equality and give the poor better lives. I assume he’s not a strong hereditarian, but his argument makes even more sense from that perspective, and I’ve certainly criticized dumb outcome measures like infant brain waves which we have only tenuous reasons to think are related to anything we care about. But Kelsey reasonably responds that the outcome measures she’s talking about include stress level and life satisfaction. To defuse this critique, Bruenig either has to argue that our construct “life satisfaction” doesn’t really measure whether someone’s life is satisfactory, or else claim that giving poor people satisfactory lives isn’t really what we’re going for - which I think would require more explanation on his part. There’s some further (impressively acrimonious) debate on X, but I don’t see anything that addresses my core concern. GiveDirectly, a charity involved in basic income experiments, has a presponse here; they say that some studies are positive, and that the ones that aren’t might have tried too little cash to matter, or been confounded by COVID making everything worse. They also point out that basic income is harder to study than traditional programs like giving people housing, because if you’re giving housing you can measure housing-related outcomes directly and have a pretty good chance of getting enough statistical power to find them, but since everyone spends cash on different things, the positive effects might be scattered across many different outcomes (and therefore too small to reach significance on each). Everyone involved in this debate wants to emphasize that the poor results are for First World studies only, and that studies continue to show large benefits to giving cash in the developing world. 55: Related: I was less impressed by The Argument’s first foray into housing policy, which follows an all-too-familiar pattern: Some people say they don’t like noise and disorder and try to make rules against it in their apartments.
56: People often ask me what potential careers will have the best chances if AI starts taking jobs. I have no idea, but 80,000 Hours - an organization very much at the intersection of career counseling and AI futurology - has written their own essay on How Not To Lose Your Job To AI - The Skills AI Will Make More Valuable, although it stops short of recommending specific careers by name.
October 17, 2025 · Original source
Miniatur Wunderland, reviewed by Laura González Salmerón. Laura works on the advising team at 80,000 Hours. The world is racing towards transformative AI without much of a plan: apply to speak with the team if you want to use your career to do something about it. Outside work, she’s chipping away at a PhD on representations of science in fiction. She’s using this contest as an excuse to launch a Substack she’s been meaning to start for years, The Turing Text (we’ll see how long it lasts). Blogging about literature, linguistics, and AI seems like productive thesis procrastination.
January 21, 2026 · Original source
80,000 Hours: 55
1DaySooner

1DaySooner is a recurring organization in the Astral Codex Ten archive, appearing 10 times across 10 issues between September 02, 2021 and June 18, 2025. The archive places it in contexts such as ""1DaySooner: FAQ: Long-Term Effects of COVID-19""; "1DaySooner and Rethink Priorities , $17,500, to research public attitudes around human challenge trials"; "emails to ... 1DaySooner bounced". It most often appears alongside ACX, ACX Grants, Australia.

Article page
1DaySooner
Mention count
10
Issue count
10
First seen
September 02, 2021
Last seen
June 18, 2025
September 02, 2021 · Original source
1DaySooner: FAQ: Long-Term Effects of COVID-19
December 28, 2021 · Original source
1DaySooner and Rethink Priorities, $17,500, to research public attitudes around human challenge trials. Human challenge trials are studies where scientists deliberately try to infect volunteers with a disease to see if a treatment can prevent or cure it. They're much faster than waiting for people to get the disease naturally, and could have significantly shortened the wait for coronavirus vaccines. But they're controversial and nobody was able to get approval to do a challenge trial for COVID until 2021, which is why we had to wait so long for good treatment. Preliminary research suggests lots of people support these trials; I think building common knowledge of this is a first step towards making them available during future pandemics. Rethink Priorities is a respected effective altruist research organization. 1Day Sooner is a group lobbying for challenge trials. They’re currently seeking $10 million to use challenge studies to develop a universal coronavirus vaccine. Email josh@1daysooner.org if you can help
October 02, 2022 · Original source
1: I’m trying to collect information on how last year’s ACX Grants winners are doing. I should have emailed everyone involved a form, but I know that the emails to Michael Sklar and 1DaySooner bounced, and based on how few responses I’ve gotten I worry some others have as well. If this is you, please fill in this form by October 15. If you didn’t get an ACX Grant last year, no need to worry about this.
November 04, 2022 · Original source
14: Survey To Understand Public Attitudes Around Human Challenge Trials (5/10) 1DaySooner has developed their battery of questions and analysis pipeline. They just received IRB approval to conduct the full survey.
May 22, 2023 · Original source
1: ACX Grants update: 1DaySooner is surveying people who have been involved in conducting phase III clinical trials (eg doctor, nurse, statistician, recruitment coordinator) to get their opinion on human challenge trials. If you're in this category and willing to help, go to hctexpertopinion.com
October 27, 2023 · Original source
Josh Morrison of WaitlistZero (now of 1DaySooner), who encouraged me and gave me good advice.
February 10, 2024 · Original source
1DaySooner, $100,000, to advocate for a specialized pandemic response team at the FDA. Although I complain about how long it took the FDA to approve the COVID vaccine, everything is relative, and they were able to approve it much faster than their usual process. This exhausted employees and created a backlog of other non-COVID tasks, and might not be possible even for another pandemic, let alone normal operations. 1DaySooner wants the government to fund an effort to make the FDA capable of Operation Warp Speed-style efforts in more situations, and maybe apply its lessons to everyday decisions. You can read more about their work here and here, and donate here.
June 10, 2024 · Original source
1: A message from ACX Grantee 1DaySooner: California is considering a law to ban things that emit ozone. As unintentional collateral damage, this bill would ban far-UV light, a new disinfection technology that can potentially eliminate all indoor respiratory diseases, but which also creates trivial amounts of ozone. Far UV is almost ready for deployment, and could potentially save tens of thousands of lives yearly. 1DaySooner, a health-related charity, is trying to convince the California government to exempt it from this law, or at least to remember that it exists when writing the exact text of the bill. They are asking Californians to write to their representative about this. Representative Buffy Wicks is on a relevant committee, and support from her constituents (Berkeley, Richmond, and north Oakland) would be especially helpful. I’ve posted more information - including what you can say to your representative - as a comment below.
February 07, 2025 · Original source
1DaySooner is an ACX grantee organization that advocates for innovative health policies. They’ve helped me write a list of who some of these people are, and some of the policies they could consider.
Compensating Organ Donors / End Kidney Deaths Act: Both of us co-writing this piece (Scott Alexander of ACX, Josh Morrison of 1DaySooner) have donated kidneys. We’re proud of our decision, but it’s not enough - waiting for people like us has resulted in a kidney shortage that kills a thousand Americans per month. Everyone knows the solution - compensating organ donors - but there hasn’t been enough political will to overcome the “ick” factor and make it happen. O’Neill could change that. He’s been speaking out in favor of compensation since 2009. And the time is right: Representative Nicole Malliotakis has introduced a bipartisan bill to provide $50,000 in refundable tax credits for people who donate kidneys to strangers. This paper found that a similar policy could eventually net 11,500 extra donors per year - which, aside from saving 11,500 people from end-stage kidney disease, could save the government $1 billion. O’Neill could boost this bill by getting it into the Executive Budget released with the State of the Union.
Regulatory Reciprocity: I will keep this one in here until somebody does something about it. It’s the idea that Americans should be allowed to buy medical products if they’ve been approved by some trusted ally, like the European Union, possibly in exchange for the EU giving FDA-approved products the same deal in Europe. This has been amply championed by Alex Tabarrok and the Mercatus crowd for years, and is starting to make inroads in other countries. If full reciprocity is a step too far, 1DaySooner proposes Makary build off innovative pilot programs like Project Orbis, which enables concurrent submissions and reviews of oncology drugs by multiple regulatory agencies, and the CoGenT pilot, which does the same for cell and gene therapies.
June 18, 2025 · Original source
This is great and the paper is great, but is also a microcosm of what I find frustrating about grantmaking. Will this paper change anyone’s mind? Will it lead to human challenge trials being more likely to happen? I assume yes, because 1DaySooner have proven to be generally smart people who know what they’re doing, but it’s hard to measure effects even now when we know exactly what the end product was.
538

538 is a recurring organization in the Astral Codex Ten archive, appearing 8 times across 8 issues between April 19, 2021 and November 07, 2024. The archive places it in contexts such as "Running the exact degree to which Trump was outperforming his polls through 538's model"; "Biden approval rating (as per 538)"; "Nate Silver’s election forecasts at 538". It most often appears alongside PredictIt, Trump, Twitter.

