American

Article

American is a recurring place in the Astral Codex Ten archive, appearing 12 times across 12 issues between February 18, 2021 and December 10, 2025. The archive places it in contexts such as “rather than children of more favored demographics (‘races’ to an American)”; “American wheat strains”; “Maybe Japanese and American?“. It most often appears alongside China, France, Germany.

Metadata

• Category: Places
• Mention count: 12
• Issue count: 12
• First seen: February 18, 2021
• Last seen: December 10, 2025

Appears In

• Highlights From The Comments On Cult Of Smart
• Your Book Review: The Wizard And The Prophet
• Your Book Review: Humankind
• Highlights From The Comments On Missing School
• Highlights From The Comments On Health Care Systems
• Ukraine Warcasting
• Response To Alexandros Contra Me On Ivermectin
• The Question Of Separatism
• Your Book Review: The Laws of Trading
• Your Book Review: The Family That Couldn’t Sleep
• Your Book Review: How the War Was Won
• Links For December 2025

Related Pages

• • China (5 shared issues)
• • France (5 shared issues)
• • Germany (5 shared issues)
• • Scott (5 shared issues)
• • America (4 shared issues)
• • Australia (4 shared issues)
• • Britain (4 shared issues)
• • COVID (4 shared issues)
• • Europe (4 shared issues)
• • India (4 shared issues)
• • Israel (4 shared issues)
• • Substack (4 shared issues)

External Links

• • http://web.archive.org/web/20221104130431/https://stevekirsch.substack.com/p/1m-bet-rules
• • http://web.archive.org/web/20221129133112/https://blog.rootclaim.com/rootclaim-accepts-500000-challenge-on-covid-vaccine-safety-efficacy/
• • http://web.archive.org/web/20221224061743/https://www.skirsch.com/covid/SaarWilf.pdf
• • http://www.amlecon.org/
• • https://3cgroup.global/
• • https://academic.oup.com/aje/article/154/4/357/62015
• • https://amzn.to/3wsUsS6
• • https://api.isr.umich.edu/wp-content/uploads/2023/07/Initial-Eclipse-Viewing-Report.pdf
• • https://archive.ph/pY4gF#selection-663.103-683.190
• • https://astralcodexten.substack.com/p/your-book-review-njals-saga/comment/17401109
• • https://docs.cdn.yougov.com/crjq3mojm5/toplines_Views%20on%20Britain%20and%20the%20Monarchy.pdf
• • https://drive.google.com/file/d/1aHlhPd-16EOabzXhiajT5PBm3uVCAG3T/view

Source Context

Recovered passages from the original issue text. When the raw archive preserved outbound links inside the source passage, they are listed directly under the quote.

Highlights From The Comments On Cult Of Smart

February 18, 2021 · Original source

More importantly, I learned how to get bullies in trouble with the powers that be, how to figure out what answer was wanted and give that, rather than blurting out the truth, and how to manipulate authorities into doing what I wanted. Very useful skills, though I'd rather not have had to learn them by experimenting on the guards (teachers), trustees (prefects), and fellow prisoners (students). And I had so much better an experience than the one my government chose to inflict on those who'd committed the crime of being native Canadian children, rather than children of more favored demographics ("races" to an American). And then there were the unfortunate children who wound up in the care of social services. They were probably better off than the native children, but not always, and not by much.

I actually spent a year as a public school teacher (in Japan, but their system is a lot like America’s). I agree with jmk's critique - I briefly tried funner, more freeform lessons, failed, and then did more or less the same thing as everyone else.

Your Book Review: The Wizard And The Prophet

April 30, 2021 · Original source

The fact that Vogt’s first entry into the public sphere is rallying the public against anti-malaria measures leaves a pretty bad taste in my mouth, as I’m sure it does for any of Mann’s Effective Altruist aligned readers. It would be one thing if Vogt were concerned about the detrimental impact of malaria on humans AND the detrimental impact of malaria prevention methods on bird life. But in subsequent chapters of Vogt’s biography, Mann goes out of his way to show that Vogt’s influences and contemporary members of the environmentalist milieu – for example, Madison Grant, co-founder of the Bronx Zoo, organizer of the United States national park system, and author of the charmingly named The Passing of the Great Race, beloved by Hitler – were, to put in mildly, extremely uninterested in the wellbeing of all humankind. Instead, they were obsessed by fears of an unchecked Malthusian population explosion, race mixing, and a resultant societal degeneration that could only be stopped by halting (read: starving out) population growth. Which people deserved to live in harmony with nature in the ensuing pastoral utopia and which would be relegated to the dustbin of history was not an exercise they left to the reader. Mann writes that Vogt, like his buddies, was "loudly scornful of the ‘unchecked spawning’ and ‘untrammeled copulation’ of ‘backward populations’ – people in India, he sneered, breed with ‘the irresponsibility of codfish.’"

Inline links: Madison Grant

In college, Borlaug first studies forestry, then gets seduced by plant biologist Elvin Charles Stakman’s personal crusade against stem rust, a fungus that blights wheat crops and, at the time, critically endangered the global wheat supply. After a brief stint as an industry research scientist at DuPont, in the 1940s Borlaug ends up as the unlikely candidate to lead a nascent rust study in Chapingo, Mexico. Borlaug is sent by his superiors essentially to sell the Mexican farmers on the more productive (but still rust-susceptible) American wheat strains. Instead, he takes the underfunded and under-resourced Chapingo project into an unexpected direction: after seeing that rust and variability in growing conditions would hamper any attempt to increase wheat crop yields in Mexico, he begins a series of years-long Mendelian cross-breeding pilots in four different locations of Mexico to find a prodigious, hardy wheat strain that is not only immune to rust, but can survive and thrive virtually no matter the location or growing conditions.

Inline links: Elvin Charles Stakman’s, stem rust

In "Water," again, the Wizards have a solid track record. The Wizardly California State Water Project transformed a desert into the most productive farmland and state in the nation; the National Water Carrier Project of Israel-Palestine made life in the Fertile Crescent possible for millions of Jewish refugees. Desalination projects (expensive, but with nearly bottomless potential, given how huge our oceans are) have de-escalated the fight for shrinking groundwater resources in California and the Middle East. In this arena, the Prophets have been a little more successful in offering alternative conservation-oriented solutions that have stuck: storm and wastewater reclamation, drip irrigation, and behavioral change campaigns to encourage more frugal water usage that have seeped (pun intended) so deeply into the public consciousness that running the tap while brushing your teeth feels as illicit as lighting up a cigarette. All of these measures do little, though, to solve the fundamental underlying problem of massive urban growth in water-scarce areas like the American Sunbelt; if anything, growing water efficiency among consumers exacerbates the problem by shrinking utility profits and forcing them to either cut back on much-needed infrastructure repair and service improvement or raise water costs. Conservation and reclamation can only do so much; they can’t provide water to the exploding populations of Arizona or Sub-Saharan Africa.

Inline links: California State Water Project, National Water Carrier Project, shrinking utility profits and forcing them to either cut back on much-needed infrastructure repair and service improvement or raise water costs

Your Book Review: Humankind

May 28, 2021 · Original source

This turned out not to be true. So spectacularly untrue that we still talk about the Blitz Spirit. With our trademark humility, the British concluded that this was due to our exceptional moral fibre and, with help from the Americans, set about bombing German civilians to hell and back. Regrettably the Germans too responded by pulling together, and working harder in the war effort. Literally no one thinks this was due to their exceptional moral fibre. Instead, it seemed that crisis led to teamwork. Bregman is able to quote similar behaviour on the Titanic, on September 11th and in the aftermath of Hurricane Katrina.

1% for today (not fighting world wars helps) But pre-historic man used things like tusks for weapons. This makes it hard to distinguish between 'violent death at the hands of the tribe down the road wielding tusks' and 'violent death at the hands of an elephant which didn't fancy being eaten for dinner'. Foraging tribes today are even less use - any tribe which has been followed around by sociologists with clipboards is hardly unsullied by contact with the modern world, and indeed quite a lot of the deaths turn out to have been caused by bullets from slave traders (presumably either these slave traders have developed zombification, or else they completely missed the aim of their job) or cattle ranchers. Unless Predator was actually a documentary, one presumes primitive man didn't have to contend with this. This is the issue with pre-history - it's pre … history. We really don't know that much about it. A hundred years ago G.K. Chesterton observed that we picture cavemen as stupid thugs dragging their clubs, but the one thing we actually know about them, was that they were artists. Having dispatched the notion that we can discern pre-history from primitive tribes today, Bregman then says we can tell primitive man was peaceful by observing his favourite primitive tribes today. He is even willing to infer the political views of our distant forebears based on the views held within those tribes. Sigh. Thankfully returning to history turns up some better evidence. In 1943 Colonel Samuel Marshall, the US Chief Combat Historian (you guys have the coolest titles) was with an American camp attacked by Japanese soldiers. The Japanese made 11 attempts in all, and were nearly successful despite being outnumbered. The next day Colonel Marshall tried to find out what went wrong. He interviewed the men in groups, asking them to speak freely and allowing them to disagree with their officers. What he discovered was that only 12% of the men fired their guns. Interviews in the Pacific and Europe broadly confirmed this picture: 15%-25% is typical. The majority of soldiers don't shoot at the enemy. They're not cowards, they don't run away. They just don't fire. Separate studies in the British and Soviet armies turned out the same conclusion. Muskets from the Battle of Gettysburg in the American Civil War (hey, you've been known to write 'Paris, France') found 90% were still loaded. Which is odd because loading a musket takes ages, 20 times as long as aiming and shooting it. Odder still is that half of them are double loaded. Not double shotted: double powder spaced out as well. This doesn't work. One of them has been loaded 23 times without firing. It's almost like most soldiers don't want to shoot the enemy, and loading your rifle is the perfect excuse for why you're not shooting. Far from being blood thirsty killers with a thin veneer of civilisation, humans have a deep aversion to killing in even the most desperate of situations. Part 2: Lies, damned lies and social psychology Why we ought to lock up the Stanford Prison Experiment The second most famous psychology experiment in history is the Stanford Prison experiment. Philip Zimbardo split a group of undergrads at random into prisoners and guards. The guards were left free to choose how they would manage the prisoners, and within days the whole thing had to be called off as it had descended into a sadistic torture camp. At least that's how Zimbardo has described it for the last 50 years. In fact, everything I just said is completely false. The undergrads were not split at random - the scheme had actually been dreamt up by an undergrad called David Jaffe who had run a previous experiment himself on abusing prisoners in a fake jail. He was carefully placed into the guards group. Nor were the guards left to choose their methods, instead they were briefed by Zimbardo and Jaffe that the purpose of the experiment (for which they were being well renumerated) was to see how people cracked under pressure. The experiment would be a failure unless they could put the prisoners under terrible stress. Even Douglas Korpi's prisoner breakdown on day two, which, captured on camera, became the cinematic face of the experiment, was a fake he put on after discovering he wouldn't be able to spend the time in jail revising, and being told he would only be allowed to quit if he suffered some sort of serious mental or physical breakdown. Despite the pressure from Zimbardo and Jaffe, two thirds of the guards refused to take part in sadistic games, and much to their frustration a third continued to treat the prisoners with kindness. Nonetheless when Zimbardo came to write up the experiment about the effects on the prisoners, he realised it would be a much more compelling story if he turned it on its head, and made it about the guards instead. The truth of guards carefully drilled to be sadistic was swept away with a lie of ordinary people spontaneously becoming cruel when dressed in a uniform and given a position of power. For years no one replicated the experiment - given the results first time round it was thought unethical, but in 2001 the BBC in search of new reality television commissioned a repeat (turns out reality television runs to different ethics than the average psychology department). Now unlike normal reality TV they didn't bother manipulating the participants to be at each other's throats - there was no need, in days it was going to be a bloodbath. The result is the four most boring hours of television ever recorded. Nothing happens. The guards sit around chatting. When tensions arise with the prisoners, they defuse them by talking to them nicely. On day 6 some prisoners escaped. They headed over to the guards' canteen and all had a smoke together. On day 7 they voted in favour of turning the whole thing into a commune. Why we ought to be shocked by Milgram's shock machine So much for the second most famous psychology experiment, what about the most famous - Milgram's shock machine? Milgram experiment took pairs of volunteers, and assigned one to take a memory test, while the other administered electric shocks for wrong answers. The shocks start at 15V, with the 'shocker' instructed to raise it by 15V for each subsequent wrong answer, even beyond the danger label the machine has. As the voltage got higher the man taking the test would scream in agony. If the 'shocker' continued, then at 350V he would thump on the wall, and then go silent. Of course this wasn't actually an experiment on memory. The man taking the test was a member of Milgram's team, and there were no shocks, only acting. The point of the experiment was to find out how many people would electrocute a stranger, just because a man in a white coat told them to. Two thirds of them it turned out (well, a bit under half if you discount the ones who claimed afterwards that they only went along with it because it was a psychology experiment in a prestigious university, pretty clearly no one was actually being dangerously electrocuted). Videos show some subjects were completely torn up about inflicting pain, but in the end they still did what the forceful man with the clipboard told them. Bregman is quite candid that his aim is to do a hatchet job on Milgram's experiment, in order to protect his thesis of humanity's innate goodness (just as it was for all the other things he's discredited - set your biasometers accordingly). Bregman spends a section trying to pick holes in the experiment, without much success. He then admits that he's not had any success, and that Milgram's experiment replicates. Where does all of this leave us? My conclusions are: It's possible to get ordinary people to do terrible things, but it's not that easy. Left to their own devices they don't spontaneously turn sadistic.

Don't trust any study which hasn't been replicated Why you shouldn't stand by the bystander effect In 1964 at 3:19am Catherine Genovese was attacked in front of 38 witnesses in a nice neighbourhood in New York. For half an hour none of them did anything to help, allowing her attacker to strike again. Finally at 3:50am one calls it in. The police arrive two minutes later, but it's too late for Kitty. This phenomenon is called the bystander effect. In an experiment where subjects hear someone in trouble they rush to help, but if they know 5 other subjects are also listening in only 62% of them do - it's someone else's problem. If Kitty had awakened only one person she might still be alive. Except that once again I've told you how Kitty Genovse's murder was reported, not what actually happened. Let's try again. At 3:19am Kitty's scream rings out. There aren't 38 people who hear it - it's cold, they have their windows shut, and they're asleep. 38 is the number of people the police interviewed afterwards, most of whom did not witness anything. Of those who do wake up and look out they see a woman lurching down the street, apparently drunk. Nonetheless two of them immediately call the police, who have other drunk people to deal with, and decide this isn't very important. Two people witnessed the actual attack. One did indeed do nothing. The other was scared of being picked up by the police for being drunk and homosexual in a built-up area (this was 1964), so he told a neighbour, who immediately rushed down to Kitty, heedless of the danger. Five days later Kitty's murderer was caught after a bystander noticed a man carrying a TV set out of a neighbour's house. He and a friend called the police, and disabled the man's car. And the bystander effect itself? It's real, and it replicates, for the sort of low jeopardy situations you can get an ethics committee to sign off on, but what about violent situations like Kitty's? They were unstudiable until Marie Lindegaard had the bright idea of using CCTV footage of real incidents to evaluate bystander behaviour in violent situations. In these high stakes situations bystanders intervene 9 times out of 10, with the rate of intervention rising if there are more bystanders. In the studies bystanders were prevented from interacting, but in real life where they can communicate bystanders exhibit spontaneous team work. I guess I need to add 'don't trust the New York Times' to my list of lessons learned (apparently they sometimes threaten to do other bad stuff as well). Part 3: Against Empathy, God and Civilisation Empathy is too narrow The German infantry of WWII was perhaps the most impressive in history. Martin Van Creveld has calculated that the average German solider inflicted 50% more causalities than his allied counterpart. The Italians in Africa hated them, yet admitted they would have been crushed by the British if not for them. When the Soviets were rolling up their eastern frontier, and allied armies had successfully landed across France it was pretty clear that Germany was toast, but they fought on with astonishing tenacity, and a shockingly low desertion rate. Trying to figure out how to break the German morale, allied psychologists interviewed German POWs. Were they motivated by patriotism? A belief in Nazism? A mistaken belief that this war could still be won? An indoctrinated hatred of Jews? No, the secret was friendship. The Germans had a tremendous 'marital ethos', placing a high value on loyalty, camaraderie and self-sacrifice. Ideology was present, but entirely secondary. Bregman speculates that the German army was better because the friendships of its soldiers were stronger, but admits this is only speculation: interviews of British and American soldiers produced the same results. His key point is that empathy - such as feeling for your fellow soldier - can be a force for evil rather than good, because we can't be empathetic for all humans, only for ones we 'see'. He quotes Professor Paul Bloom who has written a book. "It's about empathy," he says. "I'm against it." (The book is subtly titled Against Empathy). Experiments on babies and toddlers show that they are generally eager to help, but easily manipulated. There's an experiment that shows babies two puppets, one being helpful and the other being mean. After the show all the babies want the helpful one, but show the mean puppet sharing their preference between crackers and green beans, and suddenly they'll take that one over one that was helpful but different from them. Adults are not beyond a bit of empathy manipulation either. People were told the sad story of Sheri Summers, a 10 year in need of a transplant. Would they bump her up the list, ahead of other people whom they knew nothing about, but the doctors who ordered the list believed were better candidates? No, on the whole they wouldn't. Then they took another group given the same scenario, but with the additional instruction to imagine how she felt. Suddenly the majority were up for throwing justice and rationality to the wind (it'd be nice to check whether the effect moved from just below half to just above, but the paper is behind a paywall). Power kills empathy 500 years ago Machiavelli literally wrote the book on how to use immoral means to maintain power. Today this approach is called 'realism', reflecting the confusion between real and cynical with which Humankind began. The Prince has maintained its fame ever since, but being old and famous are no guarantees of being correct, see for example Aristotle on physics, race or women (but don't fall into the trap of thinking Aristotle was wrong about everything - that man was prolific). When Professor Dacher Kelter started working on the psychology of power in the 90s he noticed two things: Everyone assumed Machiavelli was right

Inline links: 9 times out of 10, other bad stuff, paper

Highlights From The Comments On Missing School

August 26, 2021 · Original source

It would be hard to openly have social services for poor children. Partly this is because Americans don’t like paying for anything that’s too openly a social service aimed at the poor, which means a lot of social service work gets picked up by other systems in roundabout inefficient ways.

I really don’t view MR or links as a chance to dunk on people, but this is so, so wrong, and so indicative of the problems with public health “experts.” More here. That is an example, and in my view an instructive one, but really not interested in making this about any particular person. It was in turn taught by someone else, and it is believed by many in the field. The actual reality is that even very poorly educated Americans, on the whole, hold more sensible views than that.

Inline links: this is so, so wrong, here

Highlights From The Comments On Health Care Systems

January 27, 2022 · Original source

United States (GDP $21T): 2007: $131B 2012: $119B 2013:$143B, 2014: $154B, 2015: $163B, 2016: $173B,2017: $182B, 2018: $194B

So we have a drug industry that basically works by researching drugs to sell them in the United States; but then also pushing the drugs through the relatively easier regulatory regimes in the rest of the world to also sell the drugs everywhere else possible where the only investment that those additional sells need to justify recouping is the cost of getting the approvals since all of the research is already done.

And we end up with a system where drug development is worthwhile if and only if those drugs end up being sold in the United States, and where the FDA has the most stringent approval process, and nobody really has an incentive to change this. American regulators and politicians get disproportionately more power out of this arrangement. Drug companies make their profits. American insurers are able to pass along and distribute the costs across the population so they make their profits too. European countries get their drugs relatively inexpensively, and are existing in a legal context where that is their only real incentives since they really can't increase their ability to regulate drugs because the power that exists there is distributed throughout the EU rather than possessed by the governments of the member states. And the members of the EC probably are a bit unhappy and trying to increase their own ability to regulate things, but they're sufficiently disconnected from the powers of the member states that what they want doesn't really matter. (So Europe has somehow found a way to make the people who have the most incentive to increase the price of drug R&D there from having their voices heard.)

Ukraine Warcasting

March 01, 2022 · Original source

He argues that the West is overestimating Ukraine - Russia is closer to Kyiv than America was to Baghdad at this stage of their Iraq invasion, and everyone was impressed with that stage of the American campaign. But he was intellectually honest enough to give a very specific prediction - collapse of Ukrainian resistance within a week - so he can’t really get out of admitting he miscalculated here. I definitely think both these things can be true at once: the Russians underestimated the extent of Ukrainian resistance even as the West may be overestimating it.