Article page
538
Mention count
8
Issue count
8
First seen
April 19, 2021
Last seen
November 07, 2024
April 19, 2021 · Original source
- On Election Night 2020, after Trump started outperforming his polls, shares in Trump winning briefly reached 70 - 80%. Running the exact degree to which Trump was outperforming his polls through 538's model, I determined there was still only about a 20 - 30% chance he would win. I had originally planned to see how much I could make off my original investment alone, but this seemed so much like free money that I took out my credit card and put a few thousand more dollars on Biden. I won about $2000 off this. I can't count it in my official score because it wasn't part of the original investment, but I would have been really angry at myself if I hadn't done this.
April 26, 2021 · Original source
US/WORLD 1. Biden approval rating (as per 538) is greater than 50%: 80% 2. Court packing is clearly going to happen (new justices don't have to be appointed by end of year): 5% 3. Yang is New York mayor: 80% 4. Newsom recalled as CA governor: 5% 5. At least $250 million in damage from BLM protests this year: 30% 6. Significant capital gains tax hike (above 30% for highest bracket): 20% 7. Trump is allowed back on Twitter: 20% 8. Tokyo Olympics happen on schedule: 70% 9. Major flare-up (significantly worse than anything in past 5 years) in Russia/Ukraine war: 20% 10. Major flare-up (significantly worse than anything in past 10 years) in Israel/Palestine conflict: 5% 11. Major flare-up (significantly worse than anything in past 50 years) in China/Taiwan conflict: 5% 12. Netanyahu is still Israeli PM: 40% 13. Prospera has at least 1000 residents: 30%
January 24, 2022 · Original source
1. Biden approval rating (as per 538) is greater than fifty percent: 80% 2. Court packing is clearly going to happen (new justices don't have to be appointed by end of year): 5% 3. Yang is New York mayor: 80% 4. Newsom recalled as CA governor: 5% 5. At least $250 million in damage from BLM protests this year: 30% 6. Significant capital gains tax hike (above 30% for highest bracket): 20% 7. Trump is allowed back on Twitter: 20% 8. Tokyo Olympics happen on schedule: 70% 9. Major flare-up (significantly worse than anything in past 5 years) in Russia/Ukraine war: 20% 10. Major flare-up (significantly worse than anything in past 10 years) in Israel/Palestine conflict: 5% 11. Major flare-up (significantly worse than anything in past 50 years) in China/Taiwan conflict: 5% 12. Netanyahu is still Israeli PM: 40% 13. Prospera has at least 1000 residents: 30%
February 03, 2022 · Original source
#29: Present An Open-Source Python Library For Monte Carlo Techniques At the heart of all serious forecasting is a statistical tool known as Monte Carlo analysis. It allows you to quantify uncertainty by introducing randomness to the inputs of computational models and looking at the range of results. If you want a good example, you might recognize Monte Carlo techniques from Nate Silver’s election forecasts at 538. It's been a gold-standard throughout my career in the space industry, and I can attest to how powerful it is - I've used it to successfully send a rocket to Mars. However, there aren't any tools out there that make it easy for researchers to take their existing models and wrap a Monte Carlo around it. So, I wrote one. It's an open-source python library which I'm calling "monaco". I'm at a point in development where the basic feature set is complete and working well, and I'm looking to finish up the extended roadmap in the next few months. See the project github page for the code, examples, and a lot more info: https://github.com/scottshambaugh/monaco. I’m looking for $1000 to help me present version 1.0 of this tool to the scientific community at the 2022 SciPy Conference in Austin, TX this summer. That amount should cover conference fees, hotel, and airfare, and if you're feeling generous I could use additional funds for some external monitors and cloud compute time. My name is Scott Shambaugh, and if you’re interested in helping fund this please email me at wsshambaugh AT gmail.com. Thank you!
August 01, 2022 · Original source
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August 16, 2022 · Original source
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November 21, 2022 · Original source
Polymarket again within 2% of Manifold. Only 23 traders here, and they’re a lot less optimistic than the Trump traders. FTX! 43 traders, seems like probably. I’ve seen a lot of Twitter takes about how rich well-connected people never get in trouble for this kind of thing, but the markets seem less cynical. 251 traders, and by the way amazing job by “mr22” who started this market on October 5. I also appreciate the relatively late end date - there’s another market “. . . by 2024” which is in the 30s, but that’s because people don’t trust the justice system to move quickly, not because they think he’ll be found innocent. There are a series of markets on sentence length which seem to suggest more than a month but less than a year in jail; this doesn’t really make sense to me and I’m going to nervously ignore them. Only 8 traders here, so take with a grain of salt, but this is a great example of the creative ways people are using Manifold. The market resolves not to “yes” or “no” but to the percent of FTX US users’ funds that they eventually get back; you make money if you were closer than other traders. Here they seem to think most people will only be getting about 14 cents on the dollar. There’s another market for FTX.US users which is a little higher at 29. 34 traders. I think this is too high; I bet it was some random third-tier insider, just because there are more of them and they’re under less scrutiny. Moving on to the effects on effective altruism in particular (just assume I have all possible conflicts of interest here): 272 traders, check the detailed resolution criteria. I think the strongest case is something like the one described in this article, about Center for Effective Altruism leaders discussing concerns about Alameda Research in 2018. The article doesn’t give specifics but my guess is they were the same issues Kerry Vaughn describes here (though see the followup comment by an employee who left FTX, casting doubt on Vaughn’s claims). That means the market hinges on whether Vaughn’s allegations fit the resolution criteria that “the unethical behavior must have been related to fraudulent investment strategies that involve spending other people's money without their permission”. Vaughn describes “poor capital controls, including a lack of distinction between money owned by investors and money owned by Alameda itself”, which sounds like it’s in that direction but could cover a wide variety of badness levels. My guess is everyone will end up agreeing that disgruntled Alameda employees whisper-networked that some things were bad about the company in 2018, some of the rumors got to CEA leaders, the leaders debated whether this was worse than normal for a tech startup, decided it didn’t rise to a level where they needed to publicly freak out, and moved on. Isaac will have to pay attention to the details as they come out and decide whether or not it qualifies. 45 traders. This seems to confirm that the CEA incident is responsible for most of the probability mass above; many fewer people think the FTX Future Fund (ie the charitable branch of FTX responsible for giving out their money) was in on this. Related: this market only has five traders, but I’m highlighting it anyway in the hopes that it gets more. The most money is on 2022. My guess is that we’ll find that they had terrible accounting practices in 2018-2019 of the sort that could be classified as criminally incompetent in a way that bled into fraud (but the trades went fine so nobody was harmed) and then they ramped it up a lot in 2022 to deal with the crypto crash. I think this market will be harder to resolve than people expect. 47 traders. Everyone is panicking about this possibility, but it looks like it’s not too likely. 10 traders. I’ll take this chance to say: a lot of media is predicting the death of EA, or a major blow to EA, or something in that category. Not going to happen. The media isn’t good at understanding people who do things for reasons other than PR. But most EAs really believe. Like, really believe. If every single other effective altruist in the world were completely discredited, I would just shrug and do effective altruism on my own. If they instituted the death penalty for effective altruism, I would do it under cover of night using ZCash. And I’m nowhere near the most committed effective altruist; honestly I’m probably below average. “Saint gets eaten by lions in Colosseum, can early Christianity possibly survive this setback?” Update your model or prepare to be constantly surprised. 6 traders. So, we lost several hundred million dollars of funding in a giant disaster which was also morally outrageous and demoralizing. It happens. But lots of people have already emailed me asking how to send in more money to help fill the gap. Some added something like “it was so depressing that all the FTX money meant my money didn’t make a difference, but now I can help again, and it’s great!” Can these people fill the hole? 32% chance that they can! 10 traders. And if they don’t, we’ll still probably do better than in 2021, before all the FTX money started rolling in. We’ll try harder to hammer in the point about not doing “ends justify the means” reasoning, and do some reorgs and purges to prevent anything like this from happening again, we’ll make a bunch of other changes - some reasonable, some panic-driven - but we’ll go on. If all the far-future stuff collapses, we’ll donate to global health charities. If the global health charities don’t work, we’ll fund GiveWell to sit around and figure out something that does. If GiveWell gets hit by an asteroid, we’ll work on asteroid deflection (actually I think we might already be doing that). If asteroid deflection turns out to be -EV, we’ll switch to shrimp welfare, or give ourselves Zika virus, or any of a million other things. You have no idea how committed we are to continuing to do effective altruism regardless of whether or not it’s “popular”. But it will be popular. 45 traders, resolution criteria at the link, notice the dip when the FTX news broke, followed by recovery as people had time to think it over more. Moving on to slightly less serious topics: The snapshot doesn’t show this, but one of the suggestions is Atlas Rugged. 67 traders, interesting to see where forecasters’ priorities lie. This was a big rumor early on, along with “everyone was on meth”, but the on site psychiatrist said it was false during an interview. 13 traders. WHY DO PEOPLE KEEP GOING ON PODCASTS? Midterms! That was two weeks ago? It feels like years! A week before the midterms, I wrote: Polymarket, Manifold, and PredictIt now have shiny interfaces for predicting the upcoming US midterm elections. In terms of the Republicans taking the Senate, Polymarket is at 65%, Manifold at 58%, PredictIt at 73%, and 538 at 49%. Congratulations 538! Mike Saint Antoine (who wrote the review of Viral in the last Book Review Contest) has put some more work into scoring midterm election forecasts. Here are some headline results: Mike writes: The reason I didn’t just do a three-way comparison between PredictIt, FiveThirtyEight, and Manifold Markets is that the Manifold Markets forecasts included fewer questions than the PredictIt and FiveThirtyEight forecasts. So in order to do a fair comparison here, I’ll be comparing the smaller subset of questions for which PredictIt and Manifold Markets both gave a forecast. So it looks like both Manifold and 538 did better than PredictIt, and there’s no clear way to tell which of the former did better. (except I guess you could do this analysis with just the subset of questions Manifold and 538 share, but Mike didn’t and I’m also not going to). PredictIt has a pretty consistent Republican bias (it’s a minor epistemic sin to accuse a prediction market of having a predictable bias unless you’ve made money exploiting it, I made $600 this election so I’ll let myself pass). In years when Republicans do better than expected, it will probably look better than other markets; in years when they do worse, it will look worse. Still, this is a bias, so I think we should take them doing worse this year as a fair reflection of their accuracy, even thought next year it could go the other way. My main two takeaways here are: PredictIt isn’t yet good enough that the ideal theorems showing prediction markets should be unbiased and better than everyone else apply to it. The obvious explanation is its $800-per-question cap. Polymarket doesn’t have that cap and it did better, although Mike hasn’t done a formal comparison to 538.
Mike writes: The reason I didn’t just do a three-way comparison between PredictIt, FiveThirtyEight, and Manifold Markets is that the Manifold Markets forecasts included fewer questions than the PredictIt and FiveThirtyEight forecasts. So in order to do a fair comparison here, I’ll be comparing the smaller subset of questions for which PredictIt and Manifold Markets both gave a forecast. So it looks like both Manifold and 538 did better than PredictIt, and there’s no clear way to tell which of the former did better. (except I guess you could do this analysis with just the subset of questions Manifold and 538 share, but Mike didn’t and I’m also not going to). PredictIt has a pretty consistent Republican bias (it’s a minor epistemic sin to accuse a prediction market of having a predictable bias unless you’ve made money exploiting it, I made $600 this election so I’ll let myself pass). In years when Republicans do better than expected, it will probably look better than other markets; in years when they do worse, it will look worse. Still, this is a bias, so I think we should take them doing worse this year as a fair reflection of their accuracy, even thought next year it could go the other way. My main two takeaways here are: PredictIt isn’t yet good enough that the ideal theorems showing prediction markets should be unbiased and better than everyone else apply to it. The obvious explanation is its $800-per-question cap. Polymarket doesn’t have that cap and it did better, although Mike hasn’t done a formal comparison to 538.
November 07, 2024 · Original source
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6 Committee

1/6 Committee is a recurring organization in the Astral Codex Ten archive, appearing 1 times across 1 issues between July 12, 2022 and July 12, 2022. The archive places it in contexts such as "the revelations from the 1/6 Committee are so damaging". It most often appears alongside Africa, Berkshire Hathaway, Boris Johnson.

Reference entry
6 Committee
Mention count
1
Issue count
1
First seen
July 12, 2022
Last seen
July 12, 2022
  • 22 July 12, 2022
July 12, 2022 · Original source
I thought of this last week while reading Is Conservative Media Breaking Up With Trump? The Daily Beast argues that the revelations from the 1/6 Committee are so damaging that even previously-loyal GOP elites are starting to turn on their former master. And with DeSantis as such a tempting alternative 2024 nominee, maybe Trump is more of a liability than an asset. Is this finally the jam ol Donny Trump can’t wriggle his way out of?
101st Airborne

101st Airborne is a recurring organization in the Astral Codex Ten archive, appearing 1 times across 1 issues between August 09, 2024 and August 09, 2024. The archive places it in contexts such as "the stout resistance of the 101 st Airborne at Bastogne". It most often appears alongside Admiral Ernest King, Albert Speer, Allied.

Reference entry
101st Airborne
Mention count
1
Issue count
1
First seen
August 09, 2024
Last seen
August 09, 2024
August 09, 2024 · Original source
...mans to drive back the western Allies’ advance, was almost pathetic in its hopelessness. We Americans tend to focus on the hard fighting at the outset of the battle, and the stout resistance of the 101 st Airborne at Bastogne. Knowing that airpower would make their attack impossible, the Germans timed the battle for bad weather and prayed it lasted as long as possible. Prayer was really the o...
1517

1517 is a recurring organization in the Astral Codex Ten archive, appearing 1 times across 1 issues between March 23, 2023 and March 23, 2023. The archive places it in contexts such as "started a new VC fund, 1517 (named after the year Martin Luther did some institution-challenging of his own)"; "1517 made $200 million from the deal". It most often appears alongside a priori truths, Abraham Lincoln, Albert van Dam.

Reference entry
1517
Mention count
1
Issue count
1
First seen
March 23, 2023
Last seen
March 23, 2023
March 23, 2023 · Original source
An advertisement for the author’s hedge fund Michael Gibson’s memoir Paper Belt On Fire succeeds on all counts. The year was 2007. Gibson had just dropped out of Oxford (grad student, philosophy), and applied for a job with the CIA. His secret reason: when he was one year old, his father had admitted to his mother that he was a spy and might be in danger. Before he could tell her anything else, he was found dead, apparently of a heart attack. He thought maybe if he worked at the CIA, he would have access to more information about what happened. The CIA evaluated him (along with a telephone interview, an “IQ test, a personality test, a statement of values, [and] a set of essay questions”) and rejected him. Gibson got a job as an editorial assistant at a tech magazine and blogged on the side. Some of his blog posts came to the attention of Peter Thiel, who offered him a job at his hedge fund. Wasn’t it a bit bold to offer an Oxford philosopher a hedge fund job? Yes, the book mentions how brave and radical and unconventional Thiel’s hiring policies are about twice per paragraph. For example: The media consistently gets Peter wrong . . .The Atlantic’s George Packer wrote . . . that Peter’s hedge fund had the reputation of being a “Thiel cult” that was “staffed by young libertarian brains who were in awe of their boss, emulating his work habits, chess-playing, and aversion to sports.” Packer is a great writer, but in this he was dead wrong, as anyone actually working on the desk knew. Sure, Patrick “the Wolf Man” Wolff was technically a chess grandmaster, ranked higher than Peter, but hardly anyone else ever played. More importantly, the Wolf Man was a diehard Krugman Keynesian. Woersching was a lefty, too, an ardent fan of the egalitarian philosophy of John Rawls. And Josh, he was a dirt-road California Democrat who was a downhill ski junkie […] In truth, Peter didn’t hire just libertarians. He hired scapegoats who’d survived a mob. People who felt comfortable being a minority of one. Thiel in no way selects employees who agree with all of his controversial libertarian opinions. But, by total coincidence, Michael Gibson does agree with all of Peter Thiel’s controversial libertarian opinions. He writes about Cardwell’s Law; historian Donald Cardwell noted that no country remains on the cutting edge for long. During the early Renaissance, Italy was where it was at; a century later, it was Spain and Holland; later still, Britain and Germany, and now new discoveries and businesses come disproportionately from the United States. Why? Gibson and Thiel think that innovation is a rare and fragile plant, which thrives only in the hidden cracks between power structures. Established structures either stamp it out as a threat, or rent-seek off of it so hard that they bleed it dry. Wherever it succeeds, it has succeeded through weird quirks that prevent fat cats from parasitizing it to death. Hong Kong’s economic miracle was during the administration of John Cowperthwaite, an eccentric British libertarian who refused to collect economic statistics because he thought they would make it too easy for meddlers to extract value. America’s economic miracle happened because of a vast frontier - which not only provided freedom for westerners, but served as a BATNA for easterners, preventing their own institutions from sucking them too dry. Now the frontier has closed. New York City recently abandoned its attempt to build a light rail line to the airport: after reaching a $2.4 billion price tag and spending eight years in the planning phase, the government realized it wouldn't be able to overcome all the legal hurdles necessary to grant itself permission. The San Francisco Chronicle reported that it requires 87 permits, two to three years, and $500,000 to get permission to build houses in SF - and your plan might still get shot down because a planning commissioner thinks its glass windows are “a statement of class privilege”. The cracks have shut; the rare fragile plant has been shredded by a combine harvester. Gibson, like Thiel, is a believer in the Great Stagnation - the theory that we’re already reaping the consequences of our newly parasitic society. The early 20th century gave us cars, airplanes, electricity, and penicillin; the early 21st has so far given us some truly excellent social media sites but not much else. Innovation in the world of bits - unbound by geography, comparatively hard to regulate or extort - has sort of continued; innovation in the world of atoms has ground to a halt. And Gibson, like Thiel, talks like a man on a mission. What is good in man thrives only in a few tiny cracks, easily found and destroyed. The last crack was closed within living memory, but its legend hasn’t completely died; the few people who managed to pick up a little of its lore are racing against time to open a new crack before it is entirely forgotten and their project is left to the vicissitudes of history. The cover of “Paper Belt On Fire” goes hard. And yes, the “money” part is a reference to Bitcoin. Gibson’s heart was originally in charter cities - asking some government to open a tiny controlled crack in a sliver of its territory, promising it more meat in the end if it lets its victims grow fat and healthy than if it strangled them in the cradle. But for whatever reason they thought the time wasn’t ripe (the right time, apparently, would be 2019). Instead, Thiel asked Gibson to work on what would become the Thiel Fellowship. He teamed up with Danielle Strachman, a dangerously-hippie-adjacent burnt-out former charter school principal. Their plan was simple: offer talented kids $100,000 to drop out of school and do something exciting in the real world (usually start a company). Paper Belt spends long pages on the hate they got. Larry Summers called it “the single most misdirected bit of philanthropy this decade”. Journalist Jacob Weisberg said anyone who accepted the Fellowship would “halt their intellectual development at the onset of adulthood, maintaining a narrow-minded focus on getting rich as young as possible and thereby avoid the siren lure of helping others or pursuing knowledge for its own sake” (this was before journalists decided that helping others was also evil). Others focused on how there was no way any of these young people would possibly succeed or make money - when the first batch of Thiel fellows failed to revolutionize the world within one year, journalist Vivek Wadhwa wrote Billionaire’s Failed Education Experiment Proves There’s No Shortcut To Success. In fact (slightly conflating the part with the Fellowship with its successor fund): The press . . . hated us. In a 2016 New York Times op-ed, science journalist and author Tom Clynes claimed that “radical innovation has yet to emerge” from anything related to the Thiel Fellowship, and that “the biggest hits have been the most pedestrian.” Antonio Garcia Martinez, the author of the Silicon Valley memoir Chaos Monkeys, spewed forth his bile for us on social media: “For fans of ironic stupidity, Silicon Valley is a never-ending feast”, he wrote on Facebook. He went on to explain, with great vulgarity, why our fund would fail by backing young dropouts. My favorite . . . has to be the challenge issued by Scott Galloway, a professor and bloviator in marketing from NYU’s business school . . . who told Business Insider that if he picked ten smart recent graduates from his alma mater, the University of California at Berkeley, they would outperform any ten dropouts we worked with on some dimension of success related to income or startup formation. Of course he wouldn’t have written the book if any of these people had been right. I can’t find a list of all Thiel fellows, but there are ~20 per year and it’s been running about 12 years, so maybe 200 - 250? At least eight have founded companies valued at over a billion dollars, and others have become impressive philanthropists, activists, and scientists. Pretty good success rate. Gibson argues it’s not about the money, it’s about the mission. We’ve told young people they can’t succeed without the stamp of approval from big institutions. In order to get that stamp, they sacrifice their childhood on the altar of doing things that look nice to admissions officials, then go deep into debt to pay ruinous tuitions. All to waste four years of their lives listening to some professor drone on about post-colonial gender relations in Harry Potter so they can satisfy their gen ed requirement so they can learn the stuff they want to learn so they can get hired by McKinsey so that one day they can be cool and important enough to make a difference in the world. Why not tell young people they can just make the difference right now, without doing any of that? It’s not about the money - but when your graduates are routinely founding billion dollar companies, you’d be crazy to keep it that way. After a few years, Gibson and Strachman noticed the billion-dollar-bill lying on the ground, left the Thiel Fellowship, and started a new VC fund, 1517 (named after the year Martin Luther did some institution-challenging of his own). Their business plan was to do roughly the same thing as the Thiel Fellowship - only this time, invest in the companies beforehand (the parting with Thiel seems to have been amicable; he invested $4 million). So Gibson adopted the life of a venture capitalist. He talks frankly about the difficulties. For example, in one case he found someone nobody else believed in, gave them enough money to keep going, and helped them start their company in exchange for them giving Gibson a certain stake. After the company succeeded, Gibson accuses bigger VC firm Sequoia Capital of convincing the founder to kick him out, and stealing his stake. He says that in the world of VCs it’s poison to sue founders for any reason, so nobody can enforce contracts, so if your founders defect to a different VC for more money, there’s nothing you can do (this is not legal advice). Also, “please give me millions of dollars so I can invest it in college dropouts” is a tough sale for everyone except Peter Thiel. Still, he got a bit of money and tried his best. He takes as his - would it be insensitive to say “role model”? - John Walker Lindh, the American who defected to the Taliban (and who he apparently looked like). Probably it depends on the angle or something. Lindh was the only American to find Osama bin Laden in the early 2000s - he went to lots of jihadi training camps in the process of learning how to jihad, and Osama happened to be at one of them. The lesson, Walker says, is that if you want to find people who are hard to find, you need to steep yourself in their culture, truly understand them, become one with them. Good founders are hard to find. But he and Strachman went to dozens of dingy college dorms, math competitions, group houses, and hackathons, looking for people with the right sort of talent. After pooh-poohing IQ (“Marilyn vos Savant is listed as having the highest recorded IQ, and what does she do? She writes a column for a Sunday supplement in the newspaper”) he lists some of his own preferred metrics for judging would-be Thiel fellows and founders: Polytropon - a famously untranslatable Greek word (“of-many-turns”? “always-has-a-trick-up-his-sleeve” “clever bastard”?) used to describe Odysseus. Edge control - willingness to constantly surf the boundary between order and disorder Crawl-walk-run - ability to scale from a tiny startup to a big company. …and several others, including “tensive brilliance” and “Friday night Dyson sphere”. He and Danielle searched the country for people with these qualities, annoying colleges (he was banned from MIT after showing up too often to convince their students to drop out) and doing various stunts (on October 31 2017, the 500th anniversary of Luther’s theses, he nailed a list of anti-formal-education theses to the doors of the admin buildings of top colleges (“Our commercial printer had misunderstood our request and printed them on seven-foot-long scrolls. They were ridiculous . . . but it turned out for the best.”) At one point, he negotiated with a brilliant 21 year old who may have discovered a transformative diabetes therapeutic, but the hidebound conformist novelty-hating establishment refused to work with him just because he liked the Marvel Cinemat - okay, fine, he may have legally changed his name to “Tony Stark”. Still, Gibson saw past his eccentricities, helped him start his company, and gave him sage advice (he should introduce himself to other investors as “Anthony”). Skip through several more chapters of everyone hating Gibson and telling him he was wrong and refusing to give him money and cheating him out of the money he already had, and the payoff is Luminar. One of the dropouts they cultivated founded a beyond-cutting-edge lasers-for-self-driving-cars company which went public at $3 billion. 