I’m proud of my record forecasting the invasion, given that it went against most of the predictions of those who generally share my foreign policy views. Anyone can occasionally be correct by following the same heuristic they always use, but I showed intellectual flexibility here by determining that American intelligence was likely correct. Karlin is the only other prominent US foreign policy skeptic I know of who thought war was even more likely than the conventional wisdom suggested, and he deserves credit for that (if you know of others, mention them in the comments). Part of the reason I came to the right conclusion was that I was even more pessimistic than most anti-interventionists were about the degree of rationality present in American foreign policy. For example, my friend Max Abrahms was saying until very recently that Putin was hoping for some concessions that would allow him to avoid war (to be fair, Max has been more correct than me on the invasion running into difficulties). I thought that was possible too, but I had little hope that American politics would allow Biden to strike a deal. When it became clear that negotiating over the NATO open door policy wasn’t even on the table, I increased my estimate of the probability for war. To his credit, Max has admitted I was right, as have others I’ve been texting with over the last few months. I also give credit to Saagar, Philippe, and Michael Tracey for publicly acknowledging mistakes.

Inline links: would allow him to avoid war, as have others, Saagar, Philippe, Michael Tracey

Once we step aside from culture war resentments and focus on the hard realities of geopolitics, it is clear that Russia will eventually get its way because it cares more about Ukraine than the US does, and has the ability to threaten or use military force to get what it wants. When resolve and capabilities line up on the same side, that side is going to win. And the reason that Americans don’t care about Ukraine is that Ukraine objectively does not matter to the US. All the sophistry in the world coming from MSNBC hosts, ex-generals on the payrolls of defense contractors, and think tank analysts can’t change people’s perceptions here.

Response To Alexandros Contra Me On Ivermectin

February 01, 2023 · Original source

But there were three new big RCTs - I-TECH from Malaysia, and ACTIV-6 and COVID-OUT from the United States. All three found no effect. With these studies (notably from low-parasite areas) meta-analyses of mortality no longer show any effect.

Inline links: no longer show any effect

The control groups in high-worm-prevalence-area studies had no more deaths than in low-worm-prevalence-area studies. If the worms were killing people in the control groups (who ivermectin was then saving in the treatment groups) you would expect more deaths. You can find arguments for all these points at the link. (One additional thing Alexandros does that I really like: he compares the Strongyloides hypothesis - as an attempt to explain why these studies keep getting such different results - to other hypotheses. For example, studies in Latin America get negative results more often than others. This really feels like confronting the real question. He finds that Latin American studies do find lower efficacy for ivermectin than the other mostly Asian studies, and hypothesizes that this is because ivermectin is very popular in Latin America, the “control” group illicitly takes it without telling the researchers, and so these studies are inadvertantly comparing two ivermectin groups. This is another clever and elegant theory. Unfortunately, the recent spate of negative American studies sink it6. Still, I agree there is a strong geographic element here; worms are one possible explanation, but there are others - including the scientific culture in different countries. I appreciate Alexandros highlighting how much this is true.) I asked Dr. Bitterman for his thoughts. He reiterates that although steroids are one major cause of Strongyloides hyperinfection, another is eosinopenia, a decrease in the immune cells that fight parasites. COVID can cause eosinopenia directly, so just because a COVID patient didn’t get steroids, or was only on steroids for a short period, doesn’t prove that the patient couldn’t have had hyperinfection. On the mixing of different sources to get Strongyloides prevalence data, he said: As mentioned in the paper, when available we attempted to granulate by regional prevalence. This was often not possible because robust data did not available for a given country. Brazil is a large country (and multiple different studies in our analysis were in Brazil) with variability and Paula was a robust study. We decided to attempt to granulate instead of stacking the Brazil countries with the same prevalence even though they are in very different regions. His re-analysis is a crude one, and he often switches between using that analysis and the ecological model study. At the time of out paper's publication, the ecological model was not available. I offered to re-do the whole analysis with that study's raw data with a mutually agreed upon methodology, which we have not fully ironed down yet. On the long delay before hyperinfection kills: I don't think it happens in 1 or 2 weeks. But 3-4 weeks (within almost all study durations) is certainly not unheard of (again, without being treated). Even 1/3rd of the [untreated animals in a marmoset study Alexandros cites] died within the range of the study durations." On the more general argument: I have a higher credence of the effect modifier than he does. Perhaps the main thing I don't think he fully appreciates is just how few deaths need to be explained by this in order to substantially shift the RR. Even if this is the case for just a handful of control group deaths, the RR change is not trivial simply because of how low events the entire supposed benefit was in the first place. Furthermore, the new trials (ACTIV-6 400, ACTIV-6 600, COVID-OUT), while they all have very low mortality rates, all tip the needle in favor of the hypothesis. As expected, in the USA where the prevalence is near 0, all the deaths of those trials were in the ivermectin group (again, small event rates though). I could re-do the analysis with the new data even with his critiques of how he thinks it should be done (which is highly debatable) but I didn't end up doing it because at this point it would be an historical debate since the world has moved on from the topic. There are other points of course, there's quibbles line by line. I find Alexandros’ adjustment for Brazil somewhat convincing - not necessarily as a good adjustment, just in the sense that some adjustment needed to be done. I think the broader point is that results on the border of “statistical significance” often appear or go away depending on ambiguous decisions about coding single cases. Alexandros realizes this and includes a more gestalt style chart directly showing the correlation, which he says goes below the significance threshold when you recode the Brazilian studies. This chart seems to be missing some studies which might change its conclusions; it was made by a third party and Alexandros is going to get back to me with more information. Dr. Bitterman adds that more recent American studies strengthen his hypothesis. More discussion with Dr. Bitterman has also helped me better understand the context of this theory. Ivermectin does worst in studies of intermediate clinical endpoints: hospitalization, ICU admission, recovery time. It does best in studies of viral clearance rate and mortality. Viral clearance rate is a weak preclinical endpoint: not only is it especially susceptible to biases and file drawer effects, but it’s not that interesting unless it affects later clinical outcomes; many drugs change secondary endpoints but fail to change the things we care. Mortality is (usually) a strong and important endpoint; apparent positive results of ivermectin here require an explanation. The Strongyloides hypothesis tries to provide it. But I erred on my earlier post by holding it up as “the” explanation for a large and heterogenous group of studies which were mostly looking at endpoints other than mortality, or as a counter to ivmmeta’s analysis which found positive results everywhere for everything through statistical incompetence. I think I implicitly believed a stronger version of the worm hypothesis - that even in places without literal Strongyloides literally killing you, some people had some parasitic worms that were holding them back, ivermectin killed those worms, and that made them healthier overall and better able to deal with COVID. But nobody has asserted or defended that hypothesis and there’s no evidence for it. When I asked Dr. Bitterman, he pointed out that the opposite was at least as credible: parasitic worms depress the immune system, but immune overreaction is a major cause of death in COVID, so getting rid of them could make things worse rather than better. The original post should have explained this hypothesis better, devoted less emphasis to it, and focused more on publication bias and other issues that could explain the overall result. In some cases, these issues would have shed more light on the mortality statistics too. On my original post, I wrote: Parasitic worms are a significant confounder in some ivermectin studies, such that they made them get a positive result even when honest and methodologically sound: 50% confidence In retrospect this is framed too weakly - “significant” in “some” studies is compatible with irrelevant overall. Still, sticking to the spirit of what I meant, I think I would lower this guess to more like 35% now , and lower my overall estimate of how much of the mystery it explains even further. I’m not an expert on this, you shouldn’t care about my exact probability, and I’m only mentioning it to communicate clearly and try to hold myself accountable. V. Publication Bias Alexandros has various arguments against funnel plots in general, and Dr. Bitterman’s funnel plot in particular. Some of these arguments are reasonable, but taken together they would discredit 95 - 100% of all funnel plots everywhere. Trying to destroy the whole institution of funnel plots just because one of them disagrees with your hypothesis is . . . honestly a move I have to respect. I agree that these provide Bayesian evidence, rather than 100% irrefutable evidence, of publication bias, and need to be considered in the context of everything else going on. After doing that, I still think they’re publication bias. That makes publication bias more important. In the original post, I included this funnel plot from Dr. Bitterman: In case you haven’t seen one of these before: this plots how big an effect the study found (horizontal axis) against study size (vertical axis). Studies that find ivermectin had no effect are at the center (RR = 1), studies that find a strong curative effect are to the left, studies that find a strong harmful effect are to the right. When all studies are good, we have no reason to expect a correlation between study size and ivermectin efficacy - any deviations from the true effect should be random. This would look like a triangle centered around the true effect of the drug, with an equal number of studies on both sides. When there is a lot of publication bias, we should expect that small studies get published only if they find exciting results, and big studies get published regardless (because a lot of work went into them, someone will want to publish them, and journals will accept them regardless of how exciting they are). So here you would expect to see big studies around zero, and an asymmetric tail of smaller studies heading in the more-exciting direction. This is what we see on Dr. Bitterman’s plot, suggesting strong publication bias for ivermectin results. Alexandros’ full counterargument is here. Trying to sum it up: Funnel plots can sometimes look deceptive, or be misreported, and are generally suspect.

Inline links: 6, studies of intermediate clinical endpoints, https://substackcdn.com/image/fetch/$s_!rlgm!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F174e569d-8a2c-4c11-a2ff-d355f4bce5b1_1200x808.jpeg, here

Alexandros writes: “Given that these new trials were mostly in late '21 and '22, and the mortality in them was extremely low, I don't believe they would alter the results of my analysis, since studies with few if any events get very low weights in this style meta-analysis. I haven't re-run it, but if it will make a difference, let me know and I'll give it a go. I also think (but won't take it the wrong way if you ignore me on this) it is unfair to introduce new data mid-argument. As you probably know, I have serious objections about these negative American studies (the most serious of which I have not yet published) and believe they are worthy of a separate conversation. My point, i believe, has consistently been that the confidence people are projecting that ivm doesn't work isn't supported by the evidence. either strongyloides was particularly strong as an explanation at the time, or there were other hypotheses we should have considered.”

The Question Of Separatism

May 19, 2023 · Original source

This book is Jacobs’s least read. It was published in 1980, right after the first referendum where Quebecers voted to remain a part of Canada. It is based on lectures that Jacobs (who was an American but had moved to Canada in 1968) gave in Toronto right before the referendum. It’s not hard to guess why the book didn’t have a huge (read: any) impact. First, most people outside Quebec or Canada don’t have any reason to care. Second, the essay — which was written in English — argues in favor of the secession of Quebec, which virtually no one among the English-speaking population of Canada agreed with. The natural reaction from Canada’s intelligentsia was to ignore the book altogether. Meanwhile, few people in Quebec itself read it, since the referendum was over; it wasn’t even translated into French until decades later. As a result, The Question of Separatism sits awkwardly in Jane Jacobs’s bibliography, as if it were “a mistake in an otherwise brilliant career,” like I read somewhere. In a 2005 interview, one year before her death, Jacobs said that no journalist ever asked her about it. But the book was not a mistake. I don’t claim any special insight here: Jane Jacobs herself said so in that same interview. She said that she would have written the same book in 2005, “because that’s the way it is in the world, and it still holds.” Besides, The Question of Separatism is in fact not that much about the specifics of Quebec’s political situation, but rather about interesting generalities: what size means for countries and organizations, and why the fate of nations depends primarily on what happens in their cities. Taken together with Cities and the Wealth of Nations, which Jacobs wrote a few years later to expand on those ideas, we get a coherent and deeply interesting philosophy of economics: one that favors the local scale, cities and small countries, antifragility long before Nassim Taleb coined the term, and avoiding grandstanding theories that always fail to take into account the real complexity of the world. I. A Fake Mystery Cities and the Wealth of Nations opens on an economic mystery. “For a little while in the middle of this century,” writes Jacobs, “it seemed that the wild, intractable, dismal science of economics had yielded up something we all want: instructions for getting or keeping prosperity.” This was the 1940s to 1960s, and economists thought they had it all figured out. It was the golden age of high modernism and scientific technocracy. Everywhere from China to the Soviet Union to the United States and Britain and the nascent European Economic Community, leaders were coming up with elaborate plans, rooted in macroeconomic theories, that were supposed to guarantee future wealth and avoid economic crises. The theories had been developed by many thinkers over the previous two hundred years: Richard Cantillon, Adam Smith, John Stuart Mill, Karl Marx, John Maynard Keynes. Jacobs explains how they each had their own ideas of how the economy worked, disagreeing over things like whether supply or demand was the main driving mechanism, but they all agreed on a fundamental fact: inflation and unemployment have an inverse relationship to each other, like a seesaw. High inflation comes with low unemployment; high unemployment comes with low inflation, or even deflation when prices drop. The Great Depression, a time of deflation, had provided proof of the seesaw. Big government projects, as prescribed by Keynesians, were a way for states to reduce unemployment and bring the seesaw back in a balanced state. Economists developed fancy models, based on historical data, to predict the behavior of the economy. The Phillips curve in particular became popular. It was the golden age of technocracy; it was the triumph of high modernism. From now on wealth was assured, because we weren’t blind anymore: we had the curves. And yet — by the 1970s and 1980s, when Jane Jacobs was writing, the theories all stopped working. There was high inflation and high unemployment. People called it stagflation. Keynesian advisers in various governments were devastated: either their ideas were wrong, or they were applying them wrong. Economists such as Milton Friedman, from a rival school of economists called the monetarists or the Chicago school, came to the rescue — but their remedy, Jacobs believes, only made things worse. Whatever governments did to increase employment made inflation worse; whatever they did to attenuate inflation killed employment. The seesaw from the theories was working in application, even though it didn’t explain reality anymore. Stagflation was not supposed to exist, so stagflation could not be fought. At this point we’re near the end of Chapter 1, the densest part of the book. Jacobs has artfully guided us along economic history and laid out the mystery for us. What’s going on? we wonder. How are we supposed to deal with the two-headed monster of stagflation, if all economists are stumped? Then Jacobs, in a masterstroke, flips the whole thing over. I was impressed enough that I would have inserted a spoiler alert here, if it didn’t feel so silly putting a spoiler alert in an essay on economics. Stagflation is not a strange monster from legend. It is, Jacobs says, just the normal state of everything. Backward economies are in fact constantly in a state of stagflation. The prices in a poor country like Portugal or India (her two examples) feel low for an American or Canadian, but they’re high for most Portuguese or Indian people. At the same time, Portugal and India provide too few jobs to their residents. Inflation and unemployment are both perennially high, and none of that feels surprising whatsoever. Stagflation, in short, is just good ol’ poverty. All these fancy economists, from Cantillon in 1700s France to Keynes and Friedman in the 20th century Anglosphere, were thinking and writing about unusual places: rich countries that were undergoing fast economic development. They were making the classic mistake of treating poverty as a mystery and wealth as a given, when in fact poverty is the normal order of things and wealth, when it does occur, is what warrants an explanation. The result is that we don’t really know how to fix the economy of poor countries, nor do we know how to deal with decline in rich countries, whether we call it stagflation or something else. Jacobs derives from this a pretty damning view of macroeconomics. It is to her a science that has failed again and again, each time engulfing the equivalent of billions of dollars in wasted wealth. “We must,” she writes at the close of Chapter 1, “find more realistic and fruitful lines of observation and thought than we have tried to use so far. It is bootless to choose among existing schools of thought. We are on our own.” Fortunately, she has some ideas. II. Nations and the Wealth of Cities The original sin of macroeconomics, Jacobs believe, is to treat sovereign countries, or nations, as the main unit of economic analysis. This error, she claims, goes back to mercantilism, one of the first formal economic policies. Oversimplified, mercantilism states that wealth is synonymous with the amount of gold and silver in a nation’s treasury. This makes nations the main unit of economic analysis by definition. It’s a tautology — and one that was somehow embedded so deep in economic thinking that even the non-mercantilist Adam Smith would eventually choose, for his masterpiece of economic theory, the title An Inquiry into the Nature and Causes of the Wealth of Nations. Today, even though mercantilism has long been obsolete, we perpetuate the same tautology whenever we talk of the Gross Domestic Product or look at the very nice charts from Our World in Data, which for the most part allow only one level of resolution: sovereign countries. Of course, nations are an economically important concept because of that one property: they are sovereign, and therefore they write laws and implement policies that affect the economy. These policies can be productively compared. But that’s about it — for everything else, nations aren’t the right way to think about wealth. One reason is simply that they’re very different from one another: “it affronts common sense,” Jacobs writes, “to think of units as disparate as, say, Singapore and the United States, or Ecuador and the Soviet Union, or the Netherlands and Canada, as economic common denominators.” I would add that countries are arbitrary and changing: when the Soviet Union was replaced by 15 sovereign countries, the economic reality didn’t suddenly reshape itself to match the new borders. Lastly, nations contain, under the hood, many sub-economies that are also highly different from one another. None of that is secret or forbidden knowledge. Everyone has always been aware that New York City, or Milan, are economically very different from rural Mississippi or Sicily. But I find that it’s far easier to think in terms of “the United States” or “Italy,” especially when you’re not from there. Nations are an abstraction of real-life complexity, and are accordingly very tempting to use. Also, they’re often the entities that collect statistics, which is another difficult-to-resist temptation for anyone who likes quantitative data. Cities as Radiators of Economic Forces If nations aren’t the best unit to analyze the economy, what is? This is a Jane Jacobs book, so the answer is obviously going to be cities. Jacobs doesn’t actually give a clear argument why. Maybe that was in her previous book, The Economy of Cities. So far as I can see, her reasoning is, ironically, a bit tautological: “all developing economic life depends on city economies; it depends on them by definition because, wherever economic life is developing, the very process itself creates cities and has probably always done so.” But so far as I can see, this reasoning is correct. Cities concentrate people, and therefore economic life, and therefore economic power. The driving force for all this is a phenomenon that, from what I gather, was discovered by Jacobs when she wrote The Economy of Cities: import replacement. Consider, say, Boston back when it was a tiny settlement, not yet a city, in colonial times. At first, Boston didn’t produce much, especially not much that would be of interest to its main trading partner, London. It exported some natural resources: timber, fish. Whatever else the Bostonians needed, they needed to import it from other cities, again mostly London. (Remember to think of imports and exports in terms of cities, not nations.) For instance, at first, all metal tools in Boston came from European cities, and were paid for by the revenue from selling the timber and fish. Then, one day, some Bostonians decided to build an ironworks and make metal tools themselves. (Pictured: a reconstruction of the Saugus Iron Works, established 1646.) This wasn’t of any interest to London or other European cities. The Bostonians weren’t nearly as good or efficient at making metal tools as Londonians were. So Boston couldn’t export the metal tools back to Europe — but it could use them internally, and also export them to other American cities that were about as poor as Boston was, or poorer. Internally, this meant the spark of a manufacturing economy in Boston, as easily obtained metal parts made it easier for other Bostonians to replace other imports from European cities, and eventually develop a symbiotic network of industries. It also meant that the revenue from fish and timber could be used to import new things, including new innovations from European cities (which would later become opportunities for more import replacement). And because there were customers for Boston-made metal goods in New York and Philadelphia, and eventually Cincinnati and Chicago and Pittsburgh as these cities came into existence, it meant additional revenue for Boston that it could reinvest into developing its production further. For Jacobs, virtually all city development can be seen through the lens of import replacement (which, to be clear, has approximately nothing to do with policies of import substitution industrialization; import replacement is not a policy, but a naturally arising free market phenomenon). Her book contains many other examples than Boston, such as Venice, which started off in the early Middle Ages as a small town that sold salt to Constantinople, but then diversified its production to become one of the wealthiest cities of its time; or Taipei and Kaohsiung, two cities in Taiwan that kickstarted their development not long before the 1980s, by forcing expropriated landlords to invest into local import-replacing businesses. One is reminded of Scott’s review of How Asia Works. Import replacement, then, is what makes cities economically powerful. And this power is so great that it causes ripples in distant places. In fact it is the main reason that anything happens at all in non-city areas. Jacobs gives the example of Bardou, a small village in southern France. Bardou looks like this: To the extent that Bardou ever had an economic life, that life was almost entirely driven by distant cities. In ancient times, the area was populated because of iron mines nearby. The mines were exploited to serve the needs of people in the distant cities of Lugdunum (Lyon), Nemausus (Nîmes), or even Rome. As Jacobs notes, we could say that the mines served “the Roman Empire,” but that would be another example of using the abstraction of sovereign countries when we should instead be specific. It was Lugdunum, Nemausus and Rome that wanted the iron — not some random rural area of the empire, and certainly not the part of the empire in which Bardou was located. Eventually the mines and the region were abandoned. More than 1,000 years later, peasants moved into the area and built the modern village. For centuries they lived a wretchedly poor life of subsistence farming. No cities exerted any influence on it, and indeed nothing happened. Then, in the 19th century, the people of Bardou learned that they could improve their situation by moving to distant cities such as Paris, and most of them did. Again, the force wasn’t being exerted by “France”; Bardou was already part of France. The force was specifically being exerted by Paris and other cities with jobs for poor peasants. By the 1960s, only one old man was left. That’s when two foreign visitors, a German and an American, happened upon the village, decided to buy most of it, revitalized it, and turned it into a tourist spot (and even, for a brief time, into a set for a movie company). Today Bardou is a popular place for travelers — who are mostly city people, and spend money that was mostly earned in cities. The Bardou story contains examples of several of the forces that import-replacing cities radiate, according to Jacobs. These forces are central to her thinking. There are five of them: Markets. Cities house a lot of people who need a lot of goods and services, and are therefore strong markets to sell goods and services to. This was the force that acted on the Bardou area when it was a Roman mining region, and again today when it functions as a tourist spot for city vacationers.