1517 made $200 million from the deal - it sounds like they had only ever raised about $25 million, so their investors must have octupled their money on that company alone. Everyone involved is now very rich, and Gibson considers his anti-education thesis on the way to being proven. The book ends with a newly-resourced Gibson continuing his quest to figure out whether and why the CIA killed his father, but it’s slow going. If any of you know a guy named Albert van Dam in Amsterdam, or how to convince Swiss banks to reveal secret account information, get in touch with him. II. A common pattern: I assert something. Everyone yells at me and tells me I’m wrong and stupid, sometimes in very colorful language. I wait, time proves me right, and I write an essay gloating educating people about this. The median comment is “of course this is true, nobody ever denied this was true, why are you wasting our time with something obvious?” I hate this and I try to avoid doing it to other people. This is too bad, because I’m tempted to say: obviously talented dropouts can start good companies. We’ve known this at least since Bill Gates dropped out of Harvard in 1975 to start Microsoft. But also, obviously they can. Brilliant and driven people can succeed whether they get a college education or not. If Bill Gates had stayed an extra two years at Harvard, he probably would have taken a few more advanced math classes not really related to programming software or running a company. So why should we even have as a hypothesis that he couldn’t start Microsoft successfully without doing that? Still, Gibson adequately proves that lots of people hated him and were sure he would fail. Either we should read this backwards - learn that there was once a time when pro-college messages were even stronger than now, so strong that people thought it was literally impossible to succeed without every single day of a four-year college application - or the critics were trying to get at something deeper they were bad at expressing. For example: what, exactly, is Gibson’s alternative to the education system? The back-of-book-blurb says Paper Belt On Fire is about “how higher education and other institutions must evolve to meet the dire challenges of tomorrow” - but evolve how? What exactly has been proven here? A few of the very brightest young people, hand-picked by an expert young-person-picker and given $100K, can become billionaires or make great discoveries without a college degree. What are the implications? Suppose you are an average college student with an average level of talent and motivation. Should you drop out and try to create a company for Peter Thiel? Based on how many average-talent people Thiel rejects, even he doesn’t think you should do that. And if you don’t have a good answer to this question - the one relevant to 99.9% of education system inmates - have you really launched a challenge to the educational system? Gibson doesn’t address this question, but I predict he would admit that, fine, he doesn’t have an alternative to the education system in the sense of “educate people this way rather than that way”. He just wants less formal education, and has proven this will work fine. True, he’s only proven it for a tiny subset of ultra-talented people. But “billionaire tech founder” is a hard job - if it wasn’t, more people would do it and reap the $1 billion reward. Proving that people can become billionaire tech founders without college degrees implicitly suggests they can be successful middle managers or budget analysts without college degrees. So the sort of companies that need middle managers and budget analysts should also consider hiring people without degrees, and the sorts of average-level-of-talent-and-motivation people who want these jobs should consider skipping college. Would this work? Probably. It worked in the early 1900s, when only 5-10% of Americans had college degrees but the country seemed about as dynamic and successful as it does now. It worked for people like George Washington, Abraham Lincoln, and Thomas Edison, none of whom went to college. It works in other countries - for example in the UK where young doctors skip undergrad and go straight to medical school, and whose patients get about the same outcomes as in the US. It works for people with impractical degrees like philosophy, who are constantly getting jobs in (and doing well in) fields that don’t require you to compare Locke vs. Leibniz’s perspective on a priori truths. So this would work if everyone agreed to do it at once, which they won’t. The way college gets you is adverse selection. Suppose that tomorrow, you - a smart and hard-working person who could easily get a college degree - decline to do so, because you appreciate Peter Thiel and Michael Gibson’s anti-institutional perspective. The pool of people without college degrees is now, to a first approximation: 200 million people who weren’t smart to get in, rich enough to afford it, or motivated enough to finish.
Probably it depends on the angle or something. Lindh was the only American to find Osama bin Laden in the early 2000s - he went to lots of jihadi training camps in the process of learning how to jihad, and Osama happened to be at one of them. The lesson, Walker says, is that if you want to find people who are hard to find, you need to steep yourself in their culture, truly understand them, become one with them. Good founders are hard to find. But he and Strachman went to dozens of dingy college dorms, math competitions, group houses, and hackathons, looking for people with the right sort of talent. After pooh-poohing IQ (“Marilyn vos Savant is listed as having the highest recorded IQ, and what does she do? She writes a column for a Sunday supplement in the newspaper”) he lists some of his own preferred metrics for judging would-be Thiel fellows and founders: Polytropon - a famously untranslatable Greek word (“of-many-turns”? “always-has-a-trick-up-his-sleeve” “clever bastard”?) used to describe Odysseus. Edge control - willingness to constantly surf the boundary between order and disorder Crawl-walk-run - ability to scale from a tiny startup to a big company. …and several others, including “tensive brilliance” and “Friday night Dyson sphere”. He and Danielle searched the country for people with these qualities, annoying colleges (he was banned from MIT after showing up too often to convince their students to drop out) and doing various stunts (on October 31 2017, the 500th anniversary of Luther’s theses, he nailed a list of anti-formal-education theses to the doors of the admin buildings of top colleges (“Our commercial printer had misunderstood our request and printed them on seven-foot-long scrolls. They were ridiculous . . . but it turned out for the best.”) At one point, he negotiated with a brilliant 21 year old who may have discovered a transformative diabetes therapeutic, but the hidebound conformist novelty-hating establishment refused to work with him just because he liked the Marvel Cinemat - okay, fine, he may have legally changed his name to “Tony Stark”. Still, Gibson saw past his eccentricities, helped him start his company, and gave him sage advice (he should introduce himself to other investors as “Anthony”). Skip through several more chapters of everyone hating Gibson and telling him he was wrong and refusing to give him money and cheating him out of the money he already had, and the payoff is Luminar. One of the dropouts they cultivated founded a beyond-cutting-edge lasers-for-self-driving-cars company which went public at $3 billion. 1517 made $200 million from the deal - it sounds like they had only ever raised about $25 million, so their investors must have octupled their money on that company alone. Everyone involved is now very rich, and Gibson considers his anti-education thesis on the way to being proven. The book ends with a newly-resourced Gibson continuing his quest to figure out whether and why the CIA killed his father, but it’s slow going. If any of you know a guy named Albert van Dam in Amsterdam, or how to convince Swiss banks to reveal secret account information, get in touch with him. II. A common pattern: I assert something. Everyone yells at me and tells me I’m wrong and stupid, sometimes in very colorful language. I wait, time proves me right, and I write an essay gloating educating people about this. The median comment is “of course this is true, nobody ever denied this was true, why are you wasting our time with something obvious?” I hate this and I try to avoid doing it to other people. This is too bad, because I’m tempted to say: obviously talented dropouts can start good companies. We’ve known this at least since Bill Gates dropped out of Harvard in 1975 to start Microsoft. But also, obviously they can. Brilliant and driven people can succeed whether they get a college education or not. If Bill Gates had stayed an extra two years at Harvard, he probably would have taken a few more advanced math classes not really related to programming software or running a company. So why should we even have as a hypothesis that he couldn’t start Microsoft successfully without doing that? Still, Gibson adequately proves that lots of people hated him and were sure he would fail. Either we should read this backwards - learn that there was once a time when pro-college messages were even stronger than now, so strong that people thought it was literally impossible to succeed without every single day of a four-year college application - or the critics were trying to get at something deeper they were bad at expressing. For example: what, exactly, is Gibson’s alternative to the education system? The back-of-book-blurb says Paper Belt On Fire is about “how higher education and other institutions must evolve to meet the dire challenges of tomorrow” - but evolve how? What exactly has been proven here? A few of the very brightest young people, hand-picked by an expert young-person-picker and given $100K, can become billionaires or make great discoveries without a college degree. What are the implications? Suppose you are an average college student with an average level of talent and motivation. Should you drop out and try to create a company for Peter Thiel? Based on how many average-talent people Thiel rejects, even he doesn’t think you should do that. And if you don’t have a good answer to this question - the one relevant to 99.9% of education system inmates - have you really launched a challenge to the educational system? Gibson doesn’t address this question, but I predict he would admit that, fine, he doesn’t have an alternative to the education system in the sense of “educate people this way rather than that way”. He just wants less formal education, and has proven this will work fine. True, he’s only proven it for a tiny subset of ultra-talented people. But “billionaire tech founder” is a hard job - if it wasn’t, more people would do it and reap the $1 billion reward. Proving that people can become billionaire tech founders without college degrees implicitly suggests they can be successful middle managers or budget analysts without college degrees. So the sort of companies that need middle managers and budget analysts should also consider hiring people without degrees, and the sorts of average-level-of-talent-and-motivation people who want these jobs should consider skipping college. Would this work? Probably. It worked in the early 1900s, when only 5-10% of Americans had college degrees but the country seemed about as dynamic and successful as it does now. It worked for people like George Washington, Abraham Lincoln, and Thomas Edison, none of whom went to college. It works in other countries - for example in the UK where young doctors skip undergrad and go straight to medical school, and whose patients get about the same outcomes as in the US. It works for people with impractical degrees like philosophy, who are constantly getting jobs in (and doing well in) fields that don’t require you to compare Locke vs. Leibniz’s perspective on a priori truths. So this would work if everyone agreed to do it at once, which they won’t. The way college gets you is adverse selection. Suppose that tomorrow, you - a smart and hard-working person who could easily get a college degree - decline to do so, because you appreciate Peter Thiel and Michael Gibson’s anti-institutional perspective. The pool of people without college degrees is now, to a first approximation: 200 million people who weren’t smart to get in, rich enough to afford it, or motivated enough to finish.
16th Central Committee

16th Central Committee is a recurring organization in the Astral Codex Ten archive, appearing 1 times across 1 issues between April 13, 2022 and April 13, 2022. The archive places it in contexts such as "elected a full member of the 16th Central Committee". It most often appears alongside Alaska, Aristotle, Artbreeder AI.

Reference entry
16th Central Committee
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1
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1
First seen
April 13, 2022
Last seen
April 13, 2022
April 13, 2022 · Original source
In Fujian, Xi made efforts to attract investment from Taiwan and to strengthen the private sector of the provincial economy. In February 2000, he and then-provincial Party Secretary Chen Mingyi were called before the top members of Central Politburo Standing Committee of the CCP – General Secretary Jiang Zemin, Premier Zhu Rongji, Vice-President Hu Jintao and Discipline Inspection Secretary Wei Jianxing – to explain aspects of the Yuanhua scandal. In 2002, Xi left Fujian and took up leading political positions in neighbouring Zhejiang. He eventually took over as provincial Party Committee Secretary after several months as acting governor, occupying a top provincial office for the first time in his career. In 2002, he was elected a full member of the 16th Central Committee, marking his ascension to the national stage.
1938 FDA

1938 FDA is a recurring organization in the Astral Codex Ten archive, appearing 1 times across 1 issues between March 02, 2021 and March 02, 2021. The archive places it in contexts such as "Did you know that the 1938 FDA refused to even do a cost-benefit analysis on DNP". It most often appears alongside 2,4-dinitrophenol, 2,4-dinitrophenol, ADP/ATP carrier.

Reference entry
1938 FDA
Mention count
1
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1
First seen
March 02, 2021
Last seen
March 02, 2021
March 02, 2021 · Original source
The rashes, liver problems, and peripheral neuropathy would be my main worries, but they haven’t been studied very well and I don’t know if they’re more like 1/10 or 1/10,000. Did you know that the 1938 FDA refused to even do a cost-benefit analysis on DNP because they thought it had no benefits? This was before people really understood the dangers of obesity; they thought it was just a cosmetic problem.
2 Hour Learning, Inc

2 Hour Learning, Inc is a recurring organization in the Astral Codex Ten archive, appearing 1 times across 1 issues between June 27, 2025 and June 27, 2025. The archive places it in contexts such as "the charter school application of “ Unbound Academy ”, a subsidiary of “ 2 Hour Learning, Inc ”". It most often appears alongside 10,000 hour rule, 2-hour Learning, Alex Amplifier.