Inline links: Phillips curve, https://substackcdn.com/image/fetch/$s_!9wEn!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F850ce64a-4367-4a7a-a9ec-e8eb1af3ed08_399x292.png, Our World in Data, https://substackcdn.com/image/fetch/$s_!zS15!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F7d533e64-f407-4b05-aea5-5b5a9dbdc7bc_1600x1130.png, import replacement, https://substackcdn.com/image/fetch/$s_!5j2T!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F7f2675d9-ce56-4ac5-9b78-a16720269dea_1600x1159.png, import substitution industrialization, Scott’s review of, Bardou, https://substackcdn.com/image/fetch/$s_!RfMs!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fc119b085-f7b3-4e09-a586-9f4fc4c2ea21_1200x1600.png

Of course, nations are an economically important concept because of that one property: they are sovereign, and therefore they write laws and implement policies that affect the economy. These policies can be productively compared. But that’s about it — for everything else, nations aren’t the right way to think about wealth. One reason is simply that they’re very different from one another: “it affronts common sense,” Jacobs writes, “to think of units as disparate as, say, Singapore and the United States, or Ecuador and the Soviet Union, or the Netherlands and Canada, as economic common denominators.” I would add that countries are arbitrary and changing: when the Soviet Union was replaced by 15 sovereign countries, the economic reality didn’t suddenly reshape itself to match the new borders. Lastly, nations contain, under the hood, many sub-economies that are also highly different from one another. None of that is secret or forbidden knowledge. Everyone has always been aware that New York City, or Milan, are economically very different from rural Mississippi or Sicily. But I find that it’s far easier to think in terms of “the United States” or “Italy,” especially when you’re not from there. Nations are an abstraction of real-life complexity, and are accordingly very tempting to use. Also, they’re often the entities that collect statistics, which is another difficult-to-resist temptation for anyone who likes quantitative data. Cities as Radiators of Economic Forces If nations aren’t the best unit to analyze the economy, what is? This is a Jane Jacobs book, so the answer is obviously going to be cities. Jacobs doesn’t actually give a clear argument why. Maybe that was in her previous book, The Economy of Cities. So far as I can see, her reasoning is, ironically, a bit tautological: “all developing economic life depends on city economies; it depends on them by definition because, wherever economic life is developing, the very process itself creates cities and has probably always done so.” But so far as I can see, this reasoning is correct. Cities concentrate people, and therefore economic life, and therefore economic power. The driving force for all this is a phenomenon that, from what I gather, was discovered by Jacobs when she wrote The Economy of Cities: import replacement. Consider, say, Boston back when it was a tiny settlement, not yet a city, in colonial times. At first, Boston didn’t produce much, especially not much that would be of interest to its main trading partner, London. It exported some natural resources: timber, fish. Whatever else the Bostonians needed, they needed to import it from other cities, again mostly London. (Remember to think of imports and exports in terms of cities, not nations.) For instance, at first, all metal tools in Boston came from European cities, and were paid for by the revenue from selling the timber and fish. Then, one day, some Bostonians decided to build an ironworks and make metal tools themselves. (Pictured: a reconstruction of the Saugus Iron Works, established 1646.) This wasn’t of any interest to London or other European cities. The Bostonians weren’t nearly as good or efficient at making metal tools as Londonians were. So Boston couldn’t export the metal tools back to Europe — but it could use them internally, and also export them to other American cities that were about as poor as Boston was, or poorer. Internally, this meant the spark of a manufacturing economy in Boston, as easily obtained metal parts made it easier for other Bostonians to replace other imports from European cities, and eventually develop a symbiotic network of industries. It also meant that the revenue from fish and timber could be used to import new things, including new innovations from European cities (which would later become opportunities for more import replacement). And because there were customers for Boston-made metal goods in New York and Philadelphia, and eventually Cincinnati and Chicago and Pittsburgh as these cities came into existence, it meant additional revenue for Boston that it could reinvest into developing its production further. For Jacobs, virtually all city development can be seen through the lens of import replacement (which, to be clear, has approximately nothing to do with policies of import substitution industrialization; import replacement is not a policy, but a naturally arising free market phenomenon). Her book contains many other examples than Boston, such as Venice, which started off in the early Middle Ages as a small town that sold salt to Constantinople, but then diversified its production to become one of the wealthiest cities of its time; or Taipei and Kaohsiung, two cities in Taiwan that kickstarted their development not long before the 1980s, by forcing expropriated landlords to invest into local import-replacing businesses. One is reminded of Scott’s review of How Asia Works. Import replacement, then, is what makes cities economically powerful. And this power is so great that it causes ripples in distant places. In fact it is the main reason that anything happens at all in non-city areas. Jacobs gives the example of Bardou, a small village in southern France. Bardou looks like this: To the extent that Bardou ever had an economic life, that life was almost entirely driven by distant cities. In ancient times, the area was populated because of iron mines nearby. The mines were exploited to serve the needs of people in the distant cities of Lugdunum (Lyon), Nemausus (Nîmes), or even Rome. As Jacobs notes, we could say that the mines served “the Roman Empire,” but that would be another example of using the abstraction of sovereign countries when we should instead be specific. It was Lugdunum, Nemausus and Rome that wanted the iron — not some random rural area of the empire, and certainly not the part of the empire in which Bardou was located. Eventually the mines and the region were abandoned. More than 1,000 years later, peasants moved into the area and built the modern village. For centuries they lived a wretchedly poor life of subsistence farming. No cities exerted any influence on it, and indeed nothing happened. Then, in the 19th century, the people of Bardou learned that they could improve their situation by moving to distant cities such as Paris, and most of them did. Again, the force wasn’t being exerted by “France”; Bardou was already part of France. The force was specifically being exerted by Paris and other cities with jobs for poor peasants. By the 1960s, only one old man was left. That’s when two foreign visitors, a German and an American, happened upon the village, decided to buy most of it, revitalized it, and turned it into a tourist spot (and even, for a brief time, into a set for a movie company). Today Bardou is a popular place for travelers — who are mostly city people, and spend money that was mostly earned in cities. The Bardou story contains examples of several of the forces that import-replacing cities radiate, according to Jacobs. These forces are central to her thinking. There are five of them: Markets. Cities house a lot of people who need a lot of goods and services, and are therefore strong markets to sell goods and services to. This was the force that acted on the Bardou area when it was a Roman mining region, and again today when it functions as a tourist spot for city vacationers.

Inline links: import replacement, https://substackcdn.com/image/fetch/$s_!5j2T!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F7f2675d9-ce56-4ac5-9b78-a16720269dea_1600x1159.png, import substitution industrialization, Scott’s review of, Bardou, https://substackcdn.com/image/fetch/$s_!RfMs!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fc119b085-f7b3-4e09-a586-9f4fc4c2ea21_1200x1600.png

An oversized transplant force creates a transplant economy: a place that depends on industries that it did not generate itself. Getting a transplanted factory is always tempting for the governments of poor regions. But while the new jobs do alleviate poverty, transplants almost never lead to durable economic development (with rare exceptions, such as Taiwan). Jacobs has multiple examples, but the one I like most is Iran just before the revolution, when the Shah used oil money to buy a helicopter factory from the United States — thereby spurring a lot of development in the United States, where many companies got involved in building the factory, and almost none in Iran.

Your Book Review: The Laws of Trading

July 21, 2023 · Original source

“Residential real estate has historically returned significantly below equity markets over long time horizons” But I’m not so sure that these lessons are directly applicable to other areas of life. Some of the best things in life come from lashing yourself to the mast, burning the boats behind you, willingly giving up liquidity. The deepest monogamous relationships are built from an irrational investment in one other person, saying “In sickness and in health, until death do us part.” How many scientific problems were solved because one person had an irrational willingness to: Just. Keep. Going. Sometimes it’s powerful to use the sunk cost fallacy to your advantage. Investing in relationships, subject matter expertise, even putting down roots via *gulp* homeownership reduces your liquidity, but also leads to some of the best (if intangible) things in life. 5: Edge If you can’t explain your edge in five minutes, you don’t have a very good one. OR The long-term profitability of an edge is inversely proportional to how long it takes to explain it. The Efficient Market Hypothesis is one of the core concepts taught in Finance 101. The Efficient Market Hypothesis is a lie. The person that better understands the nature of a small sliver of the world (e.g. Apple’s share price) will make more money than others. Modern financial markets are exceedingly competitive. This means that the bigger you think your edge is, the more likely it is that you’re wrong. “Evolutionary thinking applies quite directly when thinking about the evolution of markets. Having an edge in a mature market means understanding the world better than other traders, even ones who are already highly skilled. In fact, the marginal trader in modern financial markets is quite sophisticated and skilled indeed.” Lebron here warns us of getting too cute with data, of changing variables. Enough randomness will produce an “edge” that is likely to break down the second a trading strategy hits the real world. You can always find a statistical correlation if you change enough variables. But this is fundamentally the same problem facing the replication crisis in social sciences. Lebron argues that we need stories here. Edge is expressed in stories: an edge does not exist without a clear mental representation of that edge. Pure linear algebra does not suffice. I’m not so sure. It seems like AI companies are pushing forward technology in a way that suggests that mental representations are not the only path to intelligence. Lebron discounts “black box” trading strategies without much discussion of their potential merits. Are all of RenTech’s models explainable by a story? The firm is notoriously secretive, so I don’t know, but I’d guess not. “Frequently a good trade appears, has a seemingly insurmountable difficulty, and it is mere persistence that knocks down the final barrier. There may have been many others who looked at the idea, wanted to do it, but couldn’t get past that last hurdle.” Before Sam Bankman-Fried was the face of Why Effective Altruism is Bad, before he even founded FTX, he made money arbitraging the difference between Bitcoin prices on Japanese and American exchanges. I’m reminded of that trade here. It isn’t a particularly elegant trade, it doesn’t require deep technical knowledge or any models. It was a schlep. It was all operational work: figuring out how to open a Japanese bank account, transferring money between the US and Japan, standing in line for hours every day at both US and Japanese banks (presumably this wasn’t the same person). In as technical a field as trading, sheer willpower is often what gets things done in the end. 6: Models The model expresses the edge. Lebron drills into us that a model is the tool for expressing an edge. The model is not the edge. The model does not give us unique knowledge about the world. The map is not the territory. He dives into the difference between generative (G) and phenomenological (P) models. G models express a worldview and fit data into that way of thinking, whereas P models solely look at the empirical data to build a worldview. Models of the world differ from models of markets, though. Markets have quick feedback loops, are explicit in terms of what they measure, and are easy to quantify at a specific point in time. Most of our models for the world, though, are ill-defined and explicit. Models are only as good as our assumptions. As an aside, this is a common criticism of rationality or Effective Altruism – you can justify any worldview if you assign your model input weights in just the right way5. I also tend to think that “traditional” EA is overly dependent on P models, and doesn’t embrace the G models that led to economic reforms in India in the 1990s or the economic policies that led to rapid economic development in Southeast Asia in the second half of the 20th Century. Interestingly, I think a lot of longtermist EA, specifically AI alignment, leans the other way, relying on G models which explicitly assume a certain P(doom) and work backwards from there. (Though I won’t pretend to be an expert here or to understand everything, so take this with a grain of salt.) Overall, startups and tech seem to take heed to Lebron’s lesson much better than the folks hanging out on this part of the internet: “Even if a model makes good predictions about some future value or event, that knowledge is useless without also knowing how to take advantage of that prediction.” Now we get a bit philosophical. By acting, you change the nature of the market. Your model predicts things that might not be true as soon as you start trading (and changing the environment) based on it. When you’re right, everyone else sees the same trades that your model does and will beat you to them. When your model is wrong, others don’t act, meaning adverse selection rears its ugly head once again. So your model shows you with an edge, but in practice you only make the trades where you don’t have an edge. Lebron closes by arguing that G models are best for understanding other people, and are good in and of themselves: “You can also see connections to traditional moral philosophy in thinking about modeling the behavior of others. To have a good G model about someone else is to have some measure of empathy and compassion for that person: what they’re like, what they think and feel, putting yourself in their shoes. Pragmatically, developing the skill of empathy and compassion for others is, aside from a moral good in itself, an excellent way to understand better the people who surround you. More people working to develop good G models of others is surely a small step to a better world.” 7: Costs and Capacity If you think your costs are negligible relative to your edge, you’re wrong about at least one of them. This section of the book displayed a good amount of epistemic humility, words that I didn’t expect to be typing in the context of a book about trading. Lebron tells us that trades don’t exist independently in the universe — in the n-dimensional space of all possible trades seeking to optimize profitability, if you have a gigantic mountain of profitability, someone else has probably at least discovered the base. So you probably don’t have a profitable trade; rather, you are misunderstanding something about your trade. You’ve either overestimated profitability or underestimated cost. Lebron highlights four types of trading costs: [graph that didn’t show up correctly here: two axes and four quadrants, with the axes being visible ←→ invisible costs and linear ←→ nonlinear costs] Here, we’ll focus on Quadrant 4, where he highlights a few interesting phenomena. Herding. It’s likely that if you have a profitable trading strategy, either: Other firms discovered a similar strategy independently and/or

Inline links: replication crisis, RenTech’s, arbitraging the difference between Bitcoin prices on Japanese and American exchanges, 5