Reference entry
2 Hour Learning, Inc
Mention count
1
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1
First seen
June 27, 2025
Last seen
June 27, 2025
June 27, 2025 · Original source
In January 2025, the charter school application of “Unbound Academy”, a subsidiary of “2 Hour Learning, Inc”, lit up the education press: two hours of “AI‑powered” academics, 2.6x learning velocity, and zero teachers. Sympathetic reporters repeated the slogans; union leaders reached for pitchforks; Reddit muttered “another rich‑kid scam.” More sophisticated critics dismissed the pitch as “selective data from expensive private schools”.
2-Hour Learning’s flagship school is the “Alpha School” in Austin Texas. The Alpha homepage makes three claims:
Same state curriculum, same worksheets, same pace. The school philosophy was “no acceleration—just go deep.” We knew this was the philosophy going in. The pitch was that instead of accelerating through the state curriculum the teachers would take their time with the kids and allow them to fully explore and master the content of each grade. When we asked for examples of what that meant in practice we were told things like: “Instead of reading more advanced vocabulary, the students will learn to read out loud and use emotion and character impressions. They will learn how to vary the timing of their reading like where and when to pause to create emotion in the listener”. That sounded reasonable! It sounded like more learning, but just different learning than what the state had mandated. In practice that was not what happened. In practice “deep” just meant “un‑measured.” Smart kids + small classes ≠ accountability. The kids had time to do music, lego building, theatre and Friday ski trips because they were all really bright. They didn’t need 6+ hours a day to learn the limited math required by the state, and since the school did not feel the need to advance faster than the state, there was no pressure to push learning at all – on anything really. There was no overall school curriculum. Every teacher did their own thing. While one first grade class had weekly spelling bees, the teacher in the other classroom did not believe in learning spelling at all. But it didn’t matter. The metrics they measured the kids on in both classes advanced “enough” that no one was concerned. Most time wasn’t spent on math or language anyway. Beyond the brochure activities like skiing and theater and the four hours of foreign language per week they split between Spanish and Mandarin (which was really a great opportunity for the kids who already spoke Spanish and Mandarin to have their egos flattered. I did not see any learning in either language class. I don’t see how you can teach a language a couple of hours a week to a group of 18 kids with skill levels from zero to fluency and expect to have any impact), a lot of time was spent on DEI. DEI was pitched as helping kids handle the emotions that often come from being sensitive gifted children (they called it “Synapse”). In practice my oldest daughter got four years of learning about the basic ideas of Martin Luther King Junior and Rosa Parks, a rough understanding that some people are non-binary, and a great deal of anxiety every time I left the water running while I was brushing my teeth. The talent drain In Spring 2024 the “intermediate-school” head resigned, as did the 40+ year veteran science teacher we had been looking forward to our daughter having, the beloved tech teacher who had built a her own proprietary “learn to type” software, plus half the lower‑school faculty. Our oldest was going to be entering fourth grade; her incoming roster read like a rebuilding year for a professional sports team. It was possible we could get her into a middle school that would feed into a top tier high school, but those did not start until 5th grade. Our best option looked like “suck it up and accept whatever we had for at least a year”. One option was to do something radical. We considered taking a GAP year and traveling the world with an organization called “Boundless” but decided the timing wasn’t right. Earlier in the year we had started exploring moving to the charter city of Prospera. There is a Montessori school there that seemed like it might be alright. And we could surround the kids with an interesting group of people (and live on the beach!). But by the spring we had ruled it out. There did not seem to be many families as part of the community and we were not comfortable with the risk profile based on what was happening with the conflict between Honduras and their charter cities. Then I stumbled across Alpha: Two‑hour mornings, life‑skills afternoons, claims of 2x learning. Marketing copy is cheap; still, the promise was different enough to warrant due diligence. The initial plan was to fly some of the kids to Austin for an Alpha summer camp for a week in June – just to try it out. But once we started exploring more my wife asked me: “Could we actually move to Austin and try it for a year? Based on what is happening at the kids' school, this might be the year to try it.” So over eight weeks we flew to Austin five times – conversations with admissions and school heads, real estate searches, kids doing shadow‑days. Every parent we spoke to was very impressed with the school. Their kids really were advancing at 2x+ speed – and no one believed it was just a “selection effect”. And every guide I spoke to was extremely impressive themselves. They reminded me of the staff you run into when visiting Disney World. They all seemed “full faced” and fully-engaged. When I asked the head of admissions how they found such good staff he told me their compensation was fully transparent. “Associate Guides” were paid $60,000/year (vs the $40,000 average for Austin teachers), “Full Guides” made $100,000 and the five “Head Guides” in the school each made $150,000. They were able to both poach the best teachers from other schools, but also bring exceptional people into teaching that would not have considered it otherwise. It also let them have very high expectations for teachers once they were hired. We pulled the trigger in July. New house. Admissions letter signed. Moving truck (plus car-mover) scheduled for October. Worst case, it would be a one‑year sabbatical from stagnation. The hypothesis I carried south Elite private school attendance buys you smaller classes, brighter kids, and fancier field trips – not academic acceleration. If Alpha was real, we’d see that differential, measurable impact by Christmas – that was when we would need to decide if we would cut bait and re-apply to schools back home (and sign the kids up for more IQ-tests. The school would not accept old ones). That prior—show me velocity, not polish—is the lens through which the rest of this review should be read. Part Two: A History of Alpha Note: This is my best attempt at piecing together the history of the school based on conversations with co‑founder MacKenzie Price, high school head Chris Locke, Alpha staff, and Alpha parents; All dates are estimates and I am SURE I have gotten some details wrong. I will come back after the fact in the comments and make corrections as I hear from the people involved with corrections. 2013 – 2017 | Garage‑School to “Alpha” MacKenzie Price, then a mortgage broker in Austin, wasn’t impressed by the city’s gifted programs. She invited a small number of neighbourhood kids (including her two) into a makeshift microschool that ran two intense, teacher‑led academic “sprints” each morning, then “life‑skills” projects after lunch. Joe Liemandt — Founder of Trinity Technology, ESW Capital billionaire and family friend (MacKenzie’s husband worked for him) — kept his own children in conventional private school until he saw the qualitative improvement in the life skills of MacKenzie’s kids. He decided he wanted his kids to join MacKenzie’s but he wanted to take the project to the next level. Sometime around 2014-2017 he joined MacKenzie as a co-founder and started writing checks. Alpha recruited more students and guides and the operation jumped from location-to-location looking for a larger permanent home. 2017 – 2020 | K-8 Expansion and 2-hour focus Alpha grew to roughly 90 students from K‑8 and stabilized. Morning “core blocks” were still teacher‑driven (20‑minute bursts, 5‑minute breaks, rinse, repeat), but focused on students engaged in exercises with rapid feedback (not lectures). Afternoon workshops covered “life skills” like how to give and receive feedback or public speaking. I have not seen academic data from this time period, but when I spoke to Chris Locke, head of Alpha’s high school (which launched around 2020), he told me the kids coming into his 9th grade program were “fine,” academically – it was their life skills, confidence, and ability to engage with adults and their peers were exceptional. At this stage no AI, no dashboard, no 2x learning, no portal — just better ratios and focused pacing and the result was well balanced kids who were enjoying their education experience (even if they were unexceptional academically). 2020 – 2022 | Platform Era Begins Somewhere along the way Liemandt hired a small engineering team to stitch together edtech learning tools. Many schools use tools like iXL, Beast Academy and Amira. Those tools fit in well with the 2-hour structured approach Alpha was using. The “platform” Liemandt’s team built was meant as a tool to free up guide time so that students could be more self-directed. The dev team stitched together the preferred off‑the‑shelf apps behind a single login, and built out tracking and dashboards so guides (and students) could easily see how they were progressing. This also gave the curriculum team (there was a curriculum team now) data to understand where students were spending their time, what tools were working, and which weren’t as effective. The Alpha Portal was born. Not only did it increase efficiency, it provided data to iterate with. Chris Locke saw the curve change incrementally: each new cohort of ninth‑graders under the new tech-enabled learning platform came in a little stronger academically. The “life skills” were now being matched by the “academic skills”. 2022 | Expansion and Iteration By having access to Alpha kids post-graduation in the high school, Locke could send feedback back to the elementary school.The kids coming out of the new program were now killing it academically on Math, Language, and Science, but they were still weak on things like History and Geography. He fed that type of information back to the curriculum designers, who iterated and improved the program. Soon, in addition to the core platform that directed students to third-party tools, the tech team was building proprietary “Alpha” tools themselves. The flagship of the in-house tools was “AlphaReads”. AlphaReads requires students to read progressively more complicated passages, followed by answering reading comprehension questions. In addition to helping the kids improve reading skills, Alpha uses it to push types of content. Instead of classes in history, geography, economics and political science, some of the reading passages will cover that material (in addition to learning how to read and understand Shakespeare and Proust). The success of the 2-hour learning platform was giving the Alpha founders confidence. Liemandt in particular wanted to see if the program had legs beyond the elite group of students being educated in Austin. Alpha’s first external test in August 2022 in Brownsville, TX – a small community on the Mexico border with less than half the per capita income of Austin. SpaceX had recently launched Starbase in Brownsville in 2014 and the employees there were not happy with the existing school options. Someone at SpaceX approached Alpha and asked if they could launch a new campus for their employees. It is unclear if any money changed hands, but when Alpha launched their Brownsville campus (available to SpaceX employees and any other locals who are interested) tuition was only $10,000 (vs $40,000 at the main Austin campus); incoming students trailed national academic standards by over a year. But after nine months on the Alpha program the first cohort of students had caught up and surpassed the national average, and they kept accelerating, achieving an average learning velocity of ~2× the national average (see section four for what that means). Brownsville was Alpha’s attempt to show that their model wasn’t just rich‑kid selection effects. Spring 2024 | Field Pilots & Ukraine Trip Alpha tuition is high for the Austin area ($40,000 vs average private school ~$10,000-$15,000), but unlike most private schools tuition is all-inclusive. There are no extra fees for computers or field trips. There are no silent auctions or appeals for donations. This “no extra fees” allows the school to do some pretty ridiculous things. In the first half of 2024 Alpha sent a group of students to Poland to help launch a 2-hour learning pilot among Ukrainian refugees. Students did not pay to go on the trip. But students also did not have a “right” to go on the trip. They had to earn it. In addition to being on top of academic and non-academic expectations, students who wanted to participate had to learn basic Ukrainian so they could interact with the students in Poland they were meant to be helping. By not linking the opportunity to payment, the school could instead link it to behavior and achievement. This year a group of kids who learned to sail during the school year are going on a sailing trip through the Caribbean – for no additional fees to the parents. I also heard that around this time Alpha began testing the 2-hour learning platform at a facility for juvenile delinquents in Florida. I heard that from one individual who was not directly involved and I have not found any written documentation on it, so unclear if it worked, it was a one off, or if it even happened. But it fits into the pattern of Alpha at this stage: “We know this program works for a specific type of kid. Let’s find out how broadly it is applicable. Can it work for everyone? Is it the solution for learning and education for the world?” Fall 2024 | “Pick‑Your‑Afternoon” Specialist Schools MacKenzie told me that there was consensus among the current parents of Alpha that the 2-hour learning program was exceptional and was making a huge difference with their kids. Their kids were all learning at breathtaking speed in a very condensed period of time. But there was NOT consensus about what the kids should be doing in the other 22-hours of the day. Some parents wanted to utilize the platform’s capabilities to go even faster. Some wanted their kids to just chill out and enjoy the rest of their day – let kids be kids. Others wanted their kids to use the freed up time to do sports, or study music. It was clear to her that “learn more faster in a short period of time” was a universal desire. But beyond that it was unclear what the “right” solution for the rest of her program was. You can make the morning ultra-personalized, but if the goal of the afternoon is socialization that you are missing in the morning, you need to have some sort of alignment on how to spend that afternoon. That challenge led to Alpha’s 2024 expansion into specialty schools. Three micro‑campuses opened August 2024: GT School (Georgetown, TX) — Alpha’s “Gifted and Talented” School. Higher admissions bar; higher academic expectations; Afternoon programming focused on excelling in “academic competitions” like chess, go, debate, public speaking, robotics, programming and Quiz Bowl.
2-hour Learning

2-hour Learning is a recurring organization in the Astral Codex Ten archive, appearing 1 times across 1 issues between June 27, 2025 and June 27, 2025. The archive places it in contexts such as "Alpha now had a parent company, “ 2-hour Learning ”". It most often appears alongside 10,000 hour rule, 2 Hour Learning, Inc, Alex Amplifier.