Your Book Review: The Family That Couldn’t Sleep

July 12, 2024 · Original source

(This report was, as it happens, published in the exact same month as The Family That Couldn’t Sleep.) DTM came to know the family well. He befriended them by way of two members of their younger generation, Lisi – a woman terrified by the shadow of the disease, and Ignazio – the doctor she had married, who was more terrified by the shadow of the disease. Ignazio put together the pieces of the family puzzle, consolidating all the disparate diagnoses into a single disorder and filling out a lot of blank spots on family trees. When DTM came along, he was able to help Ignazio make the case that the family would benefit from the spotlight – that greater awareness of FFI could lead to a cure both for them and for a slew of other prion diseases. As it so happens, he is one of those nonfiction authors who serve as a character in their own story. DTM has some form of progressive muscular palsy. He is, or at least was in 2006, not entirely sure what it is. The relatively unimpressive state of genetics at the time had not identified his causative mutation, though it looked a lot like one of the rarer forms of Charcot-Marie-Tooth disease2. DTM is pragmatic about this, the way everyone chronically ill is either pragmatic or doomed. Whatever he has, it is a defect in protein structure; his peripheral nerves decay not because of a problem with the nerves themselves but an inability of their scaffolding to hold them together, as he puts it. The last chapter of the book dwells on this, on the web of connections popping up between a thousand disorders. DTM’s disease is something vaguely similar, if you squint, to an exceptionally slow-progressing motor neurone disease; if you jump another level out, you see amyloid plaque diseases like Huntington’s and Alzheimer’s, and if you jump yet another level out, you see something like prions. His interest in the Venetian family was driven by this. Some of its members thought this a beautiful act of sympathy; others thought him a grotesque parody of themselves, an onlooker, a gawker, peddling their tragedy to salve his relatively insignificant problems. They are, he thinks, both right. That’s the beginning, and that’s the end. What happens in the middle? --------------------------------------------------------- The Venetian family lends the book its title, but they’re really more of a framing device. The Family That Couldn’t Sleep is separated into four parts, of which the first and fourth – the shortest by far – deal with the family. Part 2 is kuru, the king of fucked up diseases you read about in clickbait Weird Medicine listicles. Let’s talk about kuru! Kuru, is, famously, the prion disease you get if you eat another person’s brain. Well, not quite. It’s a prion disease that became endemic amongst women in the Fore society, who ritually ate brains, one of which had an inherited or spontaneous prion disease. This is an important note – there’s a tendency (which the book’s later chapters engage in) to assume cannibalism just has a Prion Disease Generator attached. If you eat people who don’t have prion diseases, you won’t suddenly get one. Uh, don’t eat people. Anyway, part 2 is DTM’s historiography of Fore-Westerner first contact. It’s hilarious. Papua New Guinea is a frankly ridiculous place; one of the all-time best Lyttle Lytton winners (worst first sentence from a hypothetical or, in this case, real work) was “Papua New Guinea is so violent that more than 820 languages are spoken there”. The native residents were so hostile to outsiders that all the colonial empires had cut their losses – and when you think about the places they colonized, that says something. After the First World War, PNG was ripped from its nominal German ‘owners’, but no one else wanted the place. So, of course, they gave it to the Australians. It was thirty years and another war before we actually made contact. 1940s Australia was as ‘settled’ as it’d ever be; the cities were bustling and the interior was mapped. The kind of explorer who two centuries before would be heading to new continents had to console himself with Pacific islands. Console he did. The native peoples of the PNG coasts were hostile enough to the wannabe-colonialists that the Australians, flying planes overhead, were the first people to discover that the island’s inland was populated too. No one had broken through on land. In all this deep and angry rainforest, the Fore were the furthest out. They lived far into the island’s mountainous interior; DTM describes their territory as “nearly vertical”. Calling people primitives is a bit passe these days for understandable reasons, but no other term comes to mind. The Fore had no name for themselves; we call them by an exonym, “the people to the south”. They weren’t, to be clear, hunter-gatherers – they were slash-and-burn agriculturalists, but very well-fed ones. Despite the tendency in grain-focused cultures for poor agriculturalists to be stunted/malnourished, the Fore were a remarkably healthy people. Well, except for the famous bit. The first remarkable thing about the Fore was just how quickly they wanted to assimilate. Most PNG tribes weren’t particularly enthused by Western offers of injections/tractors/radios/Christianity. Yet as soon as the Australians arrived, the Fore made ceasefires in their wars with other tribes, volunteered to help large-scale Australian projects on the coast, started planting and trading coffee, and enthusiastically participated in censuses. It’s the only first-contact narrative I’ve seen where the colonizers were concerned about how badly the other guys wanted to be colonized. The next was the one that got their names in the history books. Australian officials started to notice a remarkable lack of women in Fore camps. Some tribes sequestered their women, particularly when Westerners were around, so at first they thought nothing of it. The high rate of unpartnered young men, though, was way out of PNG norms. DTM tells this part fantastically. The Fore chapters drip with the dread of dramatic irony. When the first breakthrough comes, you have to catch your breath: “Tiny” Carey noted something in the middle of August 1950 that deepened this mystery. He noticed that near the village of Henganofi there had been an unusual number of deaths. “It appears,” he wrote his superiors, “natives suffer from stomach trouble, get violent shivering, as with the ague, and die fairly rapidly.” [...] McArthur investigated a little more [...] One day in August 1953 he ran into more of the shivering people Tiny Carey had seen several years before: “Nearing one of the dwellings, I observed a small girl sitting down beside a fire. She was shivering violently and her head was jerking spasmodically from side to side.” It would be quite some time before anyone figured out what caused it – but the problem, as DTM notes, was that its cause wasn’t possible. Everyone priored that the weird undescribed disease in the Fore lands was some nocebo sorcery-sickness. Vincent Zigas, the first actual doctor sent to work with the Fore, tried to placebo-effect them and failed miserably: On the way, Apekono stopped at a hut and showed Zigas his first kuru victim. “On the ground in the far corner sat a woman of about thirty,” the doctor wrote. “She looked odd, not ill, rather emaciated, looking up with blank eyes with a mask-like expression. There was an occasional fine tremor of her head and trunk, as if she were shivering from cold, though the day was very warm.” It was almost exactly the tableau McArthur had witnessed in 1953. Zigas, though, was a doctor. He could do more than look—or so he thought: “I decided I might as well try my own variety of magic,” he remembered. He rubbed Sloan’s Liniment, a balm for sore muscles, on her and declared to her family and his guide: “The sorcerer has put a bad spirit inside the woman. I am going to burn this spirit so that it comes out of her and leaves her. You will not see the fire, but she will feel it. The bad spirit will leave her and she will not die.” The lotion penetrated the woman’s skin and she writhed in pain. “Get up! Walk!” Zigas commanded theatrically. “The woman struggled feebly as if to rise, then, exhausted, started to tremble more violently, making a sound of foolish laughter, akin to a titter.” That evening Apekono asked Zigas not to try to cure any more kuru victims; “Don’t use your magic medicine anymore. It will not win our strong sorcery.” This was a disaster. The Fore were so cooperative precisely because they hoped “Western magic” could conquer theirs. As it became clear it couldn’t, they turned hostile. The Australians had hoped to “modernize a Stone Age people”; now all their subjects were dropping dead before their eyes, from what they could only assume was a “hysterical reaction” to colonization itself. So, to solve this, they needed a batshit insane American. Carleton Gajdusek is one of the characters who dominates The Family That Couldn’t Sleep. He couldn’t not. You could put him in a car commercial and he’d dominate it. Gajdusek was a physician with a rare, intense combination of science and practice. He was a romanticist, a field worker, and a lover of everything strange. He’d been an army doctor, a government conspiracy-cover-upper, and a postdoc under Linus Pauling who described his intent as “to straighten out Pauling’s ideas about proteins”. He hated civilization, in a slightly-to-Ted’s-centre sense, and was passionate about “primitives and isolates”. He jumped at the chance to work in Papua New Guinea; he planned to conduct a multi-site study on child development in such cultures, and relished the opportunity to live in a “primitive” environment himself. He did all this so he could rape kids. Oh, he did it for the scientific curiosity and love of medicine, but he also did it so he could rape kids. Gajdusek was a pedophile in the actual-lifelong-exclusive-paraphilia sense, as opposed to the “metonym for child molester” sense. Some people who roll snake-eyes on the Sexuality Dice repress it, but some are perfectly happy to act on it; Gajdusek was #2 in its fullest form, the kind of guy who believes that a well-lived life includes raping some kids. DTM doesn’t shy from this, not for a moment. It’s the first thing he tells you about Gajdusek. It couldn’t not be; you couldn’t talk about why he went to PNG otherwise. When Gajdusek landed in PNG, he first found the place too civilized. He’d been promised a land of “cannibal savages” – where were they? After some traipsing, he found them, right where he was promised. The Fore were perfect for Gajdusek. They had some kind of medical mystery that’d been lost on everyone else. They ate each other, in exactly the way he loved detailing in his diaries (“”Women and children, particularly, partake of the human flesh,” he noted with pleasure”). As kuru cases popped up, he aggressively recorded them. He wrote lovingly detailed notes that he sent back to his Australian advisor. He wrote with intensity, with exclamation marks, with the joie de vivre of a man just where he wanted to be. Gajdusek smothered the Fore with ‘cures’ that never worked, but they didn’t get angry at him. As DTM dryly puts it: “Their children trusted him, and that was enough for them.” At some point, someone suggested sending an anthropologist...or an epidemiologist...or literally anyone with more credentials than Gajdusek and Zigas3. Gajdusek threw a shitfit, convinced this one-and-a-half-man team was enough to Solve The Problem Forever. But he got bored eventually – running off with another tribe with, as his diary notes at length, an apparent custom of youths ritually fellating older men – and Zigas, I dunno, the book neglects him a bit here. So they managed to sneak in some anthropologists. The husband-and-wife team of Robert Glasse and Shirley Lindenbaum4 were the first involved parties to give a shit about the Fore as people, rather than as colonial subjects/medical mysteries/walking sex toys. What they uncovered was fascinating. The Fore were cannibals, yes, but they were recent cannibals. They didn’t have an ancient tradition of eating their dead, like the other visitors assumed. They happened to be in contact with some cannibal groups, and after a Fore man died of “sorcery”, they thought: well, what would happen if we ate him? “People tasting it expressed their approval. ‘”This is sweet,” they said, “What is the matter with us, are we mad? Here is good food and we have neglected to eat it.”” If not for the wild coincidence that the first Fore cannibalism victim had a prion disease, kuru would never have existed. Glasse and Lindenbaum started to put together the pieces. They’d been sent down to rule out a genetic explanation – to track the kinship ties of the Fore and see how the disease ran through families. It didn’t run through families in any coherent sense, but it sure did run through cannibalism. The clincher was the age distribution. The Fore, ever enthused by colonialism, quit eating each other as soon as the Australians arrived. Children stopped dying of kuru shortly after; they simply weren’t exposed to the infectious agent. The couple sent the news to Gajdusek, who was off raping kids somewhere else. In the next part of the book, DTM runs through Gajdusek’s many conjectures of kuru’s cause – more like sketches or abstract paintings than like true hypotheses. Gajdusek was annoyed that someone else was doing something he “totally could’ve done”, and even more annoyed that another lab was running similar experiments – an attempt at a vaccine for a particular sheep disease had accidentally created a prion generator. But he was happy to swoop in and claim the credit for what he was starting to think of as “slow viruses”, an infection that somehow lays dormant for years. DTM portrays Gajdusek perfectly, in that “real life has no need for verisimilitude” way. Gajdusek was at once a brilliant man, an all-consuming narcissist, an entertaining character, and a monster beyond redemption. A lesser book might pick one or two. The Family That Couldn’t Sleep portrays him as all four, and on a personality level (as opposed to a scientific one), the Gajdusek-focused parts are some of the most gripping. --------------------------------------------------------- Outside of the jumps between the Venetian family and everything else, The Family That Couldn’t Sleep is not siloed. The narratives of all prion diseases are deeply intertwined. This is what makes it a great book. It’s 300 pages of dramatic irony. You read the whole thing, waiting for the eureka moment – the point everyone realizes they’re looking at the same cause. It does, however, make it a tad difficult to review or synopsize. The book’s story is so weird – and, often, so at odds with conventional wisdom that trickles down about the Fore et al – that you have to recap quite a bit, and the book steadfastly resists recapping. The next couple chapters after we depart from Gajdusek’s credit-claiming are mostly about experiments with various prion diseases. They’re scientifically fascinating. Unlike some medical-books-for-general-audiences (cough, How Not to Study a Disease), DTM never talks down to the reader. He assumes someone reading a 300-page book about prions is smart and wants to learn about prions. He also has – you can feel it in his words – the agonizing experience of spending his life on the other side of the doctor’s desk, trying to beat into whoever he’s talking to that no, seriously, you don’t need to lie to him or try explain a complex disease at a fourth-grade level. The first prion disease studied was scrapie. Scrapie was a big deal – it starved and killed large shares of British sheep flocks, making it a serious economic problem. Veterinary researchers had tried to prevent or cure it for centuries. It was a veritable graveyard of ambitions: Quintessential was D. R. Wilson at the Moredun Institute in Scotland, who worked in the middle of the last century for more than a decade trying, with mounting frustration, to kill the scrapie agent. He found that it survived desiccation; dosing with chloroform, phenol, and formalin; ultraviolet light; and cooking at 100 degrees centigrade for thirty minutes. The scrapie researcher Alan Dickinson told me he remembered Wilson at the end of his career as “very, very, very quiet. Of course, that was after his breakdown.” “Now it is our turn to study prions. Perhaps we should approach the subject cautiously.” The problem, as DTM explains, is that prion diseases were impossible. They violated 20th-century understandings of biology. Proteins “were no more alive, and no more infectious, than bone”. Prion diseases seemed to have too many causes – genetic, infectious, and sporadic. They looked infection-like in some ways, but patients didn’t produce virus antibodies. Sheep exposed to scrapie, or chimps infected with kuru, took years to develop symptoms. Their facts did not fit together. In the 1960s, people started wondering. The unifying trait of prion agents was that they had to be denatured to be destroyed. Was this a particularly small virus defined by its protein coating? Or – even more outre – was it pure protein, no DNA at all? No one could figure out quite how the latter worked, but it was tempting. Gajdusek, by now a major figure in this field, kept a foot in both worlds. He didn’t want to stake his reputation on a no-DNA hypothesis, but he certainly sympathized. Enter Prusiner. Stanley Prusiner was Gajdusek’s counterpart. Where Gajdusek seemed permanently manic, Prusiner was deliberate and exacting. He entered Gajdusek’s “slow viruses” field in the early 1970s after a chance encounter with a CJD patient. He relished the laboratory in a way Gajdusek didn’t at all, and set out to optimize the hell out of his projects. Prusiner set out to isolate the smallest infectious particle in the scrapie agent. He injected tons of hamsters (hamsters got sick faster than mice) with increasingly tiny scrapie proteins, hoping to determine whether the Minimum Viable Scrapie was DNA. By the mid-1980s, he’d produced something so small it couldn’t possibly be a virus. Denaturing it destroyed it; exposing it to nucleic acid dissolvers actually made it stronger. Emboldened by this discovery, Prusiner set out to anoint himself the King of Prions. Here emerges something of a Voldemort-Umbridge distinction – the difference between cartoonish villainy and banal evil. Gajdusek is a bad guy because he rapes kids. Prusiner is a bad guy because he is the most grotesque stereotype of the Advisor/Peer Reviewer from Hell made flesh. Everything Prusiner did was to build his reputation atop a pile of skulls. When recruited as a peer reviewer for other prion papers, he wrote negative reviews to undermine their authors. He worked his grad students to the bone and intentionally destroyed their careers, telling them he’d “ruin them” if they entered prion research as competitors. He lied about the origin of the protein-only hypothesis, claiming he originated it a decade after it was actually conjectured. But hey, he was good at getting grants. I was surprised reading a lot of this, because for all the time I’ve been aware of it, the cause of prion disease has seemed settled. “Oh yeah, it’s a protein that gets all fucked up.” But DTM goes through just how unsettled it was right up through to The Family That Couldn’t Sleep’s publication. Serious confirmation only arrived a couple years later. Many people were deeply critical of the prion hypothesis – often, it seemed, because they loathed Prusiner too much to go along. Throughout the book, he cuts an uncharismatic figure. Gajdusek and Prusiner both won the Nobel for discovering prions, decades apart. This tells you something – the “discovery” of prions can be construed quite a few ways. Gajdusek formulated the hypothesis; Prusiner proved it. Gajdusek was grievously offended by Prusiner’s Nobel, perceiving his rival – not inaccurately – as a follower who never originated any ideas of his own. But Gajdusek was offended from a federal prison cell, so how’d that work out for him? Fascinating as all this is, no one published a book about prions in the mid-2000s because it was about kuru or FFI. They published books about prions because teenagers were dying, and people wanted to know why. DTM lays the seeds for part 3 – the mad cow section – in part 1. This is a discussion of scrapie, the longstanding prion disease of sheep. Scrapie was a medical mystery for centuries (remember poor D. R. Wilson), precisely because of the intuitive implausibility of prions. The scrapie chapter is a great history-of-science piece, covering the agricultural productivity revolutions of the 18th century, the surfeit of bizarre origins veterinarians concocted, and the treatments that never worked. Scrapie is not transmissible to humans – well, we hope. It’s concerningly transmissible to primates. But it’s been around for a long, long time, and it doesn’t epidemiologically look like humans get it...we hope. Anyway, you ever tried to generalize from one example? The British government did! In the mid-1980s, strange reports started coming out of the UK’s farms. Farmers were describing a new disease where dairy cows – incredibly docile creatures, under normal circumstances – turned hostile, kicking them as they went into the milking stalls. The symptoms looked to all the world like scrapie. Epidemiologists tracing the outbreaks found a unifying link with “cake” – animal protein feed sweetened with molasses. The scrapie-like symptoms must have traced to an infected sheep. But scrapie doesn’t transmit to humans, so it must be okay to keep slaughtering them, right? We all know how this ended. The best term for the British response to the mad cow outbreak is “cacklingly evil conspiracy”. The agricultural industry really, really didn’t need a huge zoonotic outbreak – so it decided it didn’t have one. They first suppressed all mentions that the disease looked like scrapie, then – when this became impossible – hyped up that scrapie doesn’t transmit to humans, so there’s nothing to worry about. The formal name of the disease, “bovine spongiform encephalopathy”, was supposedly chosen to optimize for unfamiliarity – it wouldn’t fit well in a headline. They emphasized, extensively, that there was nothing to worry about. Ever. At some point, people started asking questions. If there was nothing to worry about, why was the agricultural industry panicking so hard? As things became ever more worry-inducing, this turned down ludicrously twisting paths: Meanwhile, the Southwood Working Party and the experts who advised it were learning on the job. They learned, for instance, that the BSE agent entered the animal through the mouth and then followed the digestive tract into the organs that try to filter out infections—the tonsils, the guts, and the spleen—and from there traveled into the peripheral and central nervous system, and finally arrived at the brain. They also learned that pasties, meat pies, and even some baby foods contained tissues from a lot of those organs. So the Southwood Working Party recommended banning these organs, but only from baby food. This started a chain reaction of consumer doubt: if infected cow organs were unsafe for babies, how could they be good for adults? The government then banned offal, as the organs were collectively called, in all human food but gave the industry a grace period to get it out of the feed supply. Then pet food manufacturers began to wonder if what drove cows mad might not also drive dogs, cats, and parrots mad. The feed they sold came from concentrate made of the same sick animals that had previously made up the meat and bone meal farmers used. Their trade group decided to put a similar ban in place—immediately. So for five months it was safer to be a dog than a human in Britain. DTM spends pretty much this whole section of the book making fun of the British government. To be fair, they deserved it. They killed hundreds of kids in agonizing and preventable ways – they could take some ribbing. This is all throughout the mid-1980s to early-mid 1990s. Through this period, it wasn’t yet clear that mad cow could spread to humans. The panic was clear, and deserved, but it didn’t yet have a match for its powder keg. It would alight. The first suspected case of vCJD – human mad cow – was in 1994. Fifteen-year-old Vicky Rimmer developed a sudden, strange disease. Doctors gave her months to live...until she died in 1998. A couple other suspected cases trickled down through the mid-90s, including a young man who made meat pies for a living, whose grieving mother received a letter from the Prime Minister that “humans do NOT get mad cow disease”. (That must’ve been fun.) Soon, they couldn’t deny it any longer. On March 20, 1996, Stephen Dorrell, the health secretary, stood up in Parliament to announce the news that had already appeared as a tentative conclusion in scientific journals and as rumor in newspapers for the previous two years: British beef was killing British teenagers. The first confirmed death was that of Stephen Churchill, a nineteen-year-old student from Wiltshire, who died in May 1995. Back in 1989, at the Southwood Working Party’s suggestion, the government had set up a surveillance unit in Edinburgh to watch for any evidence that BSE had crossed to humans. One worry had been that if BSE passed to humans, how would anyone know it? How would you recognize something you had never seen? It turned out to be easy: Churchill and the nine other teenagers who had gotten sick had spectacular amyloid plaques in their brains, chunks of dead protein almost visible to the naked eye. If sporadic CJD was a whisper, BSE-caused prion disease was a shout. The investigators sat open-mouthed looking at slides whose damage, they feared, portended the most severe epidemic in modern British history. This part of the book is not fun. It lacks the insane personalities and duelling careers of the other entries. It is an honest chronology of the vCJD epidemic – a gruesome failure of the agricultural industry, the one system that everyone is vulnerable to. The government and industry had completely violated their duty of care to citizens and consumers. They were paying the price. No one would buy British beef anymore – not while they watched their children die. Now here’s the thing: this is ethnography, not historiography. The Family That Couldn’t Sleep is a book from the mid-2000s. The epidemic was not at all in the rear view mirror. There were piles of unanswered questions that DTM constantly alludes to. We have eighteen years more hindsight than he did then. What do we know now? --------------------------------------------------------- In 2006, the vCJD epidemic looked like it was going to be a lot better than the worst fears. BSE itself was a huge problem for the cattle industry, but honestly, no one is too sympathetic to the cattle industry. People were not going to die in anywhere near the numbers believed. We had all sorts of reassuring data coming out about this, which DTM chronicles. We were learning that only some genotypes seemed susceptible to vCJD. We didn’t see any older people die of the disease. We were seeing numbers drop, such that vCJD must have a pretty short incubation period. Anyway, all of this is wrong! The Family That Couldn’t Sleep was written in the candidate gene era. Back then, the nascent field of human genetics was sure it was about to Solve Polygenism. Yes, the simple Mendelian monogenic patterns popular a few decades back clearly didn’t apply to common diseases, but how many variants could there be? We were about to discover the five genes influencing 20% of Alzheimer’s risk each, the five genes influencing 20% of heart disease risk each, etc., and once we were done we’d just do gene therapy and cure Alzheimer’s. A paper on autism genetics from 1999 was so outre as to speculate there might be as many as fifteen genes involved. The fact we are now using the term “omnigenic model” should tell you roughly how well this worked out. Do you remember SNPedia? If you were a 2014 Slate Star Codex reader, you might. 2014 was still pretty candidate gene. People were out there publishing papers saying a single variant could increase your life expectancy by 15 years. SNPedia was a site that beautifully categorized all of these, so you could do 23andme or whatever, look up your results on SNPedia, and make horrible life choices.5 It was eventually bought out by one of the consumer DNA companies, so no one ever edited it again, making it a great time capsule of early-mid 2010s behavioural/medical genetics takes. SNPedia will excitedly explain to you that common genetic variants make you immune to vCJD. They cite a 2009 post from the now-archived 23andme blog titled “No Good Evidence That Potential Pool of Mad Cow Disease Victims Is Expanding”, explaining how fears of late-onset vCJD are clearly debunked by new Scientific Knowledge. Everyone who developed vCJD in the 1990s and 2000s had an M/M genotype in a particular part of the PRNP prion gene, so the roughly half the population with M/V or V/V genotypes were immune. The Family That Couldn’t Sleep buys this, too. In fact, it buys it in an even more agonizingly 2000s way. The first sign that transmissible prion diseases weren’t genotype-restricted should’ve been the growth hormone kids. You might have heard this story – from the late 1950s through mid-1980s, human growth hormone produced from brain tissue was used as a treatment for pituitary dwarfism, until it turned out to spread CJD if the originating brain was infected. DTM discusses this, to set the scene for the genetics thing. He mentions what was the state of the art at the time – that a disproportionate share of both the growth hormone kids and sporadic CJD cases were V/V homozygotes. This, uh – so the book was written in the mid-2000s, yeah? Yeah. The conclusion DTM drew – and this was a common conclusion at the time – was that homozygosity somehow made you more vulnerable to CJD, and M/M homozygosity made you vulnerable to BSE-borne CJD in particular. We cannot criticise the author for not predicting the future, but we live in the future, and can say how this worked out. Turns out, nope, M/V heterozygotes totally get vCJD. After a British man in his 30s died of CJD in 2016, he was found to have vCJD and an M/V genotype. He was tested for vCJD only because he was exceptionally young for someone with a sporadic prion disease – meaning people developing it later in life would be missed6. Did you know up to 1 in 2000 people in the UK have latent vCJD? There is one line in The Family That Couldn’t Sleep that stopped me dead in my tracks when I read it: What happens to the Italian family in the end depends less on their own actions than on the world’s interest in prion diseases, which they cannot control. If lots of people are afraid of getting variant CJD, the family benefits. If fear of prion disease goes the way of the fear of swine flu or Ebola, then they will be orphaned again. THIS BOOK IS FROM 2006! Three years before the swine flu pandemic! Eight years before the Ebola pandemic! “If you’re looking for a sign, this is it.” --------------------------------------------------------- The last section of The Family That Couldn’t Sleep addresses BSE fears in America and a nascent internet subculture DTM calls “Creutzfeldt Jakobins” – people who track American CJD cases, trying to spot vCJD patterns. When reading his description of the Creutzfeldt Jakobins, my mind constantly, uncontrollably turned to covid. Here it was – an online community of people deeply skeptical about a disease’s official story, tracking every contradiction, every implausibility, every statistic that failed to apply to the individual. Self-described “redneck hippies” and “soccer mom Republicans” teaming up to find the truth hidden behind an impossible world. You know what they’re doing now. I’ve always combined a deep interest in medicine with a healthy distrust for it. People who are constitutionally inquisitive, anti-authoritarian, and suspicious about official narratives tend to end up skeptical of at least some mainstream claims in the field. This is not to say I think you should take bleach enemas or something, just that I understand the impulse behind concluding the US government was covering up a local vCJD wave. Traditionally, sporadic prion diseases are said to have a prevalence of one in a million. (Hold on to that for a second.) The last section of the book is a chronology of Americans finding bizarrely more than one in a million of their friends dying of sporadic CJD, often at inexplicably young ages, sometimes in geographical clusters. This is understandably suspicious. Then DTM goes on to reassure us by saying none of these cases were confirmed to have an M/M genotype, which OH GOD OH FUCK A number of high-profile people in the prion world, including Gajdusek, are clarified as not believing sporadic prion diseases exist. You get the impression DTM doesn’t, either. Now, how common are prion diseases? Eric Vallabh Minikel has an answer for you! Eric and his wife Sonia are prion researchers from a rather unique background – after Sonia was diagnosed as having a single-gene mutation with ~100% penetrance for prion disease, they left their previous jobs to dedicate their lives to curing it. It turns out, when you run the numbers, you get not one in a million but 1 in 5000 people dying of prion diseases. This is best described as “nightmarishly high”. I’m normed on genetic disorders. A genetic disorder that affects one in five thousand people is pretty common! I have known, in person, completely unselected, just from “random people I’ve met in my life in a non-medical context”, someone with a ~1/250k syndrome and someone with a ~1/50k-100k syndrome. I don’t think anyone in my extended family knows someone who died of a prion disease. I feel like it would’ve come up if they did! Prion diseases have distinctive phenotypes. Not distinctive enough, apparently, to avoid a lot of CJD being misdiagnosed as Alzheimer’s – but diagnosis is consistently insane. Something DTM reiterates throughout The Family That Couldn’t Sleep is just what prion dementia looks like. The characteristic dementia in prion diseases spares something – “self” or “recognition” or “reflection” – that is not spared by Alzheimer’s, or by most common dementias. Shouldn’t this be, uh, noticeable?7 They kill rapidly, often over the course of months, and often onset in midlife. ALS shares this pattern and is way, way more common than prion diseases; you hear about ALS far more in the “disorder people actually have” sense. What am I missing here? Anyway: 1 in 2000 prevalence of latent vCJD in the UK + extreme lack of clarity over whether scrapie is human-transmissible + blood donations spread vCJD + sporadic CJD prevalence keeps going up = ??? (Yes, I am annoyed that most countries have lifted their ban on UK blood donors, thank you for asking!) --------------------------------------------------------- But back to the book. The “American chapter” is one-third about the country’s response to vCJD, one-third about the Creutzfeldt Jakobins, and one-third about chronic wasting disease. The last part is the most interesting. Chronic wasting disease is a prion disease of deer. Like scrapie, it “probably, we hope” isn’t human-transmissible (eat venison at your own risk). Under natural circumstances, deer shouldn’t get prion diseases: A prion plague should not be possible among ruminants in the wild. Deer are not cannibals, as the cows that spread BSE were forced to be; and, because deer and elk are not domesticated, they do not have enough contact with one another to spread a prion infection the way sheep are thought to spread scrapie. But deer do not live as they used to live, humans having once again brought their ambitions to bear on the natural course of things. The Family That Couldn’t Sleep is a book of medical anthropology. Anthropology of the Veneto, anthropology of Papua New Guinea, anthropology of 1990s Britain. Here, it is an anthropology of America. Americans, having won the world, still fight to win their own backyard. The North American continent is geographically diverse, cutting through rain-snow-shine, mountains jutting over plains, cities sprawling into wilderness, habitations criss-cross dotted with surprisingly few empty zones. Go somewhere like Denver, the Mile High City, three million people fighting against nature. Few other countries have anything like this; geographically vast polities usually have uninhabitable blocks. Australians are twenty-five million people clustered against the shore. It still surprises me, after all this time, how every US state has a meaningful city8. Midcentury Denver, growing and sprawling out across its mountains, started to run into their natural inhabitants – deer. Starvation is one way nature adjusts the deer population to the available food supply. People did not usually see this process, but in the 1950s and 1960s Colorado became more densely settled, reducing forested areas and forcing deer to look longer and harder for food. At the same time, the state enacted conservation laws, limiting when and where hunters could shoot. Soon emaciated deer began wandering onto the lawns and through suburban streets looking for a meal. People began to feed them, only to find that they died anyway. They would drop dead by haystacks, along highways, and in flower beds. In the late 1960s, a young biologist named Gene Schoonveld tried to figure out why the deer starved even when they were fed.9 He deprived some deer of food for a while, “[h]e cut windows in their stomachs to see what went on inside, and then he began to feed them”. While this was going on, he had a control group of healthy, well-fed deer as backups in case anything went wrong. It did...but not to the experimental group. The pen in which the deer were kept also housed sheep, which, it turned out, were scrapie carriers. The deer somehow acquired scrapie – there’s a huge unanswered question here, which DTM doesn’t address. How did they get scrapie? They didn’t eat the sheep, presumably. Did it somehow transmit from casual contact? This is not supposed to happen. And yet: the deer in the sheep pen started dying of a mysterious scrapie-like disease, one never reported before, that would go on to infect thousands. These deer were released into the wild. Ten years later, the first reports of chronic wasting disease came out. The disease spread across deer and elk in the western half of the country. By the turn of the millennium, cases were exploding – and lost all geographical restriction. DTM can report up to 2005, at which point it was floating around Upstate New York. This kind of spread doesn’t track natural deer migration. That’s irrelevant, because nothing about CWD’s spread is natural. We shift gears into an anthropology of the American hunter. The hunter wants to shoot the most impressive buck, to bag himself one with as many “points” as possible – one whose antlers branch out most. A “ten-point buck” has five branches on each horn: Original by Ric McArthur Nature doesn’t make enough bucks with perfectly symmetrical ten-point horns. To fill the demand, the market had to step in. Thus was born the deer farm industry, which raises captive deer in better genetic and nutritional conditions than Nature permits, then ships them across the country so hunters who couldn’t get legit ten-point bucks get the taxidermy piece for their wall. These are controversial amongst hunters and illegal in numerous states – but the industry is big enough to spread CWD. (The kind of hunter who needs a deer shipped to his house is the kind of hunter who will fumble killing it.) Another problem is supplemental feeding – leaving out protein-enriched food for deer to eat. This produces “trophy class animals at an earlier age”, but again, what’s in that protein? (“It is much like feeding your cows 41 percent protein cottonseed cake during the winter to raise the protein level in the cow’s diet to a level that will maintain acceptable production”, says that article from 1991.)10 The book segues into a vignette. CWD was new in Wisconsin in the early 2000s, and the state’s Department of Natural Resources was optimistic it could eradicate it. In a state with a love of hunting, you could, in theory, recruit people to kill every single deer in a 400-square-mile radius: In many states, the state would have had to call out the National Guard for such an onslaught, but hunting is a passion in Wisconsin. Hunters shoot 450,000 deer every year, more than in any other state. “I’m looking for ardent hunters to help us, unless fear or their wives keep them away,” one DNR official told a Milwaukee magazine. The state extended the normal hunting season and waived the usual limit of one buck per hunter, and the hunters came out in force. The whole affair was gruesome – one official called it “hunting for slob hunters”. If you’re trying to eradicate a prion disease, you can’t very well let people take the carcasses home to eat. Bodies piled up in control stations, decomposition mingling with bleach. The 2002 hunt established a base rate of 2% for chronic wasting disease in Wisconsin deer, with the most affected areas getting up to 10%. Further hunts in 2003, 2004, and 2005 spread to wider and wider areas – and didn’t move the needle one bit. This is to say that CWD is quite a bit more common in the American deer population than BSE ever was in British cattle. Since publication, it’s popped up in Norway and South Korea. Notably, Norway doesn’t allow for the import of cervids, raising numerous questions about how it got there. There are no unambiguous cases of CWD transmission to humans, and in vivo/in vitro primate studies have mixed results. There sure are some unusually young hunters with sporadic CJD, though. But don’t worry, most of them aren’t M/M homozygotes! There is an absolute ton going on in this book. I’ve had to skim over whole sections. Parts that couldn’t be easily slotted into a narrative review include: When Gajdusek was invited to a party at Prusiner’s house, he was horrified to find his rival had purchased hundreds of New Guinean statues – all with the genitals removed.

Inline links: 2, Lyttle Lytton, 3, 4, a couple years later, concerningly transmissible to primates, omnigenic model, you might, 5, SNPedia, a 2009 post, https://substackcdn.com/image/fetch/$s_!N93S!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fced2eca3-ec58-40b8-8c13-debdb559ab8f_651x601.png, Yeah., nope, M/V heterozygotes totally get vCJD, 6, up to 1 in 2000 people in the UK have latent vCJD, bleach enemas, has an answer for you, 7, blood donations spread vCJD, going, up, 8, 9, not supposed to happen, https://substackcdn.com/image/fetch/$s_!0J8B!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F2a64b287-a7c6-4d82-bbe1-da949fc93118_1024x683.png, Ric McArthur, controversial, amongst, hunters, illegal in numerous states, trophy class animals at an earlier age, 10, Norway, South Korea, mixed results, sure are

Yeah. The conclusion DTM drew – and this was a common conclusion at the time – was that homozygosity somehow made you more vulnerable to CJD, and M/M homozygosity made you vulnerable to BSE-borne CJD in particular. We cannot criticise the author for not predicting the future, but we live in the future, and can say how this worked out. Turns out, nope, M/V heterozygotes totally get vCJD. After a British man in his 30s died of CJD in 2016, he was found to have vCJD and an M/V genotype. He was tested for vCJD only because he was exceptionally young for someone with a sporadic prion disease – meaning people developing it later in life would be missed6. Did you know up to 1 in 2000 people in the UK have latent vCJD? There is one line in The Family That Couldn’t Sleep that stopped me dead in my tracks when I read it: What happens to the Italian family in the end depends less on their own actions than on the world’s interest in prion diseases, which they cannot control. If lots of people are afraid of getting variant CJD, the family benefits. If fear of prion disease goes the way of the fear of swine flu or Ebola, then they will be orphaned again. THIS BOOK IS FROM 2006! Three years before the swine flu pandemic! Eight years before the Ebola pandemic! “If you’re looking for a sign, this is it.” --------------------------------------------------------- The last section of The Family That Couldn’t Sleep addresses BSE fears in America and a nascent internet subculture DTM calls “Creutzfeldt Jakobins” – people who track American CJD cases, trying to spot vCJD patterns. When reading his description of the Creutzfeldt Jakobins, my mind constantly, uncontrollably turned to covid. Here it was – an online community of people deeply skeptical about a disease’s official story, tracking every contradiction, every implausibility, every statistic that failed to apply to the individual. Self-described “redneck hippies” and “soccer mom Republicans” teaming up to find the truth hidden behind an impossible world. You know what they’re doing now. I’ve always combined a deep interest in medicine with a healthy distrust for it. People who are constitutionally inquisitive, anti-authoritarian, and suspicious about official narratives tend to end up skeptical of at least some mainstream claims in the field. This is not to say I think you should take bleach enemas or something, just that I understand the impulse behind concluding the US government was covering up a local vCJD wave. Traditionally, sporadic prion diseases are said to have a prevalence of one in a million. (Hold on to that for a second.) The last section of the book is a chronology of Americans finding bizarrely more than one in a million of their friends dying of sporadic CJD, often at inexplicably young ages, sometimes in geographical clusters. This is understandably suspicious. Then DTM goes on to reassure us by saying none of these cases were confirmed to have an M/M genotype, which OH GOD OH FUCK A number of high-profile people in the prion world, including Gajdusek, are clarified as not believing sporadic prion diseases exist. You get the impression DTM doesn’t, either. Now, how common are prion diseases? Eric Vallabh Minikel has an answer for you! Eric and his wife Sonia are prion researchers from a rather unique background – after Sonia was diagnosed as having a single-gene mutation with ~100% penetrance for prion disease, they left their previous jobs to dedicate their lives to curing it. It turns out, when you run the numbers, you get not one in a million but 1 in 5000 people dying of prion diseases. This is best described as “nightmarishly high”. I’m normed on genetic disorders. A genetic disorder that affects one in five thousand people is pretty common! I have known, in person, completely unselected, just from “random people I’ve met in my life in a non-medical context”, someone with a ~1/250k syndrome and someone with a ~1/50k-100k syndrome. I don’t think anyone in my extended family knows someone who died of a prion disease. I feel like it would’ve come up if they did! Prion diseases have distinctive phenotypes. Not distinctive enough, apparently, to avoid a lot of CJD being misdiagnosed as Alzheimer’s – but diagnosis is consistently insane. Something DTM reiterates throughout The Family That Couldn’t Sleep is just what prion dementia looks like. The characteristic dementia in prion diseases spares something – “self” or “recognition” or “reflection” – that is not spared by Alzheimer’s, or by most common dementias. Shouldn’t this be, uh, noticeable?7 They kill rapidly, often over the course of months, and often onset in midlife. ALS shares this pattern and is way, way more common than prion diseases; you hear about ALS far more in the “disorder people actually have” sense. What am I missing here? Anyway: 1 in 2000 prevalence of latent vCJD in the UK + extreme lack of clarity over whether scrapie is human-transmissible + blood donations spread vCJD + sporadic CJD prevalence keeps going up = ??? (Yes, I am annoyed that most countries have lifted their ban on UK blood donors, thank you for asking!) --------------------------------------------------------- But back to the book. The “American chapter” is one-third about the country’s response to vCJD, one-third about the Creutzfeldt Jakobins, and one-third about chronic wasting disease. The last part is the most interesting. Chronic wasting disease is a prion disease of deer. Like scrapie, it “probably, we hope” isn’t human-transmissible (eat venison at your own risk). Under natural circumstances, deer shouldn’t get prion diseases: A prion plague should not be possible among ruminants in the wild. Deer are not cannibals, as the cows that spread BSE were forced to be; and, because deer and elk are not domesticated, they do not have enough contact with one another to spread a prion infection the way sheep are thought to spread scrapie. But deer do not live as they used to live, humans having once again brought their ambitions to bear on the natural course of things. The Family That Couldn’t Sleep is a book of medical anthropology. Anthropology of the Veneto, anthropology of Papua New Guinea, anthropology of 1990s Britain. Here, it is an anthropology of America. Americans, having won the world, still fight to win their own backyard. The North American continent is geographically diverse, cutting through rain-snow-shine, mountains jutting over plains, cities sprawling into wilderness, habitations criss-cross dotted with surprisingly few empty zones. Go somewhere like Denver, the Mile High City, three million people fighting against nature. Few other countries have anything like this; geographically vast polities usually have uninhabitable blocks. Australians are twenty-five million people clustered against the shore. It still surprises me, after all this time, how every US state has a meaningful city8. Midcentury Denver, growing and sprawling out across its mountains, started to run into their natural inhabitants – deer. Starvation is one way nature adjusts the deer population to the available food supply. People did not usually see this process, but in the 1950s and 1960s Colorado became more densely settled, reducing forested areas and forcing deer to look longer and harder for food. At the same time, the state enacted conservation laws, limiting when and where hunters could shoot. Soon emaciated deer began wandering onto the lawns and through suburban streets looking for a meal. People began to feed them, only to find that they died anyway. They would drop dead by haystacks, along highways, and in flower beds. In the late 1960s, a young biologist named Gene Schoonveld tried to figure out why the deer starved even when they were fed.9 He deprived some deer of food for a while, “[h]e cut windows in their stomachs to see what went on inside, and then he began to feed them”. While this was going on, he had a control group of healthy, well-fed deer as backups in case anything went wrong. It did...but not to the experimental group. The pen in which the deer were kept also housed sheep, which, it turned out, were scrapie carriers. The deer somehow acquired scrapie – there’s a huge unanswered question here, which DTM doesn’t address. How did they get scrapie? They didn’t eat the sheep, presumably. Did it somehow transmit from casual contact? This is not supposed to happen. And yet: the deer in the sheep pen started dying of a mysterious scrapie-like disease, one never reported before, that would go on to infect thousands. These deer were released into the wild. Ten years later, the first reports of chronic wasting disease came out. The disease spread across deer and elk in the western half of the country. By the turn of the millennium, cases were exploding – and lost all geographical restriction. DTM can report up to 2005, at which point it was floating around Upstate New York. This kind of spread doesn’t track natural deer migration. That’s irrelevant, because nothing about CWD’s spread is natural. We shift gears into an anthropology of the American hunter. The hunter wants to shoot the most impressive buck, to bag himself one with as many “points” as possible – one whose antlers branch out most. A “ten-point buck” has five branches on each horn: Original by Ric McArthur Nature doesn’t make enough bucks with perfectly symmetrical ten-point horns. To fill the demand, the market had to step in. Thus was born the deer farm industry, which raises captive deer in better genetic and nutritional conditions than Nature permits, then ships them across the country so hunters who couldn’t get legit ten-point bucks get the taxidermy piece for their wall. These are controversial amongst hunters and illegal in numerous states – but the industry is big enough to spread CWD. (The kind of hunter who needs a deer shipped to his house is the kind of hunter who will fumble killing it.) Another problem is supplemental feeding – leaving out protein-enriched food for deer to eat. This produces “trophy class animals at an earlier age”, but again, what’s in that protein? (“It is much like feeding your cows 41 percent protein cottonseed cake during the winter to raise the protein level in the cow’s diet to a level that will maintain acceptable production”, says that article from 1991.)10 The book segues into a vignette. CWD was new in Wisconsin in the early 2000s, and the state’s Department of Natural Resources was optimistic it could eradicate it. In a state with a love of hunting, you could, in theory, recruit people to kill every single deer in a 400-square-mile radius: In many states, the state would have had to call out the National Guard for such an onslaught, but hunting is a passion in Wisconsin. Hunters shoot 450,000 deer every year, more than in any other state. “I’m looking for ardent hunters to help us, unless fear or their wives keep them away,” one DNR official told a Milwaukee magazine. The state extended the normal hunting season and waived the usual limit of one buck per hunter, and the hunters came out in force. The whole affair was gruesome – one official called it “hunting for slob hunters”. If you’re trying to eradicate a prion disease, you can’t very well let people take the carcasses home to eat. Bodies piled up in control stations, decomposition mingling with bleach. The 2002 hunt established a base rate of 2% for chronic wasting disease in Wisconsin deer, with the most affected areas getting up to 10%. Further hunts in 2003, 2004, and 2005 spread to wider and wider areas – and didn’t move the needle one bit. This is to say that CWD is quite a bit more common in the American deer population than BSE ever was in British cattle. Since publication, it’s popped up in Norway and South Korea. Notably, Norway doesn’t allow for the import of cervids, raising numerous questions about how it got there. There are no unambiguous cases of CWD transmission to humans, and in vivo/in vitro primate studies have mixed results. There sure are some unusually young hunters with sporadic CJD, though. But don’t worry, most of them aren’t M/M homozygotes! There is an absolute ton going on in this book. I’ve had to skim over whole sections. Parts that couldn’t be easily slotted into a narrative review include: When Gajdusek was invited to a party at Prusiner’s house, he was horrified to find his rival had purchased hundreds of New Guinean statues – all with the genitals removed.

Inline links: Yeah., nope, M/V heterozygotes totally get vCJD, 6, up to 1 in 2000 people in the UK have latent vCJD, bleach enemas, has an answer for you, 7, blood donations spread vCJD, going, up, 8, 9, not supposed to happen, https://substackcdn.com/image/fetch/$s_!0J8B!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F2a64b287-a7c6-4d82-bbe1-da949fc93118_1024x683.png, Ric McArthur, controversial, amongst, hunters, illegal in numerous states, trophy class animals at an earlier age, 10, Norway, South Korea, mixed results, sure are

Original by Ric McArthur Nature doesn’t make enough bucks with perfectly symmetrical ten-point horns. To fill the demand, the market had to step in. Thus was born the deer farm industry, which raises captive deer in better genetic and nutritional conditions than Nature permits, then ships them across the country so hunters who couldn’t get legit ten-point bucks get the taxidermy piece for their wall. These are controversial amongst hunters and illegal in numerous states – but the industry is big enough to spread CWD. (The kind of hunter who needs a deer shipped to his house is the kind of hunter who will fumble killing it.) Another problem is supplemental feeding – leaving out protein-enriched food for deer to eat. This produces “trophy class animals at an earlier age”, but again, what’s in that protein? (“It is much like feeding your cows 41 percent protein cottonseed cake during the winter to raise the protein level in the cow’s diet to a level that will maintain acceptable production”, says that article from 1991.)10 The book segues into a vignette. CWD was new in Wisconsin in the early 2000s, and the state’s Department of Natural Resources was optimistic it could eradicate it. In a state with a love of hunting, you could, in theory, recruit people to kill every single deer in a 400-square-mile radius: In many states, the state would have had to call out the National Guard for such an onslaught, but hunting is a passion in Wisconsin. Hunters shoot 450,000 deer every year, more than in any other state. “I’m looking for ardent hunters to help us, unless fear or their wives keep them away,” one DNR official told a Milwaukee magazine. The state extended the normal hunting season and waived the usual limit of one buck per hunter, and the hunters came out in force. The whole affair was gruesome – one official called it “hunting for slob hunters”. If you’re trying to eradicate a prion disease, you can’t very well let people take the carcasses home to eat. Bodies piled up in control stations, decomposition mingling with bleach. The 2002 hunt established a base rate of 2% for chronic wasting disease in Wisconsin deer, with the most affected areas getting up to 10%. Further hunts in 2003, 2004, and 2005 spread to wider and wider areas – and didn’t move the needle one bit. This is to say that CWD is quite a bit more common in the American deer population than BSE ever was in British cattle. Since publication, it’s popped up in Norway and South Korea. Notably, Norway doesn’t allow for the import of cervids, raising numerous questions about how it got there. There are no unambiguous cases of CWD transmission to humans, and in vivo/in vitro primate studies have mixed results. There sure are some unusually young hunters with sporadic CJD, though. But don’t worry, most of them aren’t M/M homozygotes! There is an absolute ton going on in this book. I’ve had to skim over whole sections. Parts that couldn’t be easily slotted into a narrative review include: When Gajdusek was invited to a party at Prusiner’s house, he was horrified to find his rival had purchased hundreds of New Guinean statues – all with the genitals removed.