Reference entry
2-hour Learning
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1
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1
First seen
June 27, 2025
Last seen
June 27, 2025
June 27, 2025 · Original source
2-Hour Learning’s flagship school is the “Alpha School” in Austin Texas. The Alpha homepage makes three claims:
Same state curriculum, same worksheets, same pace. The school philosophy was “no acceleration—just go deep.” We knew this was the philosophy going in. The pitch was that instead of accelerating through the state curriculum the teachers would take their time with the kids and allow them to fully explore and master the content of each grade. When we asked for examples of what that meant in practice we were told things like: “Instead of reading more advanced vocabulary, the students will learn to read out loud and use emotion and character impressions. They will learn how to vary the timing of their reading like where and when to pause to create emotion in the listener”. That sounded reasonable! It sounded like more learning, but just different learning than what the state had mandated. In practice that was not what happened. In practice “deep” just meant “un‑measured.” Smart kids + small classes ≠ accountability. The kids had time to do music, lego building, theatre and Friday ski trips because they were all really bright. They didn’t need 6+ hours a day to learn the limited math required by the state, and since the school did not feel the need to advance faster than the state, there was no pressure to push learning at all – on anything really. There was no overall school curriculum. Every teacher did their own thing. While one first grade class had weekly spelling bees, the teacher in the other classroom did not believe in learning spelling at all. But it didn’t matter. The metrics they measured the kids on in both classes advanced “enough” that no one was concerned. Most time wasn’t spent on math or language anyway. Beyond the brochure activities like skiing and theater and the four hours of foreign language per week they split between Spanish and Mandarin (which was really a great opportunity for the kids who already spoke Spanish and Mandarin to have their egos flattered. I did not see any learning in either language class. I don’t see how you can teach a language a couple of hours a week to a group of 18 kids with skill levels from zero to fluency and expect to have any impact), a lot of time was spent on DEI. DEI was pitched as helping kids handle the emotions that often come from being sensitive gifted children (they called it “Synapse”). In practice my oldest daughter got four years of learning about the basic ideas of Martin Luther King Junior and Rosa Parks, a rough understanding that some people are non-binary, and a great deal of anxiety every time I left the water running while I was brushing my teeth. The talent drain In Spring 2024 the “intermediate-school” head resigned, as did the 40+ year veteran science teacher we had been looking forward to our daughter having, the beloved tech teacher who had built a her own proprietary “learn to type” software, plus half the lower‑school faculty. Our oldest was going to be entering fourth grade; her incoming roster read like a rebuilding year for a professional sports team. It was possible we could get her into a middle school that would feed into a top tier high school, but those did not start until 5th grade. Our best option looked like “suck it up and accept whatever we had for at least a year”. One option was to do something radical. We considered taking a GAP year and traveling the world with an organization called “Boundless” but decided the timing wasn’t right. Earlier in the year we had started exploring moving to the charter city of Prospera. There is a Montessori school there that seemed like it might be alright. And we could surround the kids with an interesting group of people (and live on the beach!). But by the spring we had ruled it out. There did not seem to be many families as part of the community and we were not comfortable with the risk profile based on what was happening with the conflict between Honduras and their charter cities. Then I stumbled across Alpha: Two‑hour mornings, life‑skills afternoons, claims of 2x learning. Marketing copy is cheap; still, the promise was different enough to warrant due diligence. The initial plan was to fly some of the kids to Austin for an Alpha summer camp for a week in June – just to try it out. But once we started exploring more my wife asked me: “Could we actually move to Austin and try it for a year? Based on what is happening at the kids' school, this might be the year to try it.” So over eight weeks we flew to Austin five times – conversations with admissions and school heads, real estate searches, kids doing shadow‑days. Every parent we spoke to was very impressed with the school. Their kids really were advancing at 2x+ speed – and no one believed it was just a “selection effect”. And every guide I spoke to was extremely impressive themselves. They reminded me of the staff you run into when visiting Disney World. They all seemed “full faced” and fully-engaged. When I asked the head of admissions how they found such good staff he told me their compensation was fully transparent. “Associate Guides” were paid $60,000/year (vs the $40,000 average for Austin teachers), “Full Guides” made $100,000 and the five “Head Guides” in the school each made $150,000. They were able to both poach the best teachers from other schools, but also bring exceptional people into teaching that would not have considered it otherwise. It also let them have very high expectations for teachers once they were hired. We pulled the trigger in July. New house. Admissions letter signed. Moving truck (plus car-mover) scheduled for October. Worst case, it would be a one‑year sabbatical from stagnation. The hypothesis I carried south Elite private school attendance buys you smaller classes, brighter kids, and fancier field trips – not academic acceleration. If Alpha was real, we’d see that differential, measurable impact by Christmas – that was when we would need to decide if we would cut bait and re-apply to schools back home (and sign the kids up for more IQ-tests. The school would not accept old ones). That prior—show me velocity, not polish—is the lens through which the rest of this review should be read. Part Two: A History of Alpha Note: This is my best attempt at piecing together the history of the school based on conversations with co‑founder MacKenzie Price, high school head Chris Locke, Alpha staff, and Alpha parents; All dates are estimates and I am SURE I have gotten some details wrong. I will come back after the fact in the comments and make corrections as I hear from the people involved with corrections. 2013 – 2017 | Garage‑School to “Alpha” MacKenzie Price, then a mortgage broker in Austin, wasn’t impressed by the city’s gifted programs. She invited a small number of neighbourhood kids (including her two) into a makeshift microschool that ran two intense, teacher‑led academic “sprints” each morning, then “life‑skills” projects after lunch. Joe Liemandt — Founder of Trinity Technology, ESW Capital billionaire and family friend (MacKenzie’s husband worked for him) — kept his own children in conventional private school until he saw the qualitative improvement in the life skills of MacKenzie’s kids. He decided he wanted his kids to join MacKenzie’s but he wanted to take the project to the next level. Sometime around 2014-2017 he joined MacKenzie as a co-founder and started writing checks. Alpha recruited more students and guides and the operation jumped from location-to-location looking for a larger permanent home. 2017 – 2020 | K-8 Expansion and 2-hour focus Alpha grew to roughly 90 students from K‑8 and stabilized. Morning “core blocks” were still teacher‑driven (20‑minute bursts, 5‑minute breaks, rinse, repeat), but focused on students engaged in exercises with rapid feedback (not lectures). Afternoon workshops covered “life skills” like how to give and receive feedback or public speaking. I have not seen academic data from this time period, but when I spoke to Chris Locke, head of Alpha’s high school (which launched around 2020), he told me the kids coming into his 9th grade program were “fine,” academically – it was their life skills, confidence, and ability to engage with adults and their peers were exceptional. At this stage no AI, no dashboard, no 2x learning, no portal — just better ratios and focused pacing and the result was well balanced kids who were enjoying their education experience (even if they were unexceptional academically). 2020 – 2022 | Platform Era Begins Somewhere along the way Liemandt hired a small engineering team to stitch together edtech learning tools. Many schools use tools like iXL, Beast Academy and Amira. Those tools fit in well with the 2-hour structured approach Alpha was using. The “platform” Liemandt’s team built was meant as a tool to free up guide time so that students could be more self-directed. The dev team stitched together the preferred off‑the‑shelf apps behind a single login, and built out tracking and dashboards so guides (and students) could easily see how they were progressing. This also gave the curriculum team (there was a curriculum team now) data to understand where students were spending their time, what tools were working, and which weren’t as effective. The Alpha Portal was born. Not only did it increase efficiency, it provided data to iterate with. Chris Locke saw the curve change incrementally: each new cohort of ninth‑graders under the new tech-enabled learning platform came in a little stronger academically. The “life skills” were now being matched by the “academic skills”. 2022 | Expansion and Iteration By having access to Alpha kids post-graduation in the high school, Locke could send feedback back to the elementary school.The kids coming out of the new program were now killing it academically on Math, Language, and Science, but they were still weak on things like History and Geography. He fed that type of information back to the curriculum designers, who iterated and improved the program. Soon, in addition to the core platform that directed students to third-party tools, the tech team was building proprietary “Alpha” tools themselves. The flagship of the in-house tools was “AlphaReads”. AlphaReads requires students to read progressively more complicated passages, followed by answering reading comprehension questions. In addition to helping the kids improve reading skills, Alpha uses it to push types of content. Instead of classes in history, geography, economics and political science, some of the reading passages will cover that material (in addition to learning how to read and understand Shakespeare and Proust). The success of the 2-hour learning platform was giving the Alpha founders confidence. Liemandt in particular wanted to see if the program had legs beyond the elite group of students being educated in Austin. Alpha’s first external test in August 2022 in Brownsville, TX – a small community on the Mexico border with less than half the per capita income of Austin. SpaceX had recently launched Starbase in Brownsville in 2014 and the employees there were not happy with the existing school options. Someone at SpaceX approached Alpha and asked if they could launch a new campus for their employees. It is unclear if any money changed hands, but when Alpha launched their Brownsville campus (available to SpaceX employees and any other locals who are interested) tuition was only $10,000 (vs $40,000 at the main Austin campus); incoming students trailed national academic standards by over a year. But after nine months on the Alpha program the first cohort of students had caught up and surpassed the national average, and they kept accelerating, achieving an average learning velocity of ~2× the national average (see section four for what that means). Brownsville was Alpha’s attempt to show that their model wasn’t just rich‑kid selection effects. Spring 2024 | Field Pilots & Ukraine Trip Alpha tuition is high for the Austin area ($40,000 vs average private school ~$10,000-$15,000), but unlike most private schools tuition is all-inclusive. There are no extra fees for computers or field trips. There are no silent auctions or appeals for donations. This “no extra fees” allows the school to do some pretty ridiculous things. In the first half of 2024 Alpha sent a group of students to Poland to help launch a 2-hour learning pilot among Ukrainian refugees. Students did not pay to go on the trip. But students also did not have a “right” to go on the trip. They had to earn it. In addition to being on top of academic and non-academic expectations, students who wanted to participate had to learn basic Ukrainian so they could interact with the students in Poland they were meant to be helping. By not linking the opportunity to payment, the school could instead link it to behavior and achievement. This year a group of kids who learned to sail during the school year are going on a sailing trip through the Caribbean – for no additional fees to the parents. I also heard that around this time Alpha began testing the 2-hour learning platform at a facility for juvenile delinquents in Florida. I heard that from one individual who was not directly involved and I have not found any written documentation on it, so unclear if it worked, it was a one off, or if it even happened. But it fits into the pattern of Alpha at this stage: “We know this program works for a specific type of kid. Let’s find out how broadly it is applicable. Can it work for everyone? Is it the solution for learning and education for the world?” Fall 2024 | “Pick‑Your‑Afternoon” Specialist Schools MacKenzie told me that there was consensus among the current parents of Alpha that the 2-hour learning program was exceptional and was making a huge difference with their kids. Their kids were all learning at breathtaking speed in a very condensed period of time. But there was NOT consensus about what the kids should be doing in the other 22-hours of the day. Some parents wanted to utilize the platform’s capabilities to go even faster. Some wanted their kids to just chill out and enjoy the rest of their day – let kids be kids. Others wanted their kids to use the freed up time to do sports, or study music. It was clear to her that “learn more faster in a short period of time” was a universal desire. But beyond that it was unclear what the “right” solution for the rest of her program was. You can make the morning ultra-personalized, but if the goal of the afternoon is socialization that you are missing in the morning, you need to have some sort of alignment on how to spend that afternoon. That challenge led to Alpha’s 2024 expansion into specialty schools. Three micro‑campuses opened August 2024: GT School (Georgetown, TX) — Alpha’s “Gifted and Talented” School. Higher admissions bar; higher academic expectations; Afternoon programming focused on excelling in “academic competitions” like chess, go, debate, public speaking, robotics, programming and Quiz Bowl.
NextGen Academy (Austin) —Perhaps the most radical experiment. Afternoons are spent training in competitive esports & game design. Each new campus launched with <10 students, two or more local guides, and the same two‑hour core. Simultaneously Alpha opened a Miami elementary campus, promoted the idea that cities could launch “micro schools” if they had enough local demand (unless you count Miami, none actually launched) and piloted a beta-test of a Home‑School version of the platform. Early homeschool data showed that kids were using it for ~2 hours/day as planned, but only seeing a 1x learning growth — still a fine result for only doing 2-hours of academics per day, but a long way from what Alpha was delivering on their own campuses, so the program has stayed in beta. Jan 2025 | Charter & Licence Play Alpha now had a parent company, “2-hour Learning”, which sat above all of the schools, the home school product, and the platform itself (that they now offer to license out to third parties). The parent company filed under “Unbound Academy” to launch charter schools in Arizona and Pennsylvania. The Pennsylvania school was rejected, but the Arizona school will launch in fall 2025. There are more applications pending in at least Utah, Arkansa, North Carolina, South Carolina (and likely more). While the PR spin around these schools is “AI-driven, no teachers” in practice they use 20:1 teacher guide:student ratios (vs the 5:1 ratio at the Alpha private schools) Generally states subsidize charter schools in the neighborhood of $10,000 per student – which is a lot lower than what Alpha charges. They should be able to make those economics work by using fewer, less expensive teachers, not having an expensive campus (or no campus at all for the online schools), skimming on the extras (no trips to Poland), avoiding teaching the youngest kids (Arizona is 4th-8th grade), and being willing to accept smaller or even negligible margin on their learning platform. The goal of these schools does not seem to be making money or profit – at least not right away. The goal seems to be rapidly expanding the program to have more influence, and to see if they can make it work with “non-selected kids at a low price point”. Fall 2025 and Beyond | The Future The Alpha website claims the following locations are launching in Fall 2025: Houston, TX
20th Century Fox