Inline links: Ric McArthur, controversial, amongst, hunters, illegal in numerous states, trophy class animals at an earlier age, 10, Norway, South Korea, mixed results, sure are

Your Book Review: How the War Was Won

August 09, 2024 · Original source

The firebombing of Japanese cities and the atomic bombings of Hiroshima and Nagasaki had an ambiguous strategic effect. American air power played a much more important role in severing Japan from the natural resources it had conquered in the early part of the war. Battles are Overrated Take another look at the conventional narrative. Almost every key event involves a battle, a period of time in a relatively localized area where combatants slugged it out to see who would occupy some bit of land or sea. To O’Brien, this focus is silly, a relic of long-ago wars in ages with far less industrial capacity. Start with theory. States fight to impose their will on another state in pursuit of some political goal. To do that requires that they achieve sufficient local military superiority that the other state can’t stop them from achieving their political goal. Nazi Germany wanted to be the new administrators of the agricultural area of the western Soviet Union. To do that, they had to evict the Soviet military, whether through direct destruction or forcing the Soviet government to withdraw their armed forces. Individual battles for control of a localized area only matter if they are a means to that end. Does the occupation or non-occupation of that point on the map affect the ability of a combatant to keep fighting? In some limited cases, yes. Battlefield victory enabled Germany to overrun France before France could really focus its productive effort on the war. After their surrender, the French could not produce weapons, and they functionally could not organize their manpower to fight the Germans. But if the German army conquered, say, a random city in the Soviet Union, like Stalingrad, Soviet production and manpower was barely affected. The war goes on. In theory, the German army could destroy so much of the Soviet military in one battle (or even a few discrete battles) that the Soviets run out of men or weapons. If there was ever a time this could have happened, it would have been the German invasion of the Soviet Union in 1941, when the Germans basically won a series of crushing victories. The problem for the Germans was that by World War II, people in the combatant countries were good at building stuff in vast quantities, and the major combatants of World War II generally had access to sufficient natural resources. Even massive armies could not destroy produced weapons systems (e.g., tanks, airplanes) on the battlefield fast enough to remove the other side’s ability to continue fighting. What could (and did) happen was the destruction of the other side’s ability to produce and distribute weapons. Sure enough, if you look at the actual data from even the largest battles, neither side really destroys a hugely significant amount of stuff. Take the Battle of Kursk—the largest tank and air battle of World War II. Wikipedia will dazzle you with the numbers of soldiers involved (millions), tanks deployed (in the ballpark of 10,000), and aircraft in the sky (in the ballpark of 5,000). In this entire vast battle that supposedly dictated the outcome of the Eastern Front, the Germans lost approximately 350 armored fighting vehicles (AFVs) during the most intense 10 days of fighting. In the two months around when the battle took place, the Germans lost 1,331 AFVs on the entire Eastern Front. In the year of the battle, 1943, the Germans built more than 12,000 AFVs. Also worth noting: they disproportionately lost older, obsolete tanks at Kursk, and built new, capable tanks. The Germans lost a very manageable amount of equipment at Kursk—less than a month’s worth of AFV production. If modern war means you cannot realistically destroy enough weapons in one battle to matter—if the largest battle of all time didn’t really matter—what did? Allied Air and Sea Operations Won the War In O’Brien’s methodology, we should look at what the Axis spent its productive effort making and consider what Allied actions slowed that productive effort. In both theaters, the answer is shocking. The Germans spent relatively little productive effort on tanks, focusing far more on aircraft, submarines, and vengeance weapons (i.e., proto-cruise missiles and rockets). The Japanese spent heavily on aircraft as well, but also a tremendous amount on freighters and oil tankers. The Allies won the war by using air power to destroy the German and Japanese capacity both to produce military equipment and to transport it to the battlefield. By 1944-45, the Germans and Japanese could not use their economies to arm and supply their armies on the battlefield, leading to their inevitable defeat. In the European war, American and British airpower: (a) directly destroyed a significant amount of productive capacity, (b) rendered remaining capacity far less efficient, (c) made it impossible for the Germans to defeat western ground forces, and (d) compelled the Germans to waste tremendous resources on air defense and exorbitant, ultimately ineffective vengeance weapons. In the Pacific, the United States used carrier-based airpower, submarines, and bomber-deployed mines to isolate Japan from the resources of the empire it conquered in 1941-42. American bombers also directly destroyed factories and transportation systems, leading to similar levels of economic dysfunction as in Germany. Amateurs Discuss Destruction; Professionals Discuss Non-Operational Losses O’Brien is at his absolute best describing the subtle factors that whittled away Axis combat power. Air and sea power created a situation where the Axis war machine simply could not function anywhere near as efficiently as it needed to. For example, after the Allied air bombings started, Germany built vast underground aircraft factories to protect production. But that move carried a host of negative side effects. To name a few: The direct cost of building new factories in inconvenient places was very manpower intensive.

Data from HtWWW, recreated to improve image quality The inefficiencies stemming from bombing ruined several would-be German technological panaceas. Germany developed the world’s first operational jet fighter, the Me-262. Lack of fuel meant there was not enough training for its pilots, and maintenance shortfalls meant that about half of the 1,400 Me-262s produced by Germany were lost outside of combat. The Germans developed a dangerous, relatively modern submarine, the Type XXI. They intended to deploy dozens in a way that the Allies would have been hard pressed to fight, but production delays meant that only one ever actually went on a mission. Allied Bombings Provoked Vastly Expensive Reactions O’Brien thoroughly documents how expensive Germany’s reaction to Allied bombings was. First, expenditures on anti-aircraft weaponry and fighter planes skyrocketed. The Germans practically denuded the Eastern Front of fighter planes to have more to throw at the bombers. By late 1944, a bare 15% of German aircraft were fighting on the Eastern Front. In the second half of 1943, significantly more concrete was devoted to the construction of protected aircraft factories in Germany than to the entire Eastern Front. The amount of concrete devoted just to protecting Hitler personally from air attack was almost a third of the entire total for fortifications on the Eastern Front Second, and perhaps even more importantly, the bombings caused Hitler to authorize the most expensive German program of the war, the V-2 rocket, with essentially no goal in mind other than the psychological importance of striking back at Allied cities. The V-2 program cost the Germans proportionally as much as the U.S. spent on the Manhattan Project. According to O’Brien, the design and construction of V-2 rockets cost as much as all German AFV construction between 1939 and 1945(!) It may be surprising to learn that the V-2s were basically irrelevant to the war. Launched primarily against UK cities, the V-2s killed several thousand civilians. However, more German slave laborers died building the V-2s than British civilians died from their use. The stupidity and expense of building the V-2 probably saved tens of thousands of lives elsewhere, which is ultimately yet another benefit of the Allied bombing campaign. O’Brien’s production-focused approach yields some surprising insights about what the Germans should have done. The most cost-effective effort was certainly the use of submarines (U-Boats) to attack American shipments of military equipment across the Atlantic Ocean. For example, data suggest that the German navy destroyed at least twice as many American aircraft in the pre-production phase by destroying resource shipments as the German air force did in combat in 1942 and 1943. Japan Was Far More Powerful Than We Usually Think O’Brien goes to great lengths to illustrate that Japan was not just a small island power easily subsumed by American production. The Japanese economy, at its peak, produced about as much as the Soviet Union. Its industrial base was mostly untouched until mid-1944. In 1943, it produced as much steel as the Soviet Union. The Japanese navy’s planes doubled between 1943 and 1944. Famously, the Soviets focused on producing tanks. The Japanese focused on freighters and oil tankers. They had to—they had gone to war to obtain natural resources by conquest away from their home islands, and to use those resources, they had to ship them back to the home islands. The problem was that once the American navy had conclusively defeated the Japanese navy (certainly no later than mid-1943), nothing could stop American submarines and carrier-based aircraft from savaging Japanese shipping. But just as the bombing of Germany weakened German production in several complementary ways, the American war on Japanese shipping caused cascading logistical problems. For example, one very successful initiative was the aerial mining of Japanese ports. The mining didn’t start until March 1945, but it still sank more tonnage than U.S. submarines did in the entire war. Beyond that, the mining forced Japanese ships to use smaller, less efficient ports with bad communications and dock facilities, reducing the value of the small amount making it through to port. The Morality of Strategic Bombing One small but noteworthy argument in HtWWW relates to the “area” bombing of German cities, the firebombing of Tokyo, and the atomic bombings of Hiroshima and Nagasaki. Usually, air power enthusiasts are apologists for the indifferent (or even intentional) bombing of Axis civilians. They portray the fire/atomic bombings as difficult, but necessary and effective. O’Brien calls that logic into question. As we’ve seen, strategic bombings that targeted specific factories or mined harbors were extremely useful. O’Brien writes, however, that civilian-centric bombing had ambiguous effects. Obviously, killing workers hurts productivity. But killing their spouses or children or destroying their houses does not immediately lead to unsolvable resource dilemmas. It is perhaps too obvious to bear mentioning, but to the extent the civilian-centric bombings were not as effective as the rest of the strategic bombing campaign, they were immoral. O’Brien does not shy away from this conclusion, and shows a commendable willingness to gore sacred cows. He writes that Arthur Harris, leader of the British bombing campaign, resisted attempts to shift bombing away from cities generally and toward fuel or transportation targets, even when the evidence was clear that bombing was more effective. He takes the unusual step of effectively calling Churchill a moral coward: From the autumn of 1944 onwards, it becomes difficult to justify any of the area attacks on German cities as important in winning the war. However, removing Harris, which might have allowed for such a change, was beyond the Churchill government’s courage. O’Brien is similarly critical of Curtis LeMay, the American general who oversaw the firebombings. In his autobiography, LeMay justified the firebombings on the vague claim that they damaged Japanese morale. His evidence was a decline in Tokyo’s population, but population tended to decline after bombing raids anyway because production was relocated after raids. O’Brien concludes: LeMay’s view of warfare was definitely a step backwards – and possibly self-defeating. His notion of causing justified destruction with little evidence beyond the physical action of destruction added an unnecessary air of irrationality to the American campaign. Another important consideration in the debate over using the atomic bomb that I had not seen before: the firebombings were declining in effectiveness over time for the obvious reason that the best targets were already gone and the remaining cities were taking better precautions. The argument that firebombings alone would drive Japan to surrender without need of the atomic bomb must account for this awkward fact. Death by Oil Austerity Oil was a particular problem for Japan. The Japanese had gone to war with the United States in no small part because the U.S. cut off oil exports to Japan. The Japanese attempted to replace U.S. oil with oil from southeast Asia. Again, this was far less efficient than the pre-war arrangements, and once the U.S. Navy shut down shipping, the Japanese had to make drastic cuts to conserve oil. Perhaps the single worst way to conserve oil was in flight training. The Japanese air forces entered a death spiral. To replace veteran flyers lost at Midway or off Guadalcanal, the Japanese parsimoniously supplied oil for limited training flight hours. This famously led to their being massacred by better-trained American pilots in the Great Marianas Turkey Shoot. Another point brilliantly made by O’Brien: reductions in fuel expenditures meant Japanese pilots did not have sufficient training in navigation. Early in the war, aircraft were delivered to forward operating bases by aircraft carriers, limiting the ability of pilots to get lost. Once the American Navy had driven Japanese carriers from the scene, Japanese pilots had to make several over water hops to fly from the home islands to forward bases. Shocking numbers were lost along the way—up to 50%. (HALF) (!!!!) (I CAN’T EMPHASIZE ENOUGH HOW CRAZY THIS IS). In addition to reduced training, Japan found another terrible way to conserve fuel: do not test engines for very long on the ground before sending single-engine fighter planes off to distant island deployments. Maintenance factors were one reason that on just one leg of the trip from Japan to forward bases, 5% of aircraft that took off from one island never landed at the next. By 1945, the Japanese economy was so desperate for fuel that the government set up more than 34,000 small stills in the home islands to distill the oil from pine needles into aviation fuel. In the European theater, the Allies specifically targeted German coal-to-oil conversion plants and Romanian oil facilities, which became far less productive. Over the course of one year, 1944, the western Allies destroyed the German energy market, and with it the German economy writ large. Data from HtWWW, recreated to improve image quality. German oil shortages caused exactly the same training problem Japan had faced, with a slightly different but similarly disastrous outcome. Japanese training and production problems led to planes not arriving where they were supposed to in fighting condition (perhaps as few as 10% were actually combat capable when they arrived!) For Germany, training shortfalls meant annihilation for their air force as inexperienced pilots were forced to fight numerically and qualitatively superior American and British pilots. German monthly aircraft lost/damaged rates increased from 52.5% in January 1944 to 96.3% in June. One particularly illuminating episode illustrates how these problems manifested for Germany. The German air force had a reserve of 800 aircraft to counter the D-Day landings. The pilots of that force were used to only flying under expert control systems in Germany (countering bombing raids). When they went to France, they had trouble navigating and often landed on the wrong fields. Ultimately, they were poorly prepared to fight. The head of German fighter command was certain that the entire reserve did not destroy even two dozen Allied aircraft. American/British Airpower Decided the Outcome of Land Battles Beyond the strategic effects of bombing, tactical airpower (i.e., airplanes attacking land forces) gave an insurmountable advantage to the western Allies’ land forces. After D-Day, the Germans had a very strong defensive position in the hedgerows of northwest France. Allied aircraft literally carpet bombed one of the strongest divisions in the German army out of existence, with 70% casualties in one day. That division would normally have approximately 200 AFVs. At the end of that one day of bombing, it had 14. The Battle of the Bulge, the last offensive by the Germans to drive back the western Allies’ advance, was almost pathetic in its hopelessness. We Americans tend to focus on the hard fighting at the outset of the battle, and the stout resistance of the 101st Airborne at Bastogne. Knowing that airpower would make their attack impossible, the Germans timed the battle for bad weather and prayed it lasted as long as possible. Prayer was really the only option. Once the skies inevitably cleared after a little over a week of bad weather, more than 2,000(!) Allied bombers destroyed the German offensive. With most logistical support wiped out, one famous German division had to abandon all its vehicles and walk back to Germany. Criticism of HtWWW as a Book: Love the Data, (Mostly) Don’t Care About the People My single biggest criticism of HtWWW is O’Brien spends a lot of time (I would estimate 20% of the book) discussing the relative importance and influence of various people in the United States and United Kingdom. The section on Doug MacArthur is worth a longer digression, which I have included below. The problem is that focusing on personnel is almost completely irrelevant to the main argument of the book. For example, it is modestly interesting that Franklin Roosevelt, consistent with advice from Harry Hopkins and Admiral Ernest King, focused America’s productive effort on air and sea power. It is not at all central to the argument that air and sea power won the war. The fact that these particular people thought it was a good idea to build planes and ships matters less than the outcome that the U.S. did exactly that. I am very much interested in World War II history, and on an interestingness scale of 1-10, I found this discussion to be at about a 4. The central argument of the book about German and Japanese production was a consistent 10. Sidenote: MacArthur Was a Disastrous General In the part of the book focused on personnel, the one discussion that hit around a 9 or 10 was of Douglas MacArthur and the invasion of the Philippines. MacArthur was the American general commanding the defense of the Philippines. The Japanese conquered the Philippines, and MacArthur slipped away to Australia, heroically vowing, “I shall return.” He did in December 1944, and some of the worst fighting of the war took place, with massive casualties for the Americans, Japanese, and Filipino civilians. Fighting was still ongoing in the Philippines when the war ended in August 1945. The Americans took more than 220,000 casualties, the Japanese 430,000. Estimates vary on Filipino civilian deaths, but 750,000 is a credible middle of the road estimate. O’Brien’s contribution here was pointing out the strategic pointlessness of MacArthur’s invasion. The big American strategy in the western Pacific was to penetrate the Japanese defensive line of islands to link up with China. The northern Marianas Islands also were within heavy bomber range of Japan, and so would allow for efficient, effective bombing. (Bombing Japan from bases in China were logistically impractical, with virtually all materials being flown in over the Himalayas—another fascinating logistics discussion in this book.) The Americans had already conquered the Marianas Islands and had total air and sea dominance in the western Pacific. The forces the Japanese had in the Philippines could have been simply left to wither, as they had been on other islands bypassed by the island-hopping campaign. So, why did the Philippines invasion happen? The inescapable conclusion is that MacArthur was too politically formidable to risk angering, and he personally wanted to invade the Philippines to make good on his promise to return. Not coincidentally, the Philippines also offered some prospect of an extended land campaign where MacArthur could improve his reputation after his disastrous original defense of the Philippines. Also relevant, in O’Brien’s words: “MacArthur [] dazzled Roosevelt with tales of easy victories and grateful Filipinos and American voters.” Criticisms of HtWWW’s Central Argument I think it is clear from the data that O’Brien’s argument, that air and sea power played a more important role than land battles in deciding the war, is fundamentally right. Still, one can raise a few objections. Individual naval battles were capable of destroying a significant percentage of overall production. O’Brien discusses the Battle of Midway, where the Japanese lost four aircraft carriers (37 percent of their navy’s aircraft carriers at the time, 22 percent of all carriers they had during the war). This point doesn’t really disprove O’Brien’s core argument—it is basically a footnote saying that individual naval battles are more likely to matter than individual land battles. Politics and psychology matter tremendously in war, sometimes more than productive effort. O’Brien tacitly acknowledges this in the V-2 weapons discussion when he notes that the Germans spent all this money and effort on a psychological salve to the trauma of Allied bombing. The Japanese did ultimately surrender after the atomic bombings. (Or, if you are more on the revisionist end of the spectrum, they surrendered after the Soviets declared war.) France surrendered after a few disastrous battles. The productive effort lens might be useful, but subject to important caveats. Why Does the Conventional Narrative Focus on Battles? A perfect companion book to HtWWW would examine why military historians and the broader public have focused inordinately on battles. Here are some plausible factors: Battles are more dramatic. Propaganda during the war focused on battles so that there would be more inherent drama. Working twelve hour shifts in a factory to win the great battle is probably psychologically easier than thinking your work is going to disappear into an inchoate slog.