20th Century Fox is a recurring organization in the Astral Codex Ten archive, appearing 1 times across 1 issues between August 16, 2024 and August 16, 2024. The archive places it in contexts such as ""Marvel sold the film rights of X-men and mutants to 20th century Fox"". It most often appears alongside Abomination, Abomination, Abraham Lincoln.

Reference entry
20th Century Fox
Mention count
1
Issue count
1
First seen
August 16, 2024
Last seen
August 16, 2024
August 16, 2024 · Original source
Given Marvel Comics, why Silver Age (1961-1965)? I.a. Why Superhero Comic Books? The winner of last year’s Astral Codex Ten book review contest was Brandon Hendrickson. Brandon wrote about Kieran Egan’s The Educated Mind. One of the foundations of Egan’s educational philosophy is that people learn through stories. He believes early education should focus on teaching lessons through myths and legends. This matches my experience. My kids’ favorite podcast is Greeking Out – a very well produced, very entertaining, National Geographic podcast about Greek Legends. Aside #1: When my oldest daughter was three years old she would ask everyone she met “Do you know any myths? Can you tell me a myth?” She especially liked asking people from different places to get myths from their local cultures. Once, she asked the question to a friend of mine who grew up in South Africa, “Can you tell me any South African myths?” He struggled for a minute and then said, “Okay! I have one! Bread never falls butter side down!”. That was not the type of myth she was looking for; nor the type of myth we will be discussing in this review. Every culture has foundational myths. These stories are entertaining and engaging, but they also teach valuable lessons about both what is important in that culture, and how people in that culture are expected to behave (or at least the Platonic Ideal of how they should behave). In the modern, Western world, we have assimilated many of these foundational stories, particularly the Greek myths. My kids definitely know the Greek myths, but they also know elements of Norse mythology, Egyptian myths, stories about Anasi from West Africa and more. More fundamentally my wife and I, while not religious ourselves, have made a point of exposing the kids to the stories from the Bible. It is not politically correct to call Biblical stories “myths”, but they serve the same purpose – shared cultural understanding of the way the world works. My wife grew up without any religion, and when she was in high school, she struggled with the metaphors and religious allegories that were omnipresent in most of the Western canon. In our culture, familiarity with the Bible is important for an educated person – whether they are religious or not – because it is the foundation of so much of the rest of our culture. I believe the other set of mythological stories that are foundational to our culture are – and by this point I am sure you see where I am going here – comic book superheroes. If true, then having more than a surface-level understanding of the most important superhero stories is important in a similar way to that knowing the Bible stories is important. “Do unto others as you would have them do unto you” is an important idea to understand. So is, “With great power comes great responsibility”. I.b. Why Marvel? While there are many independent superheroes that are not owned by major conglomerates, the superheroes who have built our modern foundational myths are currently owned by two corporations. Warner Bros. Discover owns the DC library of superheroes including Superman, Batman and Wonder Woman. In 2009 Disney purchased Marvel Comics and took ownership of their characters, including Spiderman, X-men and the Avengers. Aside #2: Marvel has sold temporary film rights to many of their characters over the years. The most relevant sales started in 1994 when Marvel sold the film rights of X-men and mutants to 20th century Fox, then in 1996, when Marvel went bankrupt, Fox picked up the rights to the Fantastic Four (and New Line picked up Blade). In 1999 Marvel sold the film rights (and live action TV, and animated TV longer than 44 minutes) of Spider-man and related characters to Columbia Pictures (part of Sony) for $7MM. Marvel actually attempted to sell ALL of their remaining Marvel IP film rights to Sony for $25MM, but the top management at Sony was not interested. Sony’s management allegedly told their chief negotiator “Nobody gives a shi*t about any of the other Marvel characters. Go back and do a deal for only Spider-Man). Disney acquired Marvel in 2009, and then Fox in 2019, bringing the two separated packages of characters all back together under one roof (Blade reverted back to Marvel in 2012). Sony still owns the rights to Spider-man but has made a deal with Disney to include some of his films within the Marvel-Disney universe. Marvel sold the film rights of The Hulk to Universal in 1990 and the current status of that agreement is complicated (the consensus is that Marvel now controls the film rights to the character, but Universal owns distribution rights to any stand-alone Hulk film, which could be why Disney let's Hulk co-star in Thor movies, but not vice versa). In the early aughts Marvel wanted to build their own film franchise, but were limited to only using their remaining “B-list” characters – Spider-man, X-men, and the Fantastic Four were all off limits. Fortunately, Kevin Feige, president of production for Marvel at the time, saw a way forward. He convinced Ike Perlmutter, Marvel CEO, to allow for the production of a series of films with the remaining characters begining with Iron Man (2008). Jon Favreau directed and cast Robert Downey Jr as Tony Stark. The film blew away expectations. Kevin’s plan of a series of movies where the characters would interconnect was suddenly feasible. Iron Man was followed by The Incredible Hulk, Thor, and Captain America: The First Avenger. None managed the box office magic of Iron Man, but all were successful enough that the plan stayed on track. In 2012 the characters were all brought together in the first Avengers film, which opened to over $200MM domestically and went on to gross more than $1.5B (which made it the 3rd highest grossing film of all time). Marvel became the first studio to take the interconnected world of their comic books and make the model work on the big screen (for a much larger audience). Once the model was proven to work, other studios tried to duplicate it. Aside #3: Warner Bros’ stumbles with the DC shared universe of Batman, Superman and the Justice League are well known, but that was actually their SECOND attempt at a shared universe. Their first attempt tried to copy the Marvel method more closely. They chose their own B-list hero and set up his first film to allow for a wider mythology. Alas Green Lantern (2011) failed at the box office and we never got stand-alone films about Sinestro (Yellow Lantern), Carol Ferris (Star Sapphire, the Violet Lantern), John Stewart (African American Green Lantern), Kyle Rayner (1990s Green Lantern), Alan Scott (original Green Lantern), or the Blue, Red, and Orange Lantern Corps. At least so far, no studio has successfully created anything with close to the traction obtained by the Marvel Cinematic Universe (MCU). Warner’s DC Extended universe (DCEU) had trifling success, but is being shelved and rebooted for a fresh attempt next year. Universal’s attempt at a “Dark Universe” kicked off with Tom Cruise in The Mummy (2017), but was dead on arrival. Paramount’s attempt to link the Transformers Universe to GI Joe at the end of Transformers: Rise of the Beasts has been appropriately mocked. Sony’s Spider-man films linked to the MCU have been very successful, but their attempt at a stand-alone non-MCU Spider-man universe using Spider-man’s villains as anti-heroes has floundered (mostly succeeding only as a source of memes). Next Mattel will be attempting to build a universe off the success of last year’s Barbie and may include Polly Pocket, American Girl, Hot Wheels, and He-Man and the Masters of the Universe (no word yet on Thomas the Tank Engine, View Master and the Magic-8 Ball, but all are apparently in development). To date, only Marvel has successfully built a “Cinematic Universe”. One potential reason for the MCU’s success is that Kevin Feige built his cinematic universe on the back of the existing interconnected universe of the comics. But those comics were not the first interconnected universe of stories. For that we would need to go back to our foundational myths. The Bible stories mostly interconnect. Adam and Eve flows into Cain and Abel. David and Goliath leads to the Wisdom of Solomon. Greek Myths DEFINITELY interconnect. Supporting characters in one Greek myth have starring roles in their own stories. The Greek pantheon of tales even have their own version of the Avengers. In the Quest for the Golden Fleece, Jason brings together the Argonauts, who included in their number Theseus (who defeated the Minotaur), Orpheus (who braved the underworld) and Hercules himself – all A-list stars in their own “franchises”. Stand alone stories that exist within an interconnected universe are rare in modern media but were common in the ancient myths that have stood the test of time. Only Marvel has successfully created a shared universe that follows the pattern of ancient myths. Only Marvel films have stand-alone stories and protagonists who exist together in an interconnected world. Something about that method of storytelling is deeply pleasing for humans across many cultures. Marvel films are the first and most successful modern version of the mythological universe, and that it is worth spending more time exploring Marvel’s underlying mythology and where it came from. I.c. Why 1961? The origins of Christianity and Judaism (and Buddhism and Hinduism) are very murky. Even Islam is far enough in the past that we only have a very rough understanding of how it came to exist. When scholars want to understand in detail how a new religion is born they are far better to look at Mormonism or, if you accept it as a religion, Dianetics. Similarly, we have versions of Greek myths that have been passed down to us, but we can never know how those myths changed from their first telling to their “final” versions. Were the stories once unrelated, and only later became crafted into a single “universe”? Or were the stories built off each other one by one (“Dad that Golden Fleece story was amazing! Do you know any other stories about the Hercules guy?”)? Or was it something in between? Perhaps the stories all existed independently, but were later crafted together (“Remember that 12-labors story I told you? Actually that was the same guy who was on the Argo!”) Unlike Greek legends, we can know the origin of the Marvel Universe. We can see how it was constructed step-by-step. The people who did it (most importantly Stan Lee, Jack Kirby, and Steve Ditko) are dead now, but they have not been dead for long. We can read the original work, see how it changed over the last 60 years, and we can ask the creators “what were you thinking at the time” (or at least read their answers from old interviews). We can’t always trust what Stan Lee says, but at least we can hear his point of view. No one has a transcript of an interview with Homer, or knows exactly what he was thinking when he called it the “wine-dark sea”. Tl;dr: Why read about Marvel Comic superheroes 1961-1965? Because interconnected mythological stories are very important to cultures, Marvel is the leading contender of the most recent modern mythology, and it originated in the first half-decade of the 1960s. II. How did Marvel Superhero Comics happen? Timely Comics published their first comic book in 1939 and called it “Marvel Comics”. Their most popular World War II comics included Captain America, the Human Torch (an android unrelated to the modern Human Torch except in powers, appearance and name), and Namor, the Submariner. In the early 1950s superheroes became less popular, so Timely changed its name to Atlas Comics and focused on humor, western, horror, war and science fiction stories. But in 1956 DC Comics began re-introducing their Golden Age superheroes and, in the second half of the 1950s, the genre took off again – particularly Superman, whose title, Action Comics, became the number one selling comic in America. Stan Lee, editor and chief at Atlas at the time, wanted to get in on the superhero action. Unfortunately in 1957 Atlas lost its distributor and the company had to rely on “Independent News” to get its comics on newsstands. The complication was that Independent News was owned by “National Periodical Publications”, who also owned DC-comics and did not want Atlas to introduce superheroes to compete with Superman, Green Lantern and the Flash. Independent News agreed to distribute Atlas comics but limited the publisher to eight titles per month, and only in non-super hero genres (like horror, romance and science fiction). Blocked from creating and launching new superhero titles, Stan Lee got creative, and in August 1961 Atlas Comics published Fantastic Four #1. Aside #4: Fantastic Four #1 was on newsstands in August 8th, 1961, but the date on the cover was November 1961. The convention at the time was that the cover date was not the “publication date” but rather the “pull date”. The pull date was the time when the retailer could send back unsold copies back to the publisher for a refund. In fact the retailer did not need to send the entire issue back, just the cover, as it was assumed that comic books could not be sold without the cover, and it saved on postage. This was only relevant because it was great for my dad who was a child at the time. My dad was friends with the kid whose father owed the local pharmacy which meant he had access to every comic book published in the late 1950s as long as he was willing to wait a few months and read it without a cover. Going forward in this essay I will always use the pull dates rather than the publication dates for individual comic book issues as they are far easier to source. If you want to convert pull dates back into publication dates you can subtract roughly two months, but it is inconsistent and sometimes longer, as was the case with Fantastic Four #1. Check out the cover of Fantastic Four #1: To the modern eye this certainly looks like a superhero comic. Four heroes with super powers fighting a giant monster. But in the eyes of publishers in 1961 this looked more like a science fiction adventure comic than something that would go head to head with Superman. Here are the covers of Action Comics (the best selling superhero comic at the time) from the three months leading up to Fantastic Four #1: Notice what they have in common? “Super Rivals”, “Super revenge”, “Super Substitutes”. And all include Superman in his blue and red tights. Fantastic Four’s cover featured super powers, but never used the word “super” and no one was wearing superhero costumes. Fantastic Four, as a superhero story, slipped under the radar because it wasn’t really a superhero story at all. It was a story about four close friends who attempted to fly into space, but then something goes wrong and they crash back to Earth. The experience changes them and they decide they now need to use their new abilities to help the rest of humanity – specifically against monsters who are invading from under the Earth. It is a fantastical science fiction story – not a superhero story. Later in his career Jack Kirby, the illustrator of the issue and co-creator of the Fantastic Four, was asked about his inspiration for the Fantastic Four heroes. He did NOT say Superman – or any superhero. He said Challengers of the Unknown. Challengers of the Unknown was an adventure story co-created by Kirby in Showcase #6 in February 1957. Here is how Wikipedia describes the Challengers origin: When acquaintances miraculously survive a plane crash unscathed, they conclude that since they are "living on borrowed time" they should band together for hazardous adventures. The four—pilot Kyle "Ace" Morgan, daredevil Matthew "Red" Ryan, strong and slow-witted Leslie "Rocky" Davis, and scientist Walter Mark "Prof" Haley—became the Challengers of the Unknown. Showcase #6, and the first appearance of the Challengers of the Unknown, by Jack Kirby Visually the Challengers and the Fantastic Four were similar. Both wore skin tight uniforms with belts and minimal decoration. The Fantastic Four’s relatively simple characterizations were practically pulled from Challengers. Reed takes on the traits of both Kyle, the leader, and Walter, the scientist. Johnny, the Human Torch is the daredevil. The Thing is “strong and slow-witted”. Sue, the only woman on the team, seems like a new addition, but is likely based on June Robbins who joined the Challengers team in Showcase #7, as an “honorary” or “girl-Challenger”. After surviving their respective “miraculous” crashes, both the Challengers and the Fantastic Four band together to help the world. They both travel through space and other dimensions, fighting mad scientists and monsters. The Fantastic Four’s early antagonists were not traditional super villains. In the first few issues they fight monsters from under the Earth (Issue #1), shape changing aliens (#2), and a charlatan who uses hypnotism to steal from his audience (#3). In issue #4 Kirby and Lee re-introduce Namor, the Submariner, one of Marvel’s top IP from the 1940s, and have him kidnap Sue. Only in Issue #5 and #6 (June and August 1962) and do we get a more standard-supervillain when Dr Doom attempts to steal the Fantastic Four headquarters and throw it into space. The next superhero Lee created was even less heroic than the Fantastic Four. In April 1962 (pull date), Marvel published The Incredible Hulk. If it was even a superhero story in disguise it was a very good disguise. The story was a scientific-filtered version of Dr Jekyl and Mr Hyde. It was a pure monster-story with nothing very super about it. Nothing on the cover suggests this has anything to do with superheroes: It is not clear if even Lee at the time thought the Hulk would be a superhero. In Fantastic Four #5 Johnny is reading a “great new comic mag” and mocks the Thing by comparing him to the Hulk. It seems pretty clear at this point that in the Fantastic Four’s world, the Hulk is just a fictional comic book, like in ours (more on that later): The other two superheroes the Marvel introduces in this period have even more subtle introductions. At the time Marvel had a number of generic-sounding titles and told science fiction and fantasy stand-alone stories: Tales to Astonish
pol

4chan /pol/ is a recurring organization in the Astral Codex Ten archive, appearing 1 times across 1 issues between May 18, 2021 and May 18, 2021. The archive places it in contexts such as "/pol/ have always been far right. What really changed is /pol/ becoming by far the most active board on 4chan". It most often appears alongside #BLM, /b/, /sp/.

Reference entry
pol
Mention count
1
Issue count
1
First seen
May 18, 2021
Last seen
May 18, 2021
May 18, 2021 · Original source
new/ (the /pol/ predecessor) and /pol/ have always been far right. What really changed is /pol/ becoming by far the most active board on 4chan ( that and /b/ losing relevance and not having stuff like Project Chanology anymore). I don't feel like non-political boards like /sp/ have changed much in tone in the last +10 years.
4o

4o is a recurring organization in the Astral Codex Ten archive, appearing 1 times across 1 issues between July 08, 2025 and July 08, 2025. The archive places it in contexts such as "4o just works". It most often appears alongside ACX Prediction Contest, AI, Askwho.

Reference entry
4o
Mention count
1
Issue count
1
First seen
July 08, 2025
Last seen
July 08, 2025
July 08, 2025 · Original source
Not only is this 5/5, but it’s an obvious step up in matching the styles, and these were all produced on the first try. In retrospect, it feels like judges were right to dismiss former models, which were sort of blundering about and getting some of them right by coincidence. 4o just works.
5calls.org

5calls.org is a recurring organization in the Astral Codex Ten archive, appearing 1 times across 1 issues between December 29, 2025 and December 29, 2025. The archive places it in contexts such as "go to 5calls.org, pick the first random issue on their list". It most often appears alongside A Call For New Aesthetics, ACX, Astralcodexten Com.

Reference entry
5calls.org
Mention count
1
Issue count
1
First seen
December 29, 2025
Last seen
December 29, 2025
December 29, 2025 · Original source
And a reader writes in to say that if you’re an American concerned about chip exports, you might want to call your senator. To reduce friction as much as possible, he gives a potential script - go to 5calls.org, pick the first random issue on their list, ignore their suggested script, and paste this instead:
7o2wzrybd[at]mozmail[dot]com

7o2wzrybd[at]mozmail[dot]com is a recurring organization in the Astral Codex Ten archive, appearing 1 times across 1 issues between August 25, 2023 and August 25, 2023. The archive places it in contexts such as "Contact Info: 7o2wzrybd[at]mozmail[dot]com". It most often appears alongside "El Retiro" Park, 11841 Wagner Street Culver City, 1548 NE 15th Ave.

Mention count
1
Issue count
1
First seen
August 25, 2023
Last seen
August 25, 2023
August 25, 2023 · Original source
ANCHORAGE, ALASKA, USA Contact: Matthew Contact Info: 7o2wzrybd[at]mozmail[dot]com Time: Sunday, October 29th, 1:00 PM Location: The Writer's Block Bookstore & Cafe, 3956 Spenard Rd, Anchorage, AK 99517. I'll be wearing a green pullover and have a small sign on the table saying ACX MEETUP Coordinates: https://plus.codes/93HG53MF+QG Notes: Please RSVP using my provided email, so that I know what I should prepare for!