Inline links: https://substackcdn.com/image/fetch/$s_!DyEt!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F24c9f552-4f2a-4188-9b29-64191d48f307_835x496.png

Data from HtWWW, recreated to improve image quality. German oil shortages caused exactly the same training problem Japan had faced, with a slightly different but similarly disastrous outcome. Japanese training and production problems led to planes not arriving where they were supposed to in fighting condition (perhaps as few as 10% were actually combat capable when they arrived!) For Germany, training shortfalls meant annihilation for their air force as inexperienced pilots were forced to fight numerically and qualitatively superior American and British pilots. German monthly aircraft lost/damaged rates increased from 52.5% in January 1944 to 96.3% in June. One particularly illuminating episode illustrates how these problems manifested for Germany. The German air force had a reserve of 800 aircraft to counter the D-Day landings. The pilots of that force were used to only flying under expert control systems in Germany (countering bombing raids). When they went to France, they had trouble navigating and often landed on the wrong fields. Ultimately, they were poorly prepared to fight. The head of German fighter command was certain that the entire reserve did not destroy even two dozen Allied aircraft. American/British Airpower Decided the Outcome of Land Battles Beyond the strategic effects of bombing, tactical airpower (i.e., airplanes attacking land forces) gave an insurmountable advantage to the western Allies’ land forces. After D-Day, the Germans had a very strong defensive position in the hedgerows of northwest France. Allied aircraft literally carpet bombed one of the strongest divisions in the German army out of existence, with 70% casualties in one day. That division would normally have approximately 200 AFVs. At the end of that one day of bombing, it had 14. The Battle of the Bulge, the last offensive by the Germans to drive back the western Allies’ advance, was almost pathetic in its hopelessness. We Americans tend to focus on the hard fighting at the outset of the battle, and the stout resistance of the 101st Airborne at Bastogne. Knowing that airpower would make their attack impossible, the Germans timed the battle for bad weather and prayed it lasted as long as possible. Prayer was really the only option. Once the skies inevitably cleared after a little over a week of bad weather, more than 2,000(!) Allied bombers destroyed the German offensive. With most logistical support wiped out, one famous German division had to abandon all its vehicles and walk back to Germany. Criticism of HtWWW as a Book: Love the Data, (Mostly) Don’t Care About the People My single biggest criticism of HtWWW is O’Brien spends a lot of time (I would estimate 20% of the book) discussing the relative importance and influence of various people in the United States and United Kingdom. The section on Doug MacArthur is worth a longer digression, which I have included below. The problem is that focusing on personnel is almost completely irrelevant to the main argument of the book. For example, it is modestly interesting that Franklin Roosevelt, consistent with advice from Harry Hopkins and Admiral Ernest King, focused America’s productive effort on air and sea power. It is not at all central to the argument that air and sea power won the war. The fact that these particular people thought it was a good idea to build planes and ships matters less than the outcome that the U.S. did exactly that. I am very much interested in World War II history, and on an interestingness scale of 1-10, I found this discussion to be at about a 4. The central argument of the book about German and Japanese production was a consistent 10. Sidenote: MacArthur Was a Disastrous General In the part of the book focused on personnel, the one discussion that hit around a 9 or 10 was of Douglas MacArthur and the invasion of the Philippines. MacArthur was the American general commanding the defense of the Philippines. The Japanese conquered the Philippines, and MacArthur slipped away to Australia, heroically vowing, “I shall return.” He did in December 1944, and some of the worst fighting of the war took place, with massive casualties for the Americans, Japanese, and Filipino civilians. Fighting was still ongoing in the Philippines when the war ended in August 1945. The Americans took more than 220,000 casualties, the Japanese 430,000. Estimates vary on Filipino civilian deaths, but 750,000 is a credible middle of the road estimate. O’Brien’s contribution here was pointing out the strategic pointlessness of MacArthur’s invasion. The big American strategy in the western Pacific was to penetrate the Japanese defensive line of islands to link up with China. The northern Marianas Islands also were within heavy bomber range of Japan, and so would allow for efficient, effective bombing. (Bombing Japan from bases in China were logistically impractical, with virtually all materials being flown in over the Himalayas—another fascinating logistics discussion in this book.) The Americans had already conquered the Marianas Islands and had total air and sea dominance in the western Pacific. The forces the Japanese had in the Philippines could have been simply left to wither, as they had been on other islands bypassed by the island-hopping campaign. So, why did the Philippines invasion happen? The inescapable conclusion is that MacArthur was too politically formidable to risk angering, and he personally wanted to invade the Philippines to make good on his promise to return. Not coincidentally, the Philippines also offered some prospect of an extended land campaign where MacArthur could improve his reputation after his disastrous original defense of the Philippines. Also relevant, in O’Brien’s words: “MacArthur [] dazzled Roosevelt with tales of easy victories and grateful Filipinos and American voters.” Criticisms of HtWWW’s Central Argument I think it is clear from the data that O’Brien’s argument, that air and sea power played a more important role than land battles in deciding the war, is fundamentally right. Still, one can raise a few objections. Individual naval battles were capable of destroying a significant percentage of overall production. O’Brien discusses the Battle of Midway, where the Japanese lost four aircraft carriers (37 percent of their navy’s aircraft carriers at the time, 22 percent of all carriers they had during the war). This point doesn’t really disprove O’Brien’s core argument—it is basically a footnote saying that individual naval battles are more likely to matter than individual land battles. Politics and psychology matter tremendously in war, sometimes more than productive effort. O’Brien tacitly acknowledges this in the V-2 weapons discussion when he notes that the Germans spent all this money and effort on a psychological salve to the trauma of Allied bombing. The Japanese did ultimately surrender after the atomic bombings. (Or, if you are more on the revisionist end of the spectrum, they surrendered after the Soviets declared war.) France surrendered after a few disastrous battles. The productive effort lens might be useful, but subject to important caveats. Why Does the Conventional Narrative Focus on Battles? A perfect companion book to HtWWW would examine why military historians and the broader public have focused inordinately on battles. Here are some plausible factors: Battles are more dramatic. Propaganda during the war focused on battles so that there would be more inherent drama. Working twelve hour shifts in a factory to win the great battle is probably psychologically easier than thinking your work is going to disappear into an inchoate slog.

Links For December 2025

December 10, 2025 · Original source

24: Related: how the American public’s opinions on AI are changing (from David Shor, h/t Daniel Eth on X): If this is to be taken seriously, AI is already a bigger political issue than abortion, climate change, or the environment. I fail my 2023 prediction that there was only a 20% chance this would happen by 2028. 25: Related: Bernie Sanders in The Guardian: “There is a very real fear that, in the not-so-distant future, a super-intelligent AI could replace humans in controlling the planet.” The Left has a complicated relationship with existential risk from AI: they really hate AI, which in theory should push them towards yet another reason to be against it. But they hate AI so much that they need to believe every negative thing about it at the same time, and one of those negative things is that it’s just a scam and will never work, and this naturally pushes against being concerned about x-risk. But as AI improves, will the “just a scam” position become less tenable, shunting the associated psychic energy into other reasons to hate AI (including x-risk concerns)? 26: Qualia Research Institute has released a video describing some of the work they’ve been doing the past year - The Oscilleditor: An Algorithmic Breakthrough for Psychedelic Visual Replication (1080p•⚠️SEIZURE): 27: Jesse Arm (X): “A majority of American rabbinical students are now women. Most are also LGBTQ. That includes Modern Orthodoxy. Remove Modern Orthodoxy and the numbers climb even higher.” Clergy have always served as spiritual counselors; as religions liberalize and other roles become less important, the therapist role starts to predominate. But 75% of therapists in the US are female; at the limit of liberalization where clergyman = therapist, we should expect the same gender ratio. 28: The latest news on the COVID origins debate: scientists find a naturally-occuring bat coronavirus with a COVID-like furin cleavage site. This is a point in favor of the natural origins hypothesis, since the second-best argument for lab leak was that COVID’s furin cleavage site was too strange to evolve naturally. But I think arguments that lab leak has “fallen apart” are premature: the best argument (COVID emerged only a few miles from the biggest coronavirus gain-of-function lab in the Eastern Hemisphere) remains strong. I update from something like 95% chance it’s natural to something like 96%, but not 99.99% or anything. And here’s a lab leaker arguing that COVID’s furin cleavage site is out-of-frame and so still more unnatural-looking than the one on the recently-discovered bat virus. 29: Nicholas Decker (econ blogger, famous for his controversial autistic takes and Secret Service visit) has a dating doc. Most interesting section is the one about children: he wants to have them, but doesn’t think they should be genetically related to him. From here: If this appeals to you, you can find his contact info on the document. Related: Governor Jared Polis of Colorado is a fan of Nicholas Decker and Richard Hanania. 30: Matt Yglesias comes out as aphantasic (unable to see images in his “mind’s eye”). He says that contra the usual perspective that frames this as a deficit, he finds it helpful. For example, once he got assaulted, and he remembers on an intellectual level that it happened, but since “I wasn’t taking pictures of myself getting kicked in the head so, as far as I’m concerned, it’s like it happened to someone else” (Matt usually has good instincts, so I’m surprised he uses an example which will be such catnip to his conservative critics). He thinks it makes him a better reasoner / statistics blogger / effective altruist to be able to “get a statistically valid view of the situation, not overindex on the happenstance of your life.” For what it’s worth, I’ll give my contrary data point - I think of myself as a reasoner / statistics blogger / effective altruist in a pretty similar vein as Matt, but AFAICT my visual imagination is totally normal; if other people are having their emotions yanked around by vivid images, that’s a skill issue. 31: Lakshya Jain in The Argument: The COVID political backlash [to the Democratic Party] has disappeared. Despite the narrative, polls show that voters don’t favor or disfavor either party over COVID, mostly still think school closures were necessary, and are about evenly split on vaccine mandates. I guess I can’t disagree with this poll - it seems well-done - but I still wonder whether something is being missed. Maybe it didn’t make the ~50% of voters who are naturally liberal desert the cause, but it energized conservatives in a way that might otherwise not have happened? Related, from Rob Wiblin on X, on balance Britons think the government response to COVID was not strict enough. 32: Related: Back when neoreaction was a big deal, I occasionally discussed posts by neoreactionary blogger Spandrell of Bloody Shovel. If you’re wondering what happened to him, you can read his 2024 Post-Mortem Of Neoreaction here, where he discusses how he fell out of love with the movement (warning: he has not fallen out of love with racial slurs). As a former fascist sympathizer, I can see why [fascism is on the downswing]. The allure of fascism in 2024 is much, much diminished. For a few reasons. A big one was COVID. See, the point of fascism is that Collective Action is necessary to have nice things. We need a strong government committed to the good of the people. Yarvin showed his preference early when he started his new Substack by quoting Cicero’s phrase “Salus populi suprema lex”. The health of the people is the most important law. Cicero wasn’t a fascist of course, nor is Yarvin really; a big point of fascism is to narrowly define the populus as an ethnic group with demonstrable ties to blood. That makes the government’s ties to the people stronger, increasing their commitment to do Good Collective Action. Which is important. Very important. A lot of good things can come of intelligently done Collective Action. Fascist Italy made the trains run on time. Nazi Germany fixed the terrible Weimar economy. East Asian countries are all effectively fascist states, if with less ideological baggage (yellows just aren’t like that), and they are all nice, clean, safe places with healthy economies. Fascism is not a panacea but it works, when you let it. Strong government can be pretty neat. So why is strong government less appealing these days? Well, COVID happened. And our governments were pretty damn strong in dealing with it. They made strong laws and enforced them. And what did they do with their power? Absolutely retarded shit. They destroyed the world economy and made 95% of people completely miserable for 18 months. Up to 3 long years in some places. Again, as an Orient enjoyer I was very sympathetic of strong effective government. My life has been pretty cozy thanks to it for the past decades. But after seeing boomers, hypochondriacs, and menopausal women take the reins and use it against healthy people, I’m fucking done with strong effective government. Fuck that shit, I’m out. I don’t want to see strong effective government ever again. I was very lucky that I was out of China in November 2019. It was a fluke really. I moved to the Golden Triangle after that and the law of the jungle was much, much nicer during the Doctors Plague of 2020-2022. But I spent a few months in Europe during the time and man, that was brutal. Not just seeing how retarded governments were; the level of compliance by the people was so disheartening. Imagine being a sincere fascist and seeing your people behave like that. These are my people? My Volk? Am I supposed to sacrifice life and limb for the salus of this populus? Fuck that. Let them cook, they deserve everything that’s coming to them [...] Is there a way to make the body healthy again? I do think so. I think there’s still place for a successor right wing ideology which is neither Christian fundamentalism or robot worship. And it will happen; but it won’t happen on Twitter. Maybe it can happen on Urbit, or right here in this site. I have some ideas myself, and I invite you to join me and build this together. It would be funny if the solution to the paradox Jain highlights was that for every time a COVID lockdown turned a liberal into a conservative, it turned one fascist into a moderate, for a net rightward shift of zero. 33: Also from an Argument poll: In a hypothetical Presidential matchup, Gavin Newsom beats JD Vance 54-46. I’m split between the usual heuristic of ignoring any polling more than a year before an election, and the fact that this is a remarkably big lead for polarized 21st century America. 34: Jerl wades into the David Hume on miracles debate. 35: AI Teddy Bears: A Brief Investigation. The good news is that your child’s AI teddy bear is hard to jailbreak and probably will not tell them where to find guns: The other good news is that somehow they don’t charge a subscription, which makes them a way to get usually-subscription-only AI models for free. How is this possible? “[The most likely hypothesis is that] Witpaw is an adorable piece of spyware and he’s selling my data to the CCP”. 36: This month’s anti-people-named-Sacks content: NYT on Trump AI czar David Sacks’ conflicts of interest; New Yorker on whether neurologist Oliver Sacks used his case studies to work through his own issues rather than presenting them accurately. [EDITED TO ADD: I originally framed it this way as a joke, but on further research I think David and Oliver are related. Wikipedia says that Oliver was first cousins with Israel statesman Abba Eban, and that Abba Eban was born to Lithuanian Jewish parents in Cape Town. David Sacks’ bio says he was born to Jewish parents in Cape Town, and this article specifies that they were Lithuanian. I doubt there were too many Lithuanian Jewish families named Sacks in mid-1900s Cape Town, so sure, related!) 37: Orca Sciences: There Has To Be A Better Way To Make Titanium. Titanium is a great metal - strong, light, and tough. If we had cheap titanium, it could revolutionize manufacturing the way cheap steel and aluminum did in previous eras. So why don’t we? Not because titanium is rare: it’s “the 9th most common element in the earth’s crust”. Rather, it’s very complicated and expensive to extract from its ore. Some kind of breakthrough in titanium extraction processes always seems tantalizingly close, but has never quite materialized. Is there any hope? 38: If Asians Are Lactose Intolerant, Why All The Milk Tea? Lactose intolerance has confused me for a long time - 23andMe tells me that I’m lactose intolerant, but I drink milk regularly without problems, so what’s up? This post’s answer: lactose-intolerant people who don’t usually drink milk will get sick if they start suddenly. Lactose-intolerant people who drink milk regularly since childhood develop gut microbiota that can digest milk, but which demand an expensive “tax” in calories. Lactose-tolerant people will always be able to digest milk and absorb all the calories themselves. 39: How do different majors change college students’ political beliefs? No surprise that the humanities and social sciences shift people left; no surprise that business and economics shift them right. I was a little surprised that engineering shifts people right a little, and that Education of all things shifts people right (albeit only slightly). How is that even possible? Are these people coming in as Mao Zedong and leaving as “only” Leon Trotsky? Also, Political Science is exactly neutral, lol. [EDIT: I misunderstood, they’re using natural sciences as a zero point, this is a reasonable choice but slightly changes the interpretation] 40: Kindkristin: Language models improved my mental health. 41: More floor employment, from the WSJ (h/t @LaocoonofTroy): Big Paychecks Can’t Woo Enough Sailors For America’s Commercial Fleet: “Straight out of college, graduates from the country’s maritime academies can earn more than $200,000 as a commercial sailor, with free food and private accommodations... Despite the pay and perks, maritime jobs go begging, and it is raising national-security concerns.” Other selling points include “six months vacation, live wherever you want, and you’re serving the nation” and onboard “gyms, connectivity, and cuisine”. The catch is that you have to be at sea for months at a time. 42: Study (h/t @KierkegaardEmil): there was minimal “learning loss” from COVID school closures, best estimate is “0.02 standard deviations per 100 days of school closure”. I correctly predicted this back in 2021, but I also wrote in March of this year about how there’s been a general decline in NAEP scores since then. It seems like maybe a student having their specific school closed for longer than other schools didn’t hurt them, but some sort of general cultural change, maybe related to COVID, did hurt. 43: Sam Bankman-Fried’s mother on why she thinks his trial was unfair. SBF is appealing his conviction and will probably be making some of these same points in court. Can’t find a prediction market directly on the appeal, but this one says only 15% chance he serves under 10 years, this one says 15% chance of a Trump pardon, so it doesn’t seem like there’s much room for him to be freed (or get a significantly shorter sentence) on appeal. And Wired says that only 5-10% of appeals like these succeed. 44: Related: Trump pardons Juan Orlando Hernandez, former Honduran president extradited to the US for narco-corruption. Some sources are trying to find a Prospera angle - Prospera and other ZEDEs were approved under JOH’s administration, and the Prosperans seem to have good MAGAworld connections - but I don’t think this is their top priority, and I don’t know if it requires much explanation for Trump to be pro-right-wing Latin American politicians convicted by the Biden administration. More interesting is that apparently JOH and SBF were cellmates (X), “SBF spent extensive time helping JOH with trial prep” and SBF told an interviewer that “Juan Orlando is the most innocent prisoner I’ve met, myself included.” ChatGPT is not impressed with the Trump/SBF case for JOH’s innocence. Related: JOH’s conservative party on track to win this month’s extremely-close Honduran elections, great news for Prospera if it happens. 45: The “100 Above The Park” building in St Louis (h/t Bobby Fijan on X): 46: The death toll of the ongoing Sudan genocide has risen to about 150,000. Nicholas Kristof writes that the world has once again failed to prevent atrocities, and argues that the most important point of leverage is pressure on the United Arab Emirates, which is arming the genociders. Sam Kriss also writes about the situation in The World’s First Matcha Labubu Genocide, but is unimpressed with Kristof’s take: Sudan is passed over in a deeply uncomfortable silence. The absolute most you can do is blame the Emiratis. From what I’ve seen, more people seem to be appalled at the UAE for its frankly marginal role in arming the RSF than at the RSF itself. This is the approved way of understanding any inscrutably indigenous foreign conflict: you just worm out any third-party involvement and then act like you’ve solved the whole thing. I side with Kristof here, for reasons that Sam himself touches on later in his piece, in a section comparing Darfur with Gaza. It would be very easy to make people care about Darfur again. All it would take is a loud, vocal contingent of RSF apologists in the Western media. I agree, but would frame it less cynically: the reason Westerners pay attention to Gaza is that there’s a lever to push: not only does America support Israel, but many of their friends support Israel, so they can imagine convincing America or at least their friends to stop, and at least feel like there is some remote chance of making a small difference (and in fact, Trump getting mad at Israel and deciding to pressure them was decisive in effecting the cease-fire). On the other hand, we don’t have many levers to affect ethnic Baggara in the Rapid Support Forces of Sudan, so it doesn’t really feel useful to write blog posts arguing that they should stop; obviously they should stop, nobody disagrees with this, and it goes without saying - so nobody says it. But the US does support the UAE, and many of our friends like the UAE or at least go there on vacation, so maybe it’s possible to have make some small difference by embarrassing them. 4D chess take is that Sam Kriss agrees with all of this, but “loudly” and “vocally” argued against it to give people like me a hook to write about this genocide with, in which case I thank him for his sacrifice. It would also be nice to be able to donate, but I don’t know who to trust in the region - other than Doctors Without Borders, who are usually pretty good. 47: The AI Futures Project (group of AI-will-be-fast intellectuals) and the AI As A Normal Technology team (group of AI-will-be-slow intellectuals) wrote an adversarial collaboration in Asterisk explaining what they agree on, for example: That there’s an important distinction between existing AI and “strong AGI”

Inline links: Daniel Eth on X, https://substackcdn.com/image/fetch/$s_!kpou!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F9ada4ca1-d833-4fd1-b85a-5982191ce455_679x305.jpeg, my 2023 prediction, Bernie Sanders in, The Oscilleditor: An Algorithmic Breakthrough for Psychedelic Visual Replication (1080p•⚠️SEIZURE), Jesse Arm (X), scientists find a naturally-occuring bat coronavirus with a COVID-like furin cleavage site, has “fallen apart”, 95% chance, here’s a lab leaker arguing that, has a dating doc, From here, https://substackcdn.com/image/fetch/$s_!ByQP!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F90d5dfc6-106a-4afa-9250-371a21c77576_743x133.png, is a fan of, Matt Yglesias comes out as aphantasic, The COVID political backlash [to the Democratic Party] has disappeared., from Rob Wiblin on X, Post-Mortem Of Neoreaction, wades into the David Hume on miracles debate., AI Teddy Bears: A Brief Investigation, https://substackcdn.com/image/fetch/$s_!cOGB!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F20a7acea-b463-485c-8295-f0a5768381d9_416x709.png, Trump AI czar David Sacks’, neurologist Oliver Sacks, says, Abba Eban was, bio, this article, There Has To Be A Better Way To Make Titanium, If Asians Are Lactose Intolerant, Why All The Milk Tea?, How do different majors change college students’ political beliefs?, https://substackcdn.com/image/fetch/$s_!xR53!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fa36d404d-9574-4e25-93bb-7ef4d2ca9f9a_940x606.jpeg, as a zero point, Language models improved my mental health, floor employment, @LaocoonofTroy, Big Paychecks Can’t Woo Enough Sailors For America’s Commercial Fleet, Study, @KierkegaardEmil, correctly predicted this, wrote in March of this year, Sam Bankman-Fried’s mother on why she thinks his trial was unfair, appealing his conviction, this one, this one, Trump pardons Juan Orlando Hernandez, Some sources, JOH and SBF were cellmates (X), is not impressed, on track to win, Bobby Fijan on X, https://substackcdn.com/image/fetch/$s_!Gj0x!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fd354a169-6127-4815-85b5-940414c632eb_603x900.jpeg, Nicholas Kristof writes, The World’s First Matcha Labubu Genocide, and in fact, Trump getting mad at Israel and deciding to pressure them was decisive in effecting the cease-fire, Doctors Without Borders, an adversarial collaboration in Asterisk explaining what they agree on

If this is to be taken seriously, AI is already a bigger political issue than abortion, climate change, or the environment. I fail my 2023 prediction that there was only a 20% chance this would happen by 2028. 25: Related: Bernie Sanders in The Guardian: “There is a very real fear that, in the not-so-distant future, a super-intelligent AI could replace humans in controlling the planet.” The Left has a complicated relationship with existential risk from AI: they really hate AI, which in theory should push them towards yet another reason to be against it. But they hate AI so much that they need to believe every negative thing about it at the same time, and one of those negative things is that it’s just a scam and will never work, and this naturally pushes against being concerned about x-risk. But as AI improves, will the “just a scam” position become less tenable, shunting the associated psychic energy into other reasons to hate AI (including x-risk concerns)? 26: Qualia Research Institute has released a video describing some of the work they’ve been doing the past year - The Oscilleditor: An Algorithmic Breakthrough for Psychedelic Visual Replication (1080p•⚠️SEIZURE): 27: Jesse Arm (X): “A majority of American rabbinical students are now women. Most are also LGBTQ. That includes Modern Orthodoxy. Remove Modern Orthodoxy and the numbers climb even higher.” Clergy have always served as spiritual counselors; as religions liberalize and other roles become less important, the therapist role starts to predominate. But 75% of therapists in the US are female; at the limit of liberalization where clergyman = therapist, we should expect the same gender ratio. 28: The latest news on the COVID origins debate: scientists find a naturally-occuring bat coronavirus with a COVID-like furin cleavage site. This is a point in favor of the natural origins hypothesis, since the second-best argument for lab leak was that COVID’s furin cleavage site was too strange to evolve naturally. But I think arguments that lab leak has “fallen apart” are premature: the best argument (COVID emerged only a few miles from the biggest coronavirus gain-of-function lab in the Eastern Hemisphere) remains strong. I update from something like 95% chance it’s natural to something like 96%, but not 99.99% or anything. And here’s a lab leaker arguing that COVID’s furin cleavage site is out-of-frame and so still more unnatural-looking than the one on the recently-discovered bat virus. 29: Nicholas Decker (econ blogger, famous for his controversial autistic takes and Secret Service visit) has a dating doc. Most interesting section is the one about children: he wants to have them, but doesn’t think they should be genetically related to him. From here: If this appeals to you, you can find his contact info on the document. Related: Governor Jared Polis of Colorado is a fan of Nicholas Decker and Richard Hanania. 30: Matt Yglesias comes out as aphantasic (unable to see images in his “mind’s eye”). He says that contra the usual perspective that frames this as a deficit, he finds it helpful. For example, once he got assaulted, and he remembers on an intellectual level that it happened, but since “I wasn’t taking pictures of myself getting kicked in the head so, as far as I’m concerned, it’s like it happened to someone else” (Matt usually has good instincts, so I’m surprised he uses an example which will be such catnip to his conservative critics). He thinks it makes him a better reasoner / statistics blogger / effective altruist to be able to “get a statistically valid view of the situation, not overindex on the happenstance of your life.” For what it’s worth, I’ll give my contrary data point - I think of myself as a reasoner / statistics blogger / effective altruist in a pretty similar vein as Matt, but AFAICT my visual imagination is totally normal; if other people are having their emotions yanked around by vivid images, that’s a skill issue. 31: Lakshya Jain in The Argument: The COVID political backlash [to the Democratic Party] has disappeared. Despite the narrative, polls show that voters don’t favor or disfavor either party over COVID, mostly still think school closures were necessary, and are about evenly split on vaccine mandates. I guess I can’t disagree with this poll - it seems well-done - but I still wonder whether something is being missed. Maybe it didn’t make the ~50% of voters who are naturally liberal desert the cause, but it energized conservatives in a way that might otherwise not have happened? Related, from Rob Wiblin on X, on balance Britons think the government response to COVID was not strict enough. 32: Related: Back when neoreaction was a big deal, I occasionally discussed posts by neoreactionary blogger Spandrell of Bloody Shovel. If you’re wondering what happened to him, you can read his 2024 Post-Mortem Of Neoreaction here, where he discusses how he fell out of love with the movement (warning: he has not fallen out of love with racial slurs). As a former fascist sympathizer, I can see why [fascism is on the downswing]. The allure of fascism in 2024 is much, much diminished. For a few reasons. A big one was COVID. See, the point of fascism is that Collective Action is necessary to have nice things. We need a strong government committed to the good of the people. Yarvin showed his preference early when he started his new Substack by quoting Cicero’s phrase “Salus populi suprema lex”. The health of the people is the most important law. Cicero wasn’t a fascist of course, nor is Yarvin really; a big point of fascism is to narrowly define the populus as an ethnic group with demonstrable ties to blood. That makes the government’s ties to the people stronger, increasing their commitment to do Good Collective Action. Which is important. Very important. A lot of good things can come of intelligently done Collective Action. Fascist Italy made the trains run on time. Nazi Germany fixed the terrible Weimar economy. East Asian countries are all effectively fascist states, if with less ideological baggage (yellows just aren’t like that), and they are all nice, clean, safe places with healthy economies. Fascism is not a panacea but it works, when you let it. Strong government can be pretty neat. So why is strong government less appealing these days? Well, COVID happened. And our governments were pretty damn strong in dealing with it. They made strong laws and enforced them. And what did they do with their power? Absolutely retarded shit. They destroyed the world economy and made 95% of people completely miserable for 18 months. Up to 3 long years in some places. Again, as an Orient enjoyer I was very sympathetic of strong effective government. My life has been pretty cozy thanks to it for the past decades. But after seeing boomers, hypochondriacs, and menopausal women take the reins and use it against healthy people, I’m fucking done with strong effective government. Fuck that shit, I’m out. I don’t want to see strong effective government ever again. I was very lucky that I was out of China in November 2019. It was a fluke really. I moved to the Golden Triangle after that and the law of the jungle was much, much nicer during the Doctors Plague of 2020-2022. But I spent a few months in Europe during the time and man, that was brutal. Not just seeing how retarded governments were; the level of compliance by the people was so disheartening. Imagine being a sincere fascist and seeing your people behave like that. These are my people? My Volk? Am I supposed to sacrifice life and limb for the salus of this populus? Fuck that. Let them cook, they deserve everything that’s coming to them [...] Is there a way to make the body healthy again? I do think so. I think there’s still place for a successor right wing ideology which is neither Christian fundamentalism or robot worship. And it will happen; but it won’t happen on Twitter. Maybe it can happen on Urbit, or right here in this site. I have some ideas myself, and I invite you to join me and build this together. It would be funny if the solution to the paradox Jain highlights was that for every time a COVID lockdown turned a liberal into a conservative, it turned one fascist into a moderate, for a net rightward shift of zero. 33: Also from an Argument poll: In a hypothetical Presidential matchup, Gavin Newsom beats JD Vance 54-46. I’m split between the usual heuristic of ignoring any polling more than a year before an election, and the fact that this is a remarkably big lead for polarized 21st century America. 34: Jerl wades into the David Hume on miracles debate. 35: AI Teddy Bears: A Brief Investigation. The good news is that your child’s AI teddy bear is hard to jailbreak and probably will not tell them where to find guns: The other good news is that somehow they don’t charge a subscription, which makes them a way to get usually-subscription-only AI models for free. How is this possible? “[The most likely hypothesis is that] Witpaw is an adorable piece of spyware and he’s selling my data to the CCP”. 36: This month’s anti-people-named-Sacks content: NYT on Trump AI czar David Sacks’ conflicts of interest; New Yorker on whether neurologist Oliver Sacks used his case studies to work through his own issues rather than presenting them accurately. [EDITED TO ADD: I originally framed it this way as a joke, but on further research I think David and Oliver are related. Wikipedia says that Oliver was first cousins with Israel statesman Abba Eban, and that Abba Eban was born to Lithuanian Jewish parents in Cape Town. David Sacks’ bio says he was born to Jewish parents in Cape Town, and this article specifies that they were Lithuanian. I doubt there were too many Lithuanian Jewish families named Sacks in mid-1900s Cape Town, so sure, related!) 37: Orca Sciences: There Has To Be A Better Way To Make Titanium. Titanium is a great metal - strong, light, and tough. If we had cheap titanium, it could revolutionize manufacturing the way cheap steel and aluminum did in previous eras. So why don’t we? Not because titanium is rare: it’s “the 9th most common element in the earth’s crust”. Rather, it’s very complicated and expensive to extract from its ore. Some kind of breakthrough in titanium extraction processes always seems tantalizingly close, but has never quite materialized. Is there any hope? 38: If Asians Are Lactose Intolerant, Why All The Milk Tea? Lactose intolerance has confused me for a long time - 23andMe tells me that I’m lactose intolerant, but I drink milk regularly without problems, so what’s up? This post’s answer: lactose-intolerant people who don’t usually drink milk will get sick if they start suddenly. Lactose-intolerant people who drink milk regularly since childhood develop gut microbiota that can digest milk, but which demand an expensive “tax” in calories. Lactose-tolerant people will always be able to digest milk and absorb all the calories themselves. 39: How do different majors change college students’ political beliefs? No surprise that the humanities and social sciences shift people left; no surprise that business and economics shift them right. I was a little surprised that engineering shifts people right a little, and that Education of all things shifts people right (albeit only slightly). How is that even possible? Are these people coming in as Mao Zedong and leaving as “only” Leon Trotsky? Also, Political Science is exactly neutral, lol. [EDIT: I misunderstood, they’re using natural sciences as a zero point, this is a reasonable choice but slightly changes the interpretation] 40: Kindkristin: Language models improved my mental health. 41: More floor employment, from the WSJ (h/t @LaocoonofTroy): Big Paychecks Can’t Woo Enough Sailors For America’s Commercial Fleet: “Straight out of college, graduates from the country’s maritime academies can earn more than $200,000 as a commercial sailor, with free food and private accommodations... Despite the pay and perks, maritime jobs go begging, and it is raising national-security concerns.” Other selling points include “six months vacation, live wherever you want, and you’re serving the nation” and onboard “gyms, connectivity, and cuisine”. The catch is that you have to be at sea for months at a time. 42: Study (h/t @KierkegaardEmil): there was minimal “learning loss” from COVID school closures, best estimate is “0.02 standard deviations per 100 days of school closure”. I correctly predicted this back in 2021, but I also wrote in March of this year about how there’s been a general decline in NAEP scores since then. It seems like maybe a student having their specific school closed for longer than other schools didn’t hurt them, but some sort of general cultural change, maybe related to COVID, did hurt. 43: Sam Bankman-Fried’s mother on why she thinks his trial was unfair. SBF is appealing his conviction and will probably be making some of these same points in court. Can’t find a prediction market directly on the appeal, but this one says only 15% chance he serves under 10 years, this one says 15% chance of a Trump pardon, so it doesn’t seem like there’s much room for him to be freed (or get a significantly shorter sentence) on appeal. And Wired says that only 5-10% of appeals like these succeed. 44: Related: Trump pardons Juan Orlando Hernandez, former Honduran president extradited to the US for narco-corruption. Some sources are trying to find a Prospera angle - Prospera and other ZEDEs were approved under JOH’s administration, and the Prosperans seem to have good MAGAworld connections - but I don’t think this is their top priority, and I don’t know if it requires much explanation for Trump to be pro-right-wing Latin American politicians convicted by the Biden administration. More interesting is that apparently JOH and SBF were cellmates (X), “SBF spent extensive time helping JOH with trial prep” and SBF told an interviewer that “Juan Orlando is the most innocent prisoner I’ve met, myself included.” ChatGPT is not impressed with the Trump/SBF case for JOH’s innocence. Related: JOH’s conservative party on track to win this month’s extremely-close Honduran elections, great news for Prospera if it happens. 45: The “100 Above The Park” building in St Louis (h/t Bobby Fijan on X): 46: The death toll of the ongoing Sudan genocide has risen to about 150,000. Nicholas Kristof writes that the world has once again failed to prevent atrocities, and argues that the most important point of leverage is pressure on the United Arab Emirates, which is arming the genociders. Sam Kriss also writes about the situation in The World’s First Matcha Labubu Genocide, but is unimpressed with Kristof’s take: Sudan is passed over in a deeply uncomfortable silence. The absolute most you can do is blame the Emiratis. From what I’ve seen, more people seem to be appalled at the UAE for its frankly marginal role in arming the RSF than at the RSF itself. This is the approved way of understanding any inscrutably indigenous foreign conflict: you just worm out any third-party involvement and then act like you’ve solved the whole thing. I side with Kristof here, for reasons that Sam himself touches on later in his piece, in a section comparing Darfur with Gaza. It would be very easy to make people care about Darfur again. All it would take is a loud, vocal contingent of RSF apologists in the Western media. I agree, but would frame it less cynically: the reason Westerners pay attention to Gaza is that there’s a lever to push: not only does America support Israel, but many of their friends support Israel, so they can imagine convincing America or at least their friends to stop, and at least feel like there is some remote chance of making a small difference (and in fact, Trump getting mad at Israel and deciding to pressure them was decisive in effecting the cease-fire). On the other hand, we don’t have many levers to affect ethnic Baggara in the Rapid Support Forces of Sudan, so it doesn’t really feel useful to write blog posts arguing that they should stop; obviously they should stop, nobody disagrees with this, and it goes without saying - so nobody says it. But the US does support the UAE, and many of our friends like the UAE or at least go there on vacation, so maybe it’s possible to have make some small difference by embarrassing them. 4D chess take is that Sam Kriss agrees with all of this, but “loudly” and “vocally” argued against it to give people like me a hook to write about this genocide with, in which case I thank him for his sacrifice. It would also be nice to be able to donate, but I don’t know who to trust in the region - other than Doctors Without Borders, who are usually pretty good. 47: The AI Futures Project (group of AI-will-be-fast intellectuals) and the AI As A Normal Technology team (group of AI-will-be-slow intellectuals) wrote an adversarial collaboration in Asterisk explaining what they agree on, for example: That there’s an important distinction between existing AI and “strong AGI”

Inline links: my 2023 prediction, Bernie Sanders in, The Oscilleditor: An Algorithmic Breakthrough for Psychedelic Visual Replication (1080p•⚠️SEIZURE), Jesse Arm (X), scientists find a naturally-occuring bat coronavirus with a COVID-like furin cleavage site, has “fallen apart”, 95% chance, here’s a lab leaker arguing that, has a dating doc, From here, https://substackcdn.com/image/fetch/$s_!ByQP!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F90d5dfc6-106a-4afa-9250-371a21c77576_743x133.png, is a fan of, Matt Yglesias comes out as aphantasic, The COVID political backlash [to the Democratic Party] has disappeared., from Rob Wiblin on X, Post-Mortem Of Neoreaction, wades into the David Hume on miracles debate., AI Teddy Bears: A Brief Investigation, https://substackcdn.com/image/fetch/$s_!cOGB!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F20a7acea-b463-485c-8295-f0a5768381d9_416x709.png, Trump AI czar David Sacks’, neurologist Oliver Sacks, says, Abba Eban was, bio, this article, There Has To Be A Better Way To Make Titanium, If Asians Are Lactose Intolerant, Why All The Milk Tea?, How do different majors change college students’ political beliefs?, https://substackcdn.com/image/fetch/$s_!xR53!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fa36d404d-9574-4e25-93bb-7ef4d2ca9f9a_940x606.jpeg, as a zero point, Language models improved my mental health, floor employment, @LaocoonofTroy, Big Paychecks Can’t Woo Enough Sailors For America’s Commercial Fleet, Study, @KierkegaardEmil, correctly predicted this, wrote in March of this year, Sam Bankman-Fried’s mother on why she thinks his trial was unfair, appealing his conviction, this one, this one, Trump pardons Juan Orlando Hernandez, Some sources, JOH and SBF were cellmates (X), is not impressed, on track to win, Bobby Fijan on X, https://substackcdn.com/image/fetch/$s_!Gj0x!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fd354a169-6127-4815-85b5-940414c632eb_603x900.jpeg, Nicholas Kristof writes, The World’s First Matcha Labubu Genocide, and in fact, Trump getting mad at Israel and deciding to pressure them was decisive in effecting the cease-fire, Doctors Without Borders, an adversarial collaboration in Asterisk explaining what they agree on

No surprise that the humanities and social sciences shift people left; no surprise that business and economics shift them right. I was a little surprised that engineering shifts people right a little, and that Education of all things shifts people right (albeit only slightly). How is that even possible? Are these people coming in as Mao Zedong and leaving as “only” Leon Trotsky? Also, Political Science is exactly neutral, lol. [EDIT: I misunderstood, they’re using natural sciences as a zero point, this is a reasonable choice but slightly changes the interpretation] 40: Kindkristin: Language models improved my mental health. 41: More floor employment, from the WSJ (h/t @LaocoonofTroy): Big Paychecks Can’t Woo Enough Sailors For America’s Commercial Fleet: “Straight out of college, graduates from the country’s maritime academies can earn more than $200,000 as a commercial sailor, with free food and private accommodations... Despite the pay and perks, maritime jobs go begging, and it is raising national-security concerns.” Other selling points include “six months vacation, live wherever you want, and you’re serving the nation” and onboard “gyms, connectivity, and cuisine”. The catch is that you have to be at sea for months at a time. 42: Study (h/t @KierkegaardEmil): there was minimal “learning loss” from COVID school closures, best estimate is “0.02 standard deviations per 100 days of school closure”. I correctly predicted this back in 2021, but I also wrote in March of this year about how there’s been a general decline in NAEP scores since then. It seems like maybe a student having their specific school closed for longer than other schools didn’t hurt them, but some sort of general cultural change, maybe related to COVID, did hurt. 43: Sam Bankman-Fried’s mother on why she thinks his trial was unfair. SBF is appealing his conviction and will probably be making some of these same points in court. Can’t find a prediction market directly on the appeal, but this one says only 15% chance he serves under 10 years, this one says 15% chance of a Trump pardon, so it doesn’t seem like there’s much room for him to be freed (or get a significantly shorter sentence) on appeal. And Wired says that only 5-10% of appeals like these succeed. 44: Related: Trump pardons Juan Orlando Hernandez, former Honduran president extradited to the US for narco-corruption. Some sources are trying to find a Prospera angle - Prospera and other ZEDEs were approved under JOH’s administration, and the Prosperans seem to have good MAGAworld connections - but I don’t think this is their top priority, and I don’t know if it requires much explanation for Trump to be pro-right-wing Latin American politicians convicted by the Biden administration. More interesting is that apparently JOH and SBF were cellmates (X), “SBF spent extensive time helping JOH with trial prep” and SBF told an interviewer that “Juan Orlando is the most innocent prisoner I’ve met, myself included.” ChatGPT is not impressed with the Trump/SBF case for JOH’s innocence. Related: JOH’s conservative party on track to win this month’s extremely-close Honduran elections, great news for Prospera if it happens. 45: The “100 Above The Park” building in St Louis (h/t Bobby Fijan on X): 46: The death toll of the ongoing Sudan genocide has risen to about 150,000. Nicholas Kristof writes that the world has once again failed to prevent atrocities, and argues that the most important point of leverage is pressure on the United Arab Emirates, which is arming the genociders. Sam Kriss also writes about the situation in The World’s First Matcha Labubu Genocide, but is unimpressed with Kristof’s take: Sudan is passed over in a deeply uncomfortable silence. The absolute most you can do is blame the Emiratis. From what I’ve seen, more people seem to be appalled at the UAE for its frankly marginal role in arming the RSF than at the RSF itself. This is the approved way of understanding any inscrutably indigenous foreign conflict: you just worm out any third-party involvement and then act like you’ve solved the whole thing. I side with Kristof here, for reasons that Sam himself touches on later in his piece, in a section comparing Darfur with Gaza. It would be very easy to make people care about Darfur again. All it would take is a loud, vocal contingent of RSF apologists in the Western media. I agree, but would frame it less cynically: the reason Westerners pay attention to Gaza is that there’s a lever to push: not only does America support Israel, but many of their friends support Israel, so they can imagine convincing America or at least their friends to stop, and at least feel like there is some remote chance of making a small difference (and in fact, Trump getting mad at Israel and deciding to pressure them was decisive in effecting the cease-fire). On the other hand, we don’t have many levers to affect ethnic Baggara in the Rapid Support Forces of Sudan, so it doesn’t really feel useful to write blog posts arguing that they should stop; obviously they should stop, nobody disagrees with this, and it goes without saying - so nobody says it. But the US does support the UAE, and many of our friends like the UAE or at least go there on vacation, so maybe it’s possible to have make some small difference by embarrassing them. 4D chess take is that Sam Kriss agrees with all of this, but “loudly” and “vocally” argued against it to give people like me a hook to write about this genocide with, in which case I thank him for his sacrifice. It would also be nice to be able to donate, but I don’t know who to trust in the region - other than Doctors Without Borders, who are usually pretty good. 47: The AI Futures Project (group of AI-will-be-fast intellectuals) and the AI As A Normal Technology team (group of AI-will-be-slow intellectuals) wrote an adversarial collaboration in Asterisk explaining what they agree on, for example: That there’s an important distinction between existing AI and “strong AGI”

Inline links: as a zero point, Language models improved my mental health, floor employment, @LaocoonofTroy, Big Paychecks Can’t Woo Enough Sailors For America’s Commercial Fleet, Study, @KierkegaardEmil, correctly predicted this, wrote in March of this year, Sam Bankman-Fried’s mother on why she thinks his trial was unfair, appealing his conviction, this one, this one, Trump pardons Juan Orlando Hernandez, Some sources, JOH and SBF were cellmates (X), is not impressed, on track to win, Bobby Fijan on X, https://substackcdn.com/image/fetch/$s_!Gj0x!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fd354a169-6127-4815-85b5-940414c632eb_603x900.jpeg, Nicholas Kristof writes, The World’s First Matcha Labubu Genocide, and in fact, Trump getting mad at Israel and deciding to pressure them was decisive in effecting the cease-fire, Doctors Without Borders, an adversarial collaboration in Asterisk explaining what they agree on